Brain activity and connectivity differences in reward value discrimination during effort computation in schizophrenia
AbstractNegative symptoms in the motivational domain are strongly correlated with deficits in social and occupational functioning in schizophrenia. However, the neural substrates underlying these symptoms remain largely unknown. Twenty-eight adults with schizophrenia and twenty healthy volunteers underwent functional magnetic resonance while completing a lottery game designed to capture reward-related cognitive processes. Each trial demanded an initial investment of effort in form of key presses to increase the odds of winning. Brain activity in response to different reward cues (1 euro versus 1 cent) was compared between ...
Source: European Archives of Psychiatry and Clinical Neuroscience - June 3, 2020 Category: Neuroscience Source Type: research

Risk of neuropsychiatric disorders in offspring of COVID-19-infected pregnant women and nutritional intervention
(Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - June 2, 2020 Category: Neuroscience Source Type: research

Is twice daily LF-rTMS a viable treatment option for treatment-resistant OCD? Results from an open-label feasibility study.
This study aimed to evaluate the safety and efficacy of rTMS targeting the dmPFC in the treatment of treatment-resistant OCD patients. Twelve patients received 20 sessions of low-frequency (LF) rTMS (1 Hz, 1200 pulses) in a twice daily protocol during 10 weekdays. Y-BOCS and IDS scores modestly but significantly decreased after treatment and at follow-up and HADS anxiety improved at follow-up. LF rTMS may improve OCD, anxiety, and depressive symptoms in treatment-resistant OCD and was a safe and well-tolerated treatment. PMID: 32472148 [PubMed - as supplied by publisher] (Source: European Archives of Psychiat...
Source: European Archives of Psychiatry and Clinical Neuroscience - June 1, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Transcranial direct current stimulation and emotion processing deficits in psychosis and depression
AbstractEmotional processing deficits (EPDs) are commonly observed among individuals diagnosed with (1) psychotic disorders (2) and depression. Given that EPDs can impact overall functioning and quality of life, the need to identify effective interventions is critical. To date, our current understanding of treatments for these impairments is limited. However, there is increasing interest in investigating the efficacy of transcranial direct current stimulation (tDCS). This neuromodulation technique releases a weak electrical current through the brain. Given research suggesting promise for using tDCS to improve symptoms and ...
Source: European Archives of Psychiatry and Clinical Neuroscience - June 1, 2020 Category: Neuroscience Source Type: research

Repeated bullying at the workplace in medical students and young doctors: the MESSIAEN national study.
Authors: Messiaen M, Duba A, Boulangeat C, Boucekine M, Bourbon A, Viprey M, Auquier P, Lançon C, Boyer L, Fond G Abstract Despite clues indicating high Bullying at the Work Place (BWP) rates in French hospitals, there has been no quantitative study so far. To determine the prevalence of repeated BWP in a national sample of French young physicians; its risk factors, and the mental health consequences of BWP. The study is a cross-sectional observational epidemiological national study addressed to young physicians. The online internet anonymous questionnaire was elaborated according to previous studies explori...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 30, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Is twice daily LF-rTMS a viable treatment option for treatment-resistant OCD? Results from an open-label feasibility study
This study aimed to evaluate the safety and efficacy of rTMS targeting the dmPFC in the treatment of treatment-resistant OCD patients. Twelve patients received 20 sessions of low-frequency (LF) rTMS (1  Hz, 1200 pulses) in a twice daily protocol during 10 weekdays. Y-BOCS and IDS scores modestly but significantly decreased after treatment and at follow-up and HADS anxiety improved at follow-up. LF rTMS may improve OCD, anxiety, and depressive symptoms in treatment-resistant OCD and was a safe an d well-tolerated treatment. (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - May 29, 2020 Category: Neuroscience Source Type: research

