Review - Combinatory approaches targeting cognitive impairments and memory enhancement
The objective of this paper is to look at how natural medicines can improve cognition and memory when used with sildenafil, a popular erectile dysfunction medicine that also has nootropic properties. Newer treatment strategies to treat the early stages of these diseases need to be developed. Multiple factors lead to complex pathophysiological conditions, which are responsible for various long-term complications. In this review a combination of treatments targeting these pathologies are discussed. These combinations may help manage early and later phases of cognitive impairments. The purpose of this article is to discuss a ...
Source: Current Drug Targets - September 29, 2022 Category: Drugs & Pharmacology Authors: Varun Santosh Gupta Pravin Popatrao Kale Source Type: research

Epileptic Targets And Drugs: A Mini-Review
CONCLUSION: Quantitative Structure-Activity Relationship (QSAR) and computer aided drug design (CADD) in predicting of possible pharmacological activities of these targets.PMID:36173074 | DOI:10.2174/1389450123666220927103715 (Source: Current Drug Targets)
Source: Current Drug Targets - September 29, 2022 Category: Drugs & Pharmacology Authors: Teresa Carolliny Moreira Lustoza Rodrigues J éssica Paiva de Moura Aline Matilde Ferreira Dos Santos Alex France M Monteiroa Simone Mendes Lopes Marcus T Scotti Luciana Scotti Source Type: research

Review - Combinatory approaches targeting cognitive impairments and memory enhancement
The objective of this paper is to look at how natural medicines can improve cognition and memory when used with sildenafil, a popular erectile dysfunction medicine that also has nootropic properties. Newer treatment strategies to treat the early stages of these diseases need to be developed. Multiple factors lead to complex pathophysiological conditions, which are responsible for various long-term complications. In this review a combination of treatments targeting these pathologies are discussed. These combinations may help manage early and later phases of cognitive impairments. The purpose of this article is to discuss a ...
Source: Current Drug Targets - September 29, 2022 Category: Drugs & Pharmacology Authors: Varun Santosh Gupta Pravin Popatrao Kale Source Type: research

Epileptic Targets And Drugs: A Mini-Review
CONCLUSION: Quantitative Structure-Activity Relationship (QSAR) and computer aided drug design (CADD) in predicting of possible pharmacological activities of these targets.PMID:36173074 | DOI:10.2174/1389450123666220927103715 (Source: Current Drug Targets)
Source: Current Drug Targets - September 29, 2022 Category: Drugs & Pharmacology Authors: Teresa Carolliny Moreira Lustoza Rodrigues J éssica Paiva de Moura Aline Matilde Ferreira Dos Santos Alex France M Monteiroa Simone Mendes Lopes Marcus T Scotti Luciana Scotti Source Type: research

Review - Combinatory approaches targeting cognitive impairments and memory enhancement
The objective of this paper is to look at how natural medicines can improve cognition and memory when used with sildenafil, a popular erectile dysfunction medicine that also has nootropic properties. Newer treatment strategies to treat the early stages of these diseases need to be developed. Multiple factors lead to complex pathophysiological conditions, which are responsible for various long-term complications. In this review a combination of treatments targeting these pathologies are discussed. These combinations may help manage early and later phases of cognitive impairments. The purpose of this article is to discuss a ...
Source: Current Drug Targets - September 29, 2022 Category: Drugs & Pharmacology Authors: Varun Santosh Gupta Pravin Popatrao Kale Source Type: research

Epileptic Targets And Drugs: A Mini-Review
CONCLUSION: Quantitative Structure-Activity Relationship (QSAR) and computer aided drug design (CADD) in predicting of possible pharmacological activities of these targets.PMID:36173074 | DOI:10.2174/1389450123666220927103715 (Source: Current Drug Targets)
Source: Current Drug Targets - September 29, 2022 Category: Drugs & Pharmacology Authors: Teresa Carolliny Moreira Lustoza Rodrigues J éssica Paiva de Moura Aline Matilde Ferreira Dos Santos Alex France M Monteiroa Simone Mendes Lopes Marcus T Scotti Luciana Scotti Source Type: research

