Validity and clinical utility of the DSM-5 severity specifier for bulimia nervosa: results from a multisite sample of patients who received evidence-based treatment.
Authors: Dakanalis A, Bartoli F, Caslini M, Crocamo C, Zanetti MA, Riva G, Clerici M, Carrà G Abstract A new "severity specifier" for bulimia nervosa (BN), based on the frequency of inappropriate weight compensatory behaviours (IWCBs), was added to the DSM-5 as a means of documenting heterogeneity and variability in the severity of the disorder. Yet, evidence for its validity in clinical populations, including prognostic significance for treatment outcome, is currently lacking. Existing data from 281 treatment-seeking patients with DSM-5 BN, who received the best available treatment for their disor...
Source: European Archives of Psychiatry and Clinical Neuroscience - July 21, 2016 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Instability of visual error processing for sensorimotor adaptation in schizophrenia
Abstract Saccadic adaptation can be used to study disturbances of sensory processing and motor learning. We investigated whether patients with schizophrenia can adjust saccadic amplitudes to account for an increase in visual error while the saccade is in flight, and whether they transfer this change to a visuo-manual localization task. Fourteen patients (mean 37.1  years) and 14 healthy controls (mean 35.1 years) performed 200 adaptation trials of 10° with target shifts of 4° in the outward direction. We determined the percent amplitude change during adaptation and adaptation speed. In addition, subjects...
Source: European Archives of Psychiatry and Clinical Neuroscience - July 21, 2016 Category: Neuroscience Source Type: research

Network meta-analyses should be the highest level of evidence in treatment guidelines
(Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - July 19, 2016 Category: Neuroscience Source Type: research

Validity and clinical utility of the DSM-5 severity specifier for bulimia nervosa: results from a multisite sample of patients who received evidence-based treatment
Abstract A new “severity specifier” for bulimia nervosa (BN), based on the frequency of inappropriate weight compensatory behaviours (IWCBs), was added to the DSM-5 as a means of documenting heterogeneity and variability in the severity of the disorder. Yet, evidence for its validity in clinical populations, including prognostic significance for treatment outcome, is currently lacking. Existing data from 281 treatment-seeking patients with DSM-5 BN, who received the best available treatment for their disorder (manual-based cognitive behavioural therapy; CBT) in an outpatient setting, were re-analysed t...
Source: European Archives of Psychiatry and Clinical Neuroscience - July 19, 2016 Category: Neuroscience Source Type: research

Stepping up: the just released new impact factor 2015
(Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - July 18, 2016 Category: Neuroscience Source Type: research

Neurocognitive performance, subjective well-being, and psychosocial functioning after benzodiazepine withdrawal in patients with schizophrenia or bipolar disorder: a randomized clinical trial of add-on melatonin versus placebo.
In conclusion, add-on melatonin does not seem to affect cognition, well-being, or psychosocial functioning in patients with severe mental illness. The observed improvement in cognitive performance could not be distinguished from retest effects, which may in turn have been facilitated by the benzodiazepine tapering. PMID: 27400927 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - July 14, 2016 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Neurocognitive performance, subjective well-being, and psychosocial functioning after benzodiazepine withdrawal in patients with schizophrenia or bipolar disorder: a randomized clinical trial of add-on melatonin versus placebo
In conclusion, add-on melatonin does not seem to affect cognition, well-being, or psychosocial functioning in patients with severe mental illness. The observed improvement in cognitive performance could not be distinguished from retest effects, which may in turn have been facilitated by the benzodiazepine tapering. (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - July 11, 2016 Category: Neuroscience Source Type: research