A web-based adapted physical activity program (e-APA) versus health education program (e-HE) in patients with schizophrenia and healthy volunteers: study protocol for a randomized controlled trial (PEPSY V@Si).
Authors: Tréhout M, Leroux E, Bigot L, Jego S, Leconte P, Reboursière E, Morello R, Chapon PA, Herbinet A, Quarck G, Dollfus S Abstract Patients with schizophrenia (SZ) have a high level of cardiovascular morbidity and some clinical symptoms of illness remain resistant to pharmacological approaches. A large number of studies support the effectiveness of physical activity (PA) in SZ. The aims of this trial is to assess the effects of a remote, web-based adapted PA program (e-APA) compared to a health education program (e-HE) on brain plasticity in SZ and healthy volunteers (HV) and on psychiatric, neur...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 28, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

First episode psychosis: register-based study of comorbid psychiatric disorders and medications before and after.
In conclusion, most cases with a first psychosis hospitalization had clinical presentations indicating comorbid psychiatric disorders. Cases with comorbidity had a higher risk for re-hospitalizations. PMID: 32458108 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - May 28, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Three types of psychotic-like experiences in youth at clinical high risk for psychosis.
CONCLUSIONS:  Three types of PLEs were valid in this CHR sample. Self-reported PLEs may be used not only to screen individuals for inclusion in the CHR classification, but also to characterize individuals within this population. Self-reported PLEs may help to forecast which CHR individuals will progress toward psychotic illness. PMID: 32458109 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - May 28, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

A pilot investigation of accelerated deep transcranial magnetic stimulation protocols in treatment-resistant depression.
Authors: Filipčić I, Šimunović Filipčić I, Sučić S, Milovac Ž, Gereš N, Matić K, Čelić-Ružić M, Zečević Penić S, Orgulan I, Požgaj V, Bajić Ž Abstract Accelerated repetitive transcranial magnetic stimulation (rTMS) protocols are being increasingly studied because of their potential to provide quicker and enhanced treatment efficacy. However, there is a lack of accelerated deep TMS with H1-coil (adTMS) treatment research. This randomized pilot study investigated the efficacy and safety of adTMS protocols. Twenty-eight TRD patients received 20-min sessions twice daily for 10 or 15&nbs...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 27, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Repeated bullying at the workplace in medical students and young doctors: the MESSIAEN national study
AbstractDespite clues indicating high Bullying at the Work Place (BWP) rates in French hospitals, there has been no quantitative study so far. To determine the prevalence of repeated BWP in a national sample of French young physicians; its risk factors, and the mental health consequences of BWP. The study is a cross-sectional observational epidemiological national study addressed to young physicians. The online internet anonymous questionnaire was elaborated according to previous studies exploring BWP. In addition, we explored the quality of initial training. BWP was defined according to the French legal definition. Mental...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 27, 2020 Category: Neuroscience Source Type: research

Three types of psychotic-like experiences in youth at clinical high risk for psychosis
Conclusions: Three types of PLEs were valid in this CHR sample. Self-reported PLEs may be used not only to screen individuals for inclusion in the CHR classification, but also to characterize individuals within this population. Self-reported PLEs may help to forecast which CHR individuals will progress toward psychotic illness. (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - May 26, 2020 Category: Neuroscience Source Type: research

First episode psychosis: register-based study of comorbid psychiatric disorders and medications before and after
In conclusion, most cases with a first psychosis hospitalization had clinical presentations indicating co morbid psychiatric disorders. Cases with comorbidity had a higher risk for re-hospitalizations. (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - May 26, 2020 Category: Neuroscience Source Type: research

A web-based adapted physical activity program (e-APA) versus health education program (e-HE) in patients with schizophrenia and healthy volunteers: study protocol for a randomized controlled trial (PEPSY V@Si)
AbstractPatients with schizophrenia (SZ) have a high level of cardiovascular morbidity and some clinical symptoms of illness remain resistant to pharmacological approaches. A large number of studies support the effectiveness of physical activity (PA) in SZ. The aims of this trial is to assess the effects of a remote, web-based adapted PA program (e-APA) compared to a health education program (e-HE) on brain plasticity in SZ and healthy volunteers (HV) and on psychiatric, neurocognitive, circadian and physical variables. The study is an interventional, multicenter, randomized open-label trial. Forty-two SZ will be randomize...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 26, 2020 Category: Neuroscience Source Type: research

