Prediction of neurodevelopmental outcomes in SARS-CoV-2 infections
Dear Sir, We read with great interest the scoping review on human coronavirus (HCoV) infections in the nervous system of children by Singer TG et al.[1]. The authors highlighted that the neurological manifestations of HCoV infections(including SARS-CoV-2) can be severe in children with a possible bearing on long-term neurodevelopment. The long-term impact of these infections is not known and needs to be evaluated. They also provided an age-related clinical practice guide for pediatricians for early identification of potential neurodevelopmental impairment. (Source: Pediatric Neurology)
Source: Pediatric Neurology - April 15, 2021 Category: Neurology Authors: Priyanka Madaan, Lokesh Saini, Christa Einspieler Tags: Correspondence Source Type: research

Placental histological features and neurodevelopmental outcomes at two years in very low birth weight infants
We evaluated the rates of placental pathological lesions and their relationship with two-year neurodevelopmental outcomes in very-low-birthweight (VLBW) infants (Source: Pediatric Neurology)
Source: Pediatric Neurology - April 15, 2021 Category: Neurology Authors: Arsenio Spinillo, Mattia Dominoni, Camilla Caporali, Ivana Olivieri, Roberta La Piana, Stefania Longo, Stefania Cesari, Giacomo Fiandrino, Simona Orcesi, Barbara Gardella Tags: Research Paper Source Type: research

On-field Characteristics and Head Impact Magnitude in Youth Tackle Football
This study determined the effect of video-verified collision characteristics on head impact magnitudes in male youth tackle football. (Source: Pediatric Neurology)
Source: Pediatric Neurology - April 15, 2021 Category: Neurology Authors: Rachel K. Le, Melissa N. Anderson, Rachel S. Johnson, Landon B. Lempke, Julianne D. Schmidt, Robert C. Lynall Tags: Research Paper Source Type: research

Prioritizing seizure safety and SUDEP counseling in people with epilepsy and their caregivers during the COVID-19 pandemic
Not applicable (Source: Pediatric Neurology)
Source: Pediatric Neurology - April 15, 2021 Category: Neurology Authors: Robyn Whitney, Rajesh RamachandranNair Tags: Opinion Paper Source Type: research

Adverse Childhood Experiences and Frequent Headache by Adolescent Self-Report
This study examines the relationship of self-reported ACEs to frequent headache in an adolescent cohort. (Source: Pediatric Neurology)
Source: Pediatric Neurology - April 15, 2021 Category: Neurology Authors: Marissa Anto, Sara Jaffee, Gretchen Tietjen, Adys Mendizibal, Christina Szperka Tags: Research Paper Source Type: research

Celiac disease in children: an association with drug-resistant epilepsy
Neurologic manifestations including seizures are commonly reported in patients with celiac disease (CD). We aimed to characterize distinctive features of epilepsy in a pediatric population with CD and the effect of a gluten-free diet (GFD) on seizure burden. (Source: Pediatric Neurology)
Source: Pediatric Neurology - April 14, 2021 Category: Neurology Authors: Shanna Swartwood, Jacob Wilkes, Joshua L. Bonkowsky, Cristina C. Trandafir Tags: Research Paper Source Type: research

Management of CLN1 Disease: International Clinical Consensus
CLN1 disease (neuronal ceroid lipofuscinosis type 1) is a rare, genetic, neurodegenerative lysosomal storage disorder caused by palmitoyl protein thioesterase 1 (PPT1) enzyme deficiency with infantile-, late infantile-, juvenile-, and adult-onset phenotypes. Clinical features include developmental delay, psychomotor regression, seizures, ataxia, movement disorders, visual impairment, and early death. In general, the later the age at symptom onset, the more protracted the disease course. There is a limited evidence base for treatment and no clinical management guidelines to support clinicians who have not previously encount...
Source: Pediatric Neurology - April 9, 2021 Category: Neurology Authors: Erika F. Augustine, Heather R. Adams, Emily de los Reyes, Kristen Drago, Margie Frazier, Norberto Guelbert, Minna Laine, Tanya Levin, Jonathan W. Mink, Miriam Nickel, Danielle Peifer, Angela Schulz, Alessandro Simonati, Meral Topcu, Joni A. Turunen, Ruth Tags: Research Paper Source Type: research