The relationships of personal resources with symptom severity and psychosocial functioning in persons with schizophrenia: results from the Italian Network for Research on Psychoses study.
Authors: Rossi A, Galderisi S, Rocca P, Bertolino A, Mucci A, Rucci P, Gibertoni D, Aguglia E, Amore M, Andriola I, Bellomo A, Biondi M, Callista G, Comparelli A, Dell'Osso L, Di Giannantonio M, Fagiolini A, Marchesi C, Monteleone P, Montemagni C, Niolu C, Piegari G, Pinna F, Roncone R, Stratta P, Tenconi E, Vita A, Zeppegno P, Maj M, Italian Network for Research on Psychoses Abstract The relationships of personal resources with symptom severity and psychosocial functioning have never been tested systematically in a large sample of people with schizophrenia. We applied structural equation models to a sample of 921 ...
Source: European Archives of Psychiatry and Clinical Neuroscience - July 8, 2016 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Psychiatric disorders biochemical pathways unraveled by human brain proteomics.
Authors: Saia-Cereda VM, Cassoli JS, Martins-de-Souza D, Nascimento JM Abstract Approximately 25 % of the world population is affected by a mental disorder at some point in their life. Yet, only in the mid-twentieth century a biological cause has been proposed for these diseases. Since then, several studies have been conducted toward a better comprehension of those disorders, and although a strong genetic influence was revealed, the role of these genes in disease mechanism is still unclear. This led most recent studies to focus on the molecular basis of mental disorders. One line of investigation that has rise...
Source: European Archives of Psychiatry and Clinical Neuroscience - July 7, 2016 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

The relationships of personal resources with symptom severity and psychosocial functioning in persons with schizophrenia: results from the Italian Network for Research on Psychoses study
Abstract The relationships of personal resources with symptom severity and psychosocial functioning have never been tested systematically in a large sample of people with schizophrenia. We applied structural equation models to a sample of 921 patients with schizophrenia collected in a nationwide Italian study, with the aim to identify, among a large set of personal resources, those that may have an association with symptom severity or psychosocial functioning. Several relevant demographic and clinical variables were considered concurrently. Poor service engagement and poor recovery style, as well as older age and ...
Source: European Archives of Psychiatry and Clinical Neuroscience - July 6, 2016 Category: Neuroscience Source Type: research

Problem solving, impulse control and planning in patients with early- and late-stage Huntington's disease.
Authors: Mörkl S, Müller NJ, Blesl C, Wilkinson L, Tmava A, Wurm W, Holl AK, Painold A Abstract Sub-domains of executive functions, including problems with planning, accuracy, impulsivity, and inhibition, are core features of Huntington's disease. It is known that the decline of cognitive function in Huntington's disease is related to the anatomical progression of pathology in the basal ganglia. However, it remains to be determined whether the severity of executive dysfunction depends on the stage of the disease. To examine the severity of sub-domains of executive dysfunction in early- and late-stage Hunt...
Source: European Archives of Psychiatry and Clinical Neuroscience - July 5, 2016 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Psychiatric disorders biochemical pathways unraveled by human brain proteomics
Abstract Approximately 25 % of the world population is affected by a mental disorder at some point in their life. Yet, only in the mid-twentieth century a biological cause has been proposed for these diseases. Since then, several studies have been conducted toward a better comprehension of those disorders, and although a strong genetic influence was revealed, the role of these genes in disease mechanism is still unclear. This led most recent studies to focus on the molecular basis of mental disorders. One line of investigation that has risen in the post-genomic era is proteomics, due to its power of revealing...
Source: European Archives of Psychiatry and Clinical Neuroscience - July 4, 2016 Category: Neuroscience Source Type: research

Problem solving, impulse control and planning in patients with early- and late-stage Huntington ’s disease
Abstract Sub-domains of executive functions, including problems with planning, accuracy, impulsivity, and inhibition, are core features of Huntington ’s disease. It is known that the decline of cognitive function in Huntington’s disease is related to the anatomical progression of pathology in the basal ganglia. However, it remains to be determined whether the severity of executive dysfunction depends on the stage of the disease. To examine th e severity of sub-domains of executive dysfunction in early- and late-stage Huntington’s disease, we studied performance in the Tower of London task of two groups o...
Source: European Archives of Psychiatry and Clinical Neuroscience - July 2, 2016 Category: Neuroscience Source Type: research

