Challenging treatment resistance
Nervenarzt. 2024 May;95(5):405-406. doi: 10.1007/s00115-024-01645-1. Epub 2024 May 3.NO ABSTRACTPMID:38700716 | DOI:10.1007/s00115-024-01645-1 (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 3, 2024 Category: Neurology Authors: Ren é Hurlemann Katharina Domschke Source Type: research
Introduction to the topic: German Center for Mental Health (DZPG)-A new German health center
Nervenarzt. 2024 May;95(5):448-449. doi: 10.1007/s00115-024-01642-4. Epub 2024 May 3.NO ABSTRACTPMID:38700717 | DOI:10.1007/s00115-024-01642-4 (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 3, 2024 Category: Neurology Authors: Andreas Heinz Andreas Meyer-Lindenberg Source Type: research
Mitteilungen der DGPPN 05/2024
Nervenarzt. 2024 May;95(5):494-496. doi: 10.1007/s00115-024-01664-y.NO ABSTRACTPMID:38700718 | DOI:10.1007/s00115-024-01664-y (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 3, 2024 Category: Neurology Source Type: research
A combined cross-sectional analysis and case-control study evaluating tick-borne encephalitis vaccination coverage, disease and vaccine effectiveness in children and adolescents, Switzerland, 2005 to 2022
ConclusionsEven children younger than 5 years can experience severe TBE. Incomplete and complete vaccination protect against neurological manifestations of the disease. Complete vaccination offers durable protection up to 10 years against TBE.PMID:38699900 | DOI:10.2807/1560-7917.ES.2024.29.18.2300558 (Source: Euro Surveill)
Source: Euro Surveill - May 3, 2024 Category: Infectious Diseases Authors: Kyra D Zens Ekkehardt Altpeter Monica N Wymann Annora Mack Nora B Baer Sarah R Haile Robert Steffen Jan S Fehr Phung Lang Source Type: research
Severe heart failure and intracardiac thrombosis: going beyond the appearance for diagnosis and treatments
We describe the case of a 45-year-old female affected by asthma and nasal polyposis who presented to the emergency department because of worsening dyspnea and paresthesia of the left lower limb. Comprehensive instrumental examinations revealed the presence of severe left ventricle dysfunction, intra-cardiac thrombus, deep vein thrombosis, pulmonary embolism, lung infiltrates, polyserositis, and neurological involvements. Finally, the patient was diagnosed with eosinophilic granulomatosis with polyangiitis (EGPA), formerly Churg-Strauss syndrome, a rare vasculitis of small-medium blood vessels with several organ involvement...
Source: Monaldi Archives for Chest Disease - May 3, 2024 Category: Respiratory Medicine Authors: Andrea Segreti Sara Mastroberardino Lorenzo Frau Alessandro Appetecchia Luca D'Antonio Danilo Ricciardi Gian Paolo Ussia Francesco Grigioni Source Type: research
Validation of a Simplified Model for Subarachnoid Hemorrhage in Mice
CONCLUSIONS: This simplified model of SAH elicits pathological changes consistent with those described for more complex models in the literature. Therefore, it can be used in future preclinical studies examining the pathophysiology of SAH and novel treatment options.PMID:38701138 | DOI:10.3233/CH-231997 (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - May 3, 2024 Category: Hematology Authors: Sophie Tanner Juan Zhou Bashir Bietar Christian Lehmann Source Type: research
Emerging evidence of context-dependent synapse elimination by phagocytes in the CNS
J Leukoc Biol. 2024 May 3:qiae098. doi: 10.1093/jleuko/qiae098. Online ahead of print.ABSTRACTPrecise synapse elimination is essential for the establishment of a fully developed neural circuit during brain development and higher function in adult brain. Beyond immune and nutrition support, recent groundbreaking studies have revealed that phagocytic microglia and astrocytes can actively and selectively eliminate synapses in normal and diseased brains, thereby mediating synapse loss and maintaining circuit homeostasis. Multiple lines of evidence indicate that the mechanisms of synapse elimination by phagocytic glia are not u...
Source: Journal of Leukocyte Biology - May 3, 2024 Category: Hematology Authors: Fang-Shuai Shen Cui Liu Hui-Zhe Sun Xin-Yi Chen Yan Xue Lei Chen Source Type: research
Prognostic biomarker NRG2 correlates with autophagy and epithelial ‑mesenchymal transition in breast cancer
Oncol Lett. 2024 Apr 23;27(6):277. doi: 10.3892/ol.2024.14410. eCollection 2024 Jun.ABSTRACTBreast cancer (BRCA) is a leading cause of death in women worldwide, accounting for 31% of female cancer. Autophagy plays a crucial role in cancer progression, however, the function of autophagy-related gene neuroregulatory protein 2 (NRG2) in BRCA and its underlying molecular mechanisms remain unclear. In the present study, the expression of the NRG2 gene in BRCA was significantly down-regulated compared with the normal controls. The low expression level of NRG2 was related to poor survival rate of BRCA. The receiver operating char...
