Endothelial Cellular Senescence Contributes to Loss of Capillary Density
The consensus of the research community on senescent cells in old tissues is that (a) their presence causes harm, and (b) treatments based on the selective removal of such cells will be beneficial, reversing many aspects of aging and age-related disease. These cells secrete a pro-inflammatory mix of signal molecules that is disruptive to tissue structure and function when maintained over time. Cells become senescent constantly throughout life, only to be destroyed by programmed cell death or by the immune system. With advancing age, newly created senescent cells are cleared ever more slowly, however, and thus the burden of...
Source: Fight Aging! - April 18, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Vitamin Deficiency Linked to Moodiness, Lack Of Motivation And Tiredness
The vitamin may have a direct effect on the brain and has also been linked to Parkinson's disease and dementia. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - April 18, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Mental Health Nutrition Source Type: blogs
Will Artificial Intelligence (AI) Trigger Universal Health Care in America? What do expert Academics say?
By MIKE MAGEE
In his book, “The Age of Diminished Expectations” (MIT Press/1994), Nobel Prize winner, Paul Krugman, famously wrote, “Productivity isn’t everything, but in the long run it is almost everything.”
A year earlier, psychologist Karl E. Weich from the University of Michigan penned the term “sensemaking” based on his belief that the human mind was in fact the engine of productivity, and functioned like a biological computer which “receives input, processes the information, and delivers an output.”
But comparing the human brain to a computer was not exactly a complemen...
Source: The Health Care Blog - April 18, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Tech Bob Wachter Erik Brynjolfsson Karl E. Weich Medical AI Mike Magee Paul Krugman productivity Source Type: blogs
Sea Urchins as a Model of Negligible Senescence
Species that exhibit negligible senescence tend to be long-lived, but more interestingly appear to exhibit few to none of the functional declines of degenerative aging until very late in life, quite unlike the situation for most mammals, and particularly for humans. One can argue that the most useful species that exhibit negligible senescence are those with near relative species that age more normally. The closer the relative, the more likely it is that comparing the biochemistry of the two will lead to new knowledge regarding aging. So naked mole rats versus other, less long-lived mole rats, Brandt's bat versus other shor...
Source: Fight Aging! - April 17, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Population Study Correlates Air Pollution with Faster Cognitive Aging
A number of large epidemiological studies provide evidence for long-term exposure to greater levels of air pollution to accelerate the onset and progression of age-related disease. A few of these manage to control for the tendency for wealthier people to avoid living in areas with higher particulate air pollution, and the correlation with worse health remains. Mechanistically, it is thought that particulates provoke greater chronic inflammation via their interaction with lung and other tissues, and this in turn contributes to the cell and tissue dysfunction that leads to age-related disease.
The present study asse...
Source: Fight Aging! - April 17, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Personality Trait Linked To Good Mental Health
This type of people are less likely to be neurotic. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - April 16, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Personality Source Type: blogs
Difference Between Invasive and Non-Invasive Ventilation
Ventilator is a device used to support breathing. It is used when there is difficulty in breathing or when spontaneous breathing has stopped. Ventilator is an important life supporting device useful in many life threatening conditions.
Invasive ventilator is usually used in the intensive care setting or the operating room. An endotracheal tube is introduced under topical anaesthesia with sedation or general anaesthesia. The endotracheal tube is connected to a mechanical ventilator using appropriate connection tubing. In those who do not tolerate the presence of an endotracheal tube deep sedation and neuromuscular blockade ...
Source: Cardiophile MD - April 16, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Inducing Low Body Temperature via Torpor Slows Aging in Mice
Past evidence has suggested that the lowered body temperature characteristic of calorie restriction is important to the slowed aging that results in short-lived mammals. One might compare that to the strong evidence for upregulated autophagy to be the driving factor in slowed aging produced by the practice of calorie restriction. Researchers here conduct a similar study, inducing a reduction in metabolic rate, dietary intake, and body temperature in mice via activation of a specific brain region. As in past research, the resulting slowed aging was shown to be driven by that lowered body temperature rather than any of the o...
