Cold sensor, hot topic: TRPM8 plays a role in monocyte function and differentiation
J Leukoc Biol. 2022 May 15. doi: 10.1002/JLB.3CE0222-099R. Online ahead of print.ABSTRACTUnderstanding the innate immune system and how aberrant activation or impaired inhibition leads to the development of hyperinflammatory conditions, including inflammatory bowel disease, is crucial for patient management and treatment. An emerging area of interest surrounding dysregulated inflammation focuses on membrane bound transient receptor potential (TRP) ion channels. These channels are permeable to calcium and other cations involved in the balance of leukocyte membrane potential and function, as well as afferent neuron signaling...
Source: Journal of Leukocyte Biology - May 16, 2022 Category: Hematology Authors: Brie Trusiano Juselyn D Tupik Irving C Allen Source Type: research

Relationship and prognostic significance of IL-33, PD-1/PD-L1, and tertiary lymphoid structures in cervical cancer
J Leukoc Biol. 2022 May 2. doi: 10.1002/JLB.5MA0322-746R. Online ahead of print.ABSTRACTIL-33, an epithelial-derived cytokine, functions as an alarmin for the immune system in the tumor microenvironment (TME). However, the expression and role of IL-33 on cervical cancer remain unclear. The aim of this study was to investigate the expression of IL-33 and its relationship with clinicopathologic features, tertiary lymphoid structures (TLS), and programmed cell death 1 (PD-1)/programmed cell death 1 ligand (PD-L1) immune checkpoints by immunohistochemistry in 93 cervical cancer patient specimens. Down-regulation of IL-33 expre...
Source: Journal of Leukocyte Biology - May 2, 2022 Category: Hematology Authors: Ying Zhang Jing Li Fan Yang Xiying Zhang Xiubao Ren Feng Wei Source Type: research

Relationship and prognostic significance of IL-33, PD-1/PD-L1, and tertiary lymphoid structures in cervical cancer
J Leukoc Biol. 2022 May 2. doi: 10.1002/JLB.5MA0322-746R. Online ahead of print.ABSTRACTIL-33, an epithelial-derived cytokine, functions as an alarmin for the immune system in the tumor microenvironment (TME). However, the expression and role of IL-33 on cervical cancer remain unclear. The aim of this study was to investigate the expression of IL-33 and its relationship with clinicopathologic features, tertiary lymphoid structures (TLS), and programmed cell death 1 (PD-1)/programmed cell death 1 ligand (PD-L1) immune checkpoints by immunohistochemistry in 93 cervical cancer patient specimens. Down-regulation of IL-33 expre...
Source: Journal of Leukocyte Biology - May 2, 2022 Category: Hematology Authors: Ying Zhang Jing Li Fan Yang Xiying Zhang Xiubao Ren Feng Wei Source Type: research

Relationship and prognostic significance of IL-33, PD-1/PD-L1, and tertiary lymphoid structures in cervical cancer
J Leukoc Biol. 2022 May 2. doi: 10.1002/JLB.5MA0322-746R. Online ahead of print.ABSTRACTIL-33, an epithelial-derived cytokine, functions as an alarmin for the immune system in the tumor microenvironment (TME). However, the expression and role of IL-33 on cervical cancer remain unclear. The aim of this study was to investigate the expression of IL-33 and its relationship with clinicopathologic features, tertiary lymphoid structures (TLS), and programmed cell death 1 (PD-1)/programmed cell death 1 ligand (PD-L1) immune checkpoints by immunohistochemistry in 93 cervical cancer patient specimens. Down-regulation of IL-33 expre...
Source: Journal of Leukocyte Biology - May 2, 2022 Category: Hematology Authors: Ying Zhang Jing Li Fan Yang Xiying Zhang Xiubao Ren Feng Wei Source Type: research

Relationship and prognostic significance of IL-33, PD-1/PD-L1, and tertiary lymphoid structures in cervical cancer
J Leukoc Biol. 2022 May 2. doi: 10.1002/JLB.5MA0322-746R. Online ahead of print.ABSTRACTIL-33, an epithelial-derived cytokine, functions as an alarmin for the immune system in the tumor microenvironment (TME). However, the expression and role of IL-33 on cervical cancer remain unclear. The aim of this study was to investigate the expression of IL-33 and its relationship with clinicopathologic features, tertiary lymphoid structures (TLS), and programmed cell death 1 (PD-1)/programmed cell death 1 ligand (PD-L1) immune checkpoints by immunohistochemistry in 93 cervical cancer patient specimens. Down-regulation of IL-33 expre...
Source: Journal of Leukocyte Biology - May 2, 2022 Category: Hematology Authors: Ying Zhang Jing Li Fan Yang Xiying Zhang Xiubao Ren Feng Wei Source Type: research

