A Phase 2 Study of AMO-02 (tideglusib) in Congenital and Childhood Onset Myotonic Dystrophy Type 1 (DM1)
GSK3 β is an intracellular regulatory kinase that is dysregulated in multiple tissues in Type 1 myotonic dystrophy (DM1), a rare neuromuscular disorder that manifests at any age. AMO-02 (tideglusib) inhibits GSK3β activity in preclinical models of DM1 and promotes cellular maturation as well as normali zing aberrant molecular and behavioral phenotypes. This Phase 2 study assessed the pharmacokinetics, safety and tolerability, and preliminary efficacy, of AMO-02 in adolescents and adults with Congenital and Childhood-onset DM1. (Source: Pediatric Neurology)
Source: Pediatric Neurology - August 4, 2020 Category: Neurology Authors: Joseph Horrigan, Tiago Bernardino Gomes, Mike Snape, Nikoletta Nikolenko, Alison McMorn, Stuart Evans, Alex Yaroshinsky, Oscar Della Pasqua, Sean Oosterholt, Hanns Lochm üller Tags: Research Paper Source Type: research

Characterization of death in infants with neonatal seizures
Neonatal seizures are associated with death and neurologic morbidity; however, little is known about how neonates with seizures die. (Source: Pediatric Neurology)
Source: Pediatric Neurology - August 4, 2020 Category: Neurology Authors: Monica E. Lemmon, Sonia L. Bonifacio, Ren ée A. Shellhaas, Courtney J. Wusthoff, Rachel G. Greenberg, Janet S. Soul, Taeun Chang, Catherine J. Chu, Sara Bates, Shavonne L. Massey, Nicholas S. Abend, M. Roberta Cilio, Hannah C. Glass, Neonatal Seizure Reg Tags: Research Paper Source Type: research

Cerebrovascular disease in children perinatally infected with HIV in Zambia
High rates of cerebrovascular disease (CVD) have previously been described in pediatric Human Immunodeficiency Virus (HIV). However, little is known about pediatric CVD in the era of antiretroviral therapy (ART), or about the contribution of CVD to HIV-associated neurocognitive disorders. (Source: Pediatric Neurology)
Source: Pediatric Neurology - August 4, 2020 Category: Neurology Authors: Colleen L. Schneider, Sarah Mohajeri-Moghaddam, Esau G. Mbewe, Pelekelo P. Kabundula, Owen Dean, Alexandra Buda, Michael J. Potchen, Sylvia Mwanza-Kabaghe, Deanna Saylor, Heather R. Adams, Gretchen L. Birbeck, David R. Bearden Tags: Research Paper Source Type: research

COVID-19 Infection Presenting as Acute Onset Focal Status Epilepticus
Documented cases of neurological complications in patients with SARS-CoV-2 are accumulating. Status epilepticus and encephalopathy has now been reported as a presenting symptom in adults and children with COVID-19.1,2 Our team admitted a nine year old boy with no medical history following an episode of focal status epilepticus and encephalopathy. He was afebrile and without signs of meningismus at the time of admission. One milligram of lorazepam IV terminated his symptoms with rapid return to baseline mental status. (Source: Pediatric Neurology)
Source: Pediatric Neurology - July 30, 2020 Category: Neurology Authors: Jeffrey A. Swarz, Sarah Daily, Emily Niemi, Samuel G. Hilbert, Hala Ali Ibrahim, John N. Gaitanis Tags: Correspondence Source Type: research

Epilepsy Risk Prediction Model for Patients with Tuberous Sclerosis Complex
Individuals with tuberous sclerosis complex (TSC) are at increased risk of epilepsy. Early seizure control improves developmental outcomes, making identifying at-risk patients critically important. Despite several identified risk factors, it remains difficult to predict. The purpose of the study was to confirm previously identified risk factors for epilepsy in patients with TSC and evaluate the combined risk prediction of these factors. (Source: Pediatric Neurology)
Source: Pediatric Neurology - July 28, 2020 Category: Neurology Authors: Laura S. Farach, Melissa A. Richard, Philip J. Lupo, Mustafa Sahin, Darcy A. Krueger, Joyce Y. Wu, Elizabeth M. Bebin, Kit Sing Au, Hope Northrup, TACERN Study Group Tags: Research Paper Source Type: research

