The diagnostic performance of shear wave velocity ratio for the differential diagnosis of benign and malignant breast lesions: Compared with VTQ, and mammography.
CONCLUSION: The SWV ratio can improve the sensitivity without sacrificing diagnostic specificity in the process of breast cancer diagnostic, provide a better diagnostic performance, and avoid unnecessary biopsy or surgery. PMID: 32924988 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - September 10, 2020 Category: Hematology Authors: Zhong LC, Yang T, Gu LP, Ma F Tags: Clin Hemorheol Microcirc Source Type: research

Conventional and contrast-enhanced ultrasound features in sclerosing adenosis and correlation with pathology.
Abstract OBJECTIVES: To evaluate the efficacy of conventional ultrasound (US) and contrast-enhanced ultrasound (CEUS) in differential diagnosis of sclerosing adenosis (SA) from malignance and investigate the correlated features with pathology. METHODS: We retrospectively enrolled 103 pathologically confirmed SA. All lesions were evaluated with conventional US while 31 lesions with CEUS. Lesions were divided into SA with or without benign lesions (Group 1, n = 81) and SA with malignancy (Group 2, n = 22). Performance of two methods were analyzed. The ultrasonographic characteristics were compared betwe...
Source: Clinical Hemorheology and Microcirculation - September 10, 2020 Category: Hematology Authors: Shao S, Yao M, Li X, Li C, Chen J, Li G, Jia C, Wu R Tags: Clin Hemorheol Microcirc Source Type: research

The effect of diabetic ketoacidosis (DKA) and its treatment on clot microstructure: Are  they thrombogenic?
The effect of diabetic ketoacidosis (DKA) and its treatment on clot microstructure: Are they thrombogenic? Clin Hemorheol Microcirc. 2020 Sep 10;: Authors: Pillai S, Davies G, Lawrence MJ, Whitley J, Stephens JW, Williams PR, Morris K, Evans PA Abstract BACKGROUND: Diabetic ketoacidosis (DKA) is a medical emergency with a high mortality rate and is associated with severe metabolic acidosis and dehydration. DKA patients have an increased risk of arterial and venous thromboembolism, however little is known about this metabolic derangement in the first 24 hours of admission and to assess its effect ...
Source: Clinical Hemorheology and Microcirculation - September 10, 2020 Category: Hematology Authors: Pillai S, Davies G, Lawrence MJ, Whitley J, Stephens JW, Williams PR, Morris K, Evans PA Tags: Clin Hemorheol Microcirc Source Type: research

Frequent recurrence of pregnancy-triggered congenital thrombotic thrombocytopenic purpura: A rare case report.
We report a case of a 24-year-old woman who was diagnosed as TTP during early pregnancy. A novel mutation was detected: c.3667G>T (p.E1223*). She responded well to plasma therapy during pregnancy and had a child by cesarean section at 32 weeks. TTP is still recurrent in postpartum patients. The plasma transfusion was effective, but caused a severe transfusion reaction. Cyclosporine was administered with the consent of the patient. This case showed cyclosporine-A (CSA) had a positive effect on ADAMTS13 activity. At 11-months follow-up, the patient's blood cells and LDH status were stable and no symptom was seen. Our case...
Source: Clinical Hemorheology and Microcirculation - September 10, 2020 Category: Hematology Authors: Xu J, Yu S, Zhang F Tags: Clin Hemorheol Microcirc Source Type: research

Ultrasound elastography for the detection of capsular fibrosis in breast implants: First results.
CONCLUSION: Preoperative Baker scores prior to exchange and the current Baker scores at the follow-up showed significantly lower score points three years after exchange of the implants. Ultrasound elastography seems to be an objective classification of capsular fibrosis. These first results motivate to initiate a prospective multicenter investigation. PMID: 32924990 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - September 8, 2020 Category: Hematology Authors: Jung E, Hösl V, von Fraunberg S, Jung F, Prantl L Tags: Clin Hemorheol Microcirc Source Type: research

A clinical study on the effect of open chronic total occlusion on hemodynamics of  collateral circulation donor.
This study applied pressure measurement to measure the hemodynamic changes in right coronary artery (RCA) donor vessels before and after the opening of the vessel in patients with left anterior descending chronic total occlusion (LAD-CTO) interventional therapy. METHODS: A total of 45 patients with LAD-CTO were divided into two groups of percutaneous coronary intervention (PCI) to observe the hemodynamic changes (fractional flow reserve [FFR] and instantaneous wave-free ratio [iFR]) before and after opening the chronic total occlusion (CTO), in order to provide collateral circulating donor vessels to the CTO, and obse...
Source: Clinical Hemorheology and Microcirculation - September 8, 2020 Category: Hematology Authors: Tian B, Li W, Wu Z, Gong M, Liu J Tags: Clin Hemorheol Microcirc Source Type: research

