Linking social motivation, general motivation, and social cognition to interpersonal functioning in schizophrenia: insights from exploratory graph analysis
Eur Arch Psychiatry Clin Neurosci. 2023 Dec 19. doi: 10.1007/s00406-023-01733-4. Online ahead of print.ABSTRACTMotivation in general, and social motivation in particular are important for interpersonal functioning in individuals with schizophrenia. Still, their roles after accounting for social cognition, are not well understood. The sample consisted of 147 patients with schizophrenia. General motivation was measured using the Behavioral inhibition/activation scale (BIS/BAS). Social motivation was measured by Passive social withdrawal and Active social avoidance items from PANSS. Interpersonal functioning was evaluated wit...
Source: European Archives of Psychiatry and Clinical Neuroscience - December 19, 2023 Category: Psychiatry Authors: Michal Hajd úk Samuel J Abplanalp Amy M Jimenez Melissa Fisher Kristen M Haut Christine I Hooker Hyunkyu Lee Joseph Ventura Mor Nahum Michael F Green Source Type: research

Improving outcome of treatment-resistant schizophrenia: effects of cognitive remediation therapy
Eur Arch Psychiatry Clin Neurosci. 2023 Dec 19. doi: 10.1007/s00406-023-01731-6. Online ahead of print.ABSTRACTTreatment-Resistant Schizophrenia (TRS) represents a main clinical issue, associated with worse psychopathological outcomes, a more disrupted neurobiological substrate, and poorer neurocognitive performance across several domains, especially in verbal abilities. If cognitive impairment is a major determinant of patients' functional outcomes and quality of life, targeting cognitive dysfunction becomes even more crucial in TRS patients in order to minimize cognitive and functional deterioration. However, although Co...
Source: European Archives of Psychiatry and Clinical Neuroscience - December 19, 2023 Category: Psychiatry Authors: Francesca Martini Marco Spangaro Margherita Bechi Giulia Agostoni Mariachiara Buonocore Jacopo Sapienza Daniela Nocera Chiara Ave Federica Cocchi Roberto Cavallaro Marta Bosia Source Type: research

Linking social motivation, general motivation, and social cognition to interpersonal functioning in schizophrenia: insights from exploratory graph analysis
Eur Arch Psychiatry Clin Neurosci. 2023 Dec 19. doi: 10.1007/s00406-023-01733-4. Online ahead of print.ABSTRACTMotivation in general, and social motivation in particular are important for interpersonal functioning in individuals with schizophrenia. Still, their roles after accounting for social cognition, are not well understood. The sample consisted of 147 patients with schizophrenia. General motivation was measured using the Behavioral inhibition/activation scale (BIS/BAS). Social motivation was measured by Passive social withdrawal and Active social avoidance items from PANSS. Interpersonal functioning was evaluated wit...
Source: European Archives of Psychiatry and Clinical Neuroscience - December 19, 2023 Category: Psychiatry Authors: Michal Hajd úk Samuel J Abplanalp Amy M Jimenez Melissa Fisher Kristen M Haut Christine I Hooker Hyunkyu Lee Joseph Ventura Mor Nahum Michael F Green Source Type: research

Improving outcome of treatment-resistant schizophrenia: effects of cognitive remediation therapy
AbstractTreatment-Resistant Schizophrenia (TRS) represents a main clinical issue, associated with worse psychopathological outcomes, a more disrupted neurobiological substrate, and poorer neurocognitive performance across several domains, especially in verbal abilities. If cognitive impairment is a major determinant of patients ’ functional outcomes and quality of life, targeting cognitive dysfunction becomes even more crucial in TRS patients in order to minimize cognitive and functional deterioration. However, although Cognitive Remediation Therapy (CRT) represents the best available tool to treat cognitive dysfunction ...
Source: European Archives of Psychiatry and Clinical Neuroscience - December 19, 2023 Category: Neuroscience Source Type: research

Linking social motivation, general motivation, and social cognition to interpersonal functioning in schizophrenia: insights from exploratory graph analysis
AbstractMotivation in general, and social motivation in particular are important for interpersonal functioning in individuals with schizophrenia. Still, their roles after accounting for social cognition, are not well understood. The sample consisted of 147 patients with schizophrenia. General motivation was measured using the Behavioral inhibition/activation scale (BIS/BAS). Social motivation was measured by Passive social withdrawal and Active social avoidance items from PANSS. Interpersonal functioning was evaluated with Birchwood ’s Social Functioning Scale (SFS). We used Exploratory Graph Analysis for network estimat...
Source: European Archives of Psychiatry and Clinical Neuroscience - December 19, 2023 Category: Neuroscience Source Type: research

