50 Years Ago in The Journal of Pediatrics
Adams FH, Latta H, el-Salawy A, Nozaki M. J Pediatr 1969;75:59-66. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 21, 2019 Category: Pediatrics Authors: Alan H. Jobe Source Type: research

50 Years Ago in The Journal of Pediatrics
Satran L, Sharp H, Schenken JR, Krivit W. J Pediatr 1969;75:39-46. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 21, 2019 Category: Pediatrics Authors: Soofia Khan, William Balistreri Source Type: research

50 Years Ago in The Journal of Pediatrics
Pagano JS. J Pediatr 1969;75:162-3. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 21, 2019 Category: Pediatrics Authors: Vipin M. Vashishtha, Piyush Gupta Source Type: research

50 Years Ago in The Journal of Pediatrics
Breese BB. J Pediatr 1969;75:164-166. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 21, 2019 Category: Pediatrics Authors: Sarah S. Long Source Type: research

50 Years Ago in The Journal of Pediatrics
Weil WB. J Pediatr 1969;75(1):1-12. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 21, 2019 Category: Pediatrics Authors: Nidhi Bedi, Piyush Gupta Source Type: research

50 Years Ago in The Journal of Pediatrics
Weinberg H, Terry C. J Pediatr 1969;75:111-5. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 21, 2019 Category: Pediatrics Authors: Lyzette A. Garc ía Bonilla Source Type: research

Impact of Cystic Fibrosis on Unaffected Siblings: A Systematic Review
To conduct a systematic review of the evidence to determine the impact of cystic fibrosis (CF) on unaffected siblings. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 21, 2019 Category: Pediatrics Authors: Jane Chudleigh, Ryan Browne, Catherine Radbourne Tags: Original Article Source Type: research

The Risk of Gambling Disorders in Children and Adolescents
Gambling disorders should be regarded as a public health issue, with adverse consequences for individuals and families. Over the past 25  years, the phenomenon of gambling among children and adolescents has grown, particularly in economically advantaged countries. Reports on youth gambling performed during this period have revealed increasing incidence and prevalence rates, which emphasize the possibility that negative effects relat ed to gambling disorders will progressively impact children and adolescents' health and well-being. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 21, 2019 Category: Pediatrics Authors: Pietro Ferrara, Mehmet Vural, Fugen Cullu Cokugras, Luigi Nigri, Tudor Lucian Pop, Julije Mestrovic, Ida Giardino, Leyla Namazova-Baranova, Massimo Pettoello-Mantovani Tags: European Paediatric Association Source Type: research

Maternal infection associated with autism and depression in their offspring
Al-Haddad BJS, Jacobsson B, Chabra S, Modzelewska D, Olson EM, Bernier R, et al. Long-term Risk of Neuropsychiatric Disease After Exposure to Infection In Utero. JAMA Psychiatry 2019, in press. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 21, 2019 Category: Pediatrics Authors: Quetzal A. Class Tags: Current Best Evidence Source Type: research

Positional plagiocephaly/brachycephaly is associated with later cognitive and academic outcomes
Collett BR, Wallace ER, Kartin D, Cunningham ML, Speltz ML. Cognitive Outcomes and Positional Plagiocephaly. Pediatrics 2019;143. pii: e20182373. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 21, 2019 Category: Pediatrics Authors: Sarah Knight Tags: Current Best Evidence Source Type: research

iBsafe app enhances safety skills and knowledge among young children
Dixon CA, Ammerman RT, Johnson BL, Lampe C, Hart KW, Lindsell CJ, et al. A randomized controlled field trial of iBsafe-a novel child safety game app. Mhealth 2019;5:3. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 21, 2019 Category: Pediatrics Authors: David C. Schwebel Tags: Current Best Evidence Source Type: research

Cyclosporine and coronary outcomes in Kawasaki disease
Hamada H, Suzuki H, Onouchi Y, Ebata R, Terai M, Fuse S, et al. Efficacy of primary treatment with immunoglobulin plus ciclosporin for prevention of coronary artery abnormalities in patients with Kawasaki disease predicted to be at increased risk of non-response to intravenous immunoglobulin (KAICA): A randomized controlled, open-label blinded endpoints, phase 3 trial. Lancet 2019;393:1128-37. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 21, 2019 Category: Pediatrics Authors: Jane C. Burns Tags: Current Best Evidence Source Type: research

