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The description of epileptic seizures in the classical opera
Epilepsy and epileptic seizures have received attention in literature [1 –3] and sometimes even in painting [4–6]. However, with respect to music only very little is known about epilepsy or epileptic seizures as a topic of music. A link between music and epilepsy has been studied for musicogenic epilepsy including musical hallucinations [7,8], for ictal singing [9], and for music in the treatment of epilepsy [10,11]. A few classical composers have been diagnosed with epilepsy such as Hector Berlioz [12], Norbert Burgmüller due to alcoholism [13], George Gershwin due to a brain tumour [14], Hikari Oe [15], and probably...
Source: Seizure: European Journal of Epilepsy - April 20, 2024 Category: Neurology Authors: Stefan Evers Tags: Review Source Type: research

Onchocerciasis-Associated Epilepsy: charting a path forward
The association between onchocerciasis and epilepsy was initially suggested by Casis-Sacre in Chiapas and Oaxaca in Mexico in 1938 [1]. In 1942, Balanzario Rosas, a collaborator of Casis-Sacre, described the “onchocerciasis epileptic syndrome” [2], characterised by epilepsy onset between 9 and 18 years of age, growth failure, neurodevelopmental impairment, a “simian face”, and physical deformities [2]. Later, the association between onchocerciasis and epilepsy was also observed in Bahr El Ghazal , South Sudan [3]. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - April 19, 2024 Category: Neurology Authors: G Van Cutsem, JN Siewe Fodjo, A Hadermann, L-J Amaral, C Trevisan, S Pion, R Colebunders Tags: Review Source Type: research

In Response: Diagnosing functional seizures with a single video-EEG may miss epileptic seizures
We would like to thank Dr Finsterer from Austria for their keen interest in our work [1]. Our article titled “Medication use in patients with functional seizures from a public and a private hospital” [2] aimed to elucidate the pharmaceutical aspects of functional seizure (FS) management as well as to compare these management practices between a private and a public sector hospital. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - April 18, 2024 Category: Neurology Authors: Gabriele Vilyte, James Butler, Victoria Ives-Deliperi, Chrisma Pretorius Source Type: research

Efficacy and safety of phenytoin and levetiracetam for acute symptomatic seizures in children with acute encephalitis syndrome: an open label, randomised controlled trial.
Acute encephalitis syndrome (AES) encompasses a diverse range of inflammatory brain parenchymal diseases that share similar clinical presentations.[1] This syndrome is characterized by the sudden onset of fever and altered sensorium, with or without seizures (excluding febrile seizures).[2] Globally, the reported incidence of encephalitis varies from 6.3 to 7.4 cases per 100,000 individuals across all age groups and 10.5 to 13.8 cases per 100,000 children.[3] (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - April 17, 2024 Category: Neurology Authors: Indar Kumar Sharawat, Vignesh Kaniyappan Murugan, Sanjot Bhardwaj, Apurva Tomar, Lokesh Tiwari, Puneet Dhamija, Prateek Kumar Panda Source Type: research

Association between Pre-diagnostic Serum Uric Acid Levels in Patients with Newly Diagnosed Epilepsy and Conversion Rate to Drug-Resistant Epilepsy within 5 Years: A Common Data Model Analysis
Drug-resistant epilepsy (DRE), characterized by recurrent seizures despite the administration of multiple antiseizure medications (ASMs), poses a substantial challenge in epilepsy management. One of the primary difficulties in managing DRE lies in the absence of reliable biomarkers for identifying patients at risk. The pathomechanism underlying the acquisition of pharmacoresistance in epilepsy remains elusive, although several hypotheses have been proposed, including network degeneration, neuroinflammation, changes in pharmacokinetics and pharmacodynamics, and genetic and/or epigenetic alterations in drug transporters [1,2...
Source: Seizure: European Journal of Epilepsy - April 15, 2024 Category: Neurology Authors: Seungyon Koh, Dong Yun Lee, Jae Myung Cha, Yerim Kim, Hyung Hoi Kim, Hyeon-Jong Yang, Rae Woong Park, Jun Young Choi Source Type: research

