Preparation of Diphtheria and Pseudomonas Exotoxin A Immunotoxins and Evaluation of Their Cytotoxicity Effect on SK-BR-3, BT-474, and MDA-MB-231 Breast Cancer Cell Lines.
In this study, we introduce immunotoxins comprising of truncated pseudomonas exotoxin A (PEA) and diphtheria toxin (DT) conjugated to trastuzumab. The effectiveness of 20 and 30 μg/ml immunotoxins and trastuzumab were studied on SK-BR-3 and BT-474 HER2/neu positive breast cancer cell lines by a cell death assay test. The produced immunotoxins have the potential to reduce the therapeutic dose of the trastuzumab and in the same time achieve higher efficiency. PMID: 31597492 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - October 11, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Oncological Outcome After Radical Prostatectomy without Pelvic Lymph Node Dissection for Localized Prostate Cancer: Follow-up Results in a Single Institution.
In this study, we reported oncological outcome in consecutive 146 patients who underwent RP without PLND. Although 27% of our patients developed biochemical recurrence, the estimated 5-year overall survival rates were 100%, 96.3%, and 95.7% in the low-, intermediate-, and high-risk groups, respectively. These data in our patients were not inferior to those in previous reports that investigated the survivals in patients who received PLND during RP. The therapeutic significance of PLND should be re-evaluated. PMID: 31597501 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - October 11, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Leptomeningeal Metastases in Renal Cell Carcinoma at Initial Diagnosis: 2 Case Reports and Literature Review.
Authors: Dridi M, Bouleftour W, Rivoirard R, Dal Col P, Langrand-Escure J, Vassal C, Guillot A Abstract Leptomeningeal metastasis (LM) in solid tumors are rare, even more in renal cell carcinoma (RCC). To date there is a lack of consensual treatment modalities of leptomeningeal metastasis. Furthermore, with the improvement of outcomes and more effective systemic targeted therapies, the management of leptomeningeal metastasis becomes a real challenge. We here report two cases of RCC with leptomeningeal metastasis at initial diagnosis. Both patients had concurrent adjacent skull bone metastasis. Therapeutic managemen...
Source: Cancer Investigation - October 5, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Identifying Similarities and Disparities between DNA Copy Number Changes in Cancer and Matched Blood Samples.
Conclusions: The results showed that a few chromosomes have a large number of MICs exceeding a high threshold. These locations can potentially be used to identify early indicators of NSCLC. In contrast, second group of chromosomes have several locations with small MICs which are potential candidates to develop biomarkers for discriminating cancer from the matched blood sample. Moreover, there is a third group of chromosomes with a large number of MICs exceeding a high threshold and a large set of MICs below a low threshold. These locations can help with both finding early indicators of cancer and developing biomarkers for ...
Source: Cancer Investigation - October 5, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Increased Risk of Hypertension with Enzalutamide in Prostate Cancer: a Meta-Analysis.
Authors: Zhu X, Wu S Abstract Hypertension is associated with enzalutamide in the treatment of prostate cancer. We performed a meta-analysis of randomized clinical trials to determine the risk of hypertension. Databases including Pubmed and Google scholar were searched to identify randomized clinical trials with enzalutamide. A total of seven studies including 7,347 patients were selected. The overall incidences of all-grade and high-grade hypertension were 11.9% (95%% CI: 8.8-16.0%) and 4.9% (95%% CI: 3.5-6.8%) respectively, with a relative risk of 2.82 (95%% CI: 2.34-3.38, P 
Source: Cancer Investigation - September 28, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers.
Authors: Záveský L, Jandáková E, Weinberger V, Minář L, Hanzíková V, Dušková D, Drábková LZ, Hořínek A Abstract Ovarian cancer is the deadliest gynecologic cancer. The large-scale microRNA (miRNA) expression profiling and individual miRNA validation was performed to find potential novel biomarkers for ovarian cancer. The most consistent overexpression of miRs-200b-3p, 135 b-5p and 182-5p was found in both ascitic fluid and tumors and suggests their potential as oncogenes. miR-451a was consistently underexpressed so may be a...
