Complexation of Bioelements and Toxic Metals by Polyphenolic Compounds - Implications for Health.
Abstract Nowadays growing interest in the possibility of prophylactic and therapeutic use of plant products rich in biologically active compounds has been observed. Among them special interest has been focused on polyphenol-rich products. Owing to multidirectional favourable action of polyphenols, products rich in these compounds are recommended as functional food in the case of civilization diseases. Moreover, data from studies in animal models show that polyphenols may be a promising preventive/therapeutic strategy for xenobiotics, including toxic heavy metals. The protective impact of polyphenols against metals...
Source: Current Drug Targets - April 2, 2018 Category: Drugs & Pharmacology Authors: Borowska S, Brzoska MM, Tomczyk M Tags: Curr Drug Targets Source Type: research

Editorial: Bone Drug Targets.
PMID: 29589822 [PubMed - in process] (Source: Current Drug Targets)
Source: Current Drug Targets - March 29, 2018 Category: Drugs & Pharmacology Authors: Dass CR Tags: Curr Drug Targets Source Type: research

New Sides of Aldosterone Action in Cardiovascular System as Potential Targets for Therapeutic Intervention.
Abstract Aldosterone, the main mineralocorticoid hormone, plays a crucial role in the regulation of electrolyte homeostasis and blood pressure. Although, this role is undoubtedly important, it is not a hormonal action that attracts the most attention. Aldosterone seems to be very important important as a local messenger in the pathology of cardiovascular diseases (CVD). In the last few years, the attention was focused on the correlation between raised aldosterone level and increased risk of cardiovascular events. It has been demonstrated that aldosterone contributes to fibrosis, inflammation, endothelial dysfuncti...
Source: Current Drug Targets - March 26, 2018 Category: Drugs & Pharmacology Authors: Kolodziejczyk P, Gromotowicz-Poplawska A, Aleksiejczuk M, Chabielska E, Tutka P, Miltyk W Tags: Curr Drug Targets Source Type: research

Flavonoids and its neuroprotective effects on brain ischemia and neurodegenerative diseases.
Abstract Brain ischemia is among the leading cause of death with majority of the cases are associated with ischemic strokes. It can occur in two form of either focal or global ischemia. Neurodegenerative disorder such as Alzheimer and Parkinson diseases is also on the rise worldwide. These disorders have common similarities; i.e. they all affecting the central nervous system with debilitating effect to the patient. In this review, we look into the promising role of flavonoids, a natural bioactive compound found abundant in vegetables, fruits and traditional herbs. Treatment with flavonoids such as curcumin, lycope...
Source: Current Drug Targets - March 26, 2018 Category: Drugs & Pharmacology Authors: Putteeraj M, Lim WL, Teoh SL, Yahaya MF Tags: Curr Drug Targets Source Type: research

Nanoparticles in Cancer Treatment: Opportunities and Obstacles.
This article highlights the various ways nanotechnology is being used to improve the treatment and management of cancer. We also discuss the opportunities and obstacles in this area and provide an up to date review of progress in the treatment of cancer. PMID: 29577855 [PubMed - as supplied by publisher] (Source: Current Drug Targets)
Source: Current Drug Targets - March 26, 2018 Category: Drugs & Pharmacology Authors: Awasthi R, Roseblade A, Hansbro PM, Rathbone MJ, Dua K, Bebawy M Tags: Curr Drug Targets Source Type: research

Early urinary markers for diabetic and other kidney diseases.
CONCLUSION: Although significant advances have been made in medical therapy, the degree of morbidity and mortality associated with kidney diseases remain despondently high. Besides the serum markers, urinary markers may provide a better prediction of progression of the damage to the kidneys in diabetic patients. PMID: 29552988 [PubMed - as supplied by publisher] (Source: Current Drug Targets)
Source: Current Drug Targets - March 19, 2018 Category: Drugs & Pharmacology Authors: Thakur V, Chattopadhyay M Tags: Curr Drug Targets Source Type: research

Recent Progress in Clinical Development of Therapeutic Antibodies Targeting Glycan-Binding Proteins.
CONCLUSION: There are several therapeutic antibodies being developed targeting glycan-binding proteins, including CD22, CD33, DEC-205, and CD62P, for different diseases. The clinical investigations demonstrated benefits of treatments with one antibody-drug conjugate against CD22 being approved by the regulatory agencies. The recent progresses in clinical developments of these antibodies have provided great promises in therapeutic targeting of more glycan-binding proteins for treating multiple diseases, including inflammation, autoimmune diseases, and hematological malignancies. PMID: 29521224 [PubMed - as supplied by ...
Source: Current Drug Targets - March 8, 2018 Category: Drugs & Pharmacology Authors: Zhou Q Tags: Curr Drug Targets Source Type: research

