Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Preconditioning Effect of Remifentanil Versus Fentanyl in Prevalence of Early Graft Dysfunction in Patients After Liver Transplant: A Randomized Clinical Trial.
CONCLUSIONS: We found that remifentanil and fentanyl were not different with regard to their preconditioning effects and graft protection in orthotopic liver transplant recipients. PMID: 32635883 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - July 6, 2020 Category: Transplant Surgery Authors: Jowkar S, Khosravi MB, Sahmeddini MA, Eghbal MH, Samadi K Tags: Exp Clin Transplant Source Type: research

Liver Transplant Due to Flupirtine-Induced Acute Liver Failure.
CONCLUSIONS: This is the largest published series of patients who received liver transplant after a drug-induced acute liver failure from flupirtine medication. PMID: 32635884 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - July 6, 2020 Category: Transplant Surgery Authors: Dondorf F, Croner RS, Tautenhahn HM, Felgendreff P, Ardelt M, Settmacher U, Rauchfuss F Tags: Exp Clin Transplant Source Type: research

Steroid-Sparing and Steroid-Based Immunosuppression in Kidney Transplant: Is There a Difference in Outcomes and Recipient Comorbidities?
Abstract OBJECTIVES: Corticosteroids are fundamental to immunosuppression in kidney transplant but have significant side effects, generating interest in steroid-sparing immunosuppression regimens. We studied corticosteroid withdrawal on graft outcomes and comorbidities to study individualized approaches for immunosuppression. This is the first study of its kind in our ethnically distinct population. MATERIALS AND METHODS: Of 103 consecutive Saudi kidney transplant recipients seen in our unit during 2014-2018, 102 passed screening; 32 received no oral steroids after immunosuppression induction (steroid-spared ...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - July 6, 2020 Category: Transplant Surgery Authors: Ahmad N, Khan TFT, Nadeem N, Fourtounas K Tags: Exp Clin Transplant Source Type: research

Obesity in Living-Donor Kidney Transplant: What Risks for the Donor and the Recipient?
Abstract For a kidney transplant candidate, a living-donor kidney transplant is the best option: it offers the longest survival to the recipient. Currently, more than 27000 living-donor kidney transplants are done each year in the world. More than 25% of all living kidney donors are now considered obese at the time of donation compared with fewer than 8% in the 1970s, and the proportion of obese recipients is doubling every 15 years as a result of the global epidemic of obesity. Obesity exposes both the donor and recipient to multiple complications: first, of an immediate surgical nature in the intra- and postoper...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - July 6, 2020 Category: Transplant Surgery Authors: Bentata Y Tags: Exp Clin Transplant Source Type: research

Update on the Management of BK Virus Infection.
Abstract The BK polyomavirus was isolated in 1971; it has been a significant risk factor for both graft dysfunction and failure in renal transplant recipients. So far, no specific treatment option has been available for effective treatment or prophylaxis for BK virus infections. Although the use of heavy immunosuppression has been the main risk factor for BK virus infection, other risk factors are equally important, including elderly recipients, prior rejection episodes, male sex, human leukocyte antigen mismatching, prolonged cold ischemia time, pretransplant BK virus serostatus, and ureteral stenting. Regular fo...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - June 16, 2020 Category: Transplant Surgery Authors: Saleh A, El Din Khedr MS, Ezzat A, Takou A, Halawa A Tags: Exp Clin Transplant Source Type: research

Rescue Hepatectomy and Anhepatic Phase Management After Primary Nonfunction in a Liver Transplant.
Abstract Primary nonfunction is a rare but lethal complication that occurs in a small number of liver transplants. When primary nonfunction occurs, the only definite treatment is retransplant; however, another liver might not be readily available at that time. Hence, a surgeon should be aware of the various options available at hand for patient care during the time interval between the primary nonfunction and retransplant. Here, we describe the management strategy that was devised to take care of an unstable anhepatic patient in the intensive care unit, care of the patient during anhepatic phase, and successful ou...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - June 16, 2020 Category: Transplant Surgery Authors: Singh N, Washburn K, Schenk A, Hill B, Hardy T, Black S, Sims C, Alebrahim M, El-Hinnawi A Tags: Exp Clin Transplant Source Type: research