Pediatric autoimmune encephalitis and its relationship with infection
Autoimmune encephalitis (AE) is an increasingly recognized inflammatory disorder of the central nervous system and is most often characterized by antibodies against intracellular and neuronal surface antigens. AE is a devastating disease that may result in developmental delay or regression in children. However, the pathogenesis of AE is not clear, and immune system disorders after infection likely play an important role in AE. Many studies have reported that patients with herpes simplex virus encephalitis develop anti-N-methyl-D-aspartate (NMDA) receptor encephalitis after antiviral treatment. (Source: Pediatric Neurology)
Source: Pediatric Neurology - April 7, 2021 Category: Neurology Authors: Qinrui Li, Na Fu, Ying Han, Jiong Qin Tags: Review Article Source Type: research

Alteration of the Arcuate Fasciculus in Jacobsen Syndrome shown by Diffusion Tensor Imaging
We describe the longitudinal magnetic resonance imaging (MRI) changes of the brain in a child with JBS, magnetic resonance spectroscopy (MRS) and diffusi on tensor imaging (DTI) findings showing alteration in white matter microstructural integrity and alteration in AF. (Source: Pediatric Neurology)
Source: Pediatric Neurology - April 5, 2021 Category: Neurology Authors: Ananyaa Kumar, Kazuki Sakakura, Takumi Mitsuhashi, Anastasia Railean, Aimee F. Luat Tags: Short Communication Source Type: research

The Smile Sign
The neurologist ’s diagnostic process is often held in reverence among academic clinicians. We neurologists, who “understand the brain” as is often said, identify obscure patterns through arcane physical diagnostics. Yet we have had our difficulties speaking plainly when addressing the question of functional neurological disorder [1]. (Source: Pediatric Neurology)
Source: Pediatric Neurology - April 3, 2021 Category: Neurology Authors: Peter M. Bingham Tags: Opinion Paper Source Type: research

Selective Eating in Autism Spectrum Disorder Leading to Hair Color Change
Based on the study by Swed Tobia et al.1 on scurvy caused by selective eating in patients with autism spectrum disorder (ASD), we previously reported a patient with selective eating in ASD leading to kwashiorkor and brain edema.2 Children with ASD are considered selective eaters, resulting in malnutrition.3 These reports emphasized the diversity in the symptoms depending on the types of food consumed by ASD patients. (Source: Pediatric Neurology)
Source: Pediatric Neurology - April 2, 2021 Category: Neurology Authors: Yuji Maruo, Kimiaki Uetake, Kiyoshi Egawa, Hideaki Shiraishi Tags: Correspondence Source Type: research

Distinct Clinical and Radiographic Phenotypes in Pediatric Moyamoya Patients
Moyamoya arteriopathies exhibit different phenotypes based on underlying etiologies. Frequent TIAs is a common phenotype of MMD and symptomatic stroke presentation a common feature of MMD and MMS-SCD, while unilateral disease and low infarct burden is common in MMS-NF1. In addition, absence of ivy sign is a common phenotype in MMS-SCD. (Source: Pediatric Neurology)
Source: Pediatric Neurology - April 2, 2021 Category: Neurology Authors: Matsanga Leyila Kaseka, Mahmoud Slim, Prakash Muthusami, Peter B. Dirks, Robyn Westmacott, Andrea Kassner, Ishvinder Bhathal, Suzan Williams, Manohar Shroff, William Logan, Mahendranath Moharir, Daune L. MacGregor, Elizabeth Pulcine, Gabrielle A. deVeber, Tags: Research Paper Source Type: research