Children older than 12 months and with commercial insurance at risk for delayed treatment of UTI
Hum SW, Shaikh N. Risk Factors for Delayed Antimicrobial Treatment in Febrile Children with Urinary Tract Infections. J Pediatr 2019;205:126-9. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 21, 2019 Category: Pediatrics Authors: Alexandra Soldatou Tags: Current Best Evidence Source Type: research

Thanks to our Valued Reviewers —2018
The Editors gratefully acknowledge all reviewers who completed reviews for The Journal in 2018.Thank you for helping The Journal to maintain a prompt, fair peer-review process. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 21, 2019 Category: Pediatrics Tags: List of Reviewers Source Type: research

Will resilience give hope to youth with chronic musculoskeletal pain?
Gmuca et al assessed the level of resilience in 30 adolescents between ages 13 to 17 years (and their parents) with non-inflammatory chronic musculoskeletal pain syndromes. Resilience is defined as the ability to recover from or adjust easily to misfortune or change. They found that patients and parents had low to moderate levels of resilience, lower than previously reported among healthy populations as well as those with chronic medical conditions. Resilience negatively correlated with the pain level, physical disability, and symptom severity while showing a positive correlation with the energy level and health-related qu...
Source: The Journal of Pediatrics - June 21, 2019 Category: Pediatrics Authors: Philip J. Hashkes Tags: The Editors' Perspectives Source Type: research

Yet another screen
Busy generalists may, at first, roll their eyes to see that the current volume of The Journal includes a report describing another “brief screening tool” which can be used in a “busy clinical environment.” “Don't we have enough of these?” one may ask. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 21, 2019 Category: Pediatrics Authors: Thomas R. Welch Tags: The Editors' Perspectives Source Type: research

Who goes home on oxygen after a NICU stay?
Bronchopulmonary dysplasia (BPD) is the most common morbidity of extreme prematurity, and despite innovations in respiratory management, its incidence continues to rise. As an infant with BPD approaches term-equivalent gestation, one of the key questions is whether supplemental oxygen will be needed at home. Clinicians are required to balance the benefits of earlier discharge with the challenges of introducing medical equipment and monitoring into the household. These problems are made more difficult by the lack of knowledge on the benefits and risks of supplemental oxygen use beyond the birth hospitalization. (Source: The...
Source: The Journal of Pediatrics - June 21, 2019 Category: Pediatrics Authors: Robin H. Steinhorn Tags: The Editors' Perspectives Source Type: research

Mandated Research Peer Review Positively Impacts Research Funding Success Rates for Young Investigators
Successful receipt of funding for biomedical research requires a compelling and significant question that is addressed with an innovative and rigorous scientific approach. These features are necessary but not sufficient. Specifically, the significance of the idea and the innovation and rigor of the approach must be presented in a written application with clarity and precision. The need for clear, effective written communication in research grant applications has become increasingly important as application numbers continue to rise and success rates fall. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 21, 2019 Category: Pediatrics Authors: Valerie P. Opipari, Julie C. Lumeng, Becky Youmans, Faye Silverstein Tags: Notes from the Association of Medical School Pediatric Department Chairs, Inc. Source Type: research

Table of Contents
(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 21, 2019 Category: Pediatrics Source Type: research

Masthead
(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 21, 2019 Category: Pediatrics Source Type: research

Information for Readers
(Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 21, 2019 Category: Pediatrics Source Type: research

Genome Sequencing Identifies the Pathogenic Variant Missed by Prior Testing in an Infant with Marfan Syndrome
We describe an infant with a phenotype typical of early onset Marfan syndrome whose genetic evaluation, including Sanger sequencing and deletion/duplication testing of FBN1 and exome sequencing, was negative. Ultimately, genome sequencing revealed a deletion missed on prior testing, demonstrating the unique utility of genome sequencing for molecular genetic diagnosis. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 21, 2019 Category: Pediatrics Authors: Monica H. Wojcik, Katri Thiele, Carly F. Grant, Katherine Chao, Julia Goodrich, Anne O'Donnell-Luria, Ronald V. Lacro, Wen-Hann Tan, Pankaj B. Agrawal Tags: Brief Reports Source Type: research

