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Disparate Formulations for Machine Perfusion: A Survey of Organ Procurement Organizations' Medication Additives and Outcome Analyses
Exp Clin Transplant. 2021 Nov;19(11):1124-1132. doi: 10.6002/ect.2021.0037.ABSTRACTOBJECTIVES: Machine perfusionfor kidney preservation is a common practice. There is no consensus on the best formula for perfusion solutions. We aimed to discern the additives that organ procurement organizations in the United States include in their perfusate and the impact of these additives on transplant outcomes.MATERIALS AND METHODS: A telephone survey of all 58 organ procurement organizations in the United States regarding additives to their perfusion solutions was conducted. The survey data were merged with transplant recipient outcom...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Ankur P Choubey Emily W Rady Naoru Koizumi Abu B Siddique Paul Wiederhold Jorge Ortiz Source Type: research

The New UK National Kidney Allocation Scheme With Maximized "R4-D4" Kidney Transplants: Better Patient-to-Graft Longevity Matching May Be at the Cost of More Resources
We present data on 2 years of transplants, with the aim of understanding the potential impacts ofthe scheme on patient/transplant outcomes, hospitalization, and resource utilization.MATERIALS AND METHODS: All deceased donortransplants from 2015 and 2016 were reclassified using the risk quartiles (D1-D4 for donor and R1-R4 for recipient, where 4 is highestrisk). Inpatientlength of stay, kidney function defined by estimated glomerular rate at 1 year, and patient survival data were collected.RESULTS: Of the 195 deceased donor transplants analyzed, 144 recipients (73.4%) were in the highest risk R4 category, including 55 with ...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Robert Pearson Eleanor Murray Peter C Thomson Patrick B Mark Marc J Clancy John Asher Source Type: research

Comparison of FOXP3 and Interleukin 35 Expression Profiles in Kidney Transplant Recipients With Excellent Long-Term Graft Function and Acute Rejection
Exp Clin Transplant. 2021 Nov;19(11):1142-1148. doi: 10.6002/ect.2021.0116.ABSTRACTOBJECTIVES: Transplant tolerance is defined as graft acceptance without long-term use of immunosuppressive agents. Regulatory T cells are involved in the maintenance of peripheral self-tolerance by actively suppressing the activation and expansion of autoreactive T cells. In the present study, we compared the expression profiles of forkhead box protein P3 (FOXP3) and interleukin 35 in kidney transplant recipients who had excellent long-term graft function under immunosuppression versus recipients who had acute rejection.MATERIALS AND METHODS...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Mahsa Torabijahromi Jamshid Roozbeh GhanbarAli Raeesjalali Maryam Shafiee Nakisa Rasaei Mojdeh Heidari Mohammad Hossein Karimi Source Type: research

Factors Associated With Cytomegalovirus Infection in Pediatric Allogeneic Hematopoietic Stem Cell Transplant Recipients: A Prospective Single-Center Study
CONCLUSIONS: Transplant recipients presented with a high incidence of cytomegalovirus viremia. The modality of allogeneic hematopoietic stem cell transplant was associated with the frequency of cytomegalovirus infection. Age, sex, type of underlying disease, and medically relevant events were not conducive to occurrences of viremia. Notably, we observed substantial viral loads in female patients and patients with neoplastic diseases. Studies comprising larger populations are needed to better understand these results.PMID:34812706 | DOI:10.6002/ect.2021.0282 (Source: Experimental and Clinical Transplantation : official jour...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Marko Jankovi ć Aleksandra Kne žević Maja Ćupić Dragana Vuji ć Marija Simi ć Željko Zečević Borko Gobelji ć Tanja Jovanovi ć Source Type: research

Development of the Eurotransplant Discard Risk Index to Predict Acceptance of Livers for Transplantation: A Retrospective Database Analysis
This study aimed to evaluate the prognostic ability of an updated Discard Risk Index in Eurotransplant.MATERIALS AND METHODS: Potential deceased donors from January 2010 to December 2015 who had been reported to Eurotransplant were included in our analyses. Liver utilization was defined by transplant status as the primary outcome to evaluate the performance of the Eurotransplant-developed Discard Risk Index.RESULTS: Of 11670 potential livers, 9565 (81%) were actually transplanted. Donor sex, age, history of diabetes, drug abuse, use of vasopressors, body mass index category, serum sodium, cause of death, donor type, and le...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Jacob D de Boer Hein Putter Joris J Blok Nouvel A Cambridge Simen D van den Berg Serge Vogelaar Gabriela Berlakovich Markus Guba Andries E Braat E L I A C Advisory Committee Source Type: research

Preemptive Bundle Therapy for Subclinical Pulmonary Hypertension After Liver Transplant
CONCLUSIONS: Preemptive bundle therapy reduced sinusoidal endothelial cell injury, extrasinusoidal platelet aggregation, and subclinical pulmonary hypertension after liver transplant, resulting in good posttransplant recovery.PMID:34812708 | DOI:10.6002/ect.2021.0176 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Hiroyuki Takamura Yoshinao Ohbatake Sinichi Nakanuma Hironori Hayashi Ryousuke Gabata Isamu Makino Tomoharu Miyashita Hidehiro Tajima Shintaro Yagi Tetsuo Ohta Source Type: research

