Role of γ-Secretase Inhibitors for the Treatment of Diverse Disease Conditions through Inhibition of Notch Signaling Pathway
Curr Drug Targets. 2021 May 15. doi: 10.2174/1389450122666210515161312. Online ahead of print.ABSTRACTγ-Secretase is an intramembrane protease sub-assembly which that sunders transmembrane proteins. They are involved in intramembrane proteolysis and also contribute to the regeneration of transmembrane protein. The amyloid precursor protein (APP) is a typical γ-secretase substrate. These proteins are cleaved to produce 36-43 amyloid-beta (Aβ) amino acid peptides. Abnormal folding of these protein fragments leads to amyloid plaques; , frequently encountered in Alzheimer's disease. Some Type I class of integr...
Source: Current Drug Targets - May 16, 2021 Category: Drugs & Pharmacology Authors: Arijit Mondal Sankhadip Bose Sabyasachi Banerjee Dilipkumar Pal Source Type: research

Microsatellite Instability as a Predictor of Outcomes in Colorectal Cancer in the Era of Immune-Checkpoint Inhibitors
Curr Drug Targets. 2021 Mar 24. doi: 10.2174/1389450122666210325121322. Online ahead of print.ABSTRACTThe microsatellite instable phenotype resulting from errors in DNA mismatch repair proteins accounts for as far as 15 to 20% of non-hereditary colon cancers but is scarce in rectal cancer. It has been shown that the increased existence of tumor-specific neoantigens in hypermutated tumors is correlated with higher tumor-infiltrating lymphocytes (TILs) and overexpression of immune checkpoint receptors and ligands, mainly PD-1 and PD-L1. In particular, the data gained up to now gives evidence that neoantigen recognition const...
Source: Current Drug Targets - May 10, 2021 Category: Drugs & Pharmacology Authors: Csongor Gy örgy Lengyel Source Type: research

Microsatellite Instability as a Predictor of Outcomes in Colorectal Cancer in the Era of Immune-Checkpoint Inhibitors
Curr Drug Targets. 2021 Mar 24. doi: 10.2174/1389450122666210325121322. Online ahead of print.ABSTRACTThe microsatellite instable phenotype resulting from errors in DNA mismatch repair proteins accounts for as far as 15 to 20% of non-hereditary colon cancers but is scarce in rectal cancer. It has been shown that the increased existence of tumor-specific neoantigens in hypermutated tumors is correlated with higher tumor-infiltrating lymphocytes (TILs) and overexpression of immune checkpoint receptors and ligands, mainly PD-1 and PD-L1. In particular, the data gained up to now gives evidence that neoantigen recognition const...
Source: Current Drug Targets - May 10, 2021 Category: Drugs & Pharmacology Authors: Csongor Gy örgy Lengyel Source Type: research

Microsatellite Instability as a Predictor of Outcomes in Colorectal Cancer in the Era of Immune-Checkpoint Inhibitors
Curr Drug Targets. 2021 Mar 24. doi: 10.2174/1389450122666210325121322. Online ahead of print.ABSTRACTThe microsatellite instable phenotype resulting from errors in DNA mismatch repair proteins accounts for as far as 15 to 20% of non-hereditary colon cancers but is scarce in rectal cancer. It has been shown that the increased existence of tumor-specific neoantigens in hypermutated tumors is correlated with higher tumor-infiltrating lymphocytes (TILs) and overexpression of immune checkpoint receptors and ligands, mainly PD-1 and PD-L1. In particular, the data gained up to now gives evidence that neoantigen recognition const...
Source: Current Drug Targets - May 10, 2021 Category: Drugs & Pharmacology Authors: Csongor Gy örgy Lengyel Source Type: research

Microsatellite Instability as a Predictor of Outcomes in Colorectal Cancer in the Era of Immune-Checkpoint Inhibitors
Curr Drug Targets. 2021 Mar 24. doi: 10.2174/1389450122666210325121322. Online ahead of print.ABSTRACTThe microsatellite instable phenotype resulting from errors in DNA mismatch repair proteins accounts for as far as 15 to 20% of non-hereditary colon cancers but is scarce in rectal cancer. It has been shown that the increased existence of tumor-specific neoantigens in hypermutated tumors is correlated with higher tumor-infiltrating lymphocytes (TILs) and overexpression of immune checkpoint receptors and ligands, mainly PD-1 and PD-L1. In particular, the data gained up to now gives evidence that neoantigen recognition const...
Source: Current Drug Targets - May 10, 2021 Category: Drugs & Pharmacology Authors: Csongor Gy örgy Lengyel Source Type: research

