Pain management and prevention of suicide in the COVID-19 era
(Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - March 5, 2021 Category: Neuroscience Source Type: research

Plasma calcium concentration during detoxification predicts neural cue-reactivity and craving during early abstinence in alcohol-dependent patients
Eur Arch Psychiatry Clin Neurosci. 2021 Feb 25. doi: 10.1007/s00406-021-01240-4. Online ahead of print.ABSTRACTRecent studies on the pathophysiology of alcohol dependence suggest a link between peripheral calcium concentrations and alcohol craving. Here, we investigated the association between plasma calcium concentration, cue-induced brain activation, and alcohol craving. Plasma calcium concentrations were measured at the onset of inpatient detoxification in a sample of N = 115 alcohol-dependent patients. Alcohol cue-reactivity was assessed during early abstinence (mean 11.1 days) using a functional magnetic resonance ima...
Source: European Archives of Psychiatry and Clinical Neuroscience - February 25, 2021 Category: Psychiatry Authors: Patrick Bach Rilana Schuster Anne Koopmann Sabine Vollstaedt-Klein Rainer Spanagel Falk Kiefer Source Type: research

Plasma calcium concentration during detoxification predicts neural cue-reactivity and craving during early abstinence in alcohol-dependent patients
AbstractRecent studies on the pathophysiology of alcohol dependence suggest a link between peripheral calcium concentrations and alcohol craving. Here, we investigated the association between plasma calcium concentration, cue-induced brain activation, and alcohol craving. Plasma calcium concentrations were measured at the onset of inpatient detoxification in a sample ofN = 115 alcohol-dependent patients. Alcohol cue-reactivity was assessed during early abstinence (mean 11.1 days) using a functional magnetic resonance imaging (fMRI) alcohol cue-reactivity task. Multiple regression analyses and bivariate c...
Source: European Archives of Psychiatry and Clinical Neuroscience - February 25, 2021 Category: Neuroscience Source Type: research

Efficacy of cognitive behavioural therapy in medicated adults with attention-deficit/hyperactivity disorder in multiple dimensions: a randomised controlled trial
Eur Arch Psychiatry Clin Neurosci. 2021 Feb 22. doi: 10.1007/s00406-021-01236-0. Online ahead of print.ABSTRACTThe study aimed to evaluate the efficacy of group cognitive behavioural therapy (CBT) in medicated adults with attention-deficit/hyperactivity disorder (ADHD) with a multidimensional evaluation and follow-up to week 36. Ninety-eight adult ADHD were randomly allocated to the CBT combined with medication (CBT + M) group or the medication (M) only group. The primary endpoint was the ADHD-Rating Scale (ADHD-RS). Secondary endpoints included emotional symptoms, self-esteem, automatic thoughts, quality of life (QoL), an...
Source: European Archives of Psychiatry and Clinical Neuroscience - February 22, 2021 Category: Psychiatry Authors: Mei-Rong Pan Shi-Yu Zhang Sun-Wei Qiu Lu Liu Hai-Mei Li Meng-Jie Zhao Min Dong Fei-Fei Si Yu-Feng Wang Qiu-Jin Qian Source Type: research

Efficacy of cognitive behavioural therapy in medicated adults with attention-deficit/hyperactivity disorder in multiple dimensions: a randomised controlled trial
AbstractThe study aimed to evaluate the efficacy of group cognitive behavioural therapy (CBT) in medicated adults with attention-deficit/hyperactivity disorder (ADHD) with a multidimensional evaluation and follow-up to week 36. Ninety-eight adult ADHD were randomly allocated to the CBT combined with medication (CBT  + M) group or the medication (M) only group. The primary endpoint was the ADHD–Rating Scale (ADHD-RS). Secondary endpoints included emotional symptoms, self-esteem, automatic thoughts, quality of life (QoL), and executive function (EF). The outcome measures were obtained at baseline (T1), af...
Source: European Archives of Psychiatry and Clinical Neuroscience - February 22, 2021 Category: Neuroscience Source Type: research

