Whole blood viscosity is an independent early predictor for metabolic syndrome and its components in men: A prospective cohort study in Northern Chinese population.
Abstract The association between whole blood viscosity (WBV) and metabolic syndrome (MetS) is still scarcely investigated in the population-based prospective cohort. We aim to explore the longitudinal effect of WBV on MetS, and to verify whether WBV measures can be used as early predictors for MetS. The longitudinal cohort consisted of 3,508 adults (2,350 males and 1,158 females) who visited the health check-up system twice. WBV were measured at four shear rate (200, 50, 10 and 1 s-1), and their values were classified into quartiles. Multivariate Cox models were used to estimate the adjusted hazard ratios (HRs) an...
Source: Clinical Hemorheology and Microcirculation - January 6, 2020 Category: Hematology Authors: Zhang G, Zhang T, Sun X, Tang F, Lin H, Liu Y, Zhang C, Xue F Tags: Clin Hemorheol Microcirc Source Type: research

In vitro endothelial hyperpermeability occurs early following traumatic hemorrhagic shock.
Abstract BACKGROUND: Endothelial hyperpermeability is suggested to play a role in the development of microcirculatory perfusion disturbances and organ failure following hemorrhagic shock, but evidence is limited. OBJECTIVE: To study the effect of plasma from traumatic hemorrhagic shock patients on in vitro endothelial barrier function. METHODS: Plasma from traumatic hemorrhagic shock patients was obtained at the emergency department (ED), the intensive care unit (ICU), 24 h after ICU admission and from controls (n = 8). Sublingual microcirculatory perfusion was measured using incident dark field vi...
Source: Clinical Hemorheology and Microcirculation - January 6, 2020 Category: Hematology Authors: van Leeuwen ALI, Naumann DN, Dekker NAM, Hordijk PL, Hutchings SD, Boer C, van den Brom CE Tags: Clin Hemorheol Microcirc Source Type: research

Non-invasive evaluation of macro- and microhemodynamic changes during induction of general anesthesia - A prospective observational single-blinded trial.
Abstract BACKGROUND: Hypotension and bradycardia are known side effects of general anesthesia, while little is known about further macro- and microhemodynamic changes during induction. Intriguing is furthermore, why some patients require no vasopressor medication to uphold mean arterial pressure, while others need vasopressor support. OBJECTIVE: Determination of macro- and microhemodynamic changes during induction of general anesthesia. METHODS: We enrolled 150 female adults scheduled for gynaecological surgery into this prospective observational, single-blinded trial. Besides routinely measuring heart r...
Source: Clinical Hemorheology and Microcirculation - January 6, 2020 Category: Hematology Authors: Brettner F, Heitzer M, Thiele F, Hulde N, Nussbaum C, Achatz S, Jacob M, Becker BF, Conzen P, Kilger E, Chappell D Tags: Clin Hemorheol Microcirc Source Type: research

An explorative study of polymers for 3D printing of bioanalytical test systems.
CONCLUSIONS: Autofluorescence was not a disadvantage per se but can also be used as a reference signal in assays. The rapid development of individual protocols for sample processing and analysis required the availability of a material with consistent quality over time. The use of commercial standard materials did not seem to fulfill this requirement. PMID: 31929149 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - January 6, 2020 Category: Hematology Authors: Jurischka C, Dinter F, Efimova A, Weiss R, Schiebel J, Schulz C, Fayziev B, Schierack P, Fischer T, Rödiger S Tags: Clin Hemorheol Microcirc Source Type: research

Comparison of transcutaneous oximetry with symptoms and arteriography in thoracic outlet syndrome.
Abstract BACKGROUND: Non-invasive tests are still required to improve the holistic diagnostic approach of thoracic outlet syndrome (TOS). OBJECTIVES: We aimed to analyze the diagnostic accuracy of the decrease from rest oxygen pressure (DROP) index of transcutaneous oximetry (TcpO2) in TOS. METHODS: Seventy-six patients and 40 asymptomatic volunteers (Controls) were enrolled. In TOS-suspected patients, the arteriograms were investigated for the presence of≥75% stenosis. The area under receiver operating characteristics curve (AUC) analysis tested the ability of forearm TcpO2 during provocative maneuve...
Source: Clinical Hemorheology and Microcirculation - January 6, 2020 Category: Hematology Authors: Abraham P, Hersant J, Ramondou P, Thouveny F, Feuilloy M, Picquet J, Henni S Tags: Clin Hemorheol Microcirc Source Type: research

