Syndecan-1: A Novel Diagnostic and Therapeutic Target in Liver Diseases
Curr Drug Targets. 2023 Nov 7. doi: 10.2174/0113894501250057231102061624. Online ahead of print.ABSTRACTSyndecan-1 (SDC-1), known as a coreceptor of various growth factors or an integrin binding partner, regulates various cell behaviours. Under certain pathological conditions, SDC-1 is shed from the cell surface and plays a protective or pathogenic role in various diseases. In the liver, SDC-1 is highly expressed in hepatocytes, where it is localized on the basolateral surface. It is critical to the cellular and molecular functions of hepatocytes, including their attachment to hepatitis viruses. Previous studies have repor...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Yingli He Xiaoli Zhang Yalei Zhao Liangru Liu Source Type: research

Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing
Curr Drug Targets. 2023 Nov 9. doi: 10.2174/0113894501260002231101080505. Online ahead of print.ABSTRACTThe diabetic wound is excessively vulnerable to infection because the diabetic wound suggests delayed and incomplete healing techniques. Presently, wounds and ulcers related to diabetes have additionally increased the medical burden. A diabetic wound can impair mobility, lead to amputations, or even death. In recent times, advanced drug delivery systems have emerged as promising approaches for enhancing the efficacy of wound healing treatments in diabetic patients. This review aims to provide an overview of the current a...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Harish Bhardwaj Sulekha Khute Ram Kumar Sahu Rajendra Kumar Jangde Source Type: research

Radical Scavenging, Anti-Inflammatory, and Hepatoprotective Activities of Pentacyclic Triterpene isolated from Rosa webbiana
CONCLUSION: The compound ARW1 exhibited anti-radical, anti-inflammatory and hepatoprotective effects. The anti-inflammatory and hepatoprotective activities may be attributed to anti-oxidant potential of the compound.PMID:37957908 | DOI:10.2174/0113894501261030231101184216 (Source: Current Drug Targets)
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Abdullah Khan Mir Azam Khan Achyut Adhikari Source Type: research

Syndecan-1: A Novel Diagnostic and Therapeutic Target in Liver Diseases
Curr Drug Targets. 2023 Nov 7. doi: 10.2174/0113894501250057231102061624. Online ahead of print.ABSTRACTSyndecan-1 (SDC-1), known as a coreceptor of various growth factors or an integrin binding partner, regulates various cell behaviours. Under certain pathological conditions, SDC-1 is shed from the cell surface and plays a protective or pathogenic role in various diseases. In the liver, SDC-1 is highly expressed in hepatocytes, where it is localized on the basolateral surface. It is critical to the cellular and molecular functions of hepatocytes, including their attachment to hepatitis viruses. Previous studies have repor...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Yingli He Xiaoli Zhang Yalei Zhao Liangru Liu Source Type: research

Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing
Curr Drug Targets. 2023 Nov 9. doi: 10.2174/0113894501260002231101080505. Online ahead of print.ABSTRACTThe diabetic wound is excessively vulnerable to infection because the diabetic wound suggests delayed and incomplete healing techniques. Presently, wounds and ulcers related to diabetes have additionally increased the medical burden. A diabetic wound can impair mobility, lead to amputations, or even death. In recent times, advanced drug delivery systems have emerged as promising approaches for enhancing the efficacy of wound healing treatments in diabetic patients. This review aims to provide an overview of the current a...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Harish Bhardwaj Sulekha Khute Ram Kumar Sahu Rajendra Kumar Jangde Source Type: research

Radical Scavenging, Anti-Inflammatory, and Hepatoprotective Activities of Pentacyclic Triterpene isolated from Rosa webbiana
CONCLUSION: The compound ARW1 exhibited anti-radical, anti-inflammatory and hepatoprotective effects. The anti-inflammatory and hepatoprotective activities may be attributed to anti-oxidant potential of the compound.PMID:37957908 | DOI:10.2174/0113894501261030231101184216 (Source: Current Drug Targets)
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Abdullah Khan Mir Azam Khan Achyut Adhikari Source Type: research

Targeted Delivery Strategies of Herbal-Based Nanogels: Advancements and Applications
The objective of this review is to thoroughly investigate herbal nano gels as a promising drug delivery approach for the management of various chronic and acute disorders. Herbal nano gels are a novel and promising drug delivery technique, offering special benefits for better therapeutic efficacy. This review offers a comprehensive analysis of the herbal nano gels with a particular emphasis on their evaluation concerning conventional dosage forms, polymer selection criteria, drug release mechanisms, and applications. The comparison study demonstrates that herbal nano gels have different benefits over conventional dose form...
Source: Current Drug Targets - November 13, 2023 Category: Drugs & Pharmacology Authors: Sudhanshu Mishra Sonali Jayronia Lalit Kumar Tyagi Kanchan Kohli Source Type: research

Targeted Delivery Strategies of Herbal-Based Nanogels: Advancements and Applications
The objective of this review is to thoroughly investigate herbal nano gels as a promising drug delivery approach for the management of various chronic and acute disorders. Herbal nano gels are a novel and promising drug delivery technique, offering special benefits for better therapeutic efficacy. This review offers a comprehensive analysis of the herbal nano gels with a particular emphasis on their evaluation concerning conventional dosage forms, polymer selection criteria, drug release mechanisms, and applications. The comparison study demonstrates that herbal nano gels have different benefits over conventional dose form...
Source: Current Drug Targets - November 13, 2023 Category: Drugs & Pharmacology Authors: Sudhanshu Mishra Sonali Jayronia Lalit Kumar Tyagi Kanchan Kohli Source Type: research

