Syndecan-1: A Novel Diagnostic and Therapeutic Target in Liver Diseases
Curr Drug Targets. 2023 Nov 7. doi: 10.2174/0113894501250057231102061624. Online ahead of print.ABSTRACTSyndecan-1 (SDC-1), known as a coreceptor of various growth factors or an integrin binding partner, regulates various cell behaviours. Under certain pathological conditions, SDC-1 is shed from the cell surface and plays a protective or pathogenic role in various diseases. In the liver, SDC-1 is highly expressed in hepatocytes, where it is localized on the basolateral surface. It is critical to the cellular and molecular functions of hepatocytes, including their attachment to hepatitis viruses. Previous studies have repor...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Xiaoli Zhang Yalei Zhao Liangru Liu Yingli He Source Type: research

Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing
Curr Drug Targets. 2023 Nov 9. doi: 10.2174/0113894501260002231101080505. Online ahead of print.ABSTRACTThe diabetic wound is excessively vulnerable to infection because the diabetic wound suggests delayed and incomplete healing techniques. Presently, wounds and ulcers related to diabetes have additionally increased the medical burden. A diabetic wound can impair mobility, lead to amputations, or even death. In recent times, advanced drug delivery systems have emerged as promising approaches for enhancing the efficacy of wound healing treatments in diabetic patients. This review aims to provide an overview of the current a...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Harish Bhardwaj Sulekha Khute Ram Sahu Rajendra Kumar Jangde Source Type: research

Radical Scavenging, Anti-Inflammatory, and Hepatoprotective Activities of Pentacyclic Triterpene isolated from Rosa webbiana
CONCLUSION: The compound ARW1 exhibited anti-radical, anti-inflammatory and hepatoprotective effects. The anti-inflammatory and hepatoprotective activities may be attributed to anti-oxidant potential of the compound.PMID:37957908 | DOI:10.2174/0113894501261030231101184216 (Source: Current Drug Targets)
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Abdullah Khan Mir Azam Khan Achyut Adhikari Source Type: research

Syndecan-1: A Novel Diagnostic and Therapeutic Target in Liver Diseases
Curr Drug Targets. 2023 Nov 7. doi: 10.2174/0113894501250057231102061624. Online ahead of print.ABSTRACTSyndecan-1 (SDC-1), known as a coreceptor of various growth factors or an integrin binding partner, regulates various cell behaviours. Under certain pathological conditions, SDC-1 is shed from the cell surface and plays a protective or pathogenic role in various diseases. In the liver, SDC-1 is highly expressed in hepatocytes, where it is localized on the basolateral surface. It is critical to the cellular and molecular functions of hepatocytes, including their attachment to hepatitis viruses. Previous studies have repor...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Xiaoli Zhang Yalei Zhao Liangru Liu Yingli He Source Type: research

Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing
Curr Drug Targets. 2023 Nov 9. doi: 10.2174/0113894501260002231101080505. Online ahead of print.ABSTRACTThe diabetic wound is excessively vulnerable to infection because the diabetic wound suggests delayed and incomplete healing techniques. Presently, wounds and ulcers related to diabetes have additionally increased the medical burden. A diabetic wound can impair mobility, lead to amputations, or even death. In recent times, advanced drug delivery systems have emerged as promising approaches for enhancing the efficacy of wound healing treatments in diabetic patients. This review aims to provide an overview of the current a...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Harish Bhardwaj Sulekha Khute Ram Sahu Rajendra Kumar Jangde Source Type: research

Radical Scavenging, Anti-Inflammatory, and Hepatoprotective Activities of Pentacyclic Triterpene isolated from Rosa webbiana
CONCLUSION: The compound ARW1 exhibited anti-radical, anti-inflammatory and hepatoprotective effects. The anti-inflammatory and hepatoprotective activities may be attributed to anti-oxidant potential of the compound.PMID:37957908 | DOI:10.2174/0113894501261030231101184216 (Source: Current Drug Targets)
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Abdullah Khan Mir Azam Khan Achyut Adhikari Source Type: research

Syndecan-1: A Novel Diagnostic and Therapeutic Target in Liver Diseases
Curr Drug Targets. 2023 Nov 7. doi: 10.2174/0113894501250057231102061624. Online ahead of print.ABSTRACTSyndecan-1 (SDC-1), known as a coreceptor of various growth factors or an integrin binding partner, regulates various cell behaviours. Under certain pathological conditions, SDC-1 is shed from the cell surface and plays a protective or pathogenic role in various diseases. In the liver, SDC-1 is highly expressed in hepatocytes, where it is localized on the basolateral surface. It is critical to the cellular and molecular functions of hepatocytes, including their attachment to hepatitis viruses. Previous studies have repor...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Xiaoli Zhang Yalei Zhao Liangru Liu Yingli He Source Type: research

Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing
Curr Drug Targets. 2023 Nov 9. doi: 10.2174/0113894501260002231101080505. Online ahead of print.ABSTRACTThe diabetic wound is excessively vulnerable to infection because the diabetic wound suggests delayed and incomplete healing techniques. Presently, wounds and ulcers related to diabetes have additionally increased the medical burden. A diabetic wound can impair mobility, lead to amputations, or even death. In recent times, advanced drug delivery systems have emerged as promising approaches for enhancing the efficacy of wound healing treatments in diabetic patients. This review aims to provide an overview of the current a...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Harish Bhardwaj Sulekha Khute Ram Sahu Rajendra Kumar Jangde Source Type: research

Radical Scavenging, Anti-Inflammatory, and Hepatoprotective Activities of Pentacyclic Triterpene isolated from Rosa webbiana
CONCLUSION: The compound ARW1 exhibited anti-radical, anti-inflammatory and hepatoprotective effects. The anti-inflammatory and hepatoprotective activities may be attributed to anti-oxidant potential of the compound.PMID:37957908 | DOI:10.2174/0113894501261030231101184216 (Source: Current Drug Targets)
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Abdullah Khan Mir Azam Khan Achyut Adhikari Source Type: research

Syndecan-1: A Novel Diagnostic and Therapeutic Target in Liver Diseases
Curr Drug Targets. 2023 Nov 7. doi: 10.2174/0113894501250057231102061624. Online ahead of print.ABSTRACTSyndecan-1 (SDC-1), known as a coreceptor of various growth factors or an integrin binding partner, regulates various cell behaviours. Under certain pathological conditions, SDC-1 is shed from the cell surface and plays a protective or pathogenic role in various diseases. In the liver, SDC-1 is highly expressed in hepatocytes, where it is localized on the basolateral surface. It is critical to the cellular and molecular functions of hepatocytes, including their attachment to hepatitis viruses. Previous studies have repor...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Xiaoli Zhang Yalei Zhao Liangru Liu Yingli He Source Type: research

Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing
Curr Drug Targets. 2023 Nov 9. doi: 10.2174/0113894501260002231101080505. Online ahead of print.ABSTRACTThe diabetic wound is excessively vulnerable to infection because the diabetic wound suggests delayed and incomplete healing techniques. Presently, wounds and ulcers related to diabetes have additionally increased the medical burden. A diabetic wound can impair mobility, lead to amputations, or even death. In recent times, advanced drug delivery systems have emerged as promising approaches for enhancing the efficacy of wound healing treatments in diabetic patients. This review aims to provide an overview of the current a...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Harish Bhardwaj Sulekha Khute Ram Sahu Rajendra Kumar Jangde Source Type: research

Radical Scavenging, Anti-Inflammatory, and Hepatoprotective Activities of Pentacyclic Triterpene isolated from Rosa webbiana
CONCLUSION: The compound ARW1 exhibited anti-radical, anti-inflammatory and hepatoprotective effects. The anti-inflammatory and hepatoprotective activities may be attributed to anti-oxidant potential of the compound.PMID:37957908 | DOI:10.2174/0113894501261030231101184216 (Source: Current Drug Targets)
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Abdullah Khan Mir Azam Khan Achyut Adhikari Source Type: research

Syndecan-1: A Novel Diagnostic and Therapeutic Target in Liver Diseases
Curr Drug Targets. 2023 Nov 7. doi: 10.2174/0113894501250057231102061624. Online ahead of print.ABSTRACTSyndecan-1 (SDC-1), known as a coreceptor of various growth factors or an integrin binding partner, regulates various cell behaviours. Under certain pathological conditions, SDC-1 is shed from the cell surface and plays a protective or pathogenic role in various diseases. In the liver, SDC-1 is highly expressed in hepatocytes, where it is localized on the basolateral surface. It is critical to the cellular and molecular functions of hepatocytes, including their attachment to hepatitis viruses. Previous studies have repor...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Yingli He Xiaoli Zhang Yalei Zhao Liangru Liu Source Type: research

Advanced Drug Delivery System for Management of Chronic Diabetes Wound Healing
Curr Drug Targets. 2023 Nov 9. doi: 10.2174/0113894501260002231101080505. Online ahead of print.ABSTRACTThe diabetic wound is excessively vulnerable to infection because the diabetic wound suggests delayed and incomplete healing techniques. Presently, wounds and ulcers related to diabetes have additionally increased the medical burden. A diabetic wound can impair mobility, lead to amputations, or even death. In recent times, advanced drug delivery systems have emerged as promising approaches for enhancing the efficacy of wound healing treatments in diabetic patients. This review aims to provide an overview of the current a...
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Harish Bhardwaj Sulekha Khute Ram Kumar Sahu Rajendra Kumar Jangde Source Type: research

Radical Scavenging, Anti-Inflammatory, and Hepatoprotective Activities of Pentacyclic Triterpene isolated from Rosa webbiana
CONCLUSION: The compound ARW1 exhibited anti-radical, anti-inflammatory and hepatoprotective effects. The anti-inflammatory and hepatoprotective activities may be attributed to anti-oxidant potential of the compound.PMID:37957908 | DOI:10.2174/0113894501261030231101184216 (Source: Current Drug Targets)
Source: Current Drug Targets - November 14, 2023 Category: Drugs & Pharmacology Authors: Abdullah Khan Mir Azam Khan Achyut Adhikari Source Type: research