European Archives of Psychiatry and Clinical Neuroscience 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Long-term follow-up of brain regional changes and the association with cognitive impairment in quarantined COVID-19 survivors
ConclusionsOur findings indicate a subjective cognitive decline in quarantined COVID-19 survivors 15 months after discharge, which is associated with brain structural alterations in the left Heschl's gyrus. The observed elevation of inflammatory markers suggests a potential mechanism involving inflammation-induced neurogenesis. These results contribute to our understanding of the possible mechani sms underlying long-term neuropsychiatric consequences of COVID-19 and highlight the need for further research to develop targeted interventions. (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - February 6, 2024 Category: Neuroscience Source Type: research
Assessment of immunoprecipitation with subsequent immunoassays for the blood-based diagnosis of Alzheimer ’s disease
AbstractThe A β42/40 ratio and the concentration of phosphorylated Tau181 in blood plasma represent attractive biomarkers for Alzheimer's disease. As a means for reducing potential matrix effects, which may interfere with plasma immunoassays, we have previously developed a pre-analytical sample workup by semi-au tomated immunoprecipitation. Here we test the compatibility of pre-analytical immunoprecipitations with automated Aβ1-40, Aβ1-42 and phosphorylated Tau181 immunoassays on the Lumipulse platform and compare the diagnostic performance of the respective immunoprecipitation immunoassay approaches with direct plasma ...
Source: European Archives of Psychiatry and Clinical Neuroscience - February 6, 2024 Category: Neuroscience Source Type: research
Long-term follow-up of brain regional changes and the association with cognitive impairment in quarantined COVID-19 survivors
ConclusionsOur findings indicate a subjective cognitive decline in quarantined COVID-19 survivors 15 months after discharge, which is associated with brain structural alterations in the left Heschl's gyrus. The observed elevation of inflammatory markers suggests a potential mechanism involving inflammation-induced neurogenesis. These results contribute to our understanding of the possible mechani sms underlying long-term neuropsychiatric consequences of COVID-19 and highlight the need for further research to develop targeted interventions. (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - February 6, 2024 Category: Neuroscience Source Type: research
Assessment of immunoprecipitation with subsequent immunoassays for the blood-based diagnosis of Alzheimer's disease
Eur Arch Psychiatry Clin Neurosci. 2024 Feb 6. doi: 10.1007/s00406-023-01751-2. Online ahead of print.ABSTRACTThe Aβ42/40 ratio and the concentration of phosphorylated Tau181 in blood plasma represent attractive biomarkers for Alzheimer's disease. As a means for reducing potential matrix effects, which may interfere with plasma immunoassays, we have previously developed a pre-analytical sample workup by semi-automated immunoprecipitation. Here we test the compatibility of pre-analytical immunoprecipitations with automated Aβ1-40, Aβ1-42 and phosphorylated Tau181 immunoassays on the Lumipulse platform and compare the dia...
Source: European Archives of Psychiatry and Clinical Neuroscience - February 5, 2024 Category: Psychiatry Authors: Barbara Morgado Hans-Wolfgang Klafki Chris Bauer Katharina Waniek Hermann Esselmann Oliver Wirths Niels Hansen Ingolf Lachmann Dirk Osterloh Johannes Schuchhardt Jens Wiltfang Source Type: research
Identifying novel chemical-related susceptibility genes for five psychiatric disorders through integrating genome-wide association study and tissue-specific 3'aQTL annotation datasets
In this study, we aim to search novel susceptibility genes, pathways, and related chemicals of five psychiatric disorders via GWAS and 3'aQTLs datasets. The GWAS datasets of five psychiatric disorders were collected from the open platform of Psychiatric Genomics Consortium (PGC, https://www.med.unc.edu/pgc/ ) and iPSYCH ( https://ipsych.dk/ ) (Demontis et al. in Nat Genet 51(1):63-75, 2019; Grove et al. in Nat Genet 51:431-444, 2019; Genomic Dissection of Bipolar Disorder and Schizophrenia in Cell 173: 1705-1715.e1716, 2018; Mullins et al. in Nat Genet 53: 817-829; Howard et al. in Nat Neurosci 22: 343-352, 2019). The 3'un...
