Changes in Strength of Recommendation and Perceived Barriers to HPV Vaccination: Longitudinal Analysis of Primary Care Physicians, 2008-2018
To evaluate among pediatricians and family physicians how human papillomavirus (HPV) vaccination recommendation practices for 11-12 year-old youth; report parental refusal/ deferral of HPV vaccination; and report barriers to HPV vaccination changed over time. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - March 6, 2021 Category: Pediatrics Authors: Jessica R. Cataldi, Sean T. O ’Leary, Lauri E. Markowitz, Mandy A. Allison, Lori A. Crane, Laura P. Hurley, Michaela Brtnikova, Brenda L. Beaty, Carol Gorman, Elissa Meites, Megan C. Lindley, Allison Kempe Tags: Original Articles Source Type: research

Leukemia Risk in a Cohort of 3.9 Million Children With and Without Down Syndrome
To assess leukemia risks among children with Down syndrome in a large, contemporary cohort. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - March 5, 2021 Category: Pediatrics Authors: Emily C. Marlow, Jonathan Ducore, Marilyn L. Kwan, Stephanie Y. Cheng, Erin J.A. Bowles, Robert T. Greenlee, Jason D. Pole, Alanna Kulchak Rahm, Natasha K. Stout, Sheila Weinmann, Rebecca Smith-Bindman, Diana L. Miglioretti Tags: Original Articles Source Type: research

Talking to Parents about Spanking: The Potential for Pediatricians to Reduce the Impact of Adverse Childhood Experiences
Parents ’ use of spanking to punish child misbehavior is replete with controversy despite ample evidence that spanking can lead to harmful outcomes,1 such as increasing child aggressive and externalizing behavior,2-4 internalizing mental health problems,5,6 and compromised brain development.1,7 Empirical conclusions about the effects of spanking no longer derive from weak cross-sectional, correlational research designs. Studies now employ rigorous research designs that approximate true experiments,2,4 account for children’s initial levels of behavior problems to demonstrate increases in problems a fter spanking...
Source: The Journal of Pediatrics - March 5, 2021 Category: Pediatrics Authors: Christina M. Rodriguez Tags: Editorials Source Type: research

The Use of Economic Evaluation in Pediatric Research
The author declares no conflicts of interest. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - March 4, 2021 Category: Pediatrics Authors: Edward CF. Wilson Source Type: research

Persistent Racial/Ethnic Disparities in Supine Sleep Positioning among U.S.-born Preterm Infants, 2000-2015
To assess trends in racial disparity in supine sleep positioning across racial/ethnic groups of early preterm (EPT; (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - March 4, 2021 Category: Pediatrics Authors: Sunah S. Hwang, Suhong Tong, Ruben A. Smith, Wanda D. Barfield, Laura Pyle, Catherine Battaglia, Beth McManus, Susan Niermeyer, Angela Sauaia Tags: Original Articles Source Type: research

Compliance with Early Long-Term Prophylaxis Guidelines for Severe Hemophilia A
To evaluate the applicability and compliance with guidelines for early initiation of long-term prophylaxis in infants with severe hemophilia A and to identify factors associated with guideline compliance. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - March 4, 2021 Category: Pediatrics Authors: Paul Saultier, Yves Guillaume, Virginie Demiguel, Claire Berger, Annie Borel-Derlon, S égolène Claeyssens, Annie Harroche, Caroline Oudot, Anne Rafowicz, Marc Trossaert, Bénédicte Wibaut, Christine Vinciguerra, Mohamed Boucekine, Karine Baumstarck, Sa Tags: Original Articles Source Type: research

A Longitudinal Comparison of Alternatives to CDC BMI Z-Scores for Children With Very High BMIs
The current CDC BMI z-scores are inaccurate for BMIs ≥ 97th percentile. We, therefore, considered 5 alternatives that can be used across the entire BMI distribution: modified BMIz, %CDC95th percentile, extended BMIz, %median, and %median adjusted for the dispersion of BMIs. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - March 4, 2021 Category: Pediatrics Authors: David S. Freedman, Amy J. Goodwin Davies, Lyudmyla Kompaniyets, Samantha J. Lange, Alyson B. Goodman, Thao-Ly Tam Phan, F. Sessions Cole, Amanda Dempsey, Nathan Pajor, Ihuoma Eneli, Dimitri A. Christakis, Christopher B. Forrest Tags: Original Articles Source Type: research

