Tebentafusp as a Promising Drug for the Treatment of Uveal Melanoma
Curr Drug Targets. 2023 Dec 19. doi: 10.2174/0113894501280380231214105255. Online ahead of print.ABSTRACTUveal melanoma (UM) is the most common primary intraocular malignancy in adults and commonly occurs in the Caucasian population. The malignancy involves the uvea of the eye, which includes the iris, ciliary body, and choroid. The etiology of UM is still not well understood, but age is a risk factor. Symptoms include blurred vision, redness of the eye, floaters, dark spots, a change in the size of the pupil, and loss of vision. The location, shape, and size of the tumor are important for therapeutic purposes. Treating me...
Source: Current Drug Targets - December 20, 2023 Category: Drugs & Pharmacology Authors: Khalid Al Balushi Abdulrahman Al Hadhrami Hamdan Al Balushi Srijit Das Abdullah Al Lawati Source Type: research
An Update on the Emerging Role of Wnt/ β-catenin, SYK, PI3K/AKT, and GM-CSF Signaling Pathways in Rheumatoid Arthritis
Curr Drug Targets. 2023 Dec 11. doi: 10.2174/0113894501276093231206064243. Online ahead of print.ABSTRACTRheumatoid arthritis is an untreatable autoimmune disorder. The disease is accompanied by joint impairment and anomalies, which negatively affect the patient's quality of life and contribute to a decline in manpower. To diagnose and treat rheumatoid arthritis, it is crucial to understand the abnormal signaling pathways that contribute to the disease. This understanding will help develop new rheumatoid arthritis-related intervention targets. Over the last few decades, researchers have given more attention to rheumatoid a...
Source: Current Drug Targets - December 12, 2023 Category: Drugs & Pharmacology Authors: Pradyuman Prajapati Gaurav Doshi Source Type: research
An Update on the Emerging Role of Wnt/ β-catenin, SYK, PI3K/AKT, and GM-CSF Signaling Pathways in Rheumatoid Arthritis
Curr Drug Targets. 2023 Dec 11. doi: 10.2174/0113894501276093231206064243. Online ahead of print.ABSTRACTRheumatoid arthritis is an untreatable autoimmune disorder. The disease is accompanied by joint impairment and anomalies, which negatively affect the patient's quality of life and contribute to a decline in manpower. To diagnose and treat rheumatoid arthritis, it is crucial to understand the abnormal signaling pathways that contribute to the disease. This understanding will help develop new rheumatoid arthritis-related intervention targets. Over the last few decades, researchers have given more attention to rheumatoid a...
Source: Current Drug Targets - December 12, 2023 Category: Drugs & Pharmacology Authors: Pradyuman Prajapati Gaurav Doshi Source Type: research
An Update on the Emerging Role of Wnt/ β-catenin, SYK, PI3K/AKT, and GM-CSF Signaling Pathways in Rheumatoid Arthritis
Curr Drug Targets. 2023 Dec 11. doi: 10.2174/0113894501276093231206064243. Online ahead of print.ABSTRACTRheumatoid arthritis is an untreatable autoimmune disorder. The disease is accompanied by joint impairment and anomalies, which negatively affect the patient's quality of life and contribute to a decline in manpower. To diagnose and treat rheumatoid arthritis, it is crucial to understand the abnormal signaling pathways that contribute to the disease. This understanding will help develop new rheumatoid arthritis-related intervention targets. Over the last few decades, researchers have given more attention to rheumatoid a...
Source: Current Drug Targets - December 12, 2023 Category: Drugs & Pharmacology Authors: Pradyuman Prajapati Gaurav Doshi Source Type: research
An Update on the Emerging Role of Wnt/ β-catenin, SYK, PI3K/AKT, and GM-CSF Signaling Pathways in Rheumatoid Arthritis
Curr Drug Targets. 2023 Dec 11. doi: 10.2174/0113894501276093231206064243. Online ahead of print.ABSTRACTRheumatoid arthritis is an untreatable autoimmune disorder. The disease is accompanied by joint impairment and anomalies, which negatively affect the patient's quality of life and contribute to a decline in manpower. To diagnose and treat rheumatoid arthritis, it is crucial to understand the abnormal signaling pathways that contribute to the disease. This understanding will help develop new rheumatoid arthritis-related intervention targets. Over the last few decades, researchers have given more attention to rheumatoid a...
