Implementation of a Rapid Evidence Assessment Infrastructure during the COVID-19 Pandemic to Develop Policies, Clinical Pathways, Stimulate Academic Research, and Create Educational Opportunities
In early 2020, hospitals across the United States, including Children ’s Hospital Colorado (CHCO), began preparing for the regional impact of the SARS-CoV-2 pandemic via an Incident Command Team (ICT)--a unified approach to hospital operations including the command, control, and coordination of incident management (1-3). The ICT at CHCO recognized the need for a sci entific partnership for rapid uptake and synthesis of quickly accruing medical and public health literature to inform institutional policies and clinical care. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - October 19, 2020 Category: Pediatrics Authors: Suchitra Rao, Bethany M. Kwan, Donna Curtis, Angela Swanson, Leigh Anne Bakel, Lalit Bajaj, Juri Boguniewicz, Justin Lockwood, Kaleigh Ogawa, Pemberton Katherine, Robert C. Fuhlbrigge, David Brumbaugh, Patricia Givens, Eva Nozik Grayck, Marion R. Sills Tags: AMSPDC Source Type: research

The Impact of Primary Mentors and Career Development Committees on Junior Faculty Productivity in a Pediatric Academic Health Center
Access to quality mentorship is an important factor in determining junior faculty members ’ career development, job satisfaction, and success, as well as a key component of institutions’ endeavors to build the next generation of diverse faculty members and leaders in academic medicine. 1-7 However, few studies have rigorously evaluated the longitudinal association between mentorship initiatives and measures of academic productivity such as manuscripts and grants. 8,9 Furthermore, little is known about the effectiveness of mentorship programs by sex or academic track (eg, clinical vs research) among academic fac...
Source: The Journal of Pediatrics - October 19, 2020 Category: Pediatrics Authors: Jamilah M. Hackworth, Jareen Meinzen-Derr, Mallory DePalma, Margaret Hostetter, Melissa Klein, Jennifer K. O ’Toole, Jessica Kahn Source Type: research

Declines in the number of Lumbar Punctures performed at U.S. Children ’s Hospitals: 2009-2019
to evaluate trends in LP performance among U.S. children ’s hospitals to assess how risk stratification algorithms impact pediatric resident trainee exposure to lumbar puncture (LP). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - October 17, 2020 Category: Pediatrics Authors: Alexandra T. Geanacopoulos, John J. Porter, Kenneth A. Michelson, Rebecca S. Green, Vincent W. Chiang, Michael C. Monuteaux, Mark I. Neuman Tags: Original Articles Source Type: research

Development and Validation of a Model to Predict Neonatal Abstinence Syndrome
To develop and validate clinical risk prediction tools for neonatal abstinence syndrome (NAS). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - October 16, 2020 Category: Pediatrics Authors: Stephen W. Patrick, James C. Slaughter, Frank E. Harrell, Peter R. Martin, Katherine Hartmann, Judith Dudley, Shannon Stratton, William O. Cooper Tags: Original Articles Source Type: research

Multisystem Inflammatory Syndrome in Children: Survey of Protocols for Early Hospital Evaluation and Management
To describe the similarities and differences in the evaluation and treatment of multisystem inflammatory syndrome in children (MIS-C) at hospitals in the United States. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - October 16, 2020 Category: Pediatrics Authors: Matthew L. Dove, Preeti Jaggi, Michael Kelleman, Mayssa Abuali, Jocelyn Y. Ang, Wassim Ballan, Sanmit K. Basu, M. Jay Campbell, Sathish M. Chikkabyrappa, Nadine F. Choueiter, Katharine N. Clouser, Daniel Corwin, Amy Edwards, Shira J. Gertz, Rod Ghassemzad Tags: Original Articles Source Type: research

Hepatitis C in Young Children: To Treat or Not to Treat – Is It Cost-Effective?
Chronic hepatitis C virus (HCV) infection, one of the most important public health problems in modern medicine, is responsible for approximately 71 million infections worldwide. The global disease burden of children with HCV infection aged 0-18 years old is estimated to be 0.13%, corresponding to 3.26 million children.1 In 2018, the prevalence of Hchildren with HCV infection in the United States and Europe was estimated to be 0.05%-0.36%.2 (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - October 15, 2020 Category: Pediatrics Authors: Norberto Rodriguez-Baez Tags: Editorials Source Type: research

