The Genetic Epidemiology of Pediatric Pulmonary Arterial Hypertension
To describe the prevalence of pulmonary arterial hypertension (PAH)-associated gene mutations, and other genetic characteristics in a national cohort of children with PAH from the Dutch National registry and to explore genotype-phenotype associations and outcomes. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 2, 2020 Category: Pediatrics Authors: Meindina G. Haarman, Wilhelmina S. Kerstjens-Frederikse, Theresia R. Vissia-Kazemier, Karel T.N. Breeman, Wim Timens, Yvonne J. Vos, Marc T.R. Roofthooft, Hans L. Hillege, Rolf M.F. Berger Tags: Original Articles Source Type: research

Clinical and Genetic Spectrum of Children with Primary Ciliary Dyskinesia in China
To report detailed knowledge about the clinical manifestations, ciliary phenotypes, genetic spectrum as well as phenotype/genotype correlation in primary ciliary dyskinesia (PCD) in Chinese children. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 2, 2020 Category: Pediatrics Authors: Zhuoyao Guo, Weicheng Chen, Libo Wang, Liling Qian Tags: Original Articles Source Type: research

Resistin/Uric Acid Index for Weight Loss Prediction?
I read with interest the report by Zurita-Cruz concerning the utilization of a resistin/uric acid index as a prognostic marker for BMI reduction1. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 2, 2020 Category: Pediatrics Authors: Rhys Dore Tags: Letters to the Editor Source Type: research

Reply
We appreciate Dr Dore ’s comments regarding our study on the usefulness of the resistin / uric acid index to predict weight loss in adolescents with overweight or obesity. 2 (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 2, 2020 Category: Pediatrics Authors: Miguel Villas ís-Keever, Jessie Zurita Cruz Tags: Letters to the Editor Source Type: research

Duodenal Atresia with Bifid Common Bile Duct
A female infant carried a late pre-natal diagnosis of duodenal atresia that was detected via ultrasound at 38 weeks showing a dilated fetal stomach. The patient was born to an otherwise healthy primagravid mother with a history of Hashimoto ’s hypothyroism treated with daily synthroid. The pregnancy and subsequent delivery were uncomplicated, and prior amniocentesis found a 46XX karyotype. At birth, the patient had an abdominal x-ray that showed a distended stomach. The remainder of the abdomen was gasless. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 2, 2020 Category: Pediatrics Authors: Cornelia Griggs, Carrie Ruzal-Shapiro, Erica Fallon Tags: Insights and Images Source Type: research

Late presentation of Long Segment Tracheal Stenosis with Complete Tracheal Rings
The views expressed in this abstract/manuscript are those of the author(s) and do not reflect the official policy or position of the Department of the Army, Department of Defense, or the US Government. The authors declare no conflicts of interest. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 1, 2020 Category: Pediatrics Authors: Mark C. Spaw, Bryan J. Liming, Christine M. Gould Tags: Insights and Images Source Type: research

Changes in Routine Pediatric Practice in Light of COVID-19
The outbreak of SARS-CoV-2 or COVID-19,1 in the city of Wuhan, China in December 2019 has rapidly emerged into a pandemic affecting national communities throughout the world.2 As of 17 May 2020, over 4.5 million people have been infected globally at a pace of 100,000/day, and 307.395 have died.3 We will briefly discuss the effects of COVID-19 on routine pediatric practice, which have surfaced during the months after the onset of the pandemic and the implications for children ’s health. Our aim is to raise awareness about the likely need to remodel routine pediatric practice, both in hospital and ambulatory services, ...
Source: The Journal of Pediatrics - June 1, 2020 Category: Pediatrics Authors: Ido Somekh, Raz Somech, Massimo Pettoello-Mantovani, Eli Somekh Source Type: research