Necrotizing Enterocolitis: Using Regulatory Science and Drug Development to Improve Outcomes
Necrotizing enterocolitis (NEC) is the most common intestinal pathology and cause of death between 2 and 8  weeks of life in neonates born extremely preterm. NEC has an unpredictable and often sudden onset with a rapidly progressive clinical course.1 The diagnosis is currently made through a constellation of clinical observations and radiographic findings (eg, abdominal distention, bloody stool, pneumat osis intestinalis). NEC is likely triggered by a variety of insults resulting in a final pathway of intestinal dysfunction, inflammation, injury, and necrosis. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 21, 2019 Category: Pediatrics Authors: Michael S. Caplan, Mark A. Underwood, Neena Modi, Ravi Patel, Phillip V. Gordon, Karl G. Sylvester, Steven McElroy, Paolo Manzoni, Sheila Gephart, Walter J. Chwals, Mark A. Turner, Jonathan M. Davis, Necrotizing Enterocolitis Workgroup of the Internationa Tags: Commentary Source Type: research

Associations of Neonatal Noncardiac Surgery with Brain Structure and Neurodevelopment: A Prospective Case-Control Study
To examine the associations of neonatal noncardiac surgery with newborn brain structure and neurodevelopment at 2  years of age. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 21, 2019 Category: Pediatrics Authors: Margaret M. Moran, Julia K. Gunn-Charlton, Jennifer M. Walsh, Jeanie L.Y. Cheong, Peter J. Anderson, Lex W. Doyle, Susan Greaves, Rod W. Hunt Tags: Original Article Source Type: research

Development of the Serum α-Fetoprotein Reference Range in Patients with Beckwith-Wiedemann Spectrum
To establish reference ranges for serum α-fetoprotein (AFP) at various ages in patients with Beckwith-Wiedemann spectrum (BWSp), to better predict the risk for hepatoblastoma in this population. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 21, 2019 Category: Pediatrics Authors: Kelly A. Duffy, Jennifer L. Cohen, Okan U. Elci, Jennifer M. Kalish Tags: Original Article Source Type: research

Sex and Ethnic Differences in the Relationship between Changes in Anthropometric Measurements and Visceral Fat in Adolescents with Obesity
To examine sex and ethnic differences in how baseline and changes in anthropometric measures relate with change in visceral fat with interventions in adolescents. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 21, 2019 Category: Pediatrics Authors: Jennifer L. Kuk, SoJung Lee Tags: Original Article Source Type: research

Management of Asymptomatic Wolff-Parkinson-White Pattern by Pediatric Electrophysiologists
To determine the present-day approach of pediatric cardiac electrophysiologists to asymptomatic Wolff-Parkinson-White (WPW) pattern and to contrast to both published consensus statements and a similar survey. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 21, 2019 Category: Pediatrics Authors: Henry Chubb, Robert M. Campbell, Kara S. Motonaga, Scott R. Ceresnak, Anne M. Dubin Tags: Original Article Source Type: research

Risk of Meningitis in Infants Aged 29 to 90  Days with Urinary Tract Infection: A Systematic Review and Meta-Analysis
To determine the risk of bacterial meningitis in infants aged 29-90  days with evidence of urinary tract infection (UTI). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 20, 2019 Category: Pediatrics Authors: James Nugent, Molly Childers, Nicholas Singh-Miller, Robin Howard, Rhonda Allard, Matthew Eberly Tags: Original Article Source Type: research

Maintenance Following a Randomized Trial of a Clinic and Home-based Behavioral Intervention of Obesity in Preschoolers
To assess maintenance of improved weight outcomes in preschoolers with obesity 6 and 12  months following a randomized clinical trial comparing a home- and clinic-based behavioral intervention (Learning about Activity and Understanding Nutrition for Child Health [LAUNCH]) to motivational interviewing and standard care. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 20, 2019 Category: Pediatrics Authors: Lori J. Stark, Stephanie Spear Filigno, Jessica C. Kichler, Christopher Bolling, Megan B. Ratcliff, Shannon M. Robson, Stacey L. Simon, Mary Beth McCullough, Lisa M. Clifford, Cathleen Odar Stough, Cynthia Zion, Constance A. Mara Tags: Original Article Source Type: research