Problem solving, impulse control and planning in patients with early- and late-stage Huntington’s disease
Abstract Sub-domains of executive functions, including problems with planning, accuracy, impulsivity, and inhibition, are core features of Huntington’s disease. It is known that the decline of cognitive function in Huntington’s disease is related to the anatomical progression of pathology in the basal ganglia. However, it remains to be determined whether the severity of executive dysfunction depends on the stage of the disease. To examine the severity of sub-domains of executive dysfunction in early- and late-stage Huntington’s disease, we studied performance in the Tower of London task of two g...
Source: European Archives of Psychiatry and Clinical Neuroscience - July 2, 2016 Category: Neuroscience Source Type: research

Birth by cesarean section and schizophrenia: results from the multicenter FACE-SZ data-set.
Authors: Fond G, Bulzacka E, Boyer L, Llorca PM, Godin O, Brunel L, Andrianarisoa MG, Aouizerate B, Berna F, Capdevielle D, Chereau I, Denizot H, Dorey JM, Dubertret C, Dubreucq J, Faget C, Gabayet F, Le Strat Y, Micoulaud-Franchi JA, Misdrahi D, Rey R, Richieri R, Roger M, Passerieux C, Schandrin A, Urbach M, Vidalhet P, Schürhoff F, Leboyer M, FondaMental Academic Centers of Expertise for Schizophrenia (FACE-SZ) Group Abstract Children born by cesarean section ("c-birth") are known to have different microbiota and a natural history of different disorders including allergy, asthma and overweight com...
Source: European Archives of Psychiatry and Clinical Neuroscience - July 1, 2016 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Birth by cesarean section and schizophrenia: results from the multicenter FACE-SZ data-set
Abstract Children born by cesarean section (“c-birth”) are known to have different microbiota and a natural history of different disorders including allergy, asthma and overweight compared to vaginally born (“v-birth”) children. C-birth is not known to increase the risk of schizophrenia (SZ), but to be associated with an earlier age at onset. To further explore possible links between c-birth and SZ, we compared clinical and biological characteristics of c-born SZ patients compared to v-born ones. Four hundred and fifty-four stable community-dwelling SZ patients (mean age = 32....
Source: European Archives of Psychiatry and Clinical Neuroscience - June 27, 2016 Category: Neuroscience Source Type: research

Efficacy and tolerability of Z-drug adjunction to antidepressant treatment for major depressive disorder: a systematic review and meta-analysis of randomized controlled trials.
In conclusion, Z-drugs + antidepressants improves the treatment efficacy for MDD compared with the placebo + antidepressants/antidepressants alone. However, the therapy requires close monitoring of adverse events, particularly dizziness. PMID: 27318835 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - June 20, 2016 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Efficacy and tolerability of Z-drug adjunction to antidepressant treatment for major depressive disorder: a systematic review and meta-analysis of randomized controlled trials
In conclusion, Z-drugs + antidepressants improves the treatment efficacy for MDD compared with the placebo + antidepressants/antidepressants alone. However, the therapy requires close monitoring of adverse events, particularly dizziness. (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - June 18, 2016 Category: Neuroscience Source Type: research

Restricted attention to social cues in schizophrenia patients.
Authors: Nikolaides A, Miess S, Auvera I, Müller R, Klosterkötter J, Ruhrmann S Abstract Deficits of psychosocial functioning are a robust finding in schizophrenia. Research on social cognition may open a new avenue for the development of effective interventions. As a correlate of social perceptive information processing deficits, schizophrenia patients (SZP) show deviant gaze behavior (GB) while viewing emotional faces. As understanding of a social environment requires gathering complex social information, our study aimed at investigating the gaze behavior of SZP related to social interactions and its im...
Source: European Archives of Psychiatry and Clinical Neuroscience - June 17, 2016 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Restricted attention to social cues in schizophrenia patients
Abstract Deficits of psychosocial functioning are a robust finding in schizophrenia. Research on social cognition may open a new avenue for the development of effective interventions. As a correlate of social perceptive information processing deficits, schizophrenia patients (SZP) show deviant gaze behavior (GB) while viewing emotional faces. As understanding of a social environment requires gathering complex social information, our study aimed at investigating the gaze behavior of SZP related to social interactions and its impact on the level of social and role functioning. GB of 32 SZP and 37 healthy control ind...
Source: European Archives of Psychiatry and Clinical Neuroscience - June 15, 2016 Category: Neuroscience Source Type: research