Source: Cancer Investigation - September 20, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Socioeconomic Factors Associated with Lack of Treatment in Early Stage Non-Small Cell Lung Cancer.
Authors: Dalwadi SM, Zhang J, Bernicker EH, Butler EB, Teh BS, Farach AM Abstract With modern radiotherapy, stage I non-small cell lung cancer (S1NSCLC) cure is extended to nonsurgical candidates. Despite this, some S1NSCLC remains untreated. We aim to identify factors associated with no treatment. 62,213 S1NSCLC cases were identified (SEER: 2004-2012). Demographics were compared using Chi-squared. Multivariate analysis was performed using COX proportional HR. 11.9% of the 7373 patients lacked treatment. No insurance, Medicaid-dependence, unmarried status, advancing age, lower income, African American and Asian/Pac...
Source: Cancer Investigation - September 20, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Circulating Cell Free Nuclear DNA, Mitochondrial DNA and Global DNA Methylation: Potential Noninvasive Biomarkers for Breast Cancer Diagnosis.
Authors: Pasha HA, Rezk NA, Riad MA Abstract Eighty seven women with benign breast lesion, 120 patients with breast cancer (BC) and one hundred controls were included in the study. Quantification of mtDNA and nDNA was done by qPCR. Global DNA methylation was measured using ELISA. Circulating cell-free nDNA and mtDNA were significantly elevated in BC and benign breast lesions patients. Global methylation was significantly low in BC patients. Combining the studied parameters in one panel, nDNA/mtDNA/hypomethylation, improved their sensitivity in detecting BC to reach 92.5%. Circulating cell-free nDNA, mtDNA and globa...
Source: Cancer Investigation - September 14, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Effect of Imipramine on radiosensitivity of Prostate Cancer: An In Vitro Study.
This study was performed to investigate the radiosensitizing effect of IMI on DU145 prostate cancer cell. Cells were divided into 4 groups. Cell index, apoptotic activity, cell cycle arrest, oxidative stress and EAG1 channel currents were determined in all groups. Our findings showed that combined treatment with IMI and radiotherapy (RAD) did not enhance radiosensitivity of DU145 cells but as unexpected finding, treatment of IMI alone was more effective in DU145 cells. PMID: 31496302 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - September 11, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Rumors of the Death of Biosimilars Have Been Greatly Exaggerated.
Authors: Lyman GH, Kuderer NM PMID: 31500458 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - September 11, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Virotherapy: Current Trends and Future Prospects for Treatment of Colon and Rectal Malignancies.
Authors: Lee CL, Veeramani S, Molouki A, Lim SHE, Thomas W, Chia SL, Yusoff K Abstract Colorectal cancer (CRC) is one of the most common malignancies. In recent decades, early diagnosis and conventional therapies have resulted in a significant reduction in mortality. However, late stage metastatic disease still has very limited effective treatment options. There is a growing interest in using viruses to help target therapies to tumour sites. In recent years the evolution of immunotherapy has emphasised the importance of directing the immune system to eliminate tumour cells; we aim to give a state-of-the-art over-vi...
Source: Cancer Investigation - September 11, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Clinical significance of tumor-infiltrating T cells and programmed death ligand-1 in patients with pancreatic cancer.
Authors: Yoshida S, Ito Z, Suka M, Bito T, Kan S, Akasu T, Saruta M, Okamoto M, Kitamura H, Fujioka S, Misawa T, Akiba T, Yanagisawa H, Sugiyama H, Koido S Abstract The associations of the immunological status of the pancreatic ductal adenocarcinoma (PDA) microenvironment with prognosis were assessed. A high tumor-infiltrating lymphocyte (TIL) density was associated with a better prognosis. Importantly, even with a high density of TILs, the PDA cells with programmed cell death-ligand 1 (PD-L1) expression showed a worse prognosis than the patients with negative PD-L1 expression. A significant association between a b...