A Pilot Randomized Controlled Trial of Early Targeted Patent Ductus Arteriosus Treatment Using a Risk Based Severity Score (The PDA RCT)
To evaluate the feasibility of recruiting preterm infants to a randomized controlled trial of patent ductus arteriosus (PDA) treatment based on a PDA severity score (PDAsc) and to characterize challenges in obtaining consent, compliance with the protocol, and PDA closure rates. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - October 15, 2020 Category: Pediatrics Authors: Afif EL-Khuffash, Neid ín Bussmann, Colm R. Breatnach, Aisling Smith, Elizabeth Tully, Joanna Griffin, Naomi McCallion, John David Corcoran, Elena Fernandez, Claudia Looi, Brian Cleary, Orla Franklin, Patrick J. McNamara Tags: Original Articles Source Type: research

Development and Assessment of a Pictographic Pediatric Constipation Action Plan
To assess the Uniformed Services Constipation Action Plan (USCAP) as an evidence-based, personalized, clinical action tool with pictograms to aid clinicians and families in the management of functional constipation. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - October 14, 2020 Category: Pediatrics Authors: Patrick T. Reeves, Nathan T. Kolasinski, H. Shonna Yin, Sofia Echelmeyer, Bruno P. Chumpitazi, Philip Rogers, Carolyn Sullivan Burklow, Cade M. Nylund Tags: Original Articles Source Type: research

A Battery of Easily Accessible, Simple Tools for the Assessment of Concussion in Children
Abstract (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - October 14, 2020 Category: Pediatrics Authors: William D. Brown, Janette Baird, Peter K. Kriz Tags: Original Articles Source Type: research

Family Experiences Deciding For and Against Pediatric Home Ventilation
To understand what considerations drive family decisions for, and against, pediatric home ventilation. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - October 14, 2020 Category: Pediatrics Authors: Renee D. Boss, Carrie M. Henderson, Jessica C. Raisanen, Nicholas A. Jabre, Kelly Shipman, Benjamin S. Wilfond Tags: Original Articles Source Type: research

One Size Does Not Fit All: Implementation of an Equitable and Inclusive Strategic Response to Address Needs of Pediatric Resident Physicians during the COVID-19 Crisis
The Coronavirus disease 2019 (COVID-19) crisis has the potential to amplify an already unequal stress on resident physicians who belong to groups underrepresented in medicine (based on race, ethnicity, socioeconomic status, LGBTQIA+ identity, or disability).1,2,3 These groups experience challenges in residency training, including incidences of microaggressions and bias; feelings of isolation; and personal, professional, and financial hardships, all of which may be exacerbated in times of crisis. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - October 14, 2020 Category: Pediatrics Authors: Marcella Luercio, Valerie L. Ward, Theodore C. Sectish, Camila M. Mateo, Catherine D. Michelson Tags: AMSPDC Source Type: research

Outcomes After Introduction of Minimally Invasive Surfactant Therapy in Two Australian Tertiary Neonatal Units
To assess the procedural and clinical outcomes associated with the introduction of minimally invasive surfactant therapy (MIST) into standard care at two tertiary Australian neonatal intensive care units. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - October 14, 2020 Category: Pediatrics Authors: Calum T. Roberts, Ikhwan Halibullah, Risha Bhatia, Elys A. Green, C. Omar F. Kamlin, Peter G. Davis, Brett J. Manley Tags: Original Articles Source Type: research

Discriminating MIS-C Requiring Treatment from Common Febrile Conditions in Outpatient Settings
To examine whether patients with multisystem inflammatory syndrome in children (MIS-C) demonstrated well-defined clinical features distinct from other febrile outpatients given the difficulties of seeing acute care visits during the SARS-CoV-2 pandemic and the risks associated with both over and underdiagnosis of MIS-C. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - October 13, 2020 Category: Pediatrics Authors: Rebecca F. Carlin, Avital M. Fischer, Zachary Pitkowsky, Dori Abel, Taylor B. Sewell, Erika Grun Landau, Steve Caddle, Laura Robbins-Milne, Alexis Boneparth, Josh D. Milner, Eva W. Cheung, Philip Zachariah, Melissa S. Stockwell, Brett R. Anderson, Mark Go Tags: Original Articles Source Type: research

