Applications of Inorganic Nanomaterials against Tuberculosis: A Comprehensive Review
Curr Drug Deliv. 2024 Apr 30. doi: 10.2174/0115672018295247240426055330. Online ahead of print.ABSTRACTTuberculosis (TB) continues to pose a significant global health threat, with millions of new infections recorded annually. Current treatment strategies, such as Directly Observed Treatment (DOT), face challenges, including patient non-compliance and the emergence of drug-resistant TB strains. In response to these obstacles, innovative approaches utilizing inorganic/metallic nanomaterials have been developed to enhance drug delivery to target alveolar macrophages, where Mycobacterium tuberculosis resides. These nanomateria...
Source: Current Drug Delivery - May 2, 2024 Category: Drugs & Pharmacology Authors: Debabrata Ghosh Dastidar Arnab Roy Gourav Ghosh Supratim Mandal Source Type: research
Multidrug-Resistant tuberculosis
The objective of this review is to increase awareness of the need for rapid and precise detection of MDR-TB cases to decrease morbidity and mortality of this infectious disease worldwide.PMID:38697459 | DOI:10.1016/j.cca.2024.119701 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - May 2, 2024 Category: Chemistry Authors: Dika Apriliana Wulandari Yeni Wahyuni Hartati Abdullahi Umar Ibrahim Dian Ayu Eka Pitaloka None Irkham Source Type: research
Pyridinium-Yne Click Polymerization: A Facile Strategy toward Functional Poly(Vinylpyridinium Salt)s with Multidrug-Resistant Bacteria Killing Ability
In this study, we demonstrate a simple and efficient strategy for synthesizing functional poly(vinylpyridinium salt)s via pyridinium-yne click polymerization. This click polymerization could proceed with high atom economy under mild conditions without any external catalyst, yielding soluble and thermally stable poly(vinylpyridinium salt)s with satisfactory molecular weights and well-defined structures in excellent yields. Additionally, the incorporation of luminescent units such as fluorene, tetraphenylethylene, and triphenylamine into the polymer backbone confers excellent aggregation-enhanced emission properties upon the...
Source: Angewandte Chemie - May 2, 2024 Category: Chemistry Authors: Benzhao He Ying Li Meng Li Miaomiao Kang Xinyue Liu Jiachang Huang Dong Wang Jacky W Y Lam Ben Zhong Tang Source Type: research
Multidrug resistance in < em > Salmonella < /em > isolates of swine origin: mobile genetic elements and plasmids associated with cephalosporin resistance with potential transmission to humans
Appl Environ Microbiol. 2024 May 2:e0026424. doi: 10.1128/aem.00264-24. Online ahead of print.ABSTRACTThe emergence of foodborne Salmonella strains carrying antimicrobial resistance (AMR) in mobile genetic elements (MGE) is a significant public health threat in a One Health context requiring continuous surveillance. Resistance to ciprofloxacin and cephalosporins is of particular concern. Since pigs are a relevant source of foodborne Salmonella for human beings, we studied transmissible AMR genes and MGE in a collection of 83 strains showing 9 different serovars and 15 patterns of multidrug resistant (MDR) previously isolat...
Source: Applied and Environmental Microbiology - May 2, 2024 Category: Microbiology Authors: V Garrido A Arrieta-Gisasola L Migura-Garc ía L Laorden M J Grill ó Source Type: research
Combating multidrug-resistance in < em > S. pneumoniae < /em > : a G-quadruplex binding inhibitor of efflux pump and its bio-orthogonal assembly
This study presents a pioneering strategy to combat antibiotic resistance by genetically reducing drug efflux pump expression through G-quadruplex stabilization, offering promising avenues for addressing antibiotic resistance.PMID:38694210 | PMC:PMC11059089 | DOI:10.1093/narmme/ugae005 (Source: Molecular Medicine)
Source: Molecular Medicine - May 2, 2024 Category: Molecular Biology Authors: Ritapa Chaudhuri Thumpati Prasanth Debasmita Biswas Subhranshu Mandal Jyotirmayee Dash Source Type: research
Development of a prototypic, field-usable diagnostic tool for the detection of gram-positive cocci-induced mastitis in cattle
CONCLUSIONS: Our study shows that EF-Tu is a promising target for LFIA and we have delivered evidence that further evaluation could improve test parameters and fill the gap in the mastitis diagnostics market.PMID:38698383 | DOI:10.1186/s12917-024-04028-5 (Source: Cell Research)
Source: Cell Research - May 2, 2024 Category: Cytology Authors: Anna Dobrut Jakub Skibi ński Adrian Bekier Kamil Dro żdż Karolina Rudnicka Przemys ław Płociński Izabela Siemi ńska Monika Brzychczy-W łoch Source Type: research
Effectiveness, cost, and safety of four regimens recommended by WHO for RR/MDR-TB treatment: a cohort study in Eastern China
CONCLUSIONS: For RR/MDR-TB patients in China who meet the criteria for short-term regimens, the short-term regimens were proven to be the most cost-effective of the four regimens recommended by WHO. For RR/MDR-TB patients in China who don't meet the criteria for short-term regimens, the new long-term injectable regimens are more cost-effective than the remaining two regimens.PMID:38697138 | DOI:10.1080/07853890.2024.2344821 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Pengcheng Gu Peng Lu Hui Ding Qiao Liu Xiaoyan Ding Yongfa Chen Limei Zhu Source Type: research
Applications of Inorganic Nanomaterials against Tuberculosis: A Comprehensive Review
Curr Drug Deliv. 2024 Apr 30. doi: 10.2174/0115672018295247240426055330. Online ahead of print.ABSTRACTTuberculosis (TB) continues to pose a significant global health threat, with millions of new infections recorded annually. Current treatment strategies, such as Directly Observed Treatment (DOT), face challenges, including patient non-compliance and the emergence of drug-resistant TB strains. In response to these obstacles, innovative approaches utilizing inorganic/metallic nanomaterials have been developed to enhance drug delivery to target alveolar macrophages, where Mycobacterium tuberculosis resides. These nanomateria...