Postural sway and neurocognition in individuals meeting criteria for a clinical high-risk syndrome.
This study examined associations between the MATRICS cognitive battery, postural sway (an index of cerebellar functioning), and SIPS-RC psychosis risk scores in a CHR sample (N = 66). Poorer working memory and processing speed were associated with less postural control. Consistent with the cognitive dysmetria theory of schizophrenia, neurocognitive deficits are associated with cerebellar dysfunction in this critical population. PMID: 33606092 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - February 20, 2021 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

The benefits of emotionally salient cues on event-based prospective memory in bipolar patients and schizophrenia patients.
This study aimed to examine and compare the potential enhancement effect of emotional PM cues in schizophrenia patients and bipolar patients. Twenty-eight clinically stable schizophrenia participants, 26 euthymic bipolar participants and 29 controls completed a computerized PM task involving PM cues with different types of valences (i.e., positive, neutral and negative). All the three groups showed better PM performance when negative PM cues were presented compared with positive and neutral PM cues. The sizes of the enhancement effects of negative PM cues were large (all Cohen's d ≥ 1.00) and comparable ac...
Source: European Archives of Psychiatry and Clinical Neuroscience - February 19, 2021 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Neural signature of error processing in major depression.
Authors: Malejko K, Hafner S, Plener PL, Bonenberger M, Groen G, Abler B, Graf H Abstract The clinical presentation of major depression (MD) is heterogenous and comprises various affective and cognitive symptoms including an increased sensitivity to errors. Various electrophysiological but only few functional magnetic resonance imaging (fMRI) studies investigated neural error processing in MD with inconsistent findings. Thus, reliable evidence regarding neural signatures of error processing in patients with current MD is limited despite its potential relevance as viable neurobiological marker of psychopathology. We...
Source: European Archives of Psychiatry and Clinical Neuroscience - February 19, 2021 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Postural sway and neurocognition in individuals meeting criteria for a clinical high-risk syndrome
This study examined associations between the MATRICS cognitive battery, postural sway (an index of cerebellar functioning), and SIPS-RC psychosis risk scores in a CHR sample (N = 66). Poorer working memory and processing speed were associated with less postural control. Consistent with the cognitive dysmetria theory of schizophrenia, neurocognitive deficits are associated with cerebellar dysfunction in this critical population. (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - February 19, 2021 Category: Neuroscience Source Type: research

Neural signature of error processing in major depression
AbstractThe clinical presentation of major depression (MD) is heterogenous and comprises various affective and cognitive symptoms including an increased sensitivity to errors. Various electrophysiological but only few functional magnetic resonance imaging (fMRI) studies investigated neural error processing in MD with inconsistent findings. Thus, reliable evidence regarding neural signatures of error processing in patients with current MD is limited despite its potential relevance as viable neurobiological marker of psychopathology. We therefore investigated a sample of 16 young adult female patients with current MD and 17 ...
Source: European Archives of Psychiatry and Clinical Neuroscience - February 17, 2021 Category: Neuroscience Source Type: research

The benefits of emotionally salient cues on event-based prospective memory in bipolar patients and schizophrenia patients
This study aimed to examine and compare the potential enhancement effect of emotional PM cues in schizophrenia patients and bipolar patients. Twenty-eight clinically stable schizophrenia participants, 26 euthymic bipolar participants and 29 controls completed a computerized PM task involving PM cues with different types of valences (i.e., positive, neutral and negative). All the three groups showed better PM performance when negative PM cues were presented compared with positive and neutral PM cues. The sizes of the enhancement effects of negative PM cues were large (all Cohen ’sd ≥ 1.00) and compara...
Source: European Archives of Psychiatry and Clinical Neuroscience - February 16, 2021 Category: Neuroscience Source Type: research