Role of Haematopoietic Stem Cell Transplantation in management of Severe Chronic Neutropenia.
Abstract The inherited form of Severe Chronic Neutropenia called Severe Congenital Neutropenia (SCN) is an intrinsic defect of neutrophils maturation. SCN affected patients are at risk to develop lethal in-fections and to transform into myelodisplasia (MDS) and/or acute laeukemia(AL). Use of Granulocyte-Colony-Stimulating Factor (G-CSF) has significantly improved the prognosis of affected patients, but the only definitive cure for the disease is Haematopoietic Stem Cell Trans-plantation (HSCT). Overall Survival of SCN patients has been assessed at around 85% after 3 years from transplantation . The morbility and m...
Source: Current Drug Targets - March 8, 2018 Category: Drugs & Pharmacology Authors: Fioredda F Tags: Curr Drug Targets Source Type: research

A New Investigational Perspective for Purines Against Glioblastoma Invasiveness.
CONCLUSIONS: Considering the significance of EMT in GBM aggressiveness and the promising involvement of purines in this process, we think that further research in this regard may open the way towards a new therapeutic approach for the control of GBM invasiveness/recurrence. PMID: 29484991 [PubMed - as supplied by publisher] (Source: Current Drug Targets)
Source: Current Drug Targets - February 26, 2018 Category: Drugs & Pharmacology Authors: Giuliani P, Zuccarini M, Carluccio M, Ziberi S, Di Iorio P, Caciagli F, Ciccarelli R Tags: Curr Drug Targets Source Type: research

Potential of liquid biopsy in Papillary Thyroid Carcinoma in context of miRNA, BRAF and p53 mutation.
CONCLUSION: Numerous of molecular variation characterize recent diagnostic and prognostic markers and therapeutic targets for this type of cancer, which offer unique chances for further research and clinical development of innovative treatment strategies for thyroid cancer. PMID: 29484992 [PubMed - as supplied by publisher] (Source: Current Drug Targets)
Source: Current Drug Targets - February 26, 2018 Category: Drugs & Pharmacology Authors: Perdas E, Stawski R, Nowak D, Zubrzycka M Tags: Curr Drug Targets Source Type: research

The Use of Antidepressants for Physical and Psychological Symptoms in Cancer.
Abstract : Cancer patients are commonly associated with various physical and psychological symptoms. In view of this matter, palliative care is usually given to relieve those symptoms, improve quality of life, and increase medication adherence. Antidepressants are generally accepted for the treatment of depression among patients with or without cancer. Some other potential benefits of these medications have been experienced in clinical practice. Therefore, this study aimed to review the use of antidepressant for physical and psychological symptoms in cancer. Our findings showed mixed result of positive and negativ...
Source: Current Drug Targets - February 26, 2018 Category: Drugs & Pharmacology Authors: Zaini S, Guan NGC, Sulaiman AH, Zainal NZ, Huri HZ, Shamsudin SH Tags: Curr Drug Targets Source Type: research

NF- κB-IKKβ pathway as a target for drug development: realities, challenges and perspectives.
CONCLUSIONS: Although only proteasome inhibitors, such as bortezomib and carfilzomib, are a reality as therapeutically useful drugs among the known modulators of possible targets in the NF-κB-IKKβ pathway, some other prototypes described as IKKβ inhibitors have entered clinical stages as drug candidates for the control of inflammatory diseases. It is important to note that some classical drugs available on the pharmaceutical market, such as acetylsalicylic acid, were also described more recently as NF-κB pathway modulators as IKKβ inhibitors. PMID: 29468963 [PubMed - as supplied by publisher...
Source: Current Drug Targets - February 19, 2018 Category: Drugs & Pharmacology Authors: Freitas RHCN, Fraga CAM Tags: Curr Drug Targets Source Type: research

Recent advances in antibacterial, antiprotozoal and antifungal trends of Eurycoma longifolia: A review of therapeutic implications and future prospects.
CONCLUSION: Based on the critical analysis of the literature, we identified that E. longifolia exhibits promising antibacterial, antiprotozoal, and antifungal efficacies against various pathogenic microbes and thus can be considered as a potential complementary and alternative antimicrobial therapy. PMID: 29468964 [PubMed - as supplied by publisher] (Source: Current Drug Targets)
Source: Current Drug Targets - February 19, 2018 Category: Drugs & Pharmacology Authors: Thu HE, Hussain Z, Mohamed IN, Shuid AN Tags: Curr Drug Targets Source Type: research

