Sodium-Glucose Cotransporter 2 Inhibitors and Pathological Myocardial Hypertrophy
Curr Drug Targets. 2023 Sep 7. doi: 10.2174/1389450124666230907115831. Online ahead of print.ABSTRACTSodium-glucose cotransporter 2 (SGLT2) inhibitors are a new type of oral hypoglycemic drugs that exert a hypoglycemic effect by blocking the reabsorption of glucose in the proximal renal tubules, thus promoting the excretion of glucose from urine. Their hypoglycemic effect is not dependent on insulin. Increasing data shows that SGLT2 inhibitors improve cardiovascular outcomes in patients with type 2 diabetes. Previous studies have demonstrated that SGLT2 inhibitors can reduce pathological myocardial hypertrophy with or with...
Source: Current Drug Targets - September 11, 2023 Category: Drugs & Pharmacology Authors: Zhicheng Gao Jiaqi Bao Yilan Hu Junjie Tu Lifang Ye Lihong Wang Source Type: research

Extracellular Vesicles from Stromal Vascular Fraction of Human Adipose Tissue in the Development of Non-antibiotic Therapy
CONCLUSION: Additionally, the underlying science that explains how the inflammatory process aids in the clearance of infections and the restoration of homeostasis after the host immune system successfully defends against foreign pathogens, as well as the fact that adipose-derived SVF is a noninvasive, cost-effective source of a variety of parent immune cells that produces a good yield of EVs with the same genetic make-up as their parent cells, make this concept worthwhile. This research may thereby increase survival rates and survival quality in cases of resistant infections. Vocabulary: Drug- and cell-free therapy = Nano ...
Source: Current Drug Targets - September 11, 2023 Category: Drugs & Pharmacology Authors: Vani Murthy Halahalli Srinivasa Mohana Kumar Prakash Patil Nikhil Shetty Veena Shetty Source Type: research

Sodium-Glucose Cotransporter 2 Inhibitors and Pathological Myocardial Hypertrophy
Curr Drug Targets. 2023 Sep 7. doi: 10.2174/1389450124666230907115831. Online ahead of print.ABSTRACTSodium-glucose cotransporter 2 (SGLT2) inhibitors are a new type of oral hypoglycemic drugs that exert a hypoglycemic effect by blocking the reabsorption of glucose in the proximal renal tubules, thus promoting the excretion of glucose from urine. Their hypoglycemic effect is not dependent on insulin. Increasing data shows that SGLT2 inhibitors improve cardiovascular outcomes in patients with type 2 diabetes. Previous studies have demonstrated that SGLT2 inhibitors can reduce pathological myocardial hypertrophy with or with...
Source: Current Drug Targets - September 11, 2023 Category: Drugs & Pharmacology Authors: Zhicheng Gao Jiaqi Bao Yilan Hu Junjie Tu Lifang Ye Lihong Wang Source Type: research

Extracellular Vesicles from Stromal Vascular Fraction of Human Adipose Tissue in the Development of Non-antibiotic Therapy
CONCLUSION: Additionally, the underlying science that explains how the inflammatory process aids in the clearance of infections and the restoration of homeostasis after the host immune system successfully defends against foreign pathogens, as well as the fact that adipose-derived SVF is a noninvasive, cost-effective source of a variety of parent immune cells that produces a good yield of EVs with the same genetic make-up as their parent cells, make this concept worthwhile. This research may thereby increase survival rates and survival quality in cases of resistant infections. Vocabulary: Drug- and cell-free therapy = Nano ...
Source: Current Drug Targets - September 11, 2023 Category: Drugs & Pharmacology Authors: Vani Murthy Halahalli Srinivasa Mohana Kumar Prakash Patil Nikhil Shetty Veena Shetty Source Type: research

Sodium-Glucose Cotransporter 2 Inhibitors and Pathological Myocardial Hypertrophy
Curr Drug Targets. 2023 Sep 7. doi: 10.2174/1389450124666230907115831. Online ahead of print.ABSTRACTSodium-glucose cotransporter 2 (SGLT2) inhibitors are a new type of oral hypoglycemic drugs that exert a hypoglycemic effect by blocking the reabsorption of glucose in the proximal renal tubules, thus promoting the excretion of glucose from urine. Their hypoglycemic effect is not dependent on insulin. Increasing data shows that SGLT2 inhibitors improve cardiovascular outcomes in patients with type 2 diabetes. Previous studies have demonstrated that SGLT2 inhibitors can reduce pathological myocardial hypertrophy with or with...
Source: Current Drug Targets - September 11, 2023 Category: Drugs & Pharmacology Authors: Zhicheng Gao Jiaqi Bao Yilan Hu Junjie Tu Lifang Ye Lihong Wang Source Type: research