Survival and Developmental Outcomes of Neonates Treated with Extracorporeal Membrane Oxygenation: A 10-year Single Center Experience
To evaluate the associations between the primary indication for ECMO in neonates and neurodevelopmental outcomes at 12 and 24 months of age. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - October 12, 2020 Category: Pediatrics Authors: Faith Kim, Judy Bernbaum, James Connelly, Marsha Gerdes, Holly Hedrick, Casey Hoffman, Natalie Rintoul, Kristina Ziolkowski, Sara B. DeMauro Tags: Original Articles Source Type: research

Outcomes of Infants with Very Low Birth Weight Associated with Birthplace Difference: A Retrospective Cohort Study of Births in Japan and California
To determine whether outcomes among infants with very low birth weight (VLBW) vary according to the birthplace (Japan or California) controlling for maternal ethnicity. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - October 12, 2020 Category: Pediatrics Authors: Satoshi Kusuda, Mihoko Bennett, Jeffrey Gould, Neonatal Research Network of Japan and the California Perinatal Quality Care Collaborative Tags: Original Articles Source Type: research

The Dark Side of the Web —A Risk for Children and Adolescents Challenged by Isolation during the COVID-19 Pandemic
In response to the global pandemic of COVID-19, many countries around the world adopted social isolation measures to contain the spread of the virus1. For children and adolescents, limitations in face-to-face activities and interactions with their traditional peer groups has been a frustrating experience. Following disease containment measures, which included school closures, social distancing, and home quarantine, children and adolescents faced a prolonged state of physical isolation from their peers, teachers, extended family, and community networks that affects their emotional and behavioral health2. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - October 10, 2020 Category: Pediatrics Authors: Pietro Ferrara, Giulia Franceschini, Giovanni Corsello, Julije Mestrovic, Ida Giardino, Mehmet Vural, Tudor Lucian Pop, Leyla Namazova-Baranova, Massimo Pettoello-Mantovani Source Type: research

Corrigendum
Discussion section. The correct sentence should read “In this retrospective 2-center study, we found that 47% of our patients demonstrated a different ABPM phenotype on follow up study.” (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - October 9, 2020 Category: Pediatrics Tags: Correction Source Type: research

Antibiotic Choice and Clinical Outcomes in Ambulatory Children with Community-Acquired Pneumonia
To describe antibiotic prescribing patterns in ambulatory children with community acquired pneumonia, and to assess the relationship between antibiotic selection and clinical outcomes. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - October 9, 2020 Category: Pediatrics Authors: Susan C. Lipsett, Matthew Hall, Lilliam Ambroggio, Adam L. Hersh, Samir S. Shah, Thomas V. Brogan, Jeffrey S. Gerber, Derek J. Williams, Carlos G. Grijalva, Anne J. Blaschke, Mark I. Neuman Tags: Original Articles Source Type: research

Comparison of Clinical and Epidemiologic Characteristics of Young Febrile Infants with and without SARS-CoV-2 Infection
To determine features that distinguish febrile young infants with SARS-CoV-2 infection. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - October 8, 2020 Category: Pediatrics Authors: Jill Leibowitz, William Krief, Stephen Barone, Kristy A. Williamson, Pratichi K. Goenka, Shipra Rai, Shannon Moriarty, Prachi Baodhankar, Lorry G. Rubin Tags: Original Articles Source Type: research

