A Revisit to Etiopathogenesis and Therapeutic Strategies in Alzheimer's Disease
Curr Drug Targets. 2021 Nov 18. doi: 10.2174/1389450122666211118125233. Online ahead of print.ABSTRACTDementia is a cluster of brain abnormalities that trigger progressive memory deficits and other cognitive abilities such as skills, language, or executive function. Alzheimer's disease (AD) is the foremost type of age-associated dementia that involves progressive neurodegeneration accompanied by profound cognitive deficits in advanced stages that severely hamper social or occupational abilities with or without the involvement of any other psychiatric condition. The last two decades witnessed a sharp increase (~123%) in mor...
Source: Current Drug Targets - November 18, 2021 Category: Drugs & Pharmacology Authors: Manish Kumar Nitin Bansal Source Type: research

A Revisit to Etiopathogenesis and Therapeutic Strategies in Alzheimer's Disease
Curr Drug Targets. 2021 Nov 18. doi: 10.2174/1389450122666211118125233. Online ahead of print.ABSTRACTDementia is a cluster of brain abnormalities that trigger progressive memory deficits and other cognitive abilities such as skills, language, or executive function. Alzheimer's disease (AD) is the foremost type of age-associated dementia that involves progressive neurodegeneration accompanied by profound cognitive deficits in advanced stages that severely hamper social or occupational abilities with or without the involvement of any other psychiatric condition. The last two decades witnessed a sharp increase (~123%) in mor...
Source: Current Drug Targets - November 18, 2021 Category: Drugs & Pharmacology Authors: Manish Kumar Nitin Bansal Source Type: research

A Revisit to Etiopathogenesis and Therapeutic Strategies in Alzheimer's Disease
Curr Drug Targets. 2021 Nov 18. doi: 10.2174/1389450122666211118125233. Online ahead of print.ABSTRACTDementia is a cluster of brain abnormalities that trigger progressive memory deficits and other cognitive abilities such as skills, language, or executive function. Alzheimer's disease (AD) is the foremost type of age-associated dementia that involves progressive neurodegeneration accompanied by profound cognitive deficits in advanced stages that severely hamper social or occupational abilities with or without the involvement of any other psychiatric condition. The last two decades witnessed a sharp increase (~123%) in mor...
Source: Current Drug Targets - November 18, 2021 Category: Drugs & Pharmacology Authors: Manish Kumar Nitin Bansal Source Type: research

A Revisit to Etiopathogenesis and Therapeutic Strategies in Alzheimer's Disease
Curr Drug Targets. 2021 Nov 18. doi: 10.2174/1389450122666211118125233. Online ahead of print.ABSTRACTDementia is a cluster of brain abnormalities that trigger progressive memory deficits and other cognitive abilities such as skills, language, or executive function. Alzheimer's disease (AD) is the foremost type of age-associated dementia that involves progressive neurodegeneration accompanied by profound cognitive deficits in advanced stages that severely hamper social or occupational abilities with or without the involvement of any other psychiatric condition. The last two decades witnessed a sharp increase (~123%) in mor...
Source: Current Drug Targets - November 18, 2021 Category: Drugs & Pharmacology Authors: Manish Kumar Nitin Bansal Source Type: research

A Revisit to Etiopathogenesis and Therapeutic Strategies in Alzheimer's Disease
Curr Drug Targets. 2021 Nov 18. doi: 10.2174/1389450122666211118125233. Online ahead of print.ABSTRACTDementia is a cluster of brain abnormalities that trigger progressive memory deficits and other cognitive abilities such as skills, language, or executive function. Alzheimer's disease (AD) is the foremost type of age-associated dementia that involves progressive neurodegeneration accompanied by profound cognitive deficits in advanced stages that severely hamper social or occupational abilities with or without the involvement of any other psychiatric condition. The last two decades witnessed a sharp increase (~123%) in mor...
Source: Current Drug Targets - November 18, 2021 Category: Drugs & Pharmacology Authors: Manish Kumar Nitin Bansal Source Type: research

A Revisit to Etiopathogenesis and Therapeutic Strategies in Alzheimer's Disease
Curr Drug Targets. 2021 Nov 18. doi: 10.2174/1389450122666211118125233. Online ahead of print.ABSTRACTDementia is a cluster of brain abnormalities that trigger progressive memory deficits and other cognitive abilities such as skills, language, or executive function. Alzheimer's disease (AD) is the foremost type of age-associated dementia that involves progressive neurodegeneration accompanied by profound cognitive deficits in advanced stages that severely hamper social or occupational abilities with or without the involvement of any other psychiatric condition. The last two decades witnessed a sharp increase (~123%) in mor...
Source: Current Drug Targets - November 18, 2021 Category: Drugs & Pharmacology Authors: Manish Kumar Nitin Bansal Source Type: research

