Purportedly high cancer risk among US sailors on nuclear-powered ships.
Authors: Wakeford R PMID: 32530325 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - June 14, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Response to Richard Wakeford's letter to the Editor "Purportedly high cancer risk among US sailors on nuclear powered ships."
Response to Richard Wakeford's letter to the Editor "Purportedly high cancer risk among US sailors on nuclear powered ships." Cancer Invest. 2020 Jun 12;:1-3 Authors: Busby C PMID: 32530715 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - June 14, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Adenosine deaminase in pleural effusion and its relationship with clinical parameters in patients with malignant pleural mesothelioma.
We examined 329 patients from February 2002 to July 2013. There were 131 MPM cases with ADA levels of 32.29 IU/L; 117 LC cases with ADA levels of 21.12 IU/L; 54 benign disease cases with ADA levels of 20.98 IU/L. A significant difference existed in pleural effusion ADA levels between MPM and benign disease patients. Pleural effusion ADA levels were significantly higher in MPM patients. PMID: 32468861 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - May 31, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

In vitro effect of Dovitinib (TKI258), a multi-target angiokinase inhibitor on aggressive meningioma cells.
CONCLUSIONS: This study establishes the groundwork for development of Dovitinib as a therapeutic agent for high-grade AM with either frequent codeletion or mutated CHEK2 and NF2, an avenue with high translational potential. PMID: 32441531 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - May 23, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Computed Tomography Colonography versus Standard Optical Colonoscopy for the Detection of Colorectal Polyp in Patients who faced Curative Surgery for Colorectal Cancer: A Diagnostic Performance Study.
Authors: He L, Guo L, Hu C Abstract Data regarding Computed Tomography colonography, standard optical colonoscopy, and enhanced colonoscopy/histopathology at 1-year after surgery and at 6-month intervals for the next 2 years of 345 patients who faced curative surgery for colorectal cancer were included in the analysis. Computed Tomography colonography and standard optical colonoscopy both detected 298 polyps as suspicious. With reference to enhanced colonoscopy/histopathology, sensitivities for the detection of any polyps for Computed Tomography colonography and standard optical colonoscopy were 0.952 and 0.906. Wh...
Source: Cancer Investigation - May 21, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

BST2 promotes tumor growth via multiple pathways in hepatocellular carcinoma.
In conclusion, HCC patients with higher BST2 expression were more predisposed to poorer clinical symptoms and unfavorable prognosis. PMID: 32427495 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - May 21, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Lung cancer mortality and the availability of chest computerized tomography: a longitudinal nationwide study.
Authors: Ponte EV, Fanelli MF, Ferreira RTR, Pereira JF, Arcadipani MSES, Lima VB, Marchi E, Santos RSD Abstract Lung-cancer screening with chest computerized tomography (CT) is not easy to introduce in low-medium resource countries due to cost issues. We investigated whether the increasing availability of chest CT exams in Brazil, in spite of no lung-cancer screening protocol, was associated with lung-cancer death rate along 10-year follow-up. We performed regressions to estimate the rate ratio between chest CT exams and lung-cancer deaths per 105 inhabitants. We stratified data per municipality. Regressions were ...
Source: Cancer Investigation - May 16, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Epidemiology and risk factors of osteosarcoma.
Authors: Sadykova LR, Ntekim AI, Muyangwa-Semenova M, Rutland CS, Jeyapalan JN, Blatt N, Rizvanov AA Abstract Osteosarcoma is a rare tumor diagnosed at any age; however younger age is a common risk factor. In addition, multiple factors are believed to contribute to higher rates of osteosarcoma, particularly race and gender. Although diagnosed worldwide, osteosarcoma is found to be more prevalent in Africa with high numbers of cases reported in Nigeria, Uganda, and Sudan. Additionally, higher rates are detected in African Americans, suggesting a genetic predisposition linked to race. This review focuses on identifyi...
Source: Cancer Investigation - May 15, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Centrosome abnormalities and polyploidy in murine mammary carcinomas with different degrees of hormone responsiveness.
Authors: Bilinski M, Lanari C, Fabris VT Abstract Centrosome amplification leads to aberrant mitosis, giving rise to aneuploidy and it has been associated with poor prognosis in human cancers. The aim of this study was to evaluate the relationship between polyploidy, centrosome abnormalities and response to endocrine treatment in progestin-induced mouse mammary carcinomas. We found cells with three or more centrosomes in the polyploid tumors. The endocrine unresponsive tumors showed a higher average number of centrosomes per cell than the responsive tumors. The results suggest an association between polyploidy and ...