Application of ultrasound-guided biopsy and percutaneous radiofrequency ablation in  2 cases with phosphaturic mesenchymal tumor and literature review.
We report two cases with PMT who presented syndrome with progressive musculoskeletal complaints and performed ultrasound-guided biopsy and RFA. Ultrasound-guided RFA, which is a safe and effective minimally invasive treatment option, appears to be a valuable alternative to surgery for patients presenting with PMT. We are the first reported case of RFA guided by ultrasonography in the treatment of PMT. PMID: 32924995 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - September 8, 2020 Category: Hematology Authors: Xian MF, Pan KM, Zhang JC, Chen MQ, Huang H, Chen LD, Wang W Tags: Clin Hemorheol Microcirc Source Type: research

Dynamic changes in platelets caused by shear stress in aortic valve stenosis.
Abstract BACKGROUND AND OBJECTIVE: Turbulent blood flow in patients with aortic valve stenosis (AS) results in morphological and functional changes in platelets and coagulation factors. The aim of this study is to determine how shear stress affects platelets and coagulation factors. METHODS: We retrospectively evaluated data from 78 patients who underwent AVR to treat AS between March 2008 and July 2017 at Kagoshima University Hospital. RESULTS: Platelet (PLT) count obviously decreased at three days after AVR, and increased above preoperative levels at the time of discharge. In contrast, platelet distrib...
Source: Clinical Hemorheology and Microcirculation - September 8, 2020 Category: Hematology Authors: Kanda H, Yamakuchi M, Mastumoto K, Mukaihara K, Shigehisa Y, Tachioka S, Okawa M, Takenouchi K, Oyama Y, Hashiguchi T, Imoto Y Tags: Clin Hemorheol Microcirc Source Type: research

Doppler ultrasonography and contrast-enhanced ultrasonography to evaluate liver allograft discard: A pilot prospective study.
CONCLUSIONS: DUS/CEUS could be applied as a promising predictive tool to screen high-risk liver donors. The prolonged SAT of hepatic artery on DUS and the decrease of liver donor in enhancement on CEUS, indicating hemodynamic changes in DBD and DCD donor livers, were risk factors of liver discarded. PMID: 32925000 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - September 8, 2020 Category: Hematology Authors: Zhang HJ, Zheng BW, Gu SJ, Wu T, Wu LL, Lian YF, Tong G, Yi SH, Ren J Tags: Clin Hemorheol Microcirc Source Type: research

Complement-mediated Extracellular Vesicle release as a measure of endothelial dysfunction and prognostic marker for COVID-19 in peripheral blood.
PMID: 32925002 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - September 8, 2020 Category: Hematology Authors: Inal J Tags: Clin Hemorheol Microcirc Source Type: research

Abnormal nailfold videocapillaroscopic findings in heart failure patients with preserved ejection fraction.
In this study; we aimed to investigate the nailfold capillaroscopic abnormalities in heart failure patients with reduced and preserved ejection fraction and compare those with control group. METHODS: Three groups of patients were recruited for the study: HFrEF group includes the patients with heart failure with reduced ejection fraction (HFrEF), HFpEF group, patients with heart failure with preserved ejection fraction (HFpEF) and control group, healthy asymptomatic individuals. Nailfold videocapillaroscopy was performed with a videodermatoscope and all nailfold images were evaluated for enlargement and hemorrhages. ...
Source: Clinical Hemorheology and Microcirculation - September 8, 2020 Category: Hematology Authors: Yüksel S, Pancar Yüksel E, Meriç M Tags: Clin Hemorheol Microcirc Source Type: research

Contrast enhanced ultrasound (CEUS) with parametric imaging and time intensity curve analysis (TIC) for evaluation of the success of prostate arterial embolization (PAE) in cases of prostate hyperplasia.
CONCLUSION: Performed by an experienced examiner CEUS with parametric imaging and TIC-analysis is highly useful to further establish prostatic artery embolization (PAE) as a successful minimal invasive treatment of benign prostatic hyperplasia. PMID: 32925006 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - September 8, 2020 Category: Hematology Authors: Jung EM, Wertheimer T, Putz FJ, Jung F, Kammerer S, Pregler B, Luerken L, Stroszczynski C, Beyer L Tags: Clin Hemorheol Microcirc Source Type: research