A pilot investigation of accelerated deep transcranial magnetic stimulation protocols in treatment-resistant depression
AbstractAccelerated repetitive transcranial magnetic stimulation (rTMS) protocols are being increasingly studied because of their potential to provide quicker and enhanced treatment efficacy. However, there is a lack of accelerated deep TMS with H1-coil (adTMS) treatment research. This randomized pilot study investigated the efficacy and safety of adTMS protocols. Twenty-eight TRD patients received 20-min sessions twice daily for 10 or 15  days. Primary outcomes were changes in Hamilton Depression Rating Scale (HDRS) scores and discontinuation because of adverse events (AE). Secondary outcomes were response, remission...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 24, 2020 Category: Neuroscience Source Type: research

The COVID-19  pandemic brings a second wave of social isolation and disrupted services.
The COVID-19 pandemic brings a second wave of social isolation and disrupted services. Eur Arch Psychiatry Clin Neurosci. 2020 May 15;: Authors: Stefana A, Youngstrom EA, Hopwood CJ, Dakanalis A PMID: 32415510 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - May 18, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Neurological soft signs and cognition in the late course of chronic schizophrenia: a longitudinal study.
Authors: Herold CJ, Duval CZ, Schröder J Abstract Neurological soft signs (NSS) are minor ('soft') neurological abnormalities in sensory and motor performances, which are frequently reported in patients with schizophrenia at any stage of their illness. It has been demonstrated that NSS vary in the clinical course of the disorder: longitudinally NSS decrease in parallel with remission of psychopathological symptoms, an effect which mainly applies to patients with a remitting course. These findings are primarily based on patients with a first episode of the disorder, while the course of NSS in patients with chro...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 18, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Neurological soft signs and cognition in the late course of chronic schizophrenia: a longitudinal study
AbstractNeurological soft signs (NSS) are minor ( ‘soft’) neurological abnormalities in sensory and motor performances, which are frequently reported in patients with schizophrenia at any stage of their illness. It has been demonstrated that NSS vary in the clinical course of the disorder: longitudinally NSS decrease in parallel with remission of psychopathological symptoms, an effect which mainly applies to patients with a remitting course. These findings are primarily based on patients with a first episode of the disorder, while the course of NSS in patients with chronic schizophrenia and persisting symptoms ...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 16, 2020 Category: Neuroscience Source Type: research

Correction to: Migration and  schizophrenia: meta-analysis and explanatory framework.
Correction to: Migration and schizophrenia: meta-analysis and explanatory framework. Eur Arch Psychiatry Clin Neurosci. 2020 May 12;: Authors: Henssler J, Brandt L, Müller M, Liu S, Montag C, Sterzer P, Heinz A Abstract In the original article, the reference number #36 is listed. PMID: 32399611 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - May 15, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

The COVID-19  pandemic brings a second wave of social isolation and disrupted services
(Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - May 15, 2020 Category: Neuroscience Source Type: research

Upscaling e-mental health in Europe: a six-country qualitative analysis and policy recommendations from the eMEN project.
Authors: Gaebel W, Lukies R, Kerst A, Stricker J, Zielasek J, Diekmann S, Trost N, Gouzoulis-Mayfrank E, Bonroy B, Cullen K, Desie K, Ewalds Mulliez AP, Gerlinger G, Günther K, Hiemstra HJ, McDaid S, Murphy C, Sander J, Sebbane D, Roelandt JL, Thorpe L, Topolska D, Van Assche E, Van Daele T, Van den Broeck L, Versluis C, Vlijter O Abstract E-mental health (eMH) encompasses the use of digital technologies to deliver, support, or enhance mental health services. Despite the growing evidence for the effectiveness of eMH interventions, the process of implementation of eMH solutions in healthcare remains slow throug...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 14, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Correction to: Migration and  schizophrenia: meta-analysis and explanatory framework
In the original article, the reference number #36 is listed. (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - May 12, 2020 Category: Neuroscience Source Type: research