Versatility of Cancer Associated Fibroblasts: Commendable Targets For Anti-Tumor Therapy.
CONCLUSION: The potential role of CAF in anti-tumor therapy is based on its coherent response against drugs, targeting different tumor sections through these genetically more stable and anti-immuno-supportive CAF cells. CAF can be targeted through immunity system; growth factors (GF) including Transforming growth factor (TGF), vascular endothelial GF, fibroblast GF, platelet derived GF; and TME elements including hypoxia, carbonic anhydrase, extracellular matrix (ECM). Collectively these features of CAF make it most vulnerable against single as well as combinational, anti-tumor therapy for synergistic or additive effects. ...
Source: Current Drug Targets - February 19, 2018 Category: Drugs & Pharmacology Authors: Khan GJ, Sun L, Khan S, Yuan S, Nongyue H Tags: Curr Drug Targets Source Type: research

S-Nitrosylation in regulation of inflammation and cell damage.
CONCLUSION: While keeping the background in mind, we address here the biological function of NO derivatives in medicine. We target four known compounds: SNAP, SIN- 1 chloride, SNP and GSNO to understand the effect of NO in different tissues. The objective is to analyze the existing findings to assess therapeutic relevance of NO-signaling during inflammation, vasodilation and tolerance. PMID: 29437005 [PubMed - as supplied by publisher] (Source: Current Drug Targets)
Source: Current Drug Targets - February 12, 2018 Category: Drugs & Pharmacology Authors: Dasgupta S, Gomez JJ, Singh I, Khan M Tags: Curr Drug Targets Source Type: research

Enteral administration of TKIs: report of a response to ceritinib in an ALK-positive NSCLC patient and literature review.
Abstract INTRODUCTION: Several reports attest the feasibility and the favorable outcomes of kinase inhibitors administration through feeding tubes or percutaneous endoscopic gastrostomies (PEG), mainly in non-small cell lung cancer (NSCLC) patients exposed to first-generation compounds. Here we present the case of an ALK-positive NSCLC patient who achieved cerebral and extra-cranial disease response with ceritinib (a novel ALK inhibitor) administered through a nasogastric tube (NGT). We moreover provide a review gathering clinical successes obtained with targeted agents intake through NGT or PEG. CASE PRESENT...
Source: Current Drug Targets - February 12, 2018 Category: Drugs & Pharmacology Authors: Facchinetti F, Bordi P, Bini P, Bidin L, Camisa R, Tiseo M Tags: Curr Drug Targets Source Type: research

Blood eosinophils as biomarkers to drive treatment choices in asthma and COPD.
Abstract Both asthma and COPD are complex, heterogeneous conditions comprising a wide range of phenotypes, some of which are refractory to currently available treatments. Elucidation of these phenotypes and identification of biomarkers with which to recognize them and guide appropriate treatment remains a priority. This review describes the utility of blood eosinophils as a surrogate biomarker of eosinophilic airway inflammation, a common feature of specific asthma and COPD phenotypes. The role of blood eosinophils in airway disease is described, as is their relevance in reflecting airway eosinophilia. Each diseas...
Source: Current Drug Targets - February 12, 2018 Category: Drugs & Pharmacology Authors: Patalano F, Kostikas K, Brindicci C Tags: Curr Drug Targets Source Type: research

Nanotechnology inspired advanced engineering fundamentals for optimizing drug delivery.
CONCLUSION: Nanomedicines may enhance the efficacy of therapeutic molecules and reduce their toxic effects. Meanwhile, further research works are required to rightly optimize (and define) the effectiveness, nanotoxicity, in vivo destiny and feasibility of these nanomedicines which, from a preclinical standpoint, are actually promising. PMID: 29412103 [PubMed - as supplied by publisher] (Source: Current Drug Targets)
Source: Current Drug Targets - February 6, 2018 Category: Drugs & Pharmacology Authors: Kassem AA Tags: Curr Drug Targets Source Type: research

