The Role of Host-Cellular Responses in COVID-19 Endothelial Dysfunction
Curr Drug Targets. 2022 Jun 24. doi: 10.2174/1389450123666220624094940. Online ahead of print.ABSTRACTSARS-CoV2, Severe acute respiratory syndrome coronavirus 2, is a novel member of the human 30 coronavirus family that has recently emerged worldwide to cause COVID-19 disease. COVID-19 disease has been declared a worldwide pandemic with over 270 million total cases, and >5 million deaths as of this writing. Although co-morbidities and preexisting conditions have played a significant role in the severity of COVID-19, the hallmark feature of severe disease associated with SARS-CoV2 is respiratory failure. Recent findings ...
Source: Current Drug Targets - June 24, 2022 Category: Drugs & Pharmacology Authors: Thomas E Moran Daniel E Hammers Shaun W Lee Source Type: research

Cellular Therapeutics for Chronic Wound healing: Future for Regenerative Medicine
Curr Drug Targets. 2022 Jun 23. doi: 10.2174/138945012309220623144620. Online ahead of print.ABSTRACTChronic wounds are associated with significant morbidity and mortality which demands long-term effective treatment and represents a tremendous financial strain on the global healthcare systems. Regenerative medicines using stem cells have recently become apparent as a promising approach and are an active zone of investigations they hold the potential to differentiate into specific types of cells and thus possess self-renewable, regenerative, and immune-modulatory effects. Furthermore, with the rise of technology various cel...
Source: Current Drug Targets - June 24, 2022 Category: Drugs & Pharmacology Authors: Preety Sharma Arun Kumar Asmita Deka Dey Source Type: research

Therapeutic approaches for combating Aspergillus associated infection
Curr Drug Targets. 2022 Jun 23. doi: 10.2174/1389450123666220623164548. Online ahead of print.ABSTRACTNowadays fungal infection emerged as a significant problem to healthcare management systems due to the high frequency of associated morbidity and mortality and the limitations like toxicity, drug-drug interactions, and resistance of the currently available antifungal agents. Aspergillus is the most common mold which causes infection in immunocompromised hosts. It is a hyaline mold that is cosmopolitan and ubiquitous. Aspergillus infects around 10 million population each year with a mortality rate of 30-90%. Clinically avai...
Source: Current Drug Targets - June 24, 2022 Category: Drugs & Pharmacology Authors: Aruna Punia Pooja Choudhary Namita Sharma Sweety Dahiya Prity Gulia Anil K Chhillar Source Type: research

The Role of Host-Cellular Responses in COVID-19 Endothelial Dysfunction
Curr Drug Targets. 2022 Jun 24. doi: 10.2174/1389450123666220624094940. Online ahead of print.ABSTRACTSARS-CoV2, Severe acute respiratory syndrome coronavirus 2, is a novel member of the human 30 coronavirus family that has recently emerged worldwide to cause COVID-19 disease. COVID-19 disease has been declared a worldwide pandemic with over 270 million total cases, and >5 million deaths as of this writing. Although co-morbidities and preexisting conditions have played a significant role in the severity of COVID-19, the hallmark feature of severe disease associated with SARS-CoV2 is respiratory failure. Recent findings ...
Source: Current Drug Targets - June 24, 2022 Category: Drugs & Pharmacology Authors: Thomas E Moran Daniel E Hammers Shaun W Lee Source Type: research

Cellular Therapeutics for Chronic Wound healing: Future for Regenerative Medicine
Curr Drug Targets. 2022 Jun 23. doi: 10.2174/138945012309220623144620. Online ahead of print.ABSTRACTChronic wounds are associated with significant morbidity and mortality which demands long-term effective treatment and represents a tremendous financial strain on the global healthcare systems. Regenerative medicines using stem cells have recently become apparent as a promising approach and are an active zone of investigations they hold the potential to differentiate into specific types of cells and thus possess self-renewable, regenerative, and immune-modulatory effects. Furthermore, with the rise of technology various cel...
Source: Current Drug Targets - June 24, 2022 Category: Drugs & Pharmacology Authors: Preety Sharma Arun Kumar Asmita Deka Dey Source Type: research