Extracellular Vesicles from Stromal Vascular Fraction of Human Adipose Tissue in the Development of Non-antibiotic Therapy
CONCLUSION: Additionally, the underlying science that explains how the inflammatory process aids in the clearance of infections and the restoration of homeostasis after the host immune system successfully defends against foreign pathogens, as well as the fact that adipose-derived SVF is a noninvasive, cost-effective source of a variety of parent immune cells that produces a good yield of EVs with the same genetic make-up as their parent cells, make this concept worthwhile. This research may thereby increase survival rates and survival quality in cases of resistant infections. Vocabulary: Drug- and cell-free therapy = Nano ...
Source: Current Drug Targets - September 11, 2023 Category: Drugs & Pharmacology Authors: Vani Murthy Halahalli Srinivasa Mohana Kumar Prakash Patil Nikhil Shetty Veena Shetty Source Type: research

Inhibitors of stimulator of interferon genes from 2019 to July 2022: An overview of the structure and bioactivity
Curr Drug Targets. 2023 Aug 31. doi: 10.2174/1389450124666230831160820. Online ahead of print.ABSTRACTStimulator of interferon genes (STING) plays a vital role in the human innate immune system. Aberrant expression of STING has been proven to be associated with several diseases, such as STING-associated vasculopathy with onset in infancy, Aicardi-Goutieres syndrome, and systemic lupus erythematosus. Therefore, inhibition of the STING signaling pathway can also be expected to provide effective therapeutic strategies for treating specific inflammatory and autoimmune diseases. However, the development of STING inhibitors is s...
Source: Current Drug Targets - September 1, 2023 Category: Drugs & Pharmacology Authors: Feng Xu Xinjian Tian Qiangsheng Zhu Ziwen Feng Hui Li Wei Dai Yeling Zhou Qi-Dong You Xiaoli Xu Source Type: research

Inhibitors of stimulator of interferon genes from 2019 to July 2022: An overview of the structure and bioactivity
Curr Drug Targets. 2023 Aug 31. doi: 10.2174/1389450124666230831160820. Online ahead of print.ABSTRACTStimulator of interferon genes (STING) plays a vital role in the human innate immune system. Aberrant expression of STING has been proven to be associated with several diseases, such as STING-associated vasculopathy with onset in infancy, Aicardi-Goutieres syndrome, and systemic lupus erythematosus. Therefore, inhibition of the STING signaling pathway can also be expected to provide effective therapeutic strategies for treating specific inflammatory and autoimmune diseases. However, the development of STING inhibitors is s...
Source: Current Drug Targets - September 1, 2023 Category: Drugs & Pharmacology Authors: Feng Xu Xinjian Tian Qiangsheng Zhu Ziwen Feng Hui Li Wei Dai Yeling Zhou Qi-Dong You Xiaoli Xu Source Type: research

Inhibitors of stimulator of interferon genes from 2019 to July 2022: An overview of the structure and bioactivity
Curr Drug Targets. 2023 Aug 31. doi: 10.2174/1389450124666230831160820. Online ahead of print.ABSTRACTStimulator of interferon genes (STING) plays a vital role in the human innate immune system. Aberrant expression of STING has been proven to be associated with several diseases, such as STING-associated vasculopathy with onset in infancy, Aicardi-Goutieres syndrome, and systemic lupus erythematosus. Therefore, inhibition of the STING signaling pathway can also be expected to provide effective therapeutic strategies for treating specific inflammatory and autoimmune diseases. However, the development of STING inhibitors is s...
Source: Current Drug Targets - September 1, 2023 Category: Drugs & Pharmacology Authors: Feng Xu Xinjian Tian Qiangsheng Zhu Ziwen Feng Hui Li Wei Dai Yeling Zhou Qi-Dong You Xiaoli Xu Source Type: research

Inhibitors of stimulator of interferon genes from 2019 to July 2022: An overview of the structure and bioactivity
Curr Drug Targets. 2023 Aug 31. doi: 10.2174/1389450124666230831160820. Online ahead of print.ABSTRACTStimulator of interferon genes (STING) plays a vital role in the human innate immune system. Aberrant expression of STING has been proven to be associated with several diseases, such as STING-associated vasculopathy with onset in infancy, Aicardi-Goutieres syndrome, and systemic lupus erythematosus. Therefore, inhibition of the STING signaling pathway can also be expected to provide effective therapeutic strategies for treating specific inflammatory and autoimmune diseases. However, the development of STING inhibitors is s...
Source: Current Drug Targets - September 1, 2023 Category: Drugs & Pharmacology Authors: Feng Xu Xinjian Tian Qiangsheng Zhu Ziwen Feng Hui Li Wei Dai Yeling Zhou Qi-Dong You Xiaoli Xu Source Type: research

