A comprehensive insight on pharmaceutical co-crystals for improvement of aqueous solubility
Curr Drug Targets. 2022 Nov 14. doi: 10.2174/1389450124666221114095400. Online ahead of print.ABSTRACTVarious drugs are not able to reach the market due to their poor bioavailability and poor solubility in aqueous media. Hence, several approaches are used to enhance the solubility of poorly water-soluble drugs. Co-crystallization is one of the approaches used to enhance the solubility of poorly water-soluble drugs. Co-crystals are solid crystalline substances consisting of two or more ingredients in a stoichiometric ratio in which one of the ingredients is an active pharmaceutical ingredient (API) and the other is a co-for...
Source: Current Drug Targets - November 16, 2022 Category: Drugs & Pharmacology Authors: Jyoti Malik Anurag Khatkar Arun Nanda Source Type: research
A comprehensive insight on pharmaceutical co-crystals for improvement of aqueous solubility
Curr Drug Targets. 2022 Nov 14. doi: 10.2174/1389450124666221114095400. Online ahead of print.ABSTRACTVarious drugs are not able to reach the market due to their poor bioavailability and poor solubility in aqueous media. Hence, several approaches are used to enhance the solubility of poorly water-soluble drugs. Co-crystallization is one of the approaches used to enhance the solubility of poorly water-soluble drugs. Co-crystals are solid crystalline substances consisting of two or more ingredients in a stoichiometric ratio in which one of the ingredients is an active pharmaceutical ingredient (API) and the other is a co-for...
Source: Current Drug Targets - November 16, 2022 Category: Drugs & Pharmacology Authors: Jyoti Malik Anurag Khatkar Arun Nanda Source Type: research
Melanocortin receptors: emerging targets for the treatment of pigmentation, inflammation, stress, weight disorders and sexual dysfunction
Curr Drug Targets. 2022 Nov 8. doi: 10.2174/1389450124666221108143006. Online ahead of print.ABSTRACTMelanocortins are tiny protein molecules formed by the post-translational cleavage of proopiomelanocortin. These are bioactive peptides that are responsible for human and lower animal pigmentation patterns, energy homeostasis, and sexual function modulation. These peptides regulate numerous physiological functions by being generated in the central nervous system and peripheral tissues. Melanocortins elicit their varied biological effects by binding to a separate family of G protein, two primary proteolytic enzymes, proconve...
Source: Current Drug Targets - November 11, 2022 Category: Drugs & Pharmacology Authors: Miteshkumar Maurya Renuka Munshi Sachin Zambre Source Type: research
Melanocortin receptors: emerging targets for the treatment of pigmentation, inflammation, stress, weight disorders and sexual dysfunction
Curr Drug Targets. 2022 Nov 8. doi: 10.2174/1389450124666221108143006. Online ahead of print.ABSTRACTMelanocortins are tiny protein molecules formed by the post-translational cleavage of proopiomelanocortin. These are bioactive peptides that are responsible for human and lower animal pigmentation patterns, energy homeostasis, and sexual function modulation. These peptides regulate numerous physiological functions by being generated in the central nervous system and peripheral tissues. Melanocortins elicit their varied biological effects by binding to a separate family of G protein, two primary proteolytic enzymes, proconve...
Source: Current Drug Targets - November 11, 2022 Category: Drugs & Pharmacology Authors: Miteshkumar Maurya Renuka Munshi Sachin Zambre Source Type: research
Melanocortin receptors: emerging targets for the treatment of pigmentation, inflammation, stress, weight disorders and sexual dysfunction
Curr Drug Targets. 2022 Nov 8. doi: 10.2174/1389450124666221108143006. Online ahead of print.ABSTRACTMelanocortins are tiny protein molecules formed by the post-translational cleavage of proopiomelanocortin. These are bioactive peptides that are responsible for human and lower animal pigmentation patterns, energy homeostasis, and sexual function modulation. These peptides regulate numerous physiological functions by being generated in the central nervous system and peripheral tissues. Melanocortins elicit their varied biological effects by binding to a separate family of G protein, two primary proteolytic enzymes, proconve...
