Redox interactions in chemo/radiation therapy-induced lung toxicity; mechanisms and therapy perspectives
Curr Drug Targets. 2022 Jul 5. doi: 10.2174/1389450123666220705123315. Online ahead of print.ABSTRACTLung toxicity is a key limiting factor for the therapy of cancer, especially lung, breast, and esophageal malignancies. Radiotherapy for chest and breast malignancies can cause lung injury. However, systemic cancer therapy with chemotherapy also may induce lung pneumonitis and fibrosis. Radiotherapy produces reactive oxygen species (ROS) directly via interacting with water molecules within cells. However, radiation and other therapy modalities may induce the endogenous generation of ROS and nitric oxide (NO) by immune cells...
Source: Current Drug Targets - July 6, 2022 Category: Drugs & Pharmacology Authors: Xixi Lai Masoud Najafi Source Type: research

Redox interactions in chemo/radiation therapy-induced lung toxicity; mechanisms and therapy perspectives
Curr Drug Targets. 2022 Jul 5. doi: 10.2174/1389450123666220705123315. Online ahead of print.ABSTRACTLung toxicity is a key limiting factor for the therapy of cancer, especially lung, breast, and esophageal malignancies. Radiotherapy for chest and breast malignancies can cause lung injury. However, systemic cancer therapy with chemotherapy also may induce lung pneumonitis and fibrosis. Radiotherapy produces reactive oxygen species (ROS) directly via interacting with water molecules within cells. However, radiation and other therapy modalities may induce the endogenous generation of ROS and nitric oxide (NO) by immune cells...
Source: Current Drug Targets - July 6, 2022 Category: Drugs & Pharmacology Authors: Xixi Lai Masoud Najafi Source Type: research

Redox interactions in chemo/radiation therapy-induced lung toxicity; mechanisms and therapy perspectives
Curr Drug Targets. 2022 Jul 5. doi: 10.2174/1389450123666220705123315. Online ahead of print.ABSTRACTLung toxicity is a key limiting factor for the therapy of cancer, especially lung, breast, and esophageal malignancies. Radiotherapy for chest and breast malignancies can cause lung injury. However, systemic cancer therapy with chemotherapy also may induce lung pneumonitis and fibrosis. Radiotherapy produces reactive oxygen species (ROS) directly via interacting with water molecules within cells. However, radiation and other therapy modalities may induce the endogenous generation of ROS and nitric oxide (NO) by immune cells...
Source: Current Drug Targets - July 6, 2022 Category: Drugs & Pharmacology Authors: Xixi Lai Masoud Najafi Source Type: research

Redox interactions in chemo/radiation therapy-induced lung toxicity; mechanisms and therapy perspectives
Curr Drug Targets. 2022 Jul 5. doi: 10.2174/1389450123666220705123315. Online ahead of print.ABSTRACTLung toxicity is a key limiting factor for the therapy of cancer, especially lung, breast, and esophageal malignancies. Radiotherapy for chest and breast malignancies can cause lung injury. However, systemic cancer therapy with chemotherapy also may induce lung pneumonitis and fibrosis. Radiotherapy produces reactive oxygen species (ROS) directly via interacting with water molecules within cells. However, radiation and other therapy modalities may induce the endogenous generation of ROS and nitric oxide (NO) by immune cells...
Source: Current Drug Targets - July 6, 2022 Category: Drugs & Pharmacology Authors: Xixi Lai Masoud Najafi Source Type: research

Redox interactions in chemo/radiation therapy-induced lung toxicity; mechanisms and therapy perspectives
Curr Drug Targets. 2022 Jul 5. doi: 10.2174/1389450123666220705123315. Online ahead of print.ABSTRACTLung toxicity is a key limiting factor for the therapy of cancer, especially lung, breast, and esophageal malignancies. Radiotherapy for chest and breast malignancies can cause lung injury. However, systemic cancer therapy with chemotherapy also may induce lung pneumonitis and fibrosis. Radiotherapy produces reactive oxygen species (ROS) directly via interacting with water molecules within cells. However, radiation and other therapy modalities may induce the endogenous generation of ROS and nitric oxide (NO) by immune cells...
Source: Current Drug Targets - July 6, 2022 Category: Drugs & Pharmacology Authors: Xixi Lai Masoud Najafi Source Type: research