Microsatellite Instability as a Predictor of Outcomes in Colorectal Cancer in the Era of Immune-Checkpoint Inhibitors
Curr Drug Targets. 2021 Mar 24. doi: 10.2174/1389450122666210325121322. Online ahead of print.ABSTRACTThe microsatellite instable phenotype resulting from errors in DNA mismatch repair proteins accounts for as far as 15 to 20% of non-hereditary colon cancers but is scarce in rectal cancer. It has been shown that the increased existence of tumor-specific neoantigens in hypermutated tumors is correlated with higher tumor-infiltrating lymphocytes (TILs) and overexpression of immune checkpoint receptors and ligands, mainly PD-1 and PD-L1. In particular, the data gained up to now gives evidence that neoantigen recognition const...
Source: Current Drug Targets - May 10, 2021 Category: Drugs & Pharmacology Authors: Csongor Gy örgy Lengyel Source Type: research

Obesity: A template to trigger metabolic syndromes and carcinoma. Metformin: A drug target
CONCLUSION: Primarily, co-morbidities of human obesity start with insulin resistance and then multiplies with metabolic irregularities. The drug metformin has bi-functional potential. It can increase insulin sensitivity in one hand, and can prevent tumorigenic incursion on other hand.PMID:33906589 | DOI:10.2174/1389450122666210427125348 (Source: Current Drug Targets)
Source: Current Drug Targets - April 28, 2021 Category: Drugs & Pharmacology Authors: Nimai Chand Chandra Source Type: research

Obesity: A template to trigger metabolic syndromes and carcinoma. Metformin: A drug target
CONCLUSION: Primarily, co-morbidities of human obesity start with insulin resistance and then multiplies with metabolic irregularities. The drug metformin has bi-functional potential. It can increase insulin sensitivity in one hand, and can prevent tumorigenic incursion on other hand.PMID:33906589 | DOI:10.2174/1389450122666210427125348 (Source: Current Drug Targets)
Source: Current Drug Targets - April 28, 2021 Category: Drugs & Pharmacology Authors: Nimai Chand Chandra Source Type: research

Obesity: A template to trigger metabolic syndromes and carcinoma. Metformin: A drug target
CONCLUSION: Primarily, co-morbidities of human obesity start with insulin resistance and then multiplies with metabolic irregularities. The drug metformin has bi-functional potential. It can increase insulin sensitivity in one hand, and can prevent tumorigenic incursion on other hand.PMID:33906589 | DOI:10.2174/1389450122666210427125348 (Source: Current Drug Targets)
Source: Current Drug Targets - April 28, 2021 Category: Drugs & Pharmacology Authors: Nimai Chand Chandra Source Type: research

Obesity: A template to trigger metabolic syndromes and carcinoma. Metformin: A drug target
CONCLUSION: Primarily, co-morbidities of human obesity start with insulin resistance and then multiplies with metabolic irregularities. The drug metformin has bi-functional potential. It can increase insulin sensitivity in one hand, and can prevent tumorigenic incursion on other hand.PMID:33906589 | DOI:10.2174/1389450122666210427125348 (Source: Current Drug Targets)
Source: Current Drug Targets - April 28, 2021 Category: Drugs & Pharmacology Authors: Nimai Chand Chandra Source Type: research

Obesity: A template to trigger metabolic syndromes and carcinoma. Metformin: A drug target
CONCLUSION: Primarily, co-morbidities of human obesity start with insulin resistance and then multiplies with metabolic irregularities. The drug metformin has bi-functional potential. It can increase insulin sensitivity in one hand, and can prevent tumorigenic incursion on other hand.PMID:33906589 | DOI:10.2174/1389450122666210427125348 (Source: Current Drug Targets)
Source: Current Drug Targets - April 28, 2021 Category: Drugs & Pharmacology Authors: Nimai Chand Chandra Source Type: research