Source: Cancer Investigation - September 8, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Gastric mucosal microarchitectures associated with irreversibility with Helicobacter pylori eradication and downregulation of micro RNA (miR)-124a.
Authors: Tahara T, Tahara S, Horiguchi N, Kawamura T, Okubo M, Nagasaka M, Nakagawa Y, Shibata T, Urano M, Tsukamoto T, Kuroda M, Ohmiya N Abstract To investigate the molecular mechanisms of gastric carcinogenesis after Helicobacter pylori (H. pylori) eradication, expression of miR-124a, miR-34b, and miR-34c was examined in nonneoplastic gastric specimens after successful H. pylori eradication. The magnifying narrow-band imaging (NBI) endoscopic features of gastric mucosa were also examined. The atrophic type, an informative endoscopic feature for histological intestinal metaplasia, showed lower expression of miR-1...
Source: Cancer Investigation - September 5, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

The Role of Additional Chemotherapy in Combination with Concurrent Chemoradiotherapy for Locally Advanced Inoperable Non-Small Cell Lung Cancer, a Systematic Review and Meta-Analysis of 12 Randomized Trials.
Authors: Ying M, Liu J, Zhou W, Weng K, Long B, Wang Y Abstract This meta-analysis aims to evaluate the effectiveness of chemotherapy before (I-CRT) or after (CRT-C) chemoradiotherapy (CRT) for inoperable locally advanced non-small cell lung cancer (LA-NSCLC). According to the object response rate (ORR) and disease control rate (DCR), there were no differences among I-CRT, CRT, and CRT-C treatments. I-CRT did not have significant survival benefits compared with CRT alone. Similar results comparing CRT-C with CRT were observed. Furthermore, I-CRT was not associated with improved survival compared to CRT-C with respe...
Source: Cancer Investigation - September 4, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Radiotherapy in the treatment of primary or recurrent unresectable desmoid tumors of the neck.
Conclusion: Radiotherapy is a valuable option in the management of primary or recurrent unresectable DTs of the neck with good local control. Multi-institutional and prospective studies are warranted to further validate our findings. PMID: 31474159 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - September 4, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Non-viral parasites associated with Carcinogenesis.
Authors: Jain S, Sengupta M, Jain P Abstract Cancer is a proficient evader of the immune system and is responsible for a high number of deaths annually. Most of these cancer cases are associated with genetic mutations, viruses, radiations or other carcinogenic substances like tobacco smoke. However, a significant number of cases arise as a result of infection by certain parasitic organisms other than viruses. This review tries to explore various less studied mechanisms by which these parasites induce cancer and lead to its progression. The changes brought by organisms in the genetic makeup are enumerated along with...
Source: Cancer Investigation - September 1, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Aryl Hydrocarbon Receptor Mediates Cell Proliferation Enhanced by Benzo[a]pyrene in Human Lung Cancer 3D Spheroids.
In this study, we analyzed the effects of B[a]P and AhR in the 3 D spheroids of human lung cancer cells in vitro. In these spheroids, B[a]P and AhR enhanced cancer cell proliferation. These results suggest that the AhR-dependent effects of B[a]P on cell proliferation may contribute to the adverse effects of continuous smoking with respect to lung cancer malignancy. PMID: 31462083 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - August 31, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Prospects and problems of cancer genome analysis for establishing cancer precision medicine.
Authors: Hayashi T, Konishi I Abstract The genome represents a design for creating the body, with each one being different. In cancer genomic medicine, many genes are simultaneously examined using mainly cancer tissues (the oncogene panel test), and gene mutations are revealed. Cancer treatments are then initiated according to each individual's constitution and medical condition based on gene mutations. A system for cancer genome medical treatment is currently being developed. In the treatment of several cancer types, the "oncogene test with an oncogene companion diagnosis" is already being performed as a...
Source: Cancer Investigation - August 29, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Aspirin Use and Risk of Ovarian Cancer: More Player Pathways for a Common Starting Point?
Authors: Mormile R PMID: 31446811 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - August 28, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Trends in Survival Based on Treatment Modality in Non-Small Cell Lung Cancer Patients: A Population-Based Study.
