Re-awakening the brain: Forcing transitions in disorders of consciousness by external < i > in silico < /i > perturbation
by Paulina Clara Dagnino, Anira Escrichs, Ane L ópez-González, Olivia Gosseries, Jitka Annen, Yonatan Sanz Perl, Morten L. Kringelbach, Steven Laureys, Gustavo Deco
A fundamental challenge in neuroscience is accurately defining brain states and predicting how and where to perturb the brain to force a transition. Here, we investigated resting-state fMRI data of patients suffering from disorders of consciousness (DoC) after coma (minimally conscious and unresponsive wakefulness states) and healthy controls. We applied model-free and model-based approaches to help elucidate the underlying brain mechanisms of patients with ...
Source: PLoS Computational Biology - May 3, 2024 Category: Biology Authors: Paulina Clara Dagnino Source Type: research
Nuclear and degradative functions of the ESCRT-III pathway: implications for neurodegenerative disease
Volume 15, Issue 1, December 2024 . (Source: Nucleus)
Source: Nucleus - May 3, 2024 Category: Molecular Biology Authors: Olivia KeeleyAlyssa N. Coynea Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USAb Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA Source Type: research
Novel protein-truncating variants of a chromatin-modifying gene MSL2 in syndromic neurodevelopmental disorders
European Journal of Human Genetics, Published online: 03 May 2024; doi:10.1038/s41431-024-01576-0Novel protein-truncating variants of a chromatin-modifying gene MSL2 in syndromic neurodevelopmental disorders (Source: European Journal of Human Genetics)
Source: European Journal of Human Genetics - May 3, 2024 Category: Genetics & Stem Cells Authors: Xiaona Lu Kim Ng Filippo Pinto e Vairo James Collins Ronald Cohn Kacie Riley Katherine Agre Ralitza Gavrilova Eric W. Klee Jill A. Rosenfeld Yong-hui Jiang Source Type: research
On the Use of Multiple Imputation Approach in Pediatric Research
In a recent study from Salmon et al reported in The Journal, the investigators assessed the association between clinical chorioamnionitis and neurodevelopmental disorders at 5 years of age in children born preterm.1 The authors did not find a significant association between the two variables based on EPIPAGE 2, a national, population-based cohort study of children born before 35 weeks of gestation in France in 2011. 1 In the database used by the authors, there is a high missing rate (41%) of the primary outcome variable ‘neurodevelopmental disorders’ and high missing rates (between 31.9% and 49.4%) of the secondary out...
Source: The Journal of Pediatrics - May 3, 2024 Category: Pediatrics Authors: Sixia Chen, Michael P. Anderson Tags: Statistics, Explained Source Type: research
Early vs Late Anticoagulation in Acute Ischemic Stroke with Indications Outside Atrial Fibrillation
Current literature lacks guidance on the safety of administering anticoagulation in acute ischemic stroke with emergent indications that require anticoagulation other than atrial fibrillation. Therefore, we tend to rely on studies investigating acute ischemic stroke in atrial fibrillation for anticoagulation recommendations. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 3, 2024 Category: Neurology Authors: Ammar Jumah, Siyuan Fu, Abdalla Jamal Albanna, Utkarsh Agarwal, Michael Fana, Omar Choudhury, Anas Idris, Abdelrahman Elfaham, Zahid Iqbal, Lonni Schultz, Katie Latack, Megan Brady, Dawn Scozzari, Ahmad Riad Ramadan Source Type: research
Consensus practice recommendations for management of gastrointestinal dysfunction in Parkinson disease.
Gastrointestinal (GI) dysfunction is a common non-motor feature of Parkinson disease (PD). GI symptoms may start years before the onset of motor symptoms and impair quality of life. Robust clinical trial data is lacking to guide screening, diagnosis and treatment of GI dysfunction in PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 3, 2024 Category: Neurology Authors: Delaram Safarpour, Natividad Stover, David R. Shprecher, Ali G. Hamedani, Ronald F. Pfeiffer, Henry P. Parkman, Eamonn MM. Quigley, Leslie J. Cloud, On behalf of the Other Non-motor Features Working Group of the Parkinson Study Group Source Type: research
Hyperkinetic Movement Disorder in FBXO28-related Developmental and Epileptic Encephalopathy
Developmental and epileptic encephalopathies (DEEs) are severe pediatric conditions, characterized by epileptic seizures, frequent epileptiform activity on electroencephalogram (EEG), and psychomotor delay or regression. Heterozygous pathogenic variants in FBXO28 gene, encoding a member of the F-box protein family involved in protein ubiquitination cause a developmental and epileptic encephalopathy type 100 (DEE100) [1,2]. So far, only 10 patients with DEE100 have been described worldwide, all presenting refractory epilepsy and severe developmental impairment. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - May 3, 2024 Category: Neurology Authors: Magdalena Krygier, Weronika Tala śka-Liczbik, Marta Zawadzka, Maria Mazurkiewicz-Bełdzińska Source Type: research
The impact of sex on epidemiology, management, and outcome of spontaneous intracerebral hemorrhage (sICH)
Data on sex differences in spontaneous intracerebral hemorrhages are limited. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - May 3, 2024 Category: Neurology Authors: Andrea Sterenstein, Rajeev Garg Source Type: research
Helicobacter Pylori infection in children with cerebral palsy: A cross-sectional study
Children with cerebral palsy (CP) frequently have associated disorders and complications, including gastrointestinal problems. Helicobacter Pylori is a common infection worldwide, frequently associated with gastrointestinal manifestations. (Source: Pediatric Neurology)
Source: Pediatric Neurology - May 3, 2024 Category: Neurology Authors: Sally M. Ismael, Dina S. Atia, Salwa A. Atlam, Abeer A. Eltoukhy, Amira Hamed Darwish Tags: Research Paper Source Type: research
Cancers, Vol. 16, Pages 1771: Sex Differences in Odds of Brain Metastasis and Outcomes by Brain Metastasis Status after Advanced Melanoma Diagnosis
This study showed that males had greater odds of brain metastasis and, among those with brain metastasis, poorer rwOS compared to females, while there were no sex differences in clinical outcomes for those with advanced melanoma without brain metastasis. (Source: Cancers)
Source: Cancers - May 3, 2024 Category: Cancer & Oncology Authors: Gino Cioffi Mustafa S. Ascha Kristin A. Waite Mantas Dmukauskas Xiaoliang Wang Trevor J. Royce Gregory S. Calip Timothy Waxweiler Chad G. Rusthoven Brian D. Kavanagh Jill S. Barnholtz-Sloan Tags: Article Source Type: research
Endothelial dysfunction in neurodegenerative disease: Is endothelial inflammation an overlooked druggable target?