Redox interactions in chemo/radiation therapy-induced lung toxicity; mechanisms and therapy perspectives
Curr Drug Targets. 2022 Jul 5. doi: 10.2174/1389450123666220705123315. Online ahead of print.ABSTRACTLung toxicity is a key limiting factor for the therapy of cancer, especially lung, breast, and esophageal malignancies. Radiotherapy for chest and breast malignancies can cause lung injury. However, systemic cancer therapy with chemotherapy also may induce lung pneumonitis and fibrosis. Radiotherapy produces reactive oxygen species (ROS) directly via interacting with water molecules within cells. However, radiation and other therapy modalities may induce the endogenous generation of ROS and nitric oxide (NO) by immune cells...
Source: Current Drug Targets - July 6, 2022 Category: Drugs & Pharmacology Authors: Xixi Lai Masoud Najafi Source Type: research

Redox interactions in chemo/radiation therapy-induced lung toxicity; mechanisms and therapy perspectives
Curr Drug Targets. 2022 Jul 5. doi: 10.2174/1389450123666220705123315. Online ahead of print.ABSTRACTLung toxicity is a key limiting factor for the therapy of cancer, especially lung, breast, and esophageal malignancies. Radiotherapy for chest and breast malignancies can cause lung injury. However, systemic cancer therapy with chemotherapy also may induce lung pneumonitis and fibrosis. Radiotherapy produces reactive oxygen species (ROS) directly via interacting with water molecules within cells. However, radiation and other therapy modalities may induce the endogenous generation of ROS and nitric oxide (NO) by immune cells...
Source: Current Drug Targets - July 6, 2022 Category: Drugs & Pharmacology Authors: Xixi Lai Masoud Najafi Source Type: research

Redox interactions in chemo/radiation therapy-induced lung toxicity; mechanisms and therapy perspectives
Curr Drug Targets. 2022 Jul 5. doi: 10.2174/1389450123666220705123315. Online ahead of print.ABSTRACTLung toxicity is a key limiting factor for the therapy of cancer, especially lung, breast, and esophageal malignancies. Radiotherapy for chest and breast malignancies can cause lung injury. However, systemic cancer therapy with chemotherapy also may induce lung pneumonitis and fibrosis. Radiotherapy produces reactive oxygen species (ROS) directly via interacting with water molecules within cells. However, radiation and other therapy modalities may induce the endogenous generation of ROS and nitric oxide (NO) by immune cells...
Source: Current Drug Targets - July 6, 2022 Category: Drugs & Pharmacology Authors: Xixi Lai Masoud Najafi Source Type: research

Redox interactions in chemo/radiation therapy-induced lung toxicity; mechanisms and therapy perspectives
Curr Drug Targets. 2022 Jul 5. doi: 10.2174/1389450123666220705123315. Online ahead of print.ABSTRACTLung toxicity is a key limiting factor for the therapy of cancer, especially lung, breast, and esophageal malignancies. Radiotherapy for chest and breast malignancies can cause lung injury. However, systemic cancer therapy with chemotherapy also may induce lung pneumonitis and fibrosis. Radiotherapy produces reactive oxygen species (ROS) directly via interacting with water molecules within cells. However, radiation and other therapy modalities may induce the endogenous generation of ROS and nitric oxide (NO) by immune cells...
Source: Current Drug Targets - July 6, 2022 Category: Drugs & Pharmacology Authors: Xixi Lai Masoud Najafi Source Type: research

Redox interactions in chemo/radiation therapy-induced lung toxicity; mechanisms and therapy perspectives
Curr Drug Targets. 2022 Jul 5. doi: 10.2174/1389450123666220705123315. Online ahead of print.ABSTRACTLung toxicity is a key limiting factor for the therapy of cancer, especially lung, breast, and esophageal malignancies. Radiotherapy for chest and breast malignancies can cause lung injury. However, systemic cancer therapy with chemotherapy also may induce lung pneumonitis and fibrosis. Radiotherapy produces reactive oxygen species (ROS) directly via interacting with water molecules within cells. However, radiation and other therapy modalities may induce the endogenous generation of ROS and nitric oxide (NO) by immune cells...
Source: Current Drug Targets - July 6, 2022 Category: Drugs & Pharmacology Authors: Xixi Lai Masoud Najafi Source Type: research

