Deciphering the Role of Pyroptosis Impact on Cardiovascular Diseases
Curr Drug Targets. 2023;24(15):1166-1183. doi: 10.2174/0113894501267496231102114410.ABSTRACTPyroptosis has become a noteworthy area of focus in recent years due to its association with inflammatory diseases. Pyroptosis is a type of programmed cell death accompanied by an inflammatory response, and the discovery of the gasdermin family has expanded the study of pyroptosis. The primary characteristics of pyroptosis include cell expansion, membrane penetration, and the ejection of cell contents. In healthy physiology, pyroptosis is an essential part of the host's defence against pathogen infection. Excessive Pyroptosis, howev...
Source: Current Drug Targets - January 2, 2024 Category: Drugs & Pharmacology Authors: Poonam Patil Gaurav Doshi Source Type: research

Biomarkers and Treatment Strategies for Breast Cancer Recurrence
This article aimed to summarise the primary causes of breast cancer recurrence and highlight the key issues that need to be addressed in order to effectively decrease the mortality rate among breast cancer patients. This article discusses various therapeutic approaches currently employed and emerging treatment strategies that hold the potential for the complete cure of cancer.PMID:38164731 | DOI:10.2174/0113894501258059231103072025 (Source: Current Drug Targets)
Source: Current Drug Targets - January 2, 2024 Category: Drugs & Pharmacology Authors: Shivam Rajput Pramod Kumar Sharma Rishabha Malviya Source Type: research

Deciphering the Role of Pyroptosis Impact on Cardiovascular Diseases
Curr Drug Targets. 2023;24(15):1166-1183. doi: 10.2174/0113894501267496231102114410.ABSTRACTPyroptosis has become a noteworthy area of focus in recent years due to its association with inflammatory diseases. Pyroptosis is a type of programmed cell death accompanied by an inflammatory response, and the discovery of the gasdermin family has expanded the study of pyroptosis. The primary characteristics of pyroptosis include cell expansion, membrane penetration, and the ejection of cell contents. In healthy physiology, pyroptosis is an essential part of the host's defence against pathogen infection. Excessive Pyroptosis, howev...
Source: Current Drug Targets - January 2, 2024 Category: Drugs & Pharmacology Authors: Poonam Patil Gaurav Doshi Source Type: research

Biomarkers and Treatment Strategies for Breast Cancer Recurrence
This article aimed to summarise the primary causes of breast cancer recurrence and highlight the key issues that need to be addressed in order to effectively decrease the mortality rate among breast cancer patients. This article discusses various therapeutic approaches currently employed and emerging treatment strategies that hold the potential for the complete cure of cancer.PMID:38164731 | DOI:10.2174/0113894501258059231103072025 (Source: Current Drug Targets)
Source: Current Drug Targets - January 2, 2024 Category: Drugs & Pharmacology Authors: Shivam Rajput Pramod Kumar Sharma Rishabha Malviya Source Type: research

Rho Kinase (ROCK) Inhibitors for the Treatment of Glaucoma
Curr Drug Targets. 2023 Dec 28. doi: 10.2174/0113894501286195231220094646. Online ahead of print.ABSTRACTGlaucoma is the most common cause of irreversible blindness worldwide. It is characterized by progressive optic nerve degeneration and loss of visual field. Pathological increased intraocular pressure is its main modifiable risk factor. Rho kinase inhibitors are developed as a new class of glaucoma medication that increases outflow facility from the conventional aqueous humor outflow pathway. Additionally, they also have neuropective and anti-scarring effects that can might increase the success rate of glaucoma filtrati...
Source: Current Drug Targets - December 29, 2023 Category: Drugs & Pharmacology Authors: Junhui Wu Jing Wei Haoliang Chen Yalong Dang Fang Lei Source Type: research

Rho Kinase (ROCK) Inhibitors for the Treatment of Glaucoma
Curr Drug Targets. 2023 Dec 28. doi: 10.2174/0113894501286195231220094646. Online ahead of print.ABSTRACTGlaucoma is the most common cause of irreversible blindness worldwide. It is characterized by progressive optic nerve degeneration and loss of visual field. Pathological increased intraocular pressure is its main modifiable risk factor. Rho kinase inhibitors are developed as a new class of glaucoma medication that increases outflow facility from the conventional aqueous humor outflow pathway. Additionally, they also have neuropective and anti-scarring effects that can might increase the success rate of glaucoma filtrati...
Source: Current Drug Targets - December 29, 2023 Category: Drugs & Pharmacology Authors: Junhui Wu Jing Wei Haoliang Chen Yalong Dang Fang Lei Source Type: research

Rho Kinase (ROCK) Inhibitors for the Treatment of Glaucoma
Curr Drug Targets. 2023 Dec 28. doi: 10.2174/0113894501286195231220094646. Online ahead of print.ABSTRACTGlaucoma is the most common cause of irreversible blindness worldwide. It is characterized by progressive optic nerve degeneration and loss of visual field. Pathological increased intraocular pressure is its main modifiable risk factor. Rho kinase inhibitors are developed as a new class of glaucoma medication that increases outflow facility from the conventional aqueous humor outflow pathway. Additionally, they also have neuropective and anti-scarring effects that can might increase the success rate of glaucoma filtrati...
Source: Current Drug Targets - December 29, 2023 Category: Drugs & Pharmacology Authors: Junhui Wu Jing Wei Haoliang Chen Yalong Dang Fang Lei Source Type: research