Analysis of 23 Years of Cornea Donor Data From an Eye Bank in Turkey
CONCLUSIONS: This study evaluated the most extensive eye bank data in Turkey and found that advances in lamellar surgery techniques and improvements in specular microscopic facilities have expanded the pool for cornealtransplants to include tissues from older donors. Moreover, the incidence rates for HIVpositive and syphilis-positive serology tests in discarded corneas have increased over time.PMID:34812709 | DOI:10.6002/ect.2021.0072 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Emre Altinkurt Zafer Cebeci Ozkan Avci Kemal Turgay Ozbilen Nilufer Alparslan Source Type: research

Pancreas Donor Risk Index and Preprocurement Pancreas Suitability Score for Prediction of Pancreas Transplant Outcomes
Exp Clin Transplant. 2021 Nov;19(11):1197-1203. doi: 10.6002/ect.2021.0263.ABSTRACTOBJECTIVES: The Pancreas Donor Risk Index and Preprocurement Pancreas Suitability Score were designed to assist in the evaluation of pancreases for transplant. Preprocurement Pancreas Suitability Score 1.57 groups, respectively (P = .047). We calculated Preprocurement Pancreas Suitability Scores for 129 patients, and 12 (21%) and 27 (32%) were in the
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Ky-Leigh Ang Argiris Asderakis Mohamed Adel Ilham Doruk Elker Aeliya Zaidi Elijah Ablorsu Usman Khalid Source Type: research

Effect of Sertoli Cell Transplant and Rapamycin Pretreatment on Middle Cerebral Artery Occlusion-Induced Brain Ischemia in a Rat Model
CONCLUSIONS: Pretreatment with Sertoli cell transplant plus rapamycin injection may enhance neural survival during ischemia through increased glial cell-derived neurotrophic factor and vascular endothelial growth factor, inhibiting the mechanistic target of rapamycin pathway and increasing autophagy performance.PMID:34812711 | DOI:10.6002/ect.2021.0198 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Sara Moradpour Abbas Aliaghaei Mohammadreza Bigdeli Source Type: research

Complete Remission of Refractory Immunothrombocytopenic Purpura After Tacrolimus Replacement With Cyclosporine in a Case of Living Related Liver Transplant
Exp Clin Transplant. 2021 Nov;19(11):1228-1231. doi: 10.6002/ect.2021.0272.ABSTRACTImmunothrombocytopenic purpura is a possible complication after liver transplant. The therapy for immunothrombocytopenic purpura after liver transplant is similar to that of primary immunothrombocytopenic purpura. This therapy consists of corticosteroids, intravenous immunoglobulin, and immunosuppressive agents such as cyclosporine and rituximab. There are a few cases of immunothrombocytopenic purpura in patients who recovered after cessation of tacrolimus administration. Here, we show an intractable case of immunothrombocytopenic purpura in...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Masayoshi Hamaguchi Rieko Sakamoto Kensaku Kohrogi Takahiro Yamashita Keishiro Furuie Tadashi Anan Kimitoshi Nakamura Source Type: research

Disparate Formulations for Machine Perfusion: A Survey of Organ Procurement Organizations' Medication Additives and Outcome Analyses
Exp Clin Transplant. 2021 Nov;19(11):1124-1132. doi: 10.6002/ect.2021.0037.ABSTRACTOBJECTIVES: Machine perfusionfor kidney preservation is a common practice. There is no consensus on the best formula for perfusion solutions. We aimed to discern the additives that organ procurement organizations in the United States include in their perfusate and the impact of these additives on transplant outcomes.MATERIALS AND METHODS: A telephone survey of all 58 organ procurement organizations in the United States regarding additives to their perfusion solutions was conducted. The survey data were merged with transplant recipient outcom...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Ankur P Choubey Emily W Rady Naoru Koizumi Abu B Siddique Paul Wiederhold Jorge Ortiz Source Type: research

The New UK National Kidney Allocation Scheme With Maximized "R4-D4" Kidney Transplants: Better Patient-to-Graft Longevity Matching May Be at the Cost of More Resources
We present data on 2 years of transplants, with the aim of understanding the potential impacts ofthe scheme on patient/transplant outcomes, hospitalization, and resource utilization.MATERIALS AND METHODS: All deceased donortransplants from 2015 and 2016 were reclassified using the risk quartiles (D1-D4 for donor and R1-R4 for recipient, where 4 is highestrisk). Inpatientlength of stay, kidney function defined by estimated glomerular rate at 1 year, and patient survival data were collected.RESULTS: Of the 195 deceased donor transplants analyzed, 144 recipients (73.4%) were in the highest risk R4 category, including 55 with ...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Robert Pearson Eleanor Murray Peter C Thomson Patrick B Mark Marc J Clancy John Asher Source Type: research