Religiosity and prevalence of suicide, psychiatric disorders and psychotic symptoms in the French general population.
Authors: Brito MA, Amad A, Rolland B, Geoffroy PA, Peyre H, Roelandt JL, Benradia I, Thomas P, Vaiva G, Schürhoff F, Pignon B Abstract We aimed to examine the association between religious beliefs and observance and the prevalence of psychiatric disorders, psychotic symptoms and history of suicide attempts in the French general population. The cross-sectional survey interviewed 38,694 subjects between 1999 and 2003, using the MINI. Current religious beliefs and observance were identified by means of two questions: "are you a believer?" and "are you religiously observant?". We studied the as...
Source: European Archives of Psychiatry and Clinical Neuroscience - February 12, 2021 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Religiosity and prevalence of suicide, psychiatric disorders and psychotic symptoms in the French general population
AbstractWe aimed to examine the association between religious beliefs and observance and the prevalence of psychiatric disorders, psychotic symptoms and history of suicide attempts in the French general population. The cross-sectional survey interviewed 38,694 subjects between 1999 and 2003, using the MINI. Current religious beliefs and observance were identified by means of two questions: “are you a believer?” and “are you religiously observant?”. We studied the association between religiosity and psychiatric outcomes using a multivariable logistic regression model adjusted for sociodemographic cha...
Source: European Archives of Psychiatry and Clinical Neuroscience - February 10, 2021 Category: Neuroscience Source Type: research

Peripandemic psychiatric emergencies: impact of the COVID-19 pandemic on patients according to diagnostic subgroup.
This study aims to present the immediate effects of the pandemic on patients presenting in the psychiatric emergency department (PED) of Hannover Medical School. Patients presenting during the same timeframe in 2019 served as a control group. A decrease in PED visits was observed during the COVID-19 pandemic with an increase in repeat visits within 1 month (30.2 vs. 20.4%, pBA = 0.001). Fewer patients with affective disorders utilized the PED (15.2 vs. 22.2%, pBA = 0.010). Suicidal ideation was stated more frequently among patients suffering from substance use disorders (47.4 vs. 26.8%, pBA...
Source: European Archives of Psychiatry and Clinical Neuroscience - February 8, 2021 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Distress severity in perceptual anomalies moderates the relationship between prefrontal brain structure and psychosis proneness in nonclinical individuals.
Authors: Evermann U, Schmitt S, Meller T, Pfarr JK, Grezellschak S, Nenadić I Abstract In the general population, psychosis risk phenotypes occur independently of attenuated prodromal syndromes. Neurobiological correlates of vulnerability could help to understand their meaningfulness. Interactions between the occurrence of psychotic-like experiences (PLE) and other psychological factors e.g., distress related to PLE, may distinguish psychosis-prone individuals from those without risk of future psychotic disorder. We aimed to investigate whether (a) correlates of total PLE and distress, and (b) symptom dimension-sp...
Source: European Archives of Psychiatry and Clinical Neuroscience - February 5, 2021 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Peripandemic psychiatric emergencies: impact of the COVID-19 pandemic on patients according to diagnostic subgroup
This study aims to present the immediate effects of the pandemic on patients presenting in the psychiatric emergency department (PED) of Hannover Medical School. Patients presenting during the same timeframe in 2019 served as a control group. A decrease in PED visits was observed during the COVID-19 pandemic with an increase in repeat visits within 1  month (30.2 vs. 20.4%,pBA = 0.001). Fewer patients with affective disorders utilized the PED (15.2 vs. 22.2%,pBA = 0.010). Suicidal ideation was stated more frequently among patients suffering from substance use disorders (47.4 vs. 26.8%,pBA&t...
Source: European Archives of Psychiatry and Clinical Neuroscience - February 5, 2021 Category: Neuroscience Source Type: research

Distress severity in perceptual anomalies moderates the relationship between prefrontal brain structure and psychosis proneness in nonclinical individuals
AbstractIn the general population, psychosis risk phenotypes occur independently of attenuated prodromal syndromes. Neurobiological correlates of vulnerability could help to understand their meaningfulness. Interactions between the occurrence of psychotic-like experiences (PLE) and other psychological factors e.g., distress related to PLE, may distinguish psychosis-prone individuals from those without risk of future psychotic disorder. We aimed to investigate whether (a) correlates of total PLE and distress, and (b) symptom dimension-specific moderation effects exist at the brain structural level in non-help-seeking adults...
Source: European Archives of Psychiatry and Clinical Neuroscience - February 2, 2021 Category: Neuroscience Source Type: research