Radiation-Induced Pulmonary Epithelial-Mesenchymal Transition: A Review of Targeting Molecular pathways and Mediators.
Abstract Radiotherapy is the most widely used treatment method for average and advanced lung cancer patients. Moreover, the clinical toxicities caused by radiotherapy are categorized into acute radiation pneumonitis and late pulmonary fibrosis. Epithelial-mesenchymal transition (EMT) is a complex physiological process involves many signaling molecules and proteins like adaptor proteins, and transcriptional factors. It was identified as a significant mechanism for fibrosis, wound healing and also cancer. A variety of biomarkers have appeared in radiation-induced lung EMT, some of which are acquired (N-cadherin, vim...
Source: Current Drug Targets - February 6, 2018 Category: Drugs & Pharmacology Authors: Sunilgowda SN, Nagarajan D, Nagarajan D Tags: Curr Drug Targets Source Type: research

Tocotrienols Regulate Bone Loss through Suppression on Osteoclast Differentiation and Activity: A Systematic Review.
Abstract There are accumulating studies reporting vitamin E in general exhibits bone protective effects. This systematic review, however discusses the effects of a group of vitamin E isomers, tocotrienols in preventing bone loss through osteoclast differentiation and activity suppression. This review is aimed to discuss the literature reporting the effects of tocotrienols on osteoclasts, the cells specialized for resorbing bone. Literature search for relevant studies was conducted using SCOPUS and PUBMED MEDLINE. The inclusion criteria were original research articles published that reported the effect of any tocot...
Source: Current Drug Targets - February 6, 2018 Category: Drugs & Pharmacology Authors: Radzi NFM, Ismail NAS, Alias E Tags: Curr Drug Targets Source Type: research

Nanocarrier Based Advances In Drug Delivery To Tumor: An Overview.
CONCLUSION: This review summarizes the advances in nanocarriers in terms of their methods of preparation and potential applications especially in tumors. PMID: 29384060 [PubMed - as supplied by publisher] (Source: Current Drug Targets)
Source: Current Drug Targets - January 30, 2018 Category: Drugs & Pharmacology Authors: Jain A, Kumari R, Tiwari A, Verma A, Tripathi A, Shrivastava A, Jain SK Tags: Curr Drug Targets Source Type: research

PPAR γ-targeting potential for radioprotection.
PPARγ-targeting potential for radioprotection. Curr Drug Targets. 2018 Jan 30;: Authors: Kaur S, Nag A, Singh AK, Sharma K Abstract Peroxisomal proliferator receptor gamma (PPARγ) is a class of nuclear hormone receptor family involved in insulin sensitization. In addition, PPARγ has a key role in the protection against oxidative stress and inflammation through regulation of NFkappaB levels and cross-talk with the Nrf-2 pathway. Also, its role in the modulation of immune response is substantial. Radiation-induced oxidative stress is the sole determinant of damage to hematopoietic, gas...
Source: Current Drug Targets - January 30, 2018 Category: Drugs & Pharmacology Authors: Kaur S, Nag A, Singh AK, Sharma K Tags: Curr Drug Targets Source Type: research

A review of the clinical, radiological and biochemical characteristics and genetic causes of high bone mass disorders.
CONCLUSION: The clarification of the etiologies of HBM may have a breakthrough role in understanding the molecular mechanisms involved in bone metabolism and may provide new pathways for the intervention of osteoporosis. PMID: 29359663 [PubMed - as supplied by publisher] (Source: Current Drug Targets)
Source: Current Drug Targets - January 22, 2018 Category: Drugs & Pharmacology Authors: Chen X, Yu H, Yu X Tags: Curr Drug Targets Source Type: research

Hypoperfusion of the aortic wall secondary to degeneration of adventitial vasa vasorum causes abdominal aortic aneurysms.
CONCLUSION: Thus, hypoperfusion of the aortic wall appeared to be sufficient to cause inflammation-induced AAA. These findings may provide potential targets for novel therapeutics for the management of an AAA. PMID: 29359664 [PubMed - as supplied by publisher] (Source: Current Drug Targets)
Source: Current Drug Targets - January 22, 2018 Category: Drugs & Pharmacology Authors: Tanaka H, Unno N, Suzuki Y, Sano H, Yata T, Urano T Tags: Curr Drug Targets Source Type: research

