Mental health effects of infection containment strategies: quarantine and isolation-a systematic review and meta-analysis.
Authors: Henssler J, Stock F, van Bohemen J, Walter H, Heinz A, Brandt L Abstract Due to the ongoing COVID-19 pandemic, an unprecedented number of people worldwide is currently affected by quarantine or isolation. These measures have been suggested to negatively impact on mental health. We conducted the first systematic literature review and meta-analysis assessing the psychological effects in both quarantined and isolated persons compared to non-quarantined and non-isolated persons. PubMed, PsycINFO, and Embase databases were searched for studies until April 22, 2020 (Prospero Registration-No.: CRD42020180043). We...
Source: European Archives of Psychiatry and Clinical Neuroscience - October 9, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Mental health effects of infection containment strategies: quarantine and isolation —a systematic review and meta-analysis
AbstractDue to the ongoing COVID-19 pandemic, an unprecedented number of people worldwide is currently affected by quarantine or isolation. These measures have been suggested to negatively impact on mental health. We conducted the first systematic literature review and meta-analysis assessing the psychological effects in both quarantined and isolated persons compared to non-quarantined and non-isolated persons. PubMed, PsycINFO, and Embase databases were searched for studies until April 22, 2020 (Prospero Registration-No.: CRD42020180043). We followed PRISMA and MOOSE guidelines for data extraction and synthesis and the Ne...
Source: European Archives of Psychiatry and Clinical Neuroscience - October 5, 2020 Category: Neuroscience Source Type: research

Reduced habenular volumes and neuron numbers in male heroin addicts: a post-mortem study.
Authors: Müller UJ, Ahrens M, Vasilevska V, Dobrowolny H, Schiltz K, Schlaaff K, Mawrin C, Frodl T, Bogerts B, Gos T, Truebner K, Bernstein HG, Steiner J Abstract The Habenula is increasingly being investigated in addiction. Reduced volumes of other relevant brain regions in addiction, such as nucleus accumbens, globus pallidus and hypothalamus have been reported. Reduced volumes of the habenula as well as reduced neuronal cell count in the habenula have also been reported in mood disorders and an overlap between mood disorders and addiction is clinically widely recognized. Thus, our aim was to investigate pos...
Source: European Archives of Psychiatry and Clinical Neuroscience - October 3, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Reduced habenular volumes and neuron numbers in male heroin addicts: a post-mortem study
AbstractThe Habenula is increasingly being investigated in addiction. Reduced volumes of other relevant brain regions in addiction, such as nucleus accumbens, globus pallidus and hypothalamus have been reported. Reduced volumes of the habenula as well as reduced neuronal cell count in the habenula have also been reported in mood disorders and an overlap between mood disorders and addiction is clinically widely recognized. Thus, our aim was to investigate possible volume and neuronal cell count differences in heroin addicts compared to healthy controls. Volumes of the medial (MHB) and lateral habenula (LHB) in heroin addict...
Source: European Archives of Psychiatry and Clinical Neuroscience - September 30, 2020 Category: Neuroscience Source Type: research

The role of neurotropism in psychiatric patients with COVID-19.
Authors: Diaz AD, Baweja R PMID: 32980914 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - September 29, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Association between cannabinoid 1 receptor availability and glutamate levels in healthy controls and drug-free patients with first episode psychosis: a multi-modal PET and 1H-MRS study.
Authors: Borgan F, Veronese M, Reis Marques T, Lythgoe DJ, Howes O Abstract Cannabinoid 1 receptor and glutamatergic dysfunction have both been implicated in the pathophysiology of schizophrenia. However, it remains unclear if cannabinoid 1 receptor alterations shown in drug-naïve/free patients with first episode psychosis may be linked to glutamatergic alterations in the illness. We aimed to investigate glutamate levels and cannabinoid 1 receptor levels in the same region in patients with first episode psychosis. Forty volunteers (20 healthy volunteers, 20 drug-naïve/free patients with first episode psyc...
Source: European Archives of Psychiatry and Clinical Neuroscience - September 29, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Association between cannabinoid 1 receptor availability and glutamate levels in healthy controls and drug-free patients with first episode psychosis: a multi-modal PET and 1H-MRS study
AbstractCannabinoid 1 receptor and glutamatergic dysfunction have both been implicated in the pathophysiology of schizophrenia. However, it remains unclear if cannabinoid 1 receptor alterations shown in drug-na ïve/free patients with first episode psychosis may be linked to glutamatergic alterations in the illness. We aimed to investigate glutamate levels and cannabinoid 1 receptor levels in the same region in patients with first episode psychosis. Forty volunteers (20 healthy volunteers, 20 drug-naïve/f ree patients with first episode psychosis diagnosed with schizophrenia/schizoaffective disorder) were included...
Source: European Archives of Psychiatry and Clinical Neuroscience - September 27, 2020 Category: Neuroscience Source Type: research