Study on Multi-target Synergistic Treatment of Alzheimer's Disease Based on Metal Chelators
Curr Drug Targets. 2022 Sep 26. doi: 10.2174/1389450123666220926143920. Online ahead of print.ABSTRACTAlzheimer's disease (AD) has become the fourth leading cause of death in the world. Due to its complex pathogenesis, there is still a lack of effective drug treatments. Studies have found that the metal dyshomeostasis is closely related to other pathogeneses of AD such as oxidative stress, β-amyloid protein deposits etc. Therefore, it becomes an important target to find the appropriate metal chelating agents to regulate the metal homeostasis. At the same time, because of the complex pathogenesis, single target drugs canno...
Source: Current Drug Targets - September 27, 2022 Category: Drugs & Pharmacology Authors: Aihong Yang Jianhua Wu Yuhong Chen Rui Shen Xiaodi Kou Source Type: research

Tissue factor and COVID-19: an update
Curr Drug Targets. 2022 Sep 26. doi: 10.2174/1389450123666220926144432. Online ahead of print.ABSTRACTThe coronavirus 2019 [COVID-19] pandemic is caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] virus. Infection with SARS-CoV-2 is associated with an acute respiratory distress syndrome, thrombosis and a high rate of mortality. Thrombotic events increase with severity. Tissue factor [TF] expression is increased during viral and bacterial infections. This review summarizes studies that have examined TF expression in response to SARS-CoV-2 infection. SARS-CoV-2 virus and its proteins upregulate TF mRNA, p...
Source: Current Drug Targets - September 27, 2022 Category: Drugs & Pharmacology Authors: Ana Teresa Azevedo Sachettor Nigel Mackman Source Type: research

Study on Multi-target Synergistic Treatment of Alzheimer's Disease Based on Metal Chelators
Curr Drug Targets. 2022 Sep 26. doi: 10.2174/1389450123666220926143920. Online ahead of print.ABSTRACTAlzheimer's disease (AD) has become the fourth leading cause of death in the world. Due to its complex pathogenesis, there is still a lack of effective drug treatments. Studies have found that the metal dyshomeostasis is closely related to other pathogeneses of AD such as oxidative stress, β-amyloid protein deposits etc. Therefore, it becomes an important target to find the appropriate metal chelating agents to regulate the metal homeostasis. At the same time, because of the complex pathogenesis, single target drugs canno...
Source: Current Drug Targets - September 27, 2022 Category: Drugs & Pharmacology Authors: Aihong Yang Jianhua Wu Yuhong Chen Rui Shen Xiaodi Kou Source Type: research

Tissue factor and COVID-19: an update
Curr Drug Targets. 2022 Sep 26. doi: 10.2174/1389450123666220926144432. Online ahead of print.ABSTRACTThe coronavirus 2019 [COVID-19] pandemic is caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] virus. Infection with SARS-CoV-2 is associated with an acute respiratory distress syndrome, thrombosis and a high rate of mortality. Thrombotic events increase with severity. Tissue factor [TF] expression is increased during viral and bacterial infections. This review summarizes studies that have examined TF expression in response to SARS-CoV-2 infection. SARS-CoV-2 virus and its proteins upregulate TF mRNA, p...
Source: Current Drug Targets - September 27, 2022 Category: Drugs & Pharmacology Authors: Ana Teresa Azevedo Sachettor Nigel Mackman Source Type: research