Mind the Gap
Prior to 1972, pediatricians generally relinquished THE CARE OF teenage patients to adult providers. That year, a forward thinking American Academy of Pediatrics (AAP) Section on Child Health redefined pediatric care to encompass birth through age 21 years. Dedication to longitudinal care for teens and young adults was sealed through creation of certification in Adolescent Medicine through the American Board of Pediatrics (ABP) in 1991. Decades later, it is clear that our AAP and ABP leaders were prescient in this approach. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 31, 2020 Category: Pediatrics Authors: Morissa J. Ladinsky, Mitchell B. Cohen Tags: Editorials Source Type: research

Foreword: Current Topics in Pediatric Translational Research
Until recently, the care of children has almost entirely been based on adult evidence. Even today, many treatments used in pediatric clinical care remain off-label. Although research that is focused on the most vulnerable population —children—continues to receive only a small proportion of all grant funding for health science research in countries/regions such as the US, Canada, Europe, Australia, and others, great strides have been made through progressively more stringent requirements by regulatory agencies, as well as th rough the efforts of advocacy groups, professional organizations, and subspecialty socie...
Source: The Journal of Pediatrics - May 29, 2020 Category: Pediatrics Authors: Neil A. Goldenberg, Vera Ignjatovic Tags: Supplement Source Type: research

Beyond Biobanking: Future Use of Specimens and Data from Pediatric Participants
For more than a decade, researchers and ethicists have grappled with issues of parental permission, assent, return of results, and models of governance for pediatric biobanks.1-4 Although these evaluations have made important contributions to conversations regarding the design and management of pediatric biobanks, they fail to address the fact that most future uses of biospecimens and associated data collected from children may not actually fall within the biobanking framework. Plans for future use of data and biospecimens have now become a core component and expectation for all research. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 29, 2020 Category: Pediatrics Authors: Megan Kasimatis Singleton, Margaret Moon, E. Verena Jorgensen Tags: Supplement Source Type: research

The Human Breast Milk Metabolome in Preeclampsia, Gestational Diabetes, and Intrauterine Growth Restriction: Implications for Child Growth and Development
Three complications of pregnancy —preeclampsia, gestational diabetes mellitus, and intrauterine growth restriction (IUGR)—are thought to share a common etiology, in which abnormal placental development and the resulting maternal inflammatory response play a key role.1 These 3 conditions, known as great obstetrical syndromes, ar e unfortunately quite common in pregnancy. However, the field of metabolomics has provided a rapid approach in identifying biomarkers predictive of their outcome.2,3 (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 29, 2020 Category: Pediatrics Authors: Flaminia Bardanzellu, Melania Puddu, Vassilios Fanos Tags: Supplement Source Type: research

Plasma Proteomic Analysis Reveals Age-Specific Changes in Platelet- and Endothelial Cell –Derived Proteins and Regulators of Plasma Coagulation and Fibrinolysis
This post hoc study of a plasma proteomic database investigated hemostatic proteins in the context of developmental hemostasis. Twenty-seven hemostatic proteins changed expression with age, and the hemostatic profile of neonates was unique. Appreciating developmental hemostasis through proteomics may lead to more personalized medicine for hospitalized children. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 29, 2020 Category: Pediatrics Authors: Conor McCafferty, Xavier Busuttil-Crellin, Tengyi Cai, Paul Monagle, Neil A. Goldenberg, Vera Ignjatovic Tags: Supplement Source Type: research

Research Engagement in Pediatric Nursing Practice: Career Pathways are the Biggest Barrier
We explored professional pathways for research prepared nurses seeking to develop clinical research careers. We postulated the paucity of such pathways was the biggest barrier to research prepared nurses having the opportunity to demonstrate value add of their academic training to clinical practice and patient outcomes. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 29, 2020 Category: Pediatrics Authors: Fiona Newall, Kate Khair Tags: Supplement Source Type: research

