COVID-19 and restrictive lung disease: A deadly combo to trip off the fine balance.
Authors: Sahu KK, Mishra AK, Martin K, Chastain I Abstract Coronavirus Disease (COVID-19) pandemic has so far led to innumerable deaths worldwide. The risk factors so far that have been most studied as poor prognostic factors are old age, individuals with multiple comorbidities and immunocompromised patients. Amongst the chronic lung diseases, most patients with COVID-19 reported so far had asthma, chronic obstructive pulmonary disease (COPD), and interstitial lung disease. Herein, we discuss the significance of restrictive lung disease during the COVID-19 pandemic as a potential risk factor via...
Source: Monaldi Archives for Chest Disease - July 2, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Cardio-oncology: the new frontier of clinical and preventive cardiology.
Authors: Paris S, Tarantini L, Navazio A, Faggiano P Abstract Even if cancer and cardiovascular diseases are considered two distinct diseases, an intricate interconnection between these conditions has been established. Increased risk of malignancy has been identified in patients with cardiovascular disease, as well as a greater propensity to the development of cardiovascular diseases has been observed in patients with cancer. The development of cardiotoxicity following exposure to certain anticancer drugs only partially explains this relationship. Shared risk factors and common pathogenic mechanisms suggest the exi...
Source: Monaldi Archives for Chest Disease - June 25, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Italian suggestions for pulmonary rehabilitation in COVID-19 patients recovering from acute respiratory failure: results of a Delphi process.
Authors: Vitacca M, Lazzeri M, Guffanti E, Frigerio P, D'Abrosca F, Gianola S, Carone M, Paneroni M, Ceriana P, Pasqua F, Banfi P, Gigliotti F, Simonelli C, Cirio S, Rossi V, Beccaluva CG, Retucci M, Santambrogio M, Lanza A, Gallo F, Fumagalli A, Mantero M, Castellini G, Calabrese M, Castellana G, Volpato E, Ciriello M, Garofano M, Clini E, Ambrosino N, Arir Associazione Riabilitatori dell'Insufficienza Respiratoria Sip Società Italiana di Pneumologia Aifi Associazione Italiana Fisioterapisti And Sifir Società Italiana di Fisioterapia E Riabilitazione OBOAAIPO Abstract There is a need of consensus abo...
Source: Monaldi Archives for Chest Disease - June 25, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Clinical-Cytological-Grading and phenotyping in patients with chronic rhinosinusitis with nasal polyps: the relevance in clinical practice.
Authors: Gelardi M, Porro G, Quaranta V, Quaranta N, Cassano M, Ciprandi G, Study Group On CRSwNP I Abstract Chronic rhinosinusitis (CRS) includes two main phenotypes: without nasal polyps (CRSsNP) and with nasal polyps (CRSwNP). CRSwNP may be associated with comorbidity, mainly concerning asthma, aspirin intolerance, and allergy. CRSwNP patients may also be evaluated by clinical-cytological grading (CCG). The current study investigated the prevalence and characteristics of the different CCG and phenotypes in CRSwNP outpatients examined in clinical practice. This retrospective cross-sectional study enrolled 791 con...
Source: Monaldi Archives for Chest Disease - June 25, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Safe chest tube placement in a patient with tension pneumothorax receiving rivaroxaban therapy for non-valvular atrial fibrillation.
This report describes a case in which emergency placement of a tube thoracostomy, in a patient with type 2 respiratory failure due to left tension pneumothorax and receiving the anticoagulant rivaroxaban, in the pharmacokinetics phase with greater anticoagulant effect, did not result in bleeding greater than that typically encountered during such interventions. The procedure ended successfully with no acute complications. PMID: 32548992 [PubMed - in process] (Source: Monaldi Archives for Chest Disease)
Source: Monaldi Archives for Chest Disease - June 19, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Sleepless in COVID-19: how not to lose sleep in lockdowns.
Authors: Yadav SR, Kumar R, Kumar A, Ish P, Gupta N, Chakrabarti S Abstract The corona virus disease 2019 (COVID-19) outbreak started in December 2019 in Wuhan, China, and spread all over the world leading to declaration of a pandemic by World Health Organization (WHO) on 11th March 2020. Most countries around the world have been on lockdown in an effort to halt the spread of virus. People around the world have been pushed into uncharted waters of uncertainty, fear, anxiety, stress and depression due to economic crash down, job losses and fear for their own health and that of their loved ones. There is a known asso...
Source: Monaldi Archives for Chest Disease - June 19, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Cardiac rehabilitation activities during the COVID-19 pandemic in Italy. Position Paper of the AICPR (Italian Association of Clinical Cardiology, Prevention and Rehabilitation).
Authors: Mureddu GF, Ambrosetti M, Venturini E, La Rovere MT, Mazza A, Pedretti R, Sarullo F, Fattirolli F, Faggiano P, Giallauria F, Vigorito C, Angelino E, Brazzo S, Ruzzolini M Abstract The COVID-19 outbreak is having a significant impact on both cardiac rehabilitation (CR) inpatient and outpatient healthcare organization. The variety of clinical and care scenarios we are observing in Italy depends on the region, the organization of local services and the hospital involved. Some hospital wards have been closed to make room to dedicated beds or to quarantine the exposed health personnel. In other cases, CR units ...
Source: Monaldi Archives for Chest Disease - June 19, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Cerebrovascular events in COVID-19 patients.
Authors: Mishra AK, Sahu KK, George AA, Sargent J, Lal A Abstract Neurological manifestations in patients with COVID-19 are more frequently being reported. Cerebrovascular events have been reported in around 3% of patients. In this review we summarize the published literature on cerebrovascular events in patients with COVID-19 as available on the PubMed database. So far, 3 studies have reported cerebrovascular events. Cerebrovascular events were identified on screening patients with decreased consciousness or in the presence of focal neurological deficits. These events were common in elderly, critically ill patient...
Source: Monaldi Archives for Chest Disease - June 13, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Idiopathic pulmonary hemosiderosis - A rare cause of chronic anemia.
Authors: Butt A, Ahmed R, Sheikh MDA, Khan O, Iqbal N, Rahman AJ, Khan JA Abstract Idiopathic pulmonary hemosiderosis (IPH) is a rare disease marked by alveolar bleeding and accumulation of hemosiderin in the lungs. Here we present three cases of IPH. The first case is of a 26-year-old male with anemia, hemoptysis and dyspnea. Bronchoscopy confirmed diffuse alveolar hemorrhage (DAH). A diagnosis of IPH was made after ruling out other causes of DAH and observing good response to steroids. The patient's condition improved with prednisolone and azathioprine. The second case is of 26-year-old female with severe anemia....
Source: Monaldi Archives for Chest Disease - June 10, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

