Three plasma metabolites in elderly patients differentiate mild cognitive impairment and Alzheimer's disease: a pilot study.
Authors: Costa AC, Joaquim HPG, Forlenza OV, Gattaz WF, Talib LL Abstract The metabolomic profile of patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) may suggest potential diagnostic biomarkers and provide information on the pathophysiology of dementia. Our aim was to quantify plasmatic metabolites of AD patients, MCI and controls. We investigated the metabolomic profile-using the AbsoluteIDQ®p180 assay-of 79 older adults with primary cognitive impairment (34 AD and 20 MCI) and 25 healthy elders (controls). A cluster analysis revealed that a combination C12-DC, C12 and PCaaC26:0 could ...
Source: European Archives of Psychiatry and Clinical Neuroscience - June 22, 2019 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Neurocognitive functioning in patients with first-episode schizophrenia: results of a prospective 15-year follow-up study.
Authors: Albus M, Hubmann W, Mohr F, Tiedemann TV, Pechler S, Drießlein D, Küchenhoff H Abstract To evaluate the course of neuropsychological impairment, patients with first-episode schizophrenia and healthy controls were assessed with a comprehensive test battery at the time of index treatment and after a 5- and 15-year follow-up period. Summary scores for verbal intelligence (VBI), spatial organization, verbal fluency, verbal learning, semantic memory, visual memory, delay/retention rate, short-term memory, visual-motor processing and attention (VSM) and abstraction/flexibility were constructed. Our re...
Source: European Archives of Psychiatry and Clinical Neuroscience - June 21, 2019 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Three plasma metabolites in elderly patients differentiate mild cognitive impairment and Alzheimer ’s disease: a pilot study
AbstractThe metabolomic profile of patients with Alzheimer ’s disease (AD) and mild cognitive impairment (MCI) may suggest potential diagnostic biomarkers and provide information on the pathophysiology of dementia. Our aim was to quantify plasmatic metabolites of AD patients, MCI and controls. We investigated the metabolomic profile—using the AbsoluteID Q®p180 assay—of 79 older adults with primary cognitive impairment (34 AD and 20 MCI) and 25 healthy elders (controls). A cluster analysis revealed that a combination C12-DC, C12 and PCaaC26:0 could differentiate the patients according to diagnostic. Fu...
Source: European Archives of Psychiatry and Clinical Neuroscience - June 19, 2019 Category: Neuroscience Source Type: research

Neurocognitive functioning in patients with first-episode schizophrenia: results of a prospective 15-year follow-up study
AbstractTo evaluate the course of neuropsychological impairment, patients with first-episode schizophrenia and healthy controls were assessed with a comprehensive test battery at the time of index treatment and after a 5- and 15-year follow-up period. Summary scores for verbal intelligence (VBI), spatial organization, verbal fluency, verbal learning, semantic memory, visual memory, delay/retention rate, short-term memory, visual –motor processing and attention (VSM) and abstraction/flexibility were constructed. Our results show that neurocognitive functioning is impaired already at the onset of schizophrenia and rema...
Source: European Archives of Psychiatry and Clinical Neuroscience - June 18, 2019 Category: Neuroscience Source Type: research