A Revisit to Etiopathogenesis and Therapeutic Strategies in Alzheimer's Disease
Curr Drug Targets. 2021 Nov 18. doi: 10.2174/1389450122666211118125233. Online ahead of print.ABSTRACTDementia is a cluster of brain abnormalities that trigger progressive memory deficits and other cognitive abilities such as skills, language, or executive function. Alzheimer's disease (AD) is the foremost type of age-associated dementia that involves progressive neurodegeneration accompanied by profound cognitive deficits in advanced stages that severely hamper social or occupational abilities with or without the involvement of any other psychiatric condition. The last two decades witnessed a sharp increase (~123%) in mor...
Source: Current Drug Targets - November 18, 2021 Category: Drugs & Pharmacology Authors: Manish Kumar Nitin Bansal Source Type: research

A Revisit to Etiopathogenesis and Therapeutic Strategies in Alzheimer's Disease
Curr Drug Targets. 2021 Nov 18. doi: 10.2174/1389450122666211118125233. Online ahead of print.ABSTRACTDementia is a cluster of brain abnormalities that trigger progressive memory deficits and other cognitive abilities such as skills, language, or executive function. Alzheimer's disease (AD) is the foremost type of age-associated dementia that involves progressive neurodegeneration accompanied by profound cognitive deficits in advanced stages that severely hamper social or occupational abilities with or without the involvement of any other psychiatric condition. The last two decades witnessed a sharp increase (~123%) in mor...
Source: Current Drug Targets - November 18, 2021 Category: Drugs & Pharmacology Authors: Manish Kumar Nitin Bansal Source Type: research

A Revisit to Etiopathogenesis and Therapeutic Strategies in Alzheimer's Disease
Curr Drug Targets. 2021 Nov 18. doi: 10.2174/1389450122666211118125233. Online ahead of print.ABSTRACTDementia is a cluster of brain abnormalities that trigger progressive memory deficits and other cognitive abilities such as skills, language, or executive function. Alzheimer's disease (AD) is the foremost type of age-associated dementia that involves progressive neurodegeneration accompanied by profound cognitive deficits in advanced stages that severely hamper social or occupational abilities with or without the involvement of any other psychiatric condition. The last two decades witnessed a sharp increase (~123%) in mor...
Source: Current Drug Targets - November 18, 2021 Category: Drugs & Pharmacology Authors: Manish Kumar Nitin Bansal Source Type: research

A Revisit to Etiopathogenesis and Therapeutic Strategies in Alzheimer's Disease
Curr Drug Targets. 2021 Nov 18. doi: 10.2174/1389450122666211118125233. Online ahead of print.ABSTRACTDementia is a cluster of brain abnormalities that trigger progressive memory deficits and other cognitive abilities such as skills, language, or executive function. Alzheimer's disease (AD) is the foremost type of age-associated dementia that involves progressive neurodegeneration accompanied by profound cognitive deficits in advanced stages that severely hamper social or occupational abilities with or without the involvement of any other psychiatric condition. The last two decades witnessed a sharp increase (~123%) in mor...
Source: Current Drug Targets - November 18, 2021 Category: Drugs & Pharmacology Authors: Manish Kumar Nitin Bansal Source Type: research

A Revisit to Etiopathogenesis and Therapeutic Strategies in Alzheimer's Disease
Curr Drug Targets. 2021 Nov 18. doi: 10.2174/1389450122666211118125233. Online ahead of print.ABSTRACTDementia is a cluster of brain abnormalities that trigger progressive memory deficits and other cognitive abilities such as skills, language, or executive function. Alzheimer's disease (AD) is the foremost type of age-associated dementia that involves progressive neurodegeneration accompanied by profound cognitive deficits in advanced stages that severely hamper social or occupational abilities with or without the involvement of any other psychiatric condition. The last two decades witnessed a sharp increase (~123%) in mor...
Source: Current Drug Targets - November 18, 2021 Category: Drugs & Pharmacology Authors: Manish Kumar Nitin Bansal Source Type: research

A Revisit to Etiopathogenesis and Therapeutic Strategies in Alzheimer's Disease
Curr Drug Targets. 2021 Nov 18. doi: 10.2174/1389450122666211118125233. Online ahead of print.ABSTRACTDementia is a cluster of brain abnormalities that trigger progressive memory deficits and other cognitive abilities such as skills, language, or executive function. Alzheimer's disease (AD) is the foremost type of age-associated dementia that involves progressive neurodegeneration accompanied by profound cognitive deficits in advanced stages that severely hamper social or occupational abilities with or without the involvement of any other psychiatric condition. The last two decades witnessed a sharp increase (~123%) in mor...
Source: Current Drug Targets - November 18, 2021 Category: Drugs & Pharmacology Authors: Manish Kumar Nitin Bansal Source Type: research