Therapeutic approaches for combating Aspergillus associated infection
Curr Drug Targets. 2022 Jun 23. doi: 10.2174/1389450123666220623164548. Online ahead of print.ABSTRACTNowadays fungal infection emerged as a significant problem to healthcare management systems due to the high frequency of associated morbidity and mortality and the limitations like toxicity, drug-drug interactions, and resistance of the currently available antifungal agents. Aspergillus is the most common mold which causes infection in immunocompromised hosts. It is a hyaline mold that is cosmopolitan and ubiquitous. Aspergillus infects around 10 million population each year with a mortality rate of 30-90%. Clinically avai...
Source: Current Drug Targets - June 24, 2022 Category: Drugs & Pharmacology Authors: Aruna Punia Pooja Choudhary Namita Sharma Sweety Dahiya Prity Gulia Anil K Chhillar Source Type: research

The Role of Host-Cellular Responses in COVID-19 Endothelial Dysfunction
Curr Drug Targets. 2022 Jun 24. doi: 10.2174/1389450123666220624094940. Online ahead of print.ABSTRACTSARS-CoV2, Severe acute respiratory syndrome coronavirus 2, is a novel member of the human 30 coronavirus family that has recently emerged worldwide to cause COVID-19 disease. COVID-19 disease has been declared a worldwide pandemic with over 270 million total cases, and >5 million deaths as of this writing. Although co-morbidities and preexisting conditions have played a significant role in the severity of COVID-19, the hallmark feature of severe disease associated with SARS-CoV2 is respiratory failure. Recent findings ...
Source: Current Drug Targets - June 24, 2022 Category: Drugs & Pharmacology Authors: Thomas E Moran Daniel E Hammers Shaun W Lee Source Type: research

Cellular Therapeutics for Chronic Wound healing: Future for Regenerative Medicine
Curr Drug Targets. 2022 Jun 23. doi: 10.2174/138945012309220623144620. Online ahead of print.ABSTRACTChronic wounds are associated with significant morbidity and mortality which demands long-term effective treatment and represents a tremendous financial strain on the global healthcare systems. Regenerative medicines using stem cells have recently become apparent as a promising approach and are an active zone of investigations they hold the potential to differentiate into specific types of cells and thus possess self-renewable, regenerative, and immune-modulatory effects. Furthermore, with the rise of technology various cel...
Source: Current Drug Targets - June 24, 2022 Category: Drugs & Pharmacology Authors: Preety Sharma Arun Kumar Asmita Deka Dey Source Type: research

Therapeutic approaches for combating Aspergillus associated infection
Curr Drug Targets. 2022 Jun 23. doi: 10.2174/1389450123666220623164548. Online ahead of print.ABSTRACTNowadays fungal infection emerged as a significant problem to healthcare management systems due to the high frequency of associated morbidity and mortality and the limitations like toxicity, drug-drug interactions, and resistance of the currently available antifungal agents. Aspergillus is the most common mold which causes infection in immunocompromised hosts. It is a hyaline mold that is cosmopolitan and ubiquitous. Aspergillus infects around 10 million population each year with a mortality rate of 30-90%. Clinically avai...
Source: Current Drug Targets - June 24, 2022 Category: Drugs & Pharmacology Authors: Aruna Punia Pooja Choudhary Namita Sharma Sweety Dahiya Prity Gulia Anil K Chhillar Source Type: research

The Role of Host-Cellular Responses in COVID-19 Endothelial Dysfunction
Curr Drug Targets. 2022 Jun 24. doi: 10.2174/1389450123666220624094940. Online ahead of print.ABSTRACTSARS-CoV2, Severe acute respiratory syndrome coronavirus 2, is a novel member of the human 30 coronavirus family that has recently emerged worldwide to cause COVID-19 disease. COVID-19 disease has been declared a worldwide pandemic with over 270 million total cases, and >5 million deaths as of this writing. Although co-morbidities and preexisting conditions have played a significant role in the severity of COVID-19, the hallmark feature of severe disease associated with SARS-CoV2 is respiratory failure. Recent findings ...
Source: Current Drug Targets - June 24, 2022 Category: Drugs & Pharmacology Authors: Thomas E Moran Daniel E Hammers Shaun W Lee Source Type: research