When does shared decision making is adopted in psychiatric clinical practice? Results from a European multicentric study.
Authors: Luciano M, Sampogna G, Del Vecchio V, Loos S, Slade M, Clarke E, Nagy M, Kovacs A, Munk-Jørgensen P, Krogsgaard Bording M, Kawohl W, Rössler W, Puschner B, Fiorillo A, CEDAR Study Group Abstract To identify factors associated with the use of shared decision making in routine mental health care in a large multicenter European study. Data have been collected within the study "Clinical decision making and outcome in routine care for people with severe mental illness" (CEDAR), which is a naturalistic, longitudinal, observational study carried out in six European countries. Patients with a...
Source: European Archives of Psychiatry and Clinical Neuroscience - June 9, 2019 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Cannabidiol: a hope to treat non-motor symptoms of Parkinson's disease patients.
Authors: Saleem S, Anwar A PMID: 31168642 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - June 8, 2019 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Borderline personality disorder: from understanding ontological addiction to psychotherapeutic revolution.
Authors: Ducasse D, Van Gordon W, Brand-Arpon V, Courtet P, Olié E Abstract Bypassing a reductionist view of existing diagnostic categories, ontological addiction theory (OAT) is a new psychological model of human functioning. Borderline Personality Disorder (BPD), defined as "a pattern of instability in interpersonal relationships, self-image and affects, and marked impulsivity", is not only common (up to 20% of psychiatric inpatients), but also strongly associated with suicide attempts and death by suicide. Therefore, BPD constitutes a major public health concern. As a consequence of an underlyin...
Source: European Archives of Psychiatry and Clinical Neuroscience - June 7, 2019 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

When does shared decision making is adopted in psychiatric clinical practice? Results from a European multicentric study
AbstractTo identify factors associated with the use of shared decision making in routine mental health care in a large multicenter European study. Data have been collected within the study “Clinical decision making and outcome in routine care for people with severe mental illness” (CEDAR), which is a naturalistic, longitudinal, observational study carried out in six European countries. Patients with a severe mental illness attending outpatient units and their treating clinicians h ave been recruited. Clinicians’ Clinical Decision Making (CDM) styles have been explored through the Clinical Decision Making ...
Source: European Archives of Psychiatry and Clinical Neuroscience - June 7, 2019 Category: Neuroscience Source Type: research

Migration and schizophrenia: meta-analysis and explanatory framework.
Authors: Henssler J, Brandt L, Müller M, Liu S, Montag C, Sterzer P, Heinz A Abstract Systematic reviews and meta-analyses suggest that there are increased rates of schizophrenia and related psychoses in first- and second-generation migrants and refugees. Here, we present a meta-analysis on the incidence of non-affective psychotic disorders among first- and second-generation migrants. We found substantial evidence for an increased relative risk of incidence among first- and second-generation migrants compared to the native population. As heterogeneity of included studies was high, effect estimates should be in...
Source: European Archives of Psychiatry and Clinical Neuroscience - June 5, 2019 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Cannabidiol: a hope to treat non-motor symptoms of Parkinson's disease patients
(Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - June 5, 2019 Category: Neuroscience Source Type: research

Migration and schizophrenia: meta-analysis and explanatory framework
AbstractSystematic reviews and meta-analyses suggest that there are increased rates of schizophrenia and related psychoses in first- and second-generation migrants and refugees. Here, we present a meta-analysis on the incidence of non-affective psychotic disorders among first- and second-generation migrants. We found substantial evidence for an increased relative risk of incidence among first- and second-generation migrants compared to the native population. As heterogeneity of included studies was high, effect estimates should be interpreted with caution and as guiding values rather than exact risk estimates. We interpret...
Source: European Archives of Psychiatry and Clinical Neuroscience - June 4, 2019 Category: Neuroscience Source Type: research

Borderline personality disorder: from understanding ontological addiction to psychotherapeutic revolution
AbstractBypassing a reductionist view of existing diagnostic categories, ontological addiction theory (OAT) is a new psychological model of human functioning. Borderline Personality Disorder (BPD), defined as “a pattern of instability in interpersonal relationships, self-image and affects, and marked impulsivity”, is not only common (up to 20% of psychiatric inpatients), but also strongly associated with suicide attempts and death by suicide. Therefore, BPD constitutes a major public health concern. As a consequence of an underlying condition of ontological addiction, self-harming behaviors can be conceptualize...
Source: European Archives of Psychiatry and Clinical Neuroscience - June 4, 2019 Category: Neuroscience Source Type: research

