Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Interaction Between Tacrolimus and Proton Pump Inhibitor in a Kidney Transplant Recipient
Exp Clin Transplant. 2024 Jan;22(Suppl 1):354-355. doi: 10.6002/ect.MESOT2023.P89.ABSTRACTWe aimed to present a drug monitoring profile of tacrolimus and proton pump inhibitor coadministration in a 23-year-old male patient with a history of high blood pressure who underwent kidney transplant. The patient's serum trough levels of tacrolimus were in the therapeutic range until omeprazole 20 mg daily was prescribed. Tacrolimus trough serum level increased to 29.5 ng/mL under the same daily dose and to 13.9 ng/mL after tacrolimus daily dose was decreased to 6 mg/day. This increase in tacrolimus serum level was behind a renal f...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Khouloud Ferchichi Syrine Ben Hammamia Mouna Ben Sassi Hanene El Jebari Rim Charfi Riadh Daghfous Emna Gaies Sameh Trabelsi Source Type: research

Drug-Drug Interaction between Tacrolimus and Fluconazole in a Kidney Transplant Recipient
We report a case of tacrolimus and fluconazole drug-drug interaction in a 20-year-old female kidney transplant recipient with stable kidney function. The patient's tacrolimus blood concentrations were in the therapeutic range until fluconazole was administrated for Candida albicans infection, on day 58 posttransplant. Tacrolimus blood concentration increased by 125% (18.4 ng/mL) on day 79 and by 212% (25.4 ng/mL) on day 84 posttransplant. On day 92, tacrolimus trough blood concentration returned to the therapeutic range (5.6 ng/mL), with decrease of tacrolimus daily dose by 50% (to 4 mg). After fluconazole withdrawal, the ...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Khouloud Ferchichi Syrine Ben Hammamia Mouna Ben Sassi Hanene El Jebari Rim Charfi Riadh Daghfous Emna Gaies Sameh Trabelsi Source Type: research

A Different Perspective on the COVID-19 Pandemic: Origin of the Outbreak (Part 1)
Exp Clin Transplant. 2024 Jan;22(Suppl 2):1-14. doi: 10.6002/ect.2023.0074.ABSTRACTIn December 2019, an outbreak caused by novel coronavirus 2019 (COVID-19) started in Wuhan, China. After extensive speculation about a causative agent, a novel betacoronavirus, in the same family as SARS-CoV and MERS-CoV, was identified via next-generation sequencing from samples received from several pneumonia patients. Ribonucleic acid extracted from the patient's bronchoalveolar lavage fluid was used as a template to clone and sequence the genome of SARS-CoV-2. Shortly after, the World Health Organization announced a worldwide pandemic. H...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Antoine Barbari Source Type: research

A Different Perspective on the COVID-19 Pandemic: Validity of COVID-19 Testing and Protective Nonpharmaceutical Interventions (Part 2)
Exp Clin Transplant. 2024 Jan;22(Suppl 2):15-32. doi: 10.6002/ect.2023.0130.ABSTRACTThe causative agent for COVID-19 was identified by next-generation sequencing from samples received from several pneumonia patients. The detection of the coronavirus was done through real-time polymerase chain reaction analyses performed from plasma sample. Ribonucleic acid extracted from a patient's bronchoalveolar lavage fluid was used as a template to clone and sequence a genome from lineage B of the betacoronavirus. A polymerase chain reaction test was considered positive using cycle threshold above 34 for detected samples. Tests with t...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Antoine Barbari Source Type: research

A Different Perspective of COVID-19 Pandemic: Efficacy and Safety of mRNA Vaccines in Immunocompetent and Immunocompromised Individuals (Part 3)
Exp Clin Transplant. 2024 Jan;22(Suppl 2):33-62. doi: 10.6002/ect.2023.0132.ABSTRACTShortly after the declaration of the pandemic, several anti-SARS-CoV-2 vaccines entered phase 3 clinical trials. One year later, Pfizer-BioNTech and Moderna published their initial trial results, encompassing a 2-month follow-up. The studies were only designed to test whether the vaccines were effective and safe on the short-term.The vaccine's efficacy in the 2 trials was defined as relative risk reduction instead of absolute risk reduction, a more accurate determinant of vaccine effectiveness in the real world. These studies were not desig...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Antoine Barbari Source Type: research

Therapeutic Plasma Exchange in Children With Acute and Acuteon-Chronic Liver Failure: A Single-Center Experience
CONCLUSIONS: Therapeutic plasma exchange may assist bridge to liver transplant or assist with spontaneous recovery of liver failure in pediatric patients with acute liver failure or acute-on-chronic liver failure.PMID:38385381 | DOI:10.6002/ect.MESOT2023.O12 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Sad ık Kaya Neslihan Ek şi Bozbulut Source Type: research

Evaluation of Imaging Findings in Patients with Pretransplant and Posttransplant Tertiary Hyperparathyroidism
CONCLUSIONS: Higher numbers of detectable glands and the presence of parathyroid autonomy were more common in the pretransplant group. This might be explained by parathyroid gland involution after transplant. The results may also suggest that factors other than autonomy are responsible for posttransplant tertiary hyperparathyroidism.PMID:38385382 | DOI:10.6002/ect.MESOT2023.O16 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Ay şe Aktaş Esra Arzu Gen çoğlu Turan Çolak Kemal Murat Haberal Binnaz Handan Özdemir Cihat Burak Sayin Mehmet Haberal Source Type: research

