Association between psychiatric admissions in patients with schizophrenia and IL-6 plasma levels polygenic score
Eur Arch Psychiatry Clin Neurosci. 2024 Mar 16. doi: 10.1007/s00406-024-01786-z. Online ahead of print.ABSTRACTSchizophrenia diagnosis and admission history were associated with a polygenic score (PGS) for schizophrenia based on a subset of variants that act by modifying the expression of genes whose expression is also modified by antipsychotics. This gene set was enriched in cytokine production. Interleukin-6 (IL-6) is the only cytokine whose plasma levels were associated both with schizophrenia diagnosis and with acute decompensations in the largest meta-analysis. Therefore, we hypothesized that an IL-6 PGS, but not othe...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 16, 2024 Category: Psychiatry Authors: Fernando Facal Manuel Arrojo Mario P áramo Javier Costas Source Type: research

Proinflammatory cytokine levels, cognitive function, and suicidal symptoms of adolescents and young adults with major depressive disorder
Eur Arch Psychiatry Clin Neurosci. 2024 Mar 16. doi: 10.1007/s00406-024-01780-5. Online ahead of print.ABSTRACTWhether proinflammatory cytokine dysregulation and cognitive dysfunction are associated with suicidal symptoms in adolescents and young adults with major depressive disorder (MDD) remains uncertain. We assessed the cognitive function and proinflammatory cytokine levels of 43 and 51 patients aged 15-29 years with MDD and severe and mild suicidal symptoms, respectively, as well as those of 85 age- and sex-matched healthy controls. Specifically, we measured serum levels of C-reactive protein, tumor necrosis factor-α...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 16, 2024 Category: Psychiatry Authors: Mu-Hong Chen Ya-Mei Bai Ju-Wei Hsu Kai-Lin Huang Shih-Jen Tsai Source Type: research

Proinflammatory cytokine levels, cognitive function, and suicidal symptoms of adolescents and young adults with major depressive disorder
AbstractWhether proinflammatory cytokine dysregulation and cognitive dysfunction are associated with suicidal symptoms in adolescents and young adults with major depressive disorder (MDD) remains uncertain. We assessed the cognitive function and proinflammatory cytokine levels of 43 and 51 patients aged 15 –29 years with MDD and severe and mild suicidal symptoms, respectively, as well as those of 85 age- and sex-matched healthy controls. Specifically, we measured serum levels of C-reactive protein, tumor necrosis factor-α (TNF-α), interleukin-2, and interleukin-6 and assessed cognitive function b y using working memor...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 16, 2024 Category: Neuroscience Source Type: research

Predictors of effective therapy among individuals with Cannabis Use Disorder: a review of the literature
AbstractTreatment demand for Cannabis Use Disorder (CUD) has increased in the past decade in almost all European countries, and CUD is currently the most common reason for first-time drug-related treatment admission in the European Union. Even though several therapeutic approaches have been shown to benefit individuals with CUD, there is a lack of knowledge regarding factors associated with effective therapy and the underlying mechanisms of change among individuals with CUD presenting for treatment. The aim of the present paper was to review current knowledge on factors that have been shown to contribute to positive outcom...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 16, 2024 Category: Neuroscience Source Type: research

Association between psychiatric admissions in patients with schizophrenia and IL-6 plasma levels polygenic score
AbstractSchizophrenia diagnosis and admission history were associated with a polygenic score (PGS) for schizophrenia based on a subset of variants that act by modifying the expression of genes whose expression is also modified by antipsychotics. This gene set was enriched in cytokine production. Interleukin-6 (IL-6) is the only cytokine whose plasma levels were associated both with schizophrenia diagnosis and with acute decompensations in the largest meta-analysis. Therefore, we hypothesized that an IL-6 PGS, but not other cytokines PGSs, would be associated with schizophrenia chronicity/psychiatric admissions. Using the I...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 16, 2024 Category: Neuroscience Source Type: research

Prevalence and associated factors of obesity in patients with major depressive disorder at different ages of onset
This study totally recruited 1718 first-episode drug-naive MDD patients aged from 18 to 60 years. All subjects were divided into two subgroups: early adulthood onset (EAO, 18-45 years) and mid-adulthood onset (MAO, 45-60 years). Clinical symptoms of patients were evaluated using the 17-item Hamilton Depression Rating Scale (HAMD-17), Hamilton Anxiety Scale (HAMA), and Positive and Negative Syndrome Scale (PANSS) positive subscale. Baseline parameters including body mass index (BMI), blood pressure, and hematological biochemical parameters were assessed to investigate the association between these parameters and weight gain...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 15, 2024 Category: Psychiatry Authors: Xiaoen Liu Xue Tian Lina Wang Xiangyang Zhang Source Type: research