Bilateral Congenital Dislocation of the Knee
A female infant was delivered at 39 weeks of gestation via cesarean delivery because of non-reassuring fetal status. Prenatal sonography performed one week prior to the delivery revealed oligohydramnios. Post-delivery, both knees of the infant were hyperextended with no other anomalies (Figure 1). Radiography of both knees showed posterior dislocation of the femur on the tibia (Figure 2). Hence, the bilateral congenital dislocation of the knee was diagnosed. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - October 8, 2020 Category: Pediatrics Authors: Tomohiro Hirade, Kousuke Katsube, Fumihide Kato Tags: Rediscovering the Physical Exam Source Type: research

Year-round, Routine Testing of Multiple Body Site Specimens for Human Parechovirus in Young Febrile Infants
To test our hypothesis that routine year-round testing of specimens from multiple body sites and genotyping of detected virus would describe seasonal changes, increase diagnostic yield and provide a better definition of clinical manifestations of human parechovirus (PeV-A) infections in young febrile infants. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - October 8, 2020 Category: Pediatrics Authors: Cristina Tomatis Souverbielle, Huanyu Wang, John Feister, Jason Campbell, Alexandra Medoro, Asuncion Mejias, Octavio Ramilo, Domenico Pietropaolo, Douglas Salamon, Amy Leber, Guliz Erdem Tags: Original Articles Source Type: research

Improvement in the Prediction of Neonatal Hypoxicischemic Encephalopathy with the Integration of Umbilical Cord Metabolites and Current Clinical Makers
To validate our previously identified candidate metabolites, and to assess the ability of these metabolites to predict hypoxic-ischemic encephalopathy (HIE) both individually and combined with clinical data. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - October 7, 2020 Category: Pediatrics Authors: Daragh S. O ’Boyle, Warwick B. Dunn, Donna O’Neill, Jennifer A. Kirwan, David I. Broadhurst, Boubou Hallberg, Geraldine B. Boylan, Deirdre M. Murray Tags: Original Articles Source Type: research

Fish Oil Emulsion Reduces Liver Injury and Liver transplantation in Children with Intestinal Failure-Associated Liver Disease: A Multicenter Integrated Study
To compare aminotransferase with platelet ratio index (APRI), liver transplantation, and mortality rates between children with intestinal failure-associated liver disease (IFALD) who received fish oil lipid emulsion (FOLE) or soybean oil lipid emulsion (SOLE). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - October 6, 2020 Category: Pediatrics Authors: Kathleen M. Gura, Muralidhar H. Premkumar, Kara L. Calkins, Mark Puder Tags: Original Articles Source Type: research

Mucolipidosis II
A term male infant, born to a 20-year-old primigravida, was admitted for respiratory distress. A prenatal ultrasound showed shortened long bones. The parents were orthodox Jews and there was history of second degree consanguinity. A deceased paternal cousin was diagnosed with mucolipidosis. Birthweight (2175 g), length and head circumference were below the third percentile. On physical examination, he had prominent forehead with large fontanelle, low set ears, prominent eyes, telecanthus, maxillary hypoplasia, gingival hyperplasia, narrow chest, distended abdomen, short limbs, bowing of the lower extremities and generalize...
Source: The Journal of Pediatrics - October 6, 2020 Category: Pediatrics Authors: Ranjit I. Kylat Tags: Insights and Images Source Type: research

Association of Anemia with Neurodevelopmental Disorders in A Nationally Representative Sample of US Children
To examine the association of anemia with autism spectrum disorder (ASD), attention deficit/hyperactivity disorder (ADHD), and learning disability in US children. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - October 5, 2020 Category: Pediatrics Authors: Wenhan Yang, Buyun Liu, Rui Gao, Linda G. Snetselaar, Lane Strathearn, Wei Bao Tags: Original Articles Source Type: research

Asymmetric overgrowth and a facial port-wine stain
A 3-month-old female infant presented with generalized marbling of the skin (cutis marmorata) and a striking port-wine stain on the philtrum present since birth. A bilateral sandal gap between the great and second toes, macrodactyly of the left second toe, overgrowth of both feet, hands, and her right leg as well as joint hypermobility were noted. Upon physical and neurological examination, including measurement of head circumference, no other pathologic findings were observed. Cranial, spinal, abdominal and hip ultrasound, echocardiography, ophthalmologic exam, and otoacoustic emissions testing were unremarkable. (Source:...
Source: The Journal of Pediatrics - October 4, 2020 Category: Pediatrics Authors: Peter Seiringer, Tilo Biedermann, Christina Schnopp Tags: Rediscovering the Physical Exam Source Type: research