Structural Connectomics: State of the Art and Applications in Pediatric Neurodevelopmental Disorders, Neuro-Oncology, and Arterial Ischemic Stroke
The human connectome reflects the agenda for the new era of brain networks.1 The connectome represents the structural and functional layout of brain networks and often is represented as a mathematical grid.2-4 Brain network graphs provide a simplified view of the human brain connectome, using graph theory to abstractly define the brain as a set of anatomical regions (or “nodes”) and structural connections (called “edges”).4,5 (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 29, 2020 Category: Pediatrics Authors: Avner Meoded, Neil A. Goldenberg, Thierry A.G. M. Huisman Tags: Supplement Source Type: research

Enhancing Collaboration between Clinician-Researchers and Methodologists in Clinical Research
Recent concerns about the reproducibility of scientific research emphasize the need for research to be conducted in a methodologically rigorous manner using robust designs and the application of appropriate statistical methods.1-3 Clinical research may be initiated by clinician-researchers who identify research ideas and then seek collaborators with methodologic expertise to conduct the study. Some clinician-researchers have undergone graduate training, have experience in quantitative methods, and can lead the design and conduct of clinical studies using accepted scientific principles and methods. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 29, 2020 Category: Pediatrics Authors: Joseph Amuah, Donatus R. Mutasingwa, Ernest K. Amankwah Tags: Supplement Source Type: research

Machine Learning and Artificial Intelligence in Pediatric Research: Current State, Future Prospects, and Examples in Perioperative and Critical Care
Machine learning is increasingly used to analyze information generated by electronic health record systems and other large public health datasets.1,2 It is a field of artificial intelligence that uses pattern recognition and computer modeling to uncover complex nonlinear relationships existing among independent and dependent variables. Machine learning can be thought of as the next level from logistic or linear regression analysis in the continuum of statistics.3 The techniques of machine learning are more suitable for analysis of complex medical problems than standard statistics as they can discover nonlinearities in the ...
Source: The Journal of Pediatrics - May 29, 2020 Category: Pediatrics Authors: Hannah Lonsdale, Ali Jalali, Luis Ahumada, Clyde Matava Tags: Supplement Source Type: research

The “Federated Pediatric BioCloud” Model: State of the Art and Future Prospects in Pediatric Biospecimen Science
Systematic collection, storage of, and access to high-quality biospecimens representative of the various stages of disease remains a great challenge. This remains the case notwithstanding the identification of key issues effecting systemization of tissue handling activity for research using hospital sample archives or siloed institutional biobanks.1 According to a survey study conducted among US biorepositories in 2013, 44% reported storing biospecimens from children 18  years or under, but only 2% focused solely on the biobanking of pediatric specimens. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 29, 2020 Category: Pediatrics Authors: William S. Schleif, Neil A. Goldenberg, Daniel R. Catchpoole Tags: Supplement Source Type: research

Operationalizing Good Clinical Practice Principles in Pediatric Clinical Research
We describe our institution's approach to educating clinical investigators regarding the International Council for Harmonisation's good clinical practice guidelines by emphasizing how to operationalize these principles into day-to-day practice in a pediatric setting. We highlight the importance of aligning organizational policies, standard operating procedures (SOPs), and work practice tools to good clinical practice principles throughout each phase of the clinical research study lifecycle. We further describe how this approach to good clinical practice education —including interactive sessions and pediatric-specific...
Source: The Journal of Pediatrics - May 29, 2020 Category: Pediatrics Authors: Heather Cronin, Frances Hamblin, Neil A. Goldenberg Tags: Supplement Source Type: research