Transverse myelitis in a child with Covid-19
We report a case of longitudinally extensive transverse myelitis (LETM) in a previously healthy three-year-old Navajo girl with novel coronavirus (SARS-CoV-2) infection, who was asymptomatic prior to onset of weakness. (Source: Pediatric Neurology)
Source: Pediatric Neurology - July 28, 2020 Category: Neurology Authors: Harsheen Kaur, John Alan Mason, Manish Bajracharya, John McGee, Matthew D. Gunderson, Blaine L. Hart, Walter Dehority, Nathaniel Link, Brian Moore, John P. Phillips, Danny Rogers Tags: Short Communication Source Type: research

The phenotypic spectrum of PNKP-associated disease and the absence of immunodeficiency and cancer predisposition in a Dutch cohort.
To expand the number of currently known pathogenic PNKP mutations, to study the phenotypic spectrum including radiological characteristics, genotype-phenotype correlations, and assess whether immunodeficiency and increased cancer risk are part of the DNA repair disorder caused by mutations in the PNKP gene. (Source: Pediatric Neurology)
Source: Pediatric Neurology - July 28, 2020 Category: Neurology Authors: Mark R. Garrelfs, Sanami Takada, Erik-Jan Kamsteeg, Sjoerd Pegge, Grazia Mancini, Marc Engelen, Bart van de Warrenburg, Alexander Rennings, Judith van Gaalen, Ivo Peters, Corry Weemaes, Mirjam van der Burg, Mich èl A. Willemsen Tags: Research Paper Source Type: research

Apparent radiological improvement in an infant with Labrune syndrome treated with bevacizumab
Leukoencephalopathy with intracranial calcification and cysts (LCC) is a rare genetic disorder characterized by progressive cerebral degeneration, seizures, and a mixture of extrapyramidal, pyramidal and cerebellar signs.1,2 LCC is associated with mutations in the small nucleolar RNA, C/D box 118 gene (SNORD118) inherited as an autosomal recessive trait.3 To date, 59 patients have been described with biallelic mutations in this gene. LCC has no known treatment, however, the use of the VEGF-blocker bevacizumab has been described in a single case, apparently associated with an improvement in clinical and radiological feature...
Source: Pediatric Neurology - July 25, 2020 Category: Neurology Authors: M. Mart ínez-Matilla, J.J. Ferre-Fernández, M.J. Aparisi, A.V. Marco-Hernández, J.A. Cerón, Y.J. Crow, F. Martínez-Castellano, M. Tomás-Vila, L. Pedrola Tags: Short Communication Source Type: research

Editorial Board and Masthead
(Source: Pediatric Neurology)
Source: Pediatric Neurology - July 23, 2020 Category: Neurology Source Type: research

Table of Contents
(Source: Pediatric Neurology)
Source: Pediatric Neurology - July 23, 2020 Category: Neurology Source Type: research

RE: Clinical and Molecular Diagnosis of Joubert Syndrome and Related Disorders
Sir, (Source: Pediatric Neurology)
Source: Pediatric Neurology - July 23, 2020 Category: Neurology Authors: Miguel Barroso-Gil, Laura Powell, John A. Sayer Tags: Correspondence Source Type: research

Reply
We thank Drs. Trabacca and Russo for their reflection and comments about childhood disability and the ethics of care during the exceptional circumstances of a viral pandemic.(1) We recognize the many social, educational, environmental, and health care disruptions that COVID-19 has imposed on the routines of all children. Such disruptions are often disproportionately stressful to the families of children with neurodevelopmental and neuromuscular disabilities, whose “non-essential” community-based support services are restricted because of the imperatives of physical distancing. (Source: Pediatric Neurology)
Source: Pediatric Neurology - July 21, 2020 Category: Neurology Authors: William D. Graf, Leon G. Epstein, Phillip L. Pearl Tags: Correspondence Source Type: research

Intravenous nimodipine treatment for severe episode of ATP1A2 hemiplegic migraine
We report for the first time a successful treatment of a prolonged Na+-K+-ATPase subunit gene ATP1A2 -linked HM attack in a pediatric case with the calcium antagonist nimodipine. Nimodipine treatment is currently established only for management of HM involving calcium channels. (Source: Pediatric Neurology)
Source: Pediatric Neurology - July 21, 2020 Category: Neurology Authors: Fabian Dannenberg, Christine Prager, Florian Schmidt, Anna Tietze, Petra Bittigau, Angela M. Kaindl Tags: Short Communication Source Type: research