Source: Current Drug Targets - December 12, 2023 Category: Drugs & Pharmacology Authors: Pradyuman Prajapati Gaurav Doshi Source Type: research
An Update on the Emerging Role of Wnt/ β-catenin, SYK, PI3K/AKT, and GM-CSF Signaling Pathways in Rheumatoid Arthritis
Curr Drug Targets. 2023 Dec 11. doi: 10.2174/0113894501276093231206064243. Online ahead of print.ABSTRACTRheumatoid arthritis is an untreatable autoimmune disorder. The disease is accompanied by joint impairment and anomalies, which negatively affect the patient's quality of life and contribute to a decline in manpower. To diagnose and treat rheumatoid arthritis, it is crucial to understand the abnormal signaling pathways that contribute to the disease. This understanding will help develop new rheumatoid arthritis-related intervention targets. Over the last few decades, researchers have given more attention to rheumatoid a...
Source: Current Drug Targets - December 12, 2023 Category: Drugs & Pharmacology Authors: Pradyuman Prajapati Gaurav Doshi Source Type: research
An Update on the Emerging Role of Wnt/ β-catenin, SYK, PI3K/AKT, and GM-CSF Signaling Pathways in Rheumatoid Arthritis
Curr Drug Targets. 2023 Dec 11. doi: 10.2174/0113894501276093231206064243. Online ahead of print.ABSTRACTRheumatoid arthritis is an untreatable autoimmune disorder. The disease is accompanied by joint impairment and anomalies, which negatively affect the patient's quality of life and contribute to a decline in manpower. To diagnose and treat rheumatoid arthritis, it is crucial to understand the abnormal signaling pathways that contribute to the disease. This understanding will help develop new rheumatoid arthritis-related intervention targets. Over the last few decades, researchers have given more attention to rheumatoid a...
Source: Current Drug Targets - December 12, 2023 Category: Drugs & Pharmacology Authors: Pradyuman Prajapati Gaurav Doshi Source Type: research
Recent Progress and Challenges in Clinical Translation of Nanomedicines in Diagnosis and Treatment of Lung Cancer
Curr Drug Targets. 2023 Dec 6. doi: 10.2174/0113894501273651231201061144. Online ahead of print.ABSTRACTLung cancer is one of the leading causes of death across the world. There are numerous challenges in the early diagnosis and effective treatment of lung cancer, including developing multidrug resistance. However, the diagnosis of lung cancer could be minimally invasive or non-invasive. Nowadays, nanomedicines offer solutions to several emerging challenges in drug delivery research areas. It has the potential to enhance the therapeutic efficacy of biologically and chemically active agents at the site of action. This appro...
Source: Current Drug Targets - December 7, 2023 Category: Drugs & Pharmacology Authors: Bhavna Yadav Mahima Chauhan Rahul Pratap Singh None Sonali Saurabh Shekhar Source Type: research
Recent Progress and Challenges in Clinical Translation of Nanomedicines in Diagnosis and Treatment of Lung Cancer
Curr Drug Targets. 2023 Dec 6. doi: 10.2174/0113894501273651231201061144. Online ahead of print.ABSTRACTLung cancer is one of the leading causes of death across the world. There are numerous challenges in the early diagnosis and effective treatment of lung cancer, including developing multidrug resistance. However, the diagnosis of lung cancer could be minimally invasive or non-invasive. Nowadays, nanomedicines offer solutions to several emerging challenges in drug delivery research areas. It has the potential to enhance the therapeutic efficacy of biologically and chemically active agents at the site of action. This appro...
Source: Current Drug Targets - December 7, 2023 Category: Drugs & Pharmacology Authors: Bhavna Yadav Mahima Chauhan Rahul Pratap Singh None Sonali Saurabh Shekhar Source Type: research
Recent Progress and Challenges in Clinical Translation of Nanomedicines in Diagnosis and Treatment of Lung Cancer
Curr Drug Targets. 2023 Dec 6. doi: 10.2174/0113894501273651231201061144. Online ahead of print.ABSTRACTLung cancer is one of the leading causes of death across the world. There are numerous challenges in the early diagnosis and effective treatment of lung cancer, including developing multidrug resistance. However, the diagnosis of lung cancer could be minimally invasive or non-invasive. Nowadays, nanomedicines offer solutions to several emerging challenges in drug delivery research areas. It has the potential to enhance the therapeutic efficacy of biologically and chemically active agents at the site of action. This appro...