The role of neurotropism in psychiatric patients with COVID-19
(Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - September 26, 2020 Category: Neuroscience Source Type: research

Reply to the likeliness of 0.5 and 1.0  ms stimuli in bilateral electroconvulsive therapy (ECT).
Reply to the likeliness of 0.5 and 1.0 ms stimuli in bilateral electroconvulsive therapy (ECT). Eur Arch Psychiatry Clin Neurosci. 2020 Sep 24;: Authors: de Arriba-Arnau A, Soria V, Urretavizcaya M PMID: 32974729 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - September 26, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Reply to the likeliness of 0.5 and 1.0  ms stimuli in bilateral electroconvulsive therapy (ECT)
(Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - September 23, 2020 Category: Neuroscience Source Type: research

Effects of rhythmic auditory stimulation on upper-limb movement speed in patients with schizophrenia spectrum disorders.
This study was to examine immediate effects of rhythmic auditory stimulation (RAS) on upper-limb movement speed in patients. Thirty patients and 30 psychiatrically healthy people executed the right-hand task and the both-hand task of the Purdue Pegboard Test when listening to RAS with two tempi: normal (equal to the fastest movement tempo for each participant without RAS) and fast (120% of the normal tempo). The testing order of the RAS tempi for each participant was randomized. Patients had lower scores of right-hand and both-hand tasks than did psychiatrically healthy people. Scores of right-hand and both-hand tasks were...
Source: European Archives of Psychiatry and Clinical Neuroscience - September 19, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Effects of rhythmic auditory stimulation on upper-limb movement speed in patients with schizophrenia spectrum disorders
This study was to examine immediate effects of rhythmic auditory stimulation (RAS) on upper-limb movement speed in patients. Thirty patients and 30 psychiatrically healthy people executed the right-hand task and the both-hand task of the Purdue Pegboard Test when listening to RAS with two tempi: normal (equal to the fastest movement tempo for each participant without RAS) and fast (120% of the normal tempo). The testing order of the RAS tempi for each participant was randomized. Patients had lower scores of right-hand and both-hand tasks than did psychiatrically healthy people. Scores of right-hand and both-hand tasks were...
Source: European Archives of Psychiatry and Clinical Neuroscience - September 16, 2020 Category: Neuroscience Source Type: research

The relationship between cortisol reactivity and emotional brain function is differently moderated by childhood trauma, in bipolar disorder, schizophrenia and healthy individuals.
Authors: Quidé Y, Girshkin L, Watkeys OJ, Carr VJ, Green MJ Abstract Childhood trauma is a risk factor for psychotic and mood disorders that is associated with abnormal hypothalamic-pituitary-adrenal (HPA) axis function in response to stress and abnormal social brain function. Here, we aimed to determine whether childhood trauma exposure would differently moderate associations between cortisol reactivity and social brain function, among cases with schizophrenia (SZ), bipolar disorder (BD) and in healthy individuals (HC). Forty cases with SZ, 35 with BD and 34 HCs underwent functional magnetic resonance imagi...
Source: European Archives of Psychiatry and Clinical Neuroscience - September 16, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

The relationship between cortisol reactivity and emotional brain function is differently moderated by childhood trauma, in bipolar disorder, schizophrenia and healthy individuals
AbstractChildhood trauma is a risk factor for psychotic and mood disorders that is associated with abnormal hypothalamic –pituitary–adrenal (HPA) axis function in response to stress and abnormal social brain function. Here, we aimed to determine whether childhood trauma exposure would differently moderate associations between cortisol reactivity and social brain function, among cases with schizophrenia (SZ), bipol ar disorder (BD) and in healthy individuals (HC). Forty cases with SZ, 35 with BD and 34 HCs underwent functional magnetic resonance imaging while performing an emotional face-matching task. Participa...
Source: European Archives of Psychiatry and Clinical Neuroscience - September 13, 2020 Category: Neuroscience Source Type: research