Source: Current Drug Delivery - May 2, 2024 Category: Drugs & Pharmacology Authors: Debabrata Ghosh Dastidar Arnab Roy Gourav Ghosh Supratim Mandal Source Type: research
Multidrug-Resistant tuberculosis
The objective of this review is to increase awareness of the need for rapid and precise detection of MDR-TB cases to decrease morbidity and mortality of this infectious disease worldwide.PMID:38697459 | DOI:10.1016/j.cca.2024.119701 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - May 2, 2024 Category: Chemistry Authors: Dika Apriliana Wulandari Yeni Wahyuni Hartati Abdullahi Umar Ibrahim Dian Ayu Eka Pitaloka None Irkham Source Type: research
Pyridinium-Yne Click Polymerization: A Facile Strategy toward Functional Poly(Vinylpyridinium Salt)s with Multidrug-Resistant Bacteria Killing Ability
In this study, we demonstrate a simple and efficient strategy for synthesizing functional poly(vinylpyridinium salt)s via pyridinium-yne click polymerization. This click polymerization could proceed with high atom economy under mild conditions without any external catalyst, yielding soluble and thermally stable poly(vinylpyridinium salt)s with satisfactory molecular weights and well-defined structures in excellent yields. Additionally, the incorporation of luminescent units such as fluorene, tetraphenylethylene, and triphenylamine into the polymer backbone confers excellent aggregation-enhanced emission properties upon the...
Source: Angewandte Chemie - May 2, 2024 Category: Chemistry Authors: Benzhao He Ying Li Meng Li Miaomiao Kang Xinyue Liu Jiachang Huang Dong Wang Jacky W Y Lam Ben Zhong Tang Source Type: research
Multidrug resistance in < em > Salmonella < /em > isolates of swine origin: mobile genetic elements and plasmids associated with cephalosporin resistance with potential transmission to humans
Appl Environ Microbiol. 2024 May 2:e0026424. doi: 10.1128/aem.00264-24. Online ahead of print.ABSTRACTThe emergence of foodborne Salmonella strains carrying antimicrobial resistance (AMR) in mobile genetic elements (MGE) is a significant public health threat in a One Health context requiring continuous surveillance. Resistance to ciprofloxacin and cephalosporins is of particular concern. Since pigs are a relevant source of foodborne Salmonella for human beings, we studied transmissible AMR genes and MGE in a collection of 83 strains showing 9 different serovars and 15 patterns of multidrug resistant (MDR) previously isolat...
Source: Applied and Environmental Microbiology - May 2, 2024 Category: Microbiology Authors: V Garrido A Arrieta-Gisasola L Migura-Garc ía L Laorden M J Grill ó Source Type: research
Thought on “Isolation and Phenotypic Characterization of Virulent Bacteriophages Against Multidrug-Resistant Escherichia Coli and Its Phage-Resistant Variant from Sewage Sources” [Letter]
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - May 2, 2024 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
Bedaquiline, pretomanid and linezolid in multidrug-resistant and pre-extensively drug-resistant tuberculosis in refugees from Ukraine and Somalia in Germany
Extract
According to the World Health Organization (WHO) 2023 tuberculosis (TB) report, in the European Union region there are approximately 200 000 TB cases per year, among which 30 000 are rifampicin resistant (RR) with treatment success rates of 57% [1], indicating a considerable gap from the United Nations' goal of an 80% reduction by 2030. In 2022, the WHO guideline for the treatment of multidrug-resistant (MDR) TB recommended as new first-line regimen for MDR-TB (resistance to at least isoniazid and rifampicin [2]) bedaquiline, pretomanid, linezolid and moxifloxacin (BPaLM), and for pre-extensively drug-resistant tub...
Source: European Respiratory Journal - May 2, 2024 Category: Respiratory Medicine Authors: Trauth, J., Kantelhardt, V., Usenko, B., Knipper, M., Kuhns, M., Friesen, I., Herold, S. Tags: Research Letters Source Type: research
Raw meat-based diet for pets: a neglected source of human exposure to Salmonella and pathogenic Escherichia coli clones carrying mcr, Portugal, September 2019 to January 2020
ConclusionSome RMBDs from European brands available in Portugal can be a vehicle for clinically relevant MDRSalmonella and pathogenicE. coli clones carrying genes encoding resistance to the last-line antibiotic colistin. Proactive actions within the One Health context, spanning regulatory, pet-food industry and consumer levels, are needed to mitigate these public health risks. (Source: Eurosurveillance)
Source: Eurosurveillance - May 2, 2024 Category: Infectious Diseases Authors: Marisa Ribeiro-Almeida, Joana Mour ão, Mafalda Magalhães, Ana R Freitas, Carla Novais, Luísa Peixe and Patrícia Antunes Source Type: research
Practical Synthesis of Isoindolines Yields Potent Colistin Potentiators in Multidrug-Resistant Acinetobacter baumannii
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4OB00463A, CommunicationSomnath Dutta, Samantha Eyolfson, Yuhang Zhou, Yuefeng Gao, Xiang Wang An efficient and practical one-pot synthesis of isoindolines from readily available starting materials was achieved under mild conditions by implementing isoindole umpolung strategy. A variety of isoindolines were prepared with... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - May 1, 2024 Category: Molecular Biology Authors: Somnath Dutta Source Type: research