High flow nasal cannula oxygen therapy in adults with COVID-19 respiratory failure. A case report.
Authors: Karamouzos V, Fligou F, Gogos C, Velissaris D Abstract The novel corona virus (SARS-CoV-2) continuous to spread around the globe causing high mortality, tremendous stress on healthcare systems and an unprecedented disruption of everyday life with unpredictable socioeconomic ramifications. The diseaseis typically affecting the respiratory system and some patients will develop refractory hypoxemic respiratory insufficiency requiring mechanical ventilation. The role of non-invasive ventilation (NIV), high flow nasal cannula (HFNC) or continuous positive airway pressure devices (C-PAP) in the treatment of the ...
Source: Monaldi Archives for Chest Disease - June 10, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Mis-infodemic: The Achilles' heel in combating the COVID-19 pandemic in an Indian perspective.
Authors: Sahoo SS, Sahu DP, Kankaria A Abstract In this ongoing SARS-CoV2 Corona virus pandemic, we are witnessing an uninhibited spread of mis-information on various social media platforms. This spread of mis-information or "mis-infodemic" is playing a negative role in our fight against the virus with far reaching consequences. International organizations like the WHO and other governmental organizations have geared up to the occasion to limit the spread of these and bring clarity in this context. In this time of crisis, risk communication is vital in the communication between organizations/government an...
Source: Monaldi Archives for Chest Disease - June 6, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