Improving outcome of treatment-resistant schizophrenia: effects of cognitive remediation therapy
AbstractTreatment-Resistant Schizophrenia (TRS) represents a main clinical issue, associated with worse psychopathological outcomes, a more disrupted neurobiological substrate, and poorer neurocognitive performance across several domains, especially in verbal abilities. If cognitive impairment is a major determinant of patients ’ functional outcomes and quality of life, targeting cognitive dysfunction becomes even more crucial in TRS patients in order to minimize cognitive and functional deterioration. However, although Cognitive Remediation Therapy (CRT) represents the best available tool to treat cognitive dysfunction ...
Source: European Archives of Psychiatry and Clinical Neuroscience - December 19, 2023 Category: Neuroscience Source Type: research

Linking social motivation, general motivation, and social cognition to interpersonal functioning in schizophrenia: insights from exploratory graph analysis
AbstractMotivation in general, and social motivation in particular are important for interpersonal functioning in individuals with schizophrenia. Still, their roles after accounting for social cognition, are not well understood. The sample consisted of 147 patients with schizophrenia. General motivation was measured using the Behavioral inhibition/activation scale (BIS/BAS). Social motivation was measured by Passive social withdrawal and Active social avoidance items from PANSS. Interpersonal functioning was evaluated with Birchwood ’s Social Functioning Scale (SFS). We used Exploratory Graph Analysis for network estimat...
Source: European Archives of Psychiatry and Clinical Neuroscience - December 19, 2023 Category: Neuroscience Source Type: research

The correlation of Esketamine with specific adverse events: a deep dive into the FAERS database
This study underscores the potential adverse reactions and risks of Esketamine in clinical applications, especially regarding long-term efficacy, addiction risks, and suicidal risks.PMID:38103077 | DOI:10.1007/s00406-023-01732-5 (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - December 16, 2023 Category: Psychiatry Authors: Ying Jiang Zhiqiang Du Yuan Shen Qin Zhou Haohao Zhu Source Type: research

The correlation of Esketamine with specific adverse events: a deep dive into the FAERS database
This study underscores the potential adverse reactions and risks of Esketamine in clinical applications, especially regarding long-term efficacy, addiction risks, and suicidal risks. (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - December 16, 2023 Category: Neuroscience Source Type: research

LD block disorder-specific pleiotropic roles of novel CRHR1 in type 2 diabetes and depression disorder comorbidity
AbstractMajor depressive disorder (MDD) and type 2 diabetes (T2D) are complex disorders whose comorbidity can be due to hypercortisolism and may be explained by dysfunction of the corticotropin-releasing hormone receptor 1 (CRHR1) and cortisol feedback within the hypothalamic –pituitary–adrenal axis (HPA axis). To investigate the role of theCRHR1 gene in familial T2D, MDD, and MDD-T2D comorbidity, we tested 152 CRHR1 single-nucleotide-polymorphisms (SNPs), via 2-point parametric linkage and linkage disequilibrium (LD; i.e., association) analyses using 4 models, in 212 peninsular families with T2D and MDD. We detected l...
Source: European Archives of Psychiatry and Clinical Neuroscience - December 14, 2023 Category: Neuroscience Source Type: research

Deconstructing depression by machine learning: the POKAL-PSY study
Eur Arch Psychiatry Clin Neurosci. 2023 Dec 13. doi: 10.1007/s00406-023-01720-9. Online ahead of print.ABSTRACTUnipolar depression is a prevalent and disabling condition, often left untreated. In the outpatient setting, general practitioners fail to recognize depression in about 50% of cases mainly due to somatic comorbidities. Given the significant economic, social, and interpersonal impact of depression and its increasing prevalence, there is a need to improve its diagnosis and treatment in outpatient care. Various efforts have been made to isolate individual biological markers for depression to streamline diagnostic and...
Source: European Archives of Psychiatry and Clinical Neuroscience - December 13, 2023 Category: Psychiatry Authors: Julia Eder Lisa Pfeiffer Sven P Wichert Benjamin Keeser Maria S Simon David Popovic Catherine Glocker Andre R Brunoni Antonius Schneider Jochen Gensichen Andrea Schmitt Richard Musil Peter Falkai POKAL Group Source Type: research