Common Clinical Features of Cases with Mpox Reinfection
Curr Drug Targets. 2023 Nov 8. doi: 10.2174/0113894501267823231103103344. Online ahead of print.NO ABSTRACTPMID:37946355 | DOI:10.2174/0113894501267823231103103344 (Source: Current Drug Targets)
Source: Current Drug Targets - November 10, 2023 Category: Drugs & Pharmacology Authors: Masoud Keikha Mohammad Abavisani Amirhossein Sahebkar Source Type: research

N-Heterocycle based Degraders (PROTACs) Manifesting Anticancer Efficacy: Recent Advances
Curr Drug Targets. 2023 Nov 8. doi: 10.2174/0113894501273969231102095615. Online ahead of print.ABSTRACTProteolysis Targeting Chimeras (PROTACs) technology has emerged as a promising strategy for the treatment of undruggable therapeutic targets. Researchers have invested a great effort in developing druggable PROTACs; however, the problems associated with PROTACs, including poor solubility, metabolic stability, cell permeability, and pharmacokinetic profile, restrict their clinical utility. Thus, there is a pressing need to expand the size of the armory of PROTACs which will escalate the chances of pinpointing new PROTACs ...
Source: Current Drug Targets - November 10, 2023 Category: Drugs & Pharmacology Authors: Suddhasatwa Banerjee Sachin Sharma Amandeep Thakur Ritika Sachdeva Ram Sharma Kunal Nepali Jing Ping Liou Source Type: research

NLRP3: A Promising Therapeutic Target for Inflammatory Bowel Disease
Curr Drug Targets. 2023 Nov 8. doi: 10.2174/0113894501255960231101105113. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is an intestinal disease with complicated pathological mechanisms. The incidence of IBD has been increasing in recent years, which has a significant negative impact on the lives of patients. Therefore, it is particularly important to find new therapeutic targets and innovative drugs for the development of IBD. Recent studies have revealed that NLRP3 inflammatory vesicles can play an important role in maintaining intestinal homeostasi...
Source: Current Drug Targets - November 10, 2023 Category: Drugs & Pharmacology Authors: Jiayu Zhang Shuyan Zeng Peng Wang Youxiang Chen Chunyan Zeng Source Type: research

Common Clinical Features of Cases with Mpox Reinfection
Curr Drug Targets. 2023 Nov 8. doi: 10.2174/0113894501267823231103103344. Online ahead of print.NO ABSTRACTPMID:37946355 | DOI:10.2174/0113894501267823231103103344 (Source: Current Drug Targets)
Source: Current Drug Targets - November 10, 2023 Category: Drugs & Pharmacology Authors: Masoud Keikha Mohammad Abavisani Amirhossein Sahebkar Source Type: research

Crucial Role of microRNAs as New Targets for Amelogenesis Disorders Detection
CONCLUSION: Liquid biopsy approaches are a promising way to reduce the economic cost of treatment for these patients in modern healthcare. Unique data exist about the role of microRNA in regulating amelogenesis. The list of microRNAs that are associated with AI genes and classified by AI types has been uncovered. The target gene analysis showed the variety of functions of selected microRNAs, which explains the multiple heterogeneous mechanisms in amelogenesis. Predisposition to mineralisation problems is a programmed event. Many factors determine the manifestation of this problem. Additionally, it is necessary to remember ...
Source: Current Drug Targets - November 8, 2023 Category: Drugs & Pharmacology Authors: Nadezhda Masunova Maria Tereschenko Georgy Alexandrov Liudmila Spirina Natalia Tarasenko Source Type: research

Crucial Role of microRNAs as New Targets for Amelogenesis Disorders Detection
CONCLUSION: Liquid biopsy approaches are a promising way to reduce the economic cost of treatment for these patients in modern healthcare. Unique data exist about the role of microRNA in regulating amelogenesis. The list of microRNAs that are associated with AI genes and classified by AI types has been uncovered. The target gene analysis showed the variety of functions of selected microRNAs, which explains the multiple heterogeneous mechanisms in amelogenesis. Predisposition to mineralisation problems is a programmed event. Many factors determine the manifestation of this problem. Additionally, it is necessary to remember ...
Source: Current Drug Targets - November 8, 2023 Category: Drugs & Pharmacology Authors: Nadezhda Masunova Maria Tereschenko Georgy Alexandrov Liudmila Spirina Natalia Tarasenko Source Type: research

