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Lavender oil preparation Silexan is effective in mild-to-moderate major depression: a randomized, placebo- and reference-controlled trial
Eur Arch Psychiatry Clin Neurosci. 2024 Apr 1. doi: 10.1007/s00406-024-01783-2. Online ahead of print.ABSTRACTAnxiety and depressive disorders have overlapping symptoms and share common neurobiological pathways. Antidepressant drugs have been demonstrated to be efficacious in anxiety as well. Vice versa, it may also be promising to investigate the efficacy of anxiolytic drugs such as silexan in major depressive disorder (MDD). Patients with a mild or moderate, single or recurrent episode of MDD and a total score of 19-34 points on the Montgomery Åsberg Depression Rating Scale (MADRS) were randomized to receive 1 × 80 mg/...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 1, 2024 Category: Psychiatry Authors: Siegfried Kasper Hans-Peter Volz Hans-J ürgen Möller Sandra Schl äfke Stephan Klement Ion-George Anghelescu Erich Seifritz Source Type: research

Minor tranquillizers for short-term treatment of newly onset symptoms of anxiety and distress: a systematic review with network meta-analysis of randomized trials
AbstractUnspecific symptoms of anxiety and distress are frequently encountered in patients in both general practice and acute psychiatric services. Minor tranquillizers may be a treatment option when non-pharmacological interventions are insufficient or unavailable. We conducted a systematic review with network meta-analysis of the evidence for short-term (1 –4 weeks) pharmacological treatment of newly onset symptoms of anxiety and distress. We searched the PsycInfo, MEDLINE, EMBASE and Cochrane Library databases and extracted data following a predefined hierarchy of outcomes. We assessed risk of bias using the Cochrane...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 1, 2024 Category: Neuroscience Source Type: research

Multiomics and blood-based biomarkers of electroconvulsive therapy in severe and treatment-resistant depression: study protocol of the DetECT study
AbstractElectroconvulsive therapy (ECT) is commonly used to treat treatment-resistant depression (TRD). However, our knowledge of the ECT-induced molecular mechanisms causing clinical improvement is limited. To address this issue, we developed the single-center, prospective observational DetECT study ( “Multimodal Biomarkers of ECT in TRD”; registered 18/07/2022,www.clinicalTrials.gov, NCT05463562). Its objective is to identify molecular, psychological, socioeconomic, and clinical biomarkers of ECT response in TRD. We aim to recruitn = 134 patients in 3 years. Over the course of 12 biweekly ECT sessions (± 7 w...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 1, 2024 Category: Neuroscience Source Type: research

Lavender oil preparation Silexan is effective in mild-to-moderate major depression: a randomized, placebo- and reference-controlled trial
AbstractAnxiety and depressive disorders have overlapping symptoms and share common neurobiological pathways. Antidepressant drugs have been demonstrated to be efficacious in anxiety as well. Vice versa, it may also be promising to investigate the efficacy of anxiolytic drugs such as silexan in major depressive disorder (MDD). Patients with a mild or moderate, single or recurrent episode of MDD and a total score of 19 –34 points on the Montgomery Åsberg Depression Rating Scale (MADRS) were randomized to receive 1 × 80 mg/d silexan, 1 × 50 mg/d sertraline, or placebo double-blind, double-dummy for 56 days. T...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 1, 2024 Category: Neuroscience Source Type: research

Stacked artificial neural network to predict the mental illness during the COVID-19 pandemic
This study’s prediction can help rapid diagnosis and treatment and promote overall public mental health. Despite potential response bias, these proportions are exceptionally elevated, and it’s plausible that certain individuals face an even higher level of risk. In the context of the COVID-19 pandemic, an investigation into mental health patients revealed a disproportionate representation of children and individuals with neurotic disorders among those articulating substantial or severe apprehensions. (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - April 1, 2024 Category: Neuroscience Source Type: research

Sex differences in anhedonia in bipolar depression: a resting-state fMRI study
This study aims to explore the regional brain neuroimaging features of BD with anhedonia and the sex differences in these patients. The resting-fMRI by applying fractional amplitude of low-frequency fluctuation (fALFF) method was estimated in 263 patients with BD (174 high anhedonia [HA], 89 low anhedonia [LA]) and 213 healthy controls. The effects of two different factors in patients with BD were analyzed using a 3 (group: HA, LA, HC) × 2 (sex: male, female) ANOVA. The fALFF values were higher in the HA group than in the LA group in the right medial cingulate gyrus and supplementary motor area. For the sex-by-group inter...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 1, 2024 Category: Neuroscience Source Type: research