Performance evaluation of the ZL 6000i cone-plate rotational viscometer.
Abstract BACKGROUND: Elevated whole blood viscosity (WBV) is associated with increasing blood flow resistance in the microcirculation and is used to predict the occurrence and outcome of cardiovascular diseases. OBJECTIVE: We evaluated the analytical performance of the ZL 6000i (Zonci Technology, Beijing, China), new fully automated cone-plate rotational type viscometer. METHODS: We collected blood samples from 287 adults to establish a reference range. We evaluated total precision for 20 days using quality control (QC) samples and within-run precision was evaluated by performing 50 consecutive measureme...
Source: Clinical Hemorheology and Microcirculation - January 4, 2020 Category: Hematology Authors: Lee J, Oh SH, Kim HR Tags: Clin Hemorheol Microcirc Source Type: research

The slow releasing hydrogen sulfide donor GYY4137 reduces neointima formation upon FeCl3 injury of the carotid artery in  mice.
CONCLUSIONS: Summarizing, single treatment with the slow releasing hydrogen sulfide donor GYY reduced the extent of the newly formed neointima by affecting the cellular proliferation at the site of vascular injury. PMID: 31929150 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - January 4, 2020 Category: Hematology Authors: Grambow E, Klee G, Klar E, Vollmar B Tags: Clin Hemorheol Microcirc Source Type: research

In vivo biocompatibility study of degradable homo- versus multiblock copolymers and their (micro)structure compared to an established biomaterial.
l;der C Abstract Copolyetheresterurethane (PDC) is a biodegradable, shape-memory biomaterial, which has been shown to be of low toxicity and pro-angiogenic in vitro. In the present study we examined the in vivo compatibility of PDC as a compression molded film and as electrospun scaffolds and its well established constituent, the homopolymer poly(p-dioxanone) (PPDO), which were compared with the clinically used poly[(vinylidene fluoride)-co-hexafluoropropene] (PVDF) as reference material. The materials were implanted in the subcutaneous tissue of mice and the host responses were analyzed histologically 7 and 28 da...
Source: Clinical Hemorheology and Microcirculation - January 4, 2020 Category: Hematology Authors: Haase T, Klopfleisch R, Krost A, Sauter T, Kratz K, Peter J, Jung F, Lendlein A, Zohlnhöfer D, Rüder C Tags: Clin Hemorheol Microcirc Source Type: research

Vascular pattern and diagnostic accuracy of contrast-enhanced ultrasound (CEUS) in spleen alterations.
CONCLUSION: CEUS may provide additional information by visualization of dynamic contrast enhancement pattern to differentiate benign and malignant lesions. Nevertheless, established criteria for malignancy (early enhancement or washout) in FSL should be considered with caution since they are also found in benign lesions. PMID: 31929153 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - January 4, 2020 Category: Hematology Authors: Lerchbaumer MH, Kleemann T, Jung EM, Nagel S, Hamm B, Fischer T Tags: Clin Hemorheol Microcirc Source Type: research

Comparisons of ACR TI-RADS, ATA  guidelines, Kwak TI-RADS, and KTA/KSThR guidelines in malignancy risk stratification of thyroid nodules.
Comparisons of ACR TI-RADS, ATA guidelines, Kwak TI-RADS, and KTA/KSThR guidelines in malignancy risk stratification of thyroid nodules. Clin Hemorheol Microcirc. 2020 Jan 04;: Authors: Zhang WB, Xu HX, Zhang YF, Guo LH, Xu SH, Zhao CK, Liu BJ Abstract OBJECTIVE: To compare the diagnostic performance and the unnecessary biopsy rates for recommending fine needle aspiration (FNA) of Thyroid Imaging Reporting and Data Systems proposed by American College of Radiology (ACR TI-RADS), American Thyroid Association (ATA) guidelines, TI-RADS proposed by Kwak (Kwak TI-RADS), and Korean Thyroid As...
Source: Clinical Hemorheology and Microcirculation - January 4, 2020 Category: Hematology Authors: Zhang WB, Xu HX, Zhang YF, Guo LH, Xu SH, Zhao CK, Liu BJ Tags: Clin Hemorheol Microcirc Source Type: research

Microcirculation-guided protection strategy in hemodynamic treatment.
Abstract Microcirculatory shock is a condition defined by the presence of tissue hypoperfusion despite the normalization of systemic and regional blood flow. Currently, more evidence shows that intrinsic septic shock is microcirculatory shock, which results in septic shock that is difficult to resuscitate. At present, treatments are aimed at recovering macro-circulation functions and include fluid resuscitation, vasoactive drugs, positive inotropic drugs, de-obstruction, and even mechanical assistance to improve oxygen delivery. However, the application of these treatments to more accurately improve microcirculati...
Source: Clinical Hemorheology and Microcirculation - January 3, 2020 Category: Hematology Authors: Pan P, Su L, Liu D, Wang X Tags: Clin Hemorheol Microcirc Source Type: research

Perioperative Ulinastatin helps preserve endothelial glycocalyx layer in periampullary carcinoma patients undergoing traditional Whipple procedure.
CONCLUSIONS: We found global inflammation reaction and EGL degradation during TWP. Perioperative UTI treatment can attenuate this EGL shedding and might alleviate plasma albumin leakage. PMID: 31903986 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - January 2, 2020 Category: Hematology Authors: Wang JW, Wu AS, Yue Y, Wu Y Tags: Clin Hemorheol Microcirc Source Type: research