Prolonged fever - an atypical presentation in mog antibody associated disorders
We report 12 cases of MOG-Ab Associated Disorders (MOGAD) who all manifested prolonged fever (PF) lasting several weeks during the course of the illness. Eight of these had no clinical /imaging evidence of demyelination until much later. Three clinical presentations were: fever of unknown origin (4 /12), aseptic meningitis (4/12) and PF along with established acute demyelination syndrome (4/12). Leukocytosis, and raised inflammatory markers along with CSF pleocytosis were almost universal. The first two presentations frequently caused diagnostic confusion, as MOGAD was not considered until several weeks after disease onset...
Source: Pediatric Neurology - April 2, 2021 Category: Neurology Authors: Vrajesh Udani, Rahul Badheka, Neelu Desai Tags: Short Communication Source Type: research

Diabetes in individuals with Tuberous Sclerosis Complex treated with mTOR inhibitors
Tuberous sclerosis complex (TSC) is a genetic disorder that is manifested in multiple body systems. Initiation of an mTOR inhibitor, either everolimus or sirolimus, are now routinely prescribed for multiple clinical manifestations of TSC, including subependymal giant cell astrocytoma and epilepsy. These medications are generally well tolerated. Side effects previously identified in well-designed clinical trials tend to be mild in severity and are readily manageable. Regulatory approvals for; the treatment of TSC have expanded and use of everolimus and sirolimus; clinically, enlarging clinician experience and enabling ident...
Source: Pediatric Neurology - April 1, 2021 Category: Neurology Authors: Karen Agricola, Gabrielle Stires, Darcy A. Krueger, Jamie K. Capal, David N. Franz, David M. Ritter Tags: Short Communication Source Type: research

Diabetes in individual with Tuberous Sclerosis Complex treated with mTOR inhibitors
Tuberous sclerosis complex (TSC) is a genetic disorder that is manifested in multiple body systems. Initiation of an mTOR inhibitor, either everolimus or sirolimus, are now routinely prescribed for multiple clinical manifestations of TSC, including subependymal giant cell astrocytoma and epilepsy. These medications are generally well tolerated. Side effects previously identified in well-designed clinical trials tend to be mild in severity and are readily manageable. Regulatory approvals for; the treatment of TSC have expanded and use of everolimus and sirolimus; clinically, enlarging clinician experience and enabling ident...
Source: Pediatric Neurology - April 1, 2021 Category: Neurology Authors: Karen Agricola, Gabrielle Stires, Darcy A. Krueger, Jamie K. Capal, David N. Franz, David M. Ritter Tags: Short Communication Source Type: research

Isolated third cranial nerve palsy and COVID 19 infection in a child
We have read with interest the case of post-COVID 19 transverse myelitis in a child described by Harsheen Kaur et al. [1]. (Source: Pediatric Neurology)
Source: Pediatric Neurology - April 1, 2021 Category: Neurology Authors: Valentina Lonardi, Davide Meneghesso, Giulia Debertolis, Jacopo N. Pin, Margherita Nosadini, Stefano Sartori Tags: Letter from the Editor Source Type: research

Editorial Board and Masthead
(Source: Pediatric Neurology)
Source: Pediatric Neurology - March 25, 2021 Category: Neurology Source Type: research

Table of Contents
(Source: Pediatric Neurology)
Source: Pediatric Neurology - March 25, 2021 Category: Neurology Source Type: research

A Rare Pediatric Case of Marijuana-Induced Reversible Cerebral Vasoconstriction Syndrome (RCVS)
Reversible cerebral vasoconstriction syndrome (RCVS) describes a sudden constriction of the cerebral vessels that results in acute-onset, “thunderclap” headaches with or without neurologic deficits. Clinical symptoms resolve within 1 month, and vasoconstriction resolves within 3 months1. While RCVS is rare in pediatrics, the most common etiologies include sickle cell, systemic lupus or immunosuppressive agents2. In the current lit erature, there are no reported cases of pediatric RCVS in which cannabis use is the precipitating factor. (Source: Pediatric Neurology)
Source: Pediatric Neurology - March 25, 2021 Category: Neurology Authors: Laura Bliss, Bridget McGowan, Anisa Rahman Tags: Short Communication Source Type: research