Comparison of FOXP3 and Interleukin 35 Expression Profiles in Kidney Transplant Recipients With Excellent Long-Term Graft Function and Acute Rejection
Exp Clin Transplant. 2021 Nov;19(11):1142-1148. doi: 10.6002/ect.2021.0116.ABSTRACTOBJECTIVES: Transplant tolerance is defined as graft acceptance without long-term use of immunosuppressive agents. Regulatory T cells are involved in the maintenance of peripheral self-tolerance by actively suppressing the activation and expansion of autoreactive T cells. In the present study, we compared the expression profiles of forkhead box protein P3 (FOXP3) and interleukin 35 in kidney transplant recipients who had excellent long-term graft function under immunosuppression versus recipients who had acute rejection.MATERIALS AND METHODS...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Mahsa Torabijahromi Jamshid Roozbeh GhanbarAli Raeesjalali Maryam Shafiee Nakisa Rasaei Mojdeh Heidari Mohammad Hossein Karimi Source Type: research

Factors Associated With Cytomegalovirus Infection in Pediatric Allogeneic Hematopoietic Stem Cell Transplant Recipients: A Prospective Single-Center Study
CONCLUSIONS: Transplant recipients presented with a high incidence of cytomegalovirus viremia. The modality of allogeneic hematopoietic stem cell transplant was associated with the frequency of cytomegalovirus infection. Age, sex, type of underlying disease, and medically relevant events were not conducive to occurrences of viremia. Notably, we observed substantial viral loads in female patients and patients with neoplastic diseases. Studies comprising larger populations are needed to better understand these results.PMID:34812706 | DOI:10.6002/ect.2021.0282 (Source: Experimental and Clinical Transplantation : official jour...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Marko Jankovi ć Aleksandra Kne žević Maja Ćupić Dragana Vuji ć Marija Simi ć Željko Zečević Borko Gobelji ć Tanja Jovanovi ć Source Type: research

Development of the Eurotransplant Discard Risk Index to Predict Acceptance of Livers for Transplantation: A Retrospective Database Analysis
This study aimed to evaluate the prognostic ability of an updated Discard Risk Index in Eurotransplant.MATERIALS AND METHODS: Potential deceased donors from January 2010 to December 2015 who had been reported to Eurotransplant were included in our analyses. Liver utilization was defined by transplant status as the primary outcome to evaluate the performance of the Eurotransplant-developed Discard Risk Index.RESULTS: Of 11670 potential livers, 9565 (81%) were actually transplanted. Donor sex, age, history of diabetes, drug abuse, use of vasopressors, body mass index category, serum sodium, cause of death, donor type, and le...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Jacob D de Boer Hein Putter Joris J Blok Nouvel A Cambridge Simen D van den Berg Serge Vogelaar Gabriela Berlakovich Markus Guba Andries E Braat E L I A C Advisory Committee Source Type: research

Preemptive Bundle Therapy for Subclinical Pulmonary Hypertension After Liver Transplant
CONCLUSIONS: Preemptive bundle therapy reduced sinusoidal endothelial cell injury, extrasinusoidal platelet aggregation, and subclinical pulmonary hypertension after liver transplant, resulting in good posttransplant recovery.PMID:34812708 | DOI:10.6002/ect.2021.0176 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Hiroyuki Takamura Yoshinao Ohbatake Sinichi Nakanuma Hironori Hayashi Ryousuke Gabata Isamu Makino Tomoharu Miyashita Hidehiro Tajima Shintaro Yagi Tetsuo Ohta Source Type: research

Analysis of 23 Years of Cornea Donor Data From an Eye Bank in Turkey
CONCLUSIONS: This study evaluated the most extensive eye bank data in Turkey and found that advances in lamellar surgery techniques and improvements in specular microscopic facilities have expanded the pool for cornealtransplants to include tissues from older donors. Moreover, the incidence rates for HIVpositive and syphilis-positive serology tests in discarded corneas have increased over time.PMID:34812709 | DOI:10.6002/ect.2021.0072 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Emre Altinkurt Zafer Cebeci Ozkan Avci Kemal Turgay Ozbilen Nilufer Alparslan Source Type: research

Pancreas Donor Risk Index and Preprocurement Pancreas Suitability Score for Prediction of Pancreas Transplant Outcomes
Exp Clin Transplant. 2021 Nov;19(11):1197-1203. doi: 10.6002/ect.2021.0263.ABSTRACTOBJECTIVES: The Pancreas Donor Risk Index and Preprocurement Pancreas Suitability Score were designed to assist in the evaluation of pancreases for transplant. Preprocurement Pancreas Suitability Score 1.57 groups, respectively (P = .047). We calculated Preprocurement Pancreas Suitability Scores for 129 patients, and 12 (21%) and 27 (32%) were in the
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Ky-Leigh Ang Argiris Asderakis Mohamed Adel Ilham Doruk Elker Aeliya Zaidi Elijah Ablorsu Usman Khalid Source Type: research

Effect of Sertoli Cell Transplant and Rapamycin Pretreatment on Middle Cerebral Artery Occlusion-Induced Brain Ischemia in a Rat Model
CONCLUSIONS: Pretreatment with Sertoli cell transplant plus rapamycin injection may enhance neural survival during ischemia through increased glial cell-derived neurotrophic factor and vascular endothelial growth factor, inhibiting the mechanistic target of rapamycin pathway and increasing autophagy performance.PMID:34812711 | DOI:10.6002/ect.2021.0198 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Sara Moradpour Abbas Aliaghaei Mohammadreza Bigdeli Source Type: research