Hemorheology and oxidative stress in patients with differentiated thyroid cancer following I-131 ablation/metastasis treatment.
Abstract BACKGROUND: Although radioiodine theraphy (RAIT) is thought to affect blood cells and oxidative stress, hemorheological alterations following dose-dependent RAIT remains unknown. OBJECTIVE: The aim of this study was to determine the effects of RAIT on hemorheological and oxidative stress parameters in patients with differentiated thyroid cancers (DTC). METHODS: Totally 31 DTC patients (mean age 46.32±11.15 years) and 26 healthy controls (mean age 50.50±6.22 years) were included. Venous blood samples were collected from each patient before and after treatment (7th day, 1th month and...
Source: Clinical Hemorheology and Microcirculation - December 26, 2019 Category: Hematology Authors: Sengoz T, Kilic-Toprak E, Yaylali O, Kilic-Erkek O, Ozdemir Y, Oymak B, Senol H, Yuksel D, Kucukatay V, Bor-Kucukatay M Tags: Clin Hemorheol Microcirc Source Type: research

Angiopoietin-1: Can be produced by endothelial cells and act in an autocrine agonistic manner?
CONCLUSIONS: Endothelial cells can also produce Ang1. In addition, endogenous Ang1 may be an autocrine agonistic regulator, participating in endothelial cells angiogenesis process. PMID: 31884457 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - December 26, 2019 Category: Hematology Authors: Pan L, Liu Z, Chen Y, Cheng B, Yang B Tags: Clin Hemorheol Microcirc Source Type: research

Substrate-enzyme affinity-based surface modification strategy for endothelial cell-specific binding under shear stress.
g F Abstract Establishing an endothelial cell (EC) monolayer on top of the blood contacting surface of grafts is considered to be a promising approach for creating a hemocompatible surface. Here we utilized the high affinity interactions between the EC plasma membrane expressed enzyme called endothelin converting enzyme-1 (ECE-1) and its corresponding substrate big Endothelin-1 (bigET-1) to engineer an EC-specific binding surface. Since enzymatic cleavage of substrates require physical interaction between the enzyme and its corresponding substrate, it was hypothesized that a surface with chemically immobilized syn...
Source: Clinical Hemorheology and Microcirculation - December 26, 2019 Category: Hematology Authors: Lee S, Ganesan R, Krüger-Genge A, Kratz K, Franke RP, Lendlein A, Jung F Tags: Clin Hemorheol Microcirc Source Type: research

Microrheology, microcirculation and structural compensatory mechanisms of a chronic kidney disease rat model. A preliminary study.
Abstract BACKGROUND: Chronic kidney disease (CKD) models are known to study pathophysiology and various treatment methods. Renal dysfunction could influence erythrocytes through several pathways. However, hemorheological and microcirculatory relation of CKD models are not completely studied yet. OBJECTIVE: To evaluate erythrocyte micro-rheology, microcirculatory and structural compensatory mechanisms in a rat model of CKD. METHODS: Female Sprague-Dawley rats were subjected to nephrectomy group (NG, n = 6) or sham-operated group (SG, n = 6). NG rats were subjected to 5/6 nephrectomy in two stages....
Source: Clinical Hemorheology and Microcirculation - December 26, 2019 Category: Hematology Authors: Ghanem S, Lesznyak T, Fazekas L, Tanczos B, Barath B, Nasser M, Horvath L, Bidiga L, Szabo B, Deak A, Peto K, Nemeth N Tags: Clin Hemorheol Microcirc Source Type: research

The role of preoperative ultrasound, contrast-enhanced ultrasound, and 99mTc-MIBI scanning with single-photon emission computed tomography/X-ray computed tomography localization in refractory secondary hyperparathyroidism.
Abstract OBJECTIVE: The aim of our study was to evaluate the role of preoperative US, CEUS, and 99mTc-MIBI scanning with SPECT/CT in localizing diseased parathyroid glands in cases of refractory secondary hyperparathyroidism (SHPT). MATERIAL AND METHODS: Using pathological results as the gold standard, we compared the operative findings with the preoperative localization of each modality in 73 nodules and evaluated the accuracy, and sensitivity of each modality and combinations of the four modalities. RESULTS: The sensitivity of US, CEUS, 99mTc-MIBI and SPECT/CT was 98.59%, 94.37%, 50.70% and 78.87%, res...
Source: Clinical Hemorheology and Microcirculation - December 19, 2019 Category: Hematology Authors: Li X, Li J, Li Y, Wang H, Yang J, Mou S, Zhou M, Jiang C, Ning C Tags: Clin Hemorheol Microcirc Source Type: research