Trajectories in Neurodevelopmental, Health-Related Quality of Life, and Functional Status Outcomes by Socioeconomic Status and Maternal Education in Children with Single Ventricle Heart Disease
Trajectories of neurodevelopment and quality of life were analyzed in children with hypoplastic left heart syndrome according to socioeconomic status and maternal education. Lower socioeconomic status and maternal education were associated with greater early delays in communication and problem-solving and progressive delays in problem-solving and fine motor skills over time. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - October 4, 2020 Category: Pediatrics Authors: Emily M. Bucholz, Lynn A. Sleeper, Renee Sananes, Cheryl L. Brosig, Caren S. Goldberg, Sara K. Pasquali, Jane W. Newburger Tags: Brief Reports Source Type: research

Hospitalization Outcomes for Rural Children with Mental Health Conditions
To identify where rural children with mental health conditions are hospitalized and to determine differences in outcomes based upon location of hospitalization. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 29, 2020 Category: Pediatrics Authors: Jessica L. Bettenhausen, Matt Hall, Stephanie K. Doupnik, Jessica L. Markham, James Feinstein, Jay Berry, James C. Gay Tags: Original Articles Source Type: research

Longitudinal B-Type Natriuretic Peptide Levels Predict Outcome in Infants with Congenital Diaphragmatic Hernia
To evaluate B-type natriuretic peptide (BNP) as a longitudinal biomarker of clinical outcome in infants with congenital diaphragmatic hernia (CDH). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 25, 2020 Category: Pediatrics Authors: Elyssa Guslits, Martina A. Steurer, Hythem Nawaytou, Roberta L. Keller Tags: Original Articles Source Type: research

RNA is not Virus
Yonker et al demonstrated high levels of viral RNA in nasopharyngeal samples obtained from children.1 (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 23, 2020 Category: Pediatrics Authors: Gregory I. Sawchyn Tags: Letters to the Editor Source Type: research

Reply
In our article, we report high viral load in children infected with SARS-CoV-2 in the first two days of illness. We did not assess viability of virus from these respiratory secretions and agree that RNA does not necessarily correlate with live virus. However, in hospitalized adults, live virus is readily cultured from respiratory secretions during the first week of symptoms.2 It is plausible that differences exists between pediatric and adult immune responses to SARS-CoV-23; distinctions in mucosal immune responses could impact viral detection by RT-PCR and/or severity of symptoms. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 23, 2020 Category: Pediatrics Authors: Lael M. Yonker, Alessio Fasano Tags: Letters to the Editor Source Type: research

Congenital Heart Defects and the Risk of Spontaneous Preterm Birth
To estimate the association between major types of congenital heart defects (CHD) and spontaneous preterm birth, and to assess the potential underlying mechanisms. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 23, 2020 Category: Pediatrics Authors: Niels B. Matthiesen, John R. Østergaard, Vibeke E. Hjortdal, Tine B. Henriksen Tags: Original Articles Source Type: research

Practical School Algorithms for Symptomatic or SARS-CoV-2-Exposed Students Are Essential for Returning Children to In-Person Learning
The coronavirus disease 2019 (COVID-19) pandemic has significantly impacted the well-being of children as a result of the widespread closure of schools. Throughout the summer, states have allowed the reopening of many businesses including restaurants, bars, retail locations, and amusement parks, including in locations experiencing surges in cases. Meanwhile, many school districts across the country began the fall semester in a partially or completely virtual fashion. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 23, 2020 Category: Pediatrics Authors: Rachel C. Orscheln, Jason G. Newland, David A. Rosen Tags: Commentary Source Type: research