Risk factors for readmissions of children with epilepsy
Dear Editor (Source: Pediatric Neurology)
Source: Pediatric Neurology - July 18, 2020 Category: Neurology Authors: Prateek Kumar Panda, Indar Kumar Sharawat Tags: Letter from the Editor Source Type: research

Immunoassays disruption by high dose biotin therapy: fair warning for neonatal care pediatricians
Clinical Letter (Source: Pediatric Neurology)
Source: Pediatric Neurology - July 14, 2020 Category: Neurology Authors: Charles R. Lefevre, Lucas Peltier, L éna Damaj, Jessica Valaize, Claude Bendavid, Caroline Moreau Tags: Short Communication Source Type: research

Bradycardia - a rare but significant side effect of oral steroids in patients with epileptic spasms
Oral corticosteroids have recently emerged as an alternative treatment option for epileptic spasms [1,2]. Some of steroids ’ side effects are well known. Less common side effects include cardiac arrhythmias, and even less common is sinus bradycardia. Herein we report two patients who developed sinus bradycardia within a week of starting prednisolone for epileptic spasms, an abnormality that resolved when the medicatio n was discontinued. (Source: Pediatric Neurology)
Source: Pediatric Neurology - July 7, 2020 Category: Neurology Authors: Sonal Sharma, Sherouk Abdelmoity, Mohammed Ilyas Tags: Short Communication Source Type: research

The Utilization of Nerve Transfer for Reestablishing Shoulder Function in the Setting of Acute Flaccid Myelitis: A Single Institution Review
Acute flaccid myelitis (AFM) is rare and devastating disease of young children. Although the etiology of this disease remains unknown, the typical presentation involves acute onset flaccid paralysis in one or more extremities with a nonspecific prodrome that may resemble a self-limited upper respiratory tract infection. Treatment for this illness is largely supportive and long-term functional outcomes demonstrate that muscle group recovery plateaus around 6 to 9 months and is often incomplete, leaving patients with considerable long-term deficits. (Source: Pediatric Neurology)
Source: Pediatric Neurology - July 7, 2020 Category: Neurology Authors: Taylor M. Paziuk, Madeline Tadley, Michael Aversano, Scott H. Kozin, Dan A. Zlotolow Tags: Original Articles Source Type: research

Confirming Pediatric Brain Death in a Resource-Limited Settings: Lessons and Challenges
Evaluating and managing children suspected of brain death in resource limited settings is uncommon. However, as access to critical care increases globally, more practitioners will encounter this difficult clinical scenario. Challenges surrounding brain death in this setting are numerous including the lack of a globally accepted definition and formal declaration guidelines, insufficient resources and limited training to evaluate for brain death. The ethical concerns are paramount; balancing culturally acceptable beliefs with best management and allocation of resources. (Source: Pediatric Neurology)
Source: Pediatric Neurology - July 6, 2020 Category: Neurology Authors: G. Wooldridge, Y. Fonseca Tags: Opinion Paper Source Type: research

Rituximab as Adjunct Maintenance Therapy for Refractory Juvenile Myasthenia Gravis
The objective of our study was to assess the tolerability and efficacy of rituximab use in children with refractory JMG. (Source: Pediatric Neurology)
Source: Pediatric Neurology - July 6, 2020 Category: Neurology Authors: Carla D. Zingariello, Melissa E. Elder, Peter B. Kang Tags: Short Communication Source Type: research

Clinical therapeutic management of human mitochondrial disorders
Despite recent advances in the elucidation of etiology and pathogenesis of mitochondrial disorders (MIDs), their therapeutic management remains challenging. This review focuses on currently available therapeutic options for human MIDs.Current treatment of MIDs relies on symptomatic, multidisciplinary therapies of various manifestations in organs such as the brain, muscle, nerves, eyes, ears, endocrine organs, heart, intestines, kidneys, lungs, bones, bone-marrow, cartilage, immune-system, and skin. (Source: Pediatric Neurology)
Source: Pediatric Neurology - July 6, 2020 Category: Neurology Authors: Josef Finsterer Tags: Review Article Source Type: research