A Prospective Study on Dissociative Experiences, Suicidal Ideation, and Predicting Factors During the Isolation Period of Hematopoietic Stem Cell Transplant.
Abstract OBJECTIVES: The aim of the present study was to investigate suicidal ideation and dissociative experiences and to predict demographic and clinical risk factors during isolation periods in patients undergoing hematopoietic stem cell transplant. MATERIALS AND METHODS: Our study included 61 consecutive stem cell recipients (29 autologous, 32 allogeneic). Patients were evaluated with the Suicidal Ideation Scale, Dissociative Experiences Scale, Hamilton Depression Scale, Hamilton Anxiety Scale, and State Trait Anxiety Inventory. RESULTS: The transplant procedure did not influence the Dissociative Exp...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - June 16, 2020 Category: Transplant Surgery Authors: Altintas E, Gereklioglu C, Gozukara Bag H, Boga C Tags: Exp Clin Transplant Source Type: research

Comparison of Coagulation Conditions in Patients With Liver Cirrhosis Due to Primary Sclerosing Cholangitis and Nonbiliary Causes of Cirrhosis Before Orthotopic Liver Transplant.
Abstract OBJECTIVES: Orthotopic liver transplant can be accompanied by an obscure bleeding pattern in patients with severe hepatic malfunction. In the present study, coagulation conditions of patients with cirrhosis of the liver due to primary sclerosing cholangitis and nonbiliary causes of cirrhosis were compared using rotational thromboelastometry assays obtained before orthotopic liver transplant. MATERIALS AND METHODS: This case control study analyzed patients who were candidates for orthotopic liver transplant from 2010 to 2016. Eighty patients with cirrhosis of the liver (40 patients with primary sclero...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - June 16, 2020 Category: Transplant Surgery Authors: Najafi A, Jafarian A, Makarem J, Barzin G, Salimi J, Nasiri-Toosi M, Moini M, Ebrahimi A, Behboudi B, Mohammadpour Z, Shariat Moharari R Tags: Exp Clin Transplant Source Type: research

Donor Age Amplifies the Detrimental Effects of Cold Ischemia Time on Long-Term Kidney Allograft Survival Independently of the Occurrence of Delayed Graft Function or Early Acute Rejection.
CONCLUSIONS: Allograft survival was negatively affected by donor age-cold ischemia time interaction independently of the development of delayed graft function, acute rejection, or their combination. PMID: 32552628 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - June 16, 2020 Category: Transplant Surgery Authors: Rincon Cintra da Cruz P, Cabral Dias Filho A, Santana VBBM, Biela Boaretto RB, Zanettini Riccetto CL Tags: Exp Clin Transplant Source Type: research

Successful Heart Transplant in a Childhood Cancer Survivor With Chemoradiotherapy-Induced Cardiomyopathy.
We describe herein a childhood cancer survivor after a cancer anamnesis with 2 different malignancies and an end-stage heart failure following chemoradiotherapy who was successfully treated with orthotopic heart transplant. PMID: 32552629 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - June 16, 2020 Category: Transplant Surgery Authors: Sipahi NF, Akhyari P, Aubin H, Mehdiani A, Erbel S, Westenfeld R, Scheiber D, Dalyanoglu H, Lichtenberg A, Boeken U Tags: Exp Clin Transplant Source Type: research

Comparison of the Success Rate of Two Different Marking Techniques (F-Mark and Asymmetric Triangular Mark) to Orient the Donor Graft During Descemet Membrane Endothelial Keratoplasty.
CONCLUSIONS: Although graft-marking techniques for Descemet membrane endothelial keratoplasty greatly facilitate graft positioning during surgery, both the potential toxic effects of alcohol on the endothelium when marking with gentian violet dye and the risk of graft detachment with asymmetric marking must be considered. PMID: 32552630 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - June 16, 2020 Category: Transplant Surgery Authors: Kandemir B, Tanyıldız B, Tutaş Günaydın N, Göktaş E Tags: Exp Clin Transplant Source Type: research

Sex and Gender Disparities in Pretransplant Characteristics and Relationships with Postoperative Outcomes in Liver Transplant Recipients with Alcoholic Liver Disease.
Abstract OBJECTIVES: Previous studies of liver transplant recipients have reported discrepancies with regard to gender and/or sex differences but have focused on pretransplant outcomes. Female candidates are less likely to receive liver transplant and more likely to die or be delisted than their male counterparts. Here, we examined differences in men versus women with alcoholic liver disease before liver transplant and the effects of these differences on posttransplant survival. MATERIALS AND METHODS: We analyzed the Scientific Registry of Transplant Recipients records of adult, deceased-donor, whole liver tr...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - June 16, 2020 Category: Transplant Surgery Authors: Matsuoka L, Izzy M, Feurer ID, Rega SA, Ziogas IA, Alexopoulos SP Tags: Exp Clin Transplant Source Type: research

