PDL1 and molecular biomarkers expression in non-small cell lung cancer in Tunisian patients
Monaldi Arch Chest Dis. 2023 Nov 3. doi: 10.4081/monaldi.2023.2778. Online ahead of print.ABSTRACTIn cancer treatment, programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) inhibitors are thriving. Activated T lymphocytes expressed PD-1, it works with its ligand PD-L1 to limit T lymphocyte activation and prevent autoimmune disease. The expression of molecular biomarkers and PD-L1 in lung cancer determines the appropriate treatment strategy for patients with lung cancer. The purpose of this study was to look at the prevalence of molecular biomarkers and PD-L1 expression in a large group of Tunisian patients with a...
Source: Monaldi Archives for Chest Disease - November 6, 2023 Category: Respiratory Medicine Authors: Yoldez Houcine Chirine Moussa Ahmed Ben Abdelaziz Aida Ayadi Source Type: research

Comments on "Comparison of immediate withdrawal and stepwise reduction in duration of non-invasive ventilation in chronic obstructive pulmonary disease patients presenting with acute hypercapnic respiratory failure"
Monaldi Arch Chest Dis. 2023 Nov 6. doi: 10.4081/monaldi.2023.2828. Online ahead of print.ABSTRACTDear Editor, The recent study published by Purohit et al. provides new evidence on the safety of immediate withdrawal of non-invasive ventilation (NIV) in chronic obstructive pulmonary disease (COPD) patients admitted with acute hypercapnic respiratory failure (AHRF) after recovery...PMID:37930650 | DOI:10.4081/monaldi.2023.2828 (Source: Monaldi Archives for Chest Disease)
Source: Monaldi Archives for Chest Disease - November 6, 2023 Category: Respiratory Medicine Authors: Vidushi Rathi Source Type: research

Serial evaluation of antibody titres in patients recovered from COVID-19 and their correlation with disease severity
Monaldi Arch Chest Dis. 2023 Nov 3. doi: 10.4081/monaldi.2023.2677. Online ahead of print.ABSTRACTOn March 11, 2020, the World Health Organization (WHO) declared COVID-19 a pandemic. According to the findings of various studies conducted around the world, the serological response varies greatly among different populations, with the determinants of variable response still unknown, including the role of disease severity, which is thought to have a definite correlation. The purpose of this study was to assess serial SARS-CoV-2 IgG antibody response in COVID-19 patients and correlate it with disease severity. It was a longitud...
Source: Monaldi Archives for Chest Disease - November 6, 2023 Category: Respiratory Medicine Authors: Amrutha S Komaldeep Kaur Deepak Aggarwal Mandeep Kaur Sodhi Shivani Jaswal Varinder Saini Source Type: research

Diabetes mellitus in acute exacerbation of chronic obstructive pulmonary disease - the tip of the iceberg
Monaldi Arch Chest Dis. 2023 Nov 6. doi: 10.4081/monaldi.2023.2776. Online ahead of print.ABSTRACTCOPD is a chronic respiratory disease characterized by systemic inflammation caused primarily by tobacco use, and it is associated with an increased susceptibility to respiratory infections, both viral and bacterial, which are responsible for acute COPD exacerbations (AECOPD). Diabetes mellitus is one of the most common co-morbidities in COPD patients. In our study, we attempted to detect previously undiagnosed diabetes in AECOPD patients who presented to our Institute. The study included 100 patients who had been diagnosed wi...
Source: Monaldi Archives for Chest Disease - November 6, 2023 Category: Respiratory Medicine Authors: Devika Tayal Prerna Jain Mamta Bhardwaj Amit Sharma Source Type: research

TakoTsubo secondary to acute kidney disease
We report the case of a 62-year-old man who was admitted to the Cardiac Department for TakoTsubo and ACC by torsades de point, secondary to acute kidney disease. We decide to discharge with a portable defibrillator. One month after cardiac magnetic resonance showed a complete recovery of left ventricular function.PMID:37930655 | DOI:10.4081/monaldi.2023.2816 (Source: Monaldi Archives for Chest Disease)
Source: Monaldi Archives for Chest Disease - November 6, 2023 Category: Respiratory Medicine Authors: Angelica Cersosimo Gianmarco Arabia Enrico Vizzardi Source Type: research