The Emerging Field of Noncoding RNAs and Their Importance  in Pediatric Diseases
Dr Barton Childs' landmark 1999 text, Genetic Medicine – A Logic of Disease, led to the development of a new curriculum at Johns Hopkins School of Medicine entitled “Genes to Society.”1 A core part of contemporary medical school and pediatric residency training is individualized medicine. Trainees are now being equipped for an era of personalized, “precision” medicine. Childs said that, in the next century, medicine will be focused on the treatment of individuals rather than disease. This raises the question of how different are individuals at the genomic level? Early after the discovery of th...
Source: The Journal of Pediatrics - May 29, 2020 Category: Pediatrics Authors: Rui Zhou, Piyush Joshi, Keisuke Katsushima, Weihong Liang, Wei Liu, Neil A. Goldenberg, George Dover, Ranjan J. Perera Tags: Supplement Source Type: research

Supplement Title Page
(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 29, 2020 Category: Pediatrics Source Type: research

Guidelines for Supplement
(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 29, 2020 Category: Pediatrics Source Type: research

Contents
(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 29, 2020 Category: Pediatrics Source Type: research

Gaps Exist in the Comprehensive Care of Children with Inflammatory Bowel  Diseases
To describe patterns of primary and specialty care delivery in pediatric patients with inflammatory bowel diseases (IBD), delineate which members of the healthcare team provided services, and identify gaps in care. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 29, 2020 Category: Pediatrics Authors: Hilary K. Michel, Sandra C. Kim, Nalyn Siripong, Robert B. Noll Tags: Original Articles Source Type: research

The Use of Statistical Learning in Pediatric Research
In a recent study published in The Journal of Pediatrics, Scott et  al1 reported findings from an analysis that described the development and validation of a prediction model that detects septic shock in children by leveraging routine electronic health record data. The prediction model described in the authors' analysis predicts the probability of a pediatric pat ient with suspected sepsis experiencing septic shock during their medical encounter in urgent care, thereby increasing the chance of early detection and survival. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 29, 2020 Category: Pediatrics Authors: Byron C. Jaeger Tags: Statistics, Explained Source Type: research

Population-Level Outcomes of Pediatric Acute Promyelocytic Leukemia  in the United States
To determine whether the population level outcomes of pediatric acute promyelocytic leukemia have improved over time. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 29, 2020 Category: Pediatrics Authors: Raji Venkitachalam, Aniko Szabo, Guru Subramanian Guru Murthy Tags: Original Articles Source Type: research

Early Cardiac and Cerebral Hemodynamics with Umbilical Cord Milking Compared with Delayed Cord Clamping in Infants Born Preterm
To evaluate changes in cerebral oxygenation, peripheral arterial oxygenation, respiratory status, and administered fraction of inspired oxygen during the first 10  minutes of life in premature infants receiving umbilical cord milking compared with delayed cord clamping (DCC). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 29, 2020 Category: Pediatrics Authors: Anup C. Katheria, Jeff M. Szychowski, Jochen Essers, Marc R. Mendler, Eugene M. Dempsey, Georg M. Schm ölzer, Kathy Arnell, Wade D. Rich, Kasim Hassen, Phillip Allman, Michael Varner, Gary R. Cutter, Neil Finer Tags: Original Articles Source Type: research

Realizing the Improvement Potential of the Value in Inpatient Pediatrics Network
The gap between evidence-based practice and current clinical care is seen across the spectrum of hospitalized pediatric patients.1,2 The field of quality improvement (QI) was born out of this gap. QI promotes the use of improvement methodologies to both decrease variation and improve the delivery of high-quality care as measured by nationally endorsed benchmarks. Part and parcel to improvement methodologies is the dissemination of the local plan-do-study-act cycle and the importance of starting small in any implementation. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 29, 2020 Category: Pediatrics Authors: Sangeeta K. Schroeder Tags: Editorial Source Type: research

Revascularization of Portal Venous System after Occlusion of Congenital Intrahepatic Portosystemic Shunt
An 11-month-old boy was admitted to our hospital due to unremitting hyperammonemia. He was diagnosed as having an intrahepatic portosystemic shunt (IPSS) at 24  weeks of gestation. He had no significant symptoms, and physical examination revealed good growth and development. Laboratory results showed an elevated serum ammonia level of 61.6 μmol/L (normal, 0-33 μmol/L), along with normal serum bilirubin and aminotransferase levels. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 29, 2020 Category: Pediatrics Authors: Liuxiang Chen, Bo Wei, Bo Xiang, Hao Wu Tags: Insights and Images Source Type: research