Secondary Intracranial Hypertension in Pediatric Patients with Cryopyrin-Associated Periodic Syndrome
We present our series of patients with CAPS that clinically met the diagnostic criteria for Muckle-Wells syndrome and our experience with secondary intracranial hypertension (SIH). (Source: Pediatric Neurology)
Source: Pediatric Neurology - July 3, 2020 Category: Neurology Authors: David L. Rogers, Shoghik Akoghlanian, Rachel E. Reem, Sage Rogers, Shawn C. Aylward Tags: Short Communication Source Type: research

CAR-T cell Therapy Related Neurotoxicity in Pediatric Acute Lymphoblastic Leukaemia (ALL): Spectrum of Imaging Findings
The emergence of CD19-targeted chimeric antigen receptor-T (CAR-T) cell therapy has created a new era in the management of pediatric patients with refractory B-cell malignancies such as B-cell acute lymphoblastic leukaemia (ALL). Immune effector cell-associated neurotoxicity syndrome (ICANS) is frequently encountered in the post infusion period of CD19-targeted CAR-T cell therapy and in some cases may be fatal. Knowledge related to the spectrum of imaging findings of CD19-targeted CAR-T cell therapy-related ICANS is however still very much lacking, underscoring the need for continued research in this area. (Source: Pediatric Neurology)
Source: Pediatric Neurology - July 2, 2020 Category: Neurology Authors: Ai Peng Tan; Tags: Review Article Source Type: research

Use of Nimodipine in a neonate with cerebral vasospasm with delayed ischemia from subarachnoid hemorrhage in the posterior fossa
We describe the use of nimodipine in a neonate with SAH resulting in vasospasm and DCI. (Source: Pediatric Neurology)
Source: Pediatric Neurology - July 2, 2020 Category: Neurology Authors: Bridget McGowan, Gurpreet Khaira, Meghan A. Coghlan, Ali Shaibani, Tord D. Alden, Andrea C. Pardo Tags: Short Communication Source Type: research

The American Neurological Association ’s book ‘Eugenical Sterilization: A Reorientation of the Problem’ through the lens of contemporaneous book reviews.
To investigate the opinion of the American Neurological Association ’s (ANA) book “Eugenical Sterilization: A Reorientation of the Problem” through the lens of contemporaneous book reviews. (Source: Pediatric Neurology)
Source: Pediatric Neurology - July 2, 2020 Category: Neurology Authors: Pedro Weisleder Tags: Original Articles Source Type: research

Zonisamide therapy for patients with paroxysmal kinesigenic dyskinesia
We aimed to evaluate zonisamide therapy in patients with paroxysmal kinesigenic dyskinesia (PKD). (Source: Pediatric Neurology)
Source: Pediatric Neurology - June 30, 2020 Category: Neurology Authors: Ryuki Matsuura, Shin-ichiro Hamano, Erika Hiwatari, Satoru Ikemoto, Yuko Hirata, Reiko Koichihara, Kenjiro Kikuchi Tags: Research Paper Source Type: research

Syndromic autism revisited: review of the literature and lessons learned
Autism spectrum disorder is a neurodevelopmental disorder characterized by deficits in communication, stereotyped behaviors, restricted interests, and impaired social skills. The severity of the neurobehavioral phenotype is variable, and historically has been distinguished based on the presence or absence of additional symptoms, termed syndromic and nonsyndromic or idiopathic autism, respectively. However, while the advancement in genetic molecular technologies has brought an increased understanding of the pathophysiology of autism, the majority of this success has been in the diagnosis of syndromic disease, while the etio...
Source: Pediatric Neurology - June 28, 2020 Category: Neurology Authors: Catherine A. Ziats, Wesley G. Patterson, Michael Friez Tags: Review Article Source Type: research

Characterization of Severe and Extreme Behavioral Problems in Patients with Alternating Hemiplegia of Childhood
Alternating Hemiplegia of Childhood (AHC) often manifests severe or extreme behavioral problems, the nature of which remain to be fully characterized. (Source: Pediatric Neurology)
Source: Pediatric Neurology - June 27, 2020 Category: Neurology Authors: Keri Wallace, Julie Uchitel, Lyndsey Prange, Joan Jasien, Melanie Bonner, Richard D ’Alli, Gary Maslow, Mohamad A. Mikati Tags: Research Paper Source Type: research