Characteristics Associated with Successful Weight Management in Youth with Obesity
To identify the medical, demographic, and behavioral factors associated with a reduction of body mass index percent of the 95th percentile (BMIp95) after 1  year for patients receiving care at a tertiary care obesity management clinic. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 20, 2019 Category: Pediatrics Authors: Michelle C. Gorecki, Joseph M. Feinglass, Helen J. Binns Tags: Original Articles Source Type: research

Confidentiality in the Doctor-Patient Relationship: Perspectives of Youth Ages 14-24  Years
To describe the experiences of youth regarding confidentiality with their healthcare provider and how confidentiality affects their interactions with the healthcare system. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 20, 2019 Category: Pediatrics Authors: Noah A. Zucker, Christine Schmitt, Melissa J. DeJonckheere, Lauren P. Nichols, Melissa A. Plegue, Tammy Chang Tags: Original Article Source Type: research

Prolonged PR Interval and Erythema Marginatum in a Child with Acute Rheumatic Fever
A 9-year-old girl presented to the emergency department with bilateral hip pain. Eight days before onset, she had fever and sore throat that recovered spontaneously. On physical examination, tenderness of both hip joints was observed but no heart murmur. Body temperature was 36.8 °C. Blood tests showed elevated C-reactive protein (4.4 mg/dL) and antistreptolysin O titer (4540 IU/mL). Throat culture revealed Streptococcus pyogenes (M3 serotype [emm3.95 genotype] was isolated). A 12-lead standard electrocardiogram revealed a longer PR interval than that before onset (Figure  1, A and B). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 19, 2019 Category: Pediatrics Authors: Toshihiro Matsui, Kenichi Yamaguchi, Tadayoshi Ikebe, Saori Aiga, Isao Kusakawa Tags: Insights and Images Source Type: research

Impact of Socioeconomic Status on Outcomes of Patients with Kawasaki Disease
To evaluate the association of neighborhood socioeconomic status (SES) with time to intravenous immunoglobulin treatment, length of stay (LOS), and coronary artery aneurysms (CAAs) in patients with Kawasaki disease. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 19, 2019 Category: Pediatrics Authors: Audrey Dionne, Emily M. Bucholz, Kimberlee Gauvreau, Patrick Gould, Mary Beth F. Son, Annette L. Baker, Sarah D. de Ferranti, David R. Fulton, Kevin G. Friedman, Jane W. Newburger Tags: Original Article Source Type: research

Comparing the Risk of Sudden Unexpected Infant Death to Common Causes of Childhood Injury Death
In a secondary analysis of publicly available data, the rate of sudden unexplained infant death in the first year exceeded the peak rates of the leading causes of injury death for youth ( ≤19 years of age). The absolute risk of sudden unexplained infant death exceeded age-specific risks of the major causes of child injury mortality regardless of race or ethnicity. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 19, 2019 Category: Pediatrics Authors: Douglas R. Roehler, Erich K. Batra, Kyran P. Quinlan Tags: Brief Report Source Type: research

Late-Onset Circulatory Collapse and Risk of Cerebral Palsy in Extremely Preterm Infants
To investigate whether the development of postnatal, late-onset refractory hypotension, referred to as late-onset circulatory collapse, was associated with an increased risk of developing cerebral palsy (CP) at 3  years of age in extremely preterm infants. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 19, 2019 Category: Pediatrics Authors: Kazuaki Yasuoka, Hirosuke Inoue, Naoki Egami, Masayuki Ochiai, Koichi Tanaka, Toru Sawano, Hiroaki Kurata, Masako Ichiyama, Junko Fujiyoshi, Yuki Matsushita, Yasunari Sakai, Shouichi Ohga, Neonatal Research Network of Japan Tags: Original Article Source Type: research

Near Adult Height in Girls with Turner Syndrome Treated with Growth Hormone Following Either Induced or Spontaneous Puberty
To understand whether spontaneous vs induced puberty and the type and route of estrogen influence the height of girls with Turner syndrome on growth hormone (GH). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 18, 2019 Category: Pediatrics Authors: Roberto Lanes, Anders Lindberg, Martin Carlsson, Dionisios Chrysis, Ferah Aydin, Cecilia Camacho-H übner, Donna King, Marsha Davenport Tags: Original Article Source Type: research