Incorporation of contrast-enhanced ultrasound in the differential diagnosis for breast lesions with inconsistent results on mammography and conventional ultrasound.
Abstract OBJECTIVE: To identify the efficacy of contrast-enhanced ultrasound (CEUS) in re-evaluating masses with inconsistent Breast Imaging Reporting and Data System (BI-RADS) on mammography (MG) and conventional ultrasound (US). MATERIALS AND METHODS: A total of 637 breast lesions were evaluated with MG, US, and CEUS within 6 months and assessed as BI-RADS MG and US. CEUS was used as an additional screening to rerate BI-RADS US according to a five-point system. Lesions were divided into consistent or inconsistent group on the basis of BI-RADS MG and US assessment. The performance of MG, US, and CEUS in the ...
Source: Clinical Hemorheology and Microcirculation - December 19, 2019 Category: Hematology Authors: Shao SH, Li CX, Yao MH, Li G, Li X, Wu R Tags: Clin Hemorheol Microcirc Source Type: research

Research progress of CA125 and BDNF in serum of patients with acute myocardial infarction for predicting acute heart failure.
Abstract BACKGROUND: At present, the treatment for acute myocardial infarction has achieved great progress. Reperfusion therapy in the short term can effectively reduce recurrence rates and mortality in patients with acute myocardial infarction. According to a report of a large national registry, the mortality of patients with acute coronary syndrome combined with acute heart failure is 10 times of that of patients without heart failure, and the mortality in nearly 10 years has no significant change. Therefore, people are constantly exploring indicators for acute heart failure prognosis to improve a patient's prog...
Source: Clinical Hemorheology and Microcirculation - December 19, 2019 Category: Hematology Authors: Wu HB, Shao K, Wang YC, Wang XC, Liu HL, Xie YT, Du RP Tags: Clin Hemorheol Microcirc Source Type: research

Age-related morphology and function of human arterial endothelial cells1.
Jung F Abstract Endothelialization of cardiovascular implants is regarded as a promising strategy for long-term compatibility. While umbilical vein endothelial cells are typically applied in research, human arterial endothelial cells (HAEC) from elderly donors would be the obvious source for autologous cellularization strategies.In our approach, HAEC from 16 donors of varying age (16-63 years) were divided into two groups (30 years) and analyzed regarding morphology, viability, proliferation, function and senescence status.No age-related differences were found regarding morphology, viability, density, prosta...
Source: Clinical Hemorheology and Microcirculation - December 13, 2019 Category: Hematology Authors: Lau S, Rangarajan R, Krüger-Genge A, Braune S, Küpper JH, Lendlein A, Jung F Tags: Clin Hemorheol Microcirc Source Type: research

Interaction between extracellular cancer matrix and stromal breast cells1.
DISCUSSION: Our results clearly demonstrate that the tECM is able to shift the gene expression pattern of murine mammary epithelial cells towards that of carcinoma, indicating a role in breast cancer initiation. These data underlines that the acellular component of the tumor (ECM) can lead to a transformation of mammary gland tissue cells. These data show for the first time that the interaction of normal breast tissue cells with tumor ECM leads to an exchange of information and a consecutive overexpression of tumor-specific genes. PMID: 31796667 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - November 23, 2019 Category: Hematology Authors: Gehmert S, Lehoczky G, Loibl M, Jung F, Prantl L, Gehmert S Tags: Clin Hemorheol Microcirc Source Type: research

Pododermal angioarchitecture in the equine hoof wall: A light and scanning electron microscopic study of the wall proper1.
CONCLUSIONS: The vasculature of the hoof wall displays specific angio-adaptations to high pressure and tensile load. PMID: 31771048 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - November 16, 2019 Category: Hematology Authors: Sievers H, Hiebl B, Hünigen H, Hirschberg RM Tags: Clin Hemorheol Microcirc Source Type: research

The role of arginase in the microcirculation in cardiovascular disease1.
Abstract In the microcirculation, the exchange of nutrients, water, gas, hormones, and waste takes place, and it is divided into the three main sections arterioles, capillaries, and venules. Disturbances in the microcirculation can be measured using surrogate parameters or be visualized either indirectly or directly.Arginase is a manganese metalloenzyme hydrolyzing L-arginine to urea and L-ornithine. It is located in different cell types, including vascular cells, but also in circulating cells such as red blood cells. A variety of pro-inflammatory factors, as well as interleukins, stimulate increased arginase expr...
Source: Clinical Hemorheology and Microcirculation - November 14, 2019 Category: Hematology Authors: Wernly B, Pernow J, Kelm M, Jung C Tags: Clin Hemorheol Microcirc Source Type: research