The likeliness of 0.5 and 1.0  ms stimuli in BL ECT.
The likeliness of 0.5 and 1.0 ms stimuli in BL ECT. Eur Arch Psychiatry Clin Neurosci. 2020 Sep 10;: Authors: Spaans HP PMID: 32910295 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - September 12, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Double bookkeeping and schizophrenia spectrum: divided unified phenomenal consciousness.
Authors: Parnas J, Urfer-Parnas A, Stephensen H Abstract Eugen Bleuler, the founder of the concept of schizophrenia, pointed out that psychotic patients were able to live in two disjoint worlds (namely, the social, intersubjective world and the delusional world). He termed this phenomenon "double bookkeeping," but did not provide any conceptual elaboration of this phenomenon or its possible mechanisms. Double bookkeeping has been neglected in mainstream psychiatry, but it has been addressed in recent theoretical work, however mainly concerned with the issue of delusion. In this article, we present clinica...
Source: European Archives of Psychiatry and Clinical Neuroscience - September 10, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

The likeliness of 0.5 and 1.0  ms stimuli in BL ECT
(Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - September 9, 2020 Category: Neuroscience Source Type: research

Missed diagnoses and misdiagnoses of adults with autism spectrum disorder.
Authors: Fusar-Poli L, Brondino N, Politi P, Aguglia E Abstract Autism spectrum disorder (ASD) is a group of life-long neurodevelopmental disorders affecting 1.5% of the general population. The present study aimed to evaluate the psychiatric history of a group of adults who received the first diagnosis of ASD in two Italian university centers. Diagnoses of ASD were confirmed by a team of psychiatrists with wide expertise in the field, after the administration of standardized tools (i.e., ADOS-2, ADI-R). The sample comprised 161 participants, of which 114 (79.5%) were males. The median age of diagnosis was 23 y...
Source: European Archives of Psychiatry and Clinical Neuroscience - September 9, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Cognitive, community functioning and clinical correlates of the Clinical Assessment Interview for Negative Symptoms (CAINS) in psychotic disorders.
This study was aimed at extending the analysis of the clinical, functional and cognitive correlates of CAINS dimensions in a sample of patients with psychotic disorders (n = 98) and 50 healthy controls.A psychopathological evaluation was conducted by using the Comprehensive Assessment of Symptoms and History (CASH). To assess the extrapyramidal signs, the UKU scale was used. Community functioning was evaluated by means of real-world and functional attainment measures. Additionally, a full neuropsychological test battery was administered. Pearson correlation and hierarchical multiple linear regression analyses...
Source: European Archives of Psychiatry and Clinical Neuroscience - September 9, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Double bookkeeping and schizophrenia spectrum: divided unified phenomenal consciousness
AbstractEugen Bleuler, the founder of the concept of schizophrenia, pointed out that psychotic patients were able to live in two disjoint worlds (namely, the social, intersubjective world and the delusional world). He termed this phenomenon “double bookkeeping,” but did not provide any conceptual elaboration of this phenomenon or its possible mechanisms. Double bookkeeping has been neglected in mainstream psychiatry, but it has been addressed in recent theoretical work, however mainly concerned with the issue of delusion. In this a rticle, we present clinical material that supports the view that double bookkeep...
Source: European Archives of Psychiatry and Clinical Neuroscience - September 7, 2020 Category: Neuroscience Source Type: research

Cognitive, community functioning and clinical correlates of the Clinical Assessment Interview for Negative Symptoms (CAINS) in psychotic disorders
This study was aimed at extending the analysis of the clinical, functional and cognitive correlates of CAINS dimensions in a sample of patients with psychotic disorders (n = 98) and 50 healthy controls.A psychopathological evaluation was conducted by using the Comprehensive Assessment of Symptoms and History (CASH). To assess the extrapyramidal signs, the UKU scale was used. Community functioning was evaluated by means of real-world and functional attainment measures. Additionally, a full neuropsychological test battery was administered. Pearson correlation and hierarchical multiple linear regression analyses...
Source: European Archives of Psychiatry and Clinical Neuroscience - September 6, 2020 Category: Neuroscience Source Type: research