Contrast-enhanced ultrasound with perfusion analysis in patients with venous malformations before and after percutaneous treatment with ethanol-gel.
Abstract INTRODUCTION: Percutaneous sclerotherapy is a well-established treatment option for venous malformations (VM). A recently established sclerosing agent is ethanol-gel. Aim of this study was to identify, if contrast-enhanced ultrasound (CEUS) with an integrated perfusion analysis allows for differentiation between untreated VM, healthy tissue, and with gelified ethanol treated malformation tissue. MATERIAL AND METHODS: In this institutional review board approved prospective study symptomatic VM patients underwent CEUS at exactly the same position before and after sclerotherapy with ethanol-gel. Two exp...
Source: Clinical Hemorheology and Microcirculation - September 8, 2020 Category: Hematology Authors: Teusch VI, Wohlgemuth WA, Uller W, Piehler AP, Goessmann H, Stroszczynski C, Jung EM Tags: Clin Hemorheol Microcirc Source Type: research

3D monitoring of tumor volume in an in vivo model.
CONCLUSIONS: The described method can be used to assess the effects of chemotherapeutic agents on the growth of tumors that have been grafted onto the CAM and further advance personalized cancer therapy. In summary, we established a promising protocol that enables in vivo real-time tracking of tumor growth in the CAM model using a digital microscope. PMID: 32925020 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - September 8, 2020 Category: Hematology Authors: Troebs J, Asam C, Pion E, Prantl L, Aung T, Haerteis S Tags: Clin Hemorheol Microcirc Source Type: research

Spheroid formation of human keratinocyte: Balancing between cell-substrate and cell-cell interaction.
CONCLUSIONS: Conclusively, the decreased cell- substrate adhesion was the main driven force in the spheroid formation. This finding might serve as a design criterion for biomaterials facilitating the formation of epithelial spheroids. PMID: 32925021 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - September 8, 2020 Category: Hematology Authors: Nie Y, Xu X, Wang W, Ma N, Lendlein A Tags: Clin Hemorheol Microcirc Source Type: research

Imaging of breast implant and implant-associated complications: Capsular contracture and intra- or extracapsular rupture.
CONCLUSION: To detect early complications after breast implant surgery, a regular clinical examination is indispensable. Imaging methods complement each other and if they are used multimodal, it is easier to identify early complications. Modern diagnostic modalities like ultrasound and magnetic resonance imaging expand the spectrum and improve diagnostic safety. PMID: 32925022 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - September 8, 2020 Category: Hematology Authors: Georgieva M, Kammerer S, Prantl L, Jung F, Stroszczynski C, Jung EM Tags: Clin Hemorheol Microcirc Source Type: research

Signal intensity in the dentate nucleus after cumulative dose of Gd-EOB-DTPA: First results of a prospective longitudinal study.
Abstract Gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) is a hepatocyte-specific, linear ionic contrast agent for MRI. In comparison to other linear contrast agents Gd-EOB-DTPA is excreted equally through liver and kidneys. This prospective longitudinal study investigates the signal intensity (SI) in the dentate nucleus (DN) on unenhanced T1-weighted images after repetitive application of Gd-EOB-DTPA. 46 patients were included into the study and 107 MRI examinations were performed. Statistical analysis of 25 patients showed no significant correlation between cumulative dose of Gd-EOB-DTPA...
Source: Clinical Hemorheology and Microcirculation - September 8, 2020 Category: Hematology Authors: Michalik K, Beyer L, Zeman F, Wendl C, Rennert J, Fellner C, Stroszczynski C, Wiggermann P Tags: Clin Hemorheol Microcirc Source Type: research

Cutaneous microcirculation in patients with peripheral arterial occlusive disease: Comparison of capillary blood circulation in the nail fold of finger and toe.
In this study the velocity of erythrocytes (very) in finger nailfold capillaries - a vascular area without upstream macroangiopathy - and also in toe nailfold capillaries - a post-stenotic area -was investigated using capillary microscopy in apparently healthy subjects and patients with PAOD. Already in finger nailfold capillaries very of patients with PAOD under resting conditions was significantly lower than in capillaries of healthy subjects. This was also true for the circulation in toe capillaries. In addition, the erythrocyte velocities under resting conditions in the toe capillaries were significantly lower than in ...
Source: Clinical Hemorheology and Microcirculation - September 8, 2020 Category: Hematology Authors: Mrowietz C, Sievers H, Pindur G, Hiebl B, Jung F Tags: Clin Hemorheol Microcirc Source Type: research

