Antiviral Potential of Traditional Unani Medicine in Viral Diseases with Special Emphasis on Dengue: A Review
Curr Drug Targets. 2023 Nov 21. doi: 10.2174/0113894501257577231103044735. Online ahead of print.ABSTRACTDengue fever has become a major public health concern. It is usually related to intravascular leaking, bleeding disorders, and thrombocytopenia and is recognized as a potent threat to humans. The scarcity of anti-dengue medication or vaccine for such a serious disease leads to an upsurge in the usage of traditional medicines for its proper management. India has diverse biodiversity and a long history of using plant-based remedies. Several medicinal plant extracts have been studied for producing anti-dengue viral activit...
Source: Current Drug Targets - December 1, 2023 Category: Drugs & Pharmacology Authors: Muzayyana Khan Mohammad Altamish Monalisha Samal Varsha Srivastava Areeba Insaf Rabea Parveen Jamal Akhtar Anuja Krishnan Sayeed Ahmad Source Type: research
Flavonoids as G Protein-coupled Receptors Ligands: New Potential Therapeutic Natural Drugs
Curr Drug Targets. 2023 Nov 30. doi: 10.2174/0113894501268871231127105219. Online ahead of print.ABSTRACTG protein coupled receptors (GPCRs) are among the largest family of cell surface re-ceptors found in the human genome. They govern a wide range of physiological responses in both health and diseases, making them one of the potential targeted surface receptors for pharmaceuti-cals. Flavonoids can modulate GPCRs activity by acting as allosteric ligands. They can either en-hance or reduce the GPCR's effect. Emerging research shows that individual flavonoids or mix-tures of flavonoids from plant extract can have relevant ph...
Source: Current Drug Targets - December 1, 2023 Category: Drugs & Pharmacology Authors: Rachid Bencheikh Alae Chda Source Type: research
Novel Targets and Drug Delivery System in the Treatment of Postoperative Pain: Recent Studies and Clinical Advancement
Curr Drug Targets. 2023 Nov 30. doi: 10.2174/0113894501271207231127063431. Online ahead of print.ABSTRACTPain is generated by a small number of peripheral targets. These can be made more sensitive by inflammatory mediators. The number of opioids prescribed to the patients can be reduced dramatically with better pain management. Any therapy that safely and reliably provides extended analgesia and is flexible enough to facilitate a diverse array of release profiles would be useful for improving patient comfort, quality of care, and compliance after surgical procedures. Comparisons are made between new and traditional methods...
Source: Current Drug Targets - December 1, 2023 Category: Drugs & Pharmacology Authors: Trilochan Satapathy Gulab Singh Ravindra Kumar Pandey Shiv Shankar Shukla Shiv Kumar Bhardwaj Beena Gidwani Source Type: research
The Development of the Combination Drug Leukovir ® Tablets for the Treatment of Multiple Sclerosis: A Comprehensive Review
Curr Drug Targets. 2023 Nov 30. doi: 10.2174/0113894501272301231124074141. Online ahead of print.ABSTRACTThe review is devoted to the development and study of the drug Leukovir® (cladribine+ ribavirin) and its use in the treatment of relapsing-remitting and secondary progressive forms of multiple sclerosis, a chronic neurodegenerative disease aiming the risk reduction of relapse and progression of a disability. In clinical trials Leukovir® has proved to be efficient by up to 56 weeks for the treatment of relapsing-remitting and secondary progressive forms of multiple sclerosis. The drug is registered in the Republic of B...
Source: Current Drug Targets - December 1, 2023 Category: Drugs & Pharmacology Authors: Elena Kalinichenko Svetlana Babitskaya Source Type: research
Biological Potential and Therapeutic Effectiveness of Geiparvarin in Medicine for its Anti-proliferative Activity against Tumors and Other Human Complications
Curr Drug Targets. 2023 Nov 30. doi: 10.2174/0113894501271142231120065852. Online ahead of print.NO ABSTRACTPMID:38037997 | DOI:10.2174/0113894501271142231120065852 (Source: Current Drug Targets)
Source: Current Drug Targets - December 1, 2023 Category: Drugs & Pharmacology Authors: Dinesh Kumar Patel Source Type: research
Deciphering the Function of New Therapeutic Targets and Prospective Biomarkers in the Management of Psoriasis
Curr Drug Targets. 2023 Nov 30. doi: 10.2174/0113894501277656231128060242. Online ahead of print.ABSTRACTPsoriasis is an immune-mediated skin condition affecting people worldwide, presenting at any age, and leading to a substantial burden physically and mentally. The innate and adaptive immune systems interact intricately with the pathomechanisms that underlie disease. T cells can interact with keratinocytes, macrophages, and dendritic cells through the cytokines they secrete. According to recent research, psoriasis flare-ups can cause systemic inflammation and various other co-morbidities, including depression, psoriatic ...