Predictors for and use of rescue medication in adults with epilepsy: A multicentre cross-sectional study from Germany
Despite adequate therapy with antiseizure medication (ASM), one-third of patients continue to have seizures, which may evolve into seizure emergencies, including seizure clusters, prolonged episodes, and status epilepticus, which represent life-threatening neurological emergencies with serious cerebral and systemic sequelae.[1,2] Rescue medications are given as needed to disrupt the progression of a seizure and forestall what would otherwise be a more prolonged or severe clinical event.[3,4]Benzodiazepines, such as diazepam, lorazepam, and midazolam, are positive allosteric modulators of GABAA receptors, whose activation l...
Source: Seizure: European Journal of Epilepsy - April 13, 2024 Category: Neurology Authors: Margarita Maltseva, Felix Rosenow, Felix von Podewils, Lena Habermehl, Lisa Langenbruch, Laura Bierhansl, Susanne Knake, Juliane Schulz, Bernadette Gaida, Leena K ämppi, Catrin Mann, Adam Strzelczyk Source Type: research

Extreme photosensitivity and self-induced seizures with dramatic response to add-on Lorazepam in patient with WDR45 encephalopathy
Neurodegeneration with brain iron accumulation (NBIA) encompasses a range of inherited neurological disorders, each displaying a diverse array of symptoms. A specific subtype within this spectrum is known as beta-propeller protein-associated neurodegeneration (BPAN), which arises due to mutations in the WDR45 gene. This particular variant of NBIA presents with childhood developmental delay (DD), notably characterized by expressive speech delays and recurrent seizures. Of note BPAN is the sole X-linked form of NBIA, typically exhibiting a more severe course of disease or even fatality in males [1]. (Source: Seizure: Europea...
Source: Seizure: European Journal of Epilepsy - April 13, 2024 Category: Neurology Authors: Ekaterine Kurua, Tamar Gachechiladze, Nazhi Tabatadze, Mariam Melikishvili, Gia Melikishvili, Jo M Wilmshurst Tags: Short communication Source Type: research

Service users' preferences and feasibility – which alternative care pathway for adult ambulance users achieves the optimal balance? Workshops for the COLLABORATE project
Studies from around the world show ambulances frequently attend to adults with epilepsy and convey them to hospital emergency departments (EDs) [1 –4]. In England, suspected seizures are the 7th most common presentation to the ambulance service; [2,5] ∼70% are conveyed to ED. The population attending ED for a suspected seizure is mixed and includes people with varying needs. For some, attendance at ED will be important, potentially lifesav ing. Having said this, ED attendance for most seen by ambulance for a suspected seizure will offer minimal benefit since most have established (rather than new) epilepsy; present wit...
Source: Seizure: European Journal of Epilepsy - April 10, 2024 Category: Neurology Authors: Adam J. Noble, Beth Morris, Pete Dixon, Amy Mathieson, Leone Ridsdale, Myfanwy Morgan, Jon Dickson, Steve Goodacre, Mike Jackson, Dyfrig Hughes, Anthony Marson, Emily Holmes Source Type: research

Developing an alternative care pathway for emergency ambulance responses for adults with epilepsy: A Discrete Choice Experiment to understand which configuration service users prefer. Part of the COLLABORATE project
Accident& Emergency Department (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - April 10, 2024 Category: Neurology Authors: Emily Holmes, Pete Dixon, Amy Mathieson, Leone Ridsdale, Myfanwy Morgan, Alison McKinlay, Jon Dickson, Steve Goodacre, Mike Jackson, Deborah Foster, Kristy Hardman, Steve Bell, Anthony Marson, Dyfrig Hughes, Adam J. Noble Source Type: research

Effectiveness and Safety of Lacosamide in Pediatric Patients with Epilepsy Under Four Years: Results from a Prospective Cohort Study in China
Epilepsy is a serious neurological condition, affected over 65 million people worldwide.[1] The median incidence rate of epilepsy is 82.2 per 100,000 in age group 0-14 years, which is higher than the older group.[2] Diagnosing, classifying, and reporting seizure frequency are typically challenges for pediatric patients in clinical practice and research of epilepsy.[3] There are a few placebo-control randomized clinical trials demonstrating efficacy and well tolerance of LCM in adults and adolescents patient. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - April 10, 2024 Category: Neurology Authors: Li Xiong, Huan He, Duan Wang, Tailin Liu, Nong Xiao Source Type: research

