The (pro)renin Receptor - A Regulatory Nodal Point in Disease Networks
Curr Drug Targets. 2023 Oct 25. doi: 10.2174/0113894501250617231016052930. Online ahead of print.ABSTRACTExperimental inhibition of the (pro)renin receptor [(P)RR] is a promising therapeutic strategy in different disease models ranging from cardiorenal to oncological entities. Here, we briefly review the direct protein-protein interaction partners of the (P)RR and the plethora of distinct diseases in which the (P)RR is involved. The first structural work on the (P)RR using AlphaFold, which was recently published by Ebihara et al., is the center of this mini-review since it can mechanistically link the protein-protein inter...
Source: Current Drug Targets - October 27, 2023 Category: Drugs & Pharmacology Authors: Heiko Funke-Kaiser Thomas Unger Source Type: research

The (pro)renin Receptor - A Regulatory Nodal Point in Disease Networks
Curr Drug Targets. 2023 Oct 25. doi: 10.2174/0113894501250617231016052930. Online ahead of print.ABSTRACTExperimental inhibition of the (pro)renin receptor [(P)RR] is a promising therapeutic strategy in different disease models ranging from cardiorenal to oncological entities. Here, we briefly review the direct protein-protein interaction partners of the (P)RR and the plethora of distinct diseases in which the (P)RR is involved. The first structural work on the (P)RR using AlphaFold, which was recently published by Ebihara et al., is the center of this mini-review since it can mechanistically link the protein-protein inter...
Source: Current Drug Targets - October 27, 2023 Category: Drugs & Pharmacology Authors: Heiko Funke-Kaiser Thomas Unger Source Type: research

The Surging Mechanistic Role of Angiotensin Converting Enzyme 2 in Human Pathologies: A Potential Approach for Herbal Therapeutics
Curr Drug Targets. 2023 Oct 11. doi: 10.2174/0113894501247616231009065415. Online ahead of print.ABSTRACTAdvancements in biological sciences revealed the significant role of angiotensin-converting enzyme 2 (ACE2), a key cell surface receptor in various human pathologies. ACE2 is a metalloproteinase that not only functions in the regulation of Angiotensin II but also possesses some non-catalytic roles in the human body. There is considerable uncertainty regarding its protein expression, despite its presence in virtually all organs. The level of ACE2 expression and its subcellular localisation in humans may be a key determin...
Source: Current Drug Targets - October 20, 2023 Category: Drugs & Pharmacology Authors: Priyadarshini Gupta Vibha Rani Source Type: research

Viaminate Inhibits < em > Propionibacterium < /em > Acnes-induced Abnormal Proliferation and Keratinization of HaCat Cells by Regulating the S100A8/S100A9- MAPK Cascade
CONCLUSION: In summary, viaminate can improve acne by modulating S100A8 and S100A9 to inhibit MAPK pathway activation and inhibit keratinocyte proliferation and keratinization levels.PMID:37861037 | DOI:10.2174/0113894501243867230928115205 (Source: Current Drug Targets)
Source: Current Drug Targets - October 20, 2023 Category: Drugs & Pharmacology Authors: Junjie Cao Meifeng Xu Longfei Zhu Shengxiang Xiao Source Type: research

The Surging Mechanistic Role of Angiotensin Converting Enzyme 2 in Human Pathologies: A Potential Approach for Herbal Therapeutics
Curr Drug Targets. 2023 Oct 11. doi: 10.2174/0113894501247616231009065415. Online ahead of print.ABSTRACTAdvancements in biological sciences revealed the significant role of angiotensin-converting enzyme 2 (ACE2), a key cell surface receptor in various human pathologies. ACE2 is a metalloproteinase that not only functions in the regulation of Angiotensin II but also possesses some non-catalytic roles in the human body. There is considerable uncertainty regarding its protein expression, despite its presence in virtually all organs. The level of ACE2 expression and its subcellular localisation in humans may be a key determin...
Source: Current Drug Targets - October 20, 2023 Category: Drugs & Pharmacology Authors: Priyadarshini Gupta Vibha Rani Source Type: research