Source: Current Drug Targets - December 1, 2023 Category: Drugs & Pharmacology Authors: Japneet Singh Purewal Gaurav Mahesh Doshi Source Type: research
Syndecan-1: A Novel Diagnostic and Therapeutic Target in Liver Diseases
Curr Drug Targets. 2023 Nov 7. doi: 10.2174/0113894501250057231102061624. Online ahead of print.ABSTRACTSyndecan-1 (SDC-1), known as a coreceptor of various growth factors or an integrin binding partner, regulates various cell behaviours. Under certain pathological conditions, SDC-1 is shed from the cell surface and plays a protective or pathogenic role in various diseases. In the liver, SDC-1 is highly expressed in hepatocytes, where it is localized on the basolateral surface. It is critical to the cellular and molecular functions of hepatocytes, including their attachment to hepatitis viruses. Previous studies have repor...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Xiaoli Zhang Yalei Zhao Liangru Liu Yingli He Source Type: research
Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing
Curr Drug Targets. 2023 Nov 9. doi: 10.2174/0113894501260002231101080505. Online ahead of print.ABSTRACTThe diabetic wound is excessively vulnerable to infection because the diabetic wound suggests delayed and incomplete healing techniques. Presently, wounds and ulcers related to diabetes have additionally increased the medical burden. A diabetic wound can impair mobility, lead to amputations, or even death. In recent times, advanced drug delivery systems have emerged as promising approaches for enhancing the efficacy of wound healing treatments in diabetic patients. This review aims to provide an overview of the current a...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Harish Bhardwaj Sulekha Khute Ram Sahu Rajendra Kumar Jangde Source Type: research
Radical Scavenging, Anti-Inflammatory, and Hepatoprotective Activities of Pentacyclic Triterpene isolated from Rosa webbiana
CONCLUSION: The compound ARW1 exhibited anti-radical, anti-inflammatory and hepatoprotective effects. The anti-inflammatory and hepatoprotective activities may be attributed to anti-oxidant potential of the compound.PMID:37957908 | DOI:10.2174/0113894501261030231101184216 (Source: Current Drug Targets)
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Abdullah Khan Mir Azam Khan Achyut Adhikari Source Type: research
Syndecan-1: A Novel Diagnostic and Therapeutic Target in Liver Diseases
Curr Drug Targets. 2023 Nov 7. doi: 10.2174/0113894501250057231102061624. Online ahead of print.ABSTRACTSyndecan-1 (SDC-1), known as a coreceptor of various growth factors or an integrin binding partner, regulates various cell behaviours. Under certain pathological conditions, SDC-1 is shed from the cell surface and plays a protective or pathogenic role in various diseases. In the liver, SDC-1 is highly expressed in hepatocytes, where it is localized on the basolateral surface. It is critical to the cellular and molecular functions of hepatocytes, including their attachment to hepatitis viruses. Previous studies have repor...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Xiaoli Zhang Yalei Zhao Liangru Liu Yingli He Source Type: research
Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing
Curr Drug Targets. 2023 Nov 9. doi: 10.2174/0113894501260002231101080505. Online ahead of print.ABSTRACTThe diabetic wound is excessively vulnerable to infection because the diabetic wound suggests delayed and incomplete healing techniques. Presently, wounds and ulcers related to diabetes have additionally increased the medical burden. A diabetic wound can impair mobility, lead to amputations, or even death. In recent times, advanced drug delivery systems have emerged as promising approaches for enhancing the efficacy of wound healing treatments in diabetic patients. This review aims to provide an overview of the current a...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Harish Bhardwaj Sulekha Khute Ram Sahu Rajendra Kumar Jangde Source Type: research
Radical Scavenging, Anti-Inflammatory, and Hepatoprotective Activities of Pentacyclic Triterpene isolated from Rosa webbiana
CONCLUSION: The compound ARW1 exhibited anti-radical, anti-inflammatory and hepatoprotective effects. The anti-inflammatory and hepatoprotective activities may be attributed to anti-oxidant potential of the compound.PMID:37957908 | DOI:10.2174/0113894501261030231101184216 (Source: Current Drug Targets)
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Abdullah Khan Mir Azam Khan Achyut Adhikari Source Type: research
Syndecan-1: A Novel Diagnostic and Therapeutic Target in Liver Diseases
Curr Drug Targets. 2023 Nov 7. doi: 10.2174/0113894501250057231102061624. Online ahead of print.ABSTRACTSyndecan-1 (SDC-1), known as a coreceptor of various growth factors or an integrin binding partner, regulates various cell behaviours. Under certain pathological conditions, SDC-1 is shed from the cell surface and plays a protective or pathogenic role in various diseases. In the liver, SDC-1 is highly expressed in hepatocytes, where it is localized on the basolateral surface. It is critical to the cellular and molecular functions of hepatocytes, including their attachment to hepatitis viruses. Previous studies have repor...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Xiaoli Zhang Yalei Zhao Liangru Liu Yingli He Source Type: research
Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing
Curr Drug Targets. 2023 Nov 9. doi: 10.2174/0113894501260002231101080505. Online ahead of print.ABSTRACTThe diabetic wound is excessively vulnerable to infection because the diabetic wound suggests delayed and incomplete healing techniques. Presently, wounds and ulcers related to diabetes have additionally increased the medical burden. A diabetic wound can impair mobility, lead to amputations, or even death. In recent times, advanced drug delivery systems have emerged as promising approaches for enhancing the efficacy of wound healing treatments in diabetic patients. This review aims to provide an overview of the current a...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Harish Bhardwaj Sulekha Khute Ram Sahu Rajendra Kumar Jangde Source Type: research
Radical Scavenging, Anti-Inflammatory, and Hepatoprotective Activities of Pentacyclic Triterpene isolated from Rosa webbiana
CONCLUSION: The compound ARW1 exhibited anti-radical, anti-inflammatory and hepatoprotective effects. The anti-inflammatory and hepatoprotective activities may be attributed to anti-oxidant potential of the compound.PMID:37957908 | DOI:10.2174/0113894501261030231101184216 (Source: Current Drug Targets)
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Abdullah Khan Mir Azam Khan Achyut Adhikari Source Type: research