Source: Cancer Investigation - May 9, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

The prognostic significance of IGF-1R and the predictive risk value of circulating IGF-1 in Tunisian patients with laryngeal carcinoma.
Authors: Ben Elhadj M, Goucha A, Fourati A, Adouni O, Dhambri S, Hsairi M, El May MV, Mokni Baizig N Abstract The aim was to evaluate the clinical impact of IGF-1/IGF-1R in Tunisian laryngeal carcinoma. A high IGF-1R immunohistochemical expression was found in our series (81.43%). A tendency toward an association between IGF-1R expression and lymph node metastasis was found (p = 0.068). Patients with positive IGF-1R expression showed a short disease free survival (p = 0.053) and a high recurrence rate. Furthermore, circulating IGF-1 levels sera, detected by ELISA, were higher among patie...
Source: Cancer Investigation - April 22, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Correction.
Authors: PMID: 32292076 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - April 16, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

HSP90 and Co-chaperones: Impact on Tumor Progression and Prospects for Molecular Targeted Cancer Therapy.
Authors: Jafari A, Rezaei-Tavirani M, Farhadihosseinabadi B, Taranejoo S, Zali H Abstract Heat shock protein 90 (HSP90), a highly and unique chaperone, presents as a double-edged sword. It plays an essential role in many physiological and pathological processes, including tumor development. The current review highlights a recent understanding of the roles of HSP90 in molecular mechanisms underlying cancer survival and progression. HSP90 and its client proteins through the regulation of oncoproteins including signaling proteins, receptors and transcriptional factors involved in tumorigenesis. It also has potential c...
Source: Cancer Investigation - April 12, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Construction of a nomogram after using propensity score matching to reveal the prognostic benefit of tumor resection of stage IV M1a non-small-cell lung cancer patients.
Authors: Yin G, Hua X, Liao Y, Huang C, Fan X Abstract The aim of this work was to determine whether tumor resection could improve the prognosis of M1a non-small-cell lung cancer (NSCLC) patients. We obtained patient data from the Surveillance, Epidemiology, and End Results (SEER) database and used propensity score matching (PSM) to reduce the influence of confounding variables. Univariate and multivariate Cox regression analyses were used to identify independent prognostic factors, and the prediction results were visualized using the nomogram. A total of 772 patients with and without tumor resection were enrolled ...
Source: Cancer Investigation - April 9, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

UHRF1, a regulator of methylation, as a diagnostic and prognostic marker for lung cancer.
Authors: Goto D, Komeda K, Uwatoko N, Nakashima M, Koike M, Kawai K, Kodama Y, Miyazawa A, Tanaka I, Hase T, Morise M, Hasegawa Y, Kawabe T, Sato M Abstract We evaluated the value of UHRF1, a regulator of methylation, as a biomarker for lung cancer. UHRF1 is expressed at higher levels in both lung adenocarcinoma (AD) and squamous cell carcinoma (SQ); however, a meta-analysis showed that UHRF1 expression is correlated with worse survival in patients with AD but not in those with SQ. UHRF1 knockdown suppressed the growth of lung cancer cell lines through G1 cell cycle arrest in some cell lines. These results suggest ...
Source: Cancer Investigation - March 29, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Flow cytometry characterization of pluripotent transmembrane glycoproteins on resident cervix uteri cells in patients screened for cervical cancer.
Authors: Colacurci N, Schettino MT, Grimaldi V, De Luca FP, Mansueto G, Costa D, Cacciatore F, De Franciscis P, Napoli C Abstract The aim of this study was to characterize both by flow cytometry analysis and immunohistochemistry cervix uteri cells of nulliparous women screened for cervical intraepithelial neoplasia (CIN) in comparison to a group without CIN by using mesenchymal stem cell-like and hematopoietic lineage markers. A significant expression for CD29, CD38, HLA-I and HLA-II was correlated positively to the CIN degree and it was more relevant in patients positive for human papilloma virus (HPV). Thus, iden...
Source: Cancer Investigation - March 27, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

The function and prognostic significance of Cripto-1 in colorectal cancer.
