A perspective on EGFR and Proteasome based targeted therapy for cancer
CONCLUSION: There are numerous strategies that are discussed in these patents to improve the pharmacokinetics and pharmacodynamics of EGFR and proteosome inhibitors. Further, resistance of targeted therapy after long term treatment can be overcome by using various excipients that can be used as a strategy to carry drug in order to overcome resistance. However, there is a need and scope for improving targeted therapeutics for cancer treatment with better fundamentals and characteristics. The widespread research over cancer therapy can create the path for future advancements in therapy with more prominent outcomes.PMID:36089...
Source: Current Drug Targets - September 12, 2022 Category: Drugs & Pharmacology Authors: Drishti Panjawani Deepak Mishra Shruti Patel Viral Patel Abhay Dharamsi Asha Patel Source Type: research

A perspective on EGFR and Proteasome based targeted therapy for cancer
CONCLUSION: There are numerous strategies that are discussed in these patents to improve the pharmacokinetics and pharmacodynamics of EGFR and proteosome inhibitors. Further, resistance of targeted therapy after long term treatment can be overcome by using various excipients that can be used as a strategy to carry drug in order to overcome resistance. However, there is a need and scope for improving targeted therapeutics for cancer treatment with better fundamentals and characteristics. The widespread research over cancer therapy can create the path for future advancements in therapy with more prominent outcomes.PMID:36089...
Source: Current Drug Targets - September 12, 2022 Category: Drugs & Pharmacology Authors: Drishti Panjawani Deepak Mishra Shruti Patel Viral Patel Abhay Dharamsi Asha Patel Source Type: research

Lung pneumonitis and fibrosis in cancer therapy; A review on cellular and molecular mechanisms
Curr Drug Targets. 2022 Sep 7. doi: 10.2174/1389450123666220907144131. Online ahead of print.ABSTRACTFibrosis and pneumonitis are the most important side effects of lung tissue following cancer therapy. Radiotherapy and chemotherapy by some drugs such as bleomycin can induce pneumonitis and fibrosis. Targeted therapy and immunotherapy also may induce pneumonitis and fibrosis with a lesser extent compared to chemotherapy and radiotherapy. Activation of lymphocytes by immunotherapy or infiltration of inflammatory cells such as macrophages, lymphocytes, neutrophils, and mast cells following chemo/radiation therapy can induce ...
Source: Current Drug Targets - September 9, 2022 Category: Drugs & Pharmacology Authors: Chaofeng Xu Zhongtu Shang Masoud Najafi Source Type: research

Digoxin and Outcomes in Patients with Heart Failure and Preserved Ejection Fraction [HFpEF] Patients: A Systematic Review and Meta-analysis
CONCLUSION: The results of this meta-analysis suggest that digoxin does not have any significant effect on long-term outcomes of HFpEF patients, including "all-cause mortality", "all-cause hospitalization", "hospitalization because of HF" and "all-cause mortality or hospitalization of HF".PMID:36065922 | DOI:10.2174/1389450123666220906093058 (Source: Current Drug Targets)
Source: Current Drug Targets - September 6, 2022 Category: Drugs & Pharmacology Authors: Seyed H Hashemi-Shahri Ali Aghajanloo Vahid Ghavami Omid Arasteh Amir Hooshang Mohammadpour Željko Reiner Amirhossein Sahebkar Source Type: research

A Comprehensive Review on Liver Targeting: Emphasis on Nanotechnology-Based Molecular Targets and Receptors Mediated Approaches
CONCLUSION: Receptors based targeting approach is one such approach that was explored by researchers to develop novel formulations which can ensure site specific drug delivery. Several receptors are present on the surfaces of liver cells which are reported to be highly overexpressed in the various disease conditions. Its all are helpful for the treatment of the liver cancer.PMID:36065923 | DOI:10.2174/1389450123666220906091432 (Source: Current Drug Targets)
Source: Current Drug Targets - September 6, 2022 Category: Drugs & Pharmacology Authors: Ashwini Kumar Mishra Mukesh Pandey Hitesh Kumar Dewangan Neha Sl Pravat Kumar Sahoo Source Type: research