Determining Channel Shift Cutoff in T-Cell and B-Cell Flow Cytometry Crossmatch.
PMID: 32490759 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - June 2, 2020 Category: Transplant Surgery Authors: Putheti P, Sharma VK Tags: Exp Clin Transplant Source Type: research

Laparoscopic Donor Nephrectomy Is a Safe Surgical Approach in Healthy Obese Kidney Donors: A 10-Year Single-Center Retrospective Study.
CONCLUSIONS: The laparoscopic approach for donor nephrectomy is a safe and effective method in obese donors without significant postoperative complications. PMID: 32490760 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - June 2, 2020 Category: Transplant Surgery Authors: Simforoosh N, Varyani M, Radfar MH, Aslani A, Honarkar Ramezani M, Farshid S, Bonakdar Hashemi M Tags: Exp Clin Transplant Source Type: research

Prevalence of BK Virus in Renal Transplant at a Single Center: Experience With Our Ureteral Reimplantation Surgical Technique.
CONCLUSIONS: Our type of ureteral stenting has a low rate of BK viruria and BK viremia compared with other studies. In addition, with our technique, the ureteral stent removal procedure does not require an invasive endoscopic procedure, thereby avoiding the consequent economic and assistance inconvenience typically associated with an endoscopic procedure. PMID: 32490761 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - June 2, 2020 Category: Transplant Surgery Authors: Martínez Moreno AI, Guimerà Garcia J, Riera Mari V, Pieras Ayala E Tags: Exp Clin Transplant Source Type: research

Use of Mycophenolate Mofetil Suspension as Part of Induction Therapy After Living-Donor Liver Transplant.
Abstract OBJECTIVES: The aim of this study was to evaluate recipient safety, tolerability, and pharmacokinetics of mycophenolate mofetil suspension compared with mycophenolate mofetil capsules as part of induction therapy after living-donor liver transplant. MATERIALS AND METHODS: Between July 2017 and April 2019, we retrospectively enrolled 20 adult primary living-donor liver transplant recipients. Recipients were divided into 3 groups: group 1 received mycophenolate mofetil suspension of 3000 mg (n = 6), group 2 received 3000 mg mycophenolate mofetil via opened capsules (n = 8), and group 3 received mycophe...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - June 2, 2020 Category: Transplant Surgery Authors: Harada N, Yoshizumi T, Yoshiya S, Takeishi K, Toshima T, Itoh S, Ikegami T, Fukuda M, Masuda S, Mori M Tags: Exp Clin Transplant Source Type: research

The Paradox of Increasing Waiting List Mortality and Declining Utilization of Deceased Donor Grafts in Kidney Transplant.
PMID: 32490764 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - June 2, 2020 Category: Transplant Surgery Authors: Moris D, Schmitz R, Dimitrokallis N, Schmidt T, Vernadakis S Tags: Exp Clin Transplant Source Type: research

Penetrating Keratoplasty With Sutureless Intrasclerally Fixated Intraocular Lens.
CONCLUSIONS: Penetrating keratoplasty with sutureless intrasclerally fixated intraocular lens implantation can be used safely in patients with aphakia. With this technique, the globe stabilization can be maintained, and the trauma to the donor graft endothelium can be minimized. PMID: 32490765 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - June 2, 2020 Category: Transplant Surgery Authors: Kasım B, Koçluk Y Tags: Exp Clin Transplant Source Type: research

Respiratory Complications Among Living Liver Donors: A Single-Center Retrospective Observational Study.
CONCLUSIONS: Despite the low incidence of significant respiratory complications among our living liver donor cohort, close monitoring and early management are essential to achieve better prognosis, especially in donors older than 35 years or those with previous surgery. PMID: 32370694 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - April 29, 2020 Category: Transplant Surgery Authors: Elbeialy MAK, Shorbagy MS, Saleh M, Elsaid K Tags: Exp Clin Transplant Source Type: research

Changes in Body Mass Index and Outcomes After Kidney Transplant: A Single-Center, Retrospective, Observational Study.
CONCLUSIONS: Our data demonstrated that body mass index was significantly reduced in the first month after kidney transplant before increasing to pretransplant levels during years 3 to 5. Furthermore, patients who retained decreased levels at 6 months had impaired graft function in long-term follow-up. These observations conflict with the existing literature and warrant further investigations. PMID: 32370695 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - April 29, 2020 Category: Transplant Surgery Authors: Sharif A, Arshad A, Hodson J, Khalil K Tags: Exp Clin Transplant Source Type: research