Tense Bullae on the Hands
A 5-year-old girl presented to the dermatology clinic for evaluation of pruritic papules and blisters on the hands and forearms for three months. She was seen by her pediatrician, diagnosed with dyshidrotic eczema, and prescribed topical triamcinolone with no improvement. She reported itching everywhere, but her parents noted she most frequently scratched her hands and forearms. The itching was worse at night. No close contacts experienced pruritus. She had no history of inflammatory dermatoses or other medical problems. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 29, 2020 Category: Pediatrics Authors: Christina N. Kraus, Janellen Smith Tags: Rediscovering the Physical Exam Source Type: research

Association between Placental Inflammatory Pathology and Offspring Neurodevelopment at 8 Months, 4, and 7 Years of Age
To examine whether placental inflammatory pathology is associated with subsequent child neurodevelopment. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 28, 2020 Category: Pediatrics Authors: Chang Chen, Danni Lu, Lili Xue, Peng Ren, Huijuan Zhang, Jun Zhang Tags: Original Articles Source Type: research

Actuarial Survival Based on Gestational Age in Days at Birth for Infants Born at < 26 Weeks of Gestation
To provide comprehensive, contemporary information on the actuarial survival of infants born at 22-25 weeks of gestation in Canada. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 28, 2020 Category: Pediatrics Authors: Prakesh S. Shah, Sanaya Rau, Eugene W. Yoon, Ruben Alvaro, Orlando da Silva, Hala Makary, Martine Claveau, Shoo K. Lee, Canadian Neonatal Network (CNN) Investigators Tags: Original Articles Source Type: research

Hand Function at 18 –22 Months Is Associated with School-Age Manual Dexterity and Motor Performance in Children Born Extremely Preterm
To determine associations between 18-22 month (early) hand function and scores on the Movement Assessment Battery for Children, 2nd edition (MABC) at 6-7 years of age (school-age) in extremely preterm children. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 28, 2020 Category: Pediatrics Authors: Andrea F. Duncan, Carla M. Bann, Nathalie L. Maitre, Myriam Peralta-Carcelen, Susan R. Hintz, Eunice Kennedy Shriver National Institute of Child Health and Development Neonatal Research Network Tags: Original Articles Source Type: research

Subacute Liver Failure Following Gene Replacement Therapy for Spinal Muscular Atrophy Type I
We report two cases of transient, drug-induced liver failure following this therapy. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 27, 2020 Category: Pediatrics Authors: Amy G. Feldman, Julie A. Parsons, Cullen M. Dutmer, Aravindhan Veerapandiyan, Einar Hafberg, Nolan Maloney, Cara L. Mack Tags: Brief Reports Source Type: research

Linear Growth between Early and Late Childhood and Cognitive Outcomes at 6 to 9 Years of Age
To assess the extent to which linear growth beyond the early years of life determines later cognitive development. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 26, 2020 Category: Pediatrics Authors: Ravi Prakash Upadhyay, Mari Hysing, Sunita Taneja, Ingrid Kvestad, Nita Bhandari, Tor A. Strand Tags: Original Articles Source Type: research

Cost-effectiveness Analysis of Screening Extremely Low Birthweight Children for Hepatoblastoma Using Serum Alpha-fetoprotein
To evaluate the cost-effectiveness of screening children born at extremely low birth weight (ELBW) for hepatoblastoma using serial serum alpha-fetoprotein (AFP) measurements. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 26, 2020 Category: Pediatrics Authors: Rebecca MacDonell-Yilmaz, Kelly Anderson, Bradley DeNardo, Philippa Sprinz, William V. Padula Tags: Original Articles Source Type: research