Pathogenic and therapeutic significance of angiotensin II type I receptor in abdominal aortic aneurysms.
CONCLUSIONS: Ang II/AT1 pathway plays a critical role in aneurysmal pathogenesis. Targeting AT1 via ARB will help establishing novel pharmacological therapies for limiting continuous enlargement of small AAAs in patients. PMID: 29359665 [PubMed - as supplied by publisher] (Source: Current Drug Targets)
Source: Current Drug Targets - January 22, 2018 Category: Drugs & Pharmacology Authors: Xu B, Xuan H, Iida Y, Miyata M, Dalman RL Tags: Curr Drug Targets Source Type: research

p53 as the focus of gene therapy: past, present and future.
CONCLUSION: This review summarizes the different methods used to deliver and/or target the p53 as well as the main results of therapeutic effect obtained with the different strategies applied. Finally, the ongoing approaches are described, also focusing the combinatorial therapeutics to show the increased therapeutic potential of combining gene therapy vectors with chemo or radiotherapy. PMID: 29336259 [PubMed - as supplied by publisher] (Source: Current Drug Targets)
Source: Current Drug Targets - January 15, 2018 Category: Drugs & Pharmacology Authors: Valente JF, Queiroz JA, Sousa F Tags: Curr Drug Targets Source Type: research

Adipocytes and abdominal aortic aneurysm: Putative potential role of adipocytes in the process of AAA development.
Conclusion Adipocytes in the vascular wall could be novel targets for the development of AAA therapeutic drugs. PMID: 29336260 [PubMed - as supplied by publisher] (Source: Current Drug Targets)
Source: Current Drug Targets - January 15, 2018 Category: Drugs & Pharmacology Authors: Kugo H, Moriyama T, Zaima N Tags: Curr Drug Targets Source Type: research

The role of DNA repair pathways in AML chemosensitivity.
CONCLUSION: This review highlights that abnormalities in DNA repair mechanisms in AML cells are potential novel treatment targets for AML patients with disease that is resistant to current therapies. PMID: 29318968 [PubMed - as supplied by publisher] (Source: Current Drug Targets)
Source: Current Drug Targets - January 9, 2018 Category: Drugs & Pharmacology Authors: Pearsall EA, Lincz LF, Skelding KA Tags: Curr Drug Targets Source Type: research

Aptamers and aptasensors as novel approach for microbial detection and identification: An appraisal.
Abstract Tremendous efforts through dedicated research have been made for the development of robust, point of care, portable, cost effective, sensitive and specific assays of microbial detection for a wide range of applications. Biosensing and nanotechnology offer novel strategies of designing state of the art devices and assay formats with enhanced sensitivity and all other desired features. Monoclonal antibodies have been in use as biorecognition elements for decades. However, recent studies have demonstrated superiority of aptamers to monoclonal antibodies in a number of applications. Many of the research group...
Source: Current Drug Targets - January 4, 2018 Category: Drugs & Pharmacology Authors: Jamil B, Syed MA Tags: Curr Drug Targets Source Type: research

Significance of hepatoprotective liver specific targeted drug delivery: A review on novel herbal and formulation approaches in management of hepatotoxicity.
CONCLUSION: All over the world millions of people are affected by serious liver disorders which are very difficult to treat despite of many efforts. Hepatotoxicity is one of the major reasons behind drugs continue to be taken off from the market. This review highlights the potential of various phytochemicals as hepatoprotective agent and various strategies which have been proposed to achieve liver targeting, includes passive accumulation of therapeutic drug delivery system and active targeting by surface modifications of particulate formulation with specific ligands. PMID: 29299986 [PubMed - as supplied by publisher] ...
Source: Current Drug Targets - January 3, 2018 Category: Drugs & Pharmacology Authors: Rohilla S, Bhatt DC Tags: Curr Drug Targets Source Type: research

Therapeutic applications of prostaglandins and thromboxane A2 inhibitors in abdominal aortic aneurysms.
san N Abstract Abdominal aortic aneurysm (AAA) is one of the leading causes of death in western countries. Surgery is still, at the present time, the sole treatment that has however a significant mortality and cost rate. Many pharmacological agents are under investigation aiming to reduce growth and prevent AAA rupture. These drugs target different pathological pathways and, notably, the excessive production of prostanoids by cyclooxygenases (COX). Intra-aneurysmal thrombus plays an adverse key role in the progression of AAA, platelets being a primary source of prostanoids as thromboxane A2. In this review, we sum...
Source: Current Drug Targets - December 27, 2017 Category: Drugs & Pharmacology Authors: Audrey C, Georgios M, Jean-Paul CB, Audrey P, Bernard P, Dogné JM, Hanson J, Jean-Olivier D, Pierre D, Sakalihasan N Tags: Curr Drug Targets Source Type: research

