Recent Update on the Alzheimer's Disease Progression, Diagnosis and Treatment Approaches
Curr Drug Targets. 2022 May 31. doi: 10.2174/1389450123666220526155144. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a multifactorial, progressive, neurodegenerative disorder, manifested by the loss of memory and cognitive abilities, behavioral disturbance and progressive impairment of activities of daily life. The sharp rise in the number of AD patients has brought it with-in the top eight health issues in the world. It is associated with the distribution of misfolded aggre-gates of protein within the brain. However, Alois Alzheimer initially mentioned that the reduction in brain volume in AD might be associa...
Source: Current Drug Targets - June 3, 2022 Category: Drugs & Pharmacology Authors: Akanksha Malaiya Mansha Singhai Manisha Singh Shiv Kumar Prajapati Hira Choudhury Mahak Fatima Amit Alexander Sunil Kumar Dubey Khaled Greish Prashant Kesharwani Source Type: research

Recent Update on the Alzheimer's Disease Progression, Diagnosis and Treatment Approaches
Curr Drug Targets. 2022 May 31. doi: 10.2174/1389450123666220526155144. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a multifactorial, progressive, neurodegenerative disorder, manifested by the loss of memory and cognitive abilities, behavioral disturbance and progressive impairment of activities of daily life. The sharp rise in the number of AD patients has brought it with-in the top eight health issues in the world. It is associated with the distribution of misfolded aggre-gates of protein within the brain. However, Alois Alzheimer initially mentioned that the reduction in brain volume in AD might be associa...
Source: Current Drug Targets - June 3, 2022 Category: Drugs & Pharmacology Authors: Akanksha Malaiya Mansha Singhai Manisha Singh Shiv Kumar Prajapati Hira Choudhury Mahak Fatima Amit Alexander Sunil Kumar Dubey Khaled Greish Prashant Kesharwani Source Type: research

Recent Update on the Alzheimer's Disease Progression, Diagnosis and Treatment Approaches
Curr Drug Targets. 2022 May 31. doi: 10.2174/1389450123666220526155144. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a multifactorial, progressive, neurodegenerative disorder, manifested by the loss of memory and cognitive abilities, behavioral disturbance and progressive impairment of activities of daily life. The sharp rise in the number of AD patients has brought it with-in the top eight health issues in the world. It is associated with the distribution of misfolded aggre-gates of protein within the brain. However, Alois Alzheimer initially mentioned that the reduction in brain volume in AD might be associa...
Source: Current Drug Targets - June 3, 2022 Category: Drugs & Pharmacology Authors: Akanksha Malaiya Mansha Singhai Manisha Singh Shiv Kumar Prajapati Hira Choudhury Mahak Fatima Amit Alexander Sunil Kumar Dubey Khaled Greish Prashant Kesharwani Source Type: research

Recent Update on the Alzheimer's Disease Progression, Diagnosis and Treatment Approaches
Curr Drug Targets. 2022 May 31. doi: 10.2174/1389450123666220526155144. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a multifactorial, progressive, neurodegenerative disorder, manifested by the loss of memory and cognitive abilities, behavioral disturbance and progressive impairment of activities of daily life. The sharp rise in the number of AD patients has brought it with-in the top eight health issues in the world. It is associated with the distribution of misfolded aggre-gates of protein within the brain. However, Alois Alzheimer initially mentioned that the reduction in brain volume in AD might be associa...
Source: Current Drug Targets - June 3, 2022 Category: Drugs & Pharmacology Authors: Akanksha Malaiya Mansha Singhai Manisha Singh Shiv Kumar Prajapati Hira Choudhury Mahak Fatima Amit Alexander Sunil Kumar Dubey Khaled Greish Prashant Kesharwani Source Type: research