Obesity: A template to trigger metabolic syndromes and carcinoma. Metformin: A drug target
CONCLUSION: Primarily, co-morbidities of human obesity start with insulin resistance and then multiplies with metabolic irregularities. The drug metformin has bi-functional potential. It can increase insulin sensitivity in one hand, and can prevent tumorigenic incursion on other hand.PMID:33906589 | DOI:10.2174/1389450122666210427125348 (Source: Current Drug Targets)
Source: Current Drug Targets - April 28, 2021 Category: Drugs & Pharmacology Authors: Nimai Chand Chandra Source Type: research

Obesity: A template to trigger metabolic syndromes and carcinoma. Metformin: A drug target
CONCLUSION: Primarily, co-morbidities of human obesity start with insulin resistance and then multiplies with metabolic irregularities. The drug metformin has bi-functional potential. It can increase insulin sensitivity in one hand, and can prevent tumorigenic incursion on other hand.PMID:33906589 | DOI:10.2174/1389450122666210427125348 (Source: Current Drug Targets)
Source: Current Drug Targets - April 28, 2021 Category: Drugs & Pharmacology Authors: Nimai Chand Chandra Source Type: research

Obesity: A template to trigger metabolic syndromes and carcinoma. Metformin: A drug target
CONCLUSION: Primarily, co-morbidities of human obesity start with insulin resistance and then multiplies with metabolic irregularities. The drug metformin has bi-functional potential. It can increase insulin sensitivity in one hand, and can prevent tumorigenic incursion on other hand.PMID:33906589 | DOI:10.2174/1389450122666210427125348 (Source: Current Drug Targets)
Source: Current Drug Targets - April 28, 2021 Category: Drugs & Pharmacology Authors: Nimai Chand Chandra Source Type: research

Obesity: A template to trigger metabolic syndromes and carcinoma. Metformin: A drug target
CONCLUSION: Primarily, co-morbidities of human obesity start with insulin resistance and then multiplies with metabolic irregularities. The drug metformin has bi-functional potential. It can increase insulin sensitivity in one hand, and can prevent tumorigenic incursion on other hand.PMID:33906589 | DOI:10.2174/1389450122666210427125348 (Source: Current Drug Targets)
Source: Current Drug Targets - April 28, 2021 Category: Drugs & Pharmacology Authors: Nimai Chand Chandra Source Type: research

Obesity: A template to trigger metabolic syndromes and carcinoma. Metformin: A drug target
CONCLUSION: Primarily, co-morbidities of human obesity start with insulin resistance and then multiplies with metabolic irregularities. The drug metformin has bi-functional potential. It can increase insulin sensitivity in one hand, and can prevent tumorigenic incursion on other hand.PMID:33906589 | DOI:10.2174/1389450122666210427125348 (Source: Current Drug Targets)
Source: Current Drug Targets - April 28, 2021 Category: Drugs & Pharmacology Authors: Nimai Chand Chandra Source Type: research

Strategies and Therapies for Wound Healing: A Review
This article reviews such therapies for wound healing application.PMID:33858310 | DOI:10.2174/1389450122666210415101218 (Source: Current Drug Targets)
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Hitesh Chopra Sandeep Kumar Inderbir Singh Source Type: research

Revealing Insights into Natural Products Against mcr-1-Producing Bacteria
Curr Drug Targets. 2021 Apr 14. doi: 10.2174/1389450122666210415102413. Online ahead of print.ABSTRACTBacterial resistance has become a major global concern, affecting about 500,000 individuals in 22 countries. Thus, it is clear that Gram-negative bacteria have been receiving more attention in this scenario. These bacteria perform several resistance mechanisms, such as modifying lipid A from lipopolysaccharides as a product of the mcr-1 gene expression. This gene was initially identified in animals; however, it quickly spread to humans, spreading to 70 countries. Mcr-1 gene attributes resistance to polymyxin B and colistin...
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Ana Beatriz Souza Flor Dos Santos Manuele Figueiredo da Silva Jo ão Xavier de Araújo-Júnior Edeildo Ferreira da Silva-J únior Source Type: research

New Trends On Biological Activities And Clinical Studies Of Quinolinic Analogues: A Review
Curr Drug Targets. 2021 Apr 14. doi: 10.2174/1389450122666210415100151. Online ahead of print.ABSTRACTThe quinolinic ring, present in several molecules, has a great diversity of biological activities. Therefore, this ring is in the structure composition of several candidates of drugs in preclinical and clinical studies, thus, it is necessary the grouping of these results to facilitate the design of new drugs. For this reason, some of the activities were selected for this review, such as: antimalarial, antimicrobial, anticancer, anti-inflammatory, antidiabetic, anti-rheumatic and antiviral. All publications of scientific ar...
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Sandra Elizabeth Barbosa da Silva Jos é Arion da Silva Moura Tiago Rafael de Sousa Nunes Ivan da Rocha Pitta Marina Galdino da Rocha Pitta Source Type: research