Longitudinal effects of rTMS on neuroplasticity in chronic treatment-resistant depression.
Authors: Dalhuisen I, Ackermans E, Martens L, Mulders P, Bartholomeus J, de Bruijn A, Spijker J, van Eijndhoven P, Tendolkar I Abstract Major depressive disorder (MDD) is amongst the most prevalent of psychiatric disorders. Unfortunately, a third of patients will not respond to conventional treatments and suffer from treatment-resistant depression (TRD). Repetitive transcranial magnetic stimulation (rTMS) has been proven effective in treating TRD. The research suggests that rTMS acts via neuroplastic effects on the brain, which can be measured by changes in hippocampal and amygdala volume as well as cortical thickn...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 11, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Upscaling e-mental health in Europe: a six-country qualitative analysis and policy recommendations from the eMEN project
AbstractE-mental health (eMH) encompasses the use of digital technologies to deliver, support, or enhance mental health services. Despite the growing evidence for the effectiveness of eMH interventions, the process of implementation of eMH solutions in healthcare remains slow throughout Europe. To address this issue, the e-Mental Health Innovation and Transnational Implementation Platform North-West Europe (eMEN) project was initiated to increase the dissemination and quality of eMH services in Europe. In this project, status analyses regarding eMH in the six participating countries (i.e., Belgium, France, Germany, Ireland...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 11, 2020 Category: Neuroscience Source Type: research

Neural basis of shame and guilt experience in women with borderline personality disorder.
Authors: Göttlich M, Westermair AL, Beyer F, Bußmann ML, Schweiger U, Krämer UM Abstract Borderline personality disorder (BPD) is characterized by instability of affect, emotion dysregulation, and interpersonal dysfunction. Especially shame and guilt, so-called self-conscious emotions, are of central clinical relevance to BPD. However, only few experimental studies have focused on shame or guilt in BPD and none investigated their neurobiological underpinnings. In the present functional magnetic resonance imaging study, we took a scenario-based approach to experimentally induce feelings of shame, gui...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 9, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Inflammation, hippocampal volume, and cognition in schizophrenia: results from the Northern Finland Birth Cohort 1966.
Authors: Miller BJ, Herzig KH, Jokelainen J, Karhu T, Keinänen-Kiukaanniemi S, Järvelin MR, Veijola J, Viinamäki H, Päivikki Tanskanen, Jääskeläinen E, Isohanni M, Timonen M Abstract Increased blood interleukin-6 (IL-6) levels are a replicated abnormality in schizophrenia, and may be associated with smaller hippocampal volumes and greater cognitive impairment. These findings have not been investigated in a population-based birth cohort. The general population Northern Finland Birth Cohort 1966 was followed until age 43. Subjects with schizophrenia were identified through the natio...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 9, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Longitudinal effects of rTMS on neuroplasticity in chronic treatment-resistant depression
AbstractMajor depressive disorder (MDD) is amongst the most prevalent of psychiatric disorders. Unfortunately, a third of patients will not respond to conventional treatments and suffer from treatment-resistant depression (TRD). Repetitive transcranial magnetic stimulation (rTMS) has been proven effective in treating TRD. The research suggests that rTMS acts via neuroplastic effects on the brain, which can be measured by changes in hippocampal and amygdala volume as well as cortical thickness. This sham-controlled study investigates longitudinal effects of rTMS on the volumes of the hippocampus and amygdala and cortical th...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 9, 2020 Category: Neuroscience Source Type: research