A Revisit to Etiopathogenesis and Therapeutic Strategies in Alzheimer's Disease
Curr Drug Targets. 2021 Nov 18. doi: 10.2174/1389450122666211118125233. Online ahead of print.ABSTRACTDementia is a cluster of brain abnormalities that trigger progressive memory deficits and other cognitive abilities such as skills, language, or executive function. Alzheimer's disease (AD) is the foremost type of age-associated dementia that involves progressive neurodegeneration accompanied by profound cognitive deficits in advanced stages that severely hamper social or occupational abilities with or without the involvement of any other psychiatric condition. The last two decades witnessed a sharp increase (~123%) in mor...
Source: Current Drug Targets - November 18, 2021 Category: Drugs & Pharmacology Authors: Manish Kumar Nitin Bansal Source Type: research

A Revisit to Etiopathogenesis and Therapeutic Strategies in Alzheimer's Disease
Curr Drug Targets. 2021 Nov 18. doi: 10.2174/1389450122666211118125233. Online ahead of print.ABSTRACTDementia is a cluster of brain abnormalities that trigger progressive memory deficits and other cognitive abilities such as skills, language, or executive function. Alzheimer's disease (AD) is the foremost type of age-associated dementia that involves progressive neurodegeneration accompanied by profound cognitive deficits in advanced stages that severely hamper social or occupational abilities with or without the involvement of any other psychiatric condition. The last two decades witnessed a sharp increase (~123%) in mor...
Source: Current Drug Targets - November 18, 2021 Category: Drugs & Pharmacology Authors: Manish Kumar Nitin Bansal Source Type: research

Potential implications of angiotensin-converting enzyme 2 blockades on neuroinflammation in SARS-CoV-2 infection
CONCLUSION: It has been concluded that ACE2 blockade imposes neuroinflammation.PMID:34732115 | DOI:10.2174/1389450122666211103165837 (Source: Current Drug Targets)
Source: Current Drug Targets - November 4, 2021 Category: Drugs & Pharmacology Authors: Deepraj Paul Suresh Kumar Mohankumar Rhian S Thomas Chai Boon Kheng Duraiswamy Basavan Source Type: research

Potential implications of angiotensin-converting enzyme 2 blockades on neuroinflammation in SARS-CoV-2 infection
CONCLUSION: It has been concluded that ACE2 blockade imposes neuroinflammation.PMID:34732115 | DOI:10.2174/1389450122666211103165837 (Source: Current Drug Targets)
Source: Current Drug Targets - November 4, 2021 Category: Drugs & Pharmacology Authors: Deepraj Paul Suresh Kumar Mohankumar Rhian S Thomas Chai Boon Kheng Duraiswamy Basavan Source Type: research

Potential implications of angiotensin-converting enzyme 2 blockades on neuroinflammation in SARS-CoV-2 infection
CONCLUSION: It has been concluded that ACE2 blockade imposes neuroinflammation.PMID:34732115 | DOI:10.2174/1389450122666211103165837 (Source: Current Drug Targets)
Source: Current Drug Targets - November 4, 2021 Category: Drugs & Pharmacology Authors: Deepraj Paul Suresh Kumar Mohankumar Rhian S Thomas Chai Boon Kheng Duraiswamy Basavan Source Type: research

Potential implications of angiotensin-converting enzyme 2 blockades on neuroinflammation in SARS-CoV-2 infection
CONCLUSION: It has been concluded that ACE2 blockade imposes neuroinflammation.PMID:34732115 | DOI:10.2174/1389450122666211103165837 (Source: Current Drug Targets)
Source: Current Drug Targets - November 4, 2021 Category: Drugs & Pharmacology Authors: Deepraj Paul Suresh Kumar Mohankumar Rhian S Thomas Chai Boon Kheng Duraiswamy Basavan Source Type: research

Potential implications of angiotensin-converting enzyme 2 blockades on neuroinflammation in SARS-CoV-2 infection
CONCLUSION: It has been concluded that ACE2 blockade imposes neuroinflammation.PMID:34732115 | DOI:10.2174/1389450122666211103165837 (Source: Current Drug Targets)
Source: Current Drug Targets - November 4, 2021 Category: Drugs & Pharmacology Authors: Deepraj Paul Suresh Kumar Mohankumar Rhian S Thomas Chai Boon Kheng Duraiswamy Basavan Source Type: research

Potential implications of angiotensin-converting enzyme 2 blockades on neuroinflammation in SARS-CoV-2 infection
CONCLUSION: It has been concluded that ACE2 blockade imposes neuroinflammation.PMID:34732115 | DOI:10.2174/1389450122666211103165837 (Source: Current Drug Targets)
Source: Current Drug Targets - November 4, 2021 Category: Drugs & Pharmacology Authors: Deepraj Paul Suresh Kumar Mohankumar Rhian S Thomas Chai Boon Kheng Duraiswamy Basavan Source Type: research

Potential implications of angiotensin-converting enzyme 2 blockades on neuroinflammation in SARS-CoV-2 infection
CONCLUSION: It has been concluded that ACE2 blockade imposes neuroinflammation.PMID:34732115 | DOI:10.2174/1389450122666211103165837 (Source: Current Drug Targets)
Source: Current Drug Targets - November 4, 2021 Category: Drugs & Pharmacology Authors: Deepraj Paul Suresh Kumar Mohankumar Rhian S Thomas Chai Boon Kheng Duraiswamy Basavan Source Type: research