Strategies and Therapies for Wound Healing: A Review
This article reviews such therapies for wound healing application.PMID:33858310 | DOI:10.2174/1389450122666210415101218 (Source: Current Drug Targets)
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Hitesh Chopra Sandeep Kumar Inderbir Singh Source Type: research

Revealing Insights into Natural Products Against mcr-1-Producing Bacteria
Curr Drug Targets. 2021 Apr 14. doi: 10.2174/1389450122666210415102413. Online ahead of print.ABSTRACTBacterial resistance has become a major global concern, affecting about 500,000 individuals in 22 countries. Thus, it is clear that Gram-negative bacteria have been receiving more attention in this scenario. These bacteria perform several resistance mechanisms, such as modifying lipid A from lipopolysaccharides as a product of the mcr-1 gene expression. This gene was initially identified in animals; however, it quickly spread to humans, spreading to 70 countries. Mcr-1 gene attributes resistance to polymyxin B and colistin...
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Ana Beatriz Souza Flor Dos Santos Manuele Figueiredo da Silva Jo ão Xavier de Araújo-Júnior Edeildo Ferreira da Silva-J únior Source Type: research

New Trends On Biological Activities And Clinical Studies Of Quinolinic Analogues: A Review
Curr Drug Targets. 2021 Apr 14. doi: 10.2174/1389450122666210415100151. Online ahead of print.ABSTRACTThe quinolinic ring, present in several molecules, has a great diversity of biological activities. Therefore, this ring is in the structure composition of several candidates of drugs in preclinical and clinical studies, thus, it is necessary the grouping of these results to facilitate the design of new drugs. For this reason, some of the activities were selected for this review, such as: antimalarial, antimicrobial, anticancer, anti-inflammatory, antidiabetic, anti-rheumatic and antiviral. All publications of scientific ar...
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Sandra Elizabeth Barbosa da Silva Jos é Arion da Silva Moura Tiago Rafael de Sousa Nunes Ivan da Rocha Pitta Marina Galdino da Rocha Pitta Source Type: research

Strategies and Therapies for Wound Healing: A Review
This article reviews such therapies for wound healing application.PMID:33858310 | DOI:10.2174/1389450122666210415101218 (Source: Current Drug Targets)
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Hitesh Chopra Sandeep Kumar Inderbir Singh Source Type: research

Revealing Insights into Natural Products Against mcr-1-Producing Bacteria
Curr Drug Targets. 2021 Apr 14. doi: 10.2174/1389450122666210415102413. Online ahead of print.ABSTRACTBacterial resistance has become a major global concern, affecting about 500,000 individuals in 22 countries. Thus, it is clear that Gram-negative bacteria have been receiving more attention in this scenario. These bacteria perform several resistance mechanisms, such as modifying lipid A from lipopolysaccharides as a product of the mcr-1 gene expression. This gene was initially identified in animals; however, it quickly spread to humans, spreading to 70 countries. Mcr-1 gene attributes resistance to polymyxin B and colistin...
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Ana Beatriz Souza Flor Dos Santos Manuele Figueiredo da Silva Jo ão Xavier de Araújo-Júnior Edeildo Ferreira da Silva-J únior Source Type: research

New Trends On Biological Activities And Clinical Studies Of Quinolinic Analogues: A Review
Curr Drug Targets. 2021 Apr 14. doi: 10.2174/1389450122666210415100151. Online ahead of print.ABSTRACTThe quinolinic ring, present in several molecules, has a great diversity of biological activities. Therefore, this ring is in the structure composition of several candidates of drugs in preclinical and clinical studies, thus, it is necessary the grouping of these results to facilitate the design of new drugs. For this reason, some of the activities were selected for this review, such as: antimalarial, antimicrobial, anticancer, anti-inflammatory, antidiabetic, anti-rheumatic and antiviral. All publications of scientific ar...
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Sandra Elizabeth Barbosa da Silva Jos é Arion da Silva Moura Tiago Rafael de Sousa Nunes Ivan da Rocha Pitta Marina Galdino da Rocha Pitta Source Type: research