Damaging Variants in Proangiogenic Genes Impair Growth in Fetuses with Cardiac Defects
To determine the impact of damaging genetic variation in proangiogenic pathways on placental function, complications of pregnancy, fetal growth, and clinical outcomes in pregnancies with fetal congenital heart defect. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 18, 2019 Category: Pediatrics Authors: Mark W. Russell, Julie S. Moldenhauer, Jack Rychik, Nancy B. Burnham, Erin Zullo, Samuel I. Parry, Rebecca A. Simmons, Michal A. Elovitz, Susan C. Nicolson, Rebecca L. Linn, Mark P. Johnson, Sunkyung Yu, Matthew G. Sampson, Hakon Hakonarson, J. William Ga Tags: Original Article Source Type: research

Gastroenteritis, Hepatitis, Encephalopathy, and Human Herpesvirus 6 Detection in an Immunocompetent Child: Benefits and Risks of Syndromic Multiplex Molecular Panel Testing
An immunocompetent toddler came to medication attention with gastroenteritis, complicated by encephalopathy and hepatitis. Multiplexed testing using a polymerase chain reaction meningitis panel was positive for human herpesvirus 6 (HHV-6). Clinical correlation, quantitative HHV-6 polymerase chain reaction, and metagenomic next-generation sequencing supported a likely diagnosis of primary HHV-6B infection. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 14, 2019 Category: Pediatrics Authors: Christina A. Olson, Samuel R. Dominguez, Steve Miller, Charles Y. Chiu, Kevin Messacar Tags: Brief Reports Source Type: research

Use of a Modified Early-Onset Sepsis Risk Calculator for Neonates Exposed to Chorioamnionitis
To validate the recently modified Kaiser Permanente early-onset sepsis (EOS) calculator with a higher baseline incidence in chorioamnionitis exposed neonates. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 14, 2019 Category: Pediatrics Authors: Amy J. Sloane, Cassandra Coleman, David L. Carola, Margaret A. Lafferty, Caroline Edwards, Jay Greenspan, Zubair H. Aghai Tags: Original Article Source Type: research

Seizure Rescue Medication Use among US Pediatric Epilepsy Providers: A Survey of the Pediatric Epilepsy Research Consortium
To assess how pediatric neurologists prescribe home seizure rescue medications to treat acute prolonged seizures and clusters of seizures in children. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 14, 2019 Category: Pediatrics Authors: Adam Wallace, Elaine Wirrell, Eric Payne Tags: Original Articles Source Type: research

Larva Eruption: A Furuncle in a Returned Traveller
A 3-year-old boy presented to the emergency department with a 5-day history of a progressive painful swelling to his scalp. He had recently returned to Australia following a 3-month vacation in East Africa. He was systemically well, with no previous medical history of note. Just before presentation, apparent movement had been noted at the punctum of the lesion, and a single larva had been expressed and removed by the patient's mother. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 14, 2019 Category: Pediatrics Authors: Daniel K. Yeoh, Coen Butters, Andrew J. Daley, Amanda Gwee Tags: Insights and Images Source Type: research

Assessing the Efficacy of Very Early Motor Rehabilitation in Children with Down Syndrome
Among children with Down syndrome, the frequency of motor rehabilitation intervention and the age at the start of this intervention are independently related to the age at onset of independent walking. Early motor rehabilitation, before age 6  months, may be effective in reducing motor delay in children with Down syndrome. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 14, 2019 Category: Pediatrics Authors: Seigo Okada, Takahiro Uejo, Reiji Hirano, Haruka Nishi, Ikuko Matsuno, Takeshi Muramatsu, Mayu Fujiwara, Akiko Miyake, Yusuke Okada, Shinnosuke Fukunaga, Yuichi Ishikawa Tags: Brief Reports Source Type: research

Short Sleep Duration and Later Overweight in Infants
To provide further knowledge about the longitudinal association between sleep duration and overweight in infants. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 14, 2019 Category: Pediatrics Authors: Tuuli Tuohino, Isabel Morales-Mu ñoz, Outi Saarenpää-Heikkilä, Olli Kiviruusu, Tiina Paunio, Petteri Hovi, Kirsi H. Pietiläinen, E. Juulia Paavonen Tags: Original Article Source Type: research