Targeting Lysyl Oxidase as a Potential Therapeutic Approach to Reducing Fibrotic Scars Post-operatively: Its Biological Role in Post-Surgical Scar Development
Curr Drug Targets. 2023 Oct 27. doi: 10.2174/0113894501249450231023112949. Online ahead of print.ABSTRACTAbdominal and pelvic surgery, or any surgical injury of the peritoneum, often leads to chronic abdominal adhesions that may lead to bowel obstruction, infertility, and pain. Current therapeutic strategies are usually ineffective, and the pathological mechanisms of the disease are unclear. Excess collagen cross-linking is a key mediator for extra-cellular matrix deposition and fibrogenesis. Lysyl oxidase is a key enzyme that catalyzes the formation of stabilizing cross-links in collagen. Dysregulation of Lysyl oxidase (L...
Source: Current Drug Targets - November 6, 2023 Category: Drugs & Pharmacology Authors: Mahin Ghorban Sabbagh Mohsen Aliakbarian Rosita Khodashahi Gordon-A Ferns Hoda Rahimi Kiarash Ashrafzadeh Mahmoud Tavakkoli Mohammad-Hassan Arjmand Source Type: research

Targeting Lysyl Oxidase as a Potential Therapeutic Approach to Reducing Fibrotic Scars Post-operatively: Its Biological Role in Post-Surgical Scar Development
Curr Drug Targets. 2023 Oct 27. doi: 10.2174/0113894501249450231023112949. Online ahead of print.ABSTRACTAbdominal and pelvic surgery, or any surgical injury of the peritoneum, often leads to chronic abdominal adhesions that may lead to bowel obstruction, infertility, and pain. Current therapeutic strategies are usually ineffective, and the pathological mechanisms of the disease are unclear. Excess collagen cross-linking is a key mediator for extra-cellular matrix deposition and fibrogenesis. Lysyl oxidase is a key enzyme that catalyzes the formation of stabilizing cross-links in collagen. Dysregulation of Lysyl oxidase (L...
Source: Current Drug Targets - November 6, 2023 Category: Drugs & Pharmacology Authors: Mahin Ghorban Sabbagh Mohsen Aliakbarian Rosita Khodashahi Gordon-A Ferns Hoda Rahimi Kiarash Ashrafzadeh Mahmoud Tavakkoli Mohammad-Hassan Arjmand Source Type: research

An Insight into Hepatitis C Virus: In Search of Promising Drug Targets
Curr Drug Targets. 2023 Oct 27. doi: 10.2174/0113894501265769231020031857. Online ahead of print.ABSTRACTHepatitis C Virus (HCV) is a global health concern, chronically infecting over 70 million people worldwide. HCV is a bloodborne pathogen that primarily affects the liver, and chronic HCV infection can lead to cirrhosis, liver cancer, and liver failure over time. There is an urgent need for more effective approaches to prevent and treat HCV. This review summarizes current knowledge on the virology, transmission, diagnosis, and management of HCV infection. It also provides an in-depth analysis of HCV proteins as promising...
Source: Current Drug Targets - November 1, 2023 Category: Drugs & Pharmacology Authors: Aditya Dwivedi Manish Dwivedi Source Type: research

An Insight into Hepatitis C Virus: In Search of Promising Drug Targets
Curr Drug Targets. 2023 Oct 27. doi: 10.2174/0113894501265769231020031857. Online ahead of print.ABSTRACTHepatitis C Virus (HCV) is a global health concern, chronically infecting over 70 million people worldwide. HCV is a bloodborne pathogen that primarily affects the liver, and chronic HCV infection can lead to cirrhosis, liver cancer, and liver failure over time. There is an urgent need for more effective approaches to prevent and treat HCV. This review summarizes current knowledge on the virology, transmission, diagnosis, and management of HCV infection. It also provides an in-depth analysis of HCV proteins as promising...
Source: Current Drug Targets - November 1, 2023 Category: Drugs & Pharmacology Authors: Aditya Dwivedi Manish Dwivedi Source Type: research