Potential implications of angiotensin-converting enzyme 2 blockades on neuroinflammation in SARS-CoV-2 infection
CONCLUSION: It has been concluded that ACE2 blockade imposes neuroinflammation.PMID:34732115 | DOI:10.2174/1389450122666211103165837 (Source: Current Drug Targets)
Source: Current Drug Targets - November 4, 2021 Category: Drugs & Pharmacology Authors: Deepraj Paul Suresh Kumar Mohankumar Rhian S Thomas Chai Boon Kheng Duraiswamy Basavan Source Type: research

Potential implications of angiotensin-converting enzyme 2 blockades on neuroinflammation in SARS-CoV-2 infection
CONCLUSION: It has been concluded that ACE2 blockade imposes neuroinflammation.PMID:34732115 | DOI:10.2174/1389450122666211103165837 (Source: Current Drug Targets)
Source: Current Drug Targets - November 4, 2021 Category: Drugs & Pharmacology Authors: Deepraj Paul Suresh Kumar Mohankumar Rhian S Thomas Chai Boon Kheng Duraiswamy Basavan Source Type: research

Potential implications of angiotensin-converting enzyme 2 blockades on neuroinflammation in SARS-CoV-2 infection
CONCLUSION: It has been concluded that ACE2 blockade imposes neuroinflammation.PMID:34732115 | DOI:10.2174/1389450122666211103165837 (Source: Current Drug Targets)
Source: Current Drug Targets - November 4, 2021 Category: Drugs & Pharmacology Authors: Deepraj Paul Suresh Kumar Mohankumar Rhian S Thomas Chai Boon Kheng Duraiswamy Basavan Source Type: research

Potential implications of angiotensin-converting enzyme 2 blockades on neuroinflammation in SARS-CoV-2 infection
CONCLUSION: It has been concluded that ACE2 blockade imposes neuroinflammation.PMID:34732115 | DOI:10.2174/1389450122666211103165837 (Source: Current Drug Targets)
Source: Current Drug Targets - November 4, 2021 Category: Drugs & Pharmacology Authors: Deepraj Paul Suresh Kumar Mohankumar Rhian S Thomas Chai Boon Kheng Duraiswamy Basavan Source Type: research

Promising Protective Effects of Chrysin in Cardiometabolic Diseases
Curr Drug Targets. 2021 Oct 5. doi: 10.2174/1389450122666211005113234. Online ahead of print.ABSTRACTCardiometabolic diseases (CMD) have a great burden in terms of morbidity and mortality worldwide. The vicious cycle of CMD consists of type II diabetes, hypertension, dyslipidemia, obesity, and atherosclerosis interacting and feedbacking each other. The natural flavonoid chrysin has been displayed to own a broad spectrum of therapeutic impacts for human health. Herein, we did an in-depth investigation of the novel mechanisms of chrysin's cardioprotection against cardiometabolic disorder. Studies have shown that chrysin prot...
Source: Current Drug Targets - October 12, 2021 Category: Drugs & Pharmacology Authors: Marjan Talebi Mohsen Talebi Tahereh Farkhondeh Jesus Simal-Gandara Dalia M Kopustinskiene Jurga Bernatoniene Ali Mohammad Pourbagher-Shahri Saeed Samarghandian Source Type: research

The Extracapsular Lymph Node Extension Predicts Outcomes in Colorectal Cancer: A Short Review
Conclusion We, therefore, propose to carry out randomized clinical trials to study this subject better and strengthen its value in management strategies.PMID:34636296 | DOI:10.2174/1389450122666211005114122 (Source: Current Drug Targets)
Source: Current Drug Targets - October 12, 2021 Category: Drugs & Pharmacology Authors: Rachid Jabi Ouissam Al Jarroudi Mohammed Bouziane Source Type: research

A Mechanistic Review on Plant-derived Natural Inhibitors of Human Coronaviruses with Emphasis on SARS-COV-1 and SARS-COV-2
Curr Drug Targets. 2021 Oct 5. doi: 10.2174/1389450122666211005115313. Online ahead of print.ABSTRACTCoronaviruses have been receiving continuous attention worldwide as they have caused a serious threat to global public health. This group of viruses is named so as they exhibit characteristic crown-like spikes on their protein coat. SARS-CoV-2, a type of coronavirus that emerged in 2019, causes severe infection in the lower respiratory tract of humans and is often fatal in immunocompromised individuals. No medications have been approved so far for the direct treatment of SARS-CoV-2 infection, and the currently available tre...
Source: Current Drug Targets - October 12, 2021 Category: Drugs & Pharmacology Authors: Sai Krishna Guguloth None Lakshmi A R Radhika Rajendran Kaushik Rajaram Thirunavukkarasu Chinnasamy Jian-Dong Huang Hongjie Zhang Sanjib Senapati Siva Sundara Kumar Durairajan Source Type: research