Rho Kinase (ROCK) Inhibitors for the Treatment of Glaucoma
Curr Drug Targets. 2023 Dec 28. doi: 10.2174/0113894501286195231220094646. Online ahead of print.ABSTRACTGlaucoma is the most common cause of irreversible blindness worldwide. It is characterized by progressive optic nerve degeneration and loss of visual field. Pathological increased intraocular pressure is its main modifiable risk factor. Rho kinase inhibitors are developed as a new class of glaucoma medication that increases outflow facility from the conventional aqueous humor outflow pathway. Additionally, they also have neuropective and anti-scarring effects that can might increase the success rate of glaucoma filtrati...
Source: Current Drug Targets - December 29, 2023 Category: Drugs & Pharmacology Authors: Junhui Wu Jing Wei Haoliang Chen Yalong Dang Fang Lei Source Type: research

ClpP Peptidase as a Plausible Target for the Discovery of Novel Antibiotics
Curr Drug Targets. 2023 Dec 27. doi: 10.2174/0113894501274958231220053714. Online ahead of print.ABSTRACTAntimicrobial resistance (AMR) to currently available antibiotics/drugs is a global threat. It is desirable to develop new drugs that work through a novel target(s) to avoid drug resistance. This review discusses the potential of the caseinolytic protease P (ClpP) peptidase complex as a novel target for finding novel antibiotics, emphasising the ClpP's structure and function. ClpP contributes to the survival of bacteria via its ability to destroy misfolded or aggregated proteins. In consequence, its inhibition may lead ...
Source: Current Drug Targets - December 28, 2023 Category: Drugs & Pharmacology Authors: Smriti Bhardwaj Kuldeep K Roy Source Type: research

Breaking Barriers: Current Advances and Future Directions in Mpox Therapy
CONCLUSION: In this summary, we provide an overview of potential drugs that could be used to treat Mpox and discuss the underlying biological processes of their actions.PMID:38151842 | DOI:10.2174/0113894501281263231218070841 (Source: Current Drug Targets)
Source: Current Drug Targets - December 28, 2023 Category: Drugs & Pharmacology Authors: Bhumi M Shah Palmi Modi Source Type: research

ClpP Peptidase as a Plausible Target for the Discovery of Novel Antibiotics
Curr Drug Targets. 2023 Dec 27. doi: 10.2174/0113894501274958231220053714. Online ahead of print.ABSTRACTAntimicrobial resistance (AMR) to currently available antibiotics/drugs is a global threat. It is desirable to develop new drugs that work through a novel target(s) to avoid drug resistance. This review discusses the potential of the caseinolytic protease P (ClpP) peptidase complex as a novel target for finding novel antibiotics, emphasising the ClpP's structure and function. ClpP contributes to the survival of bacteria via its ability to destroy misfolded or aggregated proteins. In consequence, its inhibition may lead ...
Source: Current Drug Targets - December 28, 2023 Category: Drugs & Pharmacology Authors: Smriti Bhardwaj Kuldeep K Roy Source Type: research

Breaking Barriers: Current Advances and Future Directions in Mpox Therapy
CONCLUSION: In this summary, we provide an overview of potential drugs that could be used to treat Mpox and discuss the underlying biological processes of their actions.PMID:38151842 | DOI:10.2174/0113894501281263231218070841 (Source: Current Drug Targets)
Source: Current Drug Targets - December 28, 2023 Category: Drugs & Pharmacology Authors: Bhumi M Shah Palmi Modi Source Type: research

Does the Grape Products Intake has an Effect on Body Weight in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials
CONCLUSION: Our study suggests that grape products intake may help to decrease body weight in obese participants. Future large RCTs with longer duration and obese populations are needed to expand our findings.PMID:38141198 | DOI:10.2174/0113894501272740231219072525 (Source: Current Drug Targets)
Source: Current Drug Targets - December 23, 2023 Category: Drugs & Pharmacology Authors: Mohammad Ali Goudarzi Zahra Sohrabi Mohammad Hashem Hashempur Saeed Nosratabadi Zahra Namkhah Cain C T Clark Neda Haghighat Source Type: research

Does the Grape Products Intake has an Effect on Body Weight in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials
CONCLUSION: Our study suggests that grape products intake may help to decrease body weight in obese participants. Future large RCTs with longer duration and obese populations are needed to expand our findings.PMID:38141198 | DOI:10.2174/0113894501272740231219072525 (Source: Current Drug Targets)
Source: Current Drug Targets - December 23, 2023 Category: Drugs & Pharmacology Authors: Mohammad Ali Goudarzi Zahra Sohrabi Mohammad Hashem Hashempur Saeed Nosratabadi Zahra Namkhah Cain C T Clark Neda Haghighat Source Type: research

Does the Grape Products Intake has an Effect on Body Weight in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials
CONCLUSION: Our study suggests that grape products intake may help to decrease body weight in obese participants. Future large RCTs with longer duration and obese populations are needed to expand our findings.PMID:38141198 | DOI:10.2174/0113894501272740231219072525 (Source: Current Drug Targets)
Source: Current Drug Targets - December 23, 2023 Category: Drugs & Pharmacology Authors: Mohammad Ali Goudarzi Zahra Sohrabi Mohammad Hashem Hashempur Saeed Nosratabadi Zahra Namkhah Cain C T Clark Neda Haghighat Source Type: research