Neurological diseases with a neurodegenerative component have been associated with alterations in the cerebrovasculature. At the anatomical level, these are centred around changes in cerebral blood flow and vessel organisation. At the molecular level, there is extensive expression of cellular adhesion molecules and increased release of pro-inflammatory mediators. Together, these has been found to negatively impact blood-brain barrier integrity. Systemic inflammation has been found to accelerate and exacerbate endothelial dysfunction, neuroinflammation and degeneration. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - May 3, 2024 Category: Allergy & Immunology Authors: Megan Ritson, Caroline Wheeler-Jones, Helen B. Stolp Source Type: research
Mitigation of CXCL10 secretion by metabolic disorder drugs in microglial-mediated neuroinflammation
Metabolic disorders are associated with several neurodegenerative diseases. We previously identified C-X-C motif chemokine ligand 10 (CXCL10), also known as interferon gamma-induced protein 10 (IP-10), as a major contributor to the type I interferon response in microglial-mediated neuroinflammation. Therefore, we hypothesized FDA-approved metabolic disorder drugs that attenuate CXCL10 secretion may be repurposed as a treatment for neurodegenerative diseases. Screening, dose curves, and cytotoxicity assays in LPS-stimulated microglia yielded treprostinil (hypertension), pitavastatin (hyperlipidemia), and eplerenone (hyperte...
Source: Journal of Neuroimmunology - May 3, 2024 Category: Allergy & Immunology Authors: Sophia F. Oliai, Daniel C. Shippy, Tyler K. Ulland Source Type: research
Mental health and justice beyond borders: Global crises, sociopolitical determinants, and contemporary practices in forensic psychiatry
. (Source: International Review of Psychiatry)
Source: International Review of Psychiatry - May 3, 2024 Category: Psychiatry Authors: Alexander SmithAdegboyega OgunwaleHelena Ferreira MouraDinesh BhugraAntonio VentriglioMichael Liebrenza Department of Forensic Psychiatry, University of Bern, Bern, Switzerlandb Forensic Unit, Department of Clinical Services, Neuropsychiatric Hospital, Ar Source Type: research
Sensors, Vol. 24, Pages 2919: Smart Textile Impact Sensor for e-Helmet to Measure Head Injury
der
Concussions, a prevalent public health concern in the United States, often result from mild traumatic brain injuries (mTBI), notably in sports such as American football. There is limited exploration of smart-textile-based sensors for measuring the head impacts associated with concussions in sports and recreational activities. In this paper, we describe the development and construction of a smart textile impact sensor (STIS) and validate STIS functionality under high magnitude impacts. This STIS can be inserted into helmet cushioning to determine head impact force. The designed 2 &times; 2 STIS matrix is com...
Source: Sensors - May 3, 2024 Category: Biotechnology Authors: Manob Jyoti Saikia Arar Salim Alkhader Tags: Article Source Type: research
Sensors, Vol. 24, Pages 2924: Anthropomorphic Tendon-Based Hands Controlled by Agonist & ndash;Antagonist Corticospinal Neural Network
This article presents a study on the neurobiological control of voluntary movements for anthropomorphic robotic systems. A corticospinal neural network model has been developed to control joint trajectories in multi-fingered robotic hands. The proposed neural network simulates cortical and spinal areas, as well as the connectivity between them, during the execution of voluntary movements similar to those performed by humans or monkeys. Furthermore, this neural connection allows for the interpretation of functional roles in the motor areas of the brain. The proposed neural control system is tested on the fingers of a roboti...
Source: Sensors - May 3, 2024 Category: Biotechnology Authors: Francisco Garc ía-Córdova Antonio Guerrero-Gonz ález Fernando Hidalgo-Castelo Tags: Article Source Type: research