Promising Protective Effects of Chrysin in Cardiometabolic Diseases
Curr Drug Targets. 2021 Oct 5. doi: 10.2174/1389450122666211005113234. Online ahead of print.ABSTRACTCardiometabolic diseases (CMD) have a great burden in terms of morbidity and mortality worldwide. The vicious cycle of CMD consists of type II diabetes, hypertension, dyslipidemia, obesity, and atherosclerosis interacting and feedbacking each other. The natural flavonoid chrysin has been displayed to own a broad spectrum of therapeutic impacts for human health. Herein, we did an in-depth investigation of the novel mechanisms of chrysin's cardioprotection against cardiometabolic disorder. Studies have shown that chrysin prot...
Source: Current Drug Targets - October 12, 2021 Category: Drugs & Pharmacology Authors: Marjan Talebi Mohsen Talebi Tahereh Farkhondeh Jesus Simal-Gandara Dalia M Kopustinskiene Jurga Bernatoniene Ali Mohammad Pourbagher-Shahri Saeed Samarghandian Source Type: research

The Extracapsular Lymph Node Extension Predicts Outcomes in Colorectal Cancer: A Short Review
Conclusion We, therefore, propose to carry out randomized clinical trials to study this subject better and strengthen its value in management strategies.PMID:34636296 | DOI:10.2174/1389450122666211005114122 (Source: Current Drug Targets)
Source: Current Drug Targets - October 12, 2021 Category: Drugs & Pharmacology Authors: Rachid Jabi Ouissam Al Jarroudi Mohammed Bouziane Source Type: research

A Mechanistic Review on Plant-derived Natural Inhibitors of Human Coronaviruses with Emphasis on SARS-COV-1 and SARS-COV-2
Curr Drug Targets. 2021 Oct 5. doi: 10.2174/1389450122666211005115313. Online ahead of print.ABSTRACTCoronaviruses have been receiving continuous attention worldwide as they have caused a serious threat to global public health. This group of viruses is named so as they exhibit characteristic crown-like spikes on their protein coat. SARS-CoV-2, a type of coronavirus that emerged in 2019, causes severe infection in the lower respiratory tract of humans and is often fatal in immunocompromised individuals. No medications have been approved so far for the direct treatment of SARS-CoV-2 infection, and the currently available tre...
Source: Current Drug Targets - October 12, 2021 Category: Drugs & Pharmacology Authors: Sai Krishna Guguloth None Lakshmi A R Radhika Rajendran Kaushik Rajaram Thirunavukkarasu Chinnasamy Jian-Dong Huang Hongjie Zhang Sanjib Senapati Siva Sundara Kumar Durairajan Source Type: research

Promising Protective Effects of Chrysin in Cardiometabolic Diseases
Curr Drug Targets. 2021 Oct 5. doi: 10.2174/1389450122666211005113234. Online ahead of print.ABSTRACTCardiometabolic diseases (CMD) have a great burden in terms of morbidity and mortality worldwide. The vicious cycle of CMD consists of type II diabetes, hypertension, dyslipidemia, obesity, and atherosclerosis interacting and feedbacking each other. The natural flavonoid chrysin has been displayed to own a broad spectrum of therapeutic impacts for human health. Herein, we did an in-depth investigation of the novel mechanisms of chrysin's cardioprotection against cardiometabolic disorder. Studies have shown that chrysin prot...
Source: Current Drug Targets - October 12, 2021 Category: Drugs & Pharmacology Authors: Marjan Talebi Mohsen Talebi Tahereh Farkhondeh Jesus Simal-Gandara Dalia M Kopustinskiene Jurga Bernatoniene Ali Mohammad Pourbagher-Shahri Saeed Samarghandian Source Type: research

The Extracapsular Lymph Node Extension Predicts Outcomes in Colorectal Cancer: A Short Review
Conclusion We, therefore, propose to carry out randomized clinical trials to study this subject better and strengthen its value in management strategies.PMID:34636296 | DOI:10.2174/1389450122666211005114122 (Source: Current Drug Targets)
Source: Current Drug Targets - October 12, 2021 Category: Drugs & Pharmacology Authors: Rachid Jabi Ouissam Al Jarroudi Mohammed Bouziane Source Type: research

A Mechanistic Review on Plant-derived Natural Inhibitors of Human Coronaviruses with Emphasis on SARS-COV-1 and SARS-COV-2
Curr Drug Targets. 2021 Oct 5. doi: 10.2174/1389450122666211005115313. Online ahead of print.ABSTRACTCoronaviruses have been receiving continuous attention worldwide as they have caused a serious threat to global public health. This group of viruses is named so as they exhibit characteristic crown-like spikes on their protein coat. SARS-CoV-2, a type of coronavirus that emerged in 2019, causes severe infection in the lower respiratory tract of humans and is often fatal in immunocompromised individuals. No medications have been approved so far for the direct treatment of SARS-CoV-2 infection, and the currently available tre...
Source: Current Drug Targets - October 12, 2021 Category: Drugs & Pharmacology Authors: Sai Krishna Guguloth None Lakshmi A R Radhika Rajendran Kaushik Rajaram Thirunavukkarasu Chinnasamy Jian-Dong Huang Hongjie Zhang Sanjib Senapati Siva Sundara Kumar Durairajan Source Type: research