Imaging findings of fibrolamellar hepatocellular carcinomas on ultrasonography: A comparison with conventional hepatocellular carcinomas.
CONCLUSIONS: The ultrasonographic features of FLHCC lesions indicate that they are relatively large masses showing the internal hyperechoic area or strip-like attenuation or calcification on the US and hypervascularity with an unenhanced central scar on the CEUS as compared with conventional HCC lesions. PMID: 32924993 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - September 7, 2020 Category: Hematology Authors: Fu T, Ding H, Xu C, Zhu Y, Xue L, Lin F Tags: Clin Hemorheol Microcirc Source Type: research

In vivo detection of breast cancer liver metastases in humanized tumour mice using tumour specific Contrast Agent BR55  ®.
CONCLUSIONS: This study in HTM demonstrated the high feasibility of tumour specific contrast media and standard HRU contrast agents to detect early liver metastases. PMID: 32924994 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - September 7, 2020 Category: Hematology Authors: Bitterer F, Hornung M, Platz Batista da Silva N, Schlitt HJ, Stroszczynski C, Wege AK, Jung EM Tags: Clin Hemorheol Microcirc Source Type: research

Evaluation of a shorter algorithm in an automated analysis of sublingual microcirculation.
Abstract OBJECTIVE: Diagnostic and risk stratification in intensive and emergency medicine must be fast, accurate, and reliable. The assessment of sublingual microcirculation is a promising tool for this purpose. However, its value is limited because the measurement is time-consuming in unstable patients. This proof-of-concept validation study examines the non-inferiority of a reduced frame rate in image acquisition regarding quality, measurement results, and time. METHODS: This prospective observational study included healthy volunteers. Sublingual measurement of microcirculation was performed using a sidest...
Source: Clinical Hemorheology and Microcirculation - September 7, 2020 Category: Hematology Authors: Romano Bruno R, Schemmelmann M, Wollborn J, Kelm M, Jung C Tags: Clin Hemorheol Microcirc Source Type: research

The course of Kaposi's sarcoma, a marker disease for the initial diagnosis of AIDS, under ongoing cART.
d A Abstract While Kaposi's Sarcoma (KS) was common in the 1980s and early 1990s in HIV-positive patients and one of the most common AIDS-defining diseases, its prevalence today has decreased significantly due to the early and widespread use of chimeric antigen receptor T-cell (cART) therapy. The rapid initiation of cART or, if occurring during ongoing cART, an optimization of antiretroviral therapy leads to a healing of this tumour disease in most patients. The aim of the therapy is immune reconstitution, as the immunodeficiency resulting from the HIV disease (reduced CD4+-T helper cells) promotes the development...
Source: Clinical Hemorheology and Microcirculation - September 7, 2020 Category: Hematology Authors: Lutze S, Riebe H, Jünger M, Arnold A Tags: Clin Hemorheol Microcirc Source Type: research

Extended analysis of intratumoral heterogeneity of primary osteosarcoma tissue using 3D-in-vivo-tumor-model.
CONCLUSIONS: Primary osteosarcoma tissue grew on several different CAMs for an extended time period and neovascularization of serial transplanted tumor parts was observed, improving the versatility of the 3D-in-vivo-tumor-model. PMID: 32925008 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - September 7, 2020 Category: Hematology Authors: Feder AL, Pion E, Troebs J, Lenze U, Prantl L, Htwe MM, Phyo A, Haerteis S, Aung T Tags: Clin Hemorheol Microcirc Source Type: research

Functional ultrasound imaging of the venous valve of the great saphenous vein in the area around the crosse using the novel vector flow technique.
CONCLUSION: The crosse as a significant venous structure can be well investigated by V-flow with respect to hemodynamic changes and a resulted reflux. Also associated changes close to the valve can be visualized well. PMID: 32925009 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - September 7, 2020 Category: Hematology Authors: Kammerer S, Stroszczynski C, Jung EM Tags: Clin Hemorheol Microcirc Source Type: research

