Prevalence and associated factors of obesity in patients with major depressive disorder at different ages of onset
This study totally recruited 1718 first-episode drug-naive MDD patients aged from 18 to 60  years. All subjects were divided into two subgroups: early adulthood onset (EAO, 18–45 years) and mid-adulthood onset (MAO, 45–60 years). Clinical symptoms of patients were evaluated using the 17-item Hamilton Depression Rating Scale (HAMD-17), Hamilton Anxiety Scale (HAMA), and Positive and Negative Syndrome Scale (PANSS) positive subscale. Baseline parameters including body mass index (BMI), blood pressure, and hematological biochemical parameters were assessed to investigate the association between these parameters and wei...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 15, 2024 Category: Neuroscience Source Type: research

The curious absence of psychosis in GRIN1-related neurodevelopmental disorder
Eur Arch Psychiatry Clin Neurosci. 2024 Mar 14. doi: 10.1007/s00406-024-01796-x. Online ahead of print.NO ABSTRACTPMID:38483682 | DOI:10.1007/s00406-024-01796-x (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - March 14, 2024 Category: Psychiatry Authors: Mark A Colijn Robert M Stowe Source Type: research

The curious absence of psychosis in GRIN1-related neurodevelopmental disorder
(Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - March 14, 2024 Category: Neuroscience Source Type: research

Borderline personality disorder vs. schizophrenia spectrum disorders in young people recruited within an "Early Intervention in Psychosis" service: clinical and outcome comparisons
Eur Arch Psychiatry Clin Neurosci. 2024 Mar 12. doi: 10.1007/s00406-024-01772-5. Online ahead of print.ABSTRACTBorderline Personality Disorder (BPD) is under-recognized in First-Episode Psychosis (FEP) and its psychotic manifestations are difficult to differentiate from Schizophrenia Spectrum Disorders (SSD). The aim of this investigation was to compare clinical, sociodemographic, and outcome characteristics between FEP patients with BPD vs. FEP subjects with SSD both at baseline and across a 2-year follow-up period. Participants completed the Health of the Nation Outcome Scale (HoNOS), the Positive And Negative Syndrome S...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 13, 2024 Category: Psychiatry Authors: Lorenzo Pelizza Emanuela Leuci Emanuela Quattrone Silvia Azzali Giuseppina Paulillo Simona Pupo Pietro Pellegrini Lorenzo Gammino Arianna Biancalani Marco Menchetti Source Type: research

Association of empathy with clinical symptoms and cognitive function in chronic schizophrenia patients with and without suicide attempts
Eur Arch Psychiatry Clin Neurosci. 2024 Mar 13. doi: 10.1007/s00406-024-01785-0. Online ahead of print.ABSTRACTCognitive impairment is recognized as a risk factor for suicide in schizophrenia (SZ) patients. Despite empathy being an important aspect of social cognition, the association between suicidal behavior and empathy has received little attention. We aimed to compare empathy and neurocognition in SZ patients with and without suicide attempts (SAs), and to explore the relationship between empathy, neurocognition, and clinical symptoms in SZ patients with and without SAs. Data on SAs and socio-demographic characteristic...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 13, 2024 Category: Psychiatry Authors: Zheng Ma Yang Tian Jiaxin Li Junyao Liu Dong-Mei Wang Xiang-Yang Zhang Source Type: research

The impact of the COVID-19 pandemic on perceptions of social relationships, negative affect, and paranoid ideation
Eur Arch Psychiatry Clin Neurosci. 2024 Mar 13. doi: 10.1007/s00406-024-01777-0. Online ahead of print.ABSTRACTThe COVID-19 pandemic contributed to worsening mental health across the globe. The pandemic may have been especially impactful on those experiencing heightened psychosis spectrum symptomatology given greater pre-pandemic social isolation and increased vulnerability to stress. Yet, few studies exploring the impact of the COVID-19 pandemic on perceptions of social relationships and mental health have sampled individuals high in psychosis spectrum symptomatology, including those with psychosis spectrum disorders. Uti...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 13, 2024 Category: Psychiatry Authors: Ryan D Orth Christina L G Savage Melanie E Bennett Jack J Blanchard Source Type: research

Borderline personality disorder vs. schizophrenia spectrum disorders in young people recruited within an "Early Intervention in Psychosis" service: clinical and outcome comparisons
Eur Arch Psychiatry Clin Neurosci. 2024 Mar 12. doi: 10.1007/s00406-024-01772-5. Online ahead of print.ABSTRACTBorderline Personality Disorder (BPD) is under-recognized in First-Episode Psychosis (FEP) and its psychotic manifestations are difficult to differentiate from Schizophrenia Spectrum Disorders (SSD). The aim of this investigation was to compare clinical, sociodemographic, and outcome characteristics between FEP patients with BPD vs. FEP subjects with SSD both at baseline and across a 2-year follow-up period. Participants completed the Health of the Nation Outcome Scale (HoNOS), the Positive And Negative Syndrome S...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 13, 2024 Category: Psychiatry Authors: Lorenzo Pelizza Emanuela Leuci Emanuela Quattrone Silvia Azzali Giuseppina Paulillo Simona Pupo Pietro Pellegrini Lorenzo Gammino Arianna Biancalani Marco Menchetti Source Type: research