Risk Factors for Posttransplant Erythrocytosis: Parathyroid Hormone Paradox?
CONCLUSIONS: Persistent hyperparathyroidism and hypercalcemia could precipitate development of posttransplant erythrocytosis. The preserved residue renal function may be associated with increased endogenous erythropoietin, which could lead to posttransplant erythrocytosis development. PMID: 32370696 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - April 29, 2020 Category: Transplant Surgery Authors: Yeter HH, Fettahoglu F, Yesiloglu E, Akcay O, Korucu B, Bali M, Derici U Tags: Exp Clin Transplant Source Type: research

Predictors of Immediate Tracheal Extubation in the Operating Room After Pediatric Liver Transplantation.
CONCLUSIONS: About 46% of our pediatric orthotopic liver transplant recipients required mechanical ventilation postoperatively. Growth failure and higher intraoperative lactate levels were associated with need for postoperative mechanical ventilation. PMID: 32370697 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - April 29, 2020 Category: Transplant Surgery Authors: Ünlükaplan A, Torgay A, Pirat A, Arslan G, Haberal M Tags: Exp Clin Transplant Source Type: research

Percutaneous Management of Ureteral Obstructions and Leak After Renal Transplant.
CONCLUSIONS: Percutaneous management of ureteral complications is safe and effective and should be considered as first-line treatment because of its less invasive nature and lower complication and morbidity rates. PMID: 32370698 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - April 29, 2020 Category: Transplant Surgery Authors: Eldem FG, Akıncı D, Çiftçi T, Ünal E, Yıldırım T, Karabulut E, Aki FT, Akhan O Tags: Exp Clin Transplant Source Type: research

First Reported Cochlear Implantation in a Child with Total Artificial Heart.
We report a case of 15-year-old boy with postlingual bilateral total hearing loss following ototoxic medication during his pediatric intensive care unit stay. The patient received the SynCardia total artificial heart implant (50 mL; SynCardia Systems, Inc., Tucson, AZ, USA) for end-stage biventricular heart failure as a bridge to heart transplant. During his time on the urgent heart transplant wait list, he underwent successful cochlear implantation following optimized coagulation and hemostasis status and appropriate anesthetic preparation. Our case represents the world's first successful cochlear implant in a pediatric p...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - April 7, 2020 Category: Transplant Surgery Authors: Büyükatalay ZÇ, Agha Oghali AMN, Kendirli T, Can ÖS, Uçar T, Akar AR, Meço C Tags: Exp Clin Transplant Source Type: research

Methylprednisolone-Induced Hypersensitivity Reaction in a Liver Transplant Recipient.
Abstract Corticosteroids have an essential role as an immunosuppressive agent in transplant; because of their anti-inflammatory properties, they rarely cause an allergic reaction. Here, we report a liver transplant recipient who developed an allergic reaction to intravenous methylprednisolone sodium succinate. The deceased-donor orthotopic liver transplant recipient received intravenous methylprednisolone sodium succinate for induction during transplant, which was followed by another intravenous dose and oral prednisone taper. She was later treated with intravenous methylprednisolone sodium succinate taper for acu...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - April 7, 2020 Category: Transplant Surgery Authors: Szempruch KR, Vonderau JS, Desai CS Tags: Exp Clin Transplant Source Type: research

Efficacy of Antithymocyte Globulin Treatment for Severe Centrilobular Injury Following Pediatric Liver Transplant: Clinical Significance of Monitoring Lymphocyte Subset.
Abstract OBJECTIVES: Central perivenulitis can occur in association with T-cell-mediated rejection and can sometimes require strong immunosuppressant therapy as refractory rejection. Furthermore, patients with central perivenulitis are more likely to have subsequent episodes of T-cell-mediated rejection and develop chronic rejection than those without central perivenulitis. We retrospectively analyzed clinical data of pediatric patients with episodes of T-cell-mediated rejection according to severity of central perivenulitis and monitored HLA-DR-positive CD8-positive T cells and recent thymic emigrants during trea...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - April 7, 2020 Category: Transplant Surgery Authors: Uchida H, Sakamoto S, Shimizu S, Takeda M, Yanagi Y, Fukuda A, Uchiyama T, Irie R, Kasahara M Tags: Exp Clin Transplant Source Type: research