Prevalence and associated factors of cannabis consumption in medical students: the BOURBON nationwide study.
The objective of the study is to determine the prevalence of cannabis consumption and cannabis use disorder (CUD) among French medical students and their association with psychotropic drug consumption and psychosocial factors. Medical students were recruited from 35 French universities of medicine through administration mailing lists and social networks, between December 2016 and May 2017. Cannabis consumption was self-declared by anonymous questionnaire and CUD was defined by a Cannabis Abuse Screening Test (CAST) score ≥ 3. 10,985 medical students with a mean age of 21.8 years (± 3.3) ...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 8, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Inflammation, hippocampal volume, and cognition in schizophrenia: results from the Northern Finland Birth Cohort 1966
AbstractIncreased blood interleukin-6 (IL-6) levels are a replicated abnormality in schizophrenia, and may be associated with smaller hippocampal volumes and greater cognitive impairment. These findings have not been investigated in a population-based birth cohort. The general population Northern Finland Birth Cohort 1966 was followed until age 43. Subjects with schizophrenia were identified through the national Finnish Care Register. Blood IL-6 levels were measured inn = 82 subjects with schizophrenia andn = 5373 controls at age 31. Additionally, 31 patients with schizophrenia and 63 healthy co...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 7, 2020 Category: Neuroscience Source Type: research

Neural basis of shame and guilt experience in women with borderline personality disorder
AbstractBorderline personality disorder (BPD) is characterized by instability of affect, emotion dysregulation, and interpersonal dysfunction. Especially shame and guilt, so-called self-conscious emotions, are of central clinical relevance to BPD. However, only few experimental studies have focused on shame or guilt in BPD and none investigated their neurobiological underpinnings. In the present functional magnetic resonance imaging study, we took a scenario-based approach to experimentally induce feelings of shame, guilt, and disgust with neutral scenarios as control condition. We included 19 women with BPD (age 26.4 &thi...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 7, 2020 Category: Neuroscience Source Type: research

Inflammatory cytokines derived from peripheral blood contribute to the modified electroconvulsive therapy-induced cognitive deficits in major depressive disorder.
This study examined the profiles of cytokines, the memory function, and their association in MECT-treated MDD patients. Forty first-episode, drug-free MDD patients and 40 healthy controls were recruited. MECT was started with antidepressant treatment at a stable initial dose. The Wechsler Memory Scale (WMS) and Hamilton Rating Scale for Depression 17 (HRSD-17) were used to assess the cognitive function. MDD patients were divided into the memory impairment group (WMS 
Source: European Archives of Psychiatry and Clinical Neuroscience - May 5, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Mental health treatment online during the COVID-19 outbreak.
Authors: Hu N, Pan S, Sun J, Wang Z, Mao H PMID: 32361812 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - May 5, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Digital technology in psychiatry: towards the implementation of a true person-centered care in psychiatry?
Authors: Myin-Germeys I PMID: 32363502 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - May 5, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Prevalence and associated factors of cannabis consumption in medical students: the BOURBON nationwide study
The objective of the study is to determine the prevalence of cannabis consumption and cannabis use disorder (CUD) among French medical students and their association with psychotropic drug consumption and psychosocial factors. Medical students were recruited from 35 French universities of medicine through administration mailing lists and social networks, between December 2016 and May 2017. Cannabis consumption was self-declared by anonymous questionnaire and CUD was defined by a Cannabis Abuse Screening Test (CAST) score  ≥ 3. 10,985 medical students with a mean age of 21.8 years (± 3.3)...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 5, 2020 Category: Neuroscience Source Type: research

Digital technology in psychiatry: towards the implementation of a true person-centered care in psychiatry?
(Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - May 3, 2020 Category: Neuroscience Source Type: research

Inflammatory cytokines derived from peripheral blood contribute to the modified electroconvulsive therapy-induced cognitive deficits in major depressive disorder
This study examined the profiles of cytokines, the memory function, and their association in MECT-treated MDD patients. Forty first-episode, drug-free MDD patients and 40 healthy controls were recruited. MECT was started with antidepressant treatment at a stable initial dose. The Wechsler Memory Scale (WMS) and Hamilton Rating Scale for Depression 17 (HRSD-17) were used to assess the cognitive function. MDD patients were divided into the memory impairment group (WMS  
Source: European Archives of Psychiatry and Clinical Neuroscience - May 2, 2020 Category: Neuroscience Source Type: research