Reduced ribosomal DNA transcription in the prefrontal cortex of suicide victims: consistence of new molecular RT-qPCR findings with previous morphometric data from AgNOR-stained pyramidal neurons.
Authors: Krzyżanowska M, Rębała K, Steiner J, Kaliszan M, Pieśniak D, Karnecki K, Wiergowski M, Brisch R, Braun K, Jankowski Z, Kosmowska M, Chociej J, Gos T Abstract Prefrontal cortical regions play a key role in behavioural regulation, which is profoundly disturbed in suicide. The study was carried out on frozen cortical samples from the anterior cingulate cortex (dorsal and ventral parts, ACd and ACv), the orbitofrontal cortex (OFC), and the dorsolateral cortex (DLC) obtained from 20 suicide completers (predominantly violent) with unknown psychiatric diagnosis and 21 non-suicidal controls. The relative level...
Source: European Archives of Psychiatry and Clinical Neuroscience - January 29, 2021 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Reduced ribosomal DNA transcription in the prefrontal cortex of suicide victims: consistence of new molecular RT-qPCR findings with previous morphometric data from AgNOR-stained pyramidal neurons
AbstractPrefrontal cortical regions play a key role in behavioural regulation, which is profoundly disturbed in suicide. The study was carried out on frozen cortical samples from the anterior cingulate cortex (dorsal and ventral parts, ACd and ACv), the orbitofrontal cortex (OFC), and the dorsolateral cortex (DLC) obtained from 20 suicide completers (predominantly violent) with unknown psychiatric diagnosis and 21 non-suicidal controls. The relative level of ribosomal RNA (rRNA) as a marker of the transcriptional activity of ribosomal DNA (rDNA) was evaluated bilaterally in prefrontal regions mentioned above (i.e. in eight...
Source: European Archives of Psychiatry and Clinical Neuroscience - January 26, 2021 Category: Neuroscience Source Type: research

Mindreading and metacognition patterns in patients with borderline personality disorder: experimental study.
Authors: Cyrkot T, Szczepanowski R, Jankowiak-Siuda K, Gawęda Ł, Cichoń E Abstract Current psychopathology attempts to understand personality disorders in relation to deficits in higher cognition such as mindreading and metacognition. Deficits in mindreading are usually related to limitations in or a complete lack of the capacity to understand and attribute mental states to others, while impairments in metacognition concern dysfunctional control and monitoring of one's own processes. The present study investigated dysfunctional higher cognition in the population of patients with borderline personality disor...
Source: European Archives of Psychiatry and Clinical Neuroscience - January 20, 2021 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Mindreading and metacognition patterns in patients with borderline personality disorder: experimental study
AbstractCurrent psychopathology attempts to understand personality disorders in relation to deficits in higher cognition such as mindreading and metacognition. Deficits in mindreading are usually related to limitations in or a complete lack of the capacity to understand and attribute mental states to others, while impairments in metacognition concern dysfunctional control and monitoring of one ’s own processes. The present study investigated dysfunctional higher cognition in the population of patients with borderline personality disorder (BPD) by analyzing the accuracy of metacognitive judgments in a mindreading...
Source: European Archives of Psychiatry and Clinical Neuroscience - January 18, 2021 Category: Neuroscience Source Type: research