Prospective evaluation of 4-D contrast-enhanced-ultrasound (CEUS) imaging in bladder tumors1.
Abstract PURPOSE: The evaluation of the potential clinical benefit of four-dimensional ultrasound (4D-US) in the assessment of bladder cancer (BC). MATERIAL AND METHODS: 20 patients with indication for cystoscopy for suspicion of bladder cancer were prospectively included in this study. All patients underwent two-dimensional ultrasound (2D-US), contrast enhanced ultrasound (CEUS) and real-time four-dimensional ultrasound (4D-US). All acquisitions were compared to each other in regard to image quality. This assessment was done using a 6 point scale (1 = best). All patients underwent subsequently cystoscopy...
Source: Clinical Hemorheology and Microcirculation - November 13, 2019 Category: Hematology Authors: Jokisch F, Buchner A, Schulz GB, Grimm T, Weinhold P, Pfitzinger PL, Chaloupka M, Stief CG, Schlenker B, Clevert DA Tags: Clin Hemorheol Microcirc Source Type: research

Advantage and use of S-patch cardio solution in competitive motor sports1.
CONCLUSION: Professional kart racing drivers had sinustachycardia with heart rates up to 193 beats min-1 during races. This is most likely attributed to a considerably high emotional and physiological stress affecting the cardiovascular system. Episodes of tachycardia positively correlated with mean speed. In the warm-up lap the heart rate was significantly lower in comparison to the race, suggesting that faster driving speed would induce greater cardiovascular stress to professional drivers during actual races. The experimental results showed that the proposed S-patch system provided a good ECG signal quality with accurat...
Source: Clinical Hemorheology and Microcirculation - November 13, 2019 Category: Hematology Authors: Puhr-Westerheide D, Kostbade T, Clevert DA Tags: Clin Hemorheol Microcirc Source Type: research

Coaxial electrospinning of PEEU/gelatin to fiber meshes with enhanced mesenchymal stem cell attachment and proliferation1.
In this study, a thermoplastic, degradable polyesteretherurethane, consisting of poly(p-dioxanone) (PPDO) and poly(ɛ-caprolactone) (PCL) segments with different PPDO to PCL weight ratios, were processed into fiber meshes by co-axial electrospinning with gelatin. The prepared PEEU fibers have a diameter of 1.3±0.5 μm and an elastic modulus of around 5.1±1.0 MPa as measured by tensile testing in a dry state at 37°C, while the PEEU/Gelatin core-shell fibers with a gelatin content of 12±6 wt% and a diameter of 1.5±0.5 μm possess an elastic modulus of 15.0±1.1 MPa in a dry state...
Source: Clinical Hemorheology and Microcirculation - November 13, 2019 Category: Hematology Authors: Tung WT, Zou J, Sun X, Wang W, Gould OEC, Kratz K, Ma N, Lendlein A Tags: Clin Hemorheol Microcirc Source Type: research

Intra-individual comparison of human nasal chondrocytes and debrided knee chondrocytes: Relevance for engineering autologous cartilage grafts1.
CONCLUSIONS: dKC exhibit a reproducibly poor capacity to engineer cartilage grafts. Our in vitro data suggest that NC would be a better suitable cell source for the generation of autologous cartilage grafts. PMID: 31743993 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - November 13, 2019 Category: Hematology Authors: Lehoczky G, Wolf F, Mumme M, Gehmert S, Miot S, Haug M, Jakob M, Martin I, Barbero A Tags: Clin Hemorheol Microcirc Source Type: research

Validation of a novel ultrasound Doppler monitoring device (earlybird) for detection of microvascular circulatory changes.
CONCLUSION: Earlybird records vasoconstrictions in healthy subjects as well as LDF and pulsed Doppler. PMID: 31743988 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - November 11, 2019 Category: Hematology Authors: Mulder Pettersen E, Avdal J, Hisdal J, Torp H, Seternes A Tags: Clin Hemorheol Microcirc Source Type: research

Long-term study analysis of contrast-enhanced ultrasound in the diagnosis of focal nodular hyperplasia.
CONCLUSION: CEUS is a safe and feasible approach that assess the diagnosis of focal nodular hyperplasia equally to MRI. The focal lesion enhancement can be depicted in real-time in the arterial, venous and late phase facilitating the prompt diagnosis. PMID: 31743989 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - November 11, 2019 Category: Hematology Authors: Negrão de Figueiredo G, Mueller-Peltzer K, Schwarze V, Marschner C, Zhang L, Rübenthaler J, Siepmann T, Illigens BW, Clevert DA Tags: Clin Hemorheol Microcirc Source Type: research

Effects of dexmedetomidine on cerebral oxygen saturation and postoperative cognitive function in elderly patients undergoing minimally invasive coronary artery bypass surgery.
This study aimed to investigate the effects of dexmedetomidine on cerebral oxygen saturation [Sct(O2)] and postoperative cognitive function in elderly patients undergoing minimally invasive coronary artery bypass graft surgery. METHODS: Sixty elderly patients who received minimally invasive coronary artery bypass graft surgery were randomly equally divided into dexmedetomidine group (group D) and control group (group N). The patients in group D were pumped with 1 μg/kg dexmedetomidine for 15 min before incision, followed by continuous pumping at 0.3-0.5 μg/(kg·h) till the end of the operation. The patie...
Source: Clinical Hemorheology and Microcirculation - November 1, 2019 Category: Hematology Authors: Gao Y, Zhu X, Huang L, Teng J, Li F Tags: Clin Hemorheol Microcirc Source Type: research