Mental health treatment online during the COVID-19 outbreak
(Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - May 2, 2020 Category: Neuroscience Source Type: research

Functional near-infrared spectroscopy (fNIRS) as a tool to assist the diagnosis of major psychiatric disorders in a Chinese population.
Authors: Wei Y, Chen Q, Curtin A, Tu L, Tang X, Tang Y, Xu L, Qian Z, Zhou J, Zhu C, Zhang T, Wang J Abstract Advances in neuroimaging have promised the development of specific and objective biomarkers for the diagnosis and treatment of psychiatric disorders. Recently, functional near-infrared spectroscopy (fNIRS) has been used during cognitive tasks to measure cortical dysfunction associated with mental illnesses such as Schizophrenia (SCH), Major-Depressive disorder (MD) and Bipolar Disorder (BD). We investigated the ability of fNIRS as a clinically viable tool to successfully distinguish healthy individuals from...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 14, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Differential neural processing of unpleasant sensory stimulation in patients with major depression.
Authors: Malejko K, Brown RC, Plener PL, Bonenberger M, Graf H, Abler B Abstract An altered processing of negative salient stimuli has been suggested to play a central role in the pathophysiology of major depression (MD). Besides negative affective and social stimuli, physical pain as a subtype of negative sensory stimulation has been investigated in this context. However, the few neuroimaging studies on unpleasant sensory stimulation or pain processing in MD report heterogeneous findings. Here, we investigated 47 young females, 22 with MD and 25 healthy controls (HC) using fMRI (3.0 T). Four levels of increas...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 14, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Association between tDCS computational modeling and clinical outcomes in depression: data from the ELECT-TDCS trial.
Authors: Suen PJC, Doll S, Batistuzzo MC, Busatto G, Razza LB, Padberg F, Mezger E, Bulubas L, Keeser D, Deng ZD, Brunoni AR Abstract Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation intervention investigated for the treatment of depression. Clinical results have been heterogeneous, partly due to the variability of electric field (EF) strength in the brain owing to interindividual differences in head anatomy. Therefore, we investigated whether EF strength was correlated with behavioral changes in 16 depressed patients using simulated electric fields in real patient data from a cont...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 14, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Hazardous drinking is associated with hypnotic consumption in medical students in the BOURBON nationwide study: psychological factors explored.
Authors: Fond G, Bourbon A, Picot A, Boucekine M, Lançon C, Auquier P, Boyer L Abstract France has been identified with one of the highest rates of hazardous drinking and hypnotic consumption in Western countries. Medical students have been identified at risk for hazardous drinking yet we lacked of national data on their hypnotic consumption and associated factors to guide public health policies. To determine the prevalence of hazardous drinking and dependence among French medical students and their association with psychotropic drug consumption and psychosocial factors. Medical students were recruited from ...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 12, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Quality indicators for mental healthcare in the Danube region: results from a pilot feasibility study.
Authors: Gaebel W, Lehmann I, Chisholm D, Hinkov H, Höschl C, Kapócs G, Kurimay T, Tosevski DL, Milosavljevic M, Nakov V, Winkler P, Zielasek J Abstract Quality indicators are vital for monitoring the transformation of institution-based mental health services towards the provision of person-centered mental healthcare. While several mental healthcare quality indicators have been identified as relevant and valid, their actual usability and utility for routine monitoring healthcare quality over time is significantly determined by the availability and trustworthiness of the underlying data. In this feasibil...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 11, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Differential neural processing of unpleasant sensory stimulation in patients with major depression
AbstractAn altered processing of negative salient stimuli has been suggested to play a central role in the pathophysiology of major depression (MD). Besides negative affective and social stimuli, physical pain as a subtype of negative sensory stimulation has been investigated in this context. However, the few neuroimaging studies on unpleasant sensory stimulation or pain processing in MD report heterogeneous findings. Here, we investigated 47 young females, 22 with MD and 25 healthy controls (HC) using fMRI (3.0  T). Four levels of increasingly unpleasant electrical stimulation were applied. Ratings of stimulus intens...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 11, 2020 Category: Neuroscience Source Type: research