Non-invasive brain stimulation: the next frontier in psychiatry.
Authors: Walther S, Baeken C PMID: 33433677 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - January 14, 2021 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Neural rhythm in the retrosplenial cortex during ketamine-induced dissociation.
Authors: Hashimoto K PMID: 33433678 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - January 14, 2021 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Prejudices in the psychopathologist: Karl Jaspers' heritage.
Authors: Jerotic S Abstract Contributions of Karl Jaspers to the discipline of psychopathology are numerous. One of his most important insights deals with the method of interviewing in psychopathology. Specifically, how an interviewer (i.e. psychopathologist) approaches and explores mental phenomena that present themselves in the person being interviewed. By cultivating a phenomenological attitude, clinicians also acquire and renew self-criticism (Selbskritik), an essential aspect of a true psychopathologist. A fundamental part of the critical attitude in descriptive psychopathology is the re-examination of prejudi...
Source: European Archives of Psychiatry and Clinical Neuroscience - January 13, 2021 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Neural rhythm in the retrosplenial cortex during ketamine-induced dissociation
(Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - January 12, 2021 Category: Neuroscience Source Type: research

Non-invasive brain stimulation: the next frontier in psychiatry
(Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - January 12, 2021 Category: Neuroscience Source Type: research

Prejudices in the psychopathologist: Karl Jaspers ’ heritage
AbstractContributions of Karl Jaspers to the discipline of psychopathology are numerous. One of his most important insights deals with the method of interviewing in psychopathology. Specifically, how an interviewer (i.e. psychopathologist) approaches and explores mental phenomena that present themselves in the person being interviewed. By cultivating a phenomenological attitude, clinicians also acquire and renew self-criticism (Selbskritik), an essential aspect of a true psychopathologist. A fundamental part of the critical attitude in descriptive psychopathology is the re-examination of prejudices present in psychopatholo...
Source: European Archives of Psychiatry and Clinical Neuroscience - January 11, 2021 Category: Neuroscience Source Type: research

Repurposing of CNS drugs to treat COVID-19 infection: targeting the sigma-1 receptor.
Authors: Hashimoto K Abstract The novel coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The escalating number of SARS-CoV-2-infected individuals has conferred the viral spread with the status of global pandemic. However, there are no prophylactic or therapeutic drugs available on the market to treat COVID-19, although several drugs have been approved. Recently, two articles using the comparative viral-human protein-protein interaction map revealed that the sigma-1 receptor in the endoplasmic reticulum plays an important role in SARS-CoV-2 replication in...
Source: European Archives of Psychiatry and Clinical Neuroscience - January 7, 2021 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Repurposing of CNS drugs to treat COVID-19 infection: targeting the sigma-1 receptor
AbstractThe novel coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The escalating number of SARS-CoV-2-infected individuals has conferred the viral spread with the status of global pandemic. However, there are no prophylactic or therapeutic drugs available on the market to treat COVID-19, although several drugs have been approved. Recently, two articles using the comparative viral-human protein –protein interaction map revealed that the sigma-1 receptor in the endoplasmic reticulum plays an important role in SARS-CoV-2 replication in cells. Knockout and kn...
Source: European Archives of Psychiatry and Clinical Neuroscience - January 5, 2021 Category: Neuroscience Source Type: research

Working memory associated with anti-suicidal ideation effect of repeated-dose intravenous ketamine in depressed patients.
The objective of current study was to illuminate the relationship between WM and SI in MDD with repeated ketamine treatment. MDD patients with SI (n = 59) and without SI (n = 37) completed six intravenous infusions of ketamine (0.5 mg/kg over 40 min) over 12 days (Day 1, 3, 5, 8, 10 and 12). The severity of depressive symptoms, SI and WM were assessed at baseline, day 13 and day 26. We found that WM was significantly improved after 6 ketamine infusions (F = 161.284, p = 0.009) in a linear mixed model. Correlation analysis showed that the improvement of ...
Source: European Archives of Psychiatry and Clinical Neuroscience - January 4, 2021 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Aberrant brain network topology in the frontoparietal-limbic circuit in bipolar disorder: a graph-theory study.
In this study, graph theoretical methods were used to examine global, modular and nodal brain network topology in the resting state using functional magnetic resonance imaging data acquired from 95 participants, including those with bipolar depression (BPD; n = 30) and bipolar mania (BPM; n = 39) and healthy control (HC) subjects (n = 26). The threshold value of the individual subjects' connectivity matrix varied from 0.15 to 0.30 with steps of 0.01. We found that: (1) at the global level, BP patients showed a significantly increased global efficiency and synchronization and a decr...
Source: European Archives of Psychiatry and Clinical Neuroscience - January 4, 2021 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