Relationship and prognostic significance of IL-33, PD-1/PD-L1, and tertiary lymphoid structures in cervical cancer
J Leukoc Biol. 2022 May 2. doi: 10.1002/JLB.5MA0322-746R. Online ahead of print.ABSTRACTIL-33, an epithelial-derived cytokine, functions as an alarmin for the immune system in the tumor microenvironment (TME). However, the expression and role of IL-33 on cervical cancer remain unclear. The aim of this study was to investigate the expression of IL-33 and its relationship with clinicopathologic features, tertiary lymphoid structures (TLS), and programmed cell death 1 (PD-1)/programmed cell death 1 ligand (PD-L1) immune checkpoints by immunohistochemistry in 93 cervical cancer patient specimens. Down-regulation of IL-33 expre...
Source: Journal of Leukocyte Biology - May 2, 2022 Category: Hematology Authors: Ying Zhang Jing Li Fan Yang Xiying Zhang Xiubao Ren Feng Wei Source Type: research

Relationship and prognostic significance of IL-33, PD-1/PD-L1, and tertiary lymphoid structures in cervical cancer
J Leukoc Biol. 2022 May 2. doi: 10.1002/JLB.5MA0322-746R. Online ahead of print.ABSTRACTIL-33, an epithelial-derived cytokine, functions as an alarmin for the immune system in the tumor microenvironment (TME). However, the expression and role of IL-33 on cervical cancer remain unclear. The aim of this study was to investigate the expression of IL-33 and its relationship with clinicopathologic features, tertiary lymphoid structures (TLS), and programmed cell death 1 (PD-1)/programmed cell death 1 ligand (PD-L1) immune checkpoints by immunohistochemistry in 93 cervical cancer patient specimens. Down-regulation of IL-33 expre...
Source: Journal of Leukocyte Biology - May 2, 2022 Category: Hematology Authors: Ying Zhang Jing Li Fan Yang Xiying Zhang Xiubao Ren Feng Wei Source Type: research

Relationship and prognostic significance of IL-33, PD-1/PD-L1, and tertiary lymphoid structures in cervical cancer
J Leukoc Biol. 2022 May 2. doi: 10.1002/JLB.5MA0322-746R. Online ahead of print.ABSTRACTIL-33, an epithelial-derived cytokine, functions as an alarmin for the immune system in the tumor microenvironment (TME). However, the expression and role of IL-33 on cervical cancer remain unclear. The aim of this study was to investigate the expression of IL-33 and its relationship with clinicopathologic features, tertiary lymphoid structures (TLS), and programmed cell death 1 (PD-1)/programmed cell death 1 ligand (PD-L1) immune checkpoints by immunohistochemistry in 93 cervical cancer patient specimens. Down-regulation of IL-33 expre...
Source: Journal of Leukocyte Biology - May 2, 2022 Category: Hematology Authors: Ying Zhang Jing Li Fan Yang Xiying Zhang Xiubao Ren Feng Wei Source Type: research

Relationship and prognostic significance of IL-33, PD-1/PD-L1, and tertiary lymphoid structures in cervical cancer
J Leukoc Biol. 2022 May 2. doi: 10.1002/JLB.5MA0322-746R. Online ahead of print.ABSTRACTIL-33, an epithelial-derived cytokine, functions as an alarmin for the immune system in the tumor microenvironment (TME). However, the expression and role of IL-33 on cervical cancer remain unclear. The aim of this study was to investigate the expression of IL-33 and its relationship with clinicopathologic features, tertiary lymphoid structures (TLS), and programmed cell death 1 (PD-1)/programmed cell death 1 ligand (PD-L1) immune checkpoints by immunohistochemistry in 93 cervical cancer patient specimens. Down-regulation of IL-33 expre...
Source: Journal of Leukocyte Biology - May 2, 2022 Category: Hematology Authors: Ying Zhang Jing Li Fan Yang Xiying Zhang Xiubao Ren Feng Wei Source Type: research

Relationship and prognostic significance of IL-33, PD-1/PD-L1, and tertiary lymphoid structures in cervical cancer
J Leukoc Biol. 2022 May 2. doi: 10.1002/JLB.5MA0322-746R. Online ahead of print.ABSTRACTIL-33, an epithelial-derived cytokine, functions as an alarmin for the immune system in the tumor microenvironment (TME). However, the expression and role of IL-33 on cervical cancer remain unclear. The aim of this study was to investigate the expression of IL-33 and its relationship with clinicopathologic features, tertiary lymphoid structures (TLS), and programmed cell death 1 (PD-1)/programmed cell death 1 ligand (PD-L1) immune checkpoints by immunohistochemistry in 93 cervical cancer patient specimens. Down-regulation of IL-33 expre...
Source: Journal of Leukocyte Biology - May 2, 2022 Category: Hematology Authors: Ying Zhang Jing Li Fan Yang Xiying Zhang Xiubao Ren Feng Wei Source Type: research