More on the impact of American Academy of Pediatrics palivizumab guidance for infants with respiratory syncytial virus infection
According to the 2014 American Academy of Pediatrics (AAP) recommendations, preterm infants born at ≥29 weeks' gestational age (WGA) no longer qualify for palivizumab prophylaxis, unless they have additional risks.1 To evaluate the effects of this AAP restriction on respiratory syncytial virus (RSV) infections, Zembles et al2 compared data on RSV-associated hospitalizations (RSVaH) related to 2 seasons before (pre-AAP) and 3 seasons after (post-APP) the implementation of the revised recommendations. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 13, 2019 Category: Pediatrics Authors: Michela Silvestri, Oliviero Sacco, Giovanni A. Rossi Tags: Letters to the Editor Source Type: research

Reply
We thank Rossi et  al for commenting on our study supporting adherence to the American Academy of Pediatrics (AAP) recommendations for palivizumab prophylaxis among children at ≥29 and  (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 13, 2019 Category: Pediatrics Authors: Tracy N. Zembles, Glenn Bushee, Rodney E. Willoughby Tags: Letters to the Editor Source Type: research

Involuntary Movements with Abnormal Brain Imaging Led to the Diagnosis
A 17-year-old girl presented to the neurology clinic with a 1-year history of imbalance and falls. She resided at a long-term psychiatric care facility where the staff had also noticed worsening slurred speech, a softening of her voice, and a blank facial expression. She was not raised by her parents and did not know details of her birth, developmental, or family histories. On neurologic examination, she had mild hypomimia, slowing of vertical and horizontal saccadic eye movements, mild bilateral rigidity and bradykinesia in both extremities, motor impersistence with tongue protrusion, and rare chorea seen in her hands and...
Source: The Journal of Pediatrics - June 13, 2019 Category: Pediatrics Authors: William M. Webb, Philip R. Chapman, Victor W. Sung, Marissa N. Dean Tags: Insights and Images Source Type: research

Free Vitamin D: Relationship to Insulin Sensitivity and Vascular Health in Youth
To evaluate the relationship of free 25 hydroxy vitamin D [free 25(OH)D] or bioavailable vitamin D (BioD) concentrations to insulin sensitivity and cardiovascular disease risk markers in normal weight and overweight youth. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 11, 2019 Category: Pediatrics Authors: Fida Bacha, Sara Klinepeter Bartz, Anca Tomsa, Susan Sharma Tags: Original Article Source Type: research

Cross-Sectional Study of Arterial Stiffness in Adolescents with Down Syndrome
To test whether youth with Down syndrome  have aortic stiffness indices, as measured by pulse wave velocity (PWV), that differ from youth without Down syndrome and to compare reference-based age-adjusted (age-PWV-Z) and height-adjusted (Ht-PWV-Z) in youth with and without Down syndrome. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 11, 2019 Category: Pediatrics Authors: Andrea Kelly, Sheela N. Magge, Rachel Walega, Claire Cochrane, Mary E. Pipan, Babette S. Zemel, Meryl S. Cohen, Samuel S. Gidding, Ray Townsend Tags: Original Article Source Type: research

Neonatal Antibiotics and Prematurity Are Associated with an Increased Risk of Functional Gastrointestinal Disorders in the First Year of Life
To assess the prevalence of functional gastrointestinal disorders (FGIDs) in the first year of life and the influence of different neonatal factors on development of FGIDs. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 11, 2019 Category: Pediatrics Authors: Silvia Salvatore, Maria Elisabetta Baldassarre, Antonio Di Mauro, Nicola Laforgia, Silvio Tafuri, Francesco Paolo Bianchi, Enzo Dattoli, Lucia Morando, Licia Pensabene, Fabio Meneghin, Dario Dilillo, Valentina Mancini, Valentina Talarico, Francesco Tandoi Tags: Original Article Source Type: research

Pustular Eruption in Kawasaki Disease
A 4-year-old previously healthy boy presented to the emergency department for evaluation of 5 days of fever and 6 days of diffuse pustular rash. Three days prior, he had been evaluated by his pediatrician and started on azithromycin for streptococcal infection, diagnosed by positive rapid streptococcal testing. Dermatology was consulted to evaluate for possible acute generalized exanthematous pustulosis (AGEP). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 11, 2019 Category: Pediatrics Authors: Sonia Kamath, Emily A. Gurnee, Olivia L. Schenck, Sarah L. Chamlin, Anthony J. Mancini Tags: Rediscovering the Physical Exam Source Type: research