Correction to: New trends in  cannabis potency in USA and Europe during the last decade (2008-2017).
Correction to: New trends in cannabis potency in USA and Europe during the last decade (2008-2017). Eur Arch Psychiatry Clin Neurosci. 2019 May 23;: Authors: Chandra S, Radwan MM, Majumdar CG, Church JC, Freeman TP, ElSohly MA Abstract In the original publication, table 2 contained data that should not have been included in table 2 and also was not discussed in the body of the manuscript. PMID: 31123822 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - May 29, 2019 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Neurological soft signs and neurocognitive deficits in remitted patients with schizophrenia, their first-degree unaffected relatives, and healthy controls.
This study aimed to explore the NSS and ND and examine the comparative relationship between them in RP, their first-degree unaffected relatives (FDR), and healthy controls, furthermore, to seek potential endophenotypes subitems of NSS and ND and create a composite endophenotype. 86 RP, 86 FDR, and 86 healthy controls were included. NSS and ND were independently assessed with Cambridge Neurological Inventory and MATRICSTM Consensus Cognitive Battery. RP had more NSS and ND than FDR in all subitems except disinhibition, information processing speed, working memory, and visual memory. Similarly, FDR presented poorer performan...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 29, 2019 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Schizophrenia-spectrum psychopathology in obsessive-compulsive disorder: an empirical study.
In conclusion, a high proportion of clinically diagnosed OCD patients fulfilled diagnostic criteria of a schizophrenia-spectrum disorder. The conspicuous obsessive-compulsive symptomatology may have resulted in a disregard of psychotic symptoms and other psychopathology. Furthermore, the differentiation of obsessions from related psychopathological phenomena is insufficient and a conceptual and empirical effort in this domain is required in the future. PMID: 31129700 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - May 29, 2019 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Psychiatric symptoms and quality of life in older adults with schizophrenia spectrum disorder: results from a multicenter study.
Authors: Hoertel N, Rotenberg L, Blanco C, Pascal de Raykeer R, Hanon C, Kaladjian A, Limosin F, CSA Study Group Abstract The severity of psychopathology has a strong negative impact on quality of life (QoL) among older adults with schizophrenia spectrum disorder. However, because these subjects generally experience multiple psychiatric symptoms, it remains unclear whether decreased QoL in this population is due to specific symptoms (e.g., hallucinations), specific dimensions of psychopathology (e.g., negative symptoms), a general psychopathology dimension representing the shared effect across all psychiatric sympt...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 29, 2019 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Psychiatric symptoms and quality of life in older adults with schizophrenia spectrum disorder: results from a multicenter study
AbstractThe severity of psychopathology has a strong negative impact on quality of life (QoL) among older adults with schizophrenia spectrum disorder. However, because these subjects generally experience multiple psychiatric symptoms, it remains unclear whether decreased QoL in this population is due to specific symptoms (e.g., hallucinations), specific dimensions of psychopathology (e.g., negative symptoms), a general psychopathology dimension representing the shared effect across all psychiatric symptoms, or a combination of these explanations. Data were derived from the Cohort of individuals with Schizophrenia Aged 55 &...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 27, 2019 Category: Neuroscience Source Type: research

Phosphodiesterase 10A levels are related to striatal function in schizophrenia: a combined positron emission tomography and functional magnetic resonance imaging study.
Authors: Persson J, Szalisznyó K, Antoni G, Wall A, Fällmar D, Zora H, Bodén R Abstract Pharmacological inhibition of phosphodiesterase 10A (PDE10A) is being investigated as a treatment option in schizophrenia. PDE10A acts postsynaptically on striatal dopamine signaling by regulating neuronal excitability through its inhibition of cyclic adenosine monophosphate (cAMP), and we recently found it to be reduced in schizophrenia compared to controls. Here, this finding of reduced PDE10A in schizophrenia was followed up in the same sample to investigate the effect of reduced striatal PDE10A on the neur...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 25, 2019 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Schizophrenia-spectrum psychopathology in obsessive –compulsive disorder: an empirical study
In conclusion, a high proportion of clinically diagnosed OCD patients fulfilled d iagnostic criteria of a schizophrenia-spectrum disorder. The conspicuous obsessive–compulsive symptomatology may have resulted in a disregard of psychotic symptoms and other psychopathology. Furthermore, the differentiation of obsessions from related psychopathological phenomena is insufficient an d a conceptual and empirical effort in this domain is required in the future. (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - May 25, 2019 Category: Neuroscience Source Type: research