Source: European Archives of Psychiatry and Clinical Neuroscience - February 2, 2024 Category: Psychiatry Authors: Sirong Shi Huijie Zhang Xiaoge Chu Qingqing Cai Dan He Xiaoyue Qin Wenming Wei Na Zhang Yijing Zhao Yumeng Jia Feng Zhang Yan Wen Source Type: research
Identifying novel chemical-related susceptibility genes for five psychiatric disorders through integrating genome-wide association study and tissue-specific 3 ′aQTL annotation datasets
In this study, we aim to search novel susceptibility genes, pathways, and related chemicals of five psychiatric disorders via GWAS and 3ʹaQTLs datasets. The GWAS datasets of five psychiatric disorders were collected from the open platform of Psychiatric Genomics Consortium (PGC,https://www.med.unc.edu/pgc/) and iPSYCH (https://ipsych.dk/) (Demontis et al. in Nat Genet 51(1):63 –75, 2019; Grove et al. in Nat Genet 51:431–444, 2019; Genomic Dissection of Bipolar Disorder and Schizophrenia in Cell 173: 1705-1715.e1716, 2018; Mullins et al. in Nat Genet 53: 817–829; Howard et al. in Nat Neurosci 22: 343–352, 2019). Th...
Source: European Archives of Psychiatry and Clinical Neuroscience - February 2, 2024 Category: Neuroscience Source Type: research
Excess mortality and its causes among older adults with schizophrenia versus those with bipolar disorder and major depressive disorder: a 5-year prospective multicenter study
Eur Arch Psychiatry Clin Neurosci. 2024 Jan 31. doi: 10.1007/s00406-023-01752-1. Online ahead of print.ABSTRACTExcess mortality observed in people with schizophrenia may persist in later life. The specific causes of increased mortality observed in older adults with schizophrenia and the potential influence of psychotropic medications remain partly unknown. We compared 5-year mortality and its causes of older adults with schizophrenia to bipolar disorder (BD) or major depressive disorder (MDD). We used a 5-year prospective cohort, including 564 older inpatients and outpatients with schizophrenia, BD or MDD (mean age: 67.9 y...
Source: European Archives of Psychiatry and Clinical Neuroscience - January 31, 2024 Category: Psychiatry Authors: Nicolas Hoertel Marina S ánchez-Rico Sandra Abou Kassm Benjamin Brami Mark Olfson Katayoun Rezaei Valentin Scheer Fr édéric Limosin CSA Study Group Source Type: research
Cognitive reserve, depressive symptoms, obesity, and change in employment status predict mental processing speed and executive function after COVID-19
This study aimed to identify the sociodemographic, clinical, and lifestyle characteristics that characterize a group of post-COVID-19 condition (PCC) participants with neuropsychological impairment. The study sample included 426 participants with PCC who underwent a neurobehavioral evaluation. We selected seven mental speed processing and executive function variables to obtain a data-driven partition. Clustering algorithms were applied, including K-means, bisecting K-means, and Gaussian mixture models. Different machine learning algorithms were then used to obtain a classifier able to separate the two clusters according to...
Source: European Archives of Psychiatry and Clinical Neuroscience - January 29, 2024 Category: Psychiatry Authors: Mar Ariza Javier B éjar Cristian Barru é Neus Cano B àrbara Segura NAUTILUS Project Collaborative Group Claudio Ulises Cort és Carme Junqu é Maite Garolera Source Type: research
A prospective study of the effect of COVID-19 on psychiatric symptoms and sleep problems from infection to 9-month follow-up
Eur Arch Psychiatry Clin Neurosci. 2024 Jan 28. doi: 10.1007/s00406-023-01755-y. Online ahead of print.ABSTRACTDiverse psychological consequences of the COVID-19 pandemic have been reported for 6 months after infection. We conducted a prospective study to evaluate the psychological impact of COVID-19 infection in newly diagnosed cases that were followed up at 1, 6, and 9 months after infection. 137 people were recruited and divided into four groups based on the COVID-19 Treatment Guidelines. They were evaluated using the Pittsburgh Sleep Quality Index (PSQI), Post-traumatic stress disorder Checklist for DSM-5 (PCL-5), and ...
Source: European Archives of Psychiatry and Clinical Neuroscience - January 28, 2024 Category: Psychiatry Authors: Reham M El-Morshedy Maha M El-Kholy Eman M Khedr Gellan K Ahmed Esraa Yassin Marwan N Mohamed Source Type: research
Long-term medication for ADHD (LMA) trial: 2-year prospective observational study in children and adolescents. Core symptoms, daily functioning, and comorbidity outcomes
Eur Arch Psychiatry Clin Neurosci. 2024 Jan 27. doi: 10.1007/s00406-023-01744-1. Online ahead of print.ABSTRACTMore knowledge is needed about long-term ADHD medication and symptom, daily functioning, comorbidity, and tolerability outcomes. This "Long-term Medication for ADHD (LMA) trial" was a prospective observational 2-year trial in children and adolescents aged 6-18 years (extension of 1-year trial). Participants met criteria for DSM-5 ADHD (inattentive or combined), with complex comorbidities; autism spectrum disorder (31%), autistic traits (24%), oppositional symptoms (59%), anxiety (32%), dyslexia/language disorder (...