Functional near-infrared spectroscopy (fNIRS) as a tool to assist the diagnosis of major psychiatric disorders in a Chinese population
AbstractAdvances in neuroimaging have promised the development of specific and objective biomarkers for the diagnosis and treatment of psychiatric disorders. Recently, functional near-infrared spectroscopy (fNIRS) has been used during cognitive tasks to measure cortical dysfunction associated with mental illnesses such as Schizophrenia (SCH), Major-Depressive disorder (MD) and Bipolar Disorder (BD). We investigated the ability of fNIRS as a clinically viable tool to successfully distinguish healthy individuals from those with major psychiatric disorders. 316 patients with major psychiatric disorders (198 SCH/54 MD/64 BP) a...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 11, 2020 Category: Neuroscience Source Type: research

Association between tDCS computational modeling and clinical outcomes in depression: data from the ELECT-TDCS trial
AbstractTranscranial direct current stimulation (tDCS) is a non-invasive brain stimulation intervention investigated for the treatment of depression. Clinical results have been heterogeneous, partly due to the variability of electric field (EF) strength in the brain owing to interindividual differences in head anatomy. Therefore, we investigated whether EF strength was correlated with behavioral changes in 16 depressed patients using simulated electric fields in real patient data from a controlled clinical trial. We hypothesized that EF strength in the dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (A...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 11, 2020 Category: Neuroscience Source Type: research

AgNOR parameters of dorsal raphe nucleus neurons as a potential diagnostic tool which could aid the differentiation between suicidal and non-suicidal death.
Authors: Krzyżanowska M, Steiner J, Gos T PMID: 32266475 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - April 10, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Hazardous drinking is associated with hypnotic consumption in medical students in the BOURBON nationwide study: psychological factors explored
AbstractFrance has been identified with one of the highest rates of hazardous drinking and hypnotic consumption in Western countries. Medical students have been identified at risk for hazardous drinking yet we lacked of national data on their hypnotic consumption and associated factors to guide public health policies. To determine the prevalence of hazardous drinking and dependence among French medical students and their association with psychotropic drug consumption and psychosocial factors. Medical students were recruited from 35 French universities of medicine through administration mailing lists and social networks, be...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 9, 2020 Category: Neuroscience Source Type: research

Quality indicators for mental healthcare in the Danube region: results from a pilot feasibility study
AbstractQuality indicators are vital for monitoring the transformation of institution-based mental health services towards the provision of person-centered mental healthcare. While several mental healthcare quality indicators have been identified as relevant and valid, their actual usability and utility for routine monitoring healthcare quality over time is significantly determined by the availability and trustworthiness of the underlying data. In this feasibility study, quality indicators that have been systematically identified for use in the Danube region countries of Bulgaria, the Czech Republic, Hungary, and Serbia we...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 8, 2020 Category: Neuroscience Source Type: research

AgNOR parameters of dorsal raphe nucleus neurons as a potential diagnostic tool which could aid the differentiation between suicidal and non-suicidal death
(Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - April 7, 2020 Category: Neuroscience Source Type: research

A 2-year longitudinal study of neuropsychological functioning, psychosocial adjustment and rehospitalisation in schizophrenia and major depression.
Authors: Annette S, Stephan G, Mueser KT, Martin H, Elisabeth R, Ulrich G, Marketa C, Rolf E, Hans-Jürgen M, Peter F Abstract Neuropsychological functioning turns out to be a rate-limiting factor in psychiatry. However, little is known when comparing neuropsychological and psychosocial functioning in inpatients with schizophrenia or severe depression in their treatment pathways including add-on psychoeducation or the latter combined with cognitive behavioral therapy up to 2-year follow-up. To evaluate this question, we investigated these variables in two randomised controlled trials including 196 patients with...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 5, 2020 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research