Complete Remission of Refractory Immunothrombocytopenic Purpura After Tacrolimus Replacement With Cyclosporine in a Case of Living Related Liver Transplant
Exp Clin Transplant. 2021 Nov;19(11):1228-1231. doi: 10.6002/ect.2021.0272.ABSTRACTImmunothrombocytopenic purpura is a possible complication after liver transplant. The therapy for immunothrombocytopenic purpura after liver transplant is similar to that of primary immunothrombocytopenic purpura. This therapy consists of corticosteroids, intravenous immunoglobulin, and immunosuppressive agents such as cyclosporine and rituximab. There are a few cases of immunothrombocytopenic purpura in patients who recovered after cessation of tacrolimus administration. Here, we show an intractable case of immunothrombocytopenic purpura in...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Masayoshi Hamaguchi Rieko Sakamoto Kensaku Kohrogi Takahiro Yamashita Keishiro Furuie Tadashi Anan Kimitoshi Nakamura Source Type: research

Disparate Formulations for Machine Perfusion: A Survey of Organ Procurement Organizations' Medication Additives and Outcome Analyses
Exp Clin Transplant. 2021 Nov;19(11):1124-1132. doi: 10.6002/ect.2021.0037.ABSTRACTOBJECTIVES: Machine perfusionfor kidney preservation is a common practice. There is no consensus on the best formula for perfusion solutions. We aimed to discern the additives that organ procurement organizations in the United States include in their perfusate and the impact of these additives on transplant outcomes.MATERIALS AND METHODS: A telephone survey of all 58 organ procurement organizations in the United States regarding additives to their perfusion solutions was conducted. The survey data were merged with transplant recipient outcom...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Ankur P Choubey Emily W Rady Naoru Koizumi Abu B Siddique Paul Wiederhold Jorge Ortiz Source Type: research

The New UK National Kidney Allocation Scheme With Maximized "R4-D4" Kidney Transplants: Better Patient-to-Graft Longevity Matching May Be at the Cost of More Resources
We present data on 2 years of transplants, with the aim of understanding the potential impacts ofthe scheme on patient/transplant outcomes, hospitalization, and resource utilization.MATERIALS AND METHODS: All deceased donortransplants from 2015 and 2016 were reclassified using the risk quartiles (D1-D4 for donor and R1-R4 for recipient, where 4 is highestrisk). Inpatientlength of stay, kidney function defined by estimated glomerular rate at 1 year, and patient survival data were collected.RESULTS: Of the 195 deceased donor transplants analyzed, 144 recipients (73.4%) were in the highest risk R4 category, including 55 with ...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Robert Pearson Eleanor Murray Peter C Thomson Patrick B Mark Marc J Clancy John Asher Source Type: research

Comparison of FOXP3 and Interleukin 35 Expression Profiles in Kidney Transplant Recipients With Excellent Long-Term Graft Function and Acute Rejection
Exp Clin Transplant. 2021 Nov;19(11):1142-1148. doi: 10.6002/ect.2021.0116.ABSTRACTOBJECTIVES: Transplant tolerance is defined as graft acceptance without long-term use of immunosuppressive agents. Regulatory T cells are involved in the maintenance of peripheral self-tolerance by actively suppressing the activation and expansion of autoreactive T cells. In the present study, we compared the expression profiles of forkhead box protein P3 (FOXP3) and interleukin 35 in kidney transplant recipients who had excellent long-term graft function under immunosuppression versus recipients who had acute rejection.MATERIALS AND METHODS...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Mahsa Torabijahromi Jamshid Roozbeh GhanbarAli Raeesjalali Maryam Shafiee Nakisa Rasaei Mojdeh Heidari Mohammad Hossein Karimi Source Type: research

Factors Associated With Cytomegalovirus Infection in Pediatric Allogeneic Hematopoietic Stem Cell Transplant Recipients: A Prospective Single-Center Study
CONCLUSIONS: Transplant recipients presented with a high incidence of cytomegalovirus viremia. The modality of allogeneic hematopoietic stem cell transplant was associated with the frequency of cytomegalovirus infection. Age, sex, type of underlying disease, and medically relevant events were not conducive to occurrences of viremia. Notably, we observed substantial viral loads in female patients and patients with neoplastic diseases. Studies comprising larger populations are needed to better understand these results.PMID:34812706 | DOI:10.6002/ect.2021.0282 (Source: Experimental and Clinical Transplantation : official jour...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Marko Jankovi ć Aleksandra Kne žević Maja Ćupić Dragana Vuji ć Marija Simi ć Željko Zečević Borko Gobelji ć Tanja Jovanovi ć Source Type: research