Kawasaki Disease and Clinical Outcome Disparities among Black Children
ICD codes were used to identify children with Kawasaki disease admitted to a tertiary Southeast U.S. center. Subjects diagnosed and treated according to AHA criteria were included. Demographic, laboratory, clinical and echocardiographic data from EMR (2000-2015) were compared between Blacks and Whites. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 22, 2020 Category: Pediatrics Authors: Luz A. Padilla, Jacqueline L. Collins, Adeniyi J. Idigo, Yung Lau, Michael A. Portman, Sadeep Shrestha Tags: Original Articles Source Type: research

Outcomes in Patients with Alagille Syndrome and Complex Pulmonary Artery Disease
To assess outcomes in a large cohort of patients with Alagille Syndrome (ALGS) who underwent pulmonary artery reconstruction surgery for complex PA disease. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 22, 2020 Category: Pediatrics Authors: Roger Luong, Jeffrey A. Feinstein, Michael Ma, Noelle H. Ebel, Lisa Wise-Faberowski, Yulin Zhang, Lynn F. Peng, Vamsi V. Yarlagadda, Jennifer Shek, Frank L. Hanley, Doff B. McElhinney Tags: Original Articles Source Type: research

Costs of Neonatal Intensive Care for Canadian Infants with Preterm Birth
Data supporting the findings of this study are available from the corresponding author upon reasonable request. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 22, 2020 Category: Pediatrics Authors: Juan D. Rios, Prakesh S. Shah, Marc Beltempo, Deepak Louis, Amit Mukerji, Shahirose Premji, Vibhuti Shah, Shoo K. Lee, Petros Pechlivanoglou, Canadian Preterm Birth Network Investigators, Canadian Neonatal Network Investigators Tags: Original Articles Source Type: research

Establishing a Mentoring Culture within the Department: The Role of the Chair
The academic medicine literature supports the positive impact of mentoring partnerships for faculty; these include enhanced clinical care, teaching, scholarship, leadership development, career satisfaction, promotion, and retention.1-3 Choi et  al proposed that “a dynamic culture of mentorship is essential to the success of academic medical centers and should be elevated to the level of a major strategic priority.”4 (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 22, 2020 Category: Pediatrics Authors: Jennifer K. Giancola, Barbara Whitman, Robert W. Wilmott Tags: Notes from the Association of Medical School Pediatric Department Chairs, Inc. Source Type: research

50 Years Ago in The Journal of Pediatrics
Freeman JM. Neonatal seizures –diagnosis and management. J Pediatr 1970;77:701-708. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 22, 2020 Category: Pediatrics Authors: Jannicke H. Andresen, Ola Didrik Saugstad Tags: Original Article Source Type: research

50 Years Ago in The Journal of Pediatrics
Rosen EU, Campbell PG, Moosa GM. Hypomagnesemia and magnesium protein-calorie malnutrition. J Pediatr 1970;77:709. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 22, 2020 Category: Pediatrics Authors: Aaradhana Singh, Piyush Gupta Tags: Original Article Source Type: research

50 Years Ago in The Journal of Pediatrics
Derrick CW, Dillon HC. Further studies on the treatment of streptococcal skin infections. J Pediatr 1970;27:696-700. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 22, 2020 Category: Pediatrics Authors: Sarah S. Long Tags: Original Article Source Type: research

50 Years Ago in The Journal of Pediatrics
Winkelstein JA. The Influence of Partial Treatment with Penicillin in the Diagnosis of Bacterial Meningitis. J Pediatr 1970;77:619-24. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 22, 2020 Category: Pediatrics Authors: Brenda I. Anosike, Betsy C. Herold Tags: Original Article Source Type: research

50 Years Ago in The Journal of Pediatrics
Freeman JM. Neonatal seizures –diagnosis and management. J Pediatr 1970;77:701-8. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 22, 2020 Category: Pediatrics Authors: Jannicke H. Andresen, Ola Didrik Saugstad Tags: Original Article Source Type: research

50 Years Ago in The Journal of Pediatrics
Lifshitz F, Coello-Ram írez P, Gutiérrez-Topete G. Monosaccharide intolerance and hypoglycemia in infants with diarrhea I. Clinical course of 23 infants. J Pediatr 1970;77:595-603. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 22, 2020 Category: Pediatrics Authors: A. Adjowa Amevor, Stephanie B. Oliveira Tags: Original Article Source Type: research