Promising Protective Effects of Chrysin in Cardiometabolic Diseases
Curr Drug Targets. 2021 Oct 5. doi: 10.2174/1389450122666211005113234. Online ahead of print.ABSTRACTCardiometabolic diseases (CMD) have a great burden in terms of morbidity and mortality worldwide. The vicious cycle of CMD consists of type II diabetes, hypertension, dyslipidemia, obesity, and atherosclerosis interacting and feedbacking each other. The natural flavonoid chrysin has been displayed to own a broad spectrum of therapeutic impacts for human health. Herein, we did an in-depth investigation of the novel mechanisms of chrysin's cardioprotection against cardiometabolic disorder. Studies have shown that chrysin prot...
Source: Current Drug Targets - October 12, 2021 Category: Drugs & Pharmacology Authors: Marjan Talebi Mohsen Talebi Tahereh Farkhondeh Jesus Simal-Gandara Dalia M Kopustinskiene Jurga Bernatoniene Ali Mohammad Pourbagher-Shahri Saeed Samarghandian Source Type: research

The Extracapsular Lymph Node Extension Predicts Outcomes in Colorectal Cancer: A Short Review
Conclusion We, therefore, propose to carry out randomized clinical trials to study this subject better and strengthen its value in management strategies.PMID:34636296 | DOI:10.2174/1389450122666211005114122 (Source: Current Drug Targets)
Source: Current Drug Targets - October 12, 2021 Category: Drugs & Pharmacology Authors: Rachid Jabi Ouissam Al Jarroudi Mohammed Bouziane Source Type: research

A Mechanistic Review on Plant-derived Natural Inhibitors of Human Coronaviruses with Emphasis on SARS-COV-1 and SARS-COV-2
Curr Drug Targets. 2021 Oct 5. doi: 10.2174/1389450122666211005115313. Online ahead of print.ABSTRACTCoronaviruses have been receiving continuous attention worldwide as they have caused a serious threat to global public health. This group of viruses is named so as they exhibit characteristic crown-like spikes on their protein coat. SARS-CoV-2, a type of coronavirus that emerged in 2019, causes severe infection in the lower respiratory tract of humans and is often fatal in immunocompromised individuals. No medications have been approved so far for the direct treatment of SARS-CoV-2 infection, and the currently available tre...
Source: Current Drug Targets - October 12, 2021 Category: Drugs & Pharmacology Authors: Sai Krishna Guguloth None Lakshmi A R Radhika Rajendran Kaushik Rajaram Thirunavukkarasu Chinnasamy Jian-Dong Huang Hongjie Zhang Sanjib Senapati Siva Sundara Kumar Durairajan Source Type: research

Promising Protective Effects of Chrysin in Cardiometabolic Diseases
Curr Drug Targets. 2021 Oct 5. doi: 10.2174/1389450122666211005113234. Online ahead of print.ABSTRACTCardiometabolic diseases (CMD) have a great burden in terms of morbidity and mortality worldwide. The vicious cycle of CMD consists of type II diabetes, hypertension, dyslipidemia, obesity, and atherosclerosis interacting and feedbacking each other. The natural flavonoid chrysin has been displayed to own a broad spectrum of therapeutic impacts for human health. Herein, we did an in-depth investigation of the novel mechanisms of chrysin's cardioprotection against cardiometabolic disorder. Studies have shown that chrysin prot...
Source: Current Drug Targets - October 12, 2021 Category: Drugs & Pharmacology Authors: Marjan Talebi Mohsen Talebi Tahereh Farkhondeh Jesus Simal-Gandara Dalia M Kopustinskiene Jurga Bernatoniene Ali Mohammad Pourbagher-Shahri Saeed Samarghandian Source Type: research

The Extracapsular Lymph Node Extension Predicts Outcomes in Colorectal Cancer: A Short Review
Conclusion We, therefore, propose to carry out randomized clinical trials to study this subject better and strengthen its value in management strategies.PMID:34636296 | DOI:10.2174/1389450122666211005114122 (Source: Current Drug Targets)
Source: Current Drug Targets - October 12, 2021 Category: Drugs & Pharmacology Authors: Rachid Jabi Ouissam Al Jarroudi Mohammed Bouziane Source Type: research