Point of Care Testing Improves Lead Screening Rates at 1 and 2 Year Well Visits
To increase blood lead level screening rates in children at 12 and 24 month well visits through provider education and the implementation of a point of care (POC) lead screening program in four primary care practice offices located in and neighbored by counties with ≥5% prevalence of blood lead levels ≥5 μg/dL. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - March 3, 2021 Category: Pediatrics Authors: Benjamin Carnahan, Eric W. Schaefer, Benjamin N. Fogel Tags: Original Articles Source Type: research

A Masquerader of neonatal persistent pulmonary hypertension
A neonate was born at 37+2 weeks weighing 2444 grams without any birth asphyxia or difficult transition. She was roomed in with mother and started on breastfeeding. At 57 hours of life, she was noted to be lethargic and feeding poorly. On examination, she had tachypnea, tachycardia, pallor and hepatomegaly with a grade 3 ejection systolic murmur suggestive of congestive cardiac failure. She was shifted to neonatal intensive unit immediately, her saturation was 93-97% without significant pre- and post-ductal differences, well palpable femoral pulses and age-appropriate blood pressure records in all 4 limbs. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - March 2, 2021 Category: Pediatrics Authors: Kritika Setlur, Mayank Priyadarshi, Shankhneel Singh, Ankit Verma Tags: Insights and Images Source Type: research

African American Pediatric Liver Transplant Recipients Have an Increased Risk of Death After Transferring to Adult Healthcare
To analyze long-term outcomes in pediatric liver transplant recipients after they have transferred to an adult provider and assess for racial disparities in health outcomes. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - March 2, 2021 Category: Pediatrics Authors: Mikaela Katz, Scott Gillespie, James P. Stevens, Lori Hall, Vasantha Kolachala, Ryan Ford, Keri Levin, Nitika Gupta Tags: Original Articles Source Type: research

Risk Factors of Early Mortality and Morbidity in Esophageal Atresia With Distal Tracheo-Esophageal Fistula: A Population-Based Cohort Study
To identify the risk factors for early mortality and morbidity in a population with distal esophageal atresia (EA)-tracheoesophageal fistula. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - March 2, 2021 Category: Pediatrics Authors: R. Sfeir, V. Rousseau, A. Bonnard, T. Gelas, M. Aumar, N. Panait, C. Piolat, S. Irtan, V. Fouquet, A. Le Mandat, S. De Napoli, E. Habonimana, T. Lamireau, J.L. Lemelle, F. Elbaz, I. Talon, M.L. Polimerol, H. Allal, Ph Buisson, T. Petit, D. Louis, H. Lardy Tags: Original Articles Source Type: research

Associations Among Referral Concerns, Screening Results, and Diagnostic Outcomes of Young Children Assessed in a Statewide Early Autism Evaluation Network
To examine associations between referral concerns, screening results, and diagnostic outcomes for young children evaluated across a statewide primary care network for early screening and diagnosis of ASD. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - March 1, 2021 Category: Pediatrics Authors: Rebecca McNally Keehn, Qing Tang, Nancy Swigonski, Mary Ciccarelli Tags: Original Articles Source Type: research

Universal Cholesterol Screening Among Pediatric Primary Care Providers Within California and Minnesota: A Qualitative Assessment of Barriers and Facilitators
To assess current pediatric cholesterol screening practices, and attitudes, among pediatric primary care providers (PCPs) via qualitative semi-structured interviews designed to identifybarriers and facilitators to universal cholesterol screening practices recommended by the National Heart Blood and Lung Institute and the American Academy of Pediatrics. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - March 1, 2021 Category: Pediatrics Authors: Jenna Soukup, Heather A. Zierhut, Hannah Ison Tags: Original Articles Source Type: research