Missed diagnoses and misdiagnoses of adults with autism spectrum disorder
AbstractAutism spectrum disorder (ASD) is a group of life-long neurodevelopmental disorders affecting 1.5% of the general population. The present study aimed to evaluate the psychiatric history of a group of adults who received the first diagnosis of ASD in two Italian university centers. Diagnoses of ASD were confirmed by a team of psychiatrists with wide expertise in the field, after the administration of standardized tools (i.e., ADOS-2, ADI-R). The sample comprised 161 participants, of which 114 (79.5%) were males. The median age of diagnosis was 23  years (range 18–55), with a median IQ of 100 (range 30&nda...
Source: European Archives of Psychiatry and Clinical Neuroscience - September 5, 2020 Category: Neuroscience Source Type: research

Prefrontal resting-state connectivity and antidepressant response: no associations in the ELECT-TDCS trial.
This study did not reveal an association between antidepressants effects of tDCS and baseline rsFC, unlike the gray matter volume findings. Thus, the antidepressant effects of tDCS may be differentially related to structural and functional MRI measurements. PMID: 32880057 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - September 5, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Palliative and high-intensity end-of-life care in schizophrenia patients with lung cancer: results from a French national population-based study.
The objective was to compare end-of-life care delivered to patients with schizophrenia and lung cancer with patients without severe mental disorder. This population-based cohort study included all patients aged 15 and older who died from their terminal lung cancer in hospital in France (2014-2016). Schizophrenia patients and controls without severe mental disorder were selected and indicators of palliative care and high-intensity end-of-life care were compared. Multivariable generalized log-linear models were performed, adjusted for sex, age, year of death, social deprivation, time between cancer diagnosis and death, metas...
Source: European Archives of Psychiatry and Clinical Neuroscience - September 3, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Understanding the mechanisms of treatment response in depression, focus on electro-convulsive therapy.
Authors: Binder EB PMID: 32865635 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - September 2, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Prefrontal resting-state connectivity and antidepressant response: no associations in the ELECT-TDCS trial
This study did not reveal an association between antidepressants effects of tDCS and baseline rsFC, unlike the gray matter volume findings. Thus, the antidepressant effects of tDCS may be differentially related to structural and functional MRI measurements. (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - September 1, 2020 Category: Neuroscience Source Type: research

Palliative and high-intensity end-of-life care in schizophrenia patients with lung cancer: results from a French national population-based study
The objective was to compare end-of-life care delivered to patients with schizophrenia and lung cancer with patients without severe mental disorder. This population-based cohort study included all patients aged 15 and older who died from their terminal lung cancer in hospital in France (2014 –2016). Schizophrenia patients and controls without severe mental disorder were selected and indicators of palliative care and high-intensity end-of-life care were compared. Multivariable generalized log-linear models were performed, adjusted for sex, age, year of death, social deprivation, time b etween cancer diagnosis and deat...
Source: European Archives of Psychiatry and Clinical Neuroscience - September 1, 2020 Category: Neuroscience Source Type: research

Understanding the mechanisms of treatment response in depression, focus on electro-convulsive therapy
(Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - August 30, 2020 Category: Neuroscience Source Type: research

Subjective burden and perspectives of German healthcare workers during the COVID-19 pandemic.
Authors: Kramer V, Papazova I, Thoma A, Kunz M, Falkai P, Schneider-Axmann T, Hierundar A, Wagner E, Hasan A Abstract Healthcare workers (HCW) face tremendous challenges during the COVID-19 pandemic. Little is known about the subjective burden, views, and COVID-19 infection status of HCWs. The aim of this work was to evaluate the subjective burden, the perception of the information policies, and the agreement on structural measures in a large cohort of German HCW during the COVID-19 pandemic. This country-wide anonymous online survey was carried out from April 15th until May 1st, 2020. 25 content-related quest...
Source: European Archives of Psychiatry and Clinical Neuroscience - August 21, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

The neural correlates of the visual consciousness in schizophrenia: an fMRI study.
Authors: Lefebvre S, Very E, Jardri R, Horn M, Yrondi A, Delmaire C, Rascle C, Dujardin K, Thomas P, Pins D Abstract In the current literature, two distinct and opposite models are suggested to explain the consciousness disorders in schizophrenia. The first one suggests that consciousness disorders rely on a low-level processing deficit, when the second model suggests that consciousness disorders rely on disruption in the ability to consciously access information, with preserved unconscious processing. The current study aims to understand the mechanisms associated with visual consciousness disorder in order to pave...
Source: European Archives of Psychiatry and Clinical Neuroscience - August 20, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

