Comparison of aspiration catheter performance using adaptive pulsatile aspiration in an < em > in vitro < /em > thrombectomy model
CONCLUSION: APA via the Von Vascular, Inc. ALGO® pump achieved a high success rate in an in vitro MT model. All catheters tested with the pump achieved complete reperfusion in all trials, and complete clot ingestion into the pump was seen in a majority of trials. The promising in vitro performance of APA using multiple catheters warrants future in vivo investigation.PMID:38693768 | DOI:10.1177/15910199241250082 (Source: Interventional Neuroradiology)
Source: Interventional Neuroradiology - May 2, 2024 Category: Radiology Authors: Michael A Silva Sai Sanikommu Pedro Bartkevitch Rodrigues Manning Hanser Ryan Ortiz Victor Gamez Robert M Starke Source Type: research
Use and experienced effectiveness of non-pharmacological treatments for chronic spinal cord injury related pain in The Netherlands: A cross-sectional survey
CONCLUSION: Patients with SCI experiencing pain often use non-pharmacological treatments. Most treatments were described as moderately effective. Research on specific non-pharmacological treatments and different types of pain separately is needed to further determine the effectiveness of non-pharmacological treatments.PMID:38695723 | DOI:10.1080/10790268.2024.2345448 (Source: Journal of Spinal Cord Medicine)
Source: Journal of Spinal Cord Medicine - May 2, 2024 Category: Orthopaedics Authors: Tim C Crul Aline J Hakbijl-van der Wind Charlotte M van Laake-Geelen Johanna Ma Visser-Meily Marcel Wm Post Janneke M Stolwijk-Sw üste Source Type: research
Effect of repetitive peripheral magnetic stimulation of the common fibular nerve on the soleus muscle Hoffmann reflex
Conclusion] The change in the Hoffmann reflex amplitude may have been caused by the magnetic stimulation to I-a sensory fibers on the common fibular nerve, suggesting that magnetic stimulation induces reciprocal inhibition of motor neurons through synapses in the spinal cord.PMID:38694014 | PMC:PMC11060763 | DOI:10.1589/jpts.36.278 (Source: Physical Therapy)
Source: Physical Therapy - May 2, 2024 Category: Physiotherapy Authors: Kazunori Morozumi Katsuyuki Morishita Michio Tojima Takashi Inomata Source Type: research
Clinical applicability of automated tractography for stroke rehabilitation: Z-score conversion of fractional anisotropy
Conclusion] In this study, the Z-score findings related to stroke symptoms align with those reported in the literature, indicating the appropriateness of the methodology used and its potential in future applications.PMID:38694010 | PMC:PMC11060757 | DOI:10.1589/jpts.36.319 (Source: Physical Therapy)
Source: Physical Therapy - May 2, 2024 Category: Physiotherapy Authors: Midori Mochizuki Yuki Uchiyama Kazuhisa Domen Tetsuo Koyama Source Type: research
Novel CCR3-targeted cyclic peptides as potential therapeutic agents for age-related macular degeneration via inhibiting angiogenesis and reducing retinal photoreceptor damage
Bioorg Chem. 2024 Apr 26;147:107405. doi: 10.1016/j.bioorg.2024.107405. Online ahead of print.ABSTRACTThe prolonged intravitreal administration of anti-vascular endothelial growth factor (VEGF) drugs is prone to inducing aberrant retinal vascular development and causing damage to retinal neurons. Hence, we have taken an alternative approach by designing and synthesizing a series of cyclic peptides targeting CC motif chemokine receptor 3 (CCR3). Based on the binding mode of the N-terminal region in CCR3 protein to CCL11, we used computer-aided identification of key amino acid sequence, conformational restriction through dif...
Source: Bioorganic Chemistry - May 2, 2024 Category: Chemistry Authors: Yuanyuan Li Shu'ai Guo Xinjing Wu Jiale Wan Yonghui Guan Chenghui Luo Qin Chen Hongyu Jiang Haiyan Lin Hai Qian Wei Shi Wen Fan Source Type: research
Nerve transfer for upper extremity reanimation in people with spinal cord injury: A 2-year follow-up case series
CONCLUSIONS: NT represents a functional surgery option with few complications for the resuscitation of upper limbs in persons with tetraplegia.PMID:38695737 | DOI:10.1080/10790268.2024.2344313 (Source: Journal of Spinal Cord Medicine)
Source: Journal of Spinal Cord Medicine - May 2, 2024 Category: Orthopaedics Authors: Silvia Olivi Paola Paglierani Elisa Maietti Paola Rucci Gaia Musumeci Carlotte Kiekens Jacopo Visani Carlo Sacco Source Type: research
Bicycling for Rehabilitation of Persons With Parkinson Disease: A Scoping Review
CONCLUSIONS: The literature on bicycling for PwPD has evolved from speed to aerobic studies. The terminology describing types of bicycling was simplified. Of all the outcomes reported, reduction of disease severity achieved the highest frequency of clinical meaningful improvements. Bicycling was comparable with other forms of aerobic training for walking speed and endurance. Opportunities for translation to practice and research are presented.VIDEO ABSTRACT AVAILABLE: for more insights from the authors (see the Video, Supplemental Digital Content 1 available at: http://links.lww.com/JNPT/A462).PMID:38693613 | DOI:10.1097/N...