Source: Oncology Letters - May 3, 2024 Category: Cancer & Oncology Authors: Ruijie Zhou Jinjin Dai Runlong Zhou Mengyi Wang Xiaotong Deng Qing Zhuo Zhenrong Wang Fan Li Di Yao Yao Xu Source Type: research
Comparison of Guillain-Barre Syndrome Cases during and Prior to the COVID-19 Pandemic: A Multicentric Study
DISCUSSION: The number of GBS hospital admissions, clinical presentation, electrodiagnostic features, and short-term outcomes did not differ significantly between the prepandemic and postpandemic periods; a slightly higher incidence of in-hospital complications was observed during the pandemic period. How to cite this article: Panicker P, R D, V AG, et al. Comparison of Guillain-Barre Syndrome Cases during and Prior to the COVID-19 Pandemic: A Multicentric Study. J Assoc Physicians India 2023;71(9):69-71.PMID:38700304 | DOI:10.59556/japi.71.0317 (Source: Journal of the Association of Physicians of India)
Source: Journal of the Association of Physicians of India - May 3, 2024 Category: General Medicine Authors: Praveen Panicker Dileep R Abdul V Gafoor Prasanth S R Thomas Iype James Jose Antony Stanley Source Type: research
A Prospective Observational Study of Autoimmune Encephalitis in Northwestern India
CONCLUSION: Autoimmune encephalitis (AIE), a potentially treatable immune-responsive entity, is a common neurological problem and may be an answer to a large number of cases having unexplained encephalitis. Good clinical acumen and knowledge are required for early diagnosis and treatment of this potentially reversible disorder. How to cite this article: Sharma B, Paul M, Bagaria AK. A Prospective Observational Study of Autoimmune Encephalitis in Northwestern India. J Assoc Physicians India 2023;71(9):39-44.PMID:38700300 | DOI:10.59556/japi.71.0312 (Source: Journal of the Association of Physicians of India)
Source: Journal of the Association of Physicians of India - May 3, 2024 Category: General Medicine Authors: Bhawna Sharma Madhuparna Paul Amit K Bagaria Source Type: research
Effect of Rotenone on the Neurodegeneration among Different Models
Curr Drug Targets. 2024 May 2. doi: 10.2174/0113894501281496231226070459. Online ahead of print.ABSTRACTRotenone is a naturally occurring plant product used as an insecticide, pesticide and piscicide. It is lipophilic in nature and can cross the blood-brain barrier and induce the degeneration of neurons. It inhibits the mitochondrial respiratory chain complex I and stops the transfer of electrons. It induces ROS generation, which impairs mitochondrial activity. Rotenone is a toxic agent which causes the death of neurons. The present review describes the effect of rotenone on neurodegeneration with an emphasis on behavioral...
Source: Current Drug Targets - May 3, 2024 Category: Drugs & Pharmacology Authors: Iqra Subhan Yasir Hasan Siddique Source Type: research
Safety and Efficacy of Surgical Implantation of Intrathecal Drug Delivery Pumps in Patients With Cancer With Refractory Pain
CONCLUSION: Our study demonstrates that ITP implantation for the treatment of cancer-related pain is a safe and effective method of pain palliation with a low complication rate. Future prospective studies are required to determine the optimal timing of ITP implantation.PMID:38700319 | DOI:10.1227/neu.0000000000002978 (Source: Cancer Control)
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Graham M Winston Jeffrey H Zimering Christopher W Newman Anne S Reiner Noel Manalil Natasha Kharas Amitabh Gulati Neal Rakesh Ilya Laufer Mark H Bilsky Ori Barzilai Source Type: research
Early therapy evaluation of intra-arterial trastuzumab injection in a human breast cancer xenograft model using multiparametric MR imaging
CONCLUSION: IA treatment with trastuzumab potentially affects the early response to treatment, including decreased tumor growth and decrease of Ktrans, in a preclinical brain tumor model.PMID:38701062 | DOI:10.1371/journal.pone.0300171 (Source: Cancer Control)
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Bo Kyu Kim Byungjun Kim Sung-Hye You Moon-Sun Jang Geun Ho Im Keon-Ha Kim Source Type: research
Distribution of Nerve Fibers in Abdominal Wall Endometriosis and Their Clinical Significance
CONCLUSION: This study demonstrated an increased immunoreactive nerve fiber density located in AWE lesions compared to normal abdominal wall scars. Further high-quality studies are needed to investigate the mechanisms responsible for pain in women with endometriosis.PMID:38699067 | PMC:PMC11063460 | DOI:10.2147/JPR.S453148 (Source: Cancer Control)
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Chenyu Zhang Yi Dai Junji Zhang Xiaoyan Li Shuangzheng Jia Jinghua Shi Jinhua Leng Source Type: research
Antioxidant network-based signatures cluster glioblastoma into distinct redox-resistant phenotypes
CONCLUSION: In summary, we provide a set of transcriptional signatures that unveil the antioxidant potential of GBM, offering a promising prognostic application and a guide for therapeutic strategies in GBM therapy.PMID:38698847 | PMC:PMC11063242 | DOI:10.3389/fimmu.2024.1342977 (Source: Cancer Control)
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Yihan Yang Sanket More Frederik De Smet Steven De Vleeschouwer Patrizia Agostinis Source Type: research