SARS-CoV-2 pneumonia and Eisenmenger's Syndrome: doubling the challenge
Monaldi Arch Chest Dis. 2023 Nov 6. doi: 10.4081/monaldi.2023.2741. Online ahead of print.ABSTRACTEisenmenger's syndrome (ES) is the most severe phenotype of pulmonary arterial hypertension (PAH) secondary to congenital heart disease. In these cases, a significant systemic-to-pulmonary (left-to-right) shunting triggers the development of pulmonary vascular disease (PVD) and pulmonary hypertension. In cases of acute hypoxemic respiratory failure in patients with ES, high flow nasal cannula (HFNC) oxygen therapy should be considered as a first-line approach in order to avoid pulmonary complications and right ventricular over...
Source: Monaldi Archives for Chest Disease - November 6, 2023 Category: Respiratory Medicine Authors: Paola Pierucci Lucrezia De Michele Maria Luisa De Candia Federica Barratta Cesare Gregoretti Giovanna Elisiana Carpagnano Giovanni Misseri Source Type: research

COVID myocarditis: a review of the literature
Monaldi Arch Chest Dis. 2023 Nov 3. doi: 10.4081/monaldi.2023.2784. Online ahead of print.ABSTRACTMyocarditis is a potentially fatal complication of coronavirus disease 2019 (COVID-19), which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. COVID-19 myocarditis appears to have distinct inflammatory characteristics that distinguish it from other viral etiologies. COVID-19 myocarditis can present with symptoms ranging from dyspnea and chest pain to acute heart failure and death. It is critical to detect any cases of myocarditis, especially fulminant myocarditis, which can be characterized ...
Source: Monaldi Archives for Chest Disease - November 6, 2023 Category: Respiratory Medicine Authors: Angelica Cersosimo Mattia Di Pasquale Gianmarco Arabia Marco Metra Enrico Vizzardi Source Type: research

Impact of percutaneous coronary intervention on renal function in patients with coronary heart disease
We examined data from 1572 CHD patients who had coronary angiography (CAG) or PCI in this retrospective cohort study. Patients receiving elective PCI (n=1240) and CAG (n=332) between January 2013 and December 2018 were included. Pre-PCI and procedural variables associated with post-PCI eGFR, change in renal function after post-PCI follow-up, and post-PCI eGFR association with major adverse cardiovascular events were investigated. Following the procedure, 88.7 percent of PCI group patients had unchanged or improved renal function. The treatment of PCI was found to independently correlate with IRF following coronary angiogra...
Source: Monaldi Archives for Chest Disease - November 6, 2023 Category: Respiratory Medicine Authors: Bing Ji Tongqing Yao Jing Tong Zi Ye Fan Ping Fei Chen Xue-Bo Liu Source Type: research

PDL1 and molecular biomarkers expression in non-small cell lung cancer in Tunisian patients
Monaldi Arch Chest Dis. 2023 Nov 3. doi: 10.4081/monaldi.2023.2778. Online ahead of print.ABSTRACTIn cancer treatment, programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) inhibitors are thriving. Activated T lymphocytes expressed PD-1, it works with its ligand PD-L1 to limit T lymphocyte activation and prevent autoimmune disease. The expression of molecular biomarkers and PD-L1 in lung cancer determines the appropriate treatment strategy for patients with lung cancer. The purpose of this study was to look at the prevalence of molecular biomarkers and PD-L1 expression in a large group of Tunisian patients with a...
Source: Monaldi Archives for Chest Disease - November 6, 2023 Category: Respiratory Medicine Authors: Yoldez Houcine Chirine Moussa Ahmed Ben Abdelaziz Aida Ayadi Source Type: research

Comments on "Comparison of immediate withdrawal and stepwise reduction in duration of non-invasive ventilation in chronic obstructive pulmonary disease patients presenting with acute hypercapnic respiratory failure"
Monaldi Arch Chest Dis. 2023 Nov 6. doi: 10.4081/monaldi.2023.2828. Online ahead of print.ABSTRACTDear Editor, The recent study published by Purohit et al. provides new evidence on the safety of immediate withdrawal of non-invasive ventilation (NIV) in chronic obstructive pulmonary disease (COPD) patients admitted with acute hypercapnic respiratory failure (AHRF) after recovery...PMID:37930650 | DOI:10.4081/monaldi.2023.2828 (Source: Monaldi Archives for Chest Disease)
Source: Monaldi Archives for Chest Disease - November 6, 2023 Category: Respiratory Medicine Authors: Vidushi Rathi Source Type: research