Redox interactions in chemo/radiation therapy-induced lung toxicity; mechanisms and therapy perspectives
Curr Drug Targets. 2022 Jul 5. doi: 10.2174/1389450123666220705123315. Online ahead of print.ABSTRACTLung toxicity is a key limiting factor for the therapy of cancer, especially lung, breast, and esophageal malignancies. Radiotherapy for chest and breast malignancies can cause lung injury. However, systemic cancer therapy with chemotherapy also may induce lung pneumonitis and fibrosis. Radiotherapy produces reactive oxygen species (ROS) directly via interacting with water molecules within cells. However, radiation and other therapy modalities may induce the endogenous generation of ROS and nitric oxide (NO) by immune cells...
Source: Current Drug Targets - July 6, 2022 Category: Drugs & Pharmacology Authors: Xixi Lai Masoud Najafi Source Type: research

Redox interactions in chemo/radiation therapy-induced lung toxicity; mechanisms and therapy perspectives
Curr Drug Targets. 2022 Jul 5. doi: 10.2174/1389450123666220705123315. Online ahead of print.ABSTRACTLung toxicity is a key limiting factor for the therapy of cancer, especially lung, breast, and esophageal malignancies. Radiotherapy for chest and breast malignancies can cause lung injury. However, systemic cancer therapy with chemotherapy also may induce lung pneumonitis and fibrosis. Radiotherapy produces reactive oxygen species (ROS) directly via interacting with water molecules within cells. However, radiation and other therapy modalities may induce the endogenous generation of ROS and nitric oxide (NO) by immune cells...
Source: Current Drug Targets - July 6, 2022 Category: Drugs & Pharmacology Authors: Xixi Lai Masoud Najafi Source Type: research

Redox interactions in chemo/radiation therapy-induced lung toxicity; mechanisms and therapy perspectives
Curr Drug Targets. 2022 Jul 5. doi: 10.2174/1389450123666220705123315. Online ahead of print.ABSTRACTLung toxicity is a key limiting factor for the therapy of cancer, especially lung, breast, and esophageal malignancies. Radiotherapy for chest and breast malignancies can cause lung injury. However, systemic cancer therapy with chemotherapy also may induce lung pneumonitis and fibrosis. Radiotherapy produces reactive oxygen species (ROS) directly via interacting with water molecules within cells. However, radiation and other therapy modalities may induce the endogenous generation of ROS and nitric oxide (NO) by immune cells...
Source: Current Drug Targets - July 6, 2022 Category: Drugs & Pharmacology Authors: Xixi Lai Masoud Najafi Source Type: research

Redox interactions in chemo/radiation therapy-induced lung toxicity; mechanisms and therapy perspectives
Curr Drug Targets. 2022 Jul 5. doi: 10.2174/1389450123666220705123315. Online ahead of print.ABSTRACTLung toxicity is a key limiting factor for the therapy of cancer, especially lung, breast, and esophageal malignancies. Radiotherapy for chest and breast malignancies can cause lung injury. However, systemic cancer therapy with chemotherapy also may induce lung pneumonitis and fibrosis. Radiotherapy produces reactive oxygen species (ROS) directly via interacting with water molecules within cells. However, radiation and other therapy modalities may induce the endogenous generation of ROS and nitric oxide (NO) by immune cells...
Source: Current Drug Targets - July 6, 2022 Category: Drugs & Pharmacology Authors: Xixi Lai Masoud Najafi Source Type: research

Cellular Therapeutics for Chronic Wound healing: Future for Regenerative Medicine
Curr Drug Targets. 2022 Jun 23. doi: 10.2174/138945012309220623144620. Online ahead of print.ABSTRACTChronic wounds are associated with significant morbidity and mortality which demands long-term effective treatment and represents a tremendous financial strain on the global healthcare systems. Regenerative medicines using stem cells have recently become apparent as a promising approach and are an active zone of investigations they hold the potential to differentiate into specific types of cells and thus possess self-renewable, regenerative, and immune-modulatory effects. Furthermore, with the rise of technology various cel...
Source: Current Drug Targets - June 24, 2022 Category: Drugs & Pharmacology Authors: Preety Sharma Arun Kumar Asmita Deka Dey Source Type: research