Neurobiological effects of aerobic exercise, with a focus on patients with schizophrenia.
Authors: Maurus I, Hasan A, Röh A, Takahashi S, Rauchmann B, Keeser D, Malchow B, Schmitt A, Falkai P Abstract Schizophrenia is a severe neuropsychiatric disease that is associated with neurobiological alterations in multiple brain regions and peripheral organs. Negative symptoms and cognitive deficits are present in about half of patients and are difficult to treat, leading to an unfavorable functional outcome. To investigate the impact of aerobic exercise on various neurobiological parameters, we conducted a narrative review. Add-on aerobic exercise was shown to be effective in improving negative and general...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 23, 2019 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Neurological soft signs and neurocognitive deficits in remitted patients with schizophrenia, their first-degree unaffected relatives, and healthy controls
This study aimed to explore the NSS and ND and examine the comparative relationship between them in RP, their first-degree unaffected relatives (FDR), and healthy controls, furthermore, to seek potential endophenotypes subitems of NSS and ND and create a composite endophenotype. 86 RP, 86 FDR, and 86 healthy controls were included. NSS and ND were independently assessed with Cambridge Neurological Inventory and MATRICSTM Consensus Cognitive Battery. RP had more NSS and ND than FDR in all subitems except disinhibition, information processing speed, working memory, and visual memory. Similarly, FDR presented poorer performan...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 23, 2019 Category: Neuroscience Source Type: research

Correction to: New trends in  cannabis potency in USA and Europe during the last decade (2008–2017)
In the original publication, table  2 contained data that should not have been included in table 2 and also was not discussed in the body of the manuscript. (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - May 23, 2019 Category: Neuroscience Source Type: research

Facial emotion recognition in people with schizophrenia and a history of violence: a mediation analysis.
In this study, we compared facial emotion recognition performance in age- and gender-matched schizophrenia spectrum disorders subjects with (N = 52) and without (N = 52) a history of violence. Data on current symptom severity, Cluster B personality status, past victimization, and alcohol and substance misuse were also collected. Compared to those without, subjects with a history of violence showed worse facial emotion recognition performances, involving anger, fear, disgust, sadness, and happiness. When formally testing the reporting of angry faces, evidence of enhanced sensitivity to anger was ...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 22, 2019 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Phosphodiesterase 10A levels are related to striatal function in schizophrenia: a combined positron emission tomography and functional magnetic resonance imaging study
AbstractPharmacological inhibition of phosphodiesterase 10A (PDE10A) is being investigated as a treatment option in schizophrenia. PDE10A acts postsynaptically on striatal dopamine signaling by regulating neuronal excitability through its inhibition of cyclic adenosine monophosphate (cAMP), and we recently found it to be reduced in schizophrenia compared to controls. Here, this finding of reduced PDE10A in schizophrenia was followed up in the same sample to investigate the effect of reduced striatal PDE10A on the neural and behavioral function of striatal and downstream basal ganglia regions. A positron emission tomography...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 22, 2019 Category: Neuroscience Source Type: research

Neurobiological effects of aerobic exercise, with a focus on patients with schizophrenia
AbstractSchizophrenia is a severe neuropsychiatric disease that is associated with neurobiological alterations in multiple brain regions and peripheral organs. Negative symptoms and cognitive deficits are present in about half of patients and are difficult to treat, leading to an unfavorable functional outcome. To investigate the impact of aerobic exercise on various neurobiological parameters, we conducted a narrative review. Add-on aerobic exercise was shown to be effective in improving negative and general symptoms, cognition, global functioning, and quality of life in schizophrenia patients. Based on findings in health...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 21, 2019 Category: Neuroscience Source Type: research