COVID-19: a review.
Authors: Madabhavi I, Sarkar M, Kadakol N Abstract The enduring epidemic outbreak which started in Wuhan city of China, in December 2019 caused by the 2019 novel coronavirus (COVID- 19) or the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has created a dangerous and deadly Public Health disaster of International apprehension, with cases confirmed in several countries. This novel community health trouble is frightening the universe with clinical, psychological, emotional, collapse of health system and economical slowdown in each and every part of the world infecting nearly 200 countries. A highly vir...
Source: Monaldi Archives for Chest Disease - June 6, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Novel use of the endobronchial ultrasound through esophagus (EUS-B): Diagnosis of thyroid lesions.
We report the first case of colloid goiter diagnosed using EUS-B- FNA technique. A 77-year-old man presented with ophthalmic symptoms and an incidental finding of lung nodule on chest x-ray. The computed tomography of thorax revealed a left upper lobe nodule and an oval shaped left paratracheal lesion near left pole of thyroid gland. EUS-B- FNAC was performed which lead to the diagnosis of colloid goiter. PMID: 32447948 [PubMed - in process] (Source: Monaldi Archives for Chest Disease)
Source: Monaldi Archives for Chest Disease - May 27, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Extrapolation of mortality in COVID-19: Exploring the role of age, sex, co-morbidities and health-care related occupation.
Authors: Asfahan S, Deokar K, Dutt N, Niwas R, Jain P, Agarwal M Abstract We used a publicly available data of 44,672 patients reported by China's centre for disease control to study the role of age, sex, co-morbidities and health-care related occupation on COVID-19 mortality. The data is in the form of absolute numbers and proportions. Using the percentages, retrospective synthetic data of 100 survivors and 100 deaths were generated using random number libraries so that proportions of ages, genders, co-morbidities, and occupations were constant as in the original data. Logistic regression of the four predictor fac...
Source: Monaldi Archives for Chest Disease - May 27, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

COVID-19: Avoiding a second tragedy in a tuberculosis burdened country.
Authors: Yadav SR, Kumar R, Gupta N, Ish P, Chakrabarti S, Kumar A Abstract To the Editor Novel Coronavirus disease (COVID-19) was first notified in December 2019 from Wuhan, China. Now, it has spread rapidly and has been declared a pandemic affecting over 200 countries with widespread morbidity and mortality. It has been postulated that the most vulnerable population are the elderly, people living in crowded areas, children and immune-compromised individuals, such as people living with human immunodeficiency virus (HIV). The correlation of tuberculosis (TB), HIV and malnutrition are well documented and hence, peop...
Source: Monaldi Archives for Chest Disease - May 27, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Gender differences in patients with COVID-19: a narrative review.
Authors: Ambrosino I, Barbagelata E, Ortona E, Ruggieri A, Massiah G, Giannico OV, Politi C, Moretti AM Abstract In December 2019 a novel coronavirus emerged in Wuhan, China causing many cases of severe pneumonia. World Health Organization (WHO) named this disease Coronavirus Disease 2019 (COVID-19). The infection has rapidly spread across China to many other countries, and on March 12, 2020 the WHO declared pandemic outbreak of COVID-19. As of May 16, 2020, COVID-19 has been diagnosed in more than 4,490,000 patients, associated to 305,976 deaths worldwide; in Italy 224,760 COVID-19 cases have been reported with 31...
Source: Monaldi Archives for Chest Disease - May 27, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

ST-elevation during head up tilt test: a challenging case in syncope unit.
Authors: Carbone A, Avitabile V, Golino P, Nigro G, Russo V Abstract A 65-year-old woman, during an elective head up tilt test, after the sublingual nitrate administration, experienced electrocardiogram alteration with ST elevation in the inferior leads, that returned normal when the patient was laid supine after few minutes. Serial cardiac markers were not elevated and coronary angiography revealed normal epicardial coronary arteries. Paradoxical vasospastic response to nitrates in vasospastic angina patients represents a rare but very challenging condition and the best therapeutic approach in this subgroup of pat...
Source: Monaldi Archives for Chest Disease - May 23, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