The prevention of suicide among military veterans during the COVID-19 pandemic.
Authors: Levine J, Sher L PMID: 33389056 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - January 4, 2021 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Co-occurrence of schizo-obsessive traits and its correlation with altered executive control network functional connectivity.
In this study, we recruited 30 schizotypal individuals, 25 individuals with OCS, 29 individuals with SOT and 29 controls for a resting-state ECN-related functional connectivity (rsFC) and a go/shift/no-go task. We found that individuals with SOT exhibited increased rsFC within the ECN compared with controls, while schizotypal individuals exhibited the opposite. Individuals with OCS exhibited decreased rsFC within the ECN and between the ECN and the default mode network (DMN), relative to controls. No significant correlational results between altered rsFC related to the ECN with executive function performance were found aft...
Source: European Archives of Psychiatry and Clinical Neuroscience - January 4, 2021 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Enhancement of aerobic fitness improves social functioning in individuals with schizophrenia.
Authors: Kimhy D, Tay C, Vakhrusheva J, Beck-Felts K, Ospina LH, Ifrah C, Parvaz M, Gross JJ, Bartels MN Abstract Individuals with schizophrenia display substantial deficits in social functioning (SF), characterized by chronic, lifelong presentations. Yet, at present there are few effective interventions to enhance SF in this population. Emerging evidence from studies of clinical populations that display similar SF deficits suggests that aerobic exercise (AE) may improve social skills. However, this putative impact has not been investigated in schizophrenia. Employing a single-blind, randomized clinical trial desig...
Source: European Archives of Psychiatry and Clinical Neuroscience - January 4, 2021 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Enhancement of aerobic fitness improves social functioning in individuals with schizophrenia
AbstractIndividuals with schizophrenia display substantial deficits in social functioning (SF), characterized by chronic, lifelong presentations. Yet, at present there are few effective interventions to enhance SF in this population. Emerging evidence from studies of clinical populations that display similar SF deficits suggests that aerobic exercise (AE) may improve social skills. However, this putative impact has not been investigated in schizophrenia. Employing a single-blind, randomized clinical trial design, 33 individuals with schizophrenia were randomized to receive 12  weeks of Treatment-As-Usual (TAU;n&thinsp...
Source: European Archives of Psychiatry and Clinical Neuroscience - January 3, 2021 Category: Neuroscience Source Type: research

Co-occurrence of schizo-obsessive traits and its correlation with altered executive control network functional connectivity
In this study, we recruited 30 schizotypal individuals, 25 individuals with OCS, 29 individuals with SOT and 29 controls for a resting-state ECN-related functional connectivity (rsFC) and a go/shift/no-go task. We found that individuals with SOT exhibited increased rsFC within the ECN compared with controls , while schizotypal individuals exhibited the opposite. Individuals with OCS exhibited decreased rsFC within the ECN and between the ECN and the default mode network (DMN), relative to controls. No significant correlational results between altered rsFC related to the ECN with executive function perf ormance were found a...
Source: European Archives of Psychiatry and Clinical Neuroscience - January 3, 2021 Category: Neuroscience Source Type: research

The prevention of suicide among military veterans during the COVID-19 pandemic
(Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - January 2, 2021 Category: Neuroscience Source Type: research

Aberrant brain network topology in the frontoparietal-limbic circuit in bipolar disorder: a graph-theory study
In this study, graph theoretical methods were used to examine global, modular and nodal brain network topology in the resting state using functional magnetic resonance imaging data acquired from 95 participants, including those with bipolar depression (BPD;n = 30) and bipolar mania (BPM;n = 39) and healthy control (HC) subjects (n = 26). The threshold value of the individual subjects’ connectivity matrix varied from 0.15 to 0.30 with steps of 0.01. We found that: (1) at the global level, BP patients showed a significantly increased global efficiency and synchronization and a ...
Source: European Archives of Psychiatry and Clinical Neuroscience - January 2, 2021 Category: Neuroscience Source Type: research