N-Heterocycle based Degraders (PROTACs) Manifesting Anticancer Efficacy: Recent Advances
Curr Drug Targets. 2023 Nov 8. doi: 10.2174/0113894501273969231102095615. Online ahead of print.ABSTRACTProteolysis Targeting Chimeras (PROTACs) technology has emerged as a promising strategy for the treatment of undruggable therapeutic targets. Researchers have invested a great effort in developing druggable PROTACs; however, the problems associated with PROTACs, including poor solubility, metabolic stability, cell permeability, and pharmacokinetic profile, restrict their clinical utility. Thus, there is a pressing need to expand the size of the armory of PROTACs which will escalate the chances of pinpointing new PROTACs ...
Source: Current Drug Targets - November 10, 2023 Category: Drugs & Pharmacology Authors: Suddhasatwa Banerjee Sachin Sharma Amandeep Thakur Ritika Sachdeva Ram Sharma Kunal Nepali Jing Ping Liou Source Type: research

NLRP3: A Promising Therapeutic Target for Inflammatory Bowel Disease
Curr Drug Targets. 2023 Nov 8. doi: 10.2174/0113894501255960231101105113. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is an intestinal disease with complicated pathological mechanisms. The incidence of IBD has been increasing in recent years, which has a significant negative impact on the lives of patients. Therefore, it is particularly important to find new therapeutic targets and innovative drugs for the development of IBD. Recent studies have revealed that NLRP3 inflammatory vesicles can play an important role in maintaining intestinal homeostasi...
Source: Current Drug Targets - November 10, 2023 Category: Drugs & Pharmacology Authors: Jiayu Zhang Shuyan Zeng Peng Wang Youxiang Chen Chunyan Zeng Source Type: research

Common Clinical Features of Cases with Mpox Reinfection
Curr Drug Targets. 2023 Nov 8. doi: 10.2174/0113894501267823231103103344. Online ahead of print.NO ABSTRACTPMID:37946355 | DOI:10.2174/0113894501267823231103103344 (Source: Current Drug Targets)
Source: Current Drug Targets - November 10, 2023 Category: Drugs & Pharmacology Authors: Masoud Keikha Mohammad Abavisani Amirhossein Sahebkar Source Type: research

N-Heterocycle based Degraders (PROTACs) Manifesting Anticancer Efficacy: Recent Advances
Curr Drug Targets. 2023 Nov 8. doi: 10.2174/0113894501273969231102095615. Online ahead of print.ABSTRACTProteolysis Targeting Chimeras (PROTACs) technology has emerged as a promising strategy for the treatment of undruggable therapeutic targets. Researchers have invested a great effort in developing druggable PROTACs; however, the problems associated with PROTACs, including poor solubility, metabolic stability, cell permeability, and pharmacokinetic profile, restrict their clinical utility. Thus, there is a pressing need to expand the size of the armory of PROTACs which will escalate the chances of pinpointing new PROTACs ...
Source: Current Drug Targets - November 10, 2023 Category: Drugs & Pharmacology Authors: Suddhasatwa Banerjee Sachin Sharma Amandeep Thakur Ritika Sachdeva Ram Sharma Kunal Nepali Jing Ping Liou Source Type: research

NLRP3: A Promising Therapeutic Target for Inflammatory Bowel Disease
Curr Drug Targets. 2023 Nov 8. doi: 10.2174/0113894501255960231101105113. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is an intestinal disease with complicated pathological mechanisms. The incidence of IBD has been increasing in recent years, which has a significant negative impact on the lives of patients. Therefore, it is particularly important to find new therapeutic targets and innovative drugs for the development of IBD. Recent studies have revealed that NLRP3 inflammatory vesicles can play an important role in maintaining intestinal homeostasi...
Source: Current Drug Targets - November 10, 2023 Category: Drugs & Pharmacology Authors: Jiayu Zhang Shuyan Zeng Peng Wang Youxiang Chen Chunyan Zeng Source Type: research

Common Clinical Features of Cases with Mpox Reinfection
Curr Drug Targets. 2023 Nov 8. doi: 10.2174/0113894501267823231103103344. Online ahead of print.NO ABSTRACTPMID:37946355 | DOI:10.2174/0113894501267823231103103344 (Source: Current Drug Targets)
Source: Current Drug Targets - November 10, 2023 Category: Drugs & Pharmacology Authors: Masoud Keikha Mohammad Abavisani Amirhossein Sahebkar Source Type: research

N-Heterocycle based Degraders (PROTACs) Manifesting Anticancer Efficacy: Recent Advances
Curr Drug Targets. 2023 Nov 8. doi: 10.2174/0113894501273969231102095615. Online ahead of print.ABSTRACTProteolysis Targeting Chimeras (PROTACs) technology has emerged as a promising strategy for the treatment of undruggable therapeutic targets. Researchers have invested a great effort in developing druggable PROTACs; however, the problems associated with PROTACs, including poor solubility, metabolic stability, cell permeability, and pharmacokinetic profile, restrict their clinical utility. Thus, there is a pressing need to expand the size of the armory of PROTACs which will escalate the chances of pinpointing new PROTACs ...
Source: Current Drug Targets - November 10, 2023 Category: Drugs & Pharmacology Authors: Suddhasatwa Banerjee Sachin Sharma Amandeep Thakur Ritika Sachdeva Ram Sharma Kunal Nepali Jing Ping Liou Source Type: research