Development of the Eurotransplant Discard Risk Index to Predict Acceptance of Livers for Transplantation: A Retrospective Database Analysis
This study aimed to evaluate the prognostic ability of an updated Discard Risk Index in Eurotransplant.MATERIALS AND METHODS: Potential deceased donors from January 2010 to December 2015 who had been reported to Eurotransplant were included in our analyses. Liver utilization was defined by transplant status as the primary outcome to evaluate the performance of the Eurotransplant-developed Discard Risk Index.RESULTS: Of 11670 potential livers, 9565 (81%) were actually transplanted. Donor sex, age, history of diabetes, drug abuse, use of vasopressors, body mass index category, serum sodium, cause of death, donor type, and le...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Jacob D de Boer Hein Putter Joris J Blok Nouvel A Cambridge Simen D van den Berg Serge Vogelaar Gabriela Berlakovich Markus Guba Andries E Braat E L I A C Advisory Committee Source Type: research

Preemptive Bundle Therapy for Subclinical Pulmonary Hypertension After Liver Transplant
CONCLUSIONS: Preemptive bundle therapy reduced sinusoidal endothelial cell injury, extrasinusoidal platelet aggregation, and subclinical pulmonary hypertension after liver transplant, resulting in good posttransplant recovery.PMID:34812708 | DOI:10.6002/ect.2021.0176 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Hiroyuki Takamura Yoshinao Ohbatake Sinichi Nakanuma Hironori Hayashi Ryousuke Gabata Isamu Makino Tomoharu Miyashita Hidehiro Tajima Shintaro Yagi Tetsuo Ohta Source Type: research

Analysis of 23 Years of Cornea Donor Data From an Eye Bank in Turkey
CONCLUSIONS: This study evaluated the most extensive eye bank data in Turkey and found that advances in lamellar surgery techniques and improvements in specular microscopic facilities have expanded the pool for cornealtransplants to include tissues from older donors. Moreover, the incidence rates for HIVpositive and syphilis-positive serology tests in discarded corneas have increased over time.PMID:34812709 | DOI:10.6002/ect.2021.0072 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Emre Altinkurt Zafer Cebeci Ozkan Avci Kemal Turgay Ozbilen Nilufer Alparslan Source Type: research

Pancreas Donor Risk Index and Preprocurement Pancreas Suitability Score for Prediction of Pancreas Transplant Outcomes
Exp Clin Transplant. 2021 Nov;19(11):1197-1203. doi: 10.6002/ect.2021.0263.ABSTRACTOBJECTIVES: The Pancreas Donor Risk Index and Preprocurement Pancreas Suitability Score were designed to assist in the evaluation of pancreases for transplant. Preprocurement Pancreas Suitability Score 1.57 groups, respectively (P = .047). We calculated Preprocurement Pancreas Suitability Scores for 129 patients, and 12 (21%) and 27 (32%) were in the
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Ky-Leigh Ang Argiris Asderakis Mohamed Adel Ilham Doruk Elker Aeliya Zaidi Elijah Ablorsu Usman Khalid Source Type: research

Effect of Sertoli Cell Transplant and Rapamycin Pretreatment on Middle Cerebral Artery Occlusion-Induced Brain Ischemia in a Rat Model
CONCLUSIONS: Pretreatment with Sertoli cell transplant plus rapamycin injection may enhance neural survival during ischemia through increased glial cell-derived neurotrophic factor and vascular endothelial growth factor, inhibiting the mechanistic target of rapamycin pathway and increasing autophagy performance.PMID:34812711 | DOI:10.6002/ect.2021.0198 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Sara Moradpour Abbas Aliaghaei Mohammadreza Bigdeli Source Type: research

Complete Remission of Refractory Immunothrombocytopenic Purpura After Tacrolimus Replacement With Cyclosporine in a Case of Living Related Liver Transplant
Exp Clin Transplant. 2021 Nov;19(11):1228-1231. doi: 10.6002/ect.2021.0272.ABSTRACTImmunothrombocytopenic purpura is a possible complication after liver transplant. The therapy for immunothrombocytopenic purpura after liver transplant is similar to that of primary immunothrombocytopenic purpura. This therapy consists of corticosteroids, intravenous immunoglobulin, and immunosuppressive agents such as cyclosporine and rituximab. There are a few cases of immunothrombocytopenic purpura in patients who recovered after cessation of tacrolimus administration. Here, we show an intractable case of immunothrombocytopenic purpura in...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 23, 2021 Category: Transplant Surgery Authors: Masayoshi Hamaguchi Rieko Sakamoto Kensaku Kohrogi Takahiro Yamashita Keishiro Furuie Tadashi Anan Kimitoshi Nakamura Source Type: research

Outcomes of Right and Left Hepatic Arterial Anastomosis in Right Lobe Living Donor Liver Transplant
CONCLUSIONS: Left artery anastomosis was found to be technically safe and feasible and did not adversely affect patient outcome compared with right artery anastomosis. Left hepatic artery anastomosis may also reduce the incidence of the biliary complications compared with the right hepatic artery anastomosis.PMID:34791995 | DOI:10.6002/ect.2020.0309 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 18, 2021 Category: Transplant Surgery Authors: Bhargava Ram Chikkala Rahul Rahul Shaleen Agarwal Aarathi Vijayashanker Yuktansh Pandey Inbaraj Balradja Rajesh Dey Subhash Gupta Source Type: research