Facial emotion recognition in people with schizophrenia and a history of violence: a mediation analysis
In this study, we compared facial emotion recognition performance in age- and gender-matched schizophrenia spectrum disorders subjects with (N = 52) and without (N = 52) a history of violence. Data on current symptom severity, Cluster B personality status, past victimization, and alcohol and substance misuse were also collected. Compared to those without, subjects with a history of violence showed worse facial emotion recognition performances, involving a nger, fear, disgust, sadness, and happiness. When formally testing the reporting of angry faces, evidence of enhanced sensitivity to anger was...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 20, 2019 Category: Neuroscience Source Type: research

A new role for oligodendrocytes and myelination in schizophrenia and affective disorders?
Authors: Schmitt A, Simons M, Cantuti-Castelvetri L, Falkai P PMID: 31076838 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - May 13, 2019 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Attention as neurocognitive endophenotype of ADHD across the life span: a family study.
Authors: Boxhoorn S, Lopez E, Schmidt C, Schulze D, Hänig S, Cholemkery H, Freitag CM Abstract Endophenotypes mediate pathways between genetic variations and the psychiatric phenotype, or share genetic risk with the psychiatric phenotype. Identifying endophenotypes is an important step to unravel disease pathways underlying complex psychiatric phenotypes such as ADHD. Potential viable endophenotypes for ADHD across the lifespan are neurocognitive measures of basic attention functions, such as sustained attention, and executive attention functions (EF), such as inhibition. The present study evaluated the endoph...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 10, 2019 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

A new role for oligodendrocytes and myelination in schizophrenia and affective disorders?
(Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - May 10, 2019 Category: Neuroscience Source Type: research

Predictors of diagnostic stability in acute and transient psychotic disorders: validation of previous findings and implications for ICD-11.
Authors: López-Díaz Á, Fernández-González JL, Lara I, Ruiz-Veguilla M Abstract Acute and transient psychotic disorders (ATPD) have moderate prospective diagnostic stability. Female gender, older age at onset, good premorbid adjustment, abrupt onset, shifting polymorphic symptomatology and absence of schizophrenic features have been found to be predictive factors of diagnostic stability in ATPDs. Nevertheless, most of these findings need to be replicated. The purpose of this study was to evaluate the diagnostic stability of patients with ATPD, and to determine whether previously ac...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 9, 2019 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Maternal verbal aggression in early infancy and child's internalizing symptoms: interaction by common oxytocin polymorphisms.
This study examined whether maternal verbally aggressive behavior in early infancy interacts with oxytocin polymorphisms in developing internalizing symptoms at ages 5-6 and 11-12. In the Amsterdam-Born-Children-and-their-Development (ABCD) study, a large observational, population-based birth cohort, maternal verbally aggressive behavior was assessed in the 13th postnatal week by a self-report questionnaire. Internalizing symptoms at age 5-6 were assessed by maternal report (N = 969) and internalizing symptoms at age 11-12 were assessed by self-report (N = 750). Data on oxytocin receptor polymor...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 9, 2019 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Anhedonia in adolescents at ultra-high risk (UHR) of psychosis: findings from a 1-year longitudinal study.
Authors: Pelizza L, Poletti M, Azzali S, Paterlini F, Garlassi S, Scazza I, Chiri LR, Pupo S, Gebhardt E, Raballo A Abstract Previous findings suggested deficits in pleasure experience in schizophrenia, but little is known in psychosis risk prodrome, especially in adolescence. Aim of this study was (1) to assess anhedonia in distinct help-seeking subgroups of adolescents identified through the ultra-high risk (UHR) criteria, (2) to explore any association of anhedonia with other psychopathological aspects in the UHR group, and (3) to monitor longitudinally the stability of anhedonia in UHR individuals across 1-year...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 8, 2019 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Attention as neurocognitive endophenotype of ADHD across the life span: a family study
AbstractEndophenotypes mediate pathways between genetic variations and the psychiatric phenotype, or share genetic risk with the psychiatric phenotype. Identifying endophenotypes is an important step to unravel disease pathways underlying complex psychiatric phenotypes such as ADHD. Potential viable endophenotypes for ADHD across the lifespan are neurocognitive measures of basic attention functions, such assustained attention, and executive attention functions (EF), such asinhibition. The present study evaluated the endophenotype criteria of familiality and state-independency for measures of basic attention and EF in affec...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 8, 2019 Category: Neuroscience Source Type: research

