Recent Advances in Biomedical Applications of Mannans and Xylans
Curr Drug Targets. 2024 Feb 19. doi: 10.2174/0113894501285058240203094846. Online ahead of print.ABSTRACTPlant-based phytochemicals, including flavonoids, alkaloids, tannins, saponins, and other metabolites, have attracted considerable attention due to their central role in synthesizing nanomaterials with various biomedical applications. Hemicelluloses are the second most abundant among naturally occurring heteropolymers, accounting for one-third of all plant constituents. In particular, xylans, mannans, and arabinoxylans are structured polysaccharides derived from hemicellulose. Mannans and xylans are characterized by the...
Source: Current Drug Targets - February 20, 2024 Category: Drugs & Pharmacology Authors: Shriya Teli Kajal Deshmukh Tabassum Khan Vasanti Suvarna Source Type: research

Recent Advances in Biomedical Applications of Mannans and Xylans
Curr Drug Targets. 2024 Feb 19. doi: 10.2174/0113894501285058240203094846. Online ahead of print.ABSTRACTPlant-based phytochemicals, including flavonoids, alkaloids, tannins, saponins, and other metabolites, have attracted considerable attention due to their central role in synthesizing nanomaterials with various biomedical applications. Hemicelluloses are the second most abundant among naturally occurring heteropolymers, accounting for one-third of all plant constituents. In particular, xylans, mannans, and arabinoxylans are structured polysaccharides derived from hemicellulose. Mannans and xylans are characterized by the...
Source: Current Drug Targets - February 20, 2024 Category: Drugs & Pharmacology Authors: Shriya Teli Kajal Deshmukh Tabassum Khan Vasanti Suvarna Source Type: research

Quantum Dot-based Bio-conjugates as an Emerging Bioimaging Tool for Cancer Theranostic- A Review
Curr Drug Targets. 2024 Jan 29. doi: 10.2174/0113894501283669240123105250. Online ahead of print.ABSTRACTCancer is the most widely studied disorder in humans, but proper treatment has not yet been developed for it. Conventional therapies, like chemotherapy, radiation therapy, and surgery, have been employed. Such therapies target not only cancerous cells but also harm normal cells. Conventional therapy does not result in specific targeting and hence leads to severe side effects. The main objective of this study is to explore the QDs. QDs are used as nanocarriers for diagnosis and treatment at the same time. They are based ...
Source: Current Drug Targets - January 30, 2024 Category: Drugs & Pharmacology Authors: Lipika Priya Smit Mehta Darshan Gevariya Raghav Sharma Drishti Panjwani Shruti Patel Priyanka Ahlawat Abhay Dharamsi Asha Patel Source Type: research

Quantum Dot-based Bio-conjugates as an Emerging Bioimaging Tool for Cancer Theranostic- A Review
Curr Drug Targets. 2024 Jan 29. doi: 10.2174/0113894501283669240123105250. Online ahead of print.ABSTRACTCancer is the most widely studied disorder in humans, but proper treatment has not yet been developed for it. Conventional therapies, like chemotherapy, radiation therapy, and surgery, have been employed. Such therapies target not only cancerous cells but also harm normal cells. Conventional therapy does not result in specific targeting and hence leads to severe side effects. The main objective of this study is to explore the QDs. QDs are used as nanocarriers for diagnosis and treatment at the same time. They are based ...
Source: Current Drug Targets - January 30, 2024 Category: Drugs & Pharmacology Authors: Lipika Priya Smit Mehta Darshan Gevariya Raghav Sharma Drishti Panjwani Shruti Patel Priyanka Ahlawat Abhay Dharamsi Asha Patel Source Type: research

Quantum Dot-based Bio-conjugates as an Emerging Bioimaging Tool for Cancer Theranostic- A Review
Curr Drug Targets. 2024 Jan 29. doi: 10.2174/0113894501283669240123105250. Online ahead of print.ABSTRACTCancer is the most widely studied disorder in humans, but proper treatment has not yet been developed for it. Conventional therapies, like chemotherapy, radiation therapy, and surgery, have been employed. Such therapies target not only cancerous cells but also harm normal cells. Conventional therapy does not result in specific targeting and hence leads to severe side effects. The main objective of this study is to explore the QDs. QDs are used as nanocarriers for diagnosis and treatment at the same time. They are based ...
Source: Current Drug Targets - January 30, 2024 Category: Drugs & Pharmacology Authors: Lipika Priya Smit Mehta Darshan Gevariya Raghav Sharma Drishti Panjwani Shruti Patel Priyanka Ahlawat Abhay Dharamsi Asha Patel Source Type: research