We examined the trends in survival based on treatment modality among non-small cell lung cancer (NSCLC) patients in the province of Ontario, Canada, from 2007 to 2015. Methods: We investigated the trends in survival based on treatment modality. Results: Among 56,417 identified patients, the mean age at diagnosis was 70.1 years (SD = 10.7). Treatment modalities varied significantly over time (p
Source: Cancer Investigation - August 24, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Altered mRNA Expression of Genes Involved in Endocannabinoid Signalling in Squamous Cell Carcinoma of the Oral Tongue.
Authors: Alhouayek M, Boldrup L, Fowler CJ Abstract Little is known about the endocannabinoid (eCB) system in squamous cell carcinoma of the oral tongue (SCCOT). Here we have investigated, at the mRNA level, expression of genes coding for the components of the eCB system in tumour and non-malignant samples from SCCOT patients. Expression of NAPEPLD and PLA2G4E, coding for eCB anabolic enzymes, was higher in the tumour tissue than in non-malignant tissue. Among genes coding for eCB catabolic enzymes, expression of MGLL was lower in tumour tissue while PTGS2 was increased. It is concluded that the eCB system may be d...
Source: Cancer Investigation - August 21, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Synergistic Effects of PI3K and c-Myc Co-targeting in Acute Leukemia: Shedding New Light on Resistance to Selective PI3K- δ Inhibitor CAL-101.
Synergistic Effects of PI3K and c-Myc Co-targeting in Acute Leukemia: Shedding New Light on Resistance to Selective PI3K-δ Inhibitor CAL-101. Cancer Invest. 2019 Aug 14;:1-14 Authors: Riyahi N, Safaroghli-Azar A, Sheikh-Zeineddini N, Sayyadi M, Bashash D Abstract Enthusiasms into the application of PI3K-δ inhibitor CAL-101 has been muted due to the over-activation of compensatory molecules. Our results delineated that c-Myc suppression using 10058-F4 enhanced CAL-101 cytotoxicity in less sensitive cells through different mechanisms based on p53 status; while CAL-101-plus-10058-F4 induced G1...
Source: Cancer Investigation - August 17, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Effect of Doxorubicin on Squamous Cell Carcinoma of Skin: Assessment by MRI Relaxometry at 4.7T.
Authors: Sharma A, Sharma U, Jagannathan NR, Ray R, Raja Rajeswari M Abstract Squamous cell carcinoma (SCC) of skin has no standard treatment regimen, resulting in recurrences/metastasis. Although, doxorubicin (Dox), an anthracycline antibiotic has demonstrated some degree of efficacy. Molecular imaging can help in assessment of treatment response and prognosis of SCCs. MRI data showed that spin-spin relaxation (T2) time was longer (138 ± 2 msec) in Dox treated Test-II and there is no significant difference in spin-lattice relaxation (T1) time with respective controls. These findings fur...
Source: Cancer Investigation - August 17, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Change in Quality of Life after a Cancer Diagnosis among a Nationally Representative Cohort of Older Adults in the US.
This study aimed to examine QoL changes before and after a new cancer diagnosis using data from the National Health and Aging Trend Study (NHATS), linked to Medicare claims (N = 136). There was a significant increase in the relative odds of fair/poor self-reported health and needing help with Activities of Daily Living. There was also a marginal increase in depression, but no change in anxiety or pain scores. Results underscore importance of considering pre-cancer QoL when making treatment decisions for older adult cancer patients. PMID: 31379217 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - August 7, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Interleukin-6 Receptor (IL-6R) Expression in Human Gastric Carcinoma and its Clinical Significance.
Authors: Simondurairaj C, Krishnakumar R, Sundaram S, Venkatraman G Abstract The aim of the study is to analyse the expression of Interleukin-6 receptor in different human gastric tissue and to correlate with the clinicopathological features of the patients. Immunohistochemistry was done against the IL-6R antibody and the Q-score was calculated from the staining pattern. Higher Q-scores were observed in tumour cells than the adjacent normal cells which were statistically significant. We also observed a significant correlation between the expressions of IL-6R and the clinicopathological features These findings sugge...