Authors: Sato J, Karasawa H, Suzuki T, Nakayama S, Katagiri M, Maeda S, Ohnuma S, Motoi F, Naitoh T, Unno M Abstract Cripto-1 is a plasma membrane protein which is not expressed in adult tissue, but some tumors are accompanied by re-activation. We studied the clinical and biological significance of Cripto-1 in colorectal cancer. Cripto-1 was positive in 68 out of 192 cases (35%) by immunohistochemistry. Cripto-1 expression was correlated with worse prognosis and was an independent prognostic factor. Cripto-1-silenced colorectal cancer cell lines had reduced cell proliferation, migration, and activation of Akt and M...
Source: Cancer Investigation - March 13, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Distribution of femoral metastases; potential role for extended FDG PET/CT scanning.
This study investigates the distribution of femoral metastases in cancer patients, specifically addressing the incidence of distal femoral metastases. PET/CT examinations routinely extend only to mid-thigh level, precluding detection of distal metastases. We found a total of 208 femoral metastases in 112 patients. 30% had distal femoral metastases in addition to other areas of involvement. 7% of patients with femoral metastases had only distal femur disease. 6 patients had distal pathologic fractures. Exclusion of the distal femur during PET/CT may result in a missed or delayed diagnosis that could contribute to the develo...
Source: Cancer Investigation - February 28, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Financial toxicity, financial abuse, or financial torture: let's call it what it is!
Authors: Lyman GH, Kuderer N PMID: 32093505 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - February 26, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

The Composition Alteration of Respiratory Microbiota in Lung Cancer.
CONCLUSIONS: The respiratory microbiota composition of respiratory microbiota significantly differs between lung cancer patients and healthy individuals, and may be used as potential biomarker of lung cancer. In addition, larger sample size, standardized procedures, dynamic monitoring, metabolomics and culturomics are needed to confirm these results. PMID: 32073913 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - February 21, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

High cancer risk in US naval personnel serving in nuclear powered ships.
Authors: Busby C Abstract The USA Defence Threat Reduction Agency provided data in 2014 on the health status, including cancer, of the 4,843 sailors on the nuclear-powered United States Ship (USS) Ronald Reagan over the 2.55-year period from May 12th 2011 to Dec 31st 2013. Also provided were data on a matched control group of 65,269 US Navy personnel. Examination of the control population relative to the US national data gives a Relative Risk for all malignancies of RR =9.2 (95% CI 8.48 
Source: Cancer Investigation - February 19, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

An Unusual Presentation of HTLV associated Adult T Cell Lymphoma/ Leukemia- an Eye that said it 'A (T) LL'.
Conclusion: ATLL can have rare clinical presentations, a diagnosis of which requires an eye for suspicion and a comprehensive work up. To the best of our knowledge, ATLL presenting with two subsets of CD4+/CD4- populations has not been reported. PMID: 32037902 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - February 12, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Fatal adverse events associated with Pembrolizumab in cancer patients: A Meta-analysis.
Authors: Sher AF, Golshani GM, Wu S Abstract Background: Pembrolizumab as an immune checkpoint inhibitor (ICI) has emerged as an effective treatment for many cancers. It has unique immune related adverse events and little is known about its risk of fatal adverse events (FAE). We conducted a meta-analysis of clinical trials to determine the incidence and risk of fatal adverse events with pembrolizumab.Methods: A systematic search for phase I-III clinical trials of pembrolizumab was conducted using databases including PUBMED, and abstracts presented at the American Society of Clinical Oncology (ASCO) conferences unti...
Source: Cancer Investigation - January 29, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Serum C-reactive protein level predicts clinical outcomes in patients with non-small cell lung cancer harboring EGFR mutations.
Authors: Koyama N, Aoshiba K, Nakamura H Abstract The aim of this study was to assess the association of serum C-reactive protein (CRP) levels with outcomes in 81 patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). Patients with high serum CRP levels had lower therapeutic responses to EGFR-tyrosine kinase inhibitors (43.8%), and shorter time to treatment failure (TTF; 5.8 months) and overall survival (OS; 14.2 months) than those with low CRP levels. In multivariate analysis, serum CRP level was associated with TTF (hazard ratio [HR] 4.86) and OS (HR 49.42). High serum C...