Time to treatment in pediatric convulsive refractory status epilepticus: the weekend effect
Evaluate the influence of weekends and holidays on time to treatment of pediatric refractory convulsive status epilepticus. (Source: Pediatric Neurology)
Source: Pediatric Neurology - March 25, 2021 Category: Neurology Authors: Cristina Barcia Aguilar, Marta Amengual-Gual, Iv án Sánchez Fernández, Nicholas S. Abend, Anne Anderson, Brian Appavu, Ravindra Arya, J. Nicholas Brenton, Jessica L. Carpenter, Kevin E. Chapman, Justice Clark, Raquel Farias-Moeller, William D. Gaillard Tags: Research Paper Source Type: research

Acute Fulminant Cerebellitis in Paediatric COVID-19 Infection- rare, yet a potentially treatable clinical entity
This past year, coronavirus disease 2019 (COVID-19) has displayed widespread systemic manifestations including neurological features (upto 36%) such as stroke, myelitis and encephalitis.1,2 We would like to draw attention to two cases of paediatric COVID-19-associated acute fulminant cerebellitis and discuss treatment challenges. (Source: Pediatric Neurology)
Source: Pediatric Neurology - March 24, 2021 Category: Neurology Authors: Sanjiv Sharma, Jigish Ruparelia, Suryanarayanan Bhaskar, Sarbesh Tiwari, Vijaya Lakshmi Nag, Samhita Panda Tags: Short Communication Source Type: research

Copper toxicity associated with an ATP7A-related complex phenotype
The ATP7A gene encodes a copper transporter whose mutations cause Menkes disease, occipital horn syndrome (OHS) and, less frequently,ATP7A-related distal hereditary motor neuropathy (dHMN). Here we describe a family with OHS caused by a novel mutation in theATP7A gene, including a patient with a comorbid dHMN that worsened markedly after being treated with copper histidinate. (Source: Pediatric Neurology)
Source: Pediatric Neurology - March 24, 2021 Category: Neurology Authors: Daniel Natera-de Benito, Abel Sola, Paulo Rego Sousa, Susana Boronat, Jessica Exp ósito-Escudero, Laura Carrera-García, Carlos Ortez, Cristina Jou, Jordi Muchart, Monica Rebollo, Judith Armstrong, Jaume Colomer, Àngels Garcia-Cazorla, Janet Hoenicka, F Tags: Short Communication Source Type: research

Clinical features and outcomes of anti-N-methyl-d-aspartate receptor encephalitis in infants and toddlers
To describe the clinical features and outcomes of anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis in infants and toddlers. (Source: Pediatric Neurology)
Source: Pediatric Neurology - March 11, 2021 Category: Neurology Authors: Changhong Ren, Weihua Zhang, Xiaotun Ren, Jiuwei Li, Changhong Ding, Xiaohui Wang, Haitao Ren, Fang Fang Tags: Research Paper Source Type: research

MR imaging findings in a neonate with COVID -19 associated encephalitis
COVID-19 continues to wreak havoc in many parts of the globe. Children with COVID-19 are generally asymptomatic or have milder symptoms compared to adults. Neurological symptoms and neuroimaging abnormalities in children with COVID-19 disease are frequently due to parainfectious immune mediated phenomena or thromboembolic disease and include acute disseminated encephalomyelitis (ADEM), autoimmune encephalitis, Guillian-Barre syndrome, acute flaccid paralysis, myelitis, cranial nerve enhancement, vascular territory infarcts and microhemorrhages (1, 2). (Source: Pediatric Neurology)
Source: Pediatric Neurology - March 8, 2021 Category: Neurology Authors: Paul J. Martin, Marcia Felker, Rupa Radhakrishnan Tags: Correspondence Source Type: research