The 5-HTTLPR and BDNF polymorphisms moderate the association between uncinate fasciculus connectivity and antidepressants treatment response in major depression.
Authors: Tatham EL, Hall GB, Clark D, Foster J, Ramasubbu R Abstract Symptom improvement in depression due to antidepressant treatment is highly variable and clinically unpredictable. Linking neuronal connectivity and genetic risk factors in predicting antidepressant response has clinical implications. Our investigation assessed whether indices of white matter integrity, serotonin transporter-linked polymorphism (5-HTTLPR) and brain-derived neurotrophic factor (BDNF) val66met polymorphism predicted magnitude of depression symptom change following antidepressant treatment. Fractional anisotropy (FA) was used as an i...
Source: European Archives of Psychiatry and Clinical Neuroscience - June 11, 2016 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Using the cognitive assessment interview to screen cognitive impairment in psychosis.
This study examines the validity of the CAI (adapted to Spanish, CAI-Sp) as a screening instrument for cognitive impairment, compared to an objective test of cognitive functioning. The psychometric properties of the CAI-Sp and its association with clinical dimensions are also explored. Eighty-one patients with a psychotic disorder and 38 healthy controls were assessed using the CAI-Sp and the screen for cognitive impairment in psychiatry (SCIP-S). Patients also underwent a clinical assessment. Poorer cognitive functioning as assessed with the CAI-Sp was associated to illness severity, specifically positive, negative and di...
Source: European Archives of Psychiatry and Clinical Neuroscience - June 10, 2016 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

The 5-HTTLPR and BDNF polymorphisms moderate the association between uncinate fasciculus connectivity and antidepressants treatment response in major depression
Abstract Symptom improvement in depression due to antidepressant treatment is highly variable and clinically unpredictable. Linking neuronal connectivity and genetic risk factors in predicting antidepressant response has clinical implications. Our investigation assessed whether indices of white matter integrity, serotonin transporter-linked polymorphism (5-HTTLPR) and brain-derived neurotrophic factor (BDNF) val66met polymorphism predicted magnitude of depression symptom change following antidepressant treatment. Fractional anisotropy (FA) was used as an indicator of white matter integrity and was assessed in the...
Source: European Archives of Psychiatry and Clinical Neuroscience - June 8, 2016 Category: Neuroscience Source Type: research

mTOR inhibitor reverses autistic-like social deficit behaviours in adult rats with both Tsc2 haploinsufficiency and developmental status epilepticus.
Authors: Schneider M, de Vries PJ, Schönig K, Rößner V, Waltereit R Abstract Epilepsy is a major risk factor for autism spectrum disorder (ASD) and complicates clinical manifestations and management of ASD significantly. Tuberous sclerosis complex (TSC), caused by TSC1 or TSC2 mutations, is one of the medical conditions most commonly associated with ASD and has become an important model to examine molecular pathways associated with ASD. Previous research showed reversal of autism-like social deficits in Tsc1 (+/-) and Tsc2 (+/-) mouse models by mammalian target of rapamycin (mTOR) inhibitors. Howeve...
Source: European Archives of Psychiatry and Clinical Neuroscience - June 7, 2016 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Using the cognitive assessment interview to screen cognitive impairment in psychosis
This study examines the validity of the CAI (adapted to Spanish, CAI-Sp) as a screening instrument for cognitive impairment, compared to an objective test of cognitive functioning. The psychometric properties of the CAI-Sp and its association with clinical dimensions are also explored. Eighty-one patients with a psychotic disorder and 38 healthy controls were assessed using the CAI-Sp and the screen for cognitive impairment in psychiatry (SCIP-S). Patients also underwent a clinical assessment. Poorer cognitive functioning as assessed with the CAI-Sp was associated to illness severity, specifically positive, negative and di...
Source: European Archives of Psychiatry and Clinical Neuroscience - June 6, 2016 Category: Neuroscience Source Type: research

