A Review on the Recent Advancements and Artificial Intelligence in Tablet Technology
CONCLUSION: The integration of nanotechnology, AI, ML, and materials science with traditional pharmaceutical sciences presents a remarkable opportunity for enhancing tablet formulation processes. This review collectively underscores the transformative role that AI and ML can play in advancing pharmaceutical research and development, ultimately leading to more efficient, reliable and patient-centric tablet formulations.PMID:38213164 | DOI:10.2174/0113894501281290231221053939 (Source: Current Drug Targets)
Source: Current Drug Targets - January 12, 2024 Category: Drugs & Pharmacology Authors: Amit Sahu Sunny Rathee Shivani Saraf Sanjay K Jain Source Type: research

Efficacy and Possible Mechanisms of Astragali Radix and its Ingredients in Animal Models of Osteoporosis: A Preclinical Review and Metaanalysis
CONCLUSION: The findings suggest the possibility of developing IAR as a drug for the treatment of OP. IAR with longer treatment time may achieve better effects regardless of animal strain and age.PMID:38213165 | DOI:10.2174/0113894501275292231220062838 (Source: Current Drug Targets)
Source: Current Drug Targets - January 12, 2024 Category: Drugs & Pharmacology Authors: Ning Cao Zhangxuan Shou Yi Xiao Puqing Liu Source Type: research

Bile Acid Application in Cell-Targeting for Molecular Receptors in Relation to Hearing: A Comprehensive Review
Curr Drug Targets. 2024 Jan 8. doi: 10.2174/0113894501278292231223035733. Online ahead of print.ABSTRACTBile acids play important roles in the human body, and changes in their pool can be used as markers for various liver pathologies. In addition to their functional effects in modulating inflammatory responses and cellular survivability, the unconjugated or conjugated, secondary, or primary nature of bile acids accounts for their various ligand effects. The common hydrophilic bile acids have been used successfully as local treatment to resolve drug-induced cell damage or to ameliorate hearing loss. From various literature ...
Source: Current Drug Targets - January 9, 2024 Category: Drugs & Pharmacology Authors: Corina M Ionescu Melissa A Jones Susbin R Wagle Bozica Kovacevic Thomas Foste Momir Mikov Armin Mooranian Hani Al-Salami Source Type: research

Bile Acid Application in Cell-Targeting for Molecular Receptors in Relation to Hearing: A Comprehensive Review
Curr Drug Targets. 2024 Jan 8. doi: 10.2174/0113894501278292231223035733. Online ahead of print.ABSTRACTBile acids play important roles in the human body, and changes in their pool can be used as markers for various liver pathologies. In addition to their functional effects in modulating inflammatory responses and cellular survivability, the unconjugated or conjugated, secondary, or primary nature of bile acids accounts for their various ligand effects. The common hydrophilic bile acids have been used successfully as local treatment to resolve drug-induced cell damage or to ameliorate hearing loss. From various literature ...
Source: Current Drug Targets - January 9, 2024 Category: Drugs & Pharmacology Authors: Corina M Ionescu Melissa A Jones Susbin R Wagle Bozica Kovacevic Thomas Foste Momir Mikov Armin Mooranian Hani Al-Salami Source Type: research

Deciphering the Role of Pyroptosis Impact on Cardiovascular Diseases
Curr Drug Targets. 2023;24(15):1166-1183. doi: 10.2174/0113894501267496231102114410.ABSTRACTPyroptosis has become a noteworthy area of focus in recent years due to its association with inflammatory diseases. Pyroptosis is a type of programmed cell death accompanied by an inflammatory response, and the discovery of the gasdermin family has expanded the study of pyroptosis. The primary characteristics of pyroptosis include cell expansion, membrane penetration, and the ejection of cell contents. In healthy physiology, pyroptosis is an essential part of the host's defence against pathogen infection. Excessive Pyroptosis, howev...
Source: Current Drug Targets - January 2, 2024 Category: Drugs & Pharmacology Authors: Poonam Patil Gaurav Doshi Source Type: research

Biomarkers and Treatment Strategies for Breast Cancer Recurrence
This article aimed to summarise the primary causes of breast cancer recurrence and highlight the key issues that need to be addressed in order to effectively decrease the mortality rate among breast cancer patients. This article discusses various therapeutic approaches currently employed and emerging treatment strategies that hold the potential for the complete cure of cancer.PMID:38164731 | DOI:10.2174/0113894501258059231103072025 (Source: Current Drug Targets)
Source: Current Drug Targets - January 2, 2024 Category: Drugs & Pharmacology Authors: Shivam Rajput Pramod Kumar Sharma Rishabha Malviya Source Type: research

Deciphering the Role of Pyroptosis Impact on Cardiovascular Diseases
Curr Drug Targets. 2023;24(15):1166-1183. doi: 10.2174/0113894501267496231102114410.ABSTRACTPyroptosis has become a noteworthy area of focus in recent years due to its association with inflammatory diseases. Pyroptosis is a type of programmed cell death accompanied by an inflammatory response, and the discovery of the gasdermin family has expanded the study of pyroptosis. The primary characteristics of pyroptosis include cell expansion, membrane penetration, and the ejection of cell contents. In healthy physiology, pyroptosis is an essential part of the host's defence against pathogen infection. Excessive Pyroptosis, howev...
Source: Current Drug Targets - January 2, 2024 Category: Drugs & Pharmacology Authors: Poonam Patil Gaurav Doshi Source Type: research