Maternal verbal aggression in early infancy and child ’s internalizing symptoms: interaction by common oxytocin polymorphisms
This study examined whether maternal verbally aggressive behavior in early infancy interacts with oxytocin polymorphisms in developing internalizing symptoms at ages 5 –6 and 11–12. In the Amsterdam-Born-Children-and-their-Development (ABCD) study, a large observational, population-based birth cohort, maternal verbally aggressive behavior was assessed in the 13th postnatal week by a self-report questionnaire. Internalizing symptoms at age 5–6 were assessed b y maternal report (N = 969) and internalizing symptoms at age 11–12 were assessed by self-report (N = 750). Data on...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 7, 2019 Category: Neuroscience Source Type: research

Predictors of diagnostic stability in acute and transient psychotic disorders: validation of previous findings and implications for ICD-11
AbstractAcute and transient psychotic disorders (ATPD) have moderate prospective diagnostic stability. Female gender, older age at onset, good premorbid adjustment, abrupt onset, shifting polymorphic symptomatology and absence of schizophrenic features have been found to be predictive factors of diagnostic stability in ATPDs. Nevertheless, most of these findings need to be replicated. The purpose of this study was to evaluate the diagnostic stability of patients with ATPD, and to determine whether previously accepted predictors of diagnostic stability for ATPD could be externally validated in our cohort. To that end, a pro...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 6, 2019 Category: Neuroscience Source Type: research

Anhedonia in adolescents at ultra-high risk (UHR) of psychosis: findings from a 1-year longitudinal study
AbstractPrevious findings suggested deficits in pleasure experience in schizophrenia, but little is known in psychosis risk prodrome, especially in adolescence. Aim of this study was (1) to assess anhedonia in distinct help-seeking subgroups of adolescents identified through the ultra-high risk (UHR) criteria, (2) to explore any association of anhedonia with other psychopathological aspects in the UHR group, and (3) to monitor longitudinally the stability of anhedonia in UHR individuals across 1-year follow-up period. 123 participants (13 –18 years) completed the Comprehensive Assessment of At-Risk Mental States...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 4, 2019 Category: Neuroscience Source Type: research

Improvement in verbal learning over the first year of antipsychotic treatment is associated with serum HDL levels in a cohort of first episode psychosis patients.
Authors: Gjerde PB, Simonsen CE, Lagerberg TV, Steen NE, Ueland T, Andreassen OA, Steen VM, Melle I Abstract To investigate whether changes in serum lipids are associated with cognitive performance in first episode psychosis (FEP) patients during their first year of antipsychotic drug treatment. One hundred and thirty-two antipsychotic-treated FEP patients were included through the TOP study along with 83 age- and gender-matched healthy controls (HC). Information regarding cognitive performance, psychotic symptoms, lifestyle, body mass index, serum lipids [total cholesterol, high-density lipoprotein (HDL) cholester...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 29, 2019 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