A new insight on postural tachycardia syndrome in 102 adults with hypermobile Ehlers-Danlos Syndrome/hypermobility spectrum disorder.
This study confirms the high rate and heterogeneity of abnormal autonomic regulation in hEDS/HSD, and suggests the baroreflex sensitivity might distinguish comorbid POTS from other profiles in this subgroup of patients. Abnormal autonomic regulation is common in adults with hEDS/HSD and should be regularly assessed for tailoring the management approach. PMID: 32434316 [PubMed - in process] (Source: Monaldi Archives for Chest Disease)
Source: Monaldi Archives for Chest Disease - May 23, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Echocardiography of right ventricular-arterial coupling predicts survival of elderly patients with heart failure and reduced to mid-range ejection fraction.
Authors: Rosa GM, D'Agostino A, Giovinazzo S, La Malfa G, Fontanive P, Miccoli M, Dini FL Abstract Echocardiography of right ventricular (RV)-arterial coupling obtained by the estimation of the ratio of the longitudinal annular systolic excursion of the tricuspid annular plane and pulmonary artery systolic pressure (TAPSE/PASP) has been found to be a remarkable prognostic indicator in patients with HF. Our aim was to evaluate the impact of TAPSE, PASP and their ratio in the prognostic stratification of outpatients with HF aged ≥70 years and reduced to mid-range ejection fraction (EF). A complete echocardiographi...
Source: Monaldi Archives for Chest Disease - May 21, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

COVID-19 and coagulative axis: review of emerging aspects in a novel disease.
Authors: Boccia M, Aronne L, Celia B, Mazzeo G, Ceparano M, D'Agnano V, Parrella R, Valente T, Bianco A, Perrotta F Abstract Latest evidences from literature suggest that SARS-CoV-2 disease 2019 (COVID-19) is commonly complicated with coagulopathy and that disseminated intravascular coagulation is present in the majority of deceased patients. Particularly, conventional coagulation parameters appear to be significantly altered in patients with poor prognosis. A wide-ranging cross- talk between coagulative haemostasis and inflammation, as well as the activation of coagulation cascade during viral infections, are well...
Source: Monaldi Archives for Chest Disease - May 21, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

The role of echocardiography in SARS-CoV-2 pandemic: a compromise among appropriateness, safety and clinical impact.
Authors: Pacileo M, Giallauria F, Savarese C, Cirillo T, Crescibene F, Di Lorenzo A, Ferrillo M, Calabrese MG, Vigorito C, D'Andrea A Abstract SARS-CoV-2 infection, responsible for COVID-19, can determine cardiac events, which require a quick diagnosis and management, and should not be overlooked due to the presence of COVID-19 infection. In some cases, cardiovascular symptoms can also be the first and only manifestation of SARS-CoV-2 infection. In patients with COVID-19, the full cardiovascular disease diagnostic algorithm can be hindered by logistic restrain mainly derived from the difficulty of transporting pati...
Source: Monaldi Archives for Chest Disease - May 21, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

How the COVID-19 infection tsunami revolutionized the work of respiratory physiotherapists: an experience from Northern Italy.
Authors: Simonelli C, Paneroni M, Fokom AG, Saleri M, Speltoni I, Favero I, Garofali F, Scalvini S, Vitacca M Abstract Due to COVID-19 outbreak, to lighten the burden of acute and critical care hospitals, some respiratory rehabilitation departments have been used to host patients with COVID-19 in the post-acute phase. This new and unexpected situation required a change of roles and scheduling of the rehabilitation teams. In this manuscript we describe the unexpected and urgent organizational change of the Cardio-Pulmonary Rehabilitation (CPR) service during the COVID-19 emergency in a Northern Italian rehabilitatio...
Source: Monaldi Archives for Chest Disease - May 21, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Severity of COVID-19: The importance of being hypertensive.
Authors: Angeli F, Masnaghetti S, Visca D, Rossoni A, Taddeo S, Biagini F, Verdecchia P Abstract The novel respiratory Syndrome Coronavirus-2 (SARS-CoV-2) caused a cluster of pneumonia cases in China at the end of 2019. After few months, it led to a pandemic that has spread throughout most countries of the world (https://coronavirus.jhu.edu/map.html). PMID: 32432433 [PubMed - as supplied by publisher] (Source: Monaldi Archives for Chest Disease)
Source: Monaldi Archives for Chest Disease - May 21, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Postoperative outcomes following rehabilitation in patients with left ventricular assist devices.
Authors: Polastri M, Boschi S, Brillanti G, Martin-Suarez S, Masetti M, Potena L, Loforte A Abstract Postoperative rehabilitation is a cornerstone of the recovery pathway following left ventricular assist device implantation (LVAD), and patients are expected to conduct an autonomous life thanks to improved technology and increased knowledge of mechanical circulatory support. The primary purpose of the present study was to quantify clinical changes related to rehabilitation, in patients with LVAD: functional capacity, disability, and quality of life were identified as reliable outcomes to detect such changes. The cu...
Source: Monaldi Archives for Chest Disease - May 16, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Massive hemoptysis in a pregnant woman: the first rare presentation of mitral valve stenosis.
Authors: Hashemi F, Rezaitalab F, Jalalyazdi M Abstract Massive hemoptysis is one of the rare manifestations of mitral valve stenosis. Massive hemoptysis is considered as a potentially life threatening that frequently needs emergency procedures. A 43- year-old pregnant woman presented with coughing and massive hemoptysis. She was diagnosed severe rheumatic mitral stenosis. The patient underwent percutaneous transluminal mitral valvuloplasty (PTMC). Before ICU admission and hospitalization, she was healthy, without any past medical history and complaints. PMID: 32388966 [PubMed - in process] (Source: Monaldi Arc...
Source: Monaldi Archives for Chest Disease - May 13, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Cardiovascular system and COVID-19: perspectives from a developing country.
Authors: Kunal S, Gupta K, Sharma SM, Pathak V, Mittal S, Tarke C Abstract A novel coronavirus, SARS-CoV-2, thought to have originated from bats causes COVID-19 infection which was first reported from Wuhan, China in December 2019. This virus has a high infectivity rate and has impacted a significant chunk of the population worldwide. The spectrum of disease ranges from mild to severe with respiratory system being the most commonly affected. Cardiovascular system often gets involved in later stages of the disease with acute cardiac injury, heart failure and arrhythmias being the common complications. In addition, t...
Source: Monaldi Archives for Chest Disease - May 10, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

