An Update on the Emerging Role of Wnt/ β-catenin, SYK, PI3K/AKT, and GM-CSF Signaling Pathways in Rheumatoid Arthritis
Curr Drug Targets. 2023 Dec 11. doi: 10.2174/0113894501276093231206064243. Online ahead of print.ABSTRACTRheumatoid arthritis is an untreatable autoimmune disorder. The disease is accompanied by joint impairment and anomalies, which negatively affect the patient's quality of life and contribute to a decline in manpower. To diagnose and treat rheumatoid arthritis, it is crucial to understand the abnormal signaling pathways that contribute to the disease. This understanding will help develop new rheumatoid arthritis-related intervention targets. Over the last few decades, researchers have given more attention to rheumatoid a...
Source: Current Drug Targets - December 12, 2023 Category: Drugs & Pharmacology Authors: Pradyuman Prajapati Gaurav Doshi Source Type: research

Recent Progress and Challenges in Clinical Translation of Nanomedicines in Diagnosis and Treatment of Lung Cancer
Curr Drug Targets. 2023 Dec 6. doi: 10.2174/0113894501273651231201061144. Online ahead of print.ABSTRACTLung cancer is one of the leading causes of death across the world. There are numerous challenges in the early diagnosis and effective treatment of lung cancer, including developing multidrug resistance. However, the diagnosis of lung cancer could be minimally invasive or non-invasive. Nowadays, nanomedicines offer solutions to several emerging challenges in drug delivery research areas. It has the potential to enhance the therapeutic efficacy of biologically and chemically active agents at the site of action. This appro...
Source: Current Drug Targets - December 7, 2023 Category: Drugs & Pharmacology Authors: Bhavna Yadav Mahima Chauhan Rahul Pratap Singh None Sonali Saurabh Shekhar Source Type: research

Recent Progress and Challenges in Clinical Translation of Nanomedicines in Diagnosis and Treatment of Lung Cancer
Curr Drug Targets. 2023 Dec 6. doi: 10.2174/0113894501273651231201061144. Online ahead of print.ABSTRACTLung cancer is one of the leading causes of death across the world. There are numerous challenges in the early diagnosis and effective treatment of lung cancer, including developing multidrug resistance. However, the diagnosis of lung cancer could be minimally invasive or non-invasive. Nowadays, nanomedicines offer solutions to several emerging challenges in drug delivery research areas. It has the potential to enhance the therapeutic efficacy of biologically and chemically active agents at the site of action. This appro...
Source: Current Drug Targets - December 7, 2023 Category: Drugs & Pharmacology Authors: Bhavna Yadav Mahima Chauhan Rahul Pratap Singh None Sonali Saurabh Shekhar Source Type: research

Recent Progress and Challenges in Clinical Translation of Nanomedicines in Diagnosis and Treatment of Lung Cancer
Curr Drug Targets. 2023 Dec 6. doi: 10.2174/0113894501273651231201061144. Online ahead of print.ABSTRACTLung cancer is one of the leading causes of death across the world. There are numerous challenges in the early diagnosis and effective treatment of lung cancer, including developing multidrug resistance. However, the diagnosis of lung cancer could be minimally invasive or non-invasive. Nowadays, nanomedicines offer solutions to several emerging challenges in drug delivery research areas. It has the potential to enhance the therapeutic efficacy of biologically and chemically active agents at the site of action. This appro...
Source: Current Drug Targets - December 7, 2023 Category: Drugs & Pharmacology Authors: Bhavna Yadav Mahima Chauhan Rahul Pratap Singh None Sonali Saurabh Shekhar Source Type: research

Recent Progress and Challenges in Clinical Translation of Nanomedicines in Diagnosis and Treatment of Lung Cancer
Curr Drug Targets. 2023 Dec 6. doi: 10.2174/0113894501273651231201061144. Online ahead of print.ABSTRACTLung cancer is one of the leading causes of death across the world. There are numerous challenges in the early diagnosis and effective treatment of lung cancer, including developing multidrug resistance. However, the diagnosis of lung cancer could be minimally invasive or non-invasive. Nowadays, nanomedicines offer solutions to several emerging challenges in drug delivery research areas. It has the potential to enhance the therapeutic efficacy of biologically and chemically active agents at the site of action. This appro...
Source: Current Drug Targets - December 7, 2023 Category: Drugs & Pharmacology Authors: Bhavna Yadav Mahima Chauhan Rahul Pratap Singh None Sonali Saurabh Shekhar Source Type: research