Digoxin and Outcomes in Patients with Heart Failure and Preserved Ejection Fraction [HFpEF] Patients: A Systematic Review and Meta-analysis
CONCLUSION: The results of this meta-analysis suggest that digoxin does not have any significant effect on long-term outcomes of HFpEF patients, including "all-cause mortality", "all-cause hospitalization", "hospitalization because of HF" and "all-cause mortality or hospitalization of HF".PMID:36065922 | DOI:10.2174/1389450123666220906093058 (Source: Current Drug Targets)
Source: Current Drug Targets - September 6, 2022 Category: Drugs & Pharmacology Authors: Seyed H Hashemi-Shahri Ali Aghajanloo Vahid Ghavami Omid Arasteh Amir Hooshang Mohammadpour Željko Reiner Amirhossein Sahebkar Source Type: research

A Comprehensive Review on Liver Targeting: Emphasis on Nanotechnology-Based Molecular Targets and Receptors Mediated Approaches
CONCLUSION: Receptors based targeting approach is one such approach that was explored by researchers to develop novel formulations which can ensure site specific drug delivery. Several receptors are present on the surfaces of liver cells which are reported to be highly overexpressed in the various disease conditions. Its all are helpful for the treatment of the liver cancer.PMID:36065923 | DOI:10.2174/1389450123666220906091432 (Source: Current Drug Targets)
Source: Current Drug Targets - September 6, 2022 Category: Drugs & Pharmacology Authors: Ashwini Kumar Mishra Mukesh Pandey Hitesh Kumar Dewangan Neha Sl Pravat Kumar Sahoo Source Type: research

Targeting AMPK Signaling in the Liver: Implications for Obesity and Type 2 Diabetes Mellitus
Curr Drug Targets. 2022;23(11):1057-1071. doi: 10.2174/1389450123666220429082702.ABSTRACTObesity and type 2 diabetes mellitus (T2DM), as common metabolic diseases, are pathologically characterized by overnutrition and insulin resistance (IR), which subsequently lead to glucose and lipid metabolism disorders. The liver, a major metabolic organ of the body, integrates hormone and metabolic signals to regulate the synthesis of lipids and glucose as well as their transport to peripheral tissues, hence playing an essential role in the development of obesity and T2DM. Adenosine 5'-monophosphate-activated protein kinase (AMPK) is...
Source: Current Drug Targets - August 27, 2022 Category: Drugs & Pharmacology Authors: Doudou Wang Lin Yang Ying Liu Source Type: research

Combinational Approaches Targeting Various Aspects Involved in Intestinal Barrier Dysfunction-Induced Anxiety
Curr Drug Targets. 2022;23(11):1085-1098. doi: 10.2174/1389450123666220428093419.ABSTRACTAnxiety disorder is one of the most prevalent psychiatric disorders. The high prevalence of comorbid gastrointestinal disorders and anxiety, as well as various limitations in current therapy, have necessitated the search for alternative techniques. The Gut-Brain Axis is the connecting link between the gut and the brain. One of the reasons for the Gut-Brain Axis malfunction resulting in HPA axis stimulation and anxiety is intestinal barrier dysfunction. Gut microorganisms, lipopolysaccharides, and other factors can stimulate the disrupt...
Source: Current Drug Targets - August 27, 2022 Category: Drugs & Pharmacology Authors: Anita Murugan Pallar Pravin Popatrao Kale Source Type: research

Corrigendum to: GSK-3 Inhibitors in the Regulation and Control of Colon Carcinoma
Curr Drug Targets. 2022;23(11):1126. doi: 10.2174/138945012311220720160340.ABSTRACTThe author requested to add a co-author after the publication of the original article [1]. In this correction, the author has been added in the article entitled "GSK-3 Inhibitors in the Regulation and Control of Colon Carcinoma" in the journal "Current Drug Targets" 2021; 22(13), 1485-1495. Details of the error and a correction are provided here. The original editorial can be found online at 10.2174/1389450122666210204203950 We regret any errors and apologize to the readers. Original: Sitansu S. Nanda1, Md Imran Hossain1, Heongkyu Ju2 and Do...
Source: Current Drug Targets - August 27, 2022 Category: Drugs & Pharmacology Authors: Sitansu S Nanda Md Imran Hossain Heongkyu Ju Georgia C Papaefthymiou Dong Kee Yi Source Type: research