Source: Cancer Investigation - July 23, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Elevation of Serum CEA in Patients with Squamous Cell Carcinoma of the Anus.
In this study, we used electronic health record data from a single urban cancer center to identify patients from 2004-2018 with anal cancer who have also had a pre-initial treatment CEA measurement. We identified 40 patients who met our eligibility criteria. Of those, 11 (27.5%) had an elevated pretreatment CEA. Elevated CEA was not associated with any of the clinical or demographic covariates; however, three out of five patients with a recurrence had an elevated CEA. PMID: 31319725 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - July 20, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Survival of Oral Cancer Patients in Different Ethnicities.
Authors: Ghani WMN, Ramanathan A, Prime SS, Yang YH, Razak IA, Abdul Rahman ZA, Abraham MT, Mustafa WMW, Tay KK, Kallarakkal TG, Doss JG, Cheong SC, Bustam AZ, Zain RB Abstract Previous studies found that ethnicity influences oral cancer patients' survival; however, most studies were limited to certain ethnic groups particularly from the West, thus of limited relevance to Asians where the disease is most prevalent. We investigated the relationship between ethnicity and patient survival in multi-racial Malaysia. 5-year survival rate was 40.9%. No statistically significant difference was observed in survival between ...
Source: Cancer Investigation - July 18, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Skin Toxicities with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Cancer Patients: A Meta-Analysis of Randomized Controlled Trials.
Authors: Sun W, Li J Abstract We fully investigate the skin toxicities of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in cancer patients. The studies about randomized controlled trials in cancer treatment with EGFR-TKIs were retrieved and the systematic evaluation was conducted. The results suggest that EGFR-TKIs significantly increase the risk of skin toxicities including all-grade rash, pruritus, dry skin, and high-grade rash, pruritus. However, the risk of high-grade dry skin did not increase. Rash was the most common toxicity. Physicians should be aware of skin toxicities and should ...
Source: Cancer Investigation - July 16, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Prognostic Value of Baseline Neutrophil-to-Lymphocyte Ratio in Outcome of Immune Checkpoint Inhibitors.
Authors: Xie X, Liu J, Yang H, Chen H, Zhou S, Lin H, Liao Z, Ding Y, Ling L, Wang X Abstract A meta-analysis of 14 studies (16 cohorts) incorporating 1751 participants was performed to evaluate the correlation between baseline neutrophil-to-lymphocyte ratio (NLR) and outcome of immune checkpoint inhibitors (ICI). The pooled hazard ratio (HR) suggested elevated pretreatment NLR was associated with poor OS (HR: 2.61, 95% confidence intervals (CI): 1.77-3.86, p 
Source: Cancer Investigation - July 16, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Quinacrine Depletes BCR-ABL and Suppresses Ph-Positive Leukemia Cells.
In conclusion, we demonstrate that QC depletes BCR-ABL protein and suppresses Ph-positive leukemia cells in vitro and in vivo. PMID: 31296070 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - July 13, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Factors Associated with Multidisciplinary Consultations in Patients with Early Stage Breast Cancer.
Conclusion: Early stage breast cancer patients were evaluated by a surgeon, radiation oncologist and medical oncologist less than 75% of the time. Enhanced coordination of care and navigation programs may improve the quality of care delivered. PMID: 31296072 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - July 13, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

A Pilot Study of Side Effects of Cancer Therapies and their Impact on Satisfaction with Life.
Authors: Kroker L, Dubois C, Münstedt K, Büntzel J, Keinki C, Hübner J Abstract This survey aimed at getting a first insight into diverse side effects and their association with satisfaction with life as well as the use of complementary and alternative medicine (CAM) in cancer patients. A total of 100 patients in a German University Hospital were included. General side effects like fatigue, fever, headache, limb pain and sleep disorders had a significant influence on the patients' satisfaction with life (p = .034 and p = .032, respectively). Concerning CAM, we could not detect any association between...