A Mechanistic Review on Plant-derived Natural Inhibitors of Human Coronaviruses with Emphasis on SARS-COV-1 and SARS-COV-2
Curr Drug Targets. 2021 Oct 5. doi: 10.2174/1389450122666211005115313. Online ahead of print.ABSTRACTCoronaviruses have been receiving continuous attention worldwide as they have caused a serious threat to global public health. This group of viruses is named so as they exhibit characteristic crown-like spikes on their protein coat. SARS-CoV-2, a type of coronavirus that emerged in 2019, causes severe infection in the lower respiratory tract of humans and is often fatal in immunocompromised individuals. No medications have been approved so far for the direct treatment of SARS-CoV-2 infection, and the currently available tre...
Source: Current Drug Targets - October 12, 2021 Category: Drugs & Pharmacology Authors: Sai Krishna Guguloth None Lakshmi A R Radhika Rajendran Kaushik Rajaram Thirunavukkarasu Chinnasamy Jian-Dong Huang Hongjie Zhang Sanjib Senapati Siva Sundara Kumar Durairajan Source Type: research

Promising Protective Effects of Chrysin in Cardiometabolic Diseases
Curr Drug Targets. 2021 Oct 5. doi: 10.2174/1389450122666211005113234. Online ahead of print.ABSTRACTCardiometabolic diseases (CMD) have a great burden in terms of morbidity and mortality worldwide. The vicious cycle of CMD consists of type II diabetes, hypertension, dyslipidemia, obesity, and atherosclerosis interacting and feedbacking each other. The natural flavonoid chrysin has been displayed to own a broad spectrum of therapeutic impacts for human health. Herein, we did an in-depth investigation of the novel mechanisms of chrysin's cardioprotection against cardiometabolic disorder. Studies have shown that chrysin prot...
Source: Current Drug Targets - October 12, 2021 Category: Drugs & Pharmacology Authors: Marjan Talebi Mohsen Talebi Tahereh Farkhondeh Jesus Simal-Gandara Dalia M Kopustinskiene Jurga Bernatoniene Ali Mohammad Pourbagher-Shahri Saeed Samarghandian Source Type: research

The Extracapsular Lymph Node Extension Predicts Outcomes in Colorectal Cancer: A Short Review
Conclusion We, therefore, propose to carry out randomized clinical trials to study this subject better and strengthen its value in management strategies.PMID:34636296 | DOI:10.2174/1389450122666211005114122 (Source: Current Drug Targets)
Source: Current Drug Targets - October 12, 2021 Category: Drugs & Pharmacology Authors: Rachid Jabi Ouissam Al Jarroudi Mohammed Bouziane Source Type: research

A Mechanistic Review on Plant-derived Natural Inhibitors of Human Coronaviruses with Emphasis on SARS-COV-1 and SARS-COV-2
Curr Drug Targets. 2021 Oct 5. doi: 10.2174/1389450122666211005115313. Online ahead of print.ABSTRACTCoronaviruses have been receiving continuous attention worldwide as they have caused a serious threat to global public health. This group of viruses is named so as they exhibit characteristic crown-like spikes on their protein coat. SARS-CoV-2, a type of coronavirus that emerged in 2019, causes severe infection in the lower respiratory tract of humans and is often fatal in immunocompromised individuals. No medications have been approved so far for the direct treatment of SARS-CoV-2 infection, and the currently available tre...
Source: Current Drug Targets - October 12, 2021 Category: Drugs & Pharmacology Authors: Sai Krishna Guguloth None Lakshmi A R Radhika Rajendran Kaushik Rajaram Thirunavukkarasu Chinnasamy Jian-Dong Huang Hongjie Zhang Sanjib Senapati Siva Sundara Kumar Durairajan Source Type: research

Promising Protective Effects of Chrysin in Cardiometabolic Diseases
Curr Drug Targets. 2021 Oct 5. doi: 10.2174/1389450122666211005113234. Online ahead of print.ABSTRACTCardiometabolic diseases (CMD) have a great burden in terms of morbidity and mortality worldwide. The vicious cycle of CMD consists of type II diabetes, hypertension, dyslipidemia, obesity, and atherosclerosis interacting and feedbacking each other. The natural flavonoid chrysin has been displayed to own a broad spectrum of therapeutic impacts for human health. Herein, we did an in-depth investigation of the novel mechanisms of chrysin's cardioprotection against cardiometabolic disorder. Studies have shown that chrysin prot...
Source: Current Drug Targets - October 12, 2021 Category: Drugs & Pharmacology Authors: Marjan Talebi Mohsen Talebi Tahereh Farkhondeh Jesus Simal-Gandara Dalia M Kopustinskiene Jurga Bernatoniene Ali Mohammad Pourbagher-Shahri Saeed Samarghandian Source Type: research

The Extracapsular Lymph Node Extension Predicts Outcomes in Colorectal Cancer: A Short Review
Conclusion We, therefore, propose to carry out randomized clinical trials to study this subject better and strengthen its value in management strategies.PMID:34636296 | DOI:10.2174/1389450122666211005114122 (Source: Current Drug Targets)
Source: Current Drug Targets - October 12, 2021 Category: Drugs & Pharmacology Authors: Rachid Jabi Ouissam Al Jarroudi Mohammed Bouziane Source Type: research