Vascular Endothelial Dysfunction in Ischemic Reperfusion Injury Needs Constant Updating
Curr Drug Targets. 2022 May 19. doi: 10.2174/1389450123666220519170221. Online ahead of print.NO ABSTRACTPMID:35619292 | DOI:10.2174/1389450123666220519170221 (Source: Current Drug Targets)
Source: Current Drug Targets - May 27, 2022 Category: Drugs & Pharmacology Authors: Ricardo Oliveira Dos Santos Soares Agnes Afrodite Sumarelli Albuquerque Paulo Roberto Barbosa Evora Source Type: research

Vascular Endothelial Dysfunction in Ischemic Reperfusion Injury Needs Constant Updating
Curr Drug Targets. 2022 May 19. doi: 10.2174/1389450123666220519170221. Online ahead of print.NO ABSTRACTPMID:35619292 | DOI:10.2174/1389450123666220519170221 (Source: Current Drug Targets)
Source: Current Drug Targets - May 27, 2022 Category: Drugs & Pharmacology Authors: Ricardo Oliveira Dos Santos Soares Agnes Afrodite Sumarelli Albuquerque Paulo Roberto Barbosa Evora Source Type: research

Vascular Endothelial Dysfunction in Ischemic Reperfusion Injury Needs Constant Updating
Curr Drug Targets. 2022 May 19. doi: 10.2174/1389450123666220519170221. Online ahead of print.NO ABSTRACTPMID:35619292 | DOI:10.2174/1389450123666220519170221 (Source: Current Drug Targets)
Source: Current Drug Targets - May 27, 2022 Category: Drugs & Pharmacology Authors: Ricardo Oliveira Dos Santos Soares Agnes Afrodite Sumarelli Albuquerque Paulo Roberto Barbosa Evora Source Type: research

Vascular Endothelial Dysfunction in Ischemic Reperfusion Injury Needs Constant Updating
Curr Drug Targets. 2022 May 19. doi: 10.2174/1389450123666220519170221. Online ahead of print.NO ABSTRACTPMID:35619292 | DOI:10.2174/1389450123666220519170221 (Source: Current Drug Targets)
Source: Current Drug Targets - May 27, 2022 Category: Drugs & Pharmacology Authors: Ricardo Oliveira Dos Santos Soares Agnes Afrodite Sumarelli Albuquerque Paulo Roberto Barbosa Evora Source Type: research

Vascular Endothelial Dysfunction in Ischemic Reperfusion Injury Needs Constant Updating
Curr Drug Targets. 2022 May 19. doi: 10.2174/1389450123666220519170221. Online ahead of print.NO ABSTRACTPMID:35619292 | DOI:10.2174/1389450123666220519170221 (Source: Current Drug Targets)
Source: Current Drug Targets - May 27, 2022 Category: Drugs & Pharmacology Authors: Ricardo Oliveira Dos Santos Soares Agnes Afrodite Sumarelli Albuquerque Paulo Roberto Barbosa Evora Source Type: research

Vascular Endothelial Dysfunction in Ischemic Reperfusion Injury Needs Constant Updating
Curr Drug Targets. 2022 May 19. doi: 10.2174/1389450123666220519170221. Online ahead of print.NO ABSTRACTPMID:35619292 | DOI:10.2174/1389450123666220519170221 (Source: Current Drug Targets)
Source: Current Drug Targets - May 27, 2022 Category: Drugs & Pharmacology Authors: Ricardo Oliveira Dos Santos Soares Agnes Afrodite Sumarelli Albuquerque Paulo Roberto Barbosa Evora Source Type: research

Microbubbles Contrast Agents: General Overview as Diagnostics and Therapeutic Agent
Curr Drug Targets. 2022 Apr 21. doi: 10.2174/1573399818666220421123142. Online ahead of print.ABSTRACTRecent discoveries have unfolded many powerful emerging applications in the field of drug delivery science. For the past few years, ultrasound mediated microbubble contrast agents have been an emerging modality for diagnostic and drug delivery applications. Microbubbles are small spherical bubbles composed of a gas core encapsulated by a shell with different materials. The composition of the microbubble determines its stiffness, encapsulation efficiency, stability, and clearance from the system. A gas-filled microbubble, w...
Source: Current Drug Targets - May 20, 2022 Category: Drugs & Pharmacology Authors: Shivani K Gharat Shilpa C Godiyal Pranali P Malusare Kisan R Jadhav Vilasrao J Kadam Source Type: research