Higher or Usual Volume Feedings in Very Preterm Infants: A Randomized Clinical Trial
To determine if higher volume feedings improve postnatal growth among very preterm infants. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 25, 2020 Category: Pediatrics Authors: Colm P. Travers, Timothy Wang, Ariel A. Salas, Erin Schofield, Madeline Dills, Deborah Laney, Aaron Yee, Anisha Bhatia, Lindy Winter, Namasivayam Ambalavanan, Waldemar A. Carlo Tags: Original Articles Source Type: research

Reply to the Letter to the Editor
We thank Grigoletto et al for their thoughtful letter regarding our report.1 We agree with the authors ’ conclusion that clinicians should consider history of asthma and asthma control status when managing children with anaphylaxis. In support of their conclusions, the authors cite a study evaluating anaphylactic reactions from peanuts and tree nuts in an outpatient allergy center.2 In contrast to our report, this study includes limited allergens, and may represent a more severe cohort of patients with a higher predilection for asthma and/or severe anaphylaxis based on their referral to an allergy center. (Source: Th...
Source: The Journal of Pediatrics - May 25, 2020 Category: Pediatrics Authors: Timothy E. Dribin, Kenneth A. Michelson, Yin Zhang, David Schnadower, Mark I. Neuman Tags: Letters to the Editor Source Type: research

Heart Rate and Heart Rate Difference Predicted the Efficacy of Metoprolol on Postural Tachycardia Syndrome in Children and Adolescents
To evaluate the ability of heart rate (HR) and HR difference during head-up tilt test (HUTT). To predict clinical improvement related to metoprolol treatment in children and adolescents with postural tachycardia syndrome (POTS). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 24, 2020 Category: Pediatrics Authors: Shuo Wang, Runmei Zou, Hong Cai, Yuwen Wang, Yiyi Ding, Chuanmei Tan, Maosheng Yang, Fang Li, Cheng Wang Tags: Original Articles Source Type: research

Poor asthma control remains a risk factor for severe anaphylaxis
We have read with interest the report by Dribin et al investigating the association between history of asthma and anaphylaxis severity in children 1. The authors concluded that children hospitalized for anaphylaxis with a past medical history of asthma were not more likely to have severe anaphylactic reactions compared with children without asthma. However, we noticed that asthma control status at the time of anaphylaxis was not determined in the study. As mentioned by the authors, a position paper from the European Academy of Allergy and Clinical Immunology identifies asthma as a risk factor for fatal anaphylaxis, but it ...
Source: The Journal of Pediatrics - May 23, 2020 Category: Pediatrics Authors: Veronica Grigoletto, Laura Badina, Egidio Barbi Tags: Letters to the Editor Source Type: research

Epidemiology, Treatments, and Cardiac Complications in Patients with Kawasaki Disease: The Nationwide Survey in Japan, 2017 –2018
To report the epidemiologic characteristics, treatments, and cardiac complications of KD, using data from the nationwide survey in Japan. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 22, 2020 Category: Pediatrics Authors: Ryusuke Ae, Nobuko Makino, Koki Kosami, Masanari Kuwabara, Yuri Matsubara, Yosikazu Nakamura Tags: Original Articles Source Type: research

Mechanical Ventilation Duration, Brainstem Development, and Neurodevelopment in Children Born Preterm: A Prospective Cohort Study
To determine, In children born preterm, the association of mechanical ventilation duration with brainstem development, white matter maturation, and neurodevelopmental outcomes at preschool age. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 22, 2020 Category: Pediatrics Authors: Mireille Guillot, Ting Guo, Steven Ufkes, Juliane Schneider, Anne Synnes, Vann Chau, Ruth E. Grunau, Steven P. Miller Tags: Original Articles Source Type: research