Comments on "Altered lipid peroxidation markers are related to post-traumatic stress disorder (PTSD) and not trauma itself in earthquake survivors".
Comments on "Altered lipid peroxidation markers are related to post-traumatic stress disorder (PTSD) and not trauma itself in earthquake survivors". Eur Arch Psychiatry Clin Neurosci. 2016 Jun 2; Authors: Khoubnasabjafari M, Jouyban A PMID: 27255143 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - June 5, 2016 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

General and social cognition in remitted first-episode schizophrenia patients: a comparative study.
Authors: Caldiroli A, Buoli M, Serati M, Cahn W, Altamura AC Abstract The aim of this paper was to investigate whether both neurocognitive and social cognitive performances were different between remitted first-episode schizophrenia patients, non-remitters and healthy controls (HC). We assessed social cognition (Degraded Facial Affect Recognition Task-DFAR and Emotional Mentalizing Task-EMT) and neurocognition (Wechsler Adult Intelligence Scale and Word Learning Test-WLT) in 174 remitted first-episode schizophrenia patients, 110 non-remitted first-episode schizophrenia patients and 320 HC. Multivariate analyses of ...
Source: European Archives of Psychiatry and Clinical Neuroscience - June 4, 2016 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

mTOR inhibitor reverses autistic-like social deficit behaviours in adult rats with both Tsc2 haploinsufficiency and developmental status epilepticus
Abstract Epilepsy is a major risk factor for autism spectrum disorder (ASD) and complicates clinical manifestations and management of ASD significantly. Tuberous sclerosis complex (TSC), caused by TSC1 or TSC2 mutations, is one of the medical conditions most commonly associated with ASD and has become an important model to examine molecular pathways associated with ASD. Previous research showed reversal of autism-like social deficits in Tsc1 +/− and Tsc2 +/− mouse models by mammalian target of rapamycin (mTOR) inhibitors. However, at least 70 % of individuals with TSC a...
Source: European Archives of Psychiatry and Clinical Neuroscience - June 4, 2016 Category: Neuroscience Source Type: research

Comments on “Altered lipid peroxidation markers are related to post-traumatic stress disorder (PTSD) and not trauma itself in earthquake survivors”
(Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - June 2, 2016 Category: Neuroscience Source Type: research

General and social cognition in remitted first-episode schizophrenia patients: a comparative study
Abstract The aim of this paper was to investigate whether both neurocognitive and social cognitive performances were different between remitted first-episode schizophrenia patients, non-remitters and healthy controls (HC). We assessed social cognition (Degraded Facial Affect Recognition Task—DFAR and Emotional Mentalizing Task—EMT) and neurocognition (Wechsler Adult Intelligence Scale and Word Learning Test—WLT) in 174 remitted first-episode schizophrenia patients, 110 non-remitted first-episode schizophrenia patients and 320 HC. Multivariate analyses of variance with age, gender and IQ as covar...
Source: European Archives of Psychiatry and Clinical Neuroscience - June 1, 2016 Category: Neuroscience Source Type: research

Neuroscience-based nomenclature (jNbN) to replace traditional terminology of psychotropic medications.
Authors: Möller HJ, Schmitt A, Falkai P PMID: 27216433 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - May 26, 2016 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Neuroscience-based nomenclature (jNbN) to replace traditional terminology of psychotropic medications
(Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - May 23, 2016 Category: Neuroscience Source Type: research