Virtual Education during COVID-19 and Beyond
The Children ’s Mercy Kansas City Neurology Division has 113 division members (23 faculty, 16 advanced practice nurses (APRNs), 5 residents/fellows, 27 nurses, 42 other learners) across 5 locations, which creates obstacles for engaging learners in educational conferences. While previously some conferences were live-streamed, lectures were not recorded, and most were attended solely by trainees and a few select faculty. However, COVID-19 and social distancing prompted rapid development and implementation of a complete virtual curriculum. (Source: Pediatric Neurology)
Source: Pediatric Neurology - March 8, 2021 Category: Neurology Authors: Rose Gelineau-Morel, Jennifer Dilts Tags: Short Communication Source Type: research

Epilepsy outcome at four years in a randomized clinical trial comparing oral prednisolone and intra-muscular ACTH in West syndrome
A majority of children diagnosed with West syndrome continued to have seizures at four years of age, although most were controlled on antiseizure medication. The long-term risk of developing epilepsy or its control was the same, regardless of whether ACTH or prednisolone was initially used as treatment. (Source: Pediatric Neurology)
Source: Pediatric Neurology - March 8, 2021 Category: Neurology Authors: Jithangi Wanigasinghe, Carukshi Arambepola, Shalini Sri Ranganathan, Kasun Jayasundara, Ashangi Weerasinghe, Piyumi Wickramarachchi Tags: Research Paper Source Type: research

Amelioration of Levetiracetam- induced behavioral side effects by Pyridoxine-Randomized double blinded controlled study
Levetiracetam is a relatively new generation antiseizure drug approved for the treatment of focal and generalized seizures. Despite its favorable side effect profile and minimal drug-drug interactions, neuropsychiatric side effects are reported in up to 13% of children. A few case series have suggested that supplementation of pyridoxine may mitigate these side effects, but controlled trials are lacking. To address this issue, a randomized interventional study was carried out in a pediatric tertiary hospital to qualify and quantify the potential beneficial effect of pyridoxine in attenuating the neuropsychiatric side effect...
Source: Pediatric Neurology - March 8, 2021 Category: Neurology Authors: Adel Mahmoud, Sadia Tabassum, Shoaa Al Enazi, Nahed Lubbad, Ali Al Wadei, Ali Al Otaibi, Lamya Jad, Ruba Benini Tags: Research Paper Source Type: research

Symptom prevalence and genotype-phenotype correlations in patients with TANGO2-related metabolic encephalopathy and arrhythmias (TRMEA)
To describe the known genotypes and variable phenotypic characteristics of patients diagnosed with TANGO2-related metabolic encephalopathy and arrhythmias (TRMEA). (Source: Pediatric Neurology)
Source: Pediatric Neurology - March 8, 2021 Category: Neurology Authors: Allison R. Powell, Elizabeth G. Ames, Erin Neil Knierbein, Mark C. Hannibal, Samuel J. Mackenzie Tags: Research Paper Source Type: research

Hyperbilirubinemia and asphyxia in children with dyskinetic cerebral palsy
We aimed to study the clinical, etiological and radiological characteristics in children with dyskinetic cerebral palsy (DCP) and to compare the etiological subtypes of hyperbilirubinemia and perinatal asphyxia. (Source: Pediatric Neurology)
Source: Pediatric Neurology - March 4, 2021 Category: Neurology Authors: Arushi Gahlot Saini, Naveen Sankhyan, Prahbhjot Malhi, Chirag Ahuja, Niranjan Khandelwal, Pratibha Singhi Tags: Research Paper Source Type: research