Source: Cancer Investigation - January 29, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Safety of combination immune checkpoint inhibitors compared to monotherapy; a systematic review and meta-analysis.
Authors: A M Abdelhafeez A, Shohdy KS, Ibrahim W Abstract Combination immune checkpoint inhibitors (ICIs) achieved higher efficacy than monotherapy in many types of cancers. We searched PubMed, Scopus, and Cochrane databases for randomized phase II/III trials in cancer patients receiving combination ICIs vs. Monotherapy. Our search retrieved 934 records. Eight studies were found to be eligible for meta-analysis recruiting 2544 patients. Combined immunotherapy nivolumab plus ipilimumab was associated with statistically significant higher risk of all grade adverse events (AE), and discontinuation due to all grade AEs...
Source: Cancer Investigation - January 26, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Amplification of chromosome 17 centromere (CEP17) in breast cancer patients with a result of HER2 2+ by immunohistochemistry.
CONCLUSION: Patients with amplification of CEP17 had a co-amplified HER2 and were more commonly HER2+, LN positive and grade 3 in the nuclear component of grade. PMID: 31977265 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - January 26, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Discriminant Analysis of Lung Cancer using Nonlinear Clustering of Copy Numbers.
Conclusions: The results reveal high discriminant power of chromosomes 8, 5, 1, 3, and 19 for identifying cancer with the highest sensitivity of 75% yielded by chromosome 5. Bottom 5 chromosomes 9, 6, 4, 13, and 21 show low discriminant power with accuracy of below 54% where true cancer and normal samples are grouped into substantially overlapping groups using copy numbers. This indicates the similarities of copy numbers obtained for cancer and normal samples on these chromosomes. PMID: 31977287 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - January 26, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Ras mediated activation of NF- κB and DNA damage response in carcinogenesis.
Ras mediated activation of NF-κB and DNA damage response in carcinogenesis. Cancer Invest. 2020 Jan 23;:1-58 Authors: Ahmad A, Ahsan H Abstract Cancer is a multi-step process during which cells acquire mutations that eventually lead to uncontrolled cell growth and division and evasion of programmed cell death. The oncogenes such as Ras and c-Myc may be responsible in all three major stages of cancer i.e. early, intermediate and late. The NF-κB has been shown to control the expression of genes linked with tumor pathways such as chronic inflammation, tumor cell survival, anti-apoptosis, proli...
Source: Cancer Investigation - January 25, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Association between single nucleotide polymorphisms and glioma risk: a systematic literature review.
This study aimed to determine the main single nucleotide polymorphisms that are associated with an increased or decreased risk of glioma development in healthy individuals. We conducted a systematic review of the articles published in English on the PUBMED database between January 2008 and December 2017. Our search resulted in a total of 743 articles; however, only 56 were included in this review. A total of 148 polymorphisms were found, which involved 64 different genes. The polymorphisms that were most associated with an increased risk of glioma development were polymorphic variants rs179782, rs13181, and rs3791679 of th...
Source: Cancer Investigation - January 22, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Clinic-pathological features of breast ductal carcinoma in situ with micro-invasion.
Authors: Zheng J, Zhou T, Li F, Shi J, Zhang L Abstract Background: To investigate the differences of clinic-pathological features among ductal carcinoma in situ (DCIS), ductal carcinoma in situ with micro-invasion (DCIS-MI) and early invasive carcinoma (IDC) in stage T1.Methods: From January 2014 to December 2018, 308 cases DCIS, DCIS-MI 92 cases and 111 cases of T1a, 343 cases of T1b, and 1032 cases of T1c were investigated in a retrospective analysis. The population and clinic-pathological characteristics including age, menstrual status, surgical mode, lymph node status and molecular markers were compared in eac...
Source: Cancer Investigation - January 16, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Evaluation of a liquid biopsy protocol using ultra-deep massive parallel sequencing for detecting and quantifying circulation tumor DNA in colorectal cancer patients.
Authors: Nguyen HT, Tran DH, Ngo QD, Pham HT, Tran TT, Tran VU, Pham TN, Le TK, Le NT, Nguyen NM, Vo BT, Nguyen LT, Nguyen TV, Bui QTN, Nguyen HN, Le LGH, Do DM, Do TT, Truong Dinh K, Phan MD, Tran LS, Giang H, Nguyen HN Abstract The identification and quantification of actionable mutations are critical for guiding targeted therapy and monitoring drug response in colorectal cancer. Liquid biopsy (LB) based on plasma cell-free DNA analysis has emerged as a non-invasive approach with many clinical advantages over conventional tissue sampling. Here, we developed a LB protocol using ultra-deep massive parallel sequenci...