Current Status and Perspectives on Pharmacologic Therapy for Abdominal Aortic Aneurysm.
Abstract Abdominal aortic aneurysm (AAA), a common disease involving the segmental expansion and rupture of the aorta, has a high mortality rate. Therapeutic options for AAA are currently limited to surgical repair to prevent catastrophic rupture. Non-surgical approaches, particularly pharmacotherapy, are lacking for the treatment of AAA. Here, we review both basic and clinical studies and discuss the current challenges to developing medical therapy that reduces AAA progression. Studies using animal models of AAA progression and human AAA explant cultures have identified several potential targets for preventing AA...
Source: Current Drug Targets - December 27, 2017 Category: Drugs & Pharmacology Authors: Yoshimura K, Morikage N, Nishino-Fujimoto S, Furutani A, Shirasawa B, Hamano K Tags: Curr Drug Targets Source Type: research

Optimal time for pharmacological treatment of abdominal aortic aneurysm.
Abstract Abdominal aortic aneurysm (AAA), if left untreated, poses the main risks of progressive expansion, rupture, and hemorrhage, leading to death. Smoking and hypertension are the 2 major risk factors for AAA crucial in preventing its progression. The underlying fundamental pathophysiological cause of AAA is chronic inflammation. Large AAA with a risk of rupture is usually treated by graft replacement or endovascular aneurysm repair. Nonsurgical treatment is not an alternative for large AAA, but is potentially beneficial for small AAA which usually requires a watchful waiting approach with medication. Herein, ...
Source: Current Drug Targets - December 27, 2017 Category: Drugs & Pharmacology Authors: Iida Y, Sawa S, Shimizu H Tags: Curr Drug Targets Source Type: research

Fenofibrate and telmisartan in the management of abdominal aortic aneurysm.
Conclusions Fenofibrate and telmisartan have potential as repurposed medications to limit AAA growth and randomized trials for further assessment in AAA patients are ongoing. PMID: 29284388 [PubMed - as supplied by publisher] (Source: Current Drug Targets)
Source: Current Drug Targets - December 27, 2017 Category: Drugs & Pharmacology Authors: Rowbotham SE, Krishna SM, Moran CS, Golledge J Tags: Curr Drug Targets Source Type: research

Efficacy and safety of serotonin receptor ligands in the treatment of irritable bowel syndrome: a review.
This article focuses on the role of serotonin system in the pathophysiology of IBS as a potential therapeutical target. We shortly describe several molecules, associated with serotonin receptors, mainly 5-HT3 receptor antagonists and 5-HT4 receptor agonists, that are used in the treatment of motility disorders and visceral pain in IBS patients. We summarize the findings obtained in the clinical trials and elaborate on the safety of the serotonin ligands. Although the majority of serotonin receptor ligands relieve global symptoms, there are also some adverse effects, which can be dangerous for patients. We postulate that cu...
Source: Current Drug Targets - December 27, 2017 Category: Drugs & Pharmacology Authors: Binienda A, Storr M, Fichna J, Salaga M Tags: Curr Drug Targets Source Type: research

Silk Fibroin based Drug Delivery Applications: Promises and Challenges.
Abstract BACKGROUND: Silk Fibroin (SF), a natural source material obtained from Bombyx mori, has been widely enlisted as biomaterial having outstanding mechanical properties. SF has been reported one of the propitious bio-polymer for various drug delivery systems, as well as drug delivery vehicle. OBJECTIVE: This review is summarised to provide in comprehensive applications of silk fibroin in various drug delivery systems, and also to present the current opportunities and requirements by furnishing a definitive assessment on silk fibroin as a polymer. RESULTS: SF has been reported one of the propitious b...
Source: Current Drug Targets - December 27, 2017 Category: Drugs & Pharmacology Authors: Din Wani SU, Veerabhadrappa GH Tags: Curr Drug Targets Source Type: research

PCSK9 and hypercholesterolemia: Therapeutical approach.
Abstract Despite the intensive research and progress in modern pharmacotherapy, hypercholesterolemia and related cardiovascular complications remain one of the leading causes of mortality and disability in the modern world. A significant contribution to the treatment of hypercholesterolemia was made by the discovery of proprotein convertase subtilisin/kexin type 9 (PCSK9). This enzyme is responsible for the degradation of the low-density lipoprotein (LDL) receptor (LDLR) found at the surface of the plasma membrane in the liver and directly associated with serum LDL level. Limitations in standard therapy used in th...
Source: Current Drug Targets - December 4, 2017 Category: Drugs & Pharmacology Authors: Obradovic M, Zaric B, Sudar-Milovanovic E, Ilincic B, Perovic M, Stokic E, Isenovic E Tags: Curr Drug Targets Source Type: research