Strategies and Therapies for Wound Healing: A Review
This article reviews such therapies for wound healing application.PMID:33858310 | DOI:10.2174/1389450122666210415101218 (Source: Current Drug Targets)
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Hitesh Chopra Sandeep Kumar Inderbir Singh Source Type: research

Revealing Insights into Natural Products Against mcr-1-Producing Bacteria
Curr Drug Targets. 2021 Apr 14. doi: 10.2174/1389450122666210415102413. Online ahead of print.ABSTRACTBacterial resistance has become a major global concern, affecting about 500,000 individuals in 22 countries. Thus, it is clear that Gram-negative bacteria have been receiving more attention in this scenario. These bacteria perform several resistance mechanisms, such as modifying lipid A from lipopolysaccharides as a product of the mcr-1 gene expression. This gene was initially identified in animals; however, it quickly spread to humans, spreading to 70 countries. Mcr-1 gene attributes resistance to polymyxin B and colistin...
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Ana Beatriz Souza Flor Dos Santos Manuele Figueiredo da Silva Jo ão Xavier de Araújo-Júnior Edeildo Ferreira da Silva-J únior Source Type: research

New Trends On Biological Activities And Clinical Studies Of Quinolinic Analogues: A Review
Curr Drug Targets. 2021 Apr 14. doi: 10.2174/1389450122666210415100151. Online ahead of print.ABSTRACTThe quinolinic ring, present in several molecules, has a great diversity of biological activities. Therefore, this ring is in the structure composition of several candidates of drugs in preclinical and clinical studies, thus, it is necessary the grouping of these results to facilitate the design of new drugs. For this reason, some of the activities were selected for this review, such as: antimalarial, antimicrobial, anticancer, anti-inflammatory, antidiabetic, anti-rheumatic and antiviral. All publications of scientific ar...
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Sandra Elizabeth Barbosa da Silva Jos é Arion da Silva Moura Tiago Rafael de Sousa Nunes Ivan da Rocha Pitta Marina Galdino da Rocha Pitta Source Type: research

Strategies and Therapies for Wound Healing: A Review
This article reviews such therapies for wound healing application.PMID:33858310 | DOI:10.2174/1389450122666210415101218 (Source: Current Drug Targets)
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Hitesh Chopra Sandeep Kumar Inderbir Singh Source Type: research

Revealing Insights into Natural Products Against mcr-1-Producing Bacteria
Curr Drug Targets. 2021 Apr 14. doi: 10.2174/1389450122666210415102413. Online ahead of print.ABSTRACTBacterial resistance has become a major global concern, affecting about 500,000 individuals in 22 countries. Thus, it is clear that Gram-negative bacteria have been receiving more attention in this scenario. These bacteria perform several resistance mechanisms, such as modifying lipid A from lipopolysaccharides as a product of the mcr-1 gene expression. This gene was initially identified in animals; however, it quickly spread to humans, spreading to 70 countries. Mcr-1 gene attributes resistance to polymyxin B and colistin...
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Ana Beatriz Souza Flor Dos Santos Manuele Figueiredo da Silva Jo ão Xavier de Araújo-Júnior Edeildo Ferreira da Silva-J únior Source Type: research

New Trends On Biological Activities And Clinical Studies Of Quinolinic Analogues: A Review
Curr Drug Targets. 2021 Apr 14. doi: 10.2174/1389450122666210415100151. Online ahead of print.ABSTRACTThe quinolinic ring, present in several molecules, has a great diversity of biological activities. Therefore, this ring is in the structure composition of several candidates of drugs in preclinical and clinical studies, thus, it is necessary the grouping of these results to facilitate the design of new drugs. For this reason, some of the activities were selected for this review, such as: antimalarial, antimicrobial, anticancer, anti-inflammatory, antidiabetic, anti-rheumatic and antiviral. All publications of scientific ar...
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Sandra Elizabeth Barbosa da Silva Jos é Arion da Silva Moura Tiago Rafael de Sousa Nunes Ivan da Rocha Pitta Marina Galdino da Rocha Pitta Source Type: research

Strategies and Therapies for Wound Healing: A Review
This article reviews such therapies for wound healing application.PMID:33858310 | DOI:10.2174/1389450122666210415101218 (Source: Current Drug Targets)
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Hitesh Chopra Sandeep Kumar Inderbir Singh Source Type: research