Inhibitors of stimulator of interferon genes from 2019 to July 2022: An overview of the structure and bioactivity
Curr Drug Targets. 2023 Aug 31. doi: 10.2174/1389450124666230831160820. Online ahead of print.ABSTRACTStimulator of interferon genes (STING) plays a vital role in the human innate immune system. Aberrant expression of STING has been proven to be associated with several diseases, such as STING-associated vasculopathy with onset in infancy, Aicardi-Goutieres syndrome, and systemic lupus erythematosus. Therefore, inhibition of the STING signaling pathway can also be expected to provide effective therapeutic strategies for treating specific inflammatory and autoimmune diseases. However, the development of STING inhibitors is s...
Source: Current Drug Targets - September 1, 2023 Category: Drugs & Pharmacology Authors: Feng Xu Xinjian Tian Qiangsheng Zhu Ziwen Feng Hui Li Wei Dai Yeling Zhou Qi-Dong You Xiaoli Xu Source Type: research

Inhibitors of stimulator of interferon genes from 2019 to July 2022: An overview of the structure and bioactivity
Curr Drug Targets. 2023 Aug 31. doi: 10.2174/1389450124666230831160820. Online ahead of print.ABSTRACTStimulator of interferon genes (STING) plays a vital role in the human innate immune system. Aberrant expression of STING has been proven to be associated with several diseases, such as STING-associated vasculopathy with onset in infancy, Aicardi-Goutieres syndrome, and systemic lupus erythematosus. Therefore, inhibition of the STING signaling pathway can also be expected to provide effective therapeutic strategies for treating specific inflammatory and autoimmune diseases. However, the development of STING inhibitors is s...
Source: Current Drug Targets - September 1, 2023 Category: Drugs & Pharmacology Authors: Feng Xu Xinjian Tian Qiangsheng Zhu Ziwen Feng Hui Li Wei Dai Yeling Zhou Qi-Dong You Xiaoli Xu Source Type: research

Inhibitors of stimulator of interferon genes from 2019 to July 2022: An overview of the structure and bioactivity
Curr Drug Targets. 2023 Aug 31. doi: 10.2174/1389450124666230831160820. Online ahead of print.ABSTRACTStimulator of interferon genes (STING) plays a vital role in the human innate immune system. Aberrant expression of STING has been proven to be associated with several diseases, such as STING-associated vasculopathy with onset in infancy, Aicardi-Goutieres syndrome, and systemic lupus erythematosus. Therefore, inhibition of the STING signaling pathway can also be expected to provide effective therapeutic strategies for treating specific inflammatory and autoimmune diseases. However, the development of STING inhibitors is s...
Source: Current Drug Targets - September 1, 2023 Category: Drugs & Pharmacology Authors: Feng Xu Xinjian Tian Qiangsheng Zhu Ziwen Feng Hui Li Wei Dai Yeling Zhou Qi-Dong You Xiaoli Xu Source Type: research

Inhibitors of stimulator of interferon genes from 2019 to July 2022: An overview of the structure and bioactivity
Curr Drug Targets. 2023 Aug 31. doi: 10.2174/1389450124666230831160820. Online ahead of print.ABSTRACTStimulator of interferon genes (STING) plays a vital role in the human innate immune system. Aberrant expression of STING has been proven to be associated with several diseases, such as STING-associated vasculopathy with onset in infancy, Aicardi-Goutieres syndrome, and systemic lupus erythematosus. Therefore, inhibition of the STING signaling pathway can also be expected to provide effective therapeutic strategies for treating specific inflammatory and autoimmune diseases. However, the development of STING inhibitors is s...
Source: Current Drug Targets - September 1, 2023 Category: Drugs & Pharmacology Authors: Feng Xu Xinjian Tian Qiangsheng Zhu Ziwen Feng Hui Li Wei Dai Yeling Zhou Qi-Dong You Xiaoli Xu Source Type: research

Histone Deacetylase (HDAC) Inhibitors: A Fruitful Lead for Medicinal Chemists in the Discovery of Novel Drug(s) for Various Health Disorders
Curr Drug Targets. 2023;24(9):697. doi: 10.2174/138945012409230720102737.NO ABSTRACTPMID:37638611 | DOI:10.2174/138945012409230720102737 (Source: Current Drug Targets)
Source: Current Drug Targets - August 28, 2023 Category: Drugs & Pharmacology Authors: Dilipkumar Pal Source Type: research