Quantum Dot-based Bio-conjugates as an Emerging Bioimaging Tool for Cancer Theranostic- A Review
Curr Drug Targets. 2024 Jan 29. doi: 10.2174/0113894501283669240123105250. Online ahead of print.ABSTRACTCancer is the most widely studied disorder in humans, but proper treatment has not yet been developed for it. Conventional therapies, like chemotherapy, radiation therapy, and surgery, have been employed. Such therapies target not only cancerous cells but also harm normal cells. Conventional therapy does not result in specific targeting and hence leads to severe side effects. The main objective of this study is to explore the QDs. QDs are used as nanocarriers for diagnosis and treatment at the same time. They are based ...
Source: Current Drug Targets - January 30, 2024 Category: Drugs & Pharmacology Authors: Lipika Priya Smit Mehta Darshan Gevariya Raghav Sharma Drishti Panjwani Shruti Patel Priyanka Ahlawat Abhay Dharamsi Asha Patel Source Type: research

Quantum Dot-based Bio-conjugates as an Emerging Bioimaging Tool for Cancer Theranostic- A Review
Curr Drug Targets. 2024 Jan 29. doi: 10.2174/0113894501283669240123105250. Online ahead of print.ABSTRACTCancer is the most widely studied disorder in humans, but proper treatment has not yet been developed for it. Conventional therapies, like chemotherapy, radiation therapy, and surgery, have been employed. Such therapies target not only cancerous cells but also harm normal cells. Conventional therapy does not result in specific targeting and hence leads to severe side effects. The main objective of this study is to explore the QDs. QDs are used as nanocarriers for diagnosis and treatment at the same time. They are based ...
Source: Current Drug Targets - January 30, 2024 Category: Drugs & Pharmacology Authors: Lipika Priya Smit Mehta Darshan Gevariya Raghav Sharma Drishti Panjwani Shruti Patel Priyanka Ahlawat Abhay Dharamsi Asha Patel Source Type: research

Deciphering Neuroprotective Effect of Rosmarinus officinalis L. (syn. Salvia rosmarinus Spenn.) through Preclinical and Clinical Studies
Curr Drug Targets. 2024 Jan 22. doi: 10.2174/0113894501255093240117092328. Online ahead of print.ABSTRACTRosmarinus officinalis L. (RO, rosemary) is a well-known medicinal, aromatic, and culinary herb with traditional use in European folk medicine against memory deficits and neurodegenerative disorders. This review highlights the different neuroprotective activities of RO investigated in both preclinical and clinical studies, as well as in silico molecular docking of bioactive compounds found in RO. The neuroprotective effect of RO was searched through databases including PubMed, Web of Science (WoS), Scopus, and Clinical ...
Source: Current Drug Targets - January 23, 2024 Category: Drugs & Pharmacology Authors: Ibukun O Oresanya Ilkay Erdogan Orhan Source Type: research

An Updated Insight into Phytomolecules and Novel Approaches used in the Management of Breast Cancer
Curr Drug Targets. 2024 Jan 12. doi: 10.2174/0113894501277556231221072938. Online ahead of print.ABSTRACTBreast cancer is a widespread condition that kills more women from cancer-related causes than any other type of cancer globally. Women who have estrogen-dependent, initial metastatic breast cancer frequently receive treatment with surgery, radiation therapy, and chemotherapy. They may also get more specialized treatments like tamoxifen or aromatase inhibitors (anastrozole or letrozole). The World Health Organisation reported in 2012 that by 2030, breast cancer will be more common worldwide. There are several phytochemic...
Source: Current Drug Targets - January 17, 2024 Category: Drugs & Pharmacology Authors: Zulfa Nooreen Sudeep Tandon Ankita Wal Awani Kumar Rai Source Type: research