Revealing Insights into Natural Products Against mcr-1-Producing Bacteria
Curr Drug Targets. 2021 Apr 14. doi: 10.2174/1389450122666210415102413. Online ahead of print.ABSTRACTBacterial resistance has become a major global concern, affecting about 500,000 individuals in 22 countries. Thus, it is clear that Gram-negative bacteria have been receiving more attention in this scenario. These bacteria perform several resistance mechanisms, such as modifying lipid A from lipopolysaccharides as a product of the mcr-1 gene expression. This gene was initially identified in animals; however, it quickly spread to humans, spreading to 70 countries. Mcr-1 gene attributes resistance to polymyxin B and colistin...
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Ana Beatriz Souza Flor Dos Santos Manuele Figueiredo da Silva Jo ão Xavier de Araújo-Júnior Edeildo Ferreira da Silva-J únior Source Type: research

New Trends On Biological Activities And Clinical Studies Of Quinolinic Analogues: A Review
Curr Drug Targets. 2021 Apr 14. doi: 10.2174/1389450122666210415100151. Online ahead of print.ABSTRACTThe quinolinic ring, present in several molecules, has a great diversity of biological activities. Therefore, this ring is in the structure composition of several candidates of drugs in preclinical and clinical studies, thus, it is necessary the grouping of these results to facilitate the design of new drugs. For this reason, some of the activities were selected for this review, such as: antimalarial, antimicrobial, anticancer, anti-inflammatory, antidiabetic, anti-rheumatic and antiviral. All publications of scientific ar...
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Sandra Elizabeth Barbosa da Silva Jos é Arion da Silva Moura Tiago Rafael de Sousa Nunes Ivan da Rocha Pitta Marina Galdino da Rocha Pitta Source Type: research

Strategies and Therapies for Wound Healing: A Review
This article reviews such therapies for wound healing application.PMID:33858310 | DOI:10.2174/1389450122666210415101218 (Source: Current Drug Targets)
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Hitesh Chopra Sandeep Kumar Inderbir Singh Source Type: research

Revealing Insights into Natural Products Against mcr-1-Producing Bacteria
Curr Drug Targets. 2021 Apr 14. doi: 10.2174/1389450122666210415102413. Online ahead of print.ABSTRACTBacterial resistance has become a major global concern, affecting about 500,000 individuals in 22 countries. Thus, it is clear that Gram-negative bacteria have been receiving more attention in this scenario. These bacteria perform several resistance mechanisms, such as modifying lipid A from lipopolysaccharides as a product of the mcr-1 gene expression. This gene was initially identified in animals; however, it quickly spread to humans, spreading to 70 countries. Mcr-1 gene attributes resistance to polymyxin B and colistin...
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Ana Beatriz Souza Flor Dos Santos Manuele Figueiredo da Silva Jo ão Xavier de Araújo-Júnior Edeildo Ferreira da Silva-J únior Source Type: research

New Trends On Biological Activities And Clinical Studies Of Quinolinic Analogues: A Review
Curr Drug Targets. 2021 Apr 14. doi: 10.2174/1389450122666210415100151. Online ahead of print.ABSTRACTThe quinolinic ring, present in several molecules, has a great diversity of biological activities. Therefore, this ring is in the structure composition of several candidates of drugs in preclinical and clinical studies, thus, it is necessary the grouping of these results to facilitate the design of new drugs. For this reason, some of the activities were selected for this review, such as: antimalarial, antimicrobial, anticancer, anti-inflammatory, antidiabetic, anti-rheumatic and antiviral. All publications of scientific ar...
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Sandra Elizabeth Barbosa da Silva Jos é Arion da Silva Moura Tiago Rafael de Sousa Nunes Ivan da Rocha Pitta Marina Galdino da Rocha Pitta Source Type: research

Strategies and Therapies for Wound Healing: A Review
This article reviews such therapies for wound healing application.PMID:33858310 | DOI:10.2174/1389450122666210415101218 (Source: Current Drug Targets)
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Hitesh Chopra Sandeep Kumar Inderbir Singh Source Type: research