Trends in Perinatal Practices and Neonatal Outcomes of VLBW Infants during a 16-year Period at NEOCOSUR Centers
To describe trends in mortality, major morbidity and perinatal care practices of VLBW infants born at Neocosur Neonatal Network centers from Jan 1 2001 through Dec 31 2016. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 22, 2020 Category: Pediatrics Authors: Ivonne D'Apremont, Guillermo Marshall, Claudia Musalem, Gonzalo Mariani, Gabriel Musante, Aldo Bancalari, Jorge Fabres, Patricia Mena, Jaime Zegarra, Jorge Tavosnanska, Jose Lacarrubba, Claudio Solana, Catalina Vaz Ferreira, Tamara Herrera, Luis Villarroe Tags: Original Articles Source Type: research

Implementation of a Physician Incentive Program for 18-Month Developmental Screening in Ontario, Canada
To evaluate factors associated with uptake of a financial incentive for developmental screening at an enhanced 18-month well-child visit (EWCV) in Ontario, Canada. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 22, 2020 Category: Pediatrics Authors: Astrid Guttmann, Natasha Ruth Saunders, Matthew Kumar, Sima Gandhi, Christina Diong, Karen MacCon, John Cairney Tags: Original Articles Source Type: research

Prediction Model for the Differential Diagnosis of Kawasaki Disease and Acute Cervical Lymphadenitis in Patients Initially Presenting with Fever and Cervical Lymphadenitis
To distinguish early-stage LFKD from ACL, we developed an algorithm using sequential laboratory marker levels and radiologic findings. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 22, 2020 Category: Pediatrics Authors: Jae Min Kim, Jihye Kim Tags: Original Articles Source Type: research

Functional nausea, gut, brain, or both?
The gut-brain pathways for nausea, distinct from those for vomiting, .1 involve the convergence of the central and autonomic nervous system, endocrine, and gastrointestinal systems.2 Although vomiting is mediated through the brainstem and considered a motor response, nausea has sensory, cognitive, psychological, and homeostatic influences that trigger a response from the limbic system.3 The functional brain network for nausea is wide and the morphology of the subcortex (amygdala, caudate, and putamen) has been associated with the severity of nausea. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 22, 2020 Category: Pediatrics Authors: Neha R. Santucci Tags: Editorials Source Type: research

50 Years Ago in The Journal of Pediatrics
Rhea JW, Akhnoukh F, Parthew CT, Elhassani SB. Convulsion scoring in treatment of neonatal tetanus. J Pediatr 1970;76:949-53. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 21, 2020 Category: Pediatrics Authors: Prerna Batra, Piyush Gupta Tags: Original Article Source Type: research

50 Years Ago in The Journal of Pediatrics
Holsclaw DS, Grand RJ, Shwachman H. Massive hemoptysis in cystic fibrosis. J Pediatr 1970;76:829-38. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 21, 2020 Category: Pediatrics Authors: Abigail Russi Tags: Original Article Source Type: research

50 Years Ago in The Journal of Pediatrics
Ehrenkranz NJ. Bacterial colonization of newborn infants and subsequent acquisition of hospital bacteria. J Pediatr 1970;76:839-47. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 21, 2020 Category: Pediatrics Authors: Margaret L. Aldrich, M. Susan LaTuga Tags: Original Article Source Type: research

50 Years Ago in The Journal of Pediatrics
Kohn G, Taysi K, Atkins TE, Mellman WJ. Mosaic mongolism. I. Clinical correlations. J Pediatr 1970;76:874-9. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 21, 2020 Category: Pediatrics Authors: Jannicke H. Andresen, Ola Didrik Saugstad Tags: Original Article Source Type: research

50 Years Ago in The Journal of Pediatrics
Glueck HI, Will RM, Mcadams AJ, Gleser G. Measurement of prothrombin. A neglected liver function test in infancy and childhood. J Pediatr 1970;76:914-22. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 21, 2020 Category: Pediatrics Authors: Daniel F. Castillo Tags: Original Article Source Type: research