Biomarkers and Treatment Strategies for Breast Cancer Recurrence
This article aimed to summarise the primary causes of breast cancer recurrence and highlight the key issues that need to be addressed in order to effectively decrease the mortality rate among breast cancer patients. This article discusses various therapeutic approaches currently employed and emerging treatment strategies that hold the potential for the complete cure of cancer.PMID:38164731 | DOI:10.2174/0113894501258059231103072025 (Source: Current Drug Targets)
Source: Current Drug Targets - January 2, 2024 Category: Drugs & Pharmacology Authors: Shivam Rajput Pramod Kumar Sharma Rishabha Malviya Source Type: research

Deciphering the Role of Pyroptosis Impact on Cardiovascular Diseases
Curr Drug Targets. 2023;24(15):1166-1183. doi: 10.2174/0113894501267496231102114410.ABSTRACTPyroptosis has become a noteworthy area of focus in recent years due to its association with inflammatory diseases. Pyroptosis is a type of programmed cell death accompanied by an inflammatory response, and the discovery of the gasdermin family has expanded the study of pyroptosis. The primary characteristics of pyroptosis include cell expansion, membrane penetration, and the ejection of cell contents. In healthy physiology, pyroptosis is an essential part of the host's defence against pathogen infection. Excessive Pyroptosis, howev...
Source: Current Drug Targets - January 2, 2024 Category: Drugs & Pharmacology Authors: Poonam Patil Gaurav Doshi Source Type: research

Biomarkers and Treatment Strategies for Breast Cancer Recurrence
This article aimed to summarise the primary causes of breast cancer recurrence and highlight the key issues that need to be addressed in order to effectively decrease the mortality rate among breast cancer patients. This article discusses various therapeutic approaches currently employed and emerging treatment strategies that hold the potential for the complete cure of cancer.PMID:38164731 | DOI:10.2174/0113894501258059231103072025 (Source: Current Drug Targets)
Source: Current Drug Targets - January 2, 2024 Category: Drugs & Pharmacology Authors: Shivam Rajput Pramod Kumar Sharma Rishabha Malviya Source Type: research

Deciphering the Role of Pyroptosis Impact on Cardiovascular Diseases
Curr Drug Targets. 2023;24(15):1166-1183. doi: 10.2174/0113894501267496231102114410.ABSTRACTPyroptosis has become a noteworthy area of focus in recent years due to its association with inflammatory diseases. Pyroptosis is a type of programmed cell death accompanied by an inflammatory response, and the discovery of the gasdermin family has expanded the study of pyroptosis. The primary characteristics of pyroptosis include cell expansion, membrane penetration, and the ejection of cell contents. In healthy physiology, pyroptosis is an essential part of the host's defence against pathogen infection. Excessive Pyroptosis, howev...
Source: Current Drug Targets - January 2, 2024 Category: Drugs & Pharmacology Authors: Poonam Patil Gaurav Doshi Source Type: research

Biomarkers and Treatment Strategies for Breast Cancer Recurrence
This article aimed to summarise the primary causes of breast cancer recurrence and highlight the key issues that need to be addressed in order to effectively decrease the mortality rate among breast cancer patients. This article discusses various therapeutic approaches currently employed and emerging treatment strategies that hold the potential for the complete cure of cancer.PMID:38164731 | DOI:10.2174/0113894501258059231103072025 (Source: Current Drug Targets)
Source: Current Drug Targets - January 2, 2024 Category: Drugs & Pharmacology Authors: Shivam Rajput Pramod Kumar Sharma Rishabha Malviya Source Type: research

Deciphering the Role of Pyroptosis Impact on Cardiovascular Diseases
Curr Drug Targets. 2023;24(15):1166-1183. doi: 10.2174/0113894501267496231102114410.ABSTRACTPyroptosis has become a noteworthy area of focus in recent years due to its association with inflammatory diseases. Pyroptosis is a type of programmed cell death accompanied by an inflammatory response, and the discovery of the gasdermin family has expanded the study of pyroptosis. The primary characteristics of pyroptosis include cell expansion, membrane penetration, and the ejection of cell contents. In healthy physiology, pyroptosis is an essential part of the host's defence against pathogen infection. Excessive Pyroptosis, howev...
Source: Current Drug Targets - January 2, 2024 Category: Drugs & Pharmacology Authors: Poonam Patil Gaurav Doshi Source Type: research

Biomarkers and Treatment Strategies for Breast Cancer Recurrence
This article aimed to summarise the primary causes of breast cancer recurrence and highlight the key issues that need to be addressed in order to effectively decrease the mortality rate among breast cancer patients. This article discusses various therapeutic approaches currently employed and emerging treatment strategies that hold the potential for the complete cure of cancer.PMID:38164731 | DOI:10.2174/0113894501258059231103072025 (Source: Current Drug Targets)
Source: Current Drug Targets - January 2, 2024 Category: Drugs & Pharmacology Authors: Shivam Rajput Pramod Kumar Sharma Rishabha Malviya Source Type: research

Rho Kinase (ROCK) Inhibitors for the Treatment of Glaucoma
Curr Drug Targets. 2023 Dec 28. doi: 10.2174/0113894501286195231220094646. Online ahead of print.ABSTRACTGlaucoma is the most common cause of irreversible blindness worldwide. It is characterized by progressive optic nerve degeneration and loss of visual field. Pathological increased intraocular pressure is its main modifiable risk factor. Rho kinase inhibitors are developed as a new class of glaucoma medication that increases outflow facility from the conventional aqueous humor outflow pathway. Additionally, they also have neuropective and anti-scarring effects that can might increase the success rate of glaucoma filtrati...
Source: Current Drug Targets - December 29, 2023 Category: Drugs & Pharmacology Authors: Junhui Wu Jing Wei Haoliang Chen Yalong Dang Fang Lei Source Type: research