Revealing Insights into Natural Products Against mcr-1-Producing Bacteria
Curr Drug Targets. 2021 Apr 14. doi: 10.2174/1389450122666210415102413. Online ahead of print.ABSTRACTBacterial resistance has become a major global concern, affecting about 500,000 individuals in 22 countries. Thus, it is clear that Gram-negative bacteria have been receiving more attention in this scenario. These bacteria perform several resistance mechanisms, such as modifying lipid A from lipopolysaccharides as a product of the mcr-1 gene expression. This gene was initially identified in animals; however, it quickly spread to humans, spreading to 70 countries. Mcr-1 gene attributes resistance to polymyxin B and colistin...
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Ana Beatriz Souza Flor Dos Santos Manuele Figueiredo da Silva Jo ão Xavier de Araújo-Júnior Edeildo Ferreira da Silva-J únior Source Type: research

New Trends On Biological Activities And Clinical Studies Of Quinolinic Analogues: A Review
Curr Drug Targets. 2021 Apr 14. doi: 10.2174/1389450122666210415100151. Online ahead of print.ABSTRACTThe quinolinic ring, present in several molecules, has a great diversity of biological activities. Therefore, this ring is in the structure composition of several candidates of drugs in preclinical and clinical studies, thus, it is necessary the grouping of these results to facilitate the design of new drugs. For this reason, some of the activities were selected for this review, such as: antimalarial, antimicrobial, anticancer, anti-inflammatory, antidiabetic, anti-rheumatic and antiviral. All publications of scientific ar...
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Sandra Elizabeth Barbosa da Silva Jos é Arion da Silva Moura Tiago Rafael de Sousa Nunes Ivan da Rocha Pitta Marina Galdino da Rocha Pitta Source Type: research

Strategies and Therapies for Wound Healing: A Review
This article reviews such therapies for wound healing application.PMID:33858310 | DOI:10.2174/1389450122666210415101218 (Source: Current Drug Targets)
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Hitesh Chopra Sandeep Kumar Inderbir Singh Source Type: research

Revealing Insights into Natural Products Against mcr-1-Producing Bacteria
Curr Drug Targets. 2021 Apr 14. doi: 10.2174/1389450122666210415102413. Online ahead of print.ABSTRACTBacterial resistance has become a major global concern, affecting about 500,000 individuals in 22 countries. Thus, it is clear that Gram-negative bacteria have been receiving more attention in this scenario. These bacteria perform several resistance mechanisms, such as modifying lipid A from lipopolysaccharides as a product of the mcr-1 gene expression. This gene was initially identified in animals; however, it quickly spread to humans, spreading to 70 countries. Mcr-1 gene attributes resistance to polymyxin B and colistin...
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Ana Beatriz Souza Flor Dos Santos Manuele Figueiredo da Silva Jo ão Xavier de Araújo-Júnior Edeildo Ferreira da Silva-J únior Source Type: research

New Trends On Biological Activities And Clinical Studies Of Quinolinic Analogues: A Review
Curr Drug Targets. 2021 Apr 14. doi: 10.2174/1389450122666210415100151. Online ahead of print.ABSTRACTThe quinolinic ring, present in several molecules, has a great diversity of biological activities. Therefore, this ring is in the structure composition of several candidates of drugs in preclinical and clinical studies, thus, it is necessary the grouping of these results to facilitate the design of new drugs. For this reason, some of the activities were selected for this review, such as: antimalarial, antimicrobial, anticancer, anti-inflammatory, antidiabetic, anti-rheumatic and antiviral. All publications of scientific ar...
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Sandra Elizabeth Barbosa da Silva Jos é Arion da Silva Moura Tiago Rafael de Sousa Nunes Ivan da Rocha Pitta Marina Galdino da Rocha Pitta Source Type: research

Strategies and Therapies for Wound Healing: A Review
This article reviews such therapies for wound healing application.PMID:33858310 | DOI:10.2174/1389450122666210415101218 (Source: Current Drug Targets)
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Hitesh Chopra Sandeep Kumar Inderbir Singh Source Type: research

Revealing Insights into Natural Products Against mcr-1-Producing Bacteria
Curr Drug Targets. 2021 Apr 14. doi: 10.2174/1389450122666210415102413. Online ahead of print.ABSTRACTBacterial resistance has become a major global concern, affecting about 500,000 individuals in 22 countries. Thus, it is clear that Gram-negative bacteria have been receiving more attention in this scenario. These bacteria perform several resistance mechanisms, such as modifying lipid A from lipopolysaccharides as a product of the mcr-1 gene expression. This gene was initially identified in animals; however, it quickly spread to humans, spreading to 70 countries. Mcr-1 gene attributes resistance to polymyxin B and colistin...
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Ana Beatriz Souza Flor Dos Santos Manuele Figueiredo da Silva Jo ão Xavier de Araújo-Júnior Edeildo Ferreira da Silva-J únior Source Type: research