A follow-up study of metabolic syndrome in schizophrenia.
In conclusion, the MetS prevalence was found to be increased among schizophrenia patients over time, and the increase in the young age group was particularly striking. Among all of the factors investigated, nutritional status was found to play a major role in this increased prevalence. PMID: 31030256 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - April 29, 2019 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Prevalence of affective disorders and dementia in inflammatory polyarthropathies.
The objective of this study was to compare the frequency of comorbid dementia, affective disorders, and inflammatory polyarthropathies. Healthcare data obtained via the German Hospital Fees Act from two independent databases with more than 7.4 million cases were analyzed to compare the prevalence of comorbid disorders. Comorbid inflammatory polyarthropathy was observed in 2.27% of patients diagnosed with affective disorders and 1.35% of patients with dementia (p 
Source: European Archives of Psychiatry and Clinical Neuroscience - April 28, 2019 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

A follow-up study of metabolic syndrome in schizophrenia
In conclusion, the MetS prevalence was found to be increased among schizophrenia patients over time, and the increase in the young age group was particularly striking. Among all of t he factors investigated, nutritional status was found to play a major role in this increased prevalence. (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - April 27, 2019 Category: Neuroscience Source Type: research

Improvement in verbal learning over the first year of antipsychotic treatment is associated with serum HDL levels in a cohort of first episode psychosis patients
AbstractTo investigate whether changes in serum lipids are associated with cognitive performance in first episode psychosis (FEP) patients during their first year of antipsychotic drug treatment. One hundred and thirty-two antipsychotic-treated FEP patients were included through the TOP study along with 83 age- and gender-matched healthy controls (HC). Information regarding cognitive performance, psychotic symptoms, lifestyle, body mass index, serum lipids [total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein cholesterol, and triglycerides] and antipsychotic treatment was obtained at basel...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 27, 2019 Category: Neuroscience Source Type: research

Using World Health Organization Disability Assessment Schedule 2.0 in people with schizophrenia: a 4-year follow-up.
Authors: Chen R, Liou TH, Miao NF, Chang KH, Yen CF, Liao HF, Chi WC, Chou KR Abstract Little is known about the changes of people with schizophrenia disability in Taiwan who receive routine treatments under the current mental healthcare system. The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) was used to assess and track changes in the degree of disability in people with schizophrenia before and after 4 years of follow-up. Data on 4497 people with schizophrenia were acquired from the Taiwan Data Bank of Persons with Disability. The WHODAS 2.0 was used for disability assessment, and the...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 25, 2019 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Prevalence of affective disorders and dementia in inflammatory polyarthropathies
The objective of this study was to compare the frequency of comorbid dementia, affective disorders, and inflammatory polyarthropathies. Healthcare data obtained via the German Hospital Fees Act from two independent databases with more than 7.4 million cases were analyzed to compare the prevalence of comorbid disorders. Comorbid inflammatory polyarthropathy was observed in 2.27% of patients diagnosed with affective disorders and 1.35% of patients with dementia (p 
Source: European Archives of Psychiatry and Clinical Neuroscience - April 25, 2019 Category: Neuroscience Source Type: research

Using World Health Organization Disability Assessment Schedule 2.0 in people with schizophrenia: a 4-year follow-up
AbstractLittle is known about the changes of people with schizophrenia disability in Taiwan who receive routine treatments under the current mental healthcare system. The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) was used to assess and track changes in the degree of disability in people with schizophrenia before and after 4 years of follow-up. Data on 4497 people with schizophrenia were acquired from the Taiwan Data Bank of Persons with Disability. The WHODAS 2.0 was used for disability assessment, and the chi-square test, logistic regression and generalised estimating equations were adopted...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 22, 2019 Category: Neuroscience Source Type: research

Relationship between motor function and psychotic symptomatology in young-adult patients with schizophrenia.
Authors: Wang SM, Ouyang WC, Wu MY, Kuo LC Abstract Motor abnormalities have been indicated to be a core manifestation of schizophrenia and not just motor side-effects of antipsychotics. However, little is known about whether all of the complete motor function, including fine motor function, muscle strength, and balance is linked to psychotic symptoms. Therefore, this study was to investigate association between complete motor function and psychotic symptoms in young-adult schizophrenia patients who had no extrapyramidal motor symptoms, which were assessed using the Extrapyramidal Symptom Rating Scale. Seventy schi...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 13, 2019 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