Effects of gut microbial metabolite trimethylamine N-oxide (TMAO) on platelets and endothelial cells.
sberg J Abstract Thrombotic events result from different pathologies and are the underlying causes of severe diseases like stroke or myocardial infarction. Recent basic research now revealed a link between food uptake, food conversion and gut metabolism. Gut microbial production of trimethylamine N-oxide (TMAO) from dietary nutrients like choline, lecithin and L-carnitine was associated with the development of cardiovascular diseases. Within this review we give a systematic overview about the influence of TMAO on blood components like platelets and endothelial cells which both are involved as key players in thromb...
Source: Clinical Hemorheology and Microcirculation - September 7, 2020 Category: Hematology Authors: Krüger-Genge A, Jung F, Hufert F, Jung EM, Küpper JH, Storsberg J Tags: Clin Hemorheol Microcirc Source Type: research

The novel iron chelator, DIBI, attenuates inflammation and improves outcome in colon ascendens stent peritonitis-induced experimental sepsis.
CONCLUSIONS: DIBI has promising potential for sepsis treatment including its use as a sole or an adjunct therapeutic with antibiotics. PMID: 32925011 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - September 7, 2020 Category: Hematology Authors: Fokam D, Aali M, Dickson K, Scott C, Holbein B, Zhou J, Lehmann C Tags: Clin Hemorheol Microcirc Source Type: research

The effects of oscillatory temperature on HaCaT keratinocyte behaviors.
CONCLUSIONS: ΔT conditions resulted in the re-arrangement of the cytoskeleton in HaCaT cells, which showed similarity to the temperature-induced disassemble and re-assemble of cytoskeletons in keratinocyte in vivo. The altered cytoskeleton arrangement resulted in the cell enlargement and stiffening, which reflected the changes in cellular functions. The application of oscillatory temperature in the in vitro culture of keratinocytes provides a way to gain more insights into the role of skin in response to environmental stimuli and maintaining its homeostasis in vivo. PMID: 32925012 [PubMed - as supplied by publis...
Source: Clinical Hemorheology and Microcirculation - September 7, 2020 Category: Hematology Authors: Nie Y, Xu X, Wang W, Ma N, Lendlein A Tags: Clin Hemorheol Microcirc Source Type: research

The diagnostic performance of perfusion CT in the detection of local tumor recurrence in head and neck cancer.
Abstract BACKGROUND: Detecting local tumor recurrence from post-treatment changes in head and neck cancer (HNC) remains a challenge. Based on the hypothesis that post-therapeutically altered tissue is bradytroph, lower perfusion values are expected in perfusion CT (PCT) while higher perfusion values are expected in recurrent malignant tissue. OBJECTIVES: This prospective study investigates PCT for post-treatment recurrent HNC detection with a maximum slope algorithm. METHODS: A total of 80 patients who received PCT of the head and neck for post-therapy follow-up, of which 63 had no tumor recurrence and 1...
Source: Clinical Hemorheology and Microcirculation - September 7, 2020 Category: Hematology Authors: Troeltzsch D, Niehues SM, Fluegge TV, Neckel N, Heiland M, Hamm B, Shnayien S Tags: Clin Hemorheol Microcirc Source Type: research

Is major burn injury associated with coagulopathy? The value of thrombelastometry in the detection of coagulopathy in major burn injury: A prospective observational study.
CONCLUSION: This study points towards a more complex picture and higher occurrence of DIC in burn patients when thrombelastometric measurements like ROTEM® are taken into account in addition to standard coagulation parameters. PMID: 32925014 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - September 7, 2020 Category: Hematology Authors: Lonic D, Heidekrueger PI, Bosselmann T, Niclas Broer P, Gertler R, Wolfgang Martin K, Prantl L, Ninkovic M, Giunta R, Ehrl D Tags: Clin Hemorheol Microcirc Source Type: research

Intracardiac echocardiography to enable successful edge-to-edge transcatheter tricuspid valve repair in patients with insufficient TEE quality.
CONCLUSIONS: ICE guidance may offer an additional tool to guide EETVr with the MitraClip device in patients with poor TEE quality, as it enables successful results without impairing procedural safety. PMID: 32925015 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - September 7, 2020 Category: Hematology Authors: Curio J, Abulgasim K, Kasner M, Rroku A, Lauten A, Lendlein A, Landmesser U, Reinthaler M Tags: Clin Hemorheol Microcirc Source Type: research