Outcomes of Right and Left Hepatic Arterial Anastomosis in Right Lobe Living Donor Liver Transplant
CONCLUSIONS: Left artery anastomosis was found to be technically safe and feasible and did not adversely affect patient outcome compared with right artery anastomosis. Left hepatic artery anastomosis may also reduce the incidence of the biliary complications compared with the right hepatic artery anastomosis.PMID:34791995 | DOI:10.6002/ect.2020.0309 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 18, 2021 Category: Transplant Surgery Authors: Bhargava Ram Chikkala Rahul Rahul Shaleen Agarwal Aarathi Vijayashanker Yuktansh Pandey Inbaraj Balradja Rajesh Dey Subhash Gupta Source Type: research

Outcomes of Right and Left Hepatic Arterial Anastomosis in Right Lobe Living Donor Liver Transplant
CONCLUSIONS: Left artery anastomosis was found to be technically safe and feasible and did not adversely affect patient outcome compared with right artery anastomosis. Left hepatic artery anastomosis may also reduce the incidence of the biliary complications compared with the right hepatic artery anastomosis.PMID:34791995 | DOI:10.6002/ect.2020.0309 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 18, 2021 Category: Transplant Surgery Authors: Bhargava Ram Chikkala Rahul Rahul Shaleen Agarwal Aarathi Vijayashanker Yuktansh Pandey Inbaraj Balradja Rajesh Dey Subhash Gupta Source Type: research

Outcomes of Right and Left Hepatic Arterial Anastomosis in Right Lobe Living Donor Liver Transplant
CONCLUSIONS: Left artery anastomosis was found to be technically safe and feasible and did not adversely affect patient outcome compared with right artery anastomosis. Left hepatic artery anastomosis may also reduce the incidence of the biliary complications compared with the right hepatic artery anastomosis.PMID:34791995 | DOI:10.6002/ect.2020.0309 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 18, 2021 Category: Transplant Surgery Authors: Bhargava Ram Chikkala Rahul Rahul Shaleen Agarwal Aarathi Vijayashanker Yuktansh Pandey Inbaraj Balradja Rajesh Dey Subhash Gupta Source Type: research

Safety and Efficacy of Kidney Transplants From Older Adult Living Donors: A Comparative Analysis of Donor and Recipient Outcomes
Exp Clin Transplant. 2021 Nov 11. doi: 10.6002/ect.2021.0246. Online ahead of print.ABSTRACTOBJECTIVES: We investigated the safety of donor nephrectomy from older adult donors (age ≥60 years), as well as long-term donor, recipient, and graft outcomes.MATERIALS AND METHODS: We retrospectively analyzed data from 307 living donor kidney transplants from 1996 to 2016 and defined 2 cohorts based on donor age. Cohort A comprised donors aged 60 years and older, and cohort B comprised donors from 18 to 59 years old. We recorded donor and recipient perioperative complications, outcomes, and survival rates and used SPSS and MedCa...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 15, 2021 Category: Transplant Surgery Authors: Abbas Ghazanfar Madiha Abbas Laylan Salih Joyce Popoola Ashar Wadoodi Sarah Heap Mysore Phanish Source Type: research

Role of Early Extubation After Orthotopic Liver Transplant
Exp Clin Transplant. 2021 Nov 11. doi: 10.6002/ect.2021.0281. Online ahead of print.NO ABSTRACTPMID:34775935 | DOI:10.6002/ect.2021.0281 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 15, 2021 Category: Transplant Surgery Authors: Benjamin Milne Source Type: research

Positive Association of Serum Adiponectin Level With the Vascular Reactivity Index in Kidney Transplant Patients
Exp Clin Transplant. 2021 Nov 11. doi: 10.6002/ect.2021.0253. Online ahead of print.ABSTRACTOBJECTIVES: Adiponectin has an important role in obesity, insulin resistance, and cardiovascular disease. We investigated the association between serum adiponectin levels and endothelial function in kidney transplant patients.MATERIALS AND METHODS: Fasting blood samples were obtained from 70 kidney transplant patients. The vascular reactivity index was measured with a digital thermal monitoring test. Serum adiponectin levels were measured with a commercially available enzyme immunoassay kit. A vascular reactivity index
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 15, 2021 Category: Transplant Surgery Authors: Wei-Chen Lin Ming-Che Lee Bang-Gee Hsu Source Type: research

Update on Vascular Complications After Renal Transplantation
Exp Clin Transplant. 2021 Nov 10. doi: 10.6002/ect.2021.0303. Online ahead of print.ABSTRACTRenal transplant is the treatment of choice for endstage renal failure. Since the first successful kidney transplant in 1954, advances in immunosuppression, surgical techniques, and posttransplant medical care have drastically improved the outcomes of this procedure. Despite these advances, surgical complications after renal transplant remain a challenge that can result in serious morbidity, graft loss, and recipient mortality. A significant proportion of surgical complications will have a vascular origin. Some of these vascular com...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 15, 2021 Category: Transplant Surgery Authors: Thilina Gunawardena Source Type: research