Elabela peptide: an emerging target in therapeutics
Curr Drug Targets. 2022 Aug 26. doi: 10.2174/1389450123666220826160123. Online ahead of print.ABSTRACTElabela, a bioactive micropeptide, is recognized as the second endogenous ligand for Apelin receptor and is widely distributed in different tissues and organs. Elabela plays important role in various physiological processes such blood pressure control, heart morphogenesis, apoptosis, angiogenesis, cell proliferation, migration, etc. Elabela is also implicated in pathological conditions like cardiac dysfunctions, heart failure, hypertension, kidney diseases, cancer and CNS disorders. The association of Elabela with these di...
Source: Current Drug Targets - August 27, 2022 Category: Drugs & Pharmacology Authors: Maneesha Sharma Kedar S Prabhavalkar Lokesh Kumar Bhatt Source Type: research

Fibrinogen, Fibrin, and Fibrin Degradation Products in COVID-19
Curr Drug Targets. 2022 Aug 26. doi: 10.2174/1389450123666220826162900. Online ahead of print.ABSTRACTSevere Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the highly pathogenic and highly transmissible human coronavirus that is the causative agent for the worldwide COVID-19 pandemic. COVID-19 manifests predominantly as a respiratory illness with symptoms consistent with a viral pneumonia, but other organ systems (e.g., kidney, heart, brain) can also become perturbed in COVID-19 patients. Accumulating data suggest that significant activation of the hemostatic system is a common pathological manifestation of SARS-...
Source: Current Drug Targets - August 27, 2022 Category: Drugs & Pharmacology Authors: Kadri Kangro Alisa S Wolberg Matthew J Flick Source Type: research

Targeting AMPK Signaling in the Liver: Implications for Obesity and Type 2 Diabetes Mellitus
Curr Drug Targets. 2022;23(11):1057-1071. doi: 10.2174/1389450123666220429082702.ABSTRACTObesity and type 2 diabetes mellitus (T2DM), as common metabolic diseases, are pathologically characterized by overnutrition and insulin resistance (IR), which subsequently lead to glucose and lipid metabolism disorders. The liver, a major metabolic organ of the body, integrates hormone and metabolic signals to regulate the synthesis of lipids and glucose as well as their transport to peripheral tissues, hence playing an essential role in the development of obesity and T2DM. Adenosine 5'-monophosphate-activated protein kinase (AMPK) is...
Source: Current Drug Targets - August 27, 2022 Category: Drugs & Pharmacology Authors: Doudou Wang Lin Yang Ying Liu Source Type: research

Combinational Approaches Targeting Various Aspects Involved in Intestinal Barrier Dysfunction-Induced Anxiety
Curr Drug Targets. 2022;23(11):1085-1098. doi: 10.2174/1389450123666220428093419.ABSTRACTAnxiety disorder is one of the most prevalent psychiatric disorders. The high prevalence of comorbid gastrointestinal disorders and anxiety, as well as various limitations in current therapy, have necessitated the search for alternative techniques. The Gut-Brain Axis is the connecting link between the gut and the brain. One of the reasons for the Gut-Brain Axis malfunction resulting in HPA axis stimulation and anxiety is intestinal barrier dysfunction. Gut microorganisms, lipopolysaccharides, and other factors can stimulate the disrupt...
Source: Current Drug Targets - August 27, 2022 Category: Drugs & Pharmacology Authors: Anita Murugan Pallar Pravin Popatrao Kale Source Type: research

Corrigendum to: GSK-3 Inhibitors in the Regulation and Control of Colon Carcinoma
Curr Drug Targets. 2022;23(11):1126. doi: 10.2174/138945012311220720160340.ABSTRACTThe author requested to add a co-author after the publication of the original article [1]. In this correction, the author has been added in the article entitled "GSK-3 Inhibitors in the Regulation and Control of Colon Carcinoma" in the journal "Current Drug Targets" 2021; 22(13), 1485-1495. Details of the error and a correction are provided here. The original editorial can be found online at 10.2174/1389450122666210204203950 We regret any errors and apologize to the readers. Original: Sitansu S. Nanda1, Md Imran Hossain1, Heongkyu Ju2 and Do...
Source: Current Drug Targets - August 27, 2022 Category: Drugs & Pharmacology Authors: Sitansu S Nanda Md Imran Hossain Heongkyu Ju Georgia C Papaefthymiou Dong Kee Yi Source Type: research