STX1A gene variations contribute to the susceptibility of children attention-deficit/hyperactivity disorder: a case-control association study.
Authors: Wang M, Gu X, Huang X, Zhang Q, Chen X, Wu J Abstract It was presumed syntaxin-1A (STX1A) might relate to the pathophysiology of attention-deficit/hyperactivity disorder (ADHD), but the results were inconsistent. The present study aims to confirm whether the STX1A gene is involved in the susceptibility of children ADHD. We genotyped three single nucleotide polymorphisms (SNPs) of STX1A gene using Sequenom MassARRAY technology. A case-control study was performed among Chinese Han population including 754 cases and 772 controls from two different provinces. The Conners Parent Symptom Questionnaire and Integr...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 13, 2019 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Towards an improved access to psychiatric rehabilitation: availability and effectiveness at 1-year follow-up of psychoeducation, cognitive remediation therapy, cognitive behaviour therapy and social skills training in the FondaMental Advanced Centers of Expertise-Schizophrenia (FACE-SZ) national cohort.
The objectives of the present study were (i) to assess the proportion of SZ outpatients who benefited from PIs between 2010 and 2015 in France after an Expert Center Intervention in a national multicentric non-selected community-dwelling sample; (ii) to assess PIs' effectiveness at 1-year follow-up. 183 SZ outpatients were recruited from FondaMental Advanced Centers of Expertise for Schizophrenia cohort. Baseline and 1-year evaluations included sociodemographic data, current treatments, illness characteristics and standardized scales for clinical severity, adherence to treatment, quality of life, a large cognitive battery,...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 11, 2019 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

STX1A gene variations contribute to the susceptibility of children attention-deficit/hyperactivity disorder: a case –control association study
AbstractIt was presumed syntaxin-1A (STX1A) might relate to the pathophysiology of attention-deficit/hyperactivity disorder (ADHD), but the results were inconsistent. The present study aims to confirm whether theSTX1A gene is involved in the susceptibility of children ADHD. We genotyped three single nucleotide polymorphisms (SNPs) ofSTX1A gene using Sequenom MassARRAY technology. A case –control study was performed among Chinese Han population including 754 cases and 772 controls from two different provinces. The Conners Parent Symptom Questionnaire and Integrated Visual and Auditory Continuous Performance Test were ...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 11, 2019 Category: Neuroscience Source Type: research

Relationship between motor function and psychotic symptomatology in young –adult patients with schizophrenia
AbstractMotor abnormalities have been indicated to be a core manifestation of schizophrenia and not just motor side-effects of antipsychotics. However, little is known about whether all of the complete motor function, including fine motor function, muscle strength, and balance is linked to psychotic symptoms. Therefore, this study was to investigate association between complete motor function and psychotic symptoms in young –adult schizophrenia patients who had no extrapyramidal motor symptoms, which were assessed using the Extrapyramidal Symptom Rating Scale. Seventy schizophrenia patients were recruited. Fine motor...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 11, 2019 Category: Neuroscience Source Type: research

Cortico-thalamic dysconnection in early-stage schizophrenia: a functional connectivity magnetic resonance imaging study.
Authors: Chen MH, Chang WC, Bai YM, Huang KL, Tu PC, Su TP, Li CT, Lin WC, Tsai SJ, Hsu JW Abstract Studies have indicated thalamus-related network dysfunction in schizophrenia and psychotic disorders. However, whether thalamus-related functional connectivity (FC) contributes to the psychopathology and cognitive deficits of early-stage schizophrenia requires further investigation. A total of 34 patients with early-stage schizophrenia (illness duration = 1.62 ± 1.16 years; age = 26.00 ± 6.34 years) and 34 age- and sex-matched healthy controls...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 8, 2019 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research