Functional requirements for polymeric implant materials in head and neck surgery.
CONCLUSIONS: A sufficient stability of the polymeric material is a requirement for the pharyngeal reconstruction with implant materials. PMID: 32925016 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - September 7, 2020 Category: Hematology Authors: Rickert D, Steinhart H, Lendlein A Tags: Clin Hemorheol Microcirc Source Type: research

The diagnostic performance of contrast-enhanced ultrasound (CEUS) for evaluating hepatocellular carcinoma (HCC) juxtaposed to MRI findings; a retrospective single-center analysis of 292 patients.
CONCLUSION: With a distinguished safety profile CEUS shows a high diagnostic accuracy in assessing HCC compared to corresponding results from MRI scans. PMID: 32925017 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - September 7, 2020 Category: Hematology Authors: Schwarze V, Marschner C, Völckers W, Negrão de Figueiredo G, Rübenthaler J, Clevert DÁ Tags: Clin Hemorheol Microcirc Source Type: research

Contrast-enhanced ultrasound (CEUS) in the diagnostic evaluation of popliteal artery aneurysms, a single-center study.
CONCLUSION: CEUS is a useful and safe tool for in real-time evaluation of PAAs in the pre-/post-treatment status. In addition to conventional (Doppler) ultrasound and as an alternative tool to more elaborate imaging modalities, CEUS might be integrated in the future diagnostic work-up and follow-up of PAA patients. PMID: 32925018 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - September 7, 2020 Category: Hematology Authors: Schwarze V, Marschner C, Negrão de Figueiredo G, Rübenthaler J, Clevert DÁ Tags: Clin Hemorheol Microcirc Source Type: research

Protective effect of inhibiting TRPM7 expression on hypoxia post-treatment H9C2 cardiomyocytes.
CONCLUSION: Knockdown of TRPM7 can significantly reduce reperfusion injury in H9C2 cells, reduce the degree of apoptosis, and the TRPM7 interference vector can inhibit the expression of TRPM7 and have a certain protective effect on the reperfusion injury of H9C2 cells. PMID: 32924998 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - September 6, 2020 Category: Hematology Authors: Yang J, Hu S, Huang L, Zhou J, Xiang H, Yang H, Cheng H, Tang Y Tags: Clin Hemorheol Microcirc Source Type: research

Hydrogen sulphide reduces the activity of human endothelial cells.
CONCLUSIONS: Summarizing, GYY dose dependently and reversibly reduces the activity of endothelial cells. PMID: 32924989 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - August 27, 2020 Category: Hematology Authors: Grambow E, Klee G, Xie W, Schafmayer C, Vollmar B Tags: Clin Hemorheol Microcirc Source Type: research

Analysis of pigmented skin lesions and malignant melanoma by Laser Doppler flowmetry - Report of different cases and further analysis by a neuronal network.
CONCLUSION: In addition to clinical parameters, such as color and border, information from the LDF can help in the diagnosis of malignant melanomas. The LDF provides information on the vascularization of the skin lesion. PMID: 32924991 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - August 27, 2020 Category: Hematology Authors: Konschake W, Haase H, Jünger M, Lutze S, Arnold A Tags: Clin Hemorheol Microcirc Source Type: research

Contrast-enhanced ultrasound-guided thrombin injection in the management of iatrogenic pseudoaneurysm (PSA): A case report and review of literatures.
Abstract Pseudoaneurysm (PSA) formation is the most common arterial complication of endovascular procedures requiring arterial puncture. The present study reported a case of a 72-year-old male patient with iatrogenic femoral artery PSA treated with contrast-enhanced ultrasound (CEUS) - guided thrombin injection. Conventional ultrasound (US) and CEUS were used to diagnose, guide treatment, and evaluate the treatment efficacy. In the case, the PSA was successfully occluded with 1000 IU of thrombin. During the follow-up after 48 hours of thrombin injection, US found that the PSA had complete thrombosis without arteri...
Source: Clinical Hemorheology and Microcirculation - August 27, 2020 Category: Hematology Authors: Li XL, Xie CY, Xu HX Tags: Clin Hemorheol Microcirc Source Type: research