The customer is always right? Subjective target symptoms and treatment preferences in patients with psychosis.
Authors: Moritz S, Berna F, Jaeger S, Westermann S, Nagel M Abstract Clinicians and patients differ concerning the goals of treatment. Eighty individuals with schizophrenia were assessed online about which symptoms they consider the most important for treatment, as well as their experience with different interventions. Treatment of affective and neuropsychological problems was judged as more important than treatment of positive symptoms (p 
Source: European Archives of Psychiatry and Clinical Neuroscience - May 21, 2016 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

The customer is always right? Subjective target symptoms and treatment preferences in patients with psychosis
Abstract Clinicians and patients differ concerning the goals of treatment. Eighty individuals with schizophrenia were assessed online about which symptoms they consider the most important for treatment, as well as their experience with different interventions. Treatment of affective and neuropsychological problems was judged as more important than treatment of positive symptoms (p 
Source: European Archives of Psychiatry and Clinical Neuroscience - May 18, 2016 Category: Neuroscience Source Type: research

Self-stigma and suicidality: a longitudinal study.
Authors: Oexle N, Rüsch N, Viering S, Wyss C, Seifritz E, Xu Z, Kawohl W Abstract Mental illness stigma is a source of distress for persons with mental illness. Self-stigma occurs when negative stereotypes are internalized, leading to low self-esteem, shame and hopelessness. Due to its consequences self-stigma may contribute to suicidality and be a modifiable target for suicide prevention. Based on 222 disability pensioners with mental illness we examined whether self-stigma at baseline is associated with suicidal ideation over a 2-year period, controlling for baseline suicidal ideation, symptoms, age and gend...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 15, 2016 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Self-stigma and suicidality: a longitudinal study
Abstract Mental illness stigma is a source of distress for persons with mental illness. Self-stigma occurs when negative stereotypes are internalized, leading to low self-esteem, shame and hopelessness. Due to its consequences self-stigma may contribute to suicidality and be a modifiable target for suicide prevention. Based on 222 disability pensioners with mental illness we examined whether self-stigma at baseline is associated with suicidal ideation over a 2-year period, controlling for baseline suicidal ideation, symptoms, age and gender. More self-stigma predicted suicidal ideation at baseline and longitudinal...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 12, 2016 Category: Neuroscience Source Type: research

Negative symptoms and their association with depressive symptoms in the long-term course of schizophrenia.
Authors: An der Heiden W, Leber A, Häfner H Abstract Depressive symptoms abound in schizophrenia and even in subclinical states of the disorder. We studied the frequency of these symptoms and their relationship to negative symptoms from the first psychotic episode on over a long-term course of 134 months on data for 107 patients in our ABC Schizophrenia Study. Prevalence rates of 90 % for presenting at least one negative symptom and of 60 % for presenting at least one depressive symptom in the first psychotic episode illustrate the frequency of these syndromes. After the remission of psychosis t...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 26, 2016 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Negative symptoms and their association with depressive symptoms in the long-term course of schizophrenia
Abstract Depressive symptoms abound in schizophrenia and even in subclinical states of the disorder. We studied the frequency of these symptoms and their relationship to negative symptoms from the first psychotic episode on over a long-term course of 134 months on data for 107 patients in our ABC Schizophrenia Study. Prevalence rates of 90 % for presenting at least one negative symptom and of 60 % for presenting at least one depressive symptom in the first psychotic episode illustrate the frequency of these syndromes. After the remission of psychosis the rates fell to 50 % (negative symptoms) a...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 23, 2016 Category: Neuroscience Source Type: research