Multi-Center Research Data of Epilepsy Management in Patients with Sturge-Weber Syndrome
Epilepsy in the classic form of Sturge-Weber syndrome (SWS) is common and many important questions remain regarding treatment outcomes. We aimed to analyze a large multi-center database with focus on neurological drug treatment in different demographic and SWS characteristic groups. (Source: Pediatric Neurology)
Source: Pediatric Neurology - March 4, 2021 Category: Neurology Authors: Lindsay F. Smegal, Alison J. Sebold, Adrienne M. Hammill, Csaba Juhasz, Warren D. Lo, Daniel K. Miles, Angus A. Wilfong, Alex V. Levin, Brian Fisher, Karen L. Ball, Anna L. Pinto, Anne M. Comi, National Institutes of Health Sponsor: Rare Disease Clinical Tags: Research Paper Source Type: research

The Role of Mentorship and Collaboration in the Fall and Rebirth of the Ketogenic Diet
The ketogenic diet is currently enjoying a medical and cultural moment as it approaches its century anniversary in July 2021. However, this is not the first time the ketogenic diet has been in the spotlight. In fact, in the 1920s and 1930s, it was one of the more popular treatments for epilepsy. The ketogenic diet emerged from a tradition of fasting treatments for epilepsy. Russel M. Wilder, an endocrinologist at Mayo Clinic, suggested that ketosis could instead be achieved by use of a high fat diet. (Source: Pediatric Neurology)
Source: Pediatric Neurology - March 3, 2021 Category: Neurology Authors: Eva Catenaccio, Ann M. Bergin, Anna L.R. Pinto, Katherine Nickels, Eric H. Kossoff Tags: Opinion Paper Source Type: research

Epidemiology, diagnostics and management of vein of Galen malformation
Vein of Galen malformation (VGM) is a rare congenital intracerebral vascular malformation. The intention of this study was to gain reliable data about epidemiology, clinical manifestations and pre-, peri- and post-interventional treatment strategies in Germany. (Source: Pediatric Neurology)
Source: Pediatric Neurology - March 2, 2021 Category: Neurology Authors: Francisco Brevis Nu ñez Tags: Research Paper Source Type: research

Editorial Board and Masthead
(Source: Pediatric Neurology)
Source: Pediatric Neurology - February 18, 2021 Category: Neurology Source Type: research

Table of Contents
(Source: Pediatric Neurology)
Source: Pediatric Neurology - February 18, 2021 Category: Neurology Source Type: research

Early Identification of Cerebral Palsy using Neonatal MRI and General Movements Assessment in a Cohort of High-Risk Term Neonates
Cerebral palsy (CP) is the most common motor disability of childhood. Its early identification is an important priority for parents and is critical for access to early intervention resources, which may optimize function. (Source: Pediatric Neurology)
Source: Pediatric Neurology - February 15, 2021 Category: Neurology Authors: Hannah C. Glass, Yi Li, Marisa Gardner, A. James Barkovich, Iona Novak, Charles E. McCulloch, Elizabeth E. Rogers Tags: Research Paper Source Type: research

Immediate Post-operative Electroencephalography Monitoring in Pediatric Moyamoya Disease and Syndrome
Moyamoya disease and syndrome are progressive steno-occlusive cerebrovascular diseases that manifest clinically with ischemic episodes. There is evidence for the use of electroencephalography (EEG) in preoperative and long-term postoperative evaluation of these patients, as well as in the intraoperative period to monitor for changes correlated with perioperative ischemic events. However, the utility of EEG in the immediate post-procedure time period has not previously been described. (Source: Pediatric Neurology)
Source: Pediatric Neurology - February 14, 2021 Category: Neurology Authors: Anna L. Huguenard, Rejean M. Guerriero, Stuart R. Tomko, David D. Limbrick, Gregory J. Zipfel, Kristin P. Guilliams, Jennifer M. Strahle Tags: Research Paper Source Type: research

Follow the Money: Childhood Healthcare Disparities Magnified by COVID-19
There are two primary choices in life: to accept conditions as they exist, or accept the responsibility for changing them.Denis Waitley (Source: Pediatric Neurology)
Source: Pediatric Neurology - February 8, 2021 Category: Neurology Authors: Steven Pavlakis, E. Steve Roach Tags: Editorial Source Type: research