Recent Progress and Challenges in Clinical Translation of Nanomedicines in Diagnosis and Treatment of Lung Cancer
Curr Drug Targets. 2023 Dec 6. doi: 10.2174/0113894501273651231201061144. Online ahead of print.ABSTRACTLung cancer is one of the leading causes of death across the world. There are numerous challenges in the early diagnosis and effective treatment of lung cancer, including developing multidrug resistance. However, the diagnosis of lung cancer could be minimally invasive or non-invasive. Nowadays, nanomedicines offer solutions to several emerging challenges in drug delivery research areas. It has the potential to enhance the therapeutic efficacy of biologically and chemically active agents at the site of action. This appro...
Source: Current Drug Targets - December 7, 2023 Category: Drugs & Pharmacology Authors: Bhavna Yadav Mahima Chauhan Rahul Pratap Singh None Sonali Saurabh Shekhar Source Type: research

Therapeutic Potential of Targeting Transforming Growth Factor-beta (TGF- β) and Programmed Death-ligand 1 (PD-L1) in Pancreatic Cancer
Curr Drug Targets. 2023 Dec 5. doi: 10.2174/0113894501264450231129042256. Online ahead of print.ABSTRACTPancreatic cancer (PC) is one the most lethal malignancies worldwide affecting around half a million individuals each year. The treatment of PC is relatively difficult due to the difficulty in making an early diagnosis. Transforming growth factor-beta (TGF-β) is a multifunctional factor acting as both a tumor promoter in early cancer stages and a tumor suppressor in advanced disease. Programmed death-ligand 1 (PD-L1) is a ligand of programmed death-1 (PD-1), an immune checkpoint receptor, allowing tumor cells to avoid e...
Source: Current Drug Targets - December 6, 2023 Category: Drugs & Pharmacology Authors: Ghazaleh Pourali Nima Zafari Mahla Velayati Shima Mehrabadi Mina Maftooh Seyed Mahdi Hassanian Majid Ghayour-Mobarhan Gordon A Ferns Amir Avan Majid Khazaei Source Type: research

An Outbreak of Eye Flu Virus in India
Curr Drug Targets. 2023 Dec 5. doi: 10.2174/0113894501275247231129112022. Online ahead of print.NO ABSTRACTPMID:38053356 | DOI:10.2174/0113894501275247231129112022 (Source: Current Drug Targets)
Source: Current Drug Targets - December 6, 2023 Category: Drugs & Pharmacology Authors: Raj Kamal Debanjan Mukherjee Amandeep Singh Source Type: research

Antiviral Potential of Traditional Unani Medicine in Viral Diseases with Special Emphasis on Dengue: A Review
Curr Drug Targets. 2023 Nov 21. doi: 10.2174/0113894501257577231103044735. Online ahead of print.ABSTRACTDengue fever has become a major public health concern. It is usually related to intravascular leaking, bleeding disorders, and thrombocytopenia and is recognized as a potent threat to humans. The scarcity of anti-dengue medication or vaccine for such a serious disease leads to an upsurge in the usage of traditional medicines for its proper management. India has diverse biodiversity and a long history of using plant-based remedies. Several medicinal plant extracts have been studied for producing anti-dengue viral activit...
Source: Current Drug Targets - December 1, 2023 Category: Drugs & Pharmacology Authors: Muzayyana Khan Mohammad Altamish Monalisha Samal Varsha Srivastava Areeba Insaf Rabea Parveen Jamal Akhtar Anuja Krishnan Sayeed Ahmad Source Type: research

Flavonoids as G Protein-coupled Receptors Ligands: New Potential Therapeutic Natural Drugs
Curr Drug Targets. 2023 Nov 30. doi: 10.2174/0113894501268871231127105219. Online ahead of print.ABSTRACTG protein coupled receptors (GPCRs) are among the largest family of cell surface re-ceptors found in the human genome. They govern a wide range of physiological responses in both health and diseases, making them one of the potential targeted surface receptors for pharmaceuti-cals. Flavonoids can modulate GPCRs activity by acting as allosteric ligands. They can either en-hance or reduce the GPCR's effect. Emerging research shows that individual flavonoids or mix-tures of flavonoids from plant extract can have relevant ph...
Source: Current Drug Targets - December 1, 2023 Category: Drugs & Pharmacology Authors: Rachid Bencheikh Alae Chda Source Type: research