Source: Fight Aging! - April 16, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Herpes Simplex Infection Correlates with Amyloid Burden in the Aging Brain
There is a continuing debate over the degree to which Alzheimer's is driven by persistent infection in brain tissue, such as by varieties of herpesvirus. Amyloid-β is an antimicrobial peptide, a part of the innate immune response, and one could argue that persistently raised expression of amyloid-β will increase misfolding and generation of the aggregates that drive pathology in the early stages of Alzheimer's disease, at least under the amyloid cascade hypothesis. The data is not all convincing, however, which suggests that perhaps there are other factors involved - that multiple viruses interact in some people, for exa...
Source: Fight Aging! - April 15, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
This Natural Juice Helps Keep Your Brain Young (M)
Older brains can perform like younger ones with this supplement. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - April 14, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Boost Brain Power subscribers-only Source Type: blogs
Fight Aging! Newsletter, April 15th 2024
In conclusion, although several clinical trials targeting SnCs are ongoing, various questions about the biology of SnCs remain open, resulting in a gap between molecular and cellular data. Concerning the need, initiatives such as SenNet aiming to create openly accessible atlases of SnCs should contribute enormously to the area. Advances in understanding the subcellular structure, the heterogeneity, and the dynamics of SnCs require the integration of molecular and cellular techniques with data analysis packages to evaluate high throughput evidence from microscopy and flow cytometry. It is also necessary to develop new equip...
Source: Fight Aging! - April 14, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Long-Lived RNA that is Never Replaced in Neurons
The question of whether there are long-lived molecules in long-lived neurons in the brain is an interesting one. Are there specific molecules in the brain that never get replaced across a lifetime, and thus might be vulnerable to damage in the form of modifications that disrupt function? This remains a somewhat hypothetical concern, in the sense that there is no direct demonstration that this is a significant source of dysfunction in late life. Researchers have found evidence for long-lived nuclear pore proteins, however, and here another group presents evidence for long-lived RNA molecules.
Most cells in the huma...
Source: Fight Aging! - April 12, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Pulse of Progress: Looking Back, Moving Forward | TAPP 147
In Episode 147, host Kevin Patton reviews thehighlights and events of theprevious year in theworld of The A&P Professor. He then turns to last year ' s predictions for teaching human anatomy and physiology to see if he was on the right track. Finally,predictions for the coming year are revealed. And lots of other stuff —this episode istwo hours long, after all!0:00:00 | Introduction0:00:50 | Debrief: Topics, Stats, Reflections0:21:28 | A Long, Long, Long Episode0:23:05 | Debrief: More Reviewing& Reflecting0:38:59 | Did I Get My Predictions Right?0:50:22 | Textbook& Academic Authors Association0:57:47 | Lookin...
Source: The A and P Professor - April 12, 2024 Category: Physiology Authors: Kevin Patton Source Type: blogs
The Surprising Benefits Of Daydreaming Revealed (M)
Explore the fascinating overlap between memory and imagination in the brain's default mode network. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - April 11, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Dreams subscribers-only Source Type: blogs
Enabling Microglia to Better Clear Amyloid by Interfering in the LILRB4-APOE Interaction
Researchers here describe a mechanism that reduces the ability of microglia to ingest and clear misfolded amyloid-β, the protein aggregates associated with Alzheimer's disease. Interestingly, this involves APOE, and thus might be affected by the different APOE variants connected to Alzheimer's disease risk. The researchers demonstrate that interfering in the interaction between APOE and the LILRB4 receptor present on microglia can restore microglia-mediated clearance of amyloid-β.
Toxic clumps of brain proteins are features of many neurodegenerative conditions, including Alzheimer's disease (AD), Parkinson's dis...
Source: Fight Aging! - April 11, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
