Pancytopenia as a first presentation of late-onset systemic lupus erythematosus: a case report
CONCLUSION: It is important to assess any unusual presentation of SLEs when clinical suspicion remains high and conducting further laboratory and imaging investigation.PMID:38694390 | PMC:PMC11060222 | DOI:10.1097/MS9.0000000000001891 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Ghina Haidar Naram Khalayli Tasneem Drie Mhd Homam Safiah Maysoun Kudsi Source Type: research
Fibrocartilaginous embolism: a rare cause of cervical spine infarction
CONCLUSION: When a practitioner suspects that a patient may have fibrocartilaginous embolism (FCE), they should take the patient's history and do a neurological examination. An MRI is required since it is thought to be the most accurate method of diagnosing FCE.PMID:38694385 | PMC:PMC11060198 | DOI:10.1097/MS9.0000000000002005 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Widad Abu Mayyala Nawras Abu Aqeel Afnan W M Jobran Farah Shaheen Mohammed Abdulrazzak Yousef Alhroub Source Type: research
Unilateral lateral rectus palsy following dengue: a case report
CONCLUSION: This is the first documented case report of paralytic squint post-severe dengue in Nepal, emphasizing the importance of considering it as a differential diagnosis in tropical regions with endemic dengue infections. The case report advocates early identification and treatment of ophthalmic issues, notably with prednisolone, to achieve favourable outcomes, as evidenced by improvements in visual acuity, esotropia, and diplopia during follow-ups. Further research is essential to determine optimal treatment strategies for such neurological complications associated with dengue fever.PMID:38694359 | PMC:PMC11060301 | ...
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Biraj Niraula Bindira Adhikari Anil Suvedi Dinesh Gosain Shivendra Kumar Gaud Source Type: research
Bardet-Biedl syndrome with unique manifestations of congenital giant nevi and refractory anemia: a case report from Palestine
CONCLUSION: This case underscores BBS's rarity and complexity, featuring unique aspects like giant nevi and refractory IDA. Comprehensive management addresses renal, visual, cardiac, and neurologic aspects. Genetic counselling, prenatal testing, and preimplantation genetic diagnosis prevent transmission. Limitations include lacking local epidemiological data and prior studies in Palestine. This case contributes insights, stressing multidisciplinary management and prompting further research in underexplored populations.PMID:38694397 | PMC:PMC11060271 | DOI:10.1097/MS9.0000000000001954 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Mohammad Milhem Daleen Shehadeh Yasmeen Abu Nawa Roa Arman Lara Masri Zeena Salman Mohammad Najajreh Source Type: research
Incidental diagnosis of primary appendiceal signet-ring cell adenocarcinoma after appendectomy for acute appendicitis: a case report
CONCLUSION: Early diagnosis of ASCA can incidentally be made on pathological specimen following appendectomy for appendicitis. A routine pathological examination should be emphasized, and appendectomy may not be the endpoint of the treatment. Hemicolectomy and adjuvant therapy might ensue upon the diagnosis of appendiceal neoplasm. The poor prognosis of ASCA makes a timely diagnosis significant. Basic research is promising to unravel the molecular mechanisms of pathogenesis, finding typical tumor markers for screening and novel effective therapies for advanced cases.PMID:38694365 | PMC:PMC11060291 | DOI:10.1097/MS9.0000000...
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Miao Xie Fei Li Source Type: research
Iron chelators: as therapeutic agents in diseases
Ann Med Surg (Lond). 2024 Mar 19;86(5):2759-2776. doi: 10.1097/MS9.0000000000001717. eCollection 2024 May.ABSTRACTThe concentration of iron is tightly regulated, making it an essential element. Various cellular processes in the body rely on iron, such as oxygen sensing, oxygen transport, electron transfer, and DNA synthesis. Iron excess can be toxic because it participates in redox reactions that catalyze the production of reactive oxygen species and elevate oxidative stress. Iron chelators are chemically diverse; they can coordinate six ligands in an octagonal sequence. Because of the ability of chelators to trap essentia...
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Zohreh Salimi Mehdi Afsharinasab Mehdi Rostami Yaser Eshaghi Milasi Seyedeh Fatemeh Mousavi Ezmareh Fariba Sakhaei Maryam Mohammad-Sadeghipour Sayyed Mehdi Rasooli Manesh Zatollah Asemi Source Type: research
Absence of ATM leads to altered NK cell function in mice
Clin Immunol. 2024 Apr 30:110233. doi: 10.1016/j.clim.2024.110233. Online ahead of print.ABSTRACTAtaxia-telangiectasia (A-T) is a rare disorder caused by genetic defects of A-T mutated (ATM) kinase, a key regulator of stress response, and characterized by neurodegeneration, immunodeficiency, and high incidence of cancer. Here we investigated NK cells in a mouse model of A-T (Atm-/-) showing that they are strongly impaired at killing tumor cells due to a block of early signaling events. On the other hand, in Atm-/- littermates with thymic lymphoma NK cell cytotoxicity is enhanced as compared with ATM-proficient mice, possib...