ACTH treatment of infantile spasms: Low-moderate vs high dose, natural vs synthetic ACTH. A retrospective study
High dosages of natural adrenocorticotropic hormone (ACTH) are used in many centers in the U.S. for the treatment of infantile spasms (IS). However, lower dosages of synthetic ACTH (tetracosactide) might be equally as efficient as high dosages. (Source: Pediatric Neurology)
Source: Pediatric Neurology - June 26, 2020 Category: Neurology Authors: Raili Riikonen, Jaana L ähdetie, Hannu Kokki Tags: Research Paper Source Type: research

The Presurgical Evaluation of Drug Resistant Epilepsy
Anti-epileptic drugs have afforded good seizure control to approximately 70% of individuals with epilepsy. Epilepsy surgery, for appropriate candidates, could be extremely beneficial to those with drug resistance. Trephination is a crude and invasive approach to managing epilepsy and has occurred since antiquity. The late 1800 ’s saw the advent of a more evidence-based approach with attempts to define seizure foci as well as determine areas of function. This largely required direct stimulation during surgery prior to resection. (Source: Pediatric Neurology)
Source: Pediatric Neurology - June 26, 2020 Category: Neurology Authors: D.F. Clarke, E.G. Shah, F.F. Perkins Tags: Opinion Paper Source Type: research

ACTH treatment of infantile spasms: Low-moderate vs. high dose, natural vs. synthetic ACTH. A retrospective cohort study
High dosages of natural adrenocorticotropic hormone (ACTH) are used in many centers in the U.S. for the treatment of infantile spasms (IS). However, lower dosages of synthetic ACTH (tetracosactide) might be equally as efficient as high dosages. (Source: Pediatric Neurology)
Source: Pediatric Neurology - June 26, 2020 Category: Neurology Authors: Raili Riikonen, Jaana L ähdetie, Hannu Kokki Tags: Research Paper Source Type: research

Fear and Understanding in the Time of COVID-19
Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we may fear less. (Source: Pediatric Neurology)
Source: Pediatric Neurology - June 26, 2020 Category: Neurology Authors: Steven Pavlakis, Gary McAbee, E. Steve Roach Tags: Perspectives in Pediatric Neurology Source Type: research

Change of white matter integrity in children with hematopoietic stem cell transplantation
Advances of hematopoietic stem cell transplantation has improved the survival rate of malignant diseases and congenital immunodeficiencies. It has become important to assess long-term complications in survivors. To assess CNS abnormalities in children treated by transplantation, diffusion tensor imaging (DTI) was performed before and after transplantation. (Source: Pediatric Neurology)
Source: Pediatric Neurology - June 24, 2020 Category: Neurology Authors: Yoko Sakaguchi, Jun Natsume, Hiroyuki Kidokoro, Masaharu Tanaka, Yu Okai, Yuji Ito, Hiroyuki Yamamoto, Atsuko Ohno, Tomohiko Nakata, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka, Hideki Muramatsu, Shinji Naganawa, Yoshiyuki Takahashi Tags: Research Paper Source Type: research

Trainee award announcement
The COVID-19 pandemic and the increased awareness surrounding racial injustice has challenged us to find new ways to help children and young adults with neurologic illness while also improving access to care for all. Recognizing and supporting talented trainees to lead the next generation of clinical pediatric neuroscientists is essential. Please join the journal ’s Trainee Award Selection Committee and the editors in congratulating Gracia De Jong, MD (Fig) from the Detroit Medical Center Children’s Hospital of Michigan, the recipient of the 2019 Pediatric Neurology Trainee Publication Award for her publication...
Source: Pediatric Neurology - June 24, 2020 Category: Neurology Authors: Yasmin Khakoo, J. Nicholas Brenton, John R. Mytinger, James J. Reese, Morris H. Scantlebury Tags: Editorial Source Type: research

WITHDRAWN: Commentary: What matters most? Outcome measures in Rett syndrome
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause.The full Elsevier Policy on Article Withdrawal can be found athttps://www.elsevier.com/about/our-business/policies/article-withdrawal (Source: Pediatric Neurology)
Source: Pediatric Neurology - June 20, 2020 Category: Neurology Authors: Brittany Mann Source Type: research