The neural correlates of the visual consciousness in schizophrenia: an fMRI study
AbstractIn the current literature, two distinct and opposite models are suggested to explain the consciousness disorders in schizophrenia. The first one suggests that consciousness disorders rely on a low-level processing deficit, when the second model suggests that consciousness disorders rely on disruption in the ability to consciously access information, with preserved unconscious processing. The current study aims to understand the mechanisms associated with visual consciousness disorder in order to pave the road that will settle the debate regarding these hypotheses. During a functional magnetic resonance imaging sess...
Source: European Archives of Psychiatry and Clinical Neuroscience - August 18, 2020 Category: Neuroscience Source Type: research

Subjective burden and perspectives of German healthcare workers during the COVID-19 pandemic
AbstractHealthcare workers (HCW) face tremendous challenges during the COVID-19 pandemic. Little is known about the subjective burden, views, and COVID-19 infection status of HCWs. The aim of this work was to  evaluate the subjective burden, the perception of the information policies, and the agreement on structural measures in a large cohort of German HCW during the COVID-19 pandemic. This country-wide anonymous online survey was carried out from April 15th until May 1st, 2020. 25 content-related quest ions regarding the subjective burden and other dimensions were evaluated. We evaluated different dimensions of subje...
Source: European Archives of Psychiatry and Clinical Neuroscience - August 18, 2020 Category: Neuroscience Source Type: research

Rapastinel alleviates the neurotoxic effect induced by NMDA receptor blockade in the early postnatal mouse brain.
Authors: Vasilescu AN, Mallien A, Pfeiffer N, Lang UE, Gass P, Inta D Abstract Rapastinel is a novel psychoactive substance that acts as an N-methyl-D-aspartate-receptor (NMDAR) agonist and triggers antidepressant- and antipsychotic-like effects in animal models. However, it is unknown if rapastinel possesses a better side-effect profile than fast-acting glutamatergic antidepressants, like ketamine, which trigger neurotoxicity in the perinatal rodent cortex and protracted schizophrenia-like alterations. Here we found a remarkable neuroprotective effect of rapastinel against apoptosis induced by the NMDAR antagonist...
Source: European Archives of Psychiatry and Clinical Neuroscience - August 14, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Aerobic endurance training to improve cognition and enhance recovery in schizophrenia: design and methodology of a multicenter randomized controlled trial.
Authors: Maurus I, Hasan A, Schmitt A, Roeh A, Keeser D, Malchow B, Schneider-Axmann T, Hellmich M, Schmied S, Lembeck M, Keller-Varady K, Papazova I, Hirjak D, Topor CE, Walter H, Mohnke S, Vogel BO, Wölwer W, Schneider F, Henkel K, Meyer-Lindenberg A, Falkai P Abstract Even today, patients with schizophrenia often have an unfavorable outcome. Negative symptoms and cognitive deficits are common features in many patients and prevent recovery. In recent years, aerobic endurance training has emerged as a therapeutic approach with positive effects on several domains of patients' health. However, appropriately siz...
Source: European Archives of Psychiatry and Clinical Neuroscience - August 13, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Immune cell puzzle COVID-19: how do SARS-CoV infections contribute to psychiatric diseases?
Authors: Jung M, Rujescu D PMID: 32749531 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - August 13, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Psychiatric emergency services and non-acute psychiatric services utilization during COVID-19 pandemic.
Authors: Kolar D PMID: 32770363 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - August 13, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Meta-analysis of cognitive functioning in patients with psychotic disorders and obsessive-compulsive symptoms.
Authors: Dijkstra L, Vermeulen J, de Haan L, Schirmbeck F Abstract Obsessive-compulsive symptoms (OCS) in psychotic disorders are associated with unfavorable outcomes, whether this extends to cognitive function remains unclear. We conducted meta-analyses on several cognitive domains to investigate overall group differences between patients with a psychotic disorder and co-occurring OCS (OCS +) and those without OCS (OCS-). We used meta-regression to assess possible confounding effects. No overall associations between OCS + and OCS- in any of the 17 investigated cognitive domains were found. We ...
Source: European Archives of Psychiatry and Clinical Neuroscience - August 13, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