Transplantation in Ancient Greek Medicine.
PMID: 32281528 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - April 7, 2020 Category: Transplant Surgery Authors: Laios K, Kapolou V, Lytsikas-Sarlis P, Mavrommatis E, Tsakotos G, Tsoucalas G, Schizas D, Filippou D Tags: Exp Clin Transplant Source Type: research

Effects of Different Tacrolimus Doses on Adipose-Derived Stem Cells.
CONCLUSIONS: The dose of tacrolimus and the time of application of stem cells are important in the planning of stem cell therapy in organ transplant. PMID: 32281529 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - April 7, 2020 Category: Transplant Surgery Authors: Ertosun MG, Özkan Ö, Özkan Ö Tags: Exp Clin Transplant Source Type: research

Histologic Evaluations of Xenotransplanted Rabbit Knees by In Vitro-Propagated Human Amniotic Epithelial Cells: A Preclinical Study.
CONCLUSIONS: Human amniotic epithelial cells can be safely transplanted into knee joints, encouraging a need for complementary research for further therapeutic evaluations of human amniotic epithelial cells for curing arthritis. PMID: 32281530 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - April 7, 2020 Category: Transplant Surgery Authors: Dina EF, Nashwa RK, Nemr WA Tags: Exp Clin Transplant Source Type: research

Traumatic Neuroma and Liver Retransplant.
PMID: 32281531 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - April 7, 2020 Category: Transplant Surgery Authors: Mrzljak A, Skrtic A, Gasparov S, Kocman B, Jadrijevic S, Vuletic T, Budimir Bekan I, Mikulic D Tags: Exp Clin Transplant Source Type: research

Fabry Disease Screening in Patients With Kidney Transplant: A Single-Center Study in Turkey.
In this study, we investigated the use of screening for Fabry disease in kidney transplant recipients at our center. MATERIALS AND METHODS: We screened 301 kidney transplant recipients with functioning grafts. Analyses for α-galactosidase A gene mutation were performed in all female and male kidney transplant recipients. We also measured leukocyte α-galactosidase A enzyme activity in patients with identified GLA mutation. RESULTS: In 301 kidney transplant recipients, mean age was 42.9 ± 12.5 years, and the number of male patients was 180 (60%). Mean time after transplant was 79 ± 56 mont...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - April 7, 2020 Category: Transplant Surgery Authors: Erdogmus S, Kutlay S, Kumru G, Ors Sendogan D, Erturk S, Keven K, Ceylaner G, Sengul S Tags: Exp Clin Transplant Source Type: research

Use of Thromboelastography to Guide Platelet Infusion in a Patient with Wiskott-Aldrich Syndrome Undergoing Renal Transplant.
We describe the case of a 24-year-old male with Wiskott-Aldrich syndrome. The patient had previous hematopoietic stem cell transplant and was on hemodialysis due to end-stage renal failure. He subsequently underwent living-donor renal transplant from his mother as the donor. This is only the fifth case of renal transplant in a patient with Wiskott-Aldrich syndrome in the world. In all cases, the perioperative management of hemostatic function has been crucial. We used thromboelastography to guide our hemostatic decisions rather than platelet count, thus reducing exposure to unnecessary platelet transfusions and without inc...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - April 7, 2020 Category: Transplant Surgery Authors: Al Midani A, Donohue C, Berry P, Jones G, Fernando B Tags: Exp Clin Transplant Source Type: research

Protective Effect of HLA-E ∗0101∕∗0103 Genotype in Survival of Patients After Allogeneic Hematopoietic Stem Cell Transplant.
In this study, we evaluated the effects of different HLA-E genotypes on allogeneic hematopoietic stem cell transplant in southern Iran. MATERIALS AND METHODS: We investigated 200 patients (donors and recipients) who underwent allogeneic hematopoietic stem-cell transplant and 100 normal participants (control group) in a case-control study. Detection of HLA-E polymorphisms was performed using a sequence-specific primer polymerase chain reaction method. RESULTS: Statistical analyses indicated that genotypes in the transplant group were not distributed in accordance with Hardy-Weinberg equilibrium (χ²=76.56; P
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - April 7, 2020 Category: Transplant Surgery Authors: Mardani Valandani F, Ghorbani-Dalini S, Ramzi M, Aghababa H, Sarshar M, Haghgoo N, Azarpira N Tags: Exp Clin Transplant Source Type: research