Determination of frail state and association of frailty with inflammatory markers among cardiac surgery patients in a Central European patient population.
CONCLUSIONS: We first present the incidence of frailty in patients with heart surgery in a Central-European population. According to our results, inflammatory processes are likely to play a role in the development of the frail state. PMID: 31683468 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - November 1, 2019 Category: Hematology Authors: Kiss R, Farkas N, Jancso G, Kovacs K, Lenard L Tags: Clin Hemorheol Microcirc Source Type: research

Behaviour of carbonyl groups in several clinical conditions: Analysis of our survey.
sti R Abstract Protein carbonylation is a marker of oxidative protein damage, that is likely involved in the pathogenesis of several diseases. The aim of this study was to evaluate the protein carbonyl (PC) groups in different clinical conditions. It included different groups of subjects: 81 trained subjects; 23 subjects with mild essential hypertension; 31 middle-aged subjects with metabolic syndrome (MS); 106 subjects with MS not selected for age (subdivided into two subgroups, with and without diabetes mellitus); 91 obese adults subdivided in two subgroups (BMI 30-35 Kg/m2 and BMI > 35 kg/m2); 48 subject...
Source: Clinical Hemorheology and Microcirculation - November 1, 2019 Category: Hematology Authors: Caimi G, Hopps E, Montana M, Carollo C, Calandrino V, Gallà E, Canino B, Lo Presti R Tags: Clin Hemorheol Microcirc Source Type: research

Combined use of strain elastography and superb microvascular imaging with grayscale ultrasound according to the BI-RADS classification for differentiating benign from malignant solid breast masses.
Abstract OBJECTIVE: To evaluate the combined use of strain elastography (SE) and superb microvascular imaging (SMI) with grayscale ultrasound (US) according to the Breast Imaging Reporting and Data System (BI-RADS) classification for differentiating benign from malignant breast masses. METHODS: In total, 166 patients with 177 breast masses categorized as BI-RADS 3-5 were included in the study between April 2016 to September 2017. US, SMI and SE were performed to evaluate each mass. The following outcome measures were compared between US and the combinations of US, SMI, and SE: area under the receiver operatin...
Source: Clinical Hemorheology and Microcirculation - November 1, 2019 Category: Hematology Authors: Liang M, Ou B, Wu J, Xiao X, Ruan J, Tian J, Xu X, Wang B, Yang H, Luo B Tags: Clin Hemorheol Microcirc Source Type: research

Elasticity of fiber meshes from multiblock copolymers influences endothelial cell behavior.
CONCLUSIONS: These results suggested that tuning the fiber meshes' elasticity might be a potential strategy for modulating of the formation or regeneration of blood vessels. PMID: 31683471 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - November 1, 2019 Category: Hematology Authors: Sun X, Tung W, Zou J, Wang W, Kratz K, Ma N, Lendlein A Tags: Clin Hemorheol Microcirc Source Type: research

Chronic intermittent hypoxia vs chronic continuous hypoxia: Effects on vascular endothelial function and myocardial contractility.
Abstract BACKGROUND AND AIM: Both chronic intermittent hypoxia (CIH) and chronic continuous hypoxia (CCH) are risk factors for cardiovascular disease, which are associated with cardiac systolic function and associated with dysfunction of endothelia and coagulation-fibrinolysis system in the vasculature. However, the different effects of these two hypoxic models are not fully understood. In our study, we systemically compared the effects of CIH and CCH on cardiac function and related factor levels in serum using rat model. METHODS: Forty-five male Sprague-Dawley rats were randomly divided into the normoxia con...
Source: Clinical Hemorheology and Microcirculation - November 1, 2019 Category: Hematology Authors: Zhu J, Kang J, Li X, Wang M, Shang M, Luo Y, Xiong M, Hu K Tags: Clin Hemorheol Microcirc Source Type: research

V Flow technology in measurement of wall shear stress of common carotid arteries in healthy adults: Feasibility and normal values.
Abstract OBJECTIVE: To evaluate the feasibility of vector flow imaging technique (V Flow) in measurement of wall shear stress (WSS) of common carotid arteries (CCA) in healthy adults and to provide the normal WSS values assessed by V Flow. METHODS & MATERIALS: This prospective study was approved by the Ethics Committee of our University. Eighty healthy adult volunteers were included (mean age 43.3 y, 47 females, 33 males). The volunteers were classified into three groups according to their age: group I (age 20 - 39 y), group II (age 40 - 59 y) and group III (age 60 - 80 y). Mindray Resona 8 ultrasound mac...
Source: Clinical Hemorheology and Microcirculation - November 1, 2019 Category: Hematology Authors: Qiu Y, Yang D, Zhang Q, Chen K, Dong Y, Wang W Tags: Clin Hemorheol Microcirc Source Type: research