ADHD symptom profiles, intermittent explosive disorder, adverse childhood experiences, and internalizing/externalizing problems in young offenders.
Authors: Barra S, Turner D, Müller M, Hertz PG, Retz-Junginger P, Tüscher O, Huss M, Retz W Abstract Attention-deficit/hyperactivity disorder (ADHD) and co-existing psychiatric/psychological impairments as well as adverse childhood experiences (ACEs) are common among young offenders. Research on their associations is of major importance for early intervention and crime prevention. Intermittent explosive disorder (IED) warrants specific consideration in this regard. To gain sophisticated insights into the occurrence and associations of ADHD, IED, ACEs, and further psychiatric/psychological impairments in y...
Source: European Archives of Psychiatry and Clinical Neuroscience - August 13, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Rapastinel alleviates the neurotoxic effect induced by NMDA receptor blockade in the early postnatal mouse brain
AbstractRapastinel is a novel psychoactive substance that acts as an N-methyl-D-aspartate-receptor (NMDAR) agonist and triggers antidepressant- and antipsychotic-like effects in animal models. However, it is unknown if rapastinel possesses a better side-effect profile than fast-acting glutamatergic antidepressants, like ketamine, which trigger neurotoxicity in the perinatal rodent cortex and protracted schizophrenia-like alterations. Here we found a remarkable neuroprotective effect of rapastinel against apoptosis induced by the NMDAR antagonist MK-801 in comparison to that elicited by clozapine and the mGlu2/3 agonist LY3...
Source: European Archives of Psychiatry and Clinical Neuroscience - August 12, 2020 Category: Neuroscience Source Type: research

ADHD symptom profiles, intermittent explosive disorder, adverse childhood experiences, and internalizing/externalizing problems in young offenders
AbstractAttention-deficit/hyperactivity disorder (ADHD) and co-existing psychiatric/psychological impairments as well as adverse childhood experiences (ACEs) are common among young offenders. Research on their associations is of major importance for early intervention and crime prevention. Intermittent explosive disorder (IED) warrants specific consideration in this regard. To gain sophisticated insights into the occurrence and associations of ADHD, IED, ACEs, and further psychiatric/psychological impairments in young (male and female) offenders, we used latent profile analysis (LPA) to empirically derive subtypes among 15...
Source: European Archives of Psychiatry and Clinical Neuroscience - August 10, 2020 Category: Neuroscience Source Type: research

Meta-analysis of cognitive functioning in patients with psychotic disorders and obsessive –compulsive symptoms
AbstractObsessive –compulsive symptoms (OCS) in psychotic disorders are associated with unfavorable outcomes, whether this extends to cognitive function remains unclear. We conducted meta-analyses on several cognitive domains to investigate overall group differences between patients with a psychotic disorder and co -occurring OCS (OCS +) and those without OCS (OCS−). We used meta-regression to assess possible confounding effects. No overall associations between OCS + and OCS− in any of the 17 investigated cognitive domains were found. We predominantly found large heterogeneity in effe...
Source: European Archives of Psychiatry and Clinical Neuroscience - August 10, 2020 Category: Neuroscience Source Type: research

Effects of bifrontal transcranial direct current stimulation on brain glutamate levels and resting state connectivity: multimodal MRI data for the cathodal stimulation site.
Authors: Mezger E, Rauchmann BS, Brunoni AR, Bulubas L, Thielscher A, Werle J, Mortazavi M, Karali T, Stöcklein S, Ertl-Wagner B, Goerigk S, Padberg F, Keeser D Abstract Transcranial direct current stimulation (tDCS) over prefrontal cortex (PFC) regions is currently proposed as therapeutic intervention for major depression and other psychiatric disorders. The in-depth mechanistic understanding of this bipolar and non-focal stimulation technique is still incomplete. In a pilot study, we investigated the effects of bifrontal stimulation on brain metabolite levels and resting state connectivity under the cathode ...
Source: European Archives of Psychiatry and Clinical Neuroscience - August 4, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Immune cell puzzle COVID-19: how do SARS-CoV infections contribute to psychiatric diseases?
(Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - August 3, 2020 Category: Neuroscience Source Type: research