Source: Cancer Investigation - January 16, 2020 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Hsa-let-7b suppresses cell proliferation by targeting UHRF1 in melanoma.
In conclusion, hsa-let-7b regulates melanoma cells proliferation in vitro by targeting UHRF1. PMID: 31873045 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - December 26, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Overexpression of regucalcin supresses the growth of human osteosarcoma cells in vitro: Repressive effect of extracellular regucalcin.
Authors: Yamaguchi M, Murata T Abstract Regucalcin plays a pivotal role as a suppressor of human carcinogenesis, and downregulation of regucalcin expression may contribute to the promotion of human osteosarcoma. Overexpression of regucalcin suppressed the proliferation of Saos-2 human osteosarcoma cells in vitro and decreased the protein levels of multiple signaling components, transcription factors, and tumor suppressors. Interestingly, extracellular regucalcin repressed colony formation and proliferation of Saos-2 cells, and reduced the protein levels of multiple signaling components, cell cycle inhibitor, and va...
Source: Cancer Investigation - December 24, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

A Novel lncRNA HOXC-AS3 Acts as a miR-3922-5p Sponge to Promote Breast Cancer Metastasis.
Conclusions: The novel lncRNA HOXC-AS3 acts as a miR-3922-5p sponge to upregulate PPP1R1A protein expression, and thus results in promoting breast cancer metastasis. HOXC-AS3 could be a novel therapeutic target for breast cancer therapeutics. PMID: 31797701 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - December 6, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Development and assesment of nano-technologies for cancer treatment: cytotoxicity and hyperthermia laboratory studies.
Authors: Medina-Ramírez IE, Díaz de León Olmos MA, Muñoz Ortega MH, Zapien JA, Betancourt I, Santoyo-Elvira N Abstract Cancer treatment by magnetic hyperthermia offers numerous advantages, but for practical applications many variables still need to be adjusted before developing a controlled and reproducible cancer treatment that is bio-compatible (non-damaging) to healthy cells. In this work, Fe3O4 and CoFe2O4 were synthesized and systematically studied for the development of efficient therapeutic agents for applications in hyperthermia. The biocompatibility of the materials was further ...
Source: Cancer Investigation - December 4, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Inhibitory Effects of Indomethacin in Human MNNG/HOS Osteosarcoma Cell Line In Vitro.
Authors: Mirshahidi S, de Necochea-Campion R, Moretta A, Williams NL, Reeves ME, Otoukesh S, Mirshahidi HR, Khosrowpour S, Duerksen-Hughes P, Zuckerman LM Abstract Recurrence or metastasis remains the major cause of poor prognosis and mortality in Osteosarcoma patients. Therefore, development of more effective therapeutic approaches is required. We showed that indomethacin, significantly induces apoptosis in MNNG/HOS cell line, which was confirmed by morphological changes, increased Annexin-V + cells and nuclear fragmentation. Apoptosis was accompanied by increased cleavage of caspase-3 and PARP, sugg...
Source: Cancer Investigation - November 27, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Co-expression network analysis identified genes associated with Cancer Stem Cell Characteristics in Lung squamous cell carcinoma.
Conclusions: To conclude, mRNAsi play an important role in LSCC. Five key genes (BUB1, BIRC5, CCNB2, KIF15 and SPAG5) related to mRNAsi were screened, which may act as therapeutic targets for inhibiting the stem cell characteristics of LSCC. PMID: 31770041 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - November 27, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

New Insights into the Epidemiology of Prostate Cancer in Ontario.
Authors: Abrahamyan L, Huszti E, Bremner KE, Pechlivanoglou P, Mitsakakis N, Krahn M Abstract The epidemiology of prostate cancer (PC) continues to change. We evaluated the changes in incidence, in average age at diagnosis, and in survival from 1992 to 2015 in Ontario. We compared the cumulative incidence of PC-specific and non PC-specific mortality using two algorithms for cause of death: Method 1 assigned deaths from 'other cancers' to non PC-specific causes, and Method 2 assigned these cases to PC-specific mortality. There were 188,714 cases diagnosed with PC between 1992-2015 in Ontario. The average age at diag...