COVID-19 and clinical mimics. Correct diagnosis is the key to appropriate therapy.
Authors: Sahu KK, Mishra AK, Martin K, Chastain I Abstract As of 29 April 2020, across the globe, there are 3,216,353 confirmed Coronavirus disease 2019 (COVID-19 disease) with 227,894 deaths. The health care infrastructure of most of the countries is overwhelmed due to the gigantic upsurge of the new cases within a short time period. Most of the beds in the regular wards and critical care units are currently occupied by either people under investigation (PUI) or COVID-19 confirmed cases. We hereby discuss the challenges faced while approaching any case of shortness of breath, or other common upper respiratory symp...
Source: Monaldi Archives for Chest Disease - May 10, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Management of COVID-19: the risks associated with treatment are clear, but the benefits remain uncertain.
Authors: Zareifopoulos N, Lagadinou M, Karela A, Platanaki C, Karantzogiannis G, Velissaris D Abstract Even though the early reports from China provided advance warning of what was to come, the COVID-19 pandemic has spread throughout the world with devastating consequences. Emergency measures are being implemented to reduce the magnitude of the public health crisis, prevent healthcare facilities from becoming overwhelmed and reduce the death toll of the disease. Containment strategies to mitigate viral transmission and emergency measures to increase the capacity of each country to provide intensive care are at the ...
Source: Monaldi Archives for Chest Disease - May 7, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Proteomic characterization of idiopathic pulmonary fibrosis patients: stable versus acute exacerbation.
In this study proteomic comparative analysis of bronchoalveolar lavage (BAL) fluid samples was performed in stable IPF patients versus AEs IPF group to identify AE pathogenetic mechanisms and novel potential predictive biomarkers. A functional proteomic analysis of BAL fluid samples from stable and AE-IPF patients was conducted in a population of 27 IPF patients. Fifty-one differentially abundant spots were observed and identified by mass spectrometry. Enrichment analysis found proteins of interest involved in the regulation of macrophages and lipid metabolism receptors. In acute exacerbation IPF group, differentially abun...
Source: Monaldi Archives for Chest Disease - May 6, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Alternative sites of ventricular pacing: His bundle pacing.
Authors: Vetta F, Marinaccio L, Vetta G Abstract Since its introduction right ventricular apical (RVA) pacing has been the mainstay in cardiac pacing. However, in recent years there has been an upsurge of interest in permanent His bundle pacing (HBP), given the scientific evidence of the harmful role of dyssynchronous ventricular activation, induced by RVA pacing, in promoting the onset of heart failure and atrial fibrillation. After an intermediate period in which attention was focused on algorithms aimed at minimizing ventricular pacing, with partially inadequate and harmful results, scientific attention shifted ...
Source: Monaldi Archives for Chest Disease - May 1, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