Value of conventional ultrasound, ultrasound elasticity imaging, and acoustic radiation force impulse elastography for prediction of malignancy in breast lesions.
Abstract OBJECTIVE: To evaluate the efficacies of conventional ultrasound (US), US elasticity imaging (EI), and acoustic radiation force impulse (ARFI) elastography in breast malignancy diagnosis. METHODS: We included 315 women (mean age, 44 years; range, 18-81 years) with 336 pathologically proven breast lesions in this retrospective study. All lesions underwent conventional US, EI, and ARFI (including virtual touch tissue imaging [VTI], virtual touch tissue quantification [VTQ], and virtual touch tissue imaging and quantification [VTIQ]) elastography. Multivariate logistic regression analysis was performed ...
Source: Clinical Hemorheology and Microcirculation - October 30, 2019 Category: Hematology Authors: Zhang S, Wan J, Wu R, Fang Y Tags: Clin Hemorheol Microcirc Source Type: research

The value of conventional sonography and ultrasound elastography in decision-making for thyroid nodules in different categories of the Bethesda system for reporting thyroid cytopathology.
CONCLUSIONS: Conventional US is complementary to FNA for providing additional hints especially in categories I-IV for further clinical managements, while RTE failed to provide useful diagnostic information in general. PMID: 31683465 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - October 30, 2019 Category: Hematology Authors: Wu Q, Li Y, Liu Y, Shen J, Wang Y, Yi X, Hu B Tags: Clin Hemorheol Microcirc Source Type: research

Evaluation of endothelial glycocalyx in healthy volunteers - An observational study.
CONCLUSION: This study provides a comparison for cohorts of patients with a particular disease where the EG is presumably damaged. Our findings do not entirely comply with already published data in healthy individuals. PMID: 31683466 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - October 30, 2019 Category: Hematology Authors: Astapenko D, Ticha A, Tomasova A, Hyspler R, Zadak Z, Lehmann C, Cerny V Tags: Clin Hemorheol Microcirc Source Type: research

Partially cystic thyroid nodules on ultrasound: The associated factors for malignancy.
CONCLUSIONS: Understanding the ultrasound characteristics of malignant PCTNs is important to make a precise diagnosis of thyroid nodules. PMID: 31658050 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - October 19, 2019 Category: Hematology Authors: Shi YZ, Jin Y, Zheng L Tags: Clin Hemorheol Microcirc Source Type: research

Erythrocyte deformability and aggregability in patients undergoing colon cancer surgery and effects of two infusions with omega-3 fatty acids.
CONCLUSION: This study confirms rapid changes in erythrocyte membrane phospholipid composition after administration of intravenous n-3 PUFAs. Erythrocyte deformability parameters were not affected but erythrocyte aggregability was decreased in the n-3 PUFA group. Further investigation is necessary to gain more insights in the effects of n-3 PUFA and the postoperative inflammatory response on erythrocyte function. PMID: 31658051 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - October 19, 2019 Category: Hematology Authors: Bakker N, Schoorl M, Stoutjesdijk E, Houdijk APJ Tags: Clin Hemorheol Microcirc Source Type: research

Value of contrast-enhanced ultrasound (CEUS) in Focal Liver Lesions (FLL) with inconclusive findings on cross-sectional imaging.
CONCLUSION: CEUS correctly distinguished malignant from benign FLL in cases with inconclusive cross-sectional imaging findings and achieved high levels of diagnostic accuracy. CEUS has added diagnostic value especially in small lesions ≤1 cm while specificity remains limited in larger lesions. PMID: 31658052 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - October 19, 2019 Category: Hematology Authors: Auer TA, Fischer T, Garcia SRM, Penzkofer T, Jung EM, Hamm B, Lerchbaumer MH Tags: Clin Hemorheol Microcirc Source Type: research

The peripapillary retinal capillary density is highly correlated with its nerve fibre layer in normal population.
Abstract PURPOSE: To explore the peripapillary capillary density distribution and its correlation with nerve fibre layer in superficial and deep retinal layers of healthy Chinese. METHODS: Images of superficial and deep retinal capillary networks were obtained by optical coherence tomography angiography (OCTA) using a CIRRUS TM HD-OCT Model 5000 system and analyzed by Image-Pro Plus (Medical Cybernetics, Version 6.0). Peripapillary capillary density was defined as the mean optical density of the annular region between two concentric circles of 3.085 mm and 3.835 mm diameter. Parafoveal capillary density w...
Source: Clinical Hemorheology and Microcirculation - October 14, 2019 Category: Hematology Authors: Ding X, Lu L, Yang J, Chen Y, Jin M Tags: Clin Hemorheol Microcirc Source Type: research