Neural correlates of distraction in borderline personality disorder before and after dialectical behavior therapy.
In conclusion, our findings reveal changes in neural activity associated with distraction during emotion processing after DBT in patients with BPD. These changes point to lower emotional susceptibility during distraction after BPD symptom improvement. PMID: 27091455 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - April 21, 2016 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Reduction of dopamine D2/3 receptor binding in the striatum after a single administration of esketamine, but not R-ketamine: a PET study in conscious monkeys.
This study suggests that unlike to R-ketamine, esketamine can cause dopamine release in the striatum, and that its release might be associated with psychotomimetic effects of esketamine. PMID: 27091456 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - April 21, 2016 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Erratum to: Stress, burnout, and job dissatisfaction in mental health workers.
Authors: Rössler W PMID: 27094190 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - April 21, 2016 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Erratum to: EPA guidance on improving the image of psychiatry.
Authors: Möller-Leimkühler AM, Möller HJ, Maier W, Gaebel W, Falkai P PMID: 27094191 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - April 21, 2016 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Regional differences in the expression of brain-derived neurotrophic factor (BDNF) pro-peptide, proBDNF and preproBDNF in the brain confer stress resilience.
This study suggests that regional differences in conversion of BDNF precursors into BDNF and BDNF pro-peptide by proteolytic cleavage may contribute to stress resilience. PMID: 27094192 [PubMed - as supplied by publisher] (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - April 21, 2016 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Two-week neurasthenic major depression.
This study defines major depressive episodes according to DSM-5 and neurasthenia by ICD-10 symptom criteria, and both syndromes on the basis of a 2-week minimum duration. The study includes all subjects of the Zurich epidemiological study who had taken part in the last five interviews (1986-2008) and compares three groups, pure depression, pure neurasthenia and their combination (neurasthenic depression), applying nonparametric statistics. The three groups did not differ in common validators: age of onset, course, a family history for depression and anxiety/panic. Psychiatric comorbidity was also very similar, with the exc...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 21, 2016 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Two-week neurasthenic major depression
This study defines major depressive episodes according to DSM-5 and neurasthenia by ICD-10 symptom criteria, and both syndromes on the basis of a 2-week minimum duration. The study includes all subjects of the Zurich epidemiological study who had taken part in the last five interviews (1986–2008) and compares three groups, pure depression, pure neurasthenia and their combination (neurasthenic depression), applying nonparametric statistics. The three groups did not differ in common validators: age of onset, course, a family history for depression and anxiety/panic. Psychiatric comorbidity was also very similar, with t...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 19, 2016 Category: Neuroscience Source Type: research

Regional differences in the expression of brain-derived neurotrophic factor (BDNF) pro-peptide, proBDNF and preproBDNF in the brain confer stress resilience
This study suggests that regional differences in conversion of BDNF precursors into BDNF and BDNF pro-peptide by proteolytic cleavage may contribute to stress resilience. (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - April 19, 2016 Category: Neuroscience Source Type: research

Erratum to: Stress, burnout, and job dissatisfaction in mental health workers
(Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - April 19, 2016 Category: Neuroscience Source Type: research

Erratum to: EPA guidance on improving the image of psychiatry
(Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - April 19, 2016 Category: Neuroscience Source Type: research

Expressional profile of the diacylglycerol kinase eta gene DGKH.
Authors: Weißflog L, Becker N, Bossert N, Freudenberg F, Kittel-Schneider S, Reif A Abstract Bipolar disorder (BPD) is a genetically complex mental disorder, which is characterized by recurrent depressive and manic episodes, occurring with a typical cyclical course. In a recent study, we were able to identify a risk haplotype for BPD, as well as for unipolar depression and adult attention-deficit/hyperactivity disorder (ADHD), within the DGKH gene. DGKH codes for the eta (η) isoform of diacylglycerol kinase, which is involved in the phosphoinositol pathway. In the present study, we determined the expressi...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 18, 2016 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Reduction of dopamine D 2/3 receptor binding in the striatum after a single administration of esketamine, but not R-ketamine: a PET study in conscious monkeys
This study suggests that unlike to R-ketamine, esketamine can cause dopamine release in the striatum, and that its release might be associated with psychotomimetic effects of esketamine. (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - April 18, 2016 Category: Neuroscience Source Type: research