A Mechanistic Review on Plant-derived Natural Inhibitors of Human Coronaviruses with Emphasis on SARS-COV-1 and SARS-COV-2
Curr Drug Targets. 2021 Oct 5. doi: 10.2174/1389450122666211005115313. Online ahead of print.ABSTRACTCoronaviruses have been receiving continuous attention worldwide as they have caused a serious threat to global public health. This group of viruses is named so as they exhibit characteristic crown-like spikes on their protein coat. SARS-CoV-2, a type of coronavirus that emerged in 2019, causes severe infection in the lower respiratory tract of humans and is often fatal in immunocompromised individuals. No medications have been approved so far for the direct treatment of SARS-CoV-2 infection, and the currently available tre...
Source: Current Drug Targets - October 12, 2021 Category: Drugs & Pharmacology Authors: Sai Krishna Guguloth None Lakshmi A R Radhika Rajendran Kaushik Rajaram Thirunavukkarasu Chinnasamy Jian-Dong Huang Hongjie Zhang Sanjib Senapati Siva Sundara Kumar Durairajan Source Type: research

Promising Protective Effects of Chrysin in Cardiometabolic Diseases
Curr Drug Targets. 2021 Oct 5. doi: 10.2174/1389450122666211005113234. Online ahead of print.ABSTRACTCardiometabolic diseases (CMD) have a great burden in terms of morbidity and mortality worldwide. The vicious cycle of CMD consists of type II diabetes, hypertension, dyslipidemia, obesity, and atherosclerosis interacting and feedbacking each other. The natural flavonoid chrysin has been displayed to own a broad spectrum of therapeutic impacts for human health. Herein, we did an in-depth investigation of the novel mechanisms of chrysin's cardioprotection against cardiometabolic disorder. Studies have shown that chrysin prot...
Source: Current Drug Targets - October 12, 2021 Category: Drugs & Pharmacology Authors: Marjan Talebi Mohsen Talebi Tahereh Farkhondeh Jesus Simal-Gandara Dalia M Kopustinskiene Jurga Bernatoniene Ali Mohammad Pourbagher-Shahri Saeed Samarghandian Source Type: research

The Extracapsular Lymph Node Extension Predicts Outcomes in Colorectal Cancer: A Short Review
Conclusion We, therefore, propose to carry out randomized clinical trials to study this subject better and strengthen its value in management strategies.PMID:34636296 | DOI:10.2174/1389450122666211005114122 (Source: Current Drug Targets)
Source: Current Drug Targets - October 12, 2021 Category: Drugs & Pharmacology Authors: Rachid Jabi Ouissam Al Jarroudi Mohammed Bouziane Source Type: research

A Mechanistic Review on Plant-derived Natural Inhibitors of Human Coronaviruses with Emphasis on SARS-COV-1 and SARS-COV-2
Curr Drug Targets. 2021 Oct 5. doi: 10.2174/1389450122666211005115313. Online ahead of print.ABSTRACTCoronaviruses have been receiving continuous attention worldwide as they have caused a serious threat to global public health. This group of viruses is named so as they exhibit characteristic crown-like spikes on their protein coat. SARS-CoV-2, a type of coronavirus that emerged in 2019, causes severe infection in the lower respiratory tract of humans and is often fatal in immunocompromised individuals. No medications have been approved so far for the direct treatment of SARS-CoV-2 infection, and the currently available tre...
Source: Current Drug Targets - October 12, 2021 Category: Drugs & Pharmacology Authors: Sai Krishna Guguloth None Lakshmi A R Radhika Rajendran Kaushik Rajaram Thirunavukkarasu Chinnasamy Jian-Dong Huang Hongjie Zhang Sanjib Senapati Siva Sundara Kumar Durairajan Source Type: research

Promising Protective Effects of Chrysin in Cardiometabolic Diseases
Curr Drug Targets. 2021 Oct 5. doi: 10.2174/1389450122666211005113234. Online ahead of print.ABSTRACTCardiometabolic diseases (CMD) have a great burden in terms of morbidity and mortality worldwide. The vicious cycle of CMD consists of type II diabetes, hypertension, dyslipidemia, obesity, and atherosclerosis interacting and feedbacking each other. The natural flavonoid chrysin has been displayed to own a broad spectrum of therapeutic impacts for human health. Herein, we did an in-depth investigation of the novel mechanisms of chrysin's cardioprotection against cardiometabolic disorder. Studies have shown that chrysin prot...
Source: Current Drug Targets - October 12, 2021 Category: Drugs & Pharmacology Authors: Marjan Talebi Mohsen Talebi Tahereh Farkhondeh Jesus Simal-Gandara Dalia M Kopustinskiene Jurga Bernatoniene Ali Mohammad Pourbagher-Shahri Saeed Samarghandian Source Type: research