Source: Clinical Immunology - May 2, 2024 Category: Allergy & Immunology Authors: Daniela Angela Covino Maria Giovanna Desimio Alessandro Giovinazzo Bruna Sabino Pinho de Oliveira Matilde Merolle Daniela Marazziti Manuela Pellegrini Margherita Doria Source Type: research
ST2 levels and neurodegenerative diseases: is this a significant relation?
Ann Med Surg (Lond). 2024 Mar 12;86(5):2812-2817. doi: 10.1097/MS9.0000000000001939. eCollection 2024 May.ABSTRACTInterleukin-33 (IL-33), belonging to the interleukin-1 cytokine family, has a decoy receptor soluble ST2 (sST2). IL-33 is found in oligodendrocytes and astrocytes and is involved in central nervous system healing and repair, whereas ST2 is found in microglia and astrocytes. Some studies have found a link between changes in the IL-33/ST2 pathway and neurodegenerative disorders. This review article investigates the relationship between the interleukin-33 (IL-33)/ST2 pathway and neurodegenerative disorders. It was...
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Himanshu Arora Binish Javed L V Simhachalam Kutikuppala Mayuri Chaurasia Kaarvi Khullar Shreevikaa Kannan Varshitha Golla Source Type: research
Fractionated stereotactic radiotherapy of intracranial postoperative cavities after resection of brain metastases - Clinical outcome and prognostic factors
CONCLUSION: FSRT after surgical resection of BM is an effective and safe treatment approach with excellent local control and acceptable toxicity. Further prospective randomized trials are needed to establish standardized therapeutic guidelines.PMID:38694237 | PMC:PMC11061678 | DOI:10.1016/j.ctro.2024.100782 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - May 2, 2024 Category: Cancer & Oncology Authors: L Hahnemann A Kr ämer C Fink C Jungk M Thomas P Christopoulos J W Lischalk J Meis J H örner-Rieber T Eichkorn M Deng K Lang A Paul E Meixner F Weykamp J Debus L K önig Source Type: research
Laser Interstitial Thermotherapy (LITT) in Recurrent Glioblastoma: What Window of Opportunity for This Treatment?
We describe the most recent updates regarding several studies and case reports that have evaluated the efficacy and safety of Laser Interstitial Thermotherapy for recurrent gliomas. These studies have reported different outcomes, with some demonstrating promising results in terms of tumor control and patient survival, while others have shown mixed outcomes. The success of Laser Interstitial Thermotherapy depends on various factors, including tumor characteristics, patient selection, and the experience of the surgical team, but the future direction of treatment of recurrent gliomas will include a combined approach, comprisi...
Source: Technology in Cancer Research and Treatment - May 2, 2024 Category: Cancer & Oncology Authors: Alberto Morello Andrea Bianconi Francesca Rizzo Jacopo Bellomo Anna Cristina Meyer Diego Garbossa Luca Regli Fabio Cofano Source Type: research
Moyamoya disease in a 2-year-old patient from the middle east: a case report and literature review
CONCLUSION: This case highlights the importance of identifying MMD in regions where it is uncommon to be diagnosed. It emphasizes the need for diagnosis and appropriate intervention to reduce complications.PMID:38694386 | PMC:PMC11060278 | DOI:10.1097/MS9.0000000000001934 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Haneen Mahmoud Nimer Habes Raneen B Alshareef Areen Amleh Ali A A Doudin Yousef Mahmoud Nimer Habes Mohammed Abdulrazzak Sharif Issa Basal Source Type: research
Antinociceptive effects of gamma-linolenic acid in the formalin test in the rats
CONCLUSION: The findings have validated the antinociceptive impact of GLA and hinted towards its immunomodulatory influence in the formalin test.PMID:38694379 | PMC:PMC11060212 | DOI:10.1097/MS9.0000000000002001 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Kaveh Rahimi Arman Nourishirazi Hamidreza Delaviz Zohreh Ghotbeddin Source Type: research
Junctional Neural Tube Defect : Two Case Report
J Korean Neurosurg Soc. 2024 May 2. doi: 10.3340/jkns.2024.0061. Online ahead of print.NO ABSTRACTPMID:38697665 | DOI:10.3340/jkns.2024.0061 (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - May 2, 2024 Category: Neurosurgery Authors: Bin Yuan Shungen Huang Xiangming Yan Hangzhou Wang Source Type: research
All available diagnostic and therapeutic options should be fully exploited in order to quickly identify and optimally treat neuropathic pain in long-COVID
Eur Arch Psychiatry Clin Neurosci. 2024 May 2. doi: 10.1007/s00406-024-01820-0. Online ahead of print.NO ABSTRACTPMID:38695877 | DOI:10.1007/s00406-024-01820-0 (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - May 2, 2024 Category: Psychiatry Authors: Josef Finsterer Source Type: research
Determination of dose for neuromuscular blocking drugs
Paediatr Anaesth. 2024 May 2. doi: 10.1111/pan.14916. Online ahead of print.NO ABSTRACTPMID:38693891 | DOI:10.1111/pan.14916 (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - May 2, 2024 Category: Anesthesiology Authors: L Ignacio Cortinez Brian J Anderson Source Type: research