Neonatal morbidities in infants born late preterm at 35-36 weeks of gestation - a Swedish nationwide population-based study
To assess risk for neonatal morbidities among infants born late preterm at 35-36 gestational weeks, early-term (37-38 weeks), and late-term (41 weeks) infants, compared with full-term (39-40 weeks) infants. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - March 1, 2021 Category: Pediatrics Authors: Ayoub Mitha, Ruoqing Chen, Maria Altman, Stefan Johansson, Olof Stephansson, Jenny Bolk Tags: Original Articles Source Type: research

Growth Failure Prevalence in Neonates with Gastroschisis: A Statewide Cohort Study
To perform a multicenter study to assess growth failure in hospitalized infants with gastroschisis. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 26, 2021 Category: Pediatrics Authors: Katie M. Strobel, Tahmineh Romero, Katelin Kramer, Erika Fernandez, Catherine Rottkamp, Cherry Uy, Roberta Keller, Laurel Moyer, Francis Poulain, Jae H. Kim, Daniel Deugarte, Kara L. Calkins, University of California Fetal Consortium Tags: Original Articles Source Type: research

Child Health Care and Neighborhoods: The Evidence Grows
For more than half a century, sociologists, urban planners, and economists have studied the important role of neighborhood in the well-being of persons living in urban environments. Neighborhood are known to effect crime, economic mobility, young adult well-being, and policy investment opportunities, among others.1-5 (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 26, 2021 Category: Pediatrics Authors: Dr. Kelly Kelleher Tags: Editorials Source Type: research

Fetal Brain MRI Findings Predict Neurodevelopment in Children with Tuberous Sclerosis Complex
To correlate fetal brain MRI findings with epilepsy characteristics and neurodevelopment at two years of age in children with Tuberous Sclerosis Complex (TSC) in order to improve prenatal counseling (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 25, 2021 Category: Pediatrics Authors: Hanna M. Hulshof, Emma M.H. Slot, Maarten Lequin, Delphine Breuillard, Nathalie Boddaert, Sergiusz Jozwiak, Katarzyna Kotulska, Kate Riney, Martha Feucht, Sharon Samueli, Theresa Scholl, Pavel Krsek, Barbora Benova, Kees P.J. Braun, Floor E. Jansen, Rima Tags: Original Articles Source Type: research

Intracranial Hypertension in Multisystem Inflammatory Syndrome in Children (MIS-C)
We present 4 patients with MIS-C who had intracranial hypertension and discuss the unique management considerations when this occurs concurrently with significant myocardial dysfunction. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 25, 2021 Category: Pediatrics Authors: Andrew E. Becker, Kathleen Chiotos, Jennifer L. McGuire, Benjamin B. Bruins, Alicia M. Alcamo Tags: Brief Reports Source Type: research

Corrigendum
After publication, an author of the Current Best Evidence article summary “Single-dose nirsevimab prevents RSV infection” (J Pediatr 2021;228:310-3) requested a change to the spelling of the second author's name. The corrected name appears below and the online version of the article has since been updated. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 24, 2021 Category: Pediatrics Tags: Correction Source Type: research

50 Years Ago in The Journal of Pediatrics
Balsam MJ, Baker L, Kaye R. Hyperosmolar nonketotic coma associated with diazoxide therapy for hypoglycemia. J Pediatr 1971;78:523-5. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 22, 2021 Category: Pediatrics Authors: Lauren E. Boudreau, James F. Padbury Tags: Original Article Source Type: research

50 Years Ago in The Journal of Pediatrics
Nelson JD, Haltalin KC. Accuracy of diagnosis of bacterial diarrheal disease by clinical features. J Pediatr 1971;78:519-22. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 22, 2021 Category: Pediatrics Authors: Chabungbam Smilie, Piyush Gupta Tags: Original Article Source Type: research

50 Years Ago in The Journal of Pediatrics
Haicken BN, Miller DR. Simultaneous occurrence of congenital aniridia, hamartoma and Wilms' tumor. J Pediatr 1971;78:497-502 (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 22, 2021 Category: Pediatrics Authors: Philip F. Giampietro Tags: Original Article Source Type: research