Source: Current Drug Targets - December 7, 2023 Category: Drugs & Pharmacology Authors: Bhavna Yadav Mahima Chauhan Rahul Pratap Singh None Sonali Saurabh Shekhar Source Type: research
Recent Progress and Challenges in Clinical Translation of Nanomedicines in Diagnosis and Treatment of Lung Cancer
Curr Drug Targets. 2023 Dec 6. doi: 10.2174/0113894501273651231201061144. Online ahead of print.ABSTRACTLung cancer is one of the leading causes of death across the world. There are numerous challenges in the early diagnosis and effective treatment of lung cancer, including developing multidrug resistance. However, the diagnosis of lung cancer could be minimally invasive or non-invasive. Nowadays, nanomedicines offer solutions to several emerging challenges in drug delivery research areas. It has the potential to enhance the therapeutic efficacy of biologically and chemically active agents at the site of action. This appro...
Source: Current Drug Targets - December 7, 2023 Category: Drugs & Pharmacology Authors: Bhavna Yadav Mahima Chauhan Rahul Pratap Singh None Sonali Saurabh Shekhar Source Type: research
Recent Progress and Challenges in Clinical Translation of Nanomedicines in Diagnosis and Treatment of Lung Cancer
Curr Drug Targets. 2023 Dec 6. doi: 10.2174/0113894501273651231201061144. Online ahead of print.ABSTRACTLung cancer is one of the leading causes of death across the world. There are numerous challenges in the early diagnosis and effective treatment of lung cancer, including developing multidrug resistance. However, the diagnosis of lung cancer could be minimally invasive or non-invasive. Nowadays, nanomedicines offer solutions to several emerging challenges in drug delivery research areas. It has the potential to enhance the therapeutic efficacy of biologically and chemically active agents at the site of action. This appro...
Source: Current Drug Targets - December 7, 2023 Category: Drugs & Pharmacology Authors: Bhavna Yadav Mahima Chauhan Rahul Pratap Singh None Sonali Saurabh Shekhar Source Type: research
Therapeutic Potential of Targeting Transforming Growth Factor-beta (TGF- β) and Programmed Death-ligand 1 (PD-L1) in Pancreatic Cancer
Curr Drug Targets. 2023 Dec 5. doi: 10.2174/0113894501264450231129042256. Online ahead of print.ABSTRACTPancreatic cancer (PC) is one the most lethal malignancies worldwide affecting around half a million individuals each year. The treatment of PC is relatively difficult due to the difficulty in making an early diagnosis. Transforming growth factor-beta (TGF-β) is a multifunctional factor acting as both a tumor promoter in early cancer stages and a tumor suppressor in advanced disease. Programmed death-ligand 1 (PD-L1) is a ligand of programmed death-1 (PD-1), an immune checkpoint receptor, allowing tumor cells to avoid e...
Source: Current Drug Targets - December 6, 2023 Category: Drugs & Pharmacology Authors: Ghazaleh Pourali Nima Zafari Mahla Velayati Shima Mehrabadi Mina Maftooh Seyed Mahdi Hassanian Majid Ghayour-Mobarhan Gordon A Ferns Amir Avan Majid Khazaei Source Type: research
An Outbreak of Eye Flu Virus in India
Curr Drug Targets. 2023 Dec 5. doi: 10.2174/0113894501275247231129112022. Online ahead of print.NO ABSTRACTPMID:38053356 | DOI:10.2174/0113894501275247231129112022 (Source: Current Drug Targets)
Source: Current Drug Targets - December 6, 2023 Category: Drugs & Pharmacology Authors: Raj Kamal Debanjan Mukherjee Amandeep Singh Source Type: research
Antiviral Potential of Traditional Unani Medicine in Viral Diseases with Special Emphasis on Dengue: A Review
Curr Drug Targets. 2023 Nov 21. doi: 10.2174/0113894501257577231103044735. Online ahead of print.ABSTRACTDengue fever has become a major public health concern. It is usually related to intravascular leaking, bleeding disorders, and thrombocytopenia and is recognized as a potent threat to humans. The scarcity of anti-dengue medication or vaccine for such a serious disease leads to an upsurge in the usage of traditional medicines for its proper management. India has diverse biodiversity and a long history of using plant-based remedies. Several medicinal plant extracts have been studied for producing anti-dengue viral activit...
Source: Current Drug Targets - December 1, 2023 Category: Drugs & Pharmacology Authors: Muzayyana Khan Mohammad Altamish Monalisha Samal Varsha Srivastava Areeba Insaf Rabea Parveen Jamal Akhtar Anuja Krishnan Sayeed Ahmad Source Type: research