Source: Cancer Investigation - June 19, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Randomized Controlled Trial of a 4-Week Mindfulness Intervention among Cancer Survivors Compared to a Breathing Control.
Conclusions: An abbreviated mindfulness intervention in feasible in cancer survivors and signs of efficacy warrant further mindfulness studies among this population. PMID: 31198066 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - June 16, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

The Prognostic Significance of EIF3C Gene during the Tumorigenesis of Prostate Cancer.
Authors: Hu J, Luo H, Xu Y, Luo G, Xu S, Zhu J, Song D, Sun Z, Kuang Y Abstract Prostate cancer (PCa) is the most common malignant tumor for men. But the mechanism is unclear. EIF3C was shown to be overexpressed in PCa tissues and cell lines. EIF3C overexpression was correlated to age and tumor stage in PCa patients and indicated poor survival. The proliferation, migration, and invasiveness of PC3 cells were all inhibited after EIF3C knockdown. Additionally, the phosphorylation level of PI3K and Akt was downregulated while total NF-κB and Myc decreased after EIF3C knockdown. But the expression of IκB in...
Source: Cancer Investigation - June 13, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

The Investigation of Unplanned Hospital Visits and Admissions in the Children Receiving Chemotherapy.
This study aimed to determine incidence, risk factors of unplanned hospital visits children receiving chemotherapy. The study was conducted with 65 children. Data were collected using form consisting of questions regarding causes of their unplanned hospital visits. Chi-square test were used analysis of data. Three quarters of children receiving chemotherapy were determined to have unplanned hospital visits, majority of them were found to be admitted. Knowing high-risk factors for unplanned hospital visits and admissions of children receiving chemotherapy and applying appropriate interventions for discharge education and ho...
Source: Cancer Investigation - June 12, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Antitumor and Antiangiogenic Activities of Lenvatinib in Mouse Xenograft Models of Vascular Endothelial Growth Factor-Induced Hypervascular Human Hepatocellular Carcinoma.
Authors: Adachi Y, Matsuki M, Watanabe H, Takase K, Kodama K, Matsui J, Funahashi Y, Nomoto K Abstract High expression of vascular endothelial growth factor (VEGF) in patients with hepatocellular carcinoma (HCC) is associated with poor prognosis. Here, we investigated the antitumor activity of lenvatinib, a multiple receptor tyrosine kinase inhibitor, in VEGF-overexpressing HCC models. In human umbilical vein endothelial cells, lenvatinib showed potent inhibitory activities against VEGF-induced proliferation and VEGF/basic fibroblast growth factor-induced tube formation. In VEGF-overexpressing HCC xenograft models,...
Source: Cancer Investigation - April 23, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Expression of Interleukin-6 and Integrin ανβ6 in Colon Cancer: Association with Clinical Outcomes and Prognostic Implications.
Expression of Interleukin-6 and Integrin ανβ6 in Colon Cancer: Association with Clinical Outcomes and Prognostic Implications. Cancer Invest. 2019 Apr 14;:1-11 Authors: Liang B, Li L, Miao R, Wang J, Chen Y, Li Z, Zou X, Zhou M Abstract As important factors in the tumor microenvironment, interleukin-6 (IL-6) and integrin ανβ6 play significant roles in accumulating mutations that drive the progression and metastatic capacities of cancer. The aim of this study was to investigate the expression of IL-6 and integrin ανβ6, their clinical significance, as well as the...
Source: Cancer Investigation - April 17, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Cancer-Associated Fibroblasts Induce Epithelial-Mesenchymal Transition in Endometrial Cancer Cells by Regulating Pituitary Tumor Transforming Gene.
This study demonstrated that CAFs induced EMT in endometrial cancer cells by regulating PTTG. PMID: 30961403 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - April 10, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

CCR4 Expression in Tumor-Infiltrating Regulatory T Cells in Patients with Squamous Cell Carcinoma of the Lung: A Prognostic Factor for Relapse and Survival.