Single-Center Experience of Recurrence Patterns and Survival Analyses of Patients With Hepatocellular Carcinoma and Liver Transplant.
CONCLUSIONS: Multidisciplinary treatment modalities, including surgery, interventional radiology techniques, and medical treatments, will probably lead to prolonged survival in patients with hepatocellular carcinoma. According to our center's expanded criteria, recurrence rates and time to recurrence were similar to those shown with the Milan group. We showed that Milan criteria can be safely expanded with promising results even in patients beyond Milan criteria. PMID: 32279656 [PubMed - in process] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - April 1, 2020 Category: Transplant Surgery Authors: Rahatli S, Ayvazoglu Soy EH, Oguz A, Altundag O, Moray G, Haberal M Tags: Exp Clin Transplant Source Type: research

Lung Transplant Patients Show a Dissimilar Peripheral B-Cell Subset Ratio Compared With Healthy Controls.
Abstract OBJECTIVES: Lung transplant is a last treatment option for patients with end-stage pulmonary disease. Chronic lung allograft dysfunction, which generally manifests as bronchiolitis obliterans syndrome, is a major long-term survival limitation. Bronchiolitis obliterans syndrome is diagnosed when forced expiratory volume in 1 second declines> 20% in the absence of known causes. B cells can either contribute or restrain the development of bronchiolitis obliterans syndrome (eg, via induction of alloimmune antibodies, regulation of cellular immunity, and induction of tolerance). Here, we explored how periph...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - April 1, 2020 Category: Transplant Surgery Authors: Schreurs I, Meek B, Hijdra D, Rodriguez Gomez M, van Moorsel CHM, Luijk HD, Kwakkel-van Erp JM, Oudijk EJ, van Kessel DA, Grutters JC Tags: Exp Clin Transplant Source Type: research

Machine Perfusion Decreases Delayed Graft Function in Donor Grafts With High Kidney Donor Profile Index.
CONCLUSIONS: Machine perfusion is beneficial in reducing delayed graft function only in donor kidneys with a higher risk profile. PMID: 32133939 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - March 4, 2020 Category: Transplant Surgery Authors: Montenovo MI, Perkins JD, Kling CE, Sibulesky L, Dick AA, Reyes JD Tags: Exp Clin Transplant Source Type: research

De Novo Malignancy After Heart, Kidney, and Liver Transplant: A Nationwide Study in Taiwan.
Abstract OBJECTIVES: In the Asian population, patterns and risk factors for de novo malignancies after solid-organ transplant are not well understood. MATERIALS AND METHODS: Insurance claims from Taiwan's National Health Institute Research Database from 1997 to 2011 revealed 687 deceased-donor heart transplant recipients, 5038 kidney transplant recipients (50% living related-donor, 50% deceased-donor transplants), and 2127 liver transplant recipients (mainly living related-donor transplants, 30% deceased-donor transplants). During the follow-up period, rates of malignancy incidence were calculated with standa...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - March 4, 2020 Category: Transplant Surgery Authors: Yeh CC, Khan A, Muo CH, Yang HR, Li PC, Chang CH, Chen TL, Jeng LB, Liao CC Tags: Exp Clin Transplant Source Type: research

Outcomes After Direct-Acting Antiviral Therapy Based on Donor Hepatitis C Serostatus Among Hepatitis C Virus-Infected Kidney Transplant Recipients.
Abstract OBJECTIVES: Renal grafts from hepatitis C virus-positive deceased donors, which were once discarded, can now be transplanted into recipients and treated posttransplant due to the emergence of direct-acting antivirals, significantly improving wait list time and organ shortages. Here, we compared outcomes in hepatitis C virus-positive patients who received kidneys from hepatitis C virus-positive versus -negative donors. MATERIALS AND METHODS: In this single-center retrospective study, we divided 52 kidney transplant recipients who were viremic for hepatitis C virus pretransplant into 2 groups based on ...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - March 4, 2020 Category: Transplant Surgery Authors: Sedki M, Cortesi C, O'Brien C, Levy C, Martin P, Roth D, Bhamidimarri KR Tags: Exp Clin Transplant Source Type: research