Role and therapeutic potential of RAGE signaling in neurodegeneration
Curr Drug Targets. 2022 Jun 10. doi: 10.2174/1389450123666220610171005. Online ahead of print.ABSTRACTActivation of the receptor for advanced glycation end products (RAGE) has been shown to play an active role in the development of multiple neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Amyotrophic Lateral Sclerosis. Although originally identified as a receptor for advanced glycation end products, RAGE is a pattern recognition receptor able to bind multiple ligands. The final outcome of RAGE signaling is defined in a context and cell type specific manner and can exert both neurotoxic an...
Source: Current Drug Targets - June 15, 2022 Category: Drugs & Pharmacology Authors: Noah Alexander Kinscherf Mariana Pehar Source Type: research

Therapeutic targeting of overexpressed miRNAs in cancer progression
Curr Drug Targets. 2022 Jun 13. doi: 10.2174/1389450123666220613163906. Online ahead of print.ABSTRACTMicroRNAs [miRNAs] are non-coding RNAs involved in the modulation of various biological processes and its dysregulation is greatly associated with cancer progression as miRNAs can act as either tumour suppressors or oncogenes, depending on their intended target, mechanism of actions and expression levels. Thereby, this review paper aims to shed light on the role of overexpressed miRNAs in cancer progression. Cancer cells are known to upregulate specific miRNAs to inhibit the expression of genes regulating cell cycle such a...
Source: Current Drug Targets - June 15, 2022 Category: Drugs & Pharmacology Authors: Sau Har Lee None Brianna Source Type: research

Role and therapeutic potential of RAGE signaling in neurodegeneration
Curr Drug Targets. 2022 Jun 10. doi: 10.2174/1389450123666220610171005. Online ahead of print.ABSTRACTActivation of the receptor for advanced glycation end products (RAGE) has been shown to play an active role in the development of multiple neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Amyotrophic Lateral Sclerosis. Although originally identified as a receptor for advanced glycation end products, RAGE is a pattern recognition receptor able to bind multiple ligands. The final outcome of RAGE signaling is defined in a context and cell type specific manner and can exert both neurotoxic an...
Source: Current Drug Targets - June 15, 2022 Category: Drugs & Pharmacology Authors: Noah Alexander Kinscherf Mariana Pehar Source Type: research

Therapeutic targeting of overexpressed miRNAs in cancer progression
Curr Drug Targets. 2022 Jun 13. doi: 10.2174/1389450123666220613163906. Online ahead of print.ABSTRACTMicroRNAs [miRNAs] are non-coding RNAs involved in the modulation of various biological processes and its dysregulation is greatly associated with cancer progression as miRNAs can act as either tumour suppressors or oncogenes, depending on their intended target, mechanism of actions and expression levels. Thereby, this review paper aims to shed light on the role of overexpressed miRNAs in cancer progression. Cancer cells are known to upregulate specific miRNAs to inhibit the expression of genes regulating cell cycle such a...
Source: Current Drug Targets - June 15, 2022 Category: Drugs & Pharmacology Authors: Sau Har Lee None Brianna Source Type: research

Role and therapeutic potential of RAGE signaling in neurodegeneration
Curr Drug Targets. 2022 Jun 10. doi: 10.2174/1389450123666220610171005. Online ahead of print.ABSTRACTActivation of the receptor for advanced glycation end products (RAGE) has been shown to play an active role in the development of multiple neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Amyotrophic Lateral Sclerosis. Although originally identified as a receptor for advanced glycation end products, RAGE is a pattern recognition receptor able to bind multiple ligands. The final outcome of RAGE signaling is defined in a context and cell type specific manner and can exert both neurotoxic an...
Source: Current Drug Targets - June 15, 2022 Category: Drugs & Pharmacology Authors: Noah Alexander Kinscherf Mariana Pehar Source Type: research