Aerobic endurance training to improve cognition and enhance recovery in schizophrenia: design and methodology of a multicenter randomized controlled trial
AbstractEven today, patients with schizophrenia often have an unfavorable outcome. Negative symptoms and cognitive deficits are common features in many patients and prevent recovery. In recent years, aerobic endurance training has emerged as a therapeutic approach with positive effects on several domains of patients ’ health. However, appropriately sized, multicenter randomized controlled trials that would allow better generalization of results are lacking. The exercise study presented here is a multicenter, rater-blind, two-armed, parallel-group randomized clinical trial in patients with clinically stable sc hizophr...
Source: European Archives of Psychiatry and Clinical Neuroscience - August 2, 2020 Category: Neuroscience Source Type: research

Effects of bifrontal transcranial direct current stimulation on brain glutamate levels and resting state connectivity: multimodal MRI data for the cathodal stimulation site
AbstractTranscranial direct current stimulation (tDCS) over prefrontal cortex (PFC) regions is currently proposed as therapeutic intervention for major depression and other psychiatric disorders. The in-depth mechanistic understanding of this bipolar and non-focal stimulation technique is still incomplete. In a pilot study, we investigated the effects of bifrontal stimulation on brain metabolite levels and resting state connectivity under the cathode using multiparametric MRI techniques and computational tDCS modeling. Within a double-blind cross-over design, 20 subjects (12 women, 23.7  ± 2 years...
Source: European Archives of Psychiatry and Clinical Neuroscience - August 1, 2020 Category: Neuroscience Source Type: research

Opportunities, risks and challenges in global mental health and population neuroscience: a case of Sino-German cooperation.
Authors: Liu S, Müller S, Dolan RJ, Zhao X, Zheng JC, Heinz A Abstract Large scale prospective cohorts have now been established across several countries, and continents, and among the aims include an assessment of the developmental trajectory of mental disorders. This level of international cooperation helps transfer research findings to new social contexts as well as enabling an assessment of which findings can be replicated, and which interventions are most effective, in different social and cultural settings. However, data sharing across different regional and national health care systems requires a carefu...
Source: European Archives of Psychiatry and Clinical Neuroscience - July 31, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Targeted long-term mental health services in Wuhan dealing with COVID-19.
Authors: Kang L, Wang G, Liu Z PMID: 32719968 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - July 30, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Changes in functional connectivity after theta-burst transcranial magnetic stimulation for post-traumatic stress disorder: a machine-learning study.
Authors: Zandvakili A, Swearingen HR, Philip NS Abstract Intermittent theta burst stimulation (iTBS) is a novel treatment approach for post-traumatic stress disorder (PTSD), and recent neuroimaging work indicates that functional connectivity profiles may be able to identify those most likely to respond. However, prior work has relied on functional magnetic resonance imaging, which is expensive and difficult to scale. Alternatively, electroencephalography (EEG) represents a different approach that may be easier to implement in clinical practice. To this end, we acquired an 8-channel resting-state EEG signal on parti...
Source: European Archives of Psychiatry and Clinical Neuroscience - July 30, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Opportunities, risks and challenges in global mental health and population neuroscience: a case of Sino-German cooperation
AbstractLarge scale prospective cohorts have now been established across several countries, and continents, and among the aims include an assessment of the developmental trajectory of mental disorders. This level of international cooperation helps transfer research findings to new social contexts as well as enabling an assessment of which findings can be replicated, and which interventions are most effective, in different social and cultural settings. However, data sharing across different regional and national health care systems requires a careful consideration of different standards in ethical research, data protection ...
Source: European Archives of Psychiatry and Clinical Neuroscience - July 28, 2020 Category: Neuroscience Source Type: research

Cortical activation abnormalities in bipolar and schizophrenia patients in a combined oddball-incongruence paradigm.
This study investigated the pathomechanisms underlying their deficits in cognitive control. A combined oddball-incongruence fMRI task was applied to examine similarities and differences of neural activation patterns between patients and healthy controls. Bipolar and schizophrenia patients demonstrated hyperactivations in the intraparietal cortex during the oddball condition. Furthermore, bipolar patients revealed diagnosis-specific hyperactivation in the left middle frontal gyrus, precentral gyrus, anteroventral prefrontal cortex and orbitofrontal cortex regions compared to schizophrenia patients and healthy individuals. I...
Source: European Archives of Psychiatry and Clinical Neuroscience - July 28, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research