Risk Factors for Graft-Versus-Host Disease and Survival in Pediatric Hematopoietic Stem Cell Transplant Recipients: A Single-Center Experience
CONCLUSIONS: Although there are some known risk factors for graft-versus-host disease in adult patients, little is known about risk factors in children. In our comprehensive study in pediatric patients, we found that peripheral blood stem cell transplant, female-tomale transplant, and later neutrophil engraftment were associated with incidence of graft-versus-host disease. Although peripheral blood as a source of stem cells and female-to-male transplant are known risk factors, later neutrophil engraftment was a new finding as a possible risk factor for acute graft-versushost disease. This finding requires further verificat...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 15, 2021 Category: Transplant Surgery Authors: Tu ğba Bedir Demirdağ G özde Kurşun Ağlamiş Serap Kirkiz Kayal Asiye U ğraş Dikmen Z ühre Kaya İdil Yenicesu Ülker Koçak Source Type: research

Visceral Leishmaniasis After Kidney Transplant: An Unusual Presentation and Mode of Diagnosis
We describe an unusual presentation of leishmaniasis in a kidney allograft recipient with organomegaly and pancytopenia sans fever detected by isolation of amastigotes in duodenal biopsy. To the best of our knowledge, this is the first case report of this kind in a kidney transplant recipient.PMID:34775939 | DOI:10.6002/ect.2021.0160 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 15, 2021 Category: Transplant Surgery Authors: Abhyudaysingh Rana Ashwini Gadde Lipika Lippi Shyam B Bansal Source Type: research

Hand-Assisted Laparoscopic Subtotal Colectomy for Ogilvie Syndrome Associated With Idiopathic Fibrosis of Colon After Simultaneous Pancreas Kidney Transplant
Exp Clin Transplant. 2021 Nov 10. doi: 10.6002/ect.2021.0306. Online ahead of print.ABSTRACTOgilvie syndrome (acute colonic pseudo-obstruction) is a rare, acquired, life-threatening disorder for which treatment plans vary from simple observation to surgical intervention. Ogilvie syndrome has been reported in patients after renal or liver transplant, but its occurrence after simultaneous pancreas-kidney transplant is rare. Herein, we present the case of a 45-year-old female recipient of a deceased donor simultaneous pancreas-kidney transplant who developed Ogilvie syndrome 10 days after a previous fecal ileus that had resol...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 15, 2021 Category: Transplant Surgery Authors: Tsukasa Nakamura Ryusuke Sugimoto Shumpei Harada Shuji Nobori Hidetaka Ushigome Mikiko Yoshikawa Source Type: research

Acute Kidney Injury After Liver Transplant: Incidence, Risk Factors, and Impact on Patient Outcomes
Exp Clin Transplant. 2021 Nov 10. doi: 10.6002/ect.2021.0300. Online ahead of print.ABSTRACTOBJECTIVES: Acute kidney injury is a frequent complication of liver transplant. Here, we assessed the rate and contributing factors of acute kidney injury and need for renal replacement therapy in patients undergoing liver transplant at a transplant center in Tehran, Iran.MATERIAL AND METHODS: We identified all patients who underwent liver transplant at the Imam Khomeini Hospital Complex from March 2018 to March 2019 and who were followed for 3 months after transplant. Acute kidney injury was defined based on the Acute Kidney Injury...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 15, 2021 Category: Transplant Surgery Authors: Reyhane Hizomi Arani Mohammad Reza Abbasi Mohammad Ali Mansournia Mohssen Nassiri Toosi Ali Jafarian Fatemeh Moosaie Elaheh Karimi Seyyed Saeed Moazzeni Zahra Abbasi Mohammad Hossein Shojamoradi Source Type: research

Association of Nephrectomy of the Failed Renal Allograft With Outcome of the Future Transplant: A Systematic Review
Exp Clin Transplant. 2021 Nov 11. doi: 10.6002/ect.2021.0133. Online ahead of print.ABSTRACTKidney allograft failure is a significant complication in kidney transplant recipients, and the surgical decision to perform allograft nephrectomy poses a strong dilemma because it is associated with significant morbidity and mortality. There is a debate over the effect of allograft nephrectomy on the development of allosensitization and the impact on potential retransplantation. Moreover, the use of immunosuppression may contribute to antibody allosensitization as allograft nephrectomy and immunosuppression act jointly and interdep...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 15, 2021 Category: Transplant Surgery Authors: Georgios Vlachopanos Mohsen El Kossi David Aziz Ahmed Halawa Source Type: research

COVID-19 Infection in Kidney Transplant Recipients From a Single Center in Iran
In this study, our aim was to evaluate the risk factors for increased mortality in deceased donor kidney transplant recipients with COVID-19 at a single center in Iran.MATERIALS AND METHODS: This was a retrospective study in a single center. During the 17-month ongoing COVID19 pandemic in Iran, there were 153 deceased donor kidney recipients at our center with suspected COVID19 symptoms. Of these patients, 138 had positive COVID-19 tests, and thus a therapeutic regimen was commenced for these patients. Data were analyzed with SPSS version 16 software.RESULTS: The patients were predominantly male (83, 60.1%) with a median a...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 15, 2021 Category: Transplant Surgery Authors: Maryam Rahbar Hormat Rahimzadeh Ziba Aghsaeifard Farzaneh Bagherpour Farshad Namdari Marzieh Latifi Hosein Dialameh Mohsen Taheri Mahmoudi Mona Niroumand Jalai Sanaz Dehghani Source Type: research