New Trends On Biological Activities And Clinical Studies Of Quinolinic Analogues: A Review
Curr Drug Targets. 2021 Apr 14. doi: 10.2174/1389450122666210415100151. Online ahead of print.ABSTRACTThe quinolinic ring, present in several molecules, has a great diversity of biological activities. Therefore, this ring is in the structure composition of several candidates of drugs in preclinical and clinical studies, thus, it is necessary the grouping of these results to facilitate the design of new drugs. For this reason, some of the activities were selected for this review, such as: antimalarial, antimicrobial, anticancer, anti-inflammatory, antidiabetic, anti-rheumatic and antiviral. All publications of scientific ar...
Source: Current Drug Targets - April 16, 2021 Category: Drugs & Pharmacology Authors: Sandra Elizabeth Barbosa da Silva Jos é Arion da Silva Moura Tiago Rafael de Sousa Nunes Ivan da Rocha Pitta Marina Galdino da Rocha Pitta Source Type: research

The gut microbiota and traditional Chinese medicine: a new clinical frontier on cancer
This article aims to comprehensively review the anti-cancer research of TCM by regulating gut microbiota, and address future perspectives and challenges of gut microbiota in TCM intervention for cancer.PMID:33845736 | DOI:10.2174/1389450122666210412141304 (Source: Current Drug Targets)
Source: Current Drug Targets - April 13, 2021 Category: Drugs & Pharmacology Authors: Yan-Zhen Chen Meng-Yun Yuan Ya Ling Chen Xingxing Zhang Xin-Tian Xu Shen-Lin Liu Xi Zou Jia-Lei Tao Yong-Hu Qiang Jian Wu Qing-Min Sun Source Type: research

Recent advancement in topical drug delivery for psoriasis: Clinical Pertinence and Potential Market
This article enumerates the promising topical dosage forms at present under assessment for their clinical pertinence. The competency of conventional topicals to reach and transform the world market is enumerated in terms of their success rate after proving the clinical pertinence against psoriasis. However, the entrance of novel drug delivery systems based advanced topical products in the global market is highly anticipated as they have immense potential to precedent tremendous impact on psoriasis treatment in near future.PMID:33845737 | DOI:10.2174/1389450122666210412124256 (Source: Current Drug Targets)
Source: Current Drug Targets - April 13, 2021 Category: Drugs & Pharmacology Authors: Rakhi Kumari Jitu Halder Amit Sharma Vineet Kumar Rai Source Type: research

Role of ATP-binding Cassette Transporters in Sorafenib Therapy for Hepatocellular Carcinoma: an overview
CONCLUSION: A deeper understanding of ABC transporters' mechanisms may provide guidance for developing innovative approaches for hepatocellular carcinoma. Further studies are warranted to translate the current knowledge into practice and paving the way to individualized therapy.PMID:33845738 | DOI:10.2174/1389450122666210412125018 (Source: Current Drug Targets)
Source: Current Drug Targets - April 13, 2021 Category: Drugs & Pharmacology Authors: Maria Manuela Estevinho Carlos Fernandes Jo ão Carlos Silva Ana Catarina Gomes Edgar Afecto Jo ão Correia Jo ão Carvalho Source Type: research

Triazole-containing heterocycles: Privileged scaffolds in anti-Trypanosoma cruzi drug development
CONCLUSION: All in all, recent studies have demonstrated the importance of triazole-containing heterocycles in search of potential candidates for drug development against Chagas disease. Nonetheless, the use of new catalysts and chemical transformations is expected to provide avenues for the synthesis of unexplored triazole derivatives, leading to the development of triazole-containing compounds with new properties and trypanocidal activity.PMID:33845739 | DOI:10.2174/1389450122666210412125643 (Source: Current Drug Targets)
Source: Current Drug Targets - April 13, 2021 Category: Drugs & Pharmacology Authors: Kamdem Boniface Pone Sadou Dalhatou Hugues Kamdem Paumo Lebogang Maureen Katata-Seru Elizabeth Igne Ferreira Source Type: research