Association of empathy with clinical symptoms and cognitive function in chronic schizophrenia patients with and without suicide attempts
Eur Arch Psychiatry Clin Neurosci. 2024 Mar 13. doi: 10.1007/s00406-024-01785-0. Online ahead of print.ABSTRACTCognitive impairment is recognized as a risk factor for suicide in schizophrenia (SZ) patients. Despite empathy being an important aspect of social cognition, the association between suicidal behavior and empathy has received little attention. We aimed to compare empathy and neurocognition in SZ patients with and without suicide attempts (SAs), and to explore the relationship between empathy, neurocognition, and clinical symptoms in SZ patients with and without SAs. Data on SAs and socio-demographic characteristic...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 13, 2024 Category: Psychiatry Authors: Zheng Ma Yang Tian Jiaxin Li Junyao Liu Dong-Mei Wang Xiang-Yang Zhang Source Type: research

The impact of the COVID-19 pandemic on perceptions of social relationships, negative affect, and paranoid ideation
Eur Arch Psychiatry Clin Neurosci. 2024 Mar 13. doi: 10.1007/s00406-024-01777-0. Online ahead of print.ABSTRACTThe COVID-19 pandemic contributed to worsening mental health across the globe. The pandemic may have been especially impactful on those experiencing heightened psychosis spectrum symptomatology given greater pre-pandemic social isolation and increased vulnerability to stress. Yet, few studies exploring the impact of the COVID-19 pandemic on perceptions of social relationships and mental health have sampled individuals high in psychosis spectrum symptomatology, including those with psychosis spectrum disorders. Uti...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 13, 2024 Category: Psychiatry Authors: Ryan D Orth Christina L G Savage Melanie E Bennett Jack J Blanchard Source Type: research

Borderline personality disorder vs. schizophrenia spectrum disorders in young people recruited within an "Early Intervention in Psychosis" service: clinical and outcome comparisons
Eur Arch Psychiatry Clin Neurosci. 2024 Mar 12. doi: 10.1007/s00406-024-01772-5. Online ahead of print.ABSTRACTBorderline Personality Disorder (BPD) is under-recognized in First-Episode Psychosis (FEP) and its psychotic manifestations are difficult to differentiate from Schizophrenia Spectrum Disorders (SSD). The aim of this investigation was to compare clinical, sociodemographic, and outcome characteristics between FEP patients with BPD vs. FEP subjects with SSD both at baseline and across a 2-year follow-up period. Participants completed the Health of the Nation Outcome Scale (HoNOS), the Positive And Negative Syndrome S...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 13, 2024 Category: Psychiatry Authors: Lorenzo Pelizza Emanuela Leuci Emanuela Quattrone Silvia Azzali Giuseppina Paulillo Simona Pupo Pietro Pellegrini Lorenzo Gammino Arianna Biancalani Marco Menchetti Source Type: research

The impact of the COVID-19 pandemic on perceptions of social relationships, negative affect, and paranoid ideation
AbstractThe COVID-19 pandemic contributed to worsening mental health across the globe. The pandemic may have been especially impactful on those experiencing heightened psychosis spectrum symptomatology given greater pre-pandemic social isolation and increased vulnerability to stress. Yet, few studies exploring the impact of the COVID-19 pandemic on perceptions of social relationships and mental health have sampled individuals high in psychosis spectrum symptomatology, including those with psychosis spectrum disorders. Utilizing a mixed transdiagnostic community sample enriched for psychotic spectrum disorders, this longitu...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 13, 2024 Category: Neuroscience Source Type: research

Association of empathy with clinical symptoms and cognitive function in chronic schizophrenia patients with and without suicide attempts
AbstractCognitive impairment is recognized as a risk factor for suicide in schizophrenia (SZ) patients. Despite empathy being an important aspect of social cognition, the association between suicidal behavior and empathy has received little attention. We aimed to compare empathy and neurocognition in SZ patients with and without suicide attempts (SAs), and to explore the relationship between empathy, neurocognition, and clinical symptoms in SZ patients with and without SAs. Data on SAs and socio-demographic characteristics were collected from 628 chronic SZ patients. The patients ’ symptomatology was measured by the Posi...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 13, 2024 Category: Neuroscience Source Type: research

The impact of the COVID-19 pandemic on perceptions of social relationships, negative affect, and paranoid ideation
AbstractThe COVID-19 pandemic contributed to worsening mental health across the globe. The pandemic may have been especially impactful on those experiencing heightened psychosis spectrum symptomatology given greater pre-pandemic social isolation and increased vulnerability to stress. Yet, few studies exploring the impact of the COVID-19 pandemic on perceptions of social relationships and mental health have sampled individuals high in psychosis spectrum symptomatology, including those with psychosis spectrum disorders. Utilizing a mixed transdiagnostic community sample enriched for psychotic spectrum disorders, this longitu...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 13, 2024 Category: Neuroscience Source Type: research