Discovery of a Rare Variant of the Arc of B ühler During Liver Procurement
We report a rare variant of the hepatic arterial supply observed during liver procurement from a 71-year-old female donor for whom an ischemic stroke caused brain death. Preoperative computed tomography showed a partially obliterated celiac trunk and an atypical arterial branch that coursed in a retropancreatic plane away from its origin at the superior mesenteric artery to anastomose with the common hepatic artery at the origin of the proper hepatic artery. The gastroduodenal artery and the dorsal pancreatic artery are the 2 conventional anastomotic arcades between the celiac trunk and the superior mesenteric artery. Howe...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 15, 2021 Category: Transplant Surgery Authors: Niccol ò Incarbone Riccardo De Carlis Leonardo Centonze Andrea Lauterio Luciano De Carlis Source Type: research

Safety and Efficacy of Kidney Transplants From Older Adult Living Donors: A Comparative Analysis of Donor and Recipient Outcomes
Exp Clin Transplant. 2021 Nov 11. doi: 10.6002/ect.2021.0246. Online ahead of print.ABSTRACTOBJECTIVES: We investigated the safety of donor nephrectomy from older adult donors (age ≥60 years), as well as long-term donor, recipient, and graft outcomes.MATERIALS AND METHODS: We retrospectively analyzed data from 307 living donor kidney transplants from 1996 to 2016 and defined 2 cohorts based on donor age. Cohort A comprised donors aged 60 years and older, and cohort B comprised donors from 18 to 59 years old. We recorded donor and recipient perioperative complications, outcomes, and survival rates and used SPSS and MedCa...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 15, 2021 Category: Transplant Surgery Authors: Abbas Ghazanfar Madiha Abbas Laylan Salih Joyce Popoola Ashar Wadoodi Sarah Heap Mysore Phanish Source Type: research

Role of Early Extubation After Orthotopic Liver Transplant
Exp Clin Transplant. 2021 Nov 11. doi: 10.6002/ect.2021.0281. Online ahead of print.NO ABSTRACTPMID:34775935 | DOI:10.6002/ect.2021.0281 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 15, 2021 Category: Transplant Surgery Authors: Benjamin Milne Source Type: research

Positive Association of Serum Adiponectin Level With the Vascular Reactivity Index in Kidney Transplant Patients
Exp Clin Transplant. 2021 Nov 11. doi: 10.6002/ect.2021.0253. Online ahead of print.ABSTRACTOBJECTIVES: Adiponectin has an important role in obesity, insulin resistance, and cardiovascular disease. We investigated the association between serum adiponectin levels and endothelial function in kidney transplant patients.MATERIALS AND METHODS: Fasting blood samples were obtained from 70 kidney transplant patients. The vascular reactivity index was measured with a digital thermal monitoring test. Serum adiponectin levels were measured with a commercially available enzyme immunoassay kit. A vascular reactivity index
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 15, 2021 Category: Transplant Surgery Authors: Wei-Chen Lin Ming-Che Lee Bang-Gee Hsu Source Type: research

Update on Vascular Complications After Renal Transplantation
Exp Clin Transplant. 2021 Nov 10. doi: 10.6002/ect.2021.0303. Online ahead of print.ABSTRACTRenal transplant is the treatment of choice for endstage renal failure. Since the first successful kidney transplant in 1954, advances in immunosuppression, surgical techniques, and posttransplant medical care have drastically improved the outcomes of this procedure. Despite these advances, surgical complications after renal transplant remain a challenge that can result in serious morbidity, graft loss, and recipient mortality. A significant proportion of surgical complications will have a vascular origin. Some of these vascular com...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 15, 2021 Category: Transplant Surgery Authors: Thilina Gunawardena Source Type: research

Risk Factors for Graft-Versus-Host Disease and Survival in Pediatric Hematopoietic Stem Cell Transplant Recipients: A Single-Center Experience
CONCLUSIONS: Although there are some known risk factors for graft-versus-host disease in adult patients, little is known about risk factors in children. In our comprehensive study in pediatric patients, we found that peripheral blood stem cell transplant, female-tomale transplant, and later neutrophil engraftment were associated with incidence of graft-versus-host disease. Although peripheral blood as a source of stem cells and female-to-male transplant are known risk factors, later neutrophil engraftment was a new finding as a possible risk factor for acute graft-versushost disease. This finding requires further verificat...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 15, 2021 Category: Transplant Surgery Authors: Tu ğba Bedir Demirdağ G özde Kurşun Ağlamiş Serap Kirkiz Kayal Asiye U ğraş Dikmen Z ühre Kaya İdil Yenicesu Ülker Koçak Source Type: research