Novel Targets and Drug Delivery System in the Treatment of Postoperative Pain: Recent Studies and Clinical Advancement
Curr Drug Targets. 2023 Nov 30. doi: 10.2174/0113894501271207231127063431. Online ahead of print.ABSTRACTPain is generated by a small number of peripheral targets. These can be made more sensitive by inflammatory mediators. The number of opioids prescribed to the patients can be reduced dramatically with better pain management. Any therapy that safely and reliably provides extended analgesia and is flexible enough to facilitate a diverse array of release profiles would be useful for improving patient comfort, quality of care, and compliance after surgical procedures. Comparisons are made between new and traditional methods...
Source: Current Drug Targets - December 1, 2023 Category: Drugs & Pharmacology Authors: Trilochan Satapathy Gulab Singh Ravindra Kumar Pandey Shiv Shankar Shukla Shiv Kumar Bhardwaj Beena Gidwani Source Type: research

The Development of the Combination Drug Leukovir ® Tablets for the Treatment of Multiple Sclerosis: A Comprehensive Review
Curr Drug Targets. 2023 Nov 30. doi: 10.2174/0113894501272301231124074141. Online ahead of print.ABSTRACTThe review is devoted to the development and study of the drug Leukovir® (cladribine+ ribavirin) and its use in the treatment of relapsing-remitting and secondary progressive forms of multiple sclerosis, a chronic neurodegenerative disease aiming the risk reduction of relapse and progression of a disability. In clinical trials Leukovir® has proved to be efficient by up to 56 weeks for the treatment of relapsing-remitting and secondary progressive forms of multiple sclerosis. The drug is registered in the Republic of B...
Source: Current Drug Targets - December 1, 2023 Category: Drugs & Pharmacology Authors: Elena Kalinichenko Svetlana Babitskaya Source Type: research

Biological Potential and Therapeutic Effectiveness of Geiparvarin in Medicine for its Anti-proliferative Activity against Tumors and Other Human Complications
Curr Drug Targets. 2023 Nov 30. doi: 10.2174/0113894501271142231120065852. Online ahead of print.NO ABSTRACTPMID:38037997 | DOI:10.2174/0113894501271142231120065852 (Source: Current Drug Targets)
Source: Current Drug Targets - December 1, 2023 Category: Drugs & Pharmacology Authors: Dinesh Kumar Patel Source Type: research

Deciphering the Function of New Therapeutic Targets and Prospective Biomarkers in the Management of Psoriasis
Curr Drug Targets. 2023 Nov 30. doi: 10.2174/0113894501277656231128060242. Online ahead of print.ABSTRACTPsoriasis is an immune-mediated skin condition affecting people worldwide, presenting at any age, and leading to a substantial burden physically and mentally. The innate and adaptive immune systems interact intricately with the pathomechanisms that underlie disease. T cells can interact with keratinocytes, macrophages, and dendritic cells through the cytokines they secrete. According to recent research, psoriasis flare-ups can cause systemic inflammation and various other co-morbidities, including depression, psoriatic ...
Source: Current Drug Targets - December 1, 2023 Category: Drugs & Pharmacology Authors: Japneet Singh Purewal Gaurav Mahesh Doshi Source Type: research

Antiviral Potential of Traditional Unani Medicine in Viral Diseases with Special Emphasis on Dengue: A Review
Curr Drug Targets. 2023 Nov 21. doi: 10.2174/0113894501257577231103044735. Online ahead of print.ABSTRACTDengue fever has become a major public health concern. It is usually related to intravascular leaking, bleeding disorders, and thrombocytopenia and is recognized as a potent threat to humans. The scarcity of anti-dengue medication or vaccine for such a serious disease leads to an upsurge in the usage of traditional medicines for its proper management. India has diverse biodiversity and a long history of using plant-based remedies. Several medicinal plant extracts have been studied for producing anti-dengue viral activit...
Source: Current Drug Targets - December 1, 2023 Category: Drugs & Pharmacology Authors: Muzayyana Khan Mohammad Altamish Monalisha Samal Varsha Srivastava Areeba Insaf Rabea Parveen Jamal Akhtar Anuja Krishnan Sayeed Ahmad Source Type: research