Commentary: What matters most? Outcome measures in Rett syndrome
In the face of clinical and ethical obligations to improve quality of life for individuals with Rett syndrome (RTT), much research remains focused on functional impairments, despite RTT-specific domains of quality of life having recently been identified (12). The recent study by (5) critiques the design of the Rett Syndrome Behavioural Questionnaire (RSBQ) (8), its items, scales, domains and how these relate to clinical presentations of patients. The commentary in response from (9) is a critique of the sample used by (5) in their justification of refuting the RSBQ. (Source: Pediatric Neurology)
Source: Pediatric Neurology - June 20, 2020 Category: Neurology Authors: Brittany Mann Tags: Opinion Paper Source Type: research

Delayed Diagnosis of Anti-Hu Antibodies in a Young Patient with Cerebellar Atrophy
We report a patient with pronounced cerebellar syndrome mediated by anti-HU antibodies with several years of diagnostic delay. (Source: Pediatric Neurology)
Source: Pediatric Neurology - June 19, 2020 Category: Neurology Authors: Daniel Richter, Tobias Hegelmaier, Christiane Schneider-Gold, Ralf Gold, Simon Faissner Tags: Short Communication Source Type: research

Editorial Board and Masthead
(Source: Pediatric Neurology)
Source: Pediatric Neurology - June 17, 2020 Category: Neurology Source Type: research

Table of Contents
(Source: Pediatric Neurology)
Source: Pediatric Neurology - June 17, 2020 Category: Neurology Source Type: research

Meetings of Interest
(Source: Pediatric Neurology)
Source: Pediatric Neurology - June 17, 2020 Category: Neurology Source Type: research

Elevated Leukodystrophy Incidence Predicted From Genomics Databases
Leukodystrophies are genetic diseases affecting the white matter and leading to early death. Our objective was to determine leukodystrophy incidence, using genomics sequencing databases allele frequencies of disease-causing variants. (Source: Pediatric Neurology)
Source: Pediatric Neurology - June 17, 2020 Category: Neurology Authors: Haille E. Soderholm, Alexander B. Chapin, Pinar Bayrak-Toydemir, Joshua L. Bonkowsky Tags: Original Articles Source Type: research

The ethic of care, disability and rehabilitation during the covid-19 pandemic
With great interest did we read the editorial by William D. Graph et al. on Practical Bioethics during the Exceptional Circumstances of a Pandemic[1] which prompted deep reflection on ethics of care, disability (specifically childhood disability) and rehabilitation in a global context where the novel COVID-19 emergency is the biggest challenge for human rights and a challenge for healthcare systems. The outbreak of COVID-19 and its propagation have in themselves the characteristics of potentially traumatic events.[2] While response to stressful events undoubtedly depends on several subjective variables, the more an event i...
Source: Pediatric Neurology - June 15, 2020 Category: Neurology Authors: Luigi Russo, Antonio Trabacca Tags: Correspondence Source Type: research

Cognitive and Emotional Functioning in Pediatric Migraine Relative to Healthy Controls
Chronic migraine (CM) refers to headaches occurring on 15 or more days per month over a 3-month period, with at least 8 of those days involving migraines. CM commonly co-occurs with psychological disorders, especially depression and anxiety. It has also been shown to disrupt some cognitive processes (e.g., attention, memory) in adults. However, fewer studies have examined cognitive functioning in children with CM. We investigated whether children with CM differ from healthy controls in memory, attention, and depression. (Source: Pediatric Neurology)
Source: Pediatric Neurology - June 11, 2020 Category: Neurology Authors: Gabriel C. Araujo, Jonathan N. Dodd, Soe Mar Tags: Research Paper Source Type: research

The Curious Case of the Fast Feelers: A Reflection on Alice in Wonderland Syndrome
About a month ago, a reddit page called “Fast Feeling” was brought to my attention by my cousin, who said that he found it while looking up certain unusual symptoms he had experienced. I read with fascination and great curiosity as person after person in that group (consisting of over a thousand members) described a very coherent set of symptoms they all shared, and which they had termed “fast feeling.” I had never encountered or heard of anything like it before; these “fast feeling” episodes had two main characteristics: 1- time and body movements feel sped up (as though everything was ...
Source: Pediatric Neurology - June 11, 2020 Category: Neurology Authors: Mario K. Shammas Tags: Opinion Paper Source Type: research