Exploring the Efficient Natural Products for the Therapy of Parkinson's Disease via Drosophila Melanogaster (Fruit Fly) Models
Curr Drug Targets. 2024 Jan 10. doi: 10.2174/0113894501281402231218071641. Online ahead of print.ABSTRACTParkinson's disease (PD) is a severe neurodegenerative disorder, partly attributed to mutations, environmental toxins, oxidative stress, abnormal protein aggregation, and mitochondrial dysfunction. However, the precise pathogenesis of PD and its treatment strategy still require investigation. Fortunately, natural products have demonstrated potential as therapeutic agents for alleviating PD symptoms due to their neuroprotective properties. To identify promising lead compounds from herbal medicines' natural products for P...
Source: Current Drug Targets - January 12, 2024 Category: Drugs & Pharmacology Authors: Wen Zhang Yingjie Ju Yunuo Ren Yaodong Miao Yiwen Wang Source Type: research

Molecular Targets and Mechanisms of Hedyotis diffusa Willd. for Esophageal Adenocarcinoma Treatment Based on Network Pharmacology and Weighted Gene Co-expression Network Analysis
CONCLUSION: Our findings shed light on the molecular underpinnings of HDW in the treatment of EAC and hold great promise for the identification of potential HDW compounds and biomarkers for EAC therapy.PMID:38213161 | DOI:10.2174/0113894501265851240102101122 (Source: Current Drug Targets)
Source: Current Drug Targets - January 12, 2024 Category: Drugs & Pharmacology Authors: Yu Zhuang Yun-Gang Sun Chen-Guang Wang Qiang Zhang Chao Che Feng Shao Source Type: research

Cytokines and Regulating Epithelial Cell Division
Curr Drug Targets. 2024 Jan 11. doi: 10.2174/0113894501279979240101051345. Online ahead of print.ABSTRACTPhysiologically, cytokines play an extremely important role in maintaining cellular and subcellular homeostasis, as they interact almost with every cell in the organism. Therefore, cytokines play a significantly critical role in the field of pathogenic pharmacological therapy of different types of pathologies. Cytokine is a large family containing many subfamilies and can be evaluated into groups according to their action on epithelial cell proliferation; stimulatory include transforming growth factor-α (TGF-α), Inter...
Source: Current Drug Targets - January 12, 2024 Category: Drugs & Pharmacology Authors: Basheer Abdullah Marzoog Source Type: research

Targeting Protein Phosphatases for the Treatment of Chronic Liver Disease
Curr Drug Targets. 2024 Jan 11. doi: 10.2174/0113894501278886231221092522. Online ahead of print.ABSTRACTThere exists a huge number of patients suffering from chronic liver disease worldwide. As a disease with high incidence and mortality worldwide, strengthening the research on the pathogenesis of chronic liver disease and the development of novel drugs is an important issue related to the health of all human beings. Phosphorylation modification of proteins plays a crucial role in cellular signal transduction, and phosphatases are involved in the development of liver diseases. Therefore, this article summarized the import...
Source: Current Drug Targets - January 12, 2024 Category: Drugs & Pharmacology Authors: Yi-Ming Li Hong-Wei He Na Zhang Source Type: research

A Review on the Recent Advancements and Artificial Intelligence in Tablet Technology
CONCLUSION: The integration of nanotechnology, AI, ML, and materials science with traditional pharmaceutical sciences presents a remarkable opportunity for enhancing tablet formulation processes. This review collectively underscores the transformative role that AI and ML can play in advancing pharmaceutical research and development, ultimately leading to more efficient, reliable and patient-centric tablet formulations.PMID:38213164 | DOI:10.2174/0113894501281290231221053939 (Source: Current Drug Targets)
Source: Current Drug Targets - January 12, 2024 Category: Drugs & Pharmacology Authors: Amit Sahu Sunny Rathee Shivani Saraf Sanjay K Jain Source Type: research

Efficacy and Possible Mechanisms of Astragali Radix and its Ingredients in Animal Models of Osteoporosis: A Preclinical Review and Metaanalysis
CONCLUSION: The findings suggest the possibility of developing IAR as a drug for the treatment of OP. IAR with longer treatment time may achieve better effects regardless of animal strain and age.PMID:38213165 | DOI:10.2174/0113894501275292231220062838 (Source: Current Drug Targets)
Source: Current Drug Targets - January 12, 2024 Category: Drugs & Pharmacology Authors: Ning Cao Zhangxuan Shou Yi Xiao Puqing Liu Source Type: research