Amyloid-beta targeted therapeutic approaches for Alzheimer's disease: long road ahead
Curr Drug Targets. 2022 Apr 21. doi: 10.2174/1389450123666220421124030. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a progressive neurodegenerative disorder which is characterized by memory impairment and cognitive decline. The obvious pathological features of AD are still amyloid plaques and neurofibrillary tangles. Development of disease-modifying treatments for AD has been challenging, with almost all drugs aborted. The failures of several amyloid-targeting candidates have caused the amyloid cascade hypothesis has been distrusted. Despite this, targeting amyloid-β (Aβ) active immunotherapy provided some ...
Source: Current Drug Targets - May 20, 2022 Category: Drugs & Pharmacology Authors: Yuxuan Dai Chenyi Lei Zhenhao Zhang Yan Qi Kejing Lao Xingchun Gou Source Type: research

Clinical Combinatorial Treatments Based on Cancer Vaccines: Combination with Checkpoint Inhibitors and Beyond
Curr Drug Targets. 2022 Apr 21. doi: 10.2174/1389450123666220421124542. Online ahead of print.ABSTRACTCancer vaccine efficacy is influenced by several factors, but one of the most important is the immunosuppressive tumor microenvironment, which can attenuate treatment effects. The combination of therapeutic cancer vaccines with other immunotherapies or conventional therapeutic approaches can promote vaccine efficacy by increasing immune surveillance and tumor immunogenicity and modulating immune escape in the tumor microenvironment. Inhibitory checkpoints have a significant role in the modulation of anticancer immune respo...
Source: Current Drug Targets - May 20, 2022 Category: Drugs & Pharmacology Authors: Mojdeh Soltani Lyudmila V Savvateeva Mazdak Ganjalikhani-Hakemi Andrey A Zamyatnin Source Type: research

Microbubbles Contrast Agents: General Overview as Diagnostics and Therapeutic Agent
Curr Drug Targets. 2022 Apr 21. doi: 10.2174/1573399818666220421123142. Online ahead of print.ABSTRACTRecent discoveries have unfolded many powerful emerging applications in the field of drug delivery science. For the past few years, ultrasound mediated microbubble contrast agents have been an emerging modality for diagnostic and drug delivery applications. Microbubbles are small spherical bubbles composed of a gas core encapsulated by a shell with different materials. The composition of the microbubble determines its stiffness, encapsulation efficiency, stability, and clearance from the system. A gas-filled microbubble, w...
Source: Current Drug Targets - May 20, 2022 Category: Drugs & Pharmacology Authors: Shivani K Gharat Shilpa C Godiyal Pranali P Malusare Kisan R Jadhav Vilasrao J Kadam Source Type: research

Amyloid-beta targeted therapeutic approaches for Alzheimer's disease: long road ahead
Curr Drug Targets. 2022 Apr 21. doi: 10.2174/1389450123666220421124030. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a progressive neurodegenerative disorder which is characterized by memory impairment and cognitive decline. The obvious pathological features of AD are still amyloid plaques and neurofibrillary tangles. Development of disease-modifying treatments for AD has been challenging, with almost all drugs aborted. The failures of several amyloid-targeting candidates have caused the amyloid cascade hypothesis has been distrusted. Despite this, targeting amyloid-β (Aβ) active immunotherapy provided some ...
Source: Current Drug Targets - May 20, 2022 Category: Drugs & Pharmacology Authors: Yuxuan Dai Chenyi Lei Zhenhao Zhang Yan Qi Kejing Lao Xingchun Gou Source Type: research