Cannabis use and cannabis use disorders and their treatment in the Europe
Eur Arch Psychiatry Clin Neurosci. 2024 Mar 15. doi: 10.1007/s00406-024-01776-1. Online ahead of print.ABSTRACTThis paper introduces the special issue on cannabis use in Europe. It describes data on the prevalence of cannabis use in Europe and the more limited data on the prevalence of cannabis use disorders, one of the most common forms of drug problem treated in many countries in Europe. It summarises what research has indicated about the adverse effects of acute and chronic cannabis use and discusses potential health system responses that may reduce some of these harms. These include public education about the risks of ...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 15, 2024 Category: Psychiatry Authors: Wayne Hall Jakob Manthey Daniel Stjepanovi ć Source Type: research

Prevalence and associated factors of obesity in patients with major depressive disorder at different ages of onset
This study totally recruited 1718 first-episode drug-naive MDD patients aged from 18 to 60 years. All subjects were divided into two subgroups: early adulthood onset (EAO, 18-45 years) and mid-adulthood onset (MAO, 45-60 years). Clinical symptoms of patients were evaluated using the 17-item Hamilton Depression Rating Scale (HAMD-17), Hamilton Anxiety Scale (HAMA), and Positive and Negative Syndrome Scale (PANSS) positive subscale. Baseline parameters including body mass index (BMI), blood pressure, and hematological biochemical parameters were assessed to investigate the association between these parameters and weight gain...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 15, 2024 Category: Psychiatry Authors: Xiaoen Liu Xue Tian Lina Wang Xiangyang Zhang Source Type: research

Cannabis use and cannabis use disorders and their treatment in the Europe
Eur Arch Psychiatry Clin Neurosci. 2024 Mar 15. doi: 10.1007/s00406-024-01776-1. Online ahead of print.ABSTRACTThis paper introduces the special issue on cannabis use in Europe. It describes data on the prevalence of cannabis use in Europe and the more limited data on the prevalence of cannabis use disorders, one of the most common forms of drug problem treated in many countries in Europe. It summarises what research has indicated about the adverse effects of acute and chronic cannabis use and discusses potential health system responses that may reduce some of these harms. These include public education about the risks of ...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 15, 2024 Category: Psychiatry Authors: Wayne Hall Jakob Manthey Daniel Stjepanovi ć Source Type: research

Cannabis use and cannabis use disorders and their treatment in the Europe
AbstractThis paper introduces the special issue on cannabis use in Europe. It describes data on the prevalence of cannabis use in Europe and the more limited data on the prevalence of cannabis use disorders, one of the most common forms of drug problem treated in many countries in Europe. It summarises what research has indicated about the adverse effects of acute and chronic cannabis use and discusses potential health system responses that may reduce some of these harms. These include public education about the risks of cannabis use; screening and brief interventions in primary medical settings; and specialist treatment f...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 15, 2024 Category: Neuroscience Source Type: research

Prevalence and associated factors of obesity in patients with major depressive disorder at different ages of onset
This study totally recruited 1718 first-episode drug-naive MDD patients aged from 18 to 60  years. All subjects were divided into two subgroups: early adulthood onset (EAO, 18–45 years) and mid-adulthood onset (MAO, 45–60 years). Clinical symptoms of patients were evaluated using the 17-item Hamilton Depression Rating Scale (HAMD-17), Hamilton Anxiety Scale (HAMA), and Positive and Negative Syndrome Scale (PANSS) positive subscale. Baseline parameters including body mass index (BMI), blood pressure, and hematological biochemical parameters were assessed to investigate the association between these parameters and wei...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 15, 2024 Category: Neuroscience Source Type: research

The curious absence of psychosis in GRIN1-related neurodevelopmental disorder
Eur Arch Psychiatry Clin Neurosci. 2024 Mar 14. doi: 10.1007/s00406-024-01796-x. Online ahead of print.NO ABSTRACTPMID:38483682 | DOI:10.1007/s00406-024-01796-x (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - March 14, 2024 Category: Psychiatry Authors: Mark A Colijn Robert M Stowe Source Type: research

The curious absence of psychosis in GRIN1-related neurodevelopmental disorder
(Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - March 14, 2024 Category: Neuroscience Source Type: research