Serial evaluation of antibody titres in patients recovered from COVID-19 and their correlation with disease severity
Monaldi Arch Chest Dis. 2023 Nov 3. doi: 10.4081/monaldi.2023.2677. Online ahead of print.ABSTRACTOn March 11, 2020, the World Health Organization (WHO) declared COVID-19 a pandemic. According to the findings of various studies conducted around the world, the serological response varies greatly among different populations, with the determinants of variable response still unknown, including the role of disease severity, which is thought to have a definite correlation. The purpose of this study was to assess serial SARS-CoV-2 IgG antibody response in COVID-19 patients and correlate it with disease severity. It was a longitud...
Source: Monaldi Archives for Chest Disease - November 6, 2023 Category: Respiratory Medicine Authors: Amrutha S Komaldeep Kaur Deepak Aggarwal Mandeep Kaur Sodhi Shivani Jaswal Varinder Saini Source Type: research

Diabetes mellitus in acute exacerbation of chronic obstructive pulmonary disease - the tip of the iceberg
Monaldi Arch Chest Dis. 2023 Nov 6. doi: 10.4081/monaldi.2023.2776. Online ahead of print.ABSTRACTCOPD is a chronic respiratory disease characterized by systemic inflammation caused primarily by tobacco use, and it is associated with an increased susceptibility to respiratory infections, both viral and bacterial, which are responsible for acute COPD exacerbations (AECOPD). Diabetes mellitus is one of the most common co-morbidities in COPD patients. In our study, we attempted to detect previously undiagnosed diabetes in AECOPD patients who presented to our Institute. The study included 100 patients who had been diagnosed wi...
Source: Monaldi Archives for Chest Disease - November 6, 2023 Category: Respiratory Medicine Authors: Devika Tayal Prerna Jain Mamta Bhardwaj Amit Sharma Source Type: research

TakoTsubo secondary to acute kidney disease
We report the case of a 62-year-old man who was admitted to the Cardiac Department for TakoTsubo and ACC by torsades de point, secondary to acute kidney disease. We decide to discharge with a portable defibrillator. One month after cardiac magnetic resonance showed a complete recovery of left ventricular function.PMID:37930655 | DOI:10.4081/monaldi.2023.2816 (Source: Monaldi Archives for Chest Disease)
Source: Monaldi Archives for Chest Disease - November 6, 2023 Category: Respiratory Medicine Authors: Angelica Cersosimo Gianmarco Arabia Enrico Vizzardi Source Type: research

SARS-CoV-2 pneumonia and Eisenmenger's Syndrome: doubling the challenge
Monaldi Arch Chest Dis. 2023 Nov 6. doi: 10.4081/monaldi.2023.2741. Online ahead of print.ABSTRACTEisenmenger's syndrome (ES) is the most severe phenotype of pulmonary arterial hypertension (PAH) secondary to congenital heart disease. In these cases, a significant systemic-to-pulmonary (left-to-right) shunting triggers the development of pulmonary vascular disease (PVD) and pulmonary hypertension. In cases of acute hypoxemic respiratory failure in patients with ES, high flow nasal cannula (HFNC) oxygen therapy should be considered as a first-line approach in order to avoid pulmonary complications and right ventricular over...
Source: Monaldi Archives for Chest Disease - November 6, 2023 Category: Respiratory Medicine Authors: Paola Pierucci Lucrezia De Michele Maria Luisa De Candia Federica Barratta Cesare Gregoretti Giovanna Elisiana Carpagnano Giovanni Misseri Source Type: research

COVID myocarditis: a review of the literature
Monaldi Arch Chest Dis. 2023 Nov 3. doi: 10.4081/monaldi.2023.2784. Online ahead of print.ABSTRACTMyocarditis is a potentially fatal complication of coronavirus disease 2019 (COVID-19), which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. COVID-19 myocarditis appears to have distinct inflammatory characteristics that distinguish it from other viral etiologies. COVID-19 myocarditis can present with symptoms ranging from dyspnea and chest pain to acute heart failure and death. It is critical to detect any cases of myocarditis, especially fulminant myocarditis, which can be characterized ...
Source: Monaldi Archives for Chest Disease - November 6, 2023 Category: Respiratory Medicine Authors: Angelica Cersosimo Mattia Di Pasquale Gianmarco Arabia Marco Metra Enrico Vizzardi Source Type: research