Concealed role of red blood cells in pathogenesis of pulmonary arterial hypertension: Decreased red blood cell nitric oxide generation and effect of Rho-Kinase inhibitor fasudil.
CONCLUSIONS: This study provides first evidences for decreased RBC eNOS activity due to its ROCK mediated negative regulation under PAH conditions. Considering increased ROCK activity contributes to progression of PAH, ROCK inhibition influences NO bioavailability through RBC eNOS, in addition to endothelial eNOS. PMID: 32804118 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - August 6, 2020 Category: Hematology Authors: Basarici I, Özen N, Kilavuz E, Kısak F, Basrali F, Yaras N, Koksoy S, Celik ML, Ulker P Tags: Clin Hemorheol Microcirc Source Type: research

Silencing of long noncoding RNA TUG1 inhibits viability and promotes apoptosis of acute myeloid leukemia cells by targeting microRNA-221-3p/KIT axis.
CONCLUSIONS: TUG1 silencing retarded viability and promoted apoptosis of AML cells via regulating miR-221-3p/KIT axis, providing a potential therapeutic target for AML. PMID: 32804119 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - August 6, 2020 Category: Hematology Authors: Zhang X, Yang L, Xu G Tags: Clin Hemorheol Microcirc Source Type: research

Which remote ischemic preconditioning protocol is favorable in renal ischemia-reperfusion injury in the rat?
Abstract BACKGROUND: The optimal timing of remote ischemic preconditioning (RIPC) in renal ischemia-reperfusion (I/R) injury is still unclear. We aimed to compare early- and delayed-effect RIPC with hematological, microcirculatory and histomorphological parameters. METHODS: In anesthetized male CrI:WI Control rats (n = 7) laparotomy and femoral artery cannulation were performed. In I/R group (n = 7) additionally a 45-minute unilateral renal ischemia with 120-minute reperfusion was induced. The right hind-limb was strangulated for 3×10 minutes (10-minute intermittent reperfusion) 1 hour (RIPC-1 g...
Source: Clinical Hemorheology and Microcirculation - August 6, 2020 Category: Hematology Authors: Varga G, Ghanem S, Szabo B, Nagy K, Pal N, Tanczos B, Somogyi V, Barath B, Deak A, Matolay O, Bidiga L, Peto K, Nemeth N Tags: Clin Hemorheol Microcirc Source Type: research

The value of conventional sonography and ultrasound elastography in decision-making for thyroid nodules in different categories of the Bethesda system for reporting thyroid cytopathology.
PMID: 32716351 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - July 18, 2020 Category: Hematology Authors: Wu Q, Li Y, Liu Y, Shen J, Wang Y, Yi X, Hu B Tags: Clin Hemorheol Microcirc Source Type: research

Ultrasound combined with biochemical parameters can be used to differentiate parathyroid carcinoma from benign tumors in patients with primary hyperparathyroidism.
This study is a retrospective study. The study enrolled 17 patients with parathyroid carcinoma (PC) and 57 patients with parathyroid adenoma (PA), confirmed by postoperative pathology, between September 2010 and July 2017. This study retrospectively compared the ultrasonic features of the tumors included echotexture, maximum lesion diameter, shape, margin, blood flow inside the mass, intralesional calcifications, cysts in the mass, and biochemical parameters included serum calcium, phosphorus, parathyroid hormone (PTH), alkaline phosphatase (ALP) levels, gender distribution and age of patients between patients with PC and ...
Source: Clinical Hemorheology and Microcirculation - July 16, 2020 Category: Hematology Authors: Zheng Y Tags: Clin Hemorheol Microcirc Source Type: research

The blood protective effect of autologous platelet separation in aortic dissection.
This study aimed to retrospectively analyze the blood protective effect of autologous platelet separation in operations for acute aortic dissection. METHODS: A total of 130 patients with acute aortic dissection were enrolled into the present study. The average age of these patients was 52.962±10.5061 years old. These patients underwent the modified aortic arch replacement with the elephant trunk technique or endovascular aortic exclusion with covered stent. Among these patients, 68 patients who underwent autologous platelet separation were assigned to the platelet separation group, while the remaining patients ...
Source: Clinical Hemorheology and Microcirculation - July 16, 2020 Category: Hematology Authors: Zhao L, Wang H, Li SS, Xin F, Wu Q, Li ZY, Ma XJ Tags: Clin Hemorheol Microcirc Source Type: research