50 Years Ago in The Journal of Pediatrics
Mauer SM, Fraley EE, Fish AJ, Najarian JS. Bilateral renal vein thrombosis in infancy: report of a survivor following surgical intervention. J Pediatr 1971;78:266-72. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 22, 2021 Category: Pediatrics Authors: Alexandra Mazo, Beatrice Goilav Tags: Original Article Source Type: research

50 Years Ago in The Journal of Pediatrics
Penny R, Thompson RG, Polmar SH, Schultz RB. Pancreatitis, malabsorption, and IgA deficiency in a child with diabetes. J Pediatr 1971;78:512-6. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 22, 2021 Category: Pediatrics Authors: Jennifer Ni, Chaitan Khosla, David M. Maahs Tags: Original Article Source Type: research

50 Years Ago in The Journal of Pediatrics
Freedman MH, Finklestein JZ, Hammond GD, Karon M. The effect of chemotherapy on acute myelogenous leukemia. J Pediatr 1971;78:526-32 (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 22, 2021 Category: Pediatrics Authors: Michael J. Ferguson, Sandeep Batra Tags: Original Article Source Type: research

50 Years Ago in The Journal of Pediatrics
Cordero L, Hon EH. Neonatal bradycardia following nasopharyngeal stimulation. J Pediatr 1971;78:441-7. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 22, 2021 Category: Pediatrics Authors: Anne Lee Solev åg, Ola Didrik Saugstad Tags: Original Article Source Type: research

50 Years Ago in The Journal of Pediatrics
Glezen WP, Loda FA, Clyde WA Jr, Senior RJ, Sheaffer CI, Conley WG, et  al. Epidemiologic patterns of acute lower respiratory disease of children in a pediatric group practice. J Pediatr 1971;78:397-406. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 22, 2021 Category: Pediatrics Authors: Diego I. Rodr íguez-Mendoza, Jesús A. Vázquez-Mena Tags: Original Article Source Type: research

50 Years Ago in The Journal of Pediatrics
Reisner SH, Perlman M, Ben-Tovim N, Dubrawski C. Transient lateral rectus muscle paresis in the newborn infant. J Pediatr 1971;78:461-5. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 22, 2021 Category: Pediatrics Authors: Jannicke H. Andresen, Ola Didrik Saugstad Tags: Original Article Source Type: research

50 Years Ago in The Journal of Pediatrics
Gross S, Melhorn D. Exchange transfusion with citrated whole blood for disseminated intravascular coagulation. J Pediatr 1971;78:415-9. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 22, 2021 Category: Pediatrics Authors: William B. Mitchell Tags: Original Article Source Type: research

50 Years Ago in The Journal of Pediatrics
Kaplan BS, Katz J, Krawitz S, Lurie A, Path F. An Analysis of the Results of Therapy in 67 Cases of the Hemolytic-Uremic Syndrome. J Pediatr 1971;78:420-5. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 22, 2021 Category: Pediatrics Authors: Cynthia A. Salinas Silva, Sara E. Ortega Alonzo Tags: Original Article Source Type: research

Lower-dose zinc non-inferior to standard dose in diarrhea treatment and with less emesis
Dhingra U, Kisenge R, Sudfeld CR, Dhingra P, Somji S, Dutta A, et al. Lower-Dose Zinc for Childhood Diarrhea - A Randomized, Multicenter Trial. N Engl J Med 2020;383:1231-41. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 22, 2021 Category: Pediatrics Authors: Maxwell A. Barffour, Kwame Frimpong Tags: Current Best Evidence Source Type: research

Early cow's milk formula prevents milk protein allergy
Sakihara T, Otsuji K, Arakaki Y, Hamada K, Sugiura S, Ito K. Randomized trial of early infant formula introduction to prevent cow's milk allergy. J Allergy Clin Immunol 2020:S0091-6749(20)31225-2. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 22, 2021 Category: Pediatrics Authors: Mitsuyoshi Urashima, Hiroshi Tachimoto Tags: Current Best Evidence Source Type: research

Early term-infant discharge associated with higher re-admission rates
Jones E, Taylor B, MacArthur C, Bradshaw S, Hope L, Cummins C. Early Postnatal Discharge for Infants: A Meta-analysis. Pediatrics 2020;146:e20193365. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 22, 2021 Category: Pediatrics Authors: Henry Chong Lee, Jeffrey B. Gould Tags: Current Best Evidence Source Type: research