Source: European Archives of Psychiatry and Clinical Neuroscience - January 27, 2024 Category: Psychiatry Authors: M Johnson J Åsberg Johnels S Östlund K Jakobsson J H ögstedt P Javid Larsson C Gillberg E Billstedt Source Type: research
Interacting with autistic virtual characters: intrapersonal synchrony of nonverbal behavior affects participants' perception
Eur Arch Psychiatry Clin Neurosci. 2024 Jan 25. doi: 10.1007/s00406-023-01750-3. Online ahead of print.ABSTRACTTemporal coordination of communicative behavior is not only located between but also within interaction partners (e.g., gaze and gestures). This intrapersonal synchrony (IaPS) is assumed to constitute interpersonal alignment. Studies show systematic variations in IaPS in individuals with autism, which may affect the degree of interpersonal temporal coordination. In the current study, we reversed the approach and mapped the measured nonverbal behavior of interactants with and without ASD from a previous study onto ...
Source: European Archives of Psychiatry and Clinical Neuroscience - January 25, 2024 Category: Psychiatry Authors: Carola Bloch Ralf Tepest Sevim Koeroglu Kyra Feikes Mathis Jording Kai Vogeley Christine M Falter-Wagner Source Type: research
Plasma Apo-E mediated corticospinal tract abnormalities and suicidality in patients with major depressive disorder
This study aims to explore the link between Apo-E, brain white matter, and suicide in patients with major depressive disorder (MDD) to investigate the potential neuroimmune mechanisms of Apo-E that may lead to suicide. Thirty-nine patients with MDD (22 patients with suicidality) and 57 age, gender, and education-matched healthy controls participated in this study, provided plasma Apo-E samples, and underwent diffusion tensor imaging scans. Plasma Apo-E levels and white matter microstructure were analyzed among the MDD with suicidality, MDD without suicidality, and HC groups using analysis of variance with post hoc Bonferro...
Source: European Archives of Psychiatry and Clinical Neuroscience - January 24, 2024 Category: Psychiatry Authors: Xiaoxia Lei Xinyu Fang Juanjuan Ren Xinyue Teng Chaoyue Guo Zenan Wu Lingfang Yu Dandan Wang Yan Chen Yunshan Zhou Yujie Wu Yi Zhang Chen Zhang Source Type: research
Specific association between retinal neural layer thinning and neurological soft signs in schizophrenia
Eur Arch Psychiatry Clin Neurosci. 2024 Jan 20. doi: 10.1007/s00406-023-01742-3. Online ahead of print.ABSTRACTThere is growing evidence of disproportionate retinal thinning in schizophrenia, but doubts are still raised regarding its significance in the context of the neurobiology of the disease. Therefore, we examined whether these abnormalities are significantly associated with neurological soft signs (NSS) which are closely related to the risk of schizophrenia. This cross-sectional study analyzing linear correlations between variables involved 56 schizophrenia inpatients and 60 controls. The results confirmed such relat...
Source: European Archives of Psychiatry and Clinical Neuroscience - January 20, 2024 Category: Psychiatry Authors: Pawe ł Krukow Adam Domaga ła Steven M Silverstein Source Type: research
Soluble terminal complement complex blood levels are elevated in schizophrenia
Eur Arch Psychiatry Clin Neurosci. 2024 Jan 19. doi: 10.1007/s00406-023-01738-z. Online ahead of print.ABSTRACTThe role of the complement system in schizophrenia (Sz) is inconclusive due to heterogeneity of the disease and study designs. Here, we assessed the levels of complement activation products and functionality of the classical pathway in acutely ill unmedicated Sz patients at baseline and after 6 weeks of treatment versus matched controls. The study included analyses of the terminal complement complex (sTCC) and C5a in plasma from 96 patients and 96 controls by enzyme-linked immunosorbent assay. Sub-group analysis o...
Source: European Archives of Psychiatry and Clinical Neuroscience - January 19, 2024 Category: Psychiatry Authors: Susa Savukoski Marco Mannes Lisa Wohlgemuth Anke Schultze Paul C Guest Gabriela Meyer-Lotz Henrik Dobrowolny Borna Relja Markus Huber-Lang Johann Steiner Source Type: research