Source: Cancer Investigation - October 18, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Astonishing Evolution in Oropharyngeal Cancer with Immunotherapy: A Case Report.
Conclusion: Further studies are needed in order to obtained predictive index of immunotherapy responding, aiming to select appropriately patients for this treatment. PMID: 31619066 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - October 18, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Preparation of Diphtheria and Pseudomonas Exotoxin A Immunotoxins and Evaluation of Their Cytotoxicity Effect on SK-BR-3, BT-474, and MDA-MB-231 Breast Cancer Cell Lines.
In this study, we introduce immunotoxins comprising of truncated pseudomonas exotoxin A (PEA) and diphtheria toxin (DT) conjugated to trastuzumab. The effectiveness of 20 and 30 μg/ml immunotoxins and trastuzumab were studied on SK-BR-3 and BT-474 HER2/neu positive breast cancer cell lines by a cell death assay test. The produced immunotoxins have the potential to reduce the therapeutic dose of the trastuzumab and in the same time achieve higher efficiency. PMID: 31597492 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - October 11, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Oncological Outcome After Radical Prostatectomy without Pelvic Lymph Node Dissection for Localized Prostate Cancer: Follow-up Results in a Single Institution.
In this study, we reported oncological outcome in consecutive 146 patients who underwent RP without PLND. Although 27% of our patients developed biochemical recurrence, the estimated 5-year overall survival rates were 100%, 96.3%, and 95.7% in the low-, intermediate-, and high-risk groups, respectively. These data in our patients were not inferior to those in previous reports that investigated the survivals in patients who received PLND during RP. The therapeutic significance of PLND should be re-evaluated. PMID: 31597501 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - October 11, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Leptomeningeal Metastases in Renal Cell Carcinoma at Initial Diagnosis: 2 Case Reports and Literature Review.
Authors: Dridi M, Bouleftour W, Rivoirard R, Dal Col P, Langrand-Escure J, Vassal C, Guillot A Abstract Leptomeningeal metastasis (LM) in solid tumors are rare, even more in renal cell carcinoma (RCC). To date there is a lack of consensual treatment modalities of leptomeningeal metastasis. Furthermore, with the improvement of outcomes and more effective systemic targeted therapies, the management of leptomeningeal metastasis becomes a real challenge. We here report two cases of RCC with leptomeningeal metastasis at initial diagnosis. Both patients had concurrent adjacent skull bone metastasis. Therapeutic managemen...
Source: Cancer Investigation - October 5, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Identifying Similarities and Disparities between DNA Copy Number Changes in Cancer and Matched Blood Samples.
Conclusions: The results showed that a few chromosomes have a large number of MICs exceeding a high threshold. These locations can potentially be used to identify early indicators of NSCLC. In contrast, second group of chromosomes have several locations with small MICs which are potential candidates to develop biomarkers for discriminating cancer from the matched blood sample. Moreover, there is a third group of chromosomes with a large number of MICs exceeding a high threshold and a large set of MICs below a low threshold. These locations can help with both finding early indicators of cancer and developing biomarkers for ...
Source: Cancer Investigation - October 5, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Increased Risk of Hypertension with Enzalutamide in Prostate Cancer: a Meta-Analysis.
Authors: Zhu X, Wu S Abstract Hypertension is associated with enzalutamide in the treatment of prostate cancer. We performed a meta-analysis of randomized clinical trials to determine the risk of hypertension. Databases including Pubmed and Google scholar were searched to identify randomized clinical trials with enzalutamide. A total of seven studies including 7,347 patients were selected. The overall incidences of all-grade and high-grade hypertension were 11.9% (95%% CI: 8.8-16.0%) and 4.9% (95%% CI: 3.5-6.8%) respectively, with a relative risk of 2.82 (95%% CI: 2.34-3.38, P 
Source: Cancer Investigation - September 28, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers.
Authors: Záveský L, Jandáková E, Weinberger V, Minář L, Hanzíková V, Dušková D, Drábková LZ, Hořínek A Abstract Ovarian cancer is the deadliest gynecologic cancer. The large-scale microRNA (miRNA) expression profiling and individual miRNA validation was performed to find potential novel biomarkers for ovarian cancer. The most consistent overexpression of miRs-200b-3p, 135 b-5p and 182-5p was found in both ascitic fluid and tumors and suggests their potential as oncogenes. miR-451a was consistently underexpressed so may be a...