Pediatric hypertension over a 6-year period
Kaelber DC, Localio AR, Ross M, Leon JB, Pace WD, Wasserman RC, Grundmeier RW, Steffes J, Fiks AG. Persistent Hypertension in Children and Adolescents: A 6-Year Cohort Study. Pediatrics 2020;146:e20193778. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 22, 2021 Category: Pediatrics Authors: Simonetta Genovesi, Gianfranco Parati Tags: Current Best Evidence Source Type: research

Arrhythmias associated with SSRI use in children and young adults
Czaja AS, Anderson HD, Ghosh D, Davidson J, Campbell JD, Valuck RJ. Increased Odds of Ventricular Arrhythmias Associated with Selective Serotonin Reuptake Inhibitor Use among the Pediatric and Young Adult Population: A Case-Control Study. J Pediatr 2020;226:173-8. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 22, 2021 Category: Pediatrics Authors: Chi-Chuan Wang, Ting-An Yen Tags: Current Best Evidence Source Type: research

Overweight is associated with early puberty in boys and girls
It has been clear that overweight and obesity in childhood is associated with onset of puberty at a younger age in girls. For boys, this has been less clear and study results have been variable. One issue is that defining onset of puberty may be more difficult in boys compared with girls. In this volume of The Journal, Chen et al used data from the Boston Birth Cohort Study to evaluate this question. They used age at peak height velocity as a marker of puberty. They found that overweight or obesity from age 2-7 years is associated with earlier onset of puberty in boys as well as in girls. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 22, 2021 Category: Pediatrics Authors: Stephen R. Daniels Tags: The Editors' Perspectives Source Type: research

Cyber school is a marker of youth with high-risk diabetes
The COVID-19 pandemic has impacted child health negatively in the past year, including significant effects on child education and development. School systems have transitioned to remote learning strategies with varying success for individual students. Concerns exist that online school may exacerbate disparities for youth in families with less technical capabilities and parental support. In a timely report, March et al from the University of Pittsburgh explore the health characteristics of youth with diabetes in cyber school compared with peers with diabetes in traditional brick-and-mortar schools in 2017-2018, pre-COVID-19...
Source: The Journal of Pediatrics - February 22, 2021 Category: Pediatrics Authors: David M. Maahs Tags: The Editors' Perspectives Source Type: research

Primary ciliary dyskinesia: A neonatal disease?
In this volume of The Journal, Horani and Ferkol update our current understanding of primary ciliary dyskinesia and other ciliopathies. Although neonatologists may be tempted to bypass this article, it is relevant to newborn patients because ciliary function and diseases are of increasing importance in fetal development (eg, determination of body laterality) and neonatal illnesses. The authors report that the majority of infants with primary ciliary dyskinesia present with early and prolonged neonatal respiratory distress or with laterality disorders. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 22, 2021 Category: Pediatrics Authors: Raye-Ann deRegnier Tags: The Editors' Perspectives Source Type: research

Interpretation of ambulatory blood pressure monitoring results
Hypertension is an important risk factor for development of cardiovascular disease. However, it can be difficult to diagnose hypertension because blood pressure changes frequently over time and may be elevated in response to being in a clinical care setting. Twenty-four-hour ambulatory blood pressure monitoring (ABPM) is one method for evaluating blood pressure over the course of the day and night. One difficulty with ABPM is knowing the best approach to interpretation of the blood pressure data. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 22, 2021 Category: Pediatrics Authors: Stephen R. Daniels Tags: The Editors' Perspectives Source Type: research

Table of Contents
(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 22, 2021 Category: Pediatrics Source Type: research

Masthead
(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 22, 2021 Category: Pediatrics Source Type: research

Information for Readers
(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 22, 2021 Category: Pediatrics Source Type: research