Role of Synthetic Mesh Renorrhaphy and Neocapsule Reconstruction to Salvage Posttransplant Severely Damaged Renal Allografts.
CONCLUSIONS: This simple technique using readily available materials can salvage allografts that would have been potentially explanted or discarded. PMID: 32133942 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - March 4, 2020 Category: Transplant Surgery Authors: Garcher D, Ekwenna O, Ortiz J, Rees M, Selman S, Sindhwani P Tags: Exp Clin Transplant Source Type: research

Factors Associated With Length of Hospital Stay Following Liver Transplant Surgery.
Abstract OBJECTIVES: Length of stay is considered an important surrogate for transplant survival rate and resource utilization. Therefore, in the present study, our aim was to determine factors affecting length of hospital stay. MATERIALS AND METHODS: We retrospectively analyzed records of patients who underwent liver transplant at the Tehran University of Medical Sciences Liver Transplantation Center from March 2014 to March 2016. RESULTS: For our final analyses, there were 161 adult recipients, including 106 males (65.8%) and 55 females (34.1%). Univariate analyses showed that body mass index, Modelfor...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - March 4, 2020 Category: Transplant Surgery Authors: Amiri M, Toosi MN, Moazzami B, Jafarian A, Shahsavari H, Javaherian M, Dashti H, Fakhar N, Karimi M, Khani F Tags: Exp Clin Transplant Source Type: research

Rapidly Progressive Pulmonary Kaposi Sarcoma After Bilateral Sequential Lung Transplant: A Case Report.
In this study, we present a case of Kaposi sarcoma in a 58-year-old patient diagnosed at 8 months after bilateral sequential lung transplant due to chronic obstructive pulmonary disease. Kaposi sarcoma showed rapid progression despite immunosuppressive drug modification, resulting in lung involvement and respiratory failure. Rapid and complete improvement was achieved with rapid diagnosis and aggressive treatment that included combined chemotherapy after surgery. The patient presented with no complications from Kaposi sarcoma at month 26 after transplant. PMID: 32133944 [PubMed - as supplied by publisher] (Source: Exp...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - March 4, 2020 Category: Transplant Surgery Authors: Turkkan S, Subasi M, Celik Basaran F, Sahin MF, Yazicioglu A, Demirag F, Yekeler E Tags: Exp Clin Transplant Source Type: research

Endovascular Treatment of Acute Posttransplant Portal Vein Thrombosis Due to Portal Steal From Mesocaval And Coronary Portosystemic Shunts.
Abstract The management of portosystemic shunts in liver transplant recipients relies on appropriate perioperative study. There are several strategies for shunt handling, ranging from preoperative interventional procedures to intraoperative surgical interruption or embolization. Appropriate management often results in a successful outcome, although wrong decisions could lead to serious consequences. Here, we report a liver transplant recipient with grade 2 portal vein thrombosis associated with 2 large portosystemic shunts (coronary and mesocaval), which were managed intraoperatively via thrombectomy without shunt...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 7, 2020 Category: Transplant Surgery Authors: Centonze L, Di Sandro S, Cereda M, Lauterio A, De Carlis R, Migliorisi C, Morelli F, Rampoldi A, De Carlis L Tags: Exp Clin Transplant Source Type: research

Efficacy of Posttransplant Ledipasvir-Sofosbuvir in the Treatment of Patients Who Have Undergone Chronic Hepatitis C-Related Liver Transplant.
This study investigated the efficacy of ledipasvir-sofosbuvir, a newly developed direct-acting antiviral drug combination for hepatitis C virus infection recurrence in patients who have developed cirrhosis secondary to hepatitis C virus and who have undergone liver transplant. MATERIALS AND METHODS: We retrospectively analyzed 27 patients who underwent liver transplant due to hepatitis C virus-related cirrhosis and who received ledipasvir-sofosbuvirfor 12 weeks between January 1, 2016 and December 31, 2017 following transplant procedures conducted at the Inonu University Turgut Ozal Medical Center Gastroenterology Dep...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 7, 2020 Category: Transplant Surgery Authors: Kandemir MH, Aladag M, Cagin YF, Yildirim HE, Sarici A Tags: Exp Clin Transplant Source Type: research

A Single-Center Experience With Third and Fourth Kidney Transplants and Second Kidney Transplant After Pancreas-Kidney Transplant: Surgical Aspects and Outcomes.
CONCLUSIONS: Retransplant of a second graft after pancreas-kidney transplant or retransplant of a third or fourth renal graft is challenging but feasible, with evidence of reasonably positive outcomes after retransplant. PMID: 32039668 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 7, 2020 Category: Transplant Surgery Authors: Salguero Segura J, Valero Rosa J, Gomez E, Navarro Cabello MD, Ruiz Garcia J, Rodriguez Benot A, Robles Garcia JE, Requena Tapia MJ, Campos Hernández JP Tags: Exp Clin Transplant Source Type: research