Cancer and Tumor-Associated Childhood Stroke: Results from the International Pediatric Stroke Study
This study sought to evaluate cancer/tumor-associated childhood ischemic stroke in a multinational pediatric stroke registry. (Source: Pediatric Neurology)
Source: Pediatric Neurology - June 9, 2020 Category: Neurology Authors: Lisa R. Sun, Alexandra Linds, Mukta Sharma, Mubeen Rafay, Sudhakar Vadivelu, Sarah Lee, Leonardo R. Brand ão, Brian Appavu, Jeremie H. Estepp, Juliette Hukin, Sahar M.A. Hassanein, Anthony Chan, Lauren A. Beslow, International Pediatric Stroke Study Grou Tags: Research Paper Source Type: research

Ocular motor paroxysmal events in neonates and infants: a review of the literature
Ocular Paroxysmal Events (OPEs) can accompany a variety of neurological disorders. Particularly in infants, OPEs often present a great diagnostic challenge for pediatric neurologists and neonatologists. Distinguishing between epileptic and non-epileptic events, or physiological and pathological paroxysmal events can be challenging at this age, since clinical history and physical examination are often limited. Continuous polygraphic video-EEG monitoring can be very helpful in these situations. (Source: Pediatric Neurology)
Source: Pediatric Neurology - June 7, 2020 Category: Neurology Authors: Raffaele Falsaperla, Marco Andrea Nicola Saporito, Francesco Pisani, Janette Mailo, Piero Pavone, Martino Ruggieri, Agnese Suppiej, Giovanni Corsello Tags: Review Article Source Type: research

Assessing and Enhancing Clinical Competence: The 2019 Hower Award Lecture.
Medical education can be considered a linear process, beginning with four years of an undergraduate education followed by four years of medical school and three to seven or more years of post-graduate training. This linear process, a colleague once noted, makes neurologists superb educators because we think linearly. As an example, a child has a seizure, and we logically proceed to a routine awake and asleep electroencephalogram (EEG). If the EEG is normal, we observe the child, whereas if the EEG is abnormal, we may consider anticonvulsant therapy, depending upon the nature of the EEG findings and the clinical characteris...
Source: Pediatric Neurology - June 7, 2020 Category: Neurology Authors: James F. Bale Tags: Opinion Paper Source Type: research

Allocating Medical Resources During a Mass Casualty Emergency: Sometimes It Is OK to Wait
The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2 or COVID-19) pandemic has overwhelmed health care systems the world over, turning the situation into a “mass casualty emergency” (MCE) in some locations. Ideally, medical resources—material and human—would be unlimited. However, as the current pandemic has made evident, such thinking is utopian—shortages and rationing are here.1 As such, health care providers have a duty to prepare to make critical allocation choices with life-and-death consequences. (Source: Pediatric Neurology)
Source: Pediatric Neurology - June 6, 2020 Category: Neurology Authors: Pedro Weisleder, Jorge Vidaurre Tags: Opinion Paper Source Type: research

Psychogenic Gait Disorder Complicating Recovery after Concussion: A Case Series
This report is an initial description of psychogenic (functional) gait complicating recovery after concussion in a group of adolescents. (Source: Pediatric Neurology)
Source: Pediatric Neurology - June 6, 2020 Category: Neurology Authors: Scott I. Otallah Tags: Short Communication Source Type: research

Allocating medical resources during a mass casualty emergency: sometimes, ‘it’s OK to wait.’
The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2 or COVID-19), pandemic has overwhelmed healthcare systems the-world-over, turning the situation into a ‘mass casualty emergency’ (MCE). Ideally, medical resources – material and human – would be unlimited. But as the current pandemic has made evident, such thinking is utopian – shortages and rationing are here.(1) As such, healthcare providers have a duty to prepare to make critical allocat ion choices with life-and-death consequences.(1,2) (Source: Pediatric Neurology)
Source: Pediatric Neurology - June 6, 2020 Category: Neurology Authors: Pedro Weisleder, Jorge Vidaurre Tags: Opinion Paper Source Type: research

Central Apnea in an Adolescent With COVID-19
We describe a pediatric girl with COVID-19 –associated encephalopathy characterized by focal seizures and central apnea. (Source: Pediatric Neurology)
Source: Pediatric Neurology - June 4, 2020 Category: Neurology Authors: Stephanie Enner, Sanaya Hormozdyaran, Robin Varughese, Jennifer Milillo, Ivan Pavkovic, Emma Laureta, James Schneider, Sanjeev Kothare Tags: Clinical Letter Source Type: research