Authors: Asai N, Kubo A, Suzuki S, Murotani K, Numanami H, Yoshikawa K, Ueda R, Yamaguchi E Abstract To clarify the prognostic impact of tumor-infiltrating effector regulatory T cells (eTregs) in non-small cell lung cancer (NSCLC), eTregs were evaluated by immunohistochemical detection of CCR4 and Foxp3 in 108 consecutive surgical NSCLC tumors. Multivariate analysis showed that a high ratio of CCR4+ eTregs to total Tregs (≥40%) was the only independent risk factor for relapse-free survival (odds ratio [OR]: 6.54, 95% confidence interval: 1.67-25.7, p = .007) and overall survival (OR: 3.76, p&thinsp...
Source: Cancer Investigation - March 27, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2: A Novel Treatment Strategy for Glioblastoma.
Authors: Luwor R, Morokoff AP, Amiridis S, D'Abaco G, Paradiso L, Stylli SS, Nguyen HPT, Tarleton M, Young KA, O'Brien TJ, Robinson PJ, Chircop M, McCluskey A, Jones NC Abstract Glioma stem cells (GSCs) play major roles in drug resistance, tumour maintenance and recurrence of glioblastoma. We investigated inhibition of the GTPase dynamin 2 as a therapy for glioblastoma. Glioma cell lines and patient-derived GSCs were treated with dynamin inhibitors, Dynole 34-2 and CyDyn 4-36. We studied about cell viability, and GSC neurosphere formation in vitro and orthotopic tumour growth in vivo. Dynamin inhibition reduced gli...
Source: Cancer Investigation - March 27, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Mannose binding lectin and prediction of risk for chemotherapy induced febrile neutropenia in patients with a solid tumor.
In conclusion, serum MBL and MBL genotypes (-550H/L and -221X/Y) do not determine the risk for developing FN. PMID: 30907154 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - March 27, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Aquaporin-4 Expression Patterns in Glioblastoma Pre-Chemoradiation and at Time of Suspected Progression.
Authors: Levy M, Barletta S, Huang H, Grossman SA, Rodriguez FJ, Ellsworth SG, Dzaye O, Holdhoff M Abstract There has been controversy about the presence and potential role of aquaporin-4 (AQP4) in glioblastoma (GBM). We analyzed tissue from 22 patients with newly-diagnosed GBM as well as matching tissue from 17 of these cases who underwent repeat resection for suspected recurrence and performed immunohistochemical analysis for AQP-4 expression. While some degree of AQP4 expression was detected in all 22 cases (39 samples), there was no clear relationship between staining pattern and disease status (active versus i...
Source: Cancer Investigation - March 17, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Possible Role and Therapeutic Target of PDGF-D Signalling in Colorectal Cancer.
This study aimed to investigate the expression and putative involvement of PDGF-D signaling in colorectal carcinogenesis. PDGF-D was expressed in vascular endothelial cells in tumor and normal tissues. PDGF-D stimulation of cells altered genes of importance in carcinogenic processes. In addition, PDGF-D increased the proliferation rate while imatinib inhibited these effects. PDGF-D and its PDGF receptor beta (PDGFR-β) are expressed in colorectal cancer and blockage of PDGF-D/PDGFR-β signaling using tyrosine kinase inhibitors, such as imatinib, might be important in inhibiting tumor-promoting actions. PMID: 30...
Source: Cancer Investigation - March 8, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Serum Testosterone 60 Months after Passive-Scatter Proton Therapy for Localized Prostate Cancer.
Authors: Nichols RC, Morris CG, Bryant C, Hoppe BS, Henderson RH, Mendenhall WM, Li Z, Costa JA, Williams CR, Mendenhall NP Abstract Studies demonstrate a decline of ∼10% in serum testosterone (ST) level after X-ray radiotherapy for prostate cancer. We evaluated changes in ST for patients with low- and intermediate-risk prostate cancer receiving 70-82Gy(RBE) using passive-scatter proton therapy (PT). ST was checked at baseline (n = 358) and at 60+ months after PT (n = 166). The median baseline ST was 363.3 ng/dl (range, 82.0-974.0). The median ST 5 years after PT was 39...