Source: Cancer Investigation - September 20, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Socioeconomic Factors Associated with Lack of Treatment in Early Stage Non-Small Cell Lung Cancer.
Authors: Dalwadi SM, Zhang J, Bernicker EH, Butler EB, Teh BS, Farach AM Abstract With modern radiotherapy, stage I non-small cell lung cancer (S1NSCLC) cure is extended to nonsurgical candidates. Despite this, some S1NSCLC remains untreated. We aim to identify factors associated with no treatment. 62,213 S1NSCLC cases were identified (SEER: 2004-2012). Demographics were compared using Chi-squared. Multivariate analysis was performed using COX proportional HR. 11.9% of the 7373 patients lacked treatment. No insurance, Medicaid-dependence, unmarried status, advancing age, lower income, African American and Asian/Pac...
Source: Cancer Investigation - September 20, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Circulating Cell Free Nuclear DNA, Mitochondrial DNA and Global DNA Methylation: Potential Noninvasive Biomarkers for Breast Cancer Diagnosis.
Authors: Pasha HA, Rezk NA, Riad MA Abstract Eighty seven women with benign breast lesion, 120 patients with breast cancer (BC) and one hundred controls were included in the study. Quantification of mtDNA and nDNA was done by qPCR. Global DNA methylation was measured using ELISA. Circulating cell-free nDNA and mtDNA were significantly elevated in BC and benign breast lesions patients. Global methylation was significantly low in BC patients. Combining the studied parameters in one panel, nDNA/mtDNA/hypomethylation, improved their sensitivity in detecting BC to reach 92.5%. Circulating cell-free nDNA, mtDNA and globa...
Source: Cancer Investigation - September 14, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Effect of Imipramine on radiosensitivity of Prostate Cancer: An In Vitro Study.
This study was performed to investigate the radiosensitizing effect of IMI on DU145 prostate cancer cell. Cells were divided into 4 groups. Cell index, apoptotic activity, cell cycle arrest, oxidative stress and EAG1 channel currents were determined in all groups. Our findings showed that combined treatment with IMI and radiotherapy (RAD) did not enhance radiosensitivity of DU145 cells but as unexpected finding, treatment of IMI alone was more effective in DU145 cells. PMID: 31496302 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - September 11, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Rumors of the Death of Biosimilars Have Been Greatly Exaggerated.
Authors: Lyman GH, Kuderer NM PMID: 31500458 [PubMed - as supplied by publisher] (Source: Cancer Investigation)
Source: Cancer Investigation - September 11, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Virotherapy: Current Trends and Future Prospects for Treatment of Colon and Rectal Malignancies.
Authors: Lee CL, Veeramani S, Molouki A, Lim SHE, Thomas W, Chia SL, Yusoff K Abstract Colorectal cancer (CRC) is one of the most common malignancies. In recent decades, early diagnosis and conventional therapies have resulted in a significant reduction in mortality. However, late stage metastatic disease still has very limited effective treatment options. There is a growing interest in using viruses to help target therapies to tumour sites. In recent years the evolution of immunotherapy has emphasised the importance of directing the immune system to eliminate tumour cells; we aim to give a state-of-the-art over-vi...
Source: Cancer Investigation - September 11, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research

Clinical significance of tumor-infiltrating T cells and programmed death ligand-1 in patients with pancreatic cancer.
Authors: Yoshida S, Ito Z, Suka M, Bito T, Kan S, Akasu T, Saruta M, Okamoto M, Kitamura H, Fujioka S, Misawa T, Akiba T, Yanagisawa H, Sugiyama H, Koido S Abstract The associations of the immunological status of the pancreatic ductal adenocarcinoma (PDA) microenvironment with prognosis were assessed. A high tumor-infiltrating lymphocyte (TIL) density was associated with a better prognosis. Importantly, even with a high density of TILs, the PDA cells with programmed cell death-ligand 1 (PD-L1) expression showed a worse prognosis than the patients with negative PD-L1 expression. A significant association between a b...
Source: Cancer Investigation - September 8, 2019 Category: Cancer & Oncology Tags: Cancer Invest Source Type: research