Visual Attention in Crisis
Behav Brain Sci. 2024 May 3:1-32. doi: 10.1017/S0140525X24000323. Online ahead of print.ABSTRACTResearch on visual attention has uncovered significant anomalies, and some traditional methods may have inadvertently probed peripheral vision rather than attention. Vision science needs to rethink visual attention from the ground up. To facilitate this, for a year I banned the word "attention" in my lab. This constraint promoted a more precise discussion of attention-related phenomena, capacity limits, and mechanisms. The insights gained lead me to challenge attributing to "attention" those phenomena that can be better explaine...
Source: The Behavioral and Brain Sciences - May 3, 2024 Category: Neuroscience Authors: Ruth Rosenholtz Source Type: research
Oxytocin and corticotropin-releasing hormone exaggerate nucleus tractus solitarii neuronal and synaptic activity following chronic intermittent hypoxia
In this study, we focused on OT and CRH individually and together on nTS activity from rats exposed to either CIH or normoxia control. We show that after CIH, CRH alone and with OT increased to a greater extent overall nTS discharge, neuronal calcium influx, synaptic transmission to second-order nTS neurons, and OT and CRH receptor expression. These results provide insights into the underlying circuits and mechanisms contributing to autonomic dysfunction during periods of episodic breathing.PMID:38698722 | DOI:10.1113/JP286069 (Source: The Journal of Physiology)
Source: The Journal of Physiology - May 3, 2024 Category: Physiology Authors: Procopio Gama de Barcellos Filho Heather A Dantzler Eileen M Hasser David D Kline Source Type: research
Identification of Key Genes and Pathways in Oxaliplatin-Induced Neuropathic Pain Through Bioinformatic Analysis
(Source: Journal of Pain Research)
Source: Journal of Pain Research - May 3, 2024 Category: Anesthesiology Tags: Journal of Pain Research Source Type: research
Detecting language network alterations in mild cognitive impairment using task ‐based fMRI and resting‐state fMRI: A comparative study
ConclusionTask-based fMRI and ICA are more sophisticated and reliable tools in evaluation cognitive impairments in language processing. Our findings support the neural mechanisms of the cognitive impairments in MCI. (Source: Brain and Behavior)
Source: Brain and Behavior - May 3, 2024 Category: Neurology Authors: Kerem Kemik,
Emel Ada,
Berrin Çavuşoğlu,
Cansu Aykaç,
Derya Durusu Emek Savaş,
Görsev Yener Tags: ORIGINAL ARTICLE Source Type: research
Galectin ‐3 levels and long‐term all‐cause mortality and hospitalization in heart failure patients: a meta‐analysis
ConclusionsHigher circulating galectin-3 levels after hospitalization of HF patients are linearly and positively associated with the risk of long-term ACM and ACM/HFR. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 3, 2024 Category: Cardiology Authors: Wenke Cheng,
Rosolowski Maciej,
Holger Thiele,
Petra B üttner Tags: Original Article Source Type: research
Subthalamic nucleus synchronization between beta band local field potential and single ‐unit activity in Parkinson's disease
AbstractLocal field potential (LFP) oscillations in the beta band (13 –30 Hz) in the subthalamic nucleus (STN) of Parkinson's disease patients have been implicated in disease severity and treatment response. The relationship between single-neuron activity in the STN and regional beta power changes remains unclear. We used spike-triggered average (STA) to assess be ta synchronization in STN. Beta power and STA magnitude at the beta frequency range were compared in three conditions: STN versus other subcortical structures, dorsal versus ventral STN, and high versus low beta power STN recordings. Magnitude of STA-LFP was ...
Source: Physiological Reports - May 3, 2024 Category: Physiology Authors: Eric Bayman,
Keanu Chee,
Madelyn Mendlen,
Daniel J. Denman,
Rex N. Tien,
Steven Ojemann,
Daniel R. Kramer,
John A. Thompson Tags: ORIGINAL ARTICLE Source Type: research
Investigating disparities in smoking cessation treatment for veterans with multiple sclerosis: A national analysis
ConclusionVwMS received significantly less smoking cessation treatment, compared to matched controls without MS, showing a critical gap in health services as VwMS are not receiving dual NRT as the standard of care. Prescription rates were especially lower for male and Black VwMS, suggesting that under-represented demographic groups outside of the white female category, most often considered as the “traditional MS” group, could be under-treated regarding smoking cessation support. This foundational work will help inform future work to promote equitable treatment and implementation of cessation interventions for people l...