Comparing the latent state-trait structure of the PANSS in cariprazine-medicated and placebo-controlled patients with acute schizophrenia
Eur Arch Psychiatry Clin Neurosci. 2024 Mar 29. doi: 10.1007/s00406-024-01790-3. Online ahead of print.ABSTRACTAfter over a hundred years of research, the question whether the symptoms of schizophrenia are rather trait-like (being a relatively stable quality of individuals) or state-like (being substance to change) is still unanswered. To assess the trait and the state component in patients with acute schizophrenia, one group receiving antipsychotic treatment, the other not. Data from four phase II/III, 6-week, randomized, double-blind, placebo-controlled trials of similar design that included patients with acute exacerbat...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 30, 2024 Category: Psychiatry Authors: Jana S Kr ückl K ároly Acsai Zs ófia B Dombi Julian Moeller Roselind Lieb Undine E Lang Ágota Barabássy Christian G Huber Source Type: research

Exposure to psychotropic drugs and breast cancer risk in patients with bipolar disorder and major depressive disorder: a nested case-control study
This study aimed to assess such risk among women with major depressive disorder (MDD) and bipolar disorder (BD). A nested case-control study design was used with data obtained from the Taiwan National Health Insurance Research Database. Logistic regression analysis with adjustments for demographic characteristics, medical and mental comorbidities, and all-cause clinical visits was performed to estimate the risk of breast cancer according to the cumulative defined daily dose (cDDD) of psychotropic drugs. The study included 1564 women with MDD or BD who had breast cancer, and 15,540 women with MDD or BD who did not have brea...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 30, 2024 Category: Psychiatry Authors: Dian-Jeng Li Shih-Jen Tsai Tzeng-Ji Chen Chih-Sung Liang Mu-Hong Chen Source Type: research

Exposure to psychotropic drugs and breast cancer risk in patients with bipolar disorder and major depressive disorder: a nested case –control study
This study aimed to assess such risk among women with major depressive disorder (MDD) and bipolar disorder (BD). A nested case –control study design was used with data obtained from the Taiwan National Health Insurance Research Database. Logistic regression analysis with adjustments for demographic characteristics, medical and mental comorbidities, and all-cause clinical visits was performed to estimate the risk of breast cancer according to the cumulative defined daily dose (cDDD) of psychotropic drugs. The study included 1564 women with MDD or BD who had breast cancer, and 15,540 women with MDD or BD who did not have b...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 30, 2024 Category: Neuroscience Source Type: research

Predictors of adherence to exercise interventions in people with schizophrenia
Eur Arch Psychiatry Clin Neurosci. 2024 Mar 29. doi: 10.1007/s00406-024-01789-w. Online ahead of print.ABSTRACTExercise interventions are nowadays considered as effective add-on treatments in people with schizophrenia but are usually associated with high dropout rates. Therefore, the present study investigated potential predictors of adherence from a large multicenter study, encompassing two types of exercise training, conducted over a 6-month period with individuals with schizophrenia. First, we examined the role of multiple participants' characteristics, including levels of functioning, symptom severity, cognitive perfor...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 29, 2024 Category: Psychiatry Authors: Rebecca Schwaiger Isabel Maurus Moritz Lembeck Irina Papazova David Greska Susanne Muenz Eliska Sykorova Cristina E Thieme Bob O Vogel Sebastian Mohnke Charlotte Huppertz Astrid Roeh Katriona Keller-Varady Berend Malchow Henrik Walter Bernd Wolfarth Wolfg Source Type: research

Predictors of adherence to exercise interventions in people with schizophrenia
AbstractExercise interventions are nowadays considered as effective add-on treatments in people with schizophrenia but are usually associated with high dropout rates. Therefore, the present study investigated potential predictors of adherence from a large multicenter study, encompassing two types of exercise training, conducted over a 6-month period with individuals with schizophrenia. First, we examined the role of multiple participants ’ characteristics, including levels of functioning, symptom severity, cognitive performance, quality of life, and physical fitness. Second, we usedK-means clustering to identify clinical...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 29, 2024 Category: Neuroscience Source Type: research