Pediatric Autoimmune Ocular Myasthenia Gravis: Evaluation of presentation and treatment outcomes in a large cohort
Investigate clinical presentation, course, and treatment response of pediatric ocular myasthenia gravis (OMG) in a large single-center cohort. (Source: Pediatric Neurology)
Source: Pediatric Neurology - February 4, 2021 Category: Neurology Authors: Kristen S. Fisher, Jason Gill, Hannah F. Todd, Michael B. Yang, Michael A. Lopez, Farida Abid, Timothy Lotze, Veeral Shah Tags: Research Paper Source Type: research

Lingual Seizures from Familial Cerebral Cavernous Malformations in a 4-year-old Child
Cerebral cavernous malformations (CCMs) are irregular clusters of dilated sinusoidal vessels in the brain, with up to 50% being familial1. Autosomal dominant mutations in KRIT1, CCM2, and PDCD10 account for 80% of familial cases2. Focal seizures are the presenting symptom in 50% of cases1. CCMs are best seen on magnetic resonance imaging (MRI) brain T2 gradient echo or T2 star-weighted angiography sequence. (Source: Pediatric Neurology)
Source: Pediatric Neurology - February 4, 2021 Category: Neurology Authors: Chethan K. Rao, Raj D. Sheth Source Type: research

Brain Derived Neurotrophic Factor in Neonatal Seizures
Brain derived neurotrophic factor (BDNF), a member of the neurotrophin family, has an extensively studied classical role in neuronal growth, differentiation, survival, and plasticity. Neurotrophic, from the Greek neuro and trophos, roughly translates as “vital nutrition for the brain.” During development, BDNF and its associated receptor tyrosine receptor kinase B (TrkB) are tightly regulated as they influence the formation and maturation of neuronal synapses. Preclinical research investigating the role of BDNF in neurological disorders has foc used on the effects of decreased BDNF expression on the development...
Source: Pediatric Neurology - February 4, 2021 Category: Neurology Authors: Brennan J. Sullivan, Shilpa D. Kadam Tags: Review Article Source Type: research

Clinical Experience with Gene Therapy in Older Spinal Muscular Atrophy Patients
Onasemnogene abeparvovec was recently approved for the treatment of Spinal Muscular Atrophy (SMA) in children under 2 years; however, clinical trials were primarily completed in children less than 7 months, and so practical experience dosing older children began in summer 2019. Here, we look at the safety and efficacy of onasemnogene in seven infants older than 7 months who were treated at our center. (Source: Pediatric Neurology)
Source: Pediatric Neurology - February 4, 2021 Category: Neurology Authors: Susan E. Matesanz, Vanessa Battista, Jean Flickinger, Jennifer N. Jones, Elizabeth A. Kichula Source Type: research

Coronavirus infections in the nervous system of children: a scoping review making the case for long-term neurodevelopmental surveillance
Although rare, neurologic manifestations of HCoV infections can cause severe disease in children which pose a threat to long-term neurodevelopment. The case literature suggests a critical gap in knowledge of the long-term impacts on child neurodevelopment of these infections. This gap that will need to be filled as the current SARS-CoV-2 pandemic continues to spread globally in order to facilitate optimal outcomes in recovering children. (Source: Pediatric Neurology)
Source: Pediatric Neurology - January 28, 2021 Category: Neurology Authors: Timothy G. Singer, Karen Evankovich, Kristen Fisher, Gail Demmler Harrison, Sarah R. Risen Tags: Review Article Source Type: research

Measuring Quality of Epilepsy Care: The AAN Quality Measures
measures are tools that can help measure healthcare steps, outcomes, patient reported outcomes, and structures of organizations. Quality measures are not guidelines. Quality measures implement guidelines and medical evidence when a gap in care exists. The American Academy of Neurology has developed several quality measure sets in various field within neurology. In 2009, the first epilepsy quality measure set was developed which was recently updated. (Source: Pediatric Neurology)
Source: Pediatric Neurology - January 25, 2021 Category: Neurology Authors: Anup D. Patel Tags: Research Paper Source Type: research