An Alternative and Up-To-Date Recommendation for a Proper Site for Parathyroid Transplantation: The Omentum
CONCLUSIONS: In the 23 patients, the success rate was 69.5% for the first 6-month period after transplant. Recent developments and large cohorts are needed to demonstrate the higher efficacy of parathyroid allotransplant over the omentum.PMID:38385383 | DOI:10.6002/ect.MESOT2023.O17 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Yeliz Emine Ersoy Beyza Goncu Emrah Yucesan Harika Salepcioglu Kaya Rumeyza Kazancioglu Adem Akcakaya Source Type: research

Delayed Graft Function in Pediatric Kidney Transplant: Risk Factors and Outcomes
CONCLUSIONS: Delayed graft function is a major determinant of early graft function and allograft rejection-free survival. Further research is required to establish proper preventive measures.PMID:38385384 | DOI:10.6002/ect.MESOT2023.O20 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Abir Boussetta Nesrine Abida Manel Jellouli Jalel Ziadi Tahar Gargah Source Type: research

Efficacy of mTOR Inhibitors and Intravenous Immunoglobulin for Treatment of Polyoma BK Nephropathy in Kidney Transplant Recipients: A Biopsy-Proven Study
CONCLUSIONS: In patients with polyoma BK virus nephropathy, clearance of viremia and SV40 should not be the sole outcomes to obtain. Aggressive reductions in maintenance immunosuppression and switching to double-drug therapy combined with high-dose intravenous immunoglobulin leads to high rates of graft loss/rejection and sequalae of chronic histological changes.PMID:38385385 | DOI:10.6002/ect.MESOT2023.O29 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Murat Karatas Erhan Tatar Gokalp Okut Ali Murat Yildirim Emre Kocabas Funda Tasli Alkan Cenk Simsek Sait Murat Dogan Adam Uslu Source Type: research

Effect of Repeated Structured Diabetes Education on Lifestyle Knowledge and Self-Care Diabetes Management in Kidney Transplant Patients With Posttransplant Diabetes
CONCLUSIONS: Structured diabetes education improved lifestyle knowledge, self-care diabetes management, and metabolic control variables among kidney transplant recipients with posttransplant diabetes. Structured diabetes education also resulted in partial reversibility of the present early diabetic nephropathy. We recommended such education to be delivered to all kidney transplant recipients with diabetes.PMID:38385386 | DOI:10.6002/ect.MESOT2023.O31 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Nashwa Othman Torki Al-Otaibi Medhat A Halim Tarek Said Nabil Elserwy Fatma Mahmoud Heba Abduo Mohamed Jahromi Narayanan Nampoory Osama Ashry Gheith Source Type: research

Ocular Symptoms in Kidney, Liver, and Heart Transplant Patients
CONCLUSIONS: Ocular findings were seen in most of the kidney and liver transplant recipients. Therefore, it is required that these patients undergo routine ocular screenings in order to facilitate early diagnosis and prompt treatment when needed.PMID:38385387 | DOI:10.6002/ect.MESOT2023.O34 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Almila Sarigul Sezenoz Gulsah Gokgoz Irem Kirci Dogan Sirel Gur Gungor Sibel Oto Mehmet Haberal Source Type: research

Predicting Mortality of COVID-19 in Kidney Transplant Recipients With Developed Scores
CONCLUSIONS: Kidney and other solid-organ transplant patients are at greater risk of infection and mortality than other groups. Accurate risk-predicting tools are imperative for managing the COVID-19 pandemic with limited health resources.PMID:38385388 | DOI:10.6002/ect.MESOT2023.O35 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Gulsah Sasak Kuzgun Sabahat Alisir Ecder Tahsin Karaaslan Gozde Turkel Zhala Ayalaoglu Source Type: research

An Emerging Issue: Carbapenem-Resistant Enterobacteriaceae in Solid-Organ Transplantation
CONCLUSIONS: Carbapenem resistance increased significantly over the years. Bacteremia 48 hours after hospitalization and hospitalization within the past 3 months were determined to be risk factors for carbapenem resistance. Carbapenem-resistant infections are still nosocomial infections. Patients should be hospitalized for as a short time as possible, and both patients and their physicians should follow infection control and prevention methods.PMID:38385389 | DOI:10.6002/ect.MESOT2023.O38 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Tu ğba Yanık Yalçın Nuran Sar ı Çağla Sarıkaş Çiğdem Erol Özlem Azap Hande Arslan Mehmet Haberal Source Type: research

Evaluation of Candidemia in Solid-Organ Transplant Recipients
CONCLUSIONS: For adult solid-organ transplant recipients with candidemia, careful monitoring is essential for successful management of total parenteral nutrition, central catheter, use of broadspectrum antibiotics, and invasive interventions.PMID:38385390 | DOI:10.6002/ect.MESOT2023.O39 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Nuran Sari Tu ğba Yanik Yalçin Çiğdem Erol Özlem Kurt Azap Hande Arslan Emre Karakaya Atilla Sezgin Mehmet Haberal Source Type: research