Effect of Rotenone on the Neurodegeneration among Different Models

Curr Drug Targets. 2024 May 2. doi: 10.2174/0113894501281496231226070459. Online ahead of print.ABSTRACTRotenone is a naturally occurring plant product used as an insecticide, pesticide and piscicide. It is lipophilic in nature and can cross the blood-brain barrier and induce the degeneration of neurons. It inhibits the mitochondrial respiratory chain complex I and stops the transfer of electrons. It induces ROS generation, which impairs mitochondrial activity. Rotenone is a toxic agent which causes the death of neurons. The present review describes the effect of rotenone on neurodegeneration with an emphasis on behavioral, pathological and neuropathological components carried out on various experimental models such as cell lines, Drosophila melanogaster, mice and rats.PMID:38698744 | DOI:10.2174/0113894501281496231226070459
Source: Current Drug Targets - Category: Drugs & Pharmacology Authors: Source Type: research