Viaminate Inhibits < em > Propionibacterium < /em > Acnes-induced Abnormal Proliferation and Keratinization of HaCat Cells by Regulating the S100A8/S100A9- MAPK Cascade
CONCLUSION: In summary, viaminate can improve acne by modulating S100A8 and S100A9 to inhibit MAPK pathway activation and inhibit keratinocyte proliferation and keratinization levels.PMID:37861037 | DOI:10.2174/0113894501243867230928115205 (Source: Current Drug Targets)
Source: Current Drug Targets - October 20, 2023 Category: Drugs & Pharmacology Authors: Junjie Cao Meifeng Xu Longfei Zhu Shengxiang Xiao Source Type: research

The Surging Mechanistic Role of Angiotensin Converting Enzyme 2 in Human Pathologies: A Potential Approach for Herbal Therapeutics
Curr Drug Targets. 2023 Oct 11. doi: 10.2174/0113894501247616231009065415. Online ahead of print.ABSTRACTAdvancements in biological sciences revealed the significant role of angiotensin-converting enzyme 2 (ACE2), a key cell surface receptor in various human pathologies. ACE2 is a metalloproteinase that not only functions in the regulation of Angiotensin II but also possesses some non-catalytic roles in the human body. There is considerable uncertainty regarding its protein expression, despite its presence in virtually all organs. The level of ACE2 expression and its subcellular localisation in humans may be a key determin...
Source: Current Drug Targets - October 20, 2023 Category: Drugs & Pharmacology Authors: Priyadarshini Gupta Vibha Rani Source Type: research

Viaminate Inhibits < em > Propionibacterium < /em > Acnes-induced Abnormal Proliferation and Keratinization of HaCat Cells by Regulating the S100A8/S100A9- MAPK Cascade
CONCLUSION: In summary, viaminate can improve acne by modulating S100A8 and S100A9 to inhibit MAPK pathway activation and inhibit keratinocyte proliferation and keratinization levels.PMID:37861037 | DOI:10.2174/0113894501243867230928115205 (Source: Current Drug Targets)
Source: Current Drug Targets - October 20, 2023 Category: Drugs & Pharmacology Authors: Junjie Cao Meifeng Xu Longfei Zhu Shengxiang Xiao Source Type: research

The Surging Mechanistic Role of Angiotensin Converting Enzyme 2 in Human Pathologies: A Potential Approach for Herbal Therapeutics
Curr Drug Targets. 2023 Oct 11. doi: 10.2174/0113894501247616231009065415. Online ahead of print.ABSTRACTAdvancements in biological sciences revealed the significant role of angiotensin-converting enzyme 2 (ACE2), a key cell surface receptor in various human pathologies. ACE2 is a metalloproteinase that not only functions in the regulation of Angiotensin II but also possesses some non-catalytic roles in the human body. There is considerable uncertainty regarding its protein expression, despite its presence in virtually all organs. The level of ACE2 expression and its subcellular localisation in humans may be a key determin...
Source: Current Drug Targets - October 20, 2023 Category: Drugs & Pharmacology Authors: Priyadarshini Gupta Vibha Rani Source Type: research

Viaminate Inhibits < em > Propionibacterium < /em > Acnes-induced Abnormal Proliferation and Keratinization of HaCat Cells by Regulating the S100A8/S100A9- MAPK Cascade
CONCLUSION: In summary, viaminate can improve acne by modulating S100A8 and S100A9 to inhibit MAPK pathway activation and inhibit keratinocyte proliferation and keratinization levels.PMID:37861037 | DOI:10.2174/0113894501243867230928115205 (Source: Current Drug Targets)
Source: Current Drug Targets - October 20, 2023 Category: Drugs & Pharmacology Authors: Junjie Cao Meifeng Xu Longfei Zhu Shengxiang Xiao Source Type: research