Source: Current Drug Targets - November 11, 2022 Category: Drugs & Pharmacology Authors: Miteshkumar Maurya Renuka Munshi Sachin Zambre Source Type: research
Melanocortin receptors: emerging targets for the treatment of pigmentation, inflammation, stress, weight disorders and sexual dysfunction
Curr Drug Targets. 2022 Nov 8. doi: 10.2174/1389450124666221108143006. Online ahead of print.ABSTRACTMelanocortins are tiny protein molecules formed by the post-translational cleavage of proopiomelanocortin. These are bioactive peptides that are responsible for human and lower animal pigmentation patterns, energy homeostasis, and sexual function modulation. These peptides regulate numerous physiological functions by being generated in the central nervous system and peripheral tissues. Melanocortins elicit their varied biological effects by binding to a separate family of G protein, two primary proteolytic enzymes, proconve...
Source: Current Drug Targets - November 11, 2022 Category: Drugs & Pharmacology Authors: Miteshkumar Maurya Renuka Munshi Sachin Zambre Source Type: research
Metformin: a promising antidiabetic medication for cancer treatment
Curr Drug Targets. 2022 Nov 4. doi: 10.2174/1389450124666221104094918. Online ahead of print.ABSTRACTMetformin is a widely used drug in patients with type 2 diabetes mellitus. Metformin inhibits hepatic gluconeogenesis and increases glucose utilization in peripheral tissues. In recent years, several studies have shown that metformin is a potential therapeutic agent against cancer, alone or combined with other anticancer treatments. Metformin mainly activates the AMPK complex and regulates intracellular energy status, inhibiting the mitochondrial respiratory chain complex I and reducing the production of reactive oxygen spe...
Source: Current Drug Targets - November 6, 2022 Category: Drugs & Pharmacology Authors: Wei Mu Yunyun Jiang Guoqiang Liang Yue Feng Falin Qu Source Type: research
Metformin: a promising antidiabetic medication for cancer treatment
Curr Drug Targets. 2022 Nov 4. doi: 10.2174/1389450124666221104094918. Online ahead of print.ABSTRACTMetformin is a widely used drug in patients with type 2 diabetes mellitus. Metformin inhibits hepatic gluconeogenesis and increases glucose utilization in peripheral tissues. In recent years, several studies have shown that metformin is a potential therapeutic agent against cancer, alone or combined with other anticancer treatments. Metformin mainly activates the AMPK complex and regulates intracellular energy status, inhibiting the mitochondrial respiratory chain complex I and reducing the production of reactive oxygen spe...
Source: Current Drug Targets - November 6, 2022 Category: Drugs & Pharmacology Authors: Wei Mu Yunyun Jiang Guoqiang Liang Yue Feng Falin Qu Source Type: research
Metformin: a promising antidiabetic medication for cancer treatment
Curr Drug Targets. 2022 Nov 4. doi: 10.2174/1389450124666221104094918. Online ahead of print.ABSTRACTMetformin is a widely used drug in patients with type 2 diabetes mellitus. Metformin inhibits hepatic gluconeogenesis and increases glucose utilization in peripheral tissues. In recent years, several studies have shown that metformin is a potential therapeutic agent against cancer, alone or combined with other anticancer treatments. Metformin mainly activates the AMPK complex and regulates intracellular energy status, inhibiting the mitochondrial respiratory chain complex I and reducing the production of reactive oxygen spe...
Source: Current Drug Targets - November 6, 2022 Category: Drugs & Pharmacology Authors: Wei Mu Yunyun Jiang Guoqiang Liang Yue Feng Falin Qu Source Type: research
Metformin: a promising antidiabetic medication for cancer treatment
Curr Drug Targets. 2022 Nov 4. doi: 10.2174/1389450124666221104094918. Online ahead of print.ABSTRACTMetformin is a widely used drug in patients with type 2 diabetes mellitus. Metformin inhibits hepatic gluconeogenesis and increases glucose utilization in peripheral tissues. In recent years, several studies have shown that metformin is a potential therapeutic agent against cancer, alone or combined with other anticancer treatments. Metformin mainly activates the AMPK complex and regulates intracellular energy status, inhibiting the mitochondrial respiratory chain complex I and reducing the production of reactive oxygen spe...