50 Years Ago in The Journal of Pediatrics
Weinberg S. Suicidal Intent in Adolescence: A Hypothesis about the Role of Physical Illness. J Pediatr 1970:77:579-86. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 22, 2020 Category: Pediatrics Authors: Sharon C. Enujioke, Mary A. Ott Tags: Original Article Source Type: research

50 Years Ago in The Journal of Pediatrics
Hurwitz S, Irwin B. White Spots in Tuberous Sclerosis. J Pediatr 1970;77:587-94. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 22, 2020 Category: Pediatrics Authors: Amanda G. Sandoval Karamian Tags: Original Article Source Type: research

Using QI to break bad habits
When you take your car to Meineke, chances are you will get a muffler. Well, it seems when you take children to the emergency department or an urgent care center for abdominal pain due to constipation, chances are they will get an abdominal x-ray (AXR). Children discharged with a diagnosis of constipation account for up to 25% of cases seen in some emergency departments or urgent care centers, and as many as 30%-90% will have an AXR as part of their evaluation. Evidenced-based guidelines for the “Evaluation and Treatment of Functional Constipation in Infants and Children” published jointly by the North American...
Source: The Journal of Pediatrics - September 22, 2020 Category: Pediatrics Authors: Ivor D. Hill Tags: The Editors' Perspectives Source Type: research

A “handy” reminder
Because of the long-term risk of neurodevelopmental impairments, many neonatal intensive care unit (NICU) graduates receive developmental surveillance in high risk infant follow up programs. There are no national recommendations for the duration of follow up but a survey published in 2014 (J Perinatol 2014;34:71-74) showed that programs rarely extend through 5 years of age. A longitudinal study of extremely preterm children published this month in The Journal of Pediatrics reminds us that longer follow up may be necessary for many children. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 22, 2020 Category: Pediatrics Authors: Raye-Ann deRegnier Tags: The Editors' Perspectives Source Type: research

Repeated clinical assessments surpass a laboratory test screening approach for early onset sepsis
Frymoyer et al report the second, sustainability phase of a quality improvement initiative that was begun 5 years earlier at the Lucile Packard Children ’s Hospital at Stanford. The initiative replaces the approach of screening laboratory tests and empiric antibiotic treatment for infants at perceived risk for early onset sepsis (EOS) with a solely clinical approach. Managing>20 000 neonates born at>35 weeks ’ gestation over the intervention and sustainability phases, laboratory testing and ampicillin use declined substantially in phase 1, was sustained in phase 2, and the approach was safe. (Source: The ...
Source: The Journal of Pediatrics - September 22, 2020 Category: Pediatrics Authors: Sarah S. Long Tags: The Editors' Perspectives Source Type: research

The importance of genotype in understanding phenotype —The example of pulmonary arterial hypertension
With continued advances, it is becoming clear that pulmonary arterial hypertension in children is a heterogeneous disease, and distinct from the same syndrome in adults. In this volume of The Journal the work of Haarman et al underscores both the differences and their importance. Using a national cohort of children with pulmonary arterial hypertension from a Dutch national registry they describe detailed genotype and phenotype descriptions for 70 children (Figure). Importantly the most common genetic variant was in TBX4, compared with adults where BMPR2 is most common. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 22, 2020 Category: Pediatrics Authors: Denise M. Goodman Tags: The Editors' Perspectives Source Type: research

Improving NICU outcomes –A worldwide endeavor
In this volume of The Journal, D ’Apremont et al report on mortality and morbidity outcomes over 15 years (2001-2016) for nearly 14 000 very low birthweight infants (500-1500 grams) at NEOCOSUR centers (30 Neonatal Units from Argentina, Brazil, Chile, Paraguay, Peru, and Uruguay). While many national and international NICU collec tives from the US, Canada, Europe, Australia, and Japan have published large scale NICU outcome data, D’Apremont et al provide the first substantial multi-year report from a similar NICU collaborative based in middle-income countries. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - September 22, 2020 Category: Pediatrics Authors: Robin H. Steinhorn Tags: The Editors' Perspectives Source Type: research