Association of minor electrocardiographic (ECG) abnormalities with epilepsy duration in children: a manifestation of the epileptic heart?
A myriad of ictal and interictal cardiac alterations has been described in individuals with epilepsy, such as rhythm disturbances, increased arrhythmogenic potential, and impaired cardiac function [1 –16]. Increasing evidence indicates that adults with epilepsy may be at a higher risk for major cardiovascular events such as myocardial infarction, arrhythmias, and sudden cardiac death [17–21]. Together, these observations in adults support the concept of “the epileptic heart”: cardiac str uctural and functional abnormalities as result of chronic epilepsy, which may lead to potentially deleterious sequelae [22]. (Sou...
Source: Seizure: European Journal of Epilepsy - April 9, 2024 Category: Neurology Authors: Brittnie Bartlett-Lee, Leslie Dervan, Christina Miyake, R. Scott Watson, See Wai Chan, Anne E. Anderson, Yi-Chen Lai Source Type: research

Barriers and facilitators to healthcare practitioners providing care for pregnant women with epilepsy: A systematic review and narrative synthesis
Epilepsy is one of the most common long term conditions affecting women of child-bearing age, impacting approximately 1 in 200 (0.5%) pregnancies in the UK (1). Global figures of the prevalence of epilepsy in pregnancy are difficult to estimate, however it is suggested that between 0.3 and 0.8% of all gestations are impacted (2). Neurological conditions are the fourth highest cause of all maternal deaths in the UK and epilepsy related deaths show no significant sign of decreasing (3). The risk of mortality and morbidity to women with epilepsy and their babies are greater than for women without epilepsy (3). (Source: Seizur...
Source: Seizure: European Journal of Epilepsy - April 9, 2024 Category: Neurology Authors: Anita Hughes, Annalise Weckesser, Elaine Denny, Fatima Junaid, Cathy Nelson-Piercy, Mairead Black, John Allotey, Shakila Thangaratinam, Judith Dyson Tags: Review Source Type: research

Replacement of Traditional Vagus Nerve Stimulation with Cardiac-Based Device and Seizure Reduction: A Systematic Review and Meta-Analysis
Epilepsy is a highly prevalent neurological condition, affecting an estimated 50 million individuals worldwide[1 –3]. Notwithstanding the wide range of available antiepileptic drugs, around 30% of individuals with epilepsy experience inadequate seizure control[4–6]. Vagus nerve stimulation (VNS) has been established as a safe and effective treatment strategy for patients with refractory epilepsy who are in eligible for surgical intervention. (Source: Seizure: European Journal of Epilepsy)
Source: Seizure: European Journal of Epilepsy - April 6, 2024 Category: Neurology Authors: Jordana Borges Camargo Diniz, Francisco Alfonso Rodriguez Elvir, La ís Silva Santana, Sávio Batista, Luisa Mothe Glioche Gasparri, João Paulo Mota Telles, Allan Dias Polverini Tags: Review Source Type: research

A comparison of cenobamate with other newer antiseizure medications for adjunctive treatment of focal-onset seizures: A systematic review and network meta-analysis
Focal-onset seizures (FOS) in adults are controlled using anti-seizure medications (ASMs), with monotherapy being the gold standard for management of newly diagnosed epilepsies. Despite this optimal approach, over 50% of patients do not achieve seizure-free outcomes with initial monotherapy [1]. For these patients, use of alternative monotherapies followed by combination therapies using an additional ASM as an adjunctive is recommended [1,2]. Drug-resistant epilepsy affects a significant portion of the epilepsy population [3], and it can be challenging to manage seizures with conventional medications, thus, underscoring th...
Source: Seizure: European Journal of Epilepsy - April 5, 2024 Category: Neurology Authors: Stuart Mulheron, Thomas P. Leahy, Megan McStravick, Rachael Doran, Norman Delanty Source Type: research

An automated algorithm for stereoelectroencephalography electrode localization and labelling
Here, we introduce a novel algorithm and pipeline designed for the rapid and precise localization of stereoelectroencephalography (sEEG) electrodes. sEEG is increasingly utilized for localization of seizure foci, functional mapping, and neurocognitive research [1]. This is largely due to its ability to target deep and difficult to reach anatomical locations and offers unparalleled opportunities to study in vivo brain function with a high signal-to-noise ratio [2]. It is not surprising, therefore, that sEEG is leveraged in various neuroscientific studies and clinical applications, including epilepsy research and surgery. (S...
Source: Seizure: European Journal of Epilepsy - April 4, 2024 Category: Neurology Authors: Simeon M Wong, Olivia N Arski, George M Ibrahim Tags: Short communication Source Type: research