Corrigendum
In the article “Dietary Treatment with Extensively Hydrolyzed Casein Formula Containing the Probiotic Lactobacillus rhamnosus GG Prevents the Occurrence of Functional Gastrointestinal Disorders in Children with Cow's Milk Allergy” (J Pediatr 2019;213:137-42.E2), the authors reported an error in the Results sec tion. In the last two paragraphs of the Results section, the LGG cohort should be replaced with the EHCF cohort in 3 places. The corrected paragraphs appear below. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 22, 2021 Category: Pediatrics Tags: Correction Source Type: research

Sirolimus can Increase the Disappearance Rate of Cardiac Rhabdomyomas Associated with Tuberous Sclerosis: A Prospective Cohort and Self-controlled Case Series Study
To investigate the efficacy and safety of sirolimus in the treatment of cardiac rhabdomyomas ) associated with tuberous sclerosis complex (TSC) and the specific benefits in different subgroups. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 22, 2021 Category: Pediatrics Authors: Xiao-Qiao Chen, Yang-Yang Wang, Meng-Na Zhang, Qian Lu, Ling-Yu Pang, Li-Ying Liu, Yu-Fen Li, Li-Ping Zou Tags: Original Articles Source Type: research

Blood Pressure Response to Treadmill Cardiopulmonary Exercise Test in Children with Normal Cardiac Anatomy and Function
To describe blood pressure (BP) responses during cardiopulmonary exercise testing (CPET) and propose criteria for abnormal BP responses in children with normal hearts. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 21, 2021 Category: Pediatrics Authors: Takeshi Sasaki, Yuki Kawasaki, Daiji Takajo, Chenni Sriram, Robert D. Ross, Daisuke Kobayashi Tags: Original Articles Source Type: research

Reply
We welcome the opportunity to explain our findings further. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 21, 2021 Category: Pediatrics Authors: S. Villaverde, P. Merino-Amador, P. Mendoza, D. Molina-Arana, M.P. Romero, C. Moraleda, A. Tagarro Tags: Letters to the Editor Source Type: research

Diagnostic performance of antigen testing for SARS-CoV-2
We read with interest the brief report by Villaverde et al(1) in which the authors posit a low diagnostic performance of antigen testing for SARS-CoV-2 in children. We agree that reverse transcriptase polymerase chain reaction testing (RT-PCR) is the diagnostic gold standard and that it would be desirable to perform timely RT-PCR in every suspect case, which unfortunately is not realistic. After a detailed consideration of their article, we would like to offer the following remarks. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 21, 2021 Category: Pediatrics Authors: Álvaro Marchán-López, Blanca Ayuso García Tags: Letters to the Editor Source Type: research

Acetaminophen and the developing lung: could there be lifelong consequences?
The use of acetaminophen (paracetamol, APAP) in the neonatal intensive care unit (NICU) has become ubiquitous. Between 2005-2010, APAP was the 15th most common pharmacologic exposure among infants admitted to the Pediatrix-affiliated NICUs in the United States.1 Over nearly the same period of time, a significant increase in the use of APAP was reported in German NICUs, occurring in 8.1% of all infants with very low birth weights by 2010.2 Since 2010, multiple reports indicate increasing APAP use in NICUs around the world. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 19, 2021 Category: Pediatrics Authors: Clyde J. Wright Tags: Commentary Source Type: research

QTc in Diabetic Ketoacidosis
I read with interest the retrospective observational study by Perez et al where the authors had demonstrated a significant association between QTc intervals and diabetic ketoacidosis (DKA) severity.(1) Although their point on appropriate cardiac monitoring in moderate or severe DKA is well taken, several observations are noteworthy. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 18, 2021 Category: Pediatrics Authors: Ng Nicholas Beng Hui Tags: Letters to the Editor Source Type: research

Reply
We thank Dr Ng; the comments focus on the potential inaccuracy of the Bazett QT correction formula at elevated heart rates and the effect of serum electrolytes on the QTc. The references provided by the author mention concerns about the inaccuracy of the Bazett formula at extreme heart rates and the possibility for overcorrection2,3. While we agree that there is a potential for overcorrection of the QTc at extreme heart rates, our patient population had mean heart rates of 107, 117 and 129 bpm in the mild, moderate and severe categories respectively. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 18, 2021 Category: Pediatrics Authors: Michelle M. Perez, Bradley C. Clark Tags: Letters to the Editor Source Type: research