The role of natriuretic peptide estimation in severe COVID-19.
Authors: Mahajan K, Negi P Abstract Since its inception in Wuhan in December 2019, Coronavirus disease 2019 (COVID-19) has shattered the economies and health-care infrastructures worldwide. Even the best of health-care systems (United States, Italy) have been overwhelmed and collapsed because of this unprecedented pandemic. India is preparing itself for the onslaught of Coronavirus. After recording its first case on January 30th, 2020, the rise was slow until the last week of March. However, since then, the number of cases has increased exponentially, and as on April 14th, 2020, there have been more than 10,000 cas...
Source: Monaldi Archives for Chest Disease - April 30, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Mucoepidermoid carcinoma of the bronchus: a rare early diagnosis.
We report a case of a young 21-year-old male medical student diagnosed and treated for the same prompted by a detailed respiratory examination. PMID: 32340430 [PubMed - in process] (Source: Monaldi Archives for Chest Disease)
Source: Monaldi Archives for Chest Disease - April 30, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Lambda sign on a gallium scan: not always sarcoidosis.
We describe a case of sputum smear-and culture-negative tuberculosis that was diagnosed with histological examination of a surgical lung biopsy, as other entities such as sarcoidosis could not be excluded after extended investigation. Even a typical lambda sign on gallium scintigraphy proved to be misleading. PMID: 32340431 [PubMed - in process] (Source: Monaldi Archives for Chest Disease)
Source: Monaldi Archives for Chest Disease - April 30, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Clinical and epidemiologic profile of the initial COVID-19 patients at a tertiary care centre in India.
The objective of this work is to report the initial experience with epidemiologic and clinical features, as well as with the management of COVID-19 patients in India. This is a descriptive case series of the first 21 COVID-19 infected patients confirmed with polymerase chain reaction (PCR) and admitted to a tertiary care centre in India from 01.02.2020 to 19.03.2020. Clinical, laboratory, and radiologic data were collected, including age, sex, nationality, travel history, symptoms, duration of stay, and comorbidities. The mean age of the population was 40.3 years with a male preponderance. Thirteen (62%) patients had recen...
Source: Monaldi Archives for Chest Disease - April 17, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Diagnostic yield of rapid on-site evaluation transbronchial needle aspiration versus conventional transbronchial needle aspiration: a single center experience.
Authors: Guarino C, Mollica M, Cesaro C, Costigliola A, Micheli MC, Corcione N, La Cerra G, Tranfa C, Cirillo S, Smeraglio R, Salvi R Abstract Trans-bronchial needle aspiration allows lymph node sampling in several thoracic conditions; the ability of Rapid On-Site Evaluation (ROSE) to predict the final diagnosis in this setting has not been well characterized. We performed a retrospective study to establish the utility of ROSE in the diagnosis of thoracic diseases with mediastinal lymph node involvement. We retrospectively reviewed 297 patients with hilar-mediastinal lymph node enlargement detected at CT scan from ...
Source: Monaldi Archives for Chest Disease - April 17, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

COVID-19 pandemic: what consequences for cardiac rehabilitation?
Authors: Vigorito C, Faggiano P, Mureddu GF Abstract The ongoing COVID-19 pandemic spreading all around the world has stressed over its capabilities and determined profound changes in the health systems in all countries and has caused hundreds of thousand deaths. Health professionals have been called to a tremendous effort to deal with this emergency, often contaminating or succumbing themselves to the disease. PMID: 32297490 [PubMed - in process] (Source: Monaldi Archives for Chest Disease)
Source: Monaldi Archives for Chest Disease - April 17, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