Disrupting Acetyl-lysine Interactions: Recent advance in the development of BET inhibitors.
CONCLUSION: Herein, the recent advances reported are reviewed for discovering more excellent small molecule inhibitors. Currently, in addition to compound 4, compounds 7, 22 and 90, have also been into the clinical trial stage. In the view of the outstanding performance of BET inhibitors in anti-tumor, anti-inflammatory and anti-drug resistance, we believe that more and more BET inhibitors will become the new epigenetic therapy for cancer, inflammation and autoimmune disease in clinical practice in the near future. PMID: 29189147 [PubMed - as supplied by publisher] (Source: Current Drug Targets)
Source: Current Drug Targets - November 29, 2017 Category: Drugs & Pharmacology Authors: Zhang F, Ma S Tags: Curr Drug Targets Source Type: research

Identification of novel ligands for therapeutic lipopeptides: daptomycin, surfactin and polymyxin.
The objective of this study was molecular docking of three lipopeptides, daptomycin, surfactin and polymyxin, with their ligands as a means of drug design. Schrödinger software was used for molecular docking of lipopeptides with their corresponding ligands whereas the ligand search was done using RCSB. Once the ligands were identified, they were docked with their corresponding lipopeptide. Docking score and glide energy were used as the parameters to test docking. All four of the identified ligands were found to dock with daptomycin, whereas for both surfactin and polymyxin one out of two ligands docked with the lipop...
Source: Current Drug Targets - November 29, 2017 Category: Drugs & Pharmacology Authors: Jujjavarapu SE, Dhagat S, Kurrey V Tags: Curr Drug Targets Source Type: research

Tocopherol And Tocotrienol: Therapeutic Potential In Animal Models of Stress.
CONCLUSION: This review will reveal the scientific evidence of enteral supplementation of vitamin E in the forms of tocotrienol and tocopherol in animal models of stress. These models mimic the stress endured by critically ill patients in a clinical setting and psychological stress in individuals. Positive outcomes from enteral feeding of vitamin E in reducing the occurrence of stress-induced pathological changes are discussed in this review. These positive findings include their ability to reduced stress-induced gastric ulcers, elevated liver enzymes and improved locomotors activity. Evidences showing tocotrienol and toco...
Source: Current Drug Targets - November 22, 2017 Category: Drugs & Pharmacology Authors: Azlina MFN, Kamisah Y, Qodriyah MS Tags: Curr Drug Targets Source Type: research

Epigenetic mechanisms: Role in hematopoietic stem cell lineage commitment and differentiation.
Abstract Major breakthroughs in last several decades have contributed to our knowledge of the genetic regulation in development. Although epigenetics is not a new concept, unfortunately, the role of epigenetics has not come to fruition in large past. But the field of epigenetics has exploded within the past decade. Now, growing evidences show a complex network of epigenetic regulation in development. The epigenetic makeup of a cell, tissue or individual is much more complex than their genetic complement. Epigenetic modifications are more important for normal development by maintaining the gene expression pattern i...
Source: Current Drug Targets - November 22, 2017 Category: Drugs & Pharmacology Authors: Raghuwanshi S, Dahariya S, Kandi R, Gutti U, Undi RB, Sharma DS, Kovuru N, Sahu I, Yarla NS, Saladi RGV, Gutti RK Tags: Curr Drug Targets Source Type: research

Dopamine: Agonists and Neurodegenerative Disorders.
Abstract Parkinson's disease (PD) is a neurodegenerative disease characterized by the loss of dopaminergic neurons within the substantia nigra pars compacta. Despite of many researches, there is still no cure for this disease. Levodopa is first line treatment of PD, but the long term use of it leads to motor impairments and dyskinesias. The dopamine agonists are the preferred choice for the treatment of PD. They are neuroprotective in nature but also have side effects. In this review, we highlighted the metabolism of dopamine, different types of dopamine agonists with their properties and possible side effects. ...
Source: Current Drug Targets - November 17, 2017 Category: Drugs & Pharmacology Authors: Khanam S, Siddique YH Tags: Curr Drug Targets Source Type: research

Novel Functions of MicroRNA-17-92 Cluster in the Endocrine System.
CONCLUSION: Growing evidence indicates that miR-17-92 cluster plays significant roles in bone, lipid and glucose metabolisms through a variety of signaling pathways. Fully understanding its modulating mechanisms may necessarily facilitate to comprehend the clinical and molecule features of some metabolic disorders such as osteoporosis, arthrosclerosis and diabetes mellitus. It may provide new drug targets to prevent and cure these disorders. PMID: 29149826 [PubMed - as supplied by publisher] (Source: Current Drug Targets)
Source: Current Drug Targets - November 17, 2017 Category: Drugs & Pharmacology Authors: Wan S, Chen X, He Y, Yu X Tags: Curr Drug Targets Source Type: research