Hepatic Resection and Transplant in Glycogen Storage Diseases.
Abstract Patients with glycogen storage diseases pose unique management challenges to clinicians.These challenges are exacerbated wheneverthey undergo surgery as the basic anomaly in their glycogen storage pathways make them susceptible to organic acidosis, which may in turn complicate their preoperative, intraoperative, and postoperative course. Because of the rarity of these diseases, clinicians may not be aware of the specific management concerns. In the case reported here, a 37-year-old patient with glycogen storage disease type 1 underwentleft hepatectomy for hepatic adenomatosis, which was complicated by int...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 7, 2020 Category: Transplant Surgery Authors: Singh N, El-Hinnawi A, Hill B, Elkhammas E, Eze O, Alebrahim M, Michaels A, Schenk A, Washburn K, Black S Tags: Exp Clin Transplant Source Type: research

Intervention on Spontaneous Splenorenal Shunt May Decrease the Incidence of Acute Kidney Injury After Liver Transplant.
CONCLUSIONS: Peritransplant interventions for spontaneous splenorenal shunt may reduce posttransplant acute kidney injury. In patients without intervention, spontaneous splenorenal shunt predominantly persisted 1 year posttransplant. PMID: 32039670 [PubMed - as supplied by publisher] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 7, 2020 Category: Transplant Surgery Authors: Nickkholgh A, Wang J, Shahbazov R, Pelletier S, Maluf D Tags: Exp Clin Transplant Source Type: research

New Markers for Transplant Rejection.
Abstract Monitoring allograft function after kidney transplant has routinely relied on the use of nonspecific markers, such as serum creatinine, glomerular filtration rate, proteinuria, and donor-specific antibodies. These traditional markers have low sensitivity and fail to detect subclinical changes. Diagnosis of renal allograft dysfunction still requires an allograft biopsy, as it remains the criterion standard for assessment of graft status. However, renal biopsy is an invasive procedure, and sampling errors may result in misdiagnosis, perhaps causing graft failure. New biomarkers have been developed to monito...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - January 1, 2020 Category: Transplant Surgery Authors: Argani H Tags: Exp Clin Transplant Source Type: research

Technical Challenges and Innovations in Kidney Transplantation: Experience With Over 5000 Cases.
In this report, we present our approach for the following scenarios: transplant in patients with urinary diversion and augmentation, polycystic disease in recipients, tumors in transplanted kidney and native kidneys, and the roles of laparoscopy and mini-laparoscopy in kidney transplant. PMID: 32008485 [PubMed - in process] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - January 1, 2020 Category: Transplant Surgery Authors: Simforoosh N, Basiri A, Tabibi A, Nadjafi-Semnani M Tags: Exp Clin Transplant Source Type: research

Ways to Overcome Organ Shortage: Increasing Donor Pool by Accepting Suboptimal Kidney Donors.
Abstract Many factors affect organ donations worldwide, including religious factors, legislative decisions, economic factors, presence of organ procurement organizations, cultural issues, the presence of commercial transplant, and other unknown factors. The number of patients with end-stage renal disease has increased by 6% worldwide. Even with more transplant procedures, these numbers have not combated the dramatically increased number of patients on wait lists. With regard to potential living donors, around 50% are either blood group or HLA incompatible with the recipient, which then requires patient desensitiza...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - January 1, 2020 Category: Transplant Surgery Authors: Shaheen FAM, Kurpad R, Shaheen MF, Al Sayyari A Tags: Exp Clin Transplant Source Type: research

How Did the War Affect Organ Transplantation in Syria?
Abstract Since 2011, the Syrian conflict has destroyed much of the country's infrastructure. The deteriorating humanitarian situation has involved health workers and facilities. In 2010, before the war, 385 kidney transplants were performed in Syria. This number declined to 154 in 2013 (60% less) before increasing to 251 transplants in 2018, which is still 35% less than the number of transplants performed before the war. In addition, the number of operational kidney transplant centers has decreased from 8 in 2010, distributed over 3 cities, to only 4 in 2013, all located in Damascus, which increased to 6 centers i...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - January 1, 2020 Category: Transplant Surgery Authors: Saeed B Tags: Exp Clin Transplant Source Type: research