Source: Physical Therapy - May 2, 2024 Category: Physiotherapy Authors: John L Palmieri Lesley Jones Margaret Schenkman Judith E Deutsch Source Type: research
Preoperative assessment of lymph nodal metastases with [ < sup > 68 < /sup > Ga]Ga-DOTATOC PET radiomics for improved surgical planning in well-differentiated pancreatic neuroendocrine tumours
CONCLUSION: In this study, [68Ga]Ga-DOTATOC PET radiomics allowed to increase diagnostic sensitivity in detecting LN metastases from 24 to 77% in NF-PanNET patients candidate to surgery. Especially in case of micrometastatic involvement, this approach might assist clinicians in a better patients' stratification.PMID:38696129 | DOI:10.1007/s00259-024-06730-w (Source: Molecular Medicine)
Source: Molecular Medicine - May 2, 2024 Category: Molecular Biology Authors: Paola Mapelli Carolina Bezzi Francesca Muffatti Samuele Ghezzo Carla Canevari Patrizia Magnani Marco Schiavo Lena Anna Battistella Paola Scifo Valentina Andreasi Stefano Partelli Arturo Chiti Massimo Falconi Maria Picchio Source Type: research
Team-based rehabilitation after mild traumatic brain injury - description of the clinical pathway
CONCLUSION: A small proportion of participants received much higher number of sessions, consistent with intractable issues after mTBI. High attendance rates indicate the predominantly telehealth-delivered model was feasible. The clinical approach included early prioritizing of discipline input and follow-up after discharge.PMID:38695320 | DOI:10.1080/02699052.2024.2347570 (Source: Brain Injury)
Source: Brain Injury - May 2, 2024 Category: Neurology Authors: Simon J Mills Hannah Halstead Joanne Howie Selena Hutchins Leah Forte David Unsworth Terri Walters Miranda Jelbart Beverley Dodd Maayken van den Berg Maggie Killington Source Type: research
Real-world environmental enrichment rehabilitation paradigm in people with severe traumatic brain injury: a pilot feasibility study
CONCLUSION: The Café was a comprehensive EE-based intervention that was feasible, safe, and has the potential to enhance motor and cognitive function in individuals with brain injury.PMID:38695288 | DOI:10.1080/02699052.2024.2347551 (Source: Brain Injury)
Source: Brain Injury - May 2, 2024 Category: Neurology Authors: Devina S Kumar Barry A Bodt James C Galloway Source Type: research
The complex regulation of Slo1 potassium channels from a structural perspective
Biol Chem. 2024 May 3. doi: 10.1515/hsz-2024-0037. Online ahead of print.ABSTRACTFast and regulated potassium efflux by Slo1 channels is crucial in many tissues in animals including neurons, the kidney and smooth muscle. During the last decade, structures have revealed many details about the gating mechanism and regulation of these large and complex molecular machines. This review summarizes these findings and the current knowledge about the intricate regulation of these important channels. Slo1 integrates sensing of the membrane potential via a voltage-sensor domain that undergoes subtle but significant structural rearran...
Source: Biological Chemistry - May 2, 2024 Category: Chemistry Authors: Tobias Raisch Source Type: research
Lower Limb Proprioception in Low Back Pain and Its Relationship With Voluntary Postural Control
This study aimed to investigate whether patients with low back pain (LBP) had impaired lower limb proprioception and its association with somatosensory acuity. Thirty patients with LBP and 30 asymptomatic people volunteered, using Sway Discrimination Apparatus tests to assess somatosensory acuity during voluntary anteroposterior and mediolateral postural sway. Results showed significantly reduced somatosensory acuity in mediolateral sway in LBP patients (p = 0.005) with ankle, knee, and hip proprioception showing significantly impairment compared to asymptomatic controls (all p ≤ 0.012). Regression analysis showed that a...
Source: Journal of Motor Behavior - May 2, 2024 Category: Neurology Authors: Zhengquan Chen Oren Tirosh Jia Han Roger Adams Doa El-Ansary Adrian Pranata Source Type: research
Very unusual extremely high ferritin with cytokine release syndrome in a patient with hematological malignancy after experimental chimeric antigen receptor (CAR)-T-Cell therapy
CONCLUSIONS: Cytokine release syndrome after experimental (CAR) T cell therapy may cause extremely elevated ferritin and hemophagocytic lymphohistiocytosis -like syndrome.PMID:38697457 | DOI:10.1016/j.cca.2024.119704 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - May 2, 2024 Category: Chemistry Authors: Robert Hoyt Zhan Ye Amitava Dasgupta Source Type: research
Hydroxytyrosol acetate from olive leaves ( < em > Olea Europaea < /em > L.) induces apoptosis via mitochondrial pathway in BEL7402 cell line
Nat Prod Res. 2024 May 1:1-4. doi: 10.1080/14786419.2024.2348679. Online ahead of print.ABSTRACTHydroxytyrosol acetate is one of the polyphenolic compounds in olive leaves. Hydroxytyrosol acetate has a variety of biological activities, such as antibacterial, antioxidant, anti-inflammatory, cognitive improvement and neuroprotective effects. However, there is no report on the antitumor activity and the antitumor mechanism of hydroxytyrosol acetate. In our study, we studied the antitumor activity of hydroxytyrosol acetate by MTT assay and determined the antitumor mechanism by DNA ladder assay, mitochondrial membrane potential...
Source: Natural Product Research - May 2, 2024 Category: Biochemistry Authors: Jianteng Wei Jianfang Wei Shuxian Wang Source Type: research
Chronic traumatic encephalopathy-the first neuropathological report in New Zealand
N Z Med J. 2024 May 3;137(1594):75-78. doi: 10.26635/6965.6421.NO ABSTRACTPMID:38696835 | DOI:10.26635/6965.6421 (Source: New Zealand Medical Journal)
Source: New Zealand Medical Journal - May 2, 2024 Category: General Medicine Authors: Fen-Lan Cherry Chang Richard Lm Faull Maurice A Curtis Andrew M Chancellor Michael E Buckland Clinton P Turner Source Type: research