COVID-2019: update on epidemiology, disease spread and management.
Authors: Sahu KK, Mishra AK, Lal A Abstract With each passing day, more cases of Coronavirus disease (COVID-2019) are being detected and unfortunately the fear of novel corona virus 2019 (2019-nCoV) becoming a pandemic disease has come true. Constant efforts at individual, national, and international level are being made in order to understand the genomics, hosts, modes of transmission and epidemiological link of nCoV-2019. As of now, whole genome sequence of the newly discovered coronavirus has already been decoded. Genomic characterization nCoV-2019 have shown close homology with bat-derived severe acute respirat...
Source: Monaldi Archives for Chest Disease - April 17, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Pulmonary metastasis: very late relapse of testicular embryonal carcinoma.
We report a case of late recurrence of embryonic testicular carcinoma, after 26 years, with pulmonary metastases. Following evidence of increase of alpha-fetoprotein (AFP), the patient underwent a total body computed tomography scan that exhibited two pulmonary nodules, one in upper left lobe and other in left hilar region with multiple mediastinal and retrocrural lymph node enlargements All consolidations showed increased sugar uptake value at PET CT. Biopsies of lung consolidations confirmed diagnosis of recurrence of testicular carcinoma. PMID: 32268717 [PubMed - indexed for MEDLINE] (Source: Monaldi Archives for Chest Disease)
Source: Monaldi Archives for Chest Disease - April 11, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Anxiety and depression in adolescents with asthma and in their parents. Is an increased basal cholinergic tone a possible further reason to explain the negative impact on asthma control?
Authors: Liccardi G, Calzetta L, Milanese M, Bilò MB, Liccardi MV, Matera MG, Rogliani P Abstract To the Editor We read with interest the excellent article of Licari et al.  reporting that anxiety and depression are common in adolescents suffering from asthma as well as in their parents, mainly in mothers. The consequence of this relationship is that emotional disorders might negatively affect also the control of asthma. PMID: 32268718 [PubMed - indexed for MEDLINE] (Source: Monaldi Archives for Chest Disease)
Source: Monaldi Archives for Chest Disease - April 11, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Intubation and mechanical ventilation of patients with COVID-19: what should we tell them?
Discussion of prognosis is central to obtaining informed consent for intubation, but in the absence of definitive data it is not clear exactly what this discussion should entail. PMID: 32268719 [PubMed - indexed for MEDLINE] (Source: Monaldi Archives for Chest Disease)
Source: Monaldi Archives for Chest Disease - April 11, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Effects of stage-matched repeated individual behavioural counselling session (RIBCS) as an intervention for decreased and stopping smoking.
This study was conducted over a period of one year where all smokers presenting to a chest clinic in a tertiary centre were enrolled, each was classified on the basis of stage of readiness to change and underwent repeated counselling for a period of six months and each session was preceded and succeeded with filling of Fagerstorm test for nicotine dependence. Over the period of a year, 207 patients participated in this study, the mean age was 50.74±14.74 years; mean duration of tobacco use was 29.43±14.72 years; 64.3% were illiterate, 11.6% primary education, 14.1% were matric and while 10.1% were graduate. A...
Source: Monaldi Archives for Chest Disease - April 8, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Respiratory physiotherapy in patients with COVID-19 infection in acute setting: a Position Paper of the Italian Association of Respiratory Physiotherapists (ARIR).
Authors: Lazzeri M, Lanza A, Bellini R, Bellofiore A, Cecchetto S, Colombo A, D'Abrosca F, Del Monaco C, Gaudiello G, Paneroni M, Privitera E, Retucci M, Rossi V, Santambrogio M, Sommariva M, Frigerio P Abstract Respiratory physiotherapy in patients with COVID-19 infection in acute setting: a Position Paper of the Italian Association of Respiratory Physiotherapists (ARIR) On February 2020, Italy, especially the northern regions, was hit by an epidemic of the new SARS-Cov-2 coronavirus that spread from China between December 2019 and January 2020. The entire healthcare system had to respond promptly in a very short ...
Source: Monaldi Archives for Chest Disease - April 4, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