Monitoring of RBC rheology after cryopreservation to detect autologous blood doping in vivo? A pilot study.
CONCLUSIONS: The data of this pilot study indicate that the increase in RBC deformability might be related to neoformation of RBC after blood donation. The lack of changes in tested parameters might be related to the low re-infused RBC volume which might explain differences to in vitro results. PMID: 32675400 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - July 16, 2020 Category: Hematology Authors: Bizjak DA, Grolle A, Urena JAN, Bloch W, Deitenbeck R, Grau M Tags: Clin Hemorheol Microcirc Source Type: research

SWE combined with ACR TI-RADS categories for malignancy risk stratification of thyroid nodules with indeterminate FNA cytology.
CONCLUSIONS: ACR TI-RADS classification system and shear wave elastography had high diagnostic efficacy for thyroid nodules with interminate FNA cytology. The combination of the two could improve diagnostic sensitivity and accuracy, and could help to differentiate benign and malignant thyroid nodules with interminate FNA cytology. PMID: 32675401 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - July 16, 2020 Category: Hematology Authors: Zhang WB, Li JJ, Chen XY, He BL, Shen RH, Liu H, Chen J, He XF Tags: Clin Hemorheol Microcirc Source Type: research

Analysis of contrast-enhanced ultrasound features of hepatocellular adenoma according to different pathological molecular classifications.
CONCLUSION: Depending on its unique imaging features including enhancement filling pattern, hyper-enhanced subcapsular artery and presence of washout, CEUS might provide helpful diagnostic information for preoperative prediction of various HCA molecular subtypes. PMID: 32675402 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - July 16, 2020 Category: Hematology Authors: Chen K, Dong Y, Zhang W, Han H, Mao F, Zhang Q, Zheng Z, He W, Wang WP Tags: Clin Hemorheol Microcirc Source Type: research

Current opinion on the role of the foot perfusion in limb amputation risk assessment.
Abstract The most important and consulted guidelines dealing with not healing foot ulcers suggest the measurement the foot perfusion (FP) to exclude the critical limb ischemia (CLI) because of the high risk of limb amputation. But the recommended cut-off values of FP fail to include all the heterogeneity of patients of the real-life with a not healing ulcer. Often these patients are diabetics with a moderate PAD but high level of infection. To meet this goal, in 2014, the Society for Vascular Surgery has published the "Lower Extremity Threatened Limb Classification System: Risk stratification based on Wound, ...
Source: Clinical Hemorheology and Microcirculation - July 16, 2020 Category: Hematology Authors: Martini R Tags: Clin Hemorheol Microcirc Source Type: research

Assessment of celiac artery compression using color-coded duplex sonography.
umer MH Abstract BACKGROUND: Median arcuate ligament syndrome (MALS) is a rare condition due to compression of the celiac artery (CA) by an anatomically abnormal median arcuate ligament. With ultrasonography (US) as first-line diagnostic modality in patients with unclear abdominal pain, there is limited data on its diagnostic performance in MALS. OBJECTIVE: To investigate the value of CA peak systolic velocity (PSV) in the workup of patients with suspected MALS. METHODS: Patients with diagnosis of MALS between 2009 and 2019 were referred by Department of Visceral Surgery after clinical and gastroenterolo...
Source: Clinical Hemorheology and Microcirculation - July 16, 2020 Category: Hematology Authors: Römer C, Fischer T, Haase O, Möckel M, Hamm B, Lerchbaumer MH Tags: Clin Hemorheol Microcirc Source Type: research

Prediction of long-term prognosis of  age-related macular degeneration treated by hemorheologic therapy using baseline laboratory indicators - Experimental-clinical model.
CONCLUSION: Implementation of discriminant analysis is a promising method for prediction of prognosis, especially when the patient is at risk of AMD progression, which allows for early and more intensive monitoring and treatment. PMID: 32675405 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - July 14, 2020 Category: Hematology Authors: Blaha M, Langrova H, Blaha V, Andrys C, Stepanov A, Lanska M, Vejrazkova E, Dlouha D, Loefflerova V, Studnicka J, Kostal M Tags: Clin Hemorheol Microcirc Source Type: research

Erythropoetin can partially restore cigarette smoke induced effects on Adipose derived Stem Cells.
CONCLUSION: Exposure to cigarette smoke significantly reduced the regenerative potential of ASCs. Treatment of ASCs exposed to cigarette smoke with EPO has the potential to partially restore their function. PMID: 32651309 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - July 9, 2020 Category: Hematology Authors: Kükrek H, Aitzetmüller M, Vodiškar M, Moog P, Machens HG, Duscher D Tags: Clin Hemorheol Microcirc Source Type: research