An Insight into Hepatitis C Virus: In Search of Promising Drug Targets
Curr Drug Targets. 2023 Oct 27. doi: 10.2174/0113894501265769231020031857. Online ahead of print.ABSTRACTHepatitis C Virus (HCV) is a global health concern, chronically infecting over 70 million people worldwide. HCV is a bloodborne pathogen that primarily affects the liver, and chronic HCV infection can lead to cirrhosis, liver cancer, and liver failure over time. There is an urgent need for more effective approaches to prevent and treat HCV. This review summarizes current knowledge on the virology, transmission, diagnosis, and management of HCV infection. It also provides an in-depth analysis of HCV proteins as promising...
Source: Current Drug Targets - November 1, 2023 Category: Drugs & Pharmacology Authors: Aditya Dwivedi Manish Dwivedi Source Type: research

An Insight into Hepatitis C Virus: In Search of Promising Drug Targets
Curr Drug Targets. 2023 Oct 27. doi: 10.2174/0113894501265769231020031857. Online ahead of print.ABSTRACTHepatitis C Virus (HCV) is a global health concern, chronically infecting over 70 million people worldwide. HCV is a bloodborne pathogen that primarily affects the liver, and chronic HCV infection can lead to cirrhosis, liver cancer, and liver failure over time. There is an urgent need for more effective approaches to prevent and treat HCV. This review summarizes current knowledge on the virology, transmission, diagnosis, and management of HCV infection. It also provides an in-depth analysis of HCV proteins as promising...
Source: Current Drug Targets - November 1, 2023 Category: Drugs & Pharmacology Authors: Aditya Dwivedi Manish Dwivedi Source Type: research

An Insight into Hepatitis C Virus: In Search of Promising Drug Targets
Curr Drug Targets. 2023 Oct 27. doi: 10.2174/0113894501265769231020031857. Online ahead of print.ABSTRACTHepatitis C Virus (HCV) is a global health concern, chronically infecting over 70 million people worldwide. HCV is a bloodborne pathogen that primarily affects the liver, and chronic HCV infection can lead to cirrhosis, liver cancer, and liver failure over time. There is an urgent need for more effective approaches to prevent and treat HCV. This review summarizes current knowledge on the virology, transmission, diagnosis, and management of HCV infection. It also provides an in-depth analysis of HCV proteins as promising...
Source: Current Drug Targets - November 1, 2023 Category: Drugs & Pharmacology Authors: Aditya Dwivedi Manish Dwivedi Source Type: research

SGK-1 Signalling Pathway is a Key Factor in Cell Survival in Ischemic Injury
Curr Drug Targets. 2023 Oct 22. doi: 10.2174/0113894501239948231013072901. Online ahead of print.ABSTRACTSerum and glucocorticoid-regulated kinases (SGK) are serine/threonine kinases that belong to AGC. The SGK-1, which responds to stress, controls a range of ion channels, cell growth, transcription factors, membrane transporters, cellular enzymes, cell survival, proliferation and death. Its expression is highly controlled by various factors such as hyperosmotic or isotonic oxidative stress, cell shrinkage, radiation, high blood sugar, neuronal injury, DNA damage, mechanical stress, thermal shock, excitement, dehydration a...
Source: Current Drug Targets - October 31, 2023 Category: Drugs & Pharmacology Authors: Manisha Chaudhary Veerta Sharma Onkar Bedi Amarjot Kaur Thakur Gurjeet Singh Source Type: research

SGK-1 Signalling Pathway is a Key Factor in Cell Survival in Ischemic Injury
Curr Drug Targets. 2023 Oct 22. doi: 10.2174/0113894501239948231013072901. Online ahead of print.ABSTRACTSerum and glucocorticoid-regulated kinases (SGK) are serine/threonine kinases that belong to AGC. The SGK-1, which responds to stress, controls a range of ion channels, cell growth, transcription factors, membrane transporters, cellular enzymes, cell survival, proliferation and death. Its expression is highly controlled by various factors such as hyperosmotic or isotonic oxidative stress, cell shrinkage, radiation, high blood sugar, neuronal injury, DNA damage, mechanical stress, thermal shock, excitement, dehydration a...
Source: Current Drug Targets - October 31, 2023 Category: Drugs & Pharmacology Authors: Manisha Chaudhary Veerta Sharma Onkar Bedi Amarjot Kaur Thakur Gurjeet Singh Source Type: research