Relationship and prognostic significance of IL-33, PD-1/PD-L1, and tertiary lymphoid structures in cervical cancer
J Leukoc Biol. 2022 May 2. doi: 10.1002/JLB.5MA0322-746R. Online ahead of print.ABSTRACTIL-33, an epithelial-derived cytokine, functions as an alarmin for the immune system in the tumor microenvironment (TME). However, the expression and role of IL-33 on cervical cancer remain unclear. The aim of this study was to investigate the expression of IL-33 and its relationship with clinicopathologic features, tertiary lymphoid structures (TLS), and programmed cell death 1 (PD-1)/programmed cell death 1 ligand (PD-L1) immune checkpoints by immunohistochemistry in 93 cervical cancer patient specimens. Down-regulation of IL-33 expre...
Source: Journal of Leukocyte Biology - May 2, 2022 Category: Hematology Authors: Ying Zhang Jing Li Fan Yang Xiying Zhang Xiubao Ren Feng Wei Source Type: research

T-Cell Activation and LPS: A Dangerous Duo for Organ Dysfunction
J Leukoc Biol. 2022 Apr 28. doi: 10.1002/JLB.3CE0122-019R. Online ahead of print.ABSTRACTLipopolysaccharide (LPS), one of the main components of cell membranes in gram-negative bacteria, is commonly used to promote inflammation-induced organ dysfunction. In the TLR4/LPS pathway, LPS binding protein and CD14 enable lipid A of LPS to be recognized by the TLR4-MD2 receptor complex. The intracellular domain of the TLR4/LPS complex stimulates MyD88-dependent/independent and TRIF-dependent pathways, which in turn activate NF-B and IRF3, leading to subsequent production of pro-inflammatory mediators. LPS has been demonstrated to ...
Source: Journal of Leukocyte Biology - April 28, 2022 Category: Hematology Authors: Austin W Kerr Philip A Efron Shawn D Larson Jaimar C Rincon Source Type: research

T-Cell Activation and LPS: A Dangerous Duo for Organ Dysfunction
J Leukoc Biol. 2022 Apr 28. doi: 10.1002/JLB.3CE0122-019R. Online ahead of print.ABSTRACTLipopolysaccharide (LPS), one of the main components of cell membranes in gram-negative bacteria, is commonly used to promote inflammation-induced organ dysfunction. In the TLR4/LPS pathway, LPS binding protein and CD14 enable lipid A of LPS to be recognized by the TLR4-MD2 receptor complex. The intracellular domain of the TLR4/LPS complex stimulates MyD88-dependent/independent and TRIF-dependent pathways, which in turn activate NF-B and IRF3, leading to subsequent production of pro-inflammatory mediators. LPS has been demonstrated to ...
Source: Journal of Leukocyte Biology - April 28, 2022 Category: Hematology Authors: Austin W Kerr Philip A Efron Shawn D Larson Jaimar C Rincon Source Type: research

T-Cell Activation and LPS: A Dangerous Duo for Organ Dysfunction
J Leukoc Biol. 2022 Apr 28. doi: 10.1002/JLB.3CE0122-019R. Online ahead of print.ABSTRACTLipopolysaccharide (LPS), one of the main components of cell membranes in gram-negative bacteria, is commonly used to promote inflammation-induced organ dysfunction. In the TLR4/LPS pathway, LPS binding protein and CD14 enable lipid A of LPS to be recognized by the TLR4-MD2 receptor complex. The intracellular domain of the TLR4/LPS complex stimulates MyD88-dependent/independent and TRIF-dependent pathways, which in turn activate NF-B and IRF3, leading to subsequent production of pro-inflammatory mediators. LPS has been demonstrated to ...
Source: Journal of Leukocyte Biology - April 28, 2022 Category: Hematology Authors: Austin W Kerr Philip A Efron Shawn D Larson Jaimar C Rincon Source Type: research

T-Cell Activation and LPS: A Dangerous Duo for Organ Dysfunction
J Leukoc Biol. 2022 Apr 28. doi: 10.1002/JLB.3CE0122-019R. Online ahead of print.ABSTRACTLipopolysaccharide (LPS), one of the main components of cell membranes in gram-negative bacteria, is commonly used to promote inflammation-induced organ dysfunction. In the TLR4/LPS pathway, LPS binding protein and CD14 enable lipid A of LPS to be recognized by the TLR4-MD2 receptor complex. The intracellular domain of the TLR4/LPS complex stimulates MyD88-dependent/independent and TRIF-dependent pathways, which in turn activate NF-B and IRF3, leading to subsequent production of pro-inflammatory mediators. LPS has been demonstrated to ...
Source: Journal of Leukocyte Biology - April 28, 2022 Category: Hematology Authors: Austin W Kerr Philip A Efron Shawn D Larson Jaimar C Rincon Source Type: research