In Silico Predictions of KCNQ Variant Pathogenicity in Epilepsy
Variants in KCNQ2 and KCNQ3 may cause benign neonatal familial seizures (BNFS) and early infantile epileptic encephalopathy (EIEE). Previous reports suggest that in silico models cannot predict pathogenicity accurately enough for clinical use. Here we sought to establish a model to accurately predict the pathogenicity of KCNQ2 and KCNQ3 missense variants based on available in silico prediction models. (Source: Pediatric Neurology)
Source: Pediatric Neurology - January 25, 2021 Category: Neurology Authors: David M. Ritter, Paul S. Horn, Katherine D. Holland Tags: Research Paper Source Type: research

Ectopic Burden via Holter Monitors in Friedreich Ataxia
Friedreich ataxia is the most commonly inherited ataxia; nearly 60% of deaths are cardiac in nature, with one in eight deaths due to arrhythmia. Additional or irregular heartbeats, measured as ectopy, can be quantified using portable heart rhythm monitoring. We sought to describe the ectopic burden in Friedreich ataxia. (Source: Pediatric Neurology)
Source: Pediatric Neurology - January 22, 2021 Category: Neurology Authors: Erika Mejia, Abigail Lynch, Patrick Hearle, Oluwatimilehin Okunowo, Heather Griffis, Maully Shah, David Lynch, Kimberly Y. Lin Tags: Original Article Source Type: research

Ectopic Burden Via Holter Monitors in Friedreich ’s Ataxia
Friedreich Ataxia (FRDA) is the most commonly inherited ataxia; nearly 60% of deaths are cardiac in nature, with 1 in 8 deaths due to arrhythmia. Additional or irregular heartbeats, measured as ectopy, can be quantified using portable heart rhythm monitoring. We sought to describe the ectopic burden in FRDA. (Source: Pediatric Neurology)
Source: Pediatric Neurology - January 22, 2021 Category: Neurology Authors: Erika Mejia, Abigail Lynch, Patrick Hearle, Oluwatimilehin Okunowo, Heather Griffis, Maully Shah, David Lynch, Kimberly Y. Lin Tags: Research Paper Source Type: research

Longitudinal Stability of Spatial Inattention in Children with Perinatal Stroke
This study is a longitudinal analysis of children with perinatal infarcts, with the goals of determining the pattern of inattention found in children with both left and right hemisphere lesions, and whether or not this pattern shows signs of change over time. (Source: Pediatric Neurology)
Source: Pediatric Neurology - January 22, 2021 Category: Neurology Authors: Jessica Kriksciun, Caitlin Knight, Doris Trauner Tags: Research Paper Source Type: research

Editorial Board and Masthead
(Source: Pediatric Neurology)
Source: Pediatric Neurology - January 19, 2021 Category: Neurology Source Type: research

Table of Contents
(Source: Pediatric Neurology)
Source: Pediatric Neurology - January 19, 2021 Category: Neurology Source Type: research

Holocaust and Medicine Legacy for Child Neurology Education and Practice: Contemporary Relevance of a Dark History
Sarah Zhang ’s article in The Atlantic, entitled “The Last Children of Down Syndrome,”1 was sent by a colleague, the father of a child with Down syndrome, and he found it hard to read. More than 95% of pregnant women in Denmark with a prenatal diagnosis of Down syndrome choose to terminate the pregnancy. With prenatal screening becoming more common in the 1980s (offered to every pregnant woman since 2004), Zhang wrote, “a new power was thrust into the hands of ordinary people - the power to decide what kind of life is worth bringing into the world.” Addressing controversial issues, such as qua...
Source: Pediatric Neurology - January 19, 2021 Category: Neurology Authors: Hedy S. Wald, David E. Mandelbaum Tags: Commentary Source Type: research