Therapeutic Applications of Capsaicin in Upper Airways.
Abstract Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is the substance responsible of the irritation caused by the contact of chili peppers with the skin or mucous membranes. This protoalkaloid acts by stimulating the transient receptor potential cation channel subfamily V member 1 (TRPV1), which is mainly expressed by nociceptive fibers of peripheral sensory neurons, but is also present in the central nervous system, and in some non-neuronal cells. Following the initial, intense neuronal excitation, a brief refractory period occurs. However, repeated and massive exposures to capsaicin can impair nociceptive fiber...
Source: Current Drug Targets - November 17, 2017 Category: Drugs & Pharmacology Authors: Cavaliere C, Masieri S, Cavaliere F Tags: Curr Drug Targets Source Type: research

Vortioxetine Treatment for Anxiety Disorder: A Meta-Analysis Study.
Abstract BACKGROUND: Vortioxetine is a multimodal antidepressant that has been developed for the treatment of major depressive and anxiety disorders. The aim of this review is to quantitatively synthesize all data of the efficacy, safety and tolerability of Vortioxetine in treating anxiety disorder. METHOD: Terms of "Vortioxetine" OR "LuAA21004" AND "anxiety" OR "fear" OR "panic" OR "phobia" were searched. A total of two phase II and five phase III clinical trials were found. RESULTS: Vortioxetine was overall superior to placebo in terms of the ...
Source: Current Drug Targets - November 17, 2017 Category: Drugs & Pharmacology Authors: Yee A, Ng CG, Seng LH Tags: Curr Drug Targets Source Type: research

Current theories and clinical trial evidence for limiting human abdominal aortic aneurysm growth.
CONCLUSIONS: Further randomized, controlled, clinical trials are required to develop effective nonsurgical therapies for AAA. PMID: 29141546 [PubMed - as supplied by publisher] (Source: Current Drug Targets)
Source: Current Drug Targets - November 12, 2017 Category: Drugs & Pharmacology Authors: Yu J, Liu S, Huang J, Wang W Tags: Curr Drug Targets Source Type: research

Main Isoflavones Found in Dietary Sources as Natural Anti-inflammatory Agents.
CONCLUSION: The review concludes that the main isoflavones in dietary sources present in vitro and/or in vivo anti inflammatory potential by activating various biochemical and molecular mechanisms. The depicted findings translated into practical aspects strength the idea that the isoflavones genistein, daidzein, glycitein, biochanin A, formononetin and equol can be used in various inflammation based diseases as an alternative source for classical medication and that consummation of foods rich in isoflavones may represent prerequisite used in order to prevent respectively to decrease the evolution of inflammation based dise...
Source: Current Drug Targets - November 9, 2017 Category: Drugs & Pharmacology Authors: Danciu C, Avram S, Pavel I, Ghiulai R, Dehelean C, Ersilia A, Minda D, Petrescu C, Moaca E, Soica C Tags: Curr Drug Targets Source Type: research

Macrophage Polarization as a Therapeutic Target in Myocardial Infarction.
CONCLUSION: Macrophage polarization deserves better investigations as the therapeutic target for the development of novel drugs against myocardial injury. PMID: 29086692 [PubMed - as supplied by publisher] (Source: Current Drug Targets)
Source: Current Drug Targets - October 31, 2017 Category: Drugs & Pharmacology Authors: Cheng Y, Rong J Tags: Curr Drug Targets Source Type: research

Editorial: "Phytochemicals for Human Diseases: An Update".
Editorial: "Phytochemicals for Human Diseases: An Update". Curr Drug Targets. 2017;18(13):1467 Authors: Nabavi SM, Daglia M PMID: 29070008 [PubMed - in process] (Source: Current Drug Targets)
Source: Current Drug Targets - October 28, 2017 Category: Drugs & Pharmacology Authors: Nabavi SM, Daglia M Tags: Curr Drug Targets Source Type: research

Editorial: New Therapetic Approaches in the Management of Ischemia Reperfusion Injury and Cardiometabolic Diseases: Opportunities and Challenges.
PMID: 29070009 [PubMed - in process] (Source: Current Drug Targets)
Source: Current Drug Targets - October 28, 2017 Category: Drugs & Pharmacology Authors: Ren J, Zhang Y Tags: Curr Drug Targets Source Type: research