Timing of clopidogrel loading dose on peripheral blood endothelial progenitor cells, SDF-1 α and neointimal hyperplasia in carotid stenting.
Timing of clopidogrel loading dose on peripheral blood endothelial progenitor cells, SDF-1α and neointimal hyperplasia in carotid stenting. Clin Hemorheol Microcirc. 2019 Sep 29;: Authors: Di Stolfo G Abstract BACKGROUND: Carotid stenting stimulates intimal proliferation through platelet and stem cell activation. OBJECTIVE: The aim of this study is to evaluate whether the administration before or after carotid stenting of clopidogrel loading dose may play a role on circulating endothelial progenitor cells, stromal cell-derived factor-1α (SDF-1α) and neointimal hyperplasia. ...
Source: Clinical Hemorheology and Microcirculation - October 16, 2018 Category: Hematology Authors: Di Stolfo G Tags: Clin Hemorheol Microcirc Source Type: research

Remote ischemic preconditioning of the heart: Combining lower limb ischemia and electronic stimulation of the gastrocnemius muscle.
CONCLUSION: Our results again confirm the feasibility of remote ischemic preconditioning in patients undergoing coronary angioplasty. According to our results ischemia combined with electronic skeletal muscle stimulation was not superior to conventional RIPC cycles (skeletal muscle ischemia alone). PMID: 30320566 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - October 9, 2018 Category: Hematology Authors: Reinthaler M, Jung F, Empen K Tags: Clin Hemorheol Microcirc Source Type: research

Early red blood cell abnormalities as a clinical variable in sepsis diagnosis.
CONCLUSIONS: RBC aggregation appears to be an early indicator of clinical deterioration in sepsis and may represent a diagnostic indicator in sepsis. PMID: 30320561 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - October 4, 2018 Category: Hematology Authors: Ko E, Youn JM, Park HS, Song M, Koh KH, Lim CH Tags: Clin Hemorheol Microcirc Source Type: research

Hemorheological alterations following an acute bout of nordic hamstring exercise in active male participants1.
CONCLUSIONS: Our results suggest that, increased RBC aggregation following an acute bout of NHE may result in increased plasma skimming and thus ease the flow of blood. PMID: 30320558 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - September 29, 2018 Category: Hematology Authors: Unver F, Kilic-Toprak E, Kilic-Erkek O, Korkmaz H, Yasin O, Oymak B, Oskay A, Bor-Kucukatay M Tags: Clin Hemorheol Microcirc Source Type: research

Long-term radiation exposure in patients undergoing EVAR: Reflecting clinical day-to-day practice to assess realistic radiation burden.
Abstract Endovascular repair of aortic aneurysms (EVAR) has become an established treatment option currently applied in an increasing numbers of patients with aortic aneurysms. Advantages include reduced surgical trauma, procedural time, intensive care unit and hospital lengths of stay, blood loss as well as morbidity and mortality.The optimal imaging modalities in EVAR follow-up as well as the appropriate intervals between these follow-ups remain subject of controversial discussion. Objective of this study was the evaluation of the realistic radiation exposure and risk estimate postop EVAR treatment.Of the follow...
Source: Clinical Hemorheology and Microcirculation - September 19, 2018 Category: Hematology Authors: Kalender G, Milan L, Stock UA, Endisch A, Kornberger A Tags: Clin Hemorheol Microcirc Source Type: research

Intraoperative US and contrast-enhanced intraoperative US during hepatic resection for patients with hepatocellular carcinoma in liver cirrhosis1.
Abstract PURPOSE: To retrospectively evaluate the role of intraoperative ultrasonography (IOUS) and contrast-enhanced IOUS (CE-IOUS) for the patients with hepatocellular carcinoma (HCC) undergoing hepatic resection (HR). METHODS: Twenty-one consecutive patients who had undergone HR for HCC were included in this study. The patients were subject to preoperative imaging modalities including preoperative ultrasonography (Pre-US) and preoperative contrast-enhanced ultrasonography (Pre-CEUS). All the patients then underwent intraoperative ultrasonography (IOUS) and contrast-enhanced intraoperative ultrasonography (...
Source: Clinical Hemorheology and Microcirculation - September 19, 2018 Category: Hematology Authors: Gong NM Tags: Clin Hemorheol Microcirc Source Type: research

Special Section: The ESCHM "1st Hemorheology Days", 19 - 21 July 2017, Puchberg/Schneeberg, Austria.
Special Section: The ESCHM "1st Hemorheology Days", 19 - 21 July 2017, Puchberg/Schneeberg, Austria. Clin Hemorheol Microcirc. 2018;69(4):489 Authors: PMID: 30124443 [PubMed - in process] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - August 22, 2018 Category: Hematology Tags: Clin Hemorheol Microcirc Source Type: research