Source: Current Drug Targets - November 6, 2022 Category: Drugs & Pharmacology Authors: Wei Mu Yunyun Jiang Guoqiang Liang Yue Feng Falin Qu Source Type: research
The Mechanistic Role of Different Mediators in the Pathophysiology of Nephropathy: A Review
Curr Drug Targets. 2022 Oct 26. doi: 10.2174/1389450124666221026152647. Online ahead of print.ABSTRACTNephropathy has become the most common reason for end-stage renal disease worldwide. The progression of end-stage renal disease occurs caused by decreased glomerular filtration rate, damage to capillaries in renal glomeruli or a higher risk of cardiovascular morbidity and mortality in diabetic patients. The involvement of mechanism in the development of nephropathy via generation of AGEs, the elevation of growth factors, altered hemodynamic and metabolic factors, inflammatory mediators, oxidative stress and dyslipidaemia. ...
Source: Current Drug Targets - October 28, 2022 Category: Drugs & Pharmacology Authors: Jaspreet Singh Akash Jain Rashmi Bhamra Vaibhav Rathi Ashwani K Dhingra Source Type: research
The Mechanistic Role of Different Mediators in the Pathophysiology of Nephropathy: A Review
Curr Drug Targets. 2022 Oct 26. doi: 10.2174/1389450124666221026152647. Online ahead of print.ABSTRACTNephropathy has become the most common reason for end-stage renal disease worldwide. The progression of end-stage renal disease occurs caused by decreased glomerular filtration rate, damage to capillaries in renal glomeruli or a higher risk of cardiovascular morbidity and mortality in diabetic patients. The involvement of mechanism in the development of nephropathy via generation of AGEs, the elevation of growth factors, altered hemodynamic and metabolic factors, inflammatory mediators, oxidative stress and dyslipidaemia. ...
Source: Current Drug Targets - October 28, 2022 Category: Drugs & Pharmacology Authors: Jaspreet Singh Akash Jain Rashmi Bhamra Vaibhav Rathi Ashwani K Dhingra Source Type: research
The Mechanistic Role of Different Mediators in the Pathophysiology of Nephropathy: A Review
Curr Drug Targets. 2022 Oct 26. doi: 10.2174/1389450124666221026152647. Online ahead of print.ABSTRACTNephropathy has become the most common reason for end-stage renal disease worldwide. The progression of end-stage renal disease occurs caused by decreased glomerular filtration rate, damage to capillaries in renal glomeruli or a higher risk of cardiovascular morbidity and mortality in diabetic patients. The involvement of mechanism in the development of nephropathy via generation of AGEs, the elevation of growth factors, altered hemodynamic and metabolic factors, inflammatory mediators, oxidative stress and dyslipidaemia. ...
Source: Current Drug Targets - October 28, 2022 Category: Drugs & Pharmacology Authors: Jaspreet Singh Akash Jain Rashmi Bhamra Vaibhav Rathi Ashwani K Dhingra Source Type: research
The Mechanistic Role of Different Mediators in the Pathophysiology of Nephropathy: A Review
Curr Drug Targets. 2022 Oct 26. doi: 10.2174/1389450124666221026152647. Online ahead of print.ABSTRACTNephropathy has become the most common reason for end-stage renal disease worldwide. The progression of end-stage renal disease occurs caused by decreased glomerular filtration rate, damage to capillaries in renal glomeruli or a higher risk of cardiovascular morbidity and mortality in diabetic patients. The involvement of mechanism in the development of nephropathy via generation of AGEs, the elevation of growth factors, altered hemodynamic and metabolic factors, inflammatory mediators, oxidative stress and dyslipidaemia. ...
Source: Current Drug Targets - October 28, 2022 Category: Drugs & Pharmacology Authors: Jaspreet Singh Akash Jain Rashmi Bhamra Vaibhav Rathi Ashwani K Dhingra Source Type: research
The Mechanistic Role of Different Mediators in the Pathophysiology of Nephropathy: A Review
Curr Drug Targets. 2022 Oct 26. doi: 10.2174/1389450124666221026152647. Online ahead of print.ABSTRACTNephropathy has become the most common reason for end-stage renal disease worldwide. The progression of end-stage renal disease occurs caused by decreased glomerular filtration rate, damage to capillaries in renal glomeruli or a higher risk of cardiovascular morbidity and mortality in diabetic patients. The involvement of mechanism in the development of nephropathy via generation of AGEs, the elevation of growth factors, altered hemodynamic and metabolic factors, inflammatory mediators, oxidative stress and dyslipidaemia. ...
Source: Current Drug Targets - October 28, 2022 Category: Drugs & Pharmacology Authors: Jaspreet Singh Akash Jain Rashmi Bhamra Vaibhav Rathi Ashwani K Dhingra Source Type: research