Working memory associated with anti-suicidal ideation effect of repeated-dose intravenous ketamine in depressed patients
The objective of current study was to illuminate the relationship between WM and SI in MDD with repeated ketamine treatment. MDD patients with SI (n = 59) and without SI (n = 37) completed six intravenous infusions of ketamine (0.5 mg/kg over 40 min) over 12 days (Day 1, 3, 5, 8, 10 and 12). The severity of depressive symptoms, SI and WM were assessed at baseline, day 13 and day 26. We found that WM was significantly improved after 6 ketamine infusions (F = 161.284,p = 0.009) in a linear mixed model. Correlation analysis showed that the improvement of d...
Source: European Archives of Psychiatry and Clinical Neuroscience - January 1, 2021 Category: Neuroscience Source Type: research

BDNF influences neural cue-reactivity to food stimuli and food craving in obesity.
Authors: Bumb JM, Bach P, Grosshans M, Wagner X, Koopmann A, Vollstädt-Klein S, Schuster R, Wiedemann K, Kiefer F Abstract There is increasing evidence that brain-derived neurotrophic factor (BDNF) impacts on the development of obesity. We are the first to test the hypothesis that BDNF levels might be associated with neural reactivity to food cues in patients suffering from obesity and healthy controls. We assessed visual food cue-induced neural response in 19 obese patients and 20 matched controls using functional magnetic resonance imaging and analyzed the associations between BDNF levels, food cue-reactivit...
Source: European Archives of Psychiatry and Clinical Neuroscience - December 30, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Pharmacotherapy of 1,044 inpatients with posttraumatic stress disorder: current status and trends in German-speaking countries.
Authors: Reinhard MA, Seifert J, Greiner T, Toto S, Bleich S, Grohmann R Abstract Posttraumatic stress disorder (PTSD) is a debilitating psychiatric disorder with limited approved pharmacological treatment options and high symptom burden. Therefore, real-life prescription patterns may differ from guideline recommendations, especially in psychiatric inpatient settings. The European Drug Safety Program in Psychiatry ("Arzneimittelsicherheit in der Psychiatrie", AMSP) collects inpatients' prescription rates cross-sectionally twice a year in German-speaking psychiatric hospitals. For this study, the AMSP data...
Source: European Archives of Psychiatry and Clinical Neuroscience - December 30, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Pharmacotherapy of 1,044 inpatients with posttraumatic stress disorder: current status and trends in German-speaking countries
AbstractPosttraumatic stress disorder (PTSD) is a debilitating psychiatric disorder with limited approved pharmacological treatment options and high symptom burden. Therefore, real-life prescription patterns may differ from guideline recommendations, especially in psychiatric inpatient settings. The European Drug Safety Program in Psychiatry ( “Arzneimittelsicherheit in der Psychiatrie”, AMSP) collects inpatients’ prescription rates cross-sectionally twice a year in German-speaking psychiatric hospitals. For this study, the AMSP database was screened for psychiatric inpatients with a primary diagnosis of ...
Source: European Archives of Psychiatry and Clinical Neuroscience - December 28, 2020 Category: Neuroscience Source Type: research

BDNF influences neural cue-reactivity to food stimuli and food craving in obesity
AbstractThere is increasing evidence that brain-derived neurotrophic factor (BDNF) impacts on the development of obesity. We are the first to test the hypothesis that BDNF levels might be associated with neural reactivity to food cues in patients suffering from obesity and healthy controls. We assessed visual food cue-induced neural response in 19 obese patients and 20 matched controls using functional magnetic resonance imaging and analyzed the associations between BDNF levels, food cue-reactivity and food craving. Whole-brain analysis in both groups revealed that food cues elicited higher neural activation in clusters of...
Source: European Archives of Psychiatry and Clinical Neuroscience - December 26, 2020 Category: Neuroscience Source Type: research