The brain-heart connection: a multiple sclerosis relapse presenting as Takotsubo Syndrome. A case report and literature review.
Authors: Dell'Aquila A, Sciatti E, Vizzardi E, Metra M Abstract We hereby report a puzzling case of multiple sclerosis (MS) relapse presenting as Takotsubo syndrome (TTS). Female, 42-years old, who presented herself to the Emergency Room of University Hospital "ASST Spedali Civili" of Brescia, Italy, for a severe headache and a non-ST-segment elevation acute coronary syndrome. Coronary angiogram showed no signs of coronary atherosclerosis. Upon further neurological evaluation, a diagnosis of MS relapse, related to TTS, was made, and treatment was started accordingly. The patient was discharged after 12 da...
Source: Monaldi Archives for Chest Disease - April 4, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Factors contributing to drug-resistant tuberculosis treatment outcome in five countries in the Eastern Europe and Central Asia region.
Discussions (FGDs) with DR-TB patients. The desk review of 38 reports identified as the main challenges to address DR-TB financial and/or management issues and adverse events of the medicines. The most common recommendations related to treatment outcome focussed on general programme management, treatment regimen composition, clinical management and social support for the patients. In all the five countries the NTPs still have a vertical structure. Some integration into the primary health care system (PHC) already exists but further involvement of PHC facilities is feasible and recommended. Interviews with stakeholders indi...
Source: Monaldi Archives for Chest Disease - April 3, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Emerging prophylaxis strategies against COVID-19.
Authors: Agrawal S, Goel AD, Gupta N Abstract The Novel corona virus 2019 which started as an outbreak in China in December 2019 has rapidly spread all over the world, such that on 11th March 2020 WHO declared this disease as pandemic. The emergency that the world faces today demands that we develop urgent and effective measures to protect people at high risk of transmission. WHO has accelerated research in diagnostics, vaccines and therapeutics for this novel coronavirus. PMID: 32231348 [PubMed - indexed for MEDLINE] (Source: Monaldi Archives for Chest Disease)
Source: Monaldi Archives for Chest Disease - April 3, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Chloroquine in COVID-19: the evidence.
Authors: Gupta N, Agrawal S, Ish P Abstract To the Editor The Coronavirus disease 2019 (COVID-19) has been declared as a pandemic by World Health Organisation (WHO). The global mortality has increased, especially in countries like Italy and Iran. With the increasing morbidity and mortality, search for a cure has been the global demand. PMID: 32231349 [PubMed - indexed for MEDLINE] (Source: Monaldi Archives for Chest Disease)
Source: Monaldi Archives for Chest Disease - April 3, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Difference in prevalence of exertional oscillatory ventilation between healthy subjects and patients with cardiovascular disease.
Authors: Corrà U, Piepoli M, Giordano A Abstract Exercise oscillatory ventilation (EOV) is an ominous sign in heart failure due to reduced left ventricular ejection fraction (HFrEF) whatever it is represented. But EOV is detected also in normal healthy individuals and in other cardiovascular disease (CVD) patients, however, its prevalence in these is not completed clear. The aim was to describe the occurrence of EOV in healthy subjects and the overall population all CVD patients who performing symptom limited cardiopulmonary exercise testing (CPET). Healthy subjects were divided in athletes and normal subjec...
Source: Monaldi Archives for Chest Disease - April 1, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

COVID-19 in intensive care. Some necessary steps for health care workers.
Authors: Malhotra N, Gupta N, Ish S, Ish P Abstract Due to the nature of their profession, health care personnel (HCP) have always been easy targets for transmission of communicable diseases like COVID-19. Shielding HCPs is of consequential significance in ensuring continued health care for the whole population in addition to reducing further spread. Close contact, repeated contact and prolonged contact are unavoidable in the intensive care (IC) environment. It is not uncommon for IC-HCPs to get carried away during an emergent situation, such as that posed by a suddenly deteriorating patient, and forgo the protecti...
Source: Monaldi Archives for Chest Disease - March 28, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Edoxaban in elderly patient with morbid obesity and atrial fibrillation: the role of plasma levels evaluation for selecting the appropriate dose.
We present the case of a 80-year-old man with atrial fibrillation, morbid obesity (weight 123 kg, height 167 cm, BMI 44.1), high clearance of creatinine and pharmacological polytherapy, in which the serial determinations of edoxaban plasma levels help us to choose the appropriate dose. PMID: 32204583 [PubMed - in process] (Source: Monaldi Archives for Chest Disease)
Source: Monaldi Archives for Chest Disease - March 25, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research

Therapeutic strategy for tracheal chondrosarcoma: report of two cases.
We report two cases of tracheal chondrosarcoma describing the role of surgical and conservative treatment. Endoscopic treatment with rigid bronchoscopy was performed in both patients to restore airway patency and obtain histological specimens for diagnosis. One of the patients subsequently underwent successful tracheal resection and reconstruction. The other patient, who had a contraindication to surgical treatment due to associated diseases underwent iterative endoscopic LASER treatment and is alive three years after the first diagnosis. Surgical treatment remains the treatment of choice of tracheal chondrosarcoma. When s...
Source: Monaldi Archives for Chest Disease - March 14, 2020 Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research