Source: Brain and Behavior - May 3, 2024 Category: Neurology Authors: Carri S. Polick,
Paul Dennis,
Patrick S. Calhoun,
Tiffany J. Braley,
Eunice Lee,
Sarah Wilson Tags: ORIGINAL ARTICLE Source Type: research
Electroacupuncture modulates abnormal brain connectivity after ischemia reperfusion injury in rats: A graph theory ‐based approach
ConclusionThe results of this study provide a potential basis for EA to promote cognitive and motor function recovery after ischemic stroke. (Source: Brain and Behavior)
Source: Brain and Behavior - May 3, 2024 Category: Neurology Authors: Si ‐Si Li,
Xiang‐Xin Xing,
Xu‐Yun Hua,
Yu‐Wen Zhang,
Jia‐Jia Wu,
Chun‐Lei Shan,
He Wang,
Mou‐Xiong Zheng,
Jian‐Guang Xu Tags: ORIGINAL ARTICLE Source Type: research
Implications of anti ‐ganglioside antibodies in isolated dysphagia following COVID‐19 infection: Case series
We report particular cases of three patients with unexplained dysphagia after coronavirus disease 2019 (COVID-19) diagnosis, who all showed linkage to anti-ganglioside antibodies against the NeuNAc( Î ± 2-3)Gal as possible causes. AbstractBackgroundThere have been multiple reports about the occurrence of dysphagia after the contraction of coronavirus disease 2019 (COVID-19). However, a detailed pathology and epidemiologic relation between COVID-19 infection and dysphagia have yet to be established. Here, we report three cases of unexplained dysphagia after COVID-19 diagnosis, with atypical clinical presentations.Case r...
Source: Brain and Behavior - May 3, 2024 Category: Neurology Authors: Sejoon Kim,
Jisun Bae,
Geun ‐Young Park,
Sun Im Tags: BRIEF REPORT Source Type: research
Restricting Conformational Space: A New Blueprint for Electrically Switchable Self ‐Assembled Monolayers
The reorientation of molecular dipoles in a tunnel junction based on a self-assembled monolayer (SAM) is key to a new class of memory devices. Restricting the conformational flexibility of the polar moieties reduces scattering of the current –voltage response and results in highly reproducible switching. The devices are simple to fabricate and offer a new direction toward neuromorphic and in-memory computing. AbstractTunnel junctions comprising self-assembled monolayers (SAMs) from liquid crystal-inspired molecules show a pronounced hysteretic current –voltage response, due to electric field-driven dipole reorientation...
Source: Small - May 3, 2024 Category: Nanotechnology Authors: Peer Kirsch,
Julian M. Dlugosch,
Takuya Kamiyama,
Christian Pfeiffer,
Henning Seim,
Sebastian Resch,
Frank Voges,
Itai Lieberman,
Abin Nas Nalakath,
Yangbiao Liu,
Michael Zharnikov,
Marc Tornow Tags: Research Article Source Type: research
GSE231638 Single-Nuclei RNA Sequencing identifies transcriptomic signature changes in a chimeric transplantation model of Alzheimer ’s disease
This study explored the intrinsic changes of AD neurons that carry a familial AD mutation (APP London mutation) using iPSC-derived neurons in vitro and in vivo. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 3, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research
GSE231639 RNA Sequencing identifies transcriptomic signature changes in a chimeric transplantation model of Alzheimer ’s disease
This study explored the intrinsic changes of AD neurons that carry a familial AD mutation (APP London mutation) using iPSC-derived neurons in vitro and in vivo. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 3, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research
GSE241602 Dynamic Chromatin Alteration Induces Oncogenic Hijacking by Nuclear Factor I Family Proteins for Medulloblastoma Progression
Series Type : Expression profiling by high throughput sequencingOrganism :The cancer-specific epigenome is the critical scaffold on which genetic programs work to positively promote cancer growth and progression. Understanding and appropriately disrupting this epigenome will lead to the discovery of new, more extensive and effective therapies in addition to conventional personalized medicine that relies on genomic mutations. However, the epigenomic changes during the process from normal cells to cancer formation as well as the molecules involved in the maintenance of the aberrant epigenome are still poorly characterized, a...
Source: GEO: Gene Expression Omnibus - May 3, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research
GSE247439 miRNA-mediated inhibition of an actomyosin network in hippocampal pyramidal neurons restricts sociability in adult male mice
Contributors : Ramanathan Narayanan ; Pierre-Luc Germain ; Gerhard SchrattSeries Type : Expression profiling by high throughput sequencingOrganism :We recently reported that the loss of the microRNA cluster miR-379-410 leads to hypersocial behavior and anxiety in mice. With this study, we show that ablating miR-379-410 in excitatory neurons of the postnatal mouse hippocampus recapitulates hypersociability, but not anxiety. At the cellular level, miR-379-410 loss in excitatory neurons leads to increased excitatory synaptic transmission and upregulation of an actomyosin gene network. Re-expression of three cluster miRNAs,...
Source: GEO: Gene Expression Omnibus - May 3, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research
GSE255987 Brain-wide AAV-mediated silencing of prion protein by a compact epigenetic editor
Contributors : Tessa Bertozzi ; Edwin Neumann ; Jonathan WeissmanSeries Type : Expression profiling by high throughput sequencingOrganism :Prion disease is caused by misfolding of the prion protein (PrP) into pathogenic self-propagating conformations, leading to rapid onset dementia and death. However, elimination of endogenous PrP can halt prion disease progression. Here, we describe CHARM, a compact, enzyme-free epigenetic editor capable of silencing transcription through programmable targeted DNA methylation. Using a histone H3 tail-Dnmt3l fusion, CHARM recruits and activates the endogenous DNA methyltransferases, th...
Source: GEO: Gene Expression Omnibus - May 3, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research