Source: Cancer Investigation - March 8, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Oxidative DNA Damage-Mediated Genomic Heterogeneity Is Regulated by NKX3.1 in Prostate Cancer.
Authors: Debelec-Butuner B, Bostancı A, Ozcan F, Singin O, Karamil S, Aslan M, Roggenbuck D, Korkmaz KS Abstract The 8-hydroxy-2'-deoxyguanosine (8-OHdG) damages are base damages induced by reactive oxygen species. We aimed to investigate the role of Androgen Receptor and NKX3.1 in 8-OHdG formation and repair activation by quantitating the DNA damage using Aklides.NUK system. The data demonstrated that the loss of NKX3.1 resulted in increased oxidative DNA damage and its overexpression contributes to the removal of menadione-induced 8-OHdG damage even under oxidative stress conditions. Moreover, 8-oxoguanine DNA g...
Source: Cancer Investigation - March 8, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Digital Era of Mobile Communications and Smartphones: A Novel Analysis of Patient Comprehension of Cancer-Related Information Available Through Mobile Applications.
Authors: Kim C, Prabhu AV, Hansberry DR, Agarwal N, Heron DE, Beriwal S Abstract Many Americans use smartphone-based mobile applications to acquire health information. Our study evaluated the readability of mobile application-based patient educational materials (PEMs) about five prevalent cancers in the United States. The Apple and Google mobile application marketplaces were queried for breast, colon, lung, prostate, and stomach cancer-related applications, which were subsequently screened for PEMs and assessed with 10 validated readability assessments. Twenty-one pertinent applications yielded 249 articles that we...
Source: Cancer Investigation - March 4, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Outcome of Bevacizumab Therapy in Patients with Recurrent Glioblastoma Treated with Angiotensin System Inhibitors.
CONCLUSIONS: Overall the study supports a potential beneficial effect of antihypertensive treatment on prognosis of bevacizumab treated glioblastoma patients. PMID: 30727779 [PubMed - in process] (Source: Cancer Investigation)
Source: Cancer Investigation - February 10, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Expression of Circadian Clock Genes in Human Colorectal Cancer Tissues Using Droplet Digital PCR.
In conclusion, abnormal expression levels of the clock genes Per1 and Per3 in CRC tissue may be related to tumourigenesis and may provide future diagnostic and prognostic information. PMID: 30732490 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - February 10, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Mast Cells Are a Marked Source for Complement C3 Products That Associate with Increased CD11b-Positive Cells in Keratinocyte Skin Carcinomas.
Authors: Rahkola D, Laitala J, Siiskonen H, Pelkonen J, Harvima IT Abstract By using immunohistochemistry and antibodies that identify complement C3c (in C3 and C3b) or CD11b receptor, we report that the proportion C3c+ mast cells and the number of CD11b+ cells are increased in basal cell carcinoma (BCC). Instead, only CD11b+ cells are increased in squamous cell carcinoma/Bowen's disease, and only slightly so in actinic keratosis. Only C3c+ mast cells are increased in psoriasis. Furthermore, C3c+ mast cells correlated positively with CD11b+ cells, and iC3b immunoreactivity was detected around tryptase+ mast cells. ...
Source: Cancer Investigation - January 29, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Practice Implications of Expanded Genetic Testing in Oncology.
Authors: Korngiebel DM, Zech JM, Chappelle A, Burke W, Carline JD, Gallagher TH, Fullerton SM Abstract Genetic test use in oncology is growing, yet providers' experiences with evolving testing norms and their implications for patient care remain under-explored. In interviews with oncologists and cancer genetics professionals, 22 key informants described the increasing importance of germline results for therapeutic decision-making, preference for ordering tests directly rather than referring, and rapid adoption of cancer gene panels for testing. Implications for informed consent, result interpretation, and pa...
Source: Cancer Investigation - January 26, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research