The Surging Mechanistic Role of Angiotensin Converting Enzyme 2 in Human Pathologies: A Potential Approach for Herbal Therapeutics
Curr Drug Targets. 2023 Oct 11. doi: 10.2174/0113894501247616231009065415. Online ahead of print.ABSTRACTAdvancements in biological sciences revealed the significant role of angiotensin-converting enzyme 2 (ACE2), a key cell surface receptor in various human pathologies. ACE2 is a metalloproteinase that not only functions in the regulation of Angiotensin II but also possesses some non-catalytic roles in the human body. There is considerable uncertainty regarding its protein expression, despite its presence in virtually all organs. The level of ACE2 expression and its subcellular localisation in humans may be a key determin...
Source: Current Drug Targets - October 20, 2023 Category: Drugs & Pharmacology Authors: Priyadarshini Gupta Vibha Rani Source Type: research

Viaminate Inhibits < em > Propionibacterium < /em > Acnes-induced Abnormal Proliferation and Keratinization of HaCat Cells by Regulating the S100A8/S100A9- MAPK Cascade
CONCLUSION: In summary, viaminate can improve acne by modulating S100A8 and S100A9 to inhibit MAPK pathway activation and inhibit keratinocyte proliferation and keratinization levels.PMID:37861037 | DOI:10.2174/0113894501243867230928115205 (Source: Current Drug Targets)
Source: Current Drug Targets - October 20, 2023 Category: Drugs & Pharmacology Authors: Junjie Cao Meifeng Xu Longfei Zhu Shengxiang Xiao Source Type: research

BRD4 Protein as a Target for Lung Cancer and Hematological Cancer Therapy: A Review
Curr Drug Targets. 2023 Oct 16. doi: 10.2174/0113894501269090231012090351. Online ahead of print.ABSTRACTThe BET protein family plays a crucial role in regulating the epigenetic landscape of the genome. Their role in regulating tumor-related gene expression and its impact on the survival of tumor cells is widely acknowledged. Among the BET family constituents, BRD4 is a significant protein. It is a bromodomain-containing protein located at the outer terminal that recognizes histones that have undergone acetylation. It is present in the promoter or enhancer region of the target gene and is responsible for initiating and sus...
Source: Current Drug Targets - October 17, 2023 Category: Drugs & Pharmacology Authors: Mengmeng Zhang Yingbo Li Zilong Zhang Xin Zhang Wei Wang Xiaomei Song Dongdong Zhang Source Type: research

BRD4 Protein as a Target for Lung Cancer and Hematological Cancer Therapy: A Review
Curr Drug Targets. 2023 Oct 16. doi: 10.2174/0113894501269090231012090351. Online ahead of print.ABSTRACTThe BET protein family plays a crucial role in regulating the epigenetic landscape of the genome. Their role in regulating tumor-related gene expression and its impact on the survival of tumor cells is widely acknowledged. Among the BET family constituents, BRD4 is a significant protein. It is a bromodomain-containing protein located at the outer terminal that recognizes histones that have undergone acetylation. It is present in the promoter or enhancer region of the target gene and is responsible for initiating and sus...
Source: Current Drug Targets - October 17, 2023 Category: Drugs & Pharmacology Authors: Mengmeng Zhang Yingbo Li Zilong Zhang Xin Zhang Wei Wang Xiaomei Song Dongdong Zhang Source Type: research

BRD4 Protein as a Target for Lung Cancer and Hematological Cancer Therapy: A Review
Curr Drug Targets. 2023 Oct 16. doi: 10.2174/0113894501269090231012090351. Online ahead of print.ABSTRACTThe BET protein family plays a crucial role in regulating the epigenetic landscape of the genome. Their role in regulating tumor-related gene expression and its impact on the survival of tumor cells is widely acknowledged. Among the BET family constituents, BRD4 is a significant protein. It is a bromodomain-containing protein located at the outer terminal that recognizes histones that have undergone acetylation. It is present in the promoter or enhancer region of the target gene and is responsible for initiating and sus...
Source: Current Drug Targets - October 17, 2023 Category: Drugs & Pharmacology Authors: Mengmeng Zhang Yingbo Li Zilong Zhang Xin Zhang Wei Wang Xiaomei Song Dongdong Zhang Source Type: research