Correlation of stress and depression with cancer initiation and progression; a mechanistic review
In conclusion, the importance of preventive interventions to monitor patients' mental health during cancer treatment is very significant and should not be underestimated. In other words, the initial interventions can improve depressive symptoms and increase cancer survival. On the other hand, by identifying key biomarkers of depression, physicians can identify cancer patients who are at risk for depression or those who may not respond to routine treatments. Understanding how the cancer environment can cause pathophysiological phenomena helps develop new anti-depressant therapies and identify cancer patients that may be pre...
Source: Current Drug Targets - September 26, 2022 Category: Drugs & Pharmacology Authors: Ailar Nakhlband Raheleh Farahzadi Nazli Saeedi Habibeh Barzegar Soheila Montazersaheb Saiedeh Razi Soofiyani Source Type: research

Gastrointestinal system, COVID-19 and potential mechanisms associated with coagulopathy
Curr Drug Targets. 2022 Sep 22. doi: 10.2174/1389450123666220922095913. Online ahead of print.ABSTRACTSARS-CoV-2 is a novel coronavirus expanded worldwide, generating a pandemic of acute respiratory syndrome called "coronavirus disease 2019" (COVID-19), which resulted in a global health crisis. The spectrum of COVID-19 manifestations ranges from none or mild symptoms to severe respiratory failure associated with systemic manifestations, mostly gastrointestinal symptoms. Hypercoagulability is an important feature of COVID-19 disease, which can potentially influence patients' prognosis. Therefore, gastroenterologists should ...
Source: Current Drug Targets - September 26, 2022 Category: Drugs & Pharmacology Authors: Federica Furfaro Roberto Gabbiadini Ferdinando D'Amico Alessandra Zilli Arianna Dal Buono Mariangela Allocca Gionata Fiorino Silvio Danese Source Type: research

Correlation of stress and depression with cancer initiation and progression; a mechanistic review
In conclusion, the importance of preventive interventions to monitor patients' mental health during cancer treatment is very significant and should not be underestimated. In other words, the initial interventions can improve depressive symptoms and increase cancer survival. On the other hand, by identifying key biomarkers of depression, physicians can identify cancer patients who are at risk for depression or those who may not respond to routine treatments. Understanding how the cancer environment can cause pathophysiological phenomena helps develop new anti-depressant therapies and identify cancer patients that may be pre...
Source: Current Drug Targets - September 26, 2022 Category: Drugs & Pharmacology Authors: Ailar Nakhlband Raheleh Farahzadi Nazli Saeedi Habibeh Barzegar Soheila Montazersaheb Saiedeh Razi Soofiyani Source Type: research

Gastrointestinal system, COVID-19 and potential mechanisms associated with coagulopathy
Curr Drug Targets. 2022 Sep 22. doi: 10.2174/1389450123666220922095913. Online ahead of print.ABSTRACTSARS-CoV-2 is a novel coronavirus expanded worldwide, generating a pandemic of acute respiratory syndrome called "coronavirus disease 2019" (COVID-19), which resulted in a global health crisis. The spectrum of COVID-19 manifestations ranges from none or mild symptoms to severe respiratory failure associated with systemic manifestations, mostly gastrointestinal symptoms. Hypercoagulability is an important feature of COVID-19 disease, which can potentially influence patients' prognosis. Therefore, gastroenterologists should ...
Source: Current Drug Targets - September 26, 2022 Category: Drugs & Pharmacology Authors: Federica Furfaro Roberto Gabbiadini Ferdinando D'Amico Alessandra Zilli Arianna Dal Buono Mariangela Allocca Gionata Fiorino Silvio Danese Source Type: research

Targeted Covalent Inhibition: A Prospective Way to Develop Novel HSP90 C-terminal Inhibitor
Curr Drug Targets. 2022 Sep 20. doi: 10.2174/1389450123666220920111841. Online ahead of print.NO ABSTRACTPMID:36125840 | DOI:10.2174/1389450123666220920111841 (Source: Current Drug Targets)
Source: Current Drug Targets - September 20, 2022 Category: Drugs & Pharmacology Authors: Yajun Liu Yajing Li Source Type: research