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Detoxification of tetracycline and synthetic dyes by a newly characterized Lentinula edodes laccase, and safety assessment using proteomic analysis
This study showed that the extracellular fungal laccase from L. edodes could effectively degrade tetracycline (TET) and the synthetic dye Acid Green 25 (AG). The growth inhibition of Escherichia coli and Bacillus subtilis by TET revealed that the antimicrobial activity was significantly reduced after treatment with the laccase-HBT system. 16 transformation products of TET were identified by UPLC-MS-TOF during the laccase-HBT oxidation process. Gas chromatography-mass spectrometry (GC-MS) analysis revealed that LeLac12 could completely mineralize ring-cleavage products. LeLac12 completely catalyzed 50 mg/L TET within 4 h by...
Source: Ecotoxicology and Environmental Safety - April 18, 2024 Category: Environmental Health Authors: Shuxue Zhao Xiaohang Li Xingdong Yao Xuyang Liu Chao Pan Lizhong Guo Jie Bai Tiantian Chen Hao Yu Chunhui Hu Source Type: research

Oleanolic acid: an antimycobacterial component of < em > Syzygium aromaticum < /em > L. and inhibitor of efflux mediated drug resistance
Nat Prod Res. 2024 Apr 18:1-7. doi: 10.1080/14786419.2024.2343916. Online ahead of print.ABSTRACTOleanolic acid (OA) was isolated from Syzygium aromaticum L. buds, and structurally characterised using different spectroscopic techniques; MS, IR,1H/13C-NMR and 2D NMR experiments. The antimycobacterial activity according to a resazurin microtiter assay (REMA) showed important inhibitory effect of OA on the virulent H37Rv strain, with the lowest minimum concentration of 50 µg/mL, compared to other fractions. Molecular docking of OA with BacA drug efflux pump resulted in good binding affinity of hydrophobic interaction type. T...
Source: Natural Product Research - April 18, 2024 Category: Biochemistry Authors: Yassine El Ghallab Mohamed Dakir Achraf Aainouss My Driss El Messaoudi Sanae Derfoufi Source Type: research

Enterotoxigenic Staphylococcus aureus in Brazilian artisanal cheeses: Occurrence, counts, phenotypic and genotypic profiles
Food Microbiol. 2024 Aug;121:104531. doi: 10.1016/j.fm.2024.104531. Epub 2024 Apr 3.ABSTRACTThe present study aimed to assess the occurrence and counts of Staphylococcus aureus in Brazilian artisanal cheeses (BAC) produced in five regions of Brazil: Coalho and Manteiga (Northeast region); Colonial and Serrano (South); Caipira (Central-West); Marajó (North); and Minas Artisanal cheeses, from Araxá, Campos das Vertentes, Cerrado, Serro and Canastra microregions (Southeast). The resistance to chlorine-based sanitizers, ability to attach to stainless steel surfaces, and antibiogram profile of a large set of S. aureus strains...
Source: Food Microbiology - April 18, 2024 Category: Food Science Authors: Larissa P Margalho Juliana S Gra ça Bruna A Kamimura Sarah H I Lee H éctor D S Canales Alexandra I A Chincha Magdevis Y R Caturla Ramon P Brex ó Aline Crucello Ver ônica O Alvarenga Adriano G Cruz Carlos Augusto F Oliveira Anderson S Sant'Ana Source Type: research

Viruses, Vol. 16, Pages 627: Trends in and Risk Factors for Drug Resistance in Mycobacterium tuberculosis in HIV-Infected Patients
Zhaoqin Zhu Yinzhong Shen Trends in and risk factors for drug resistance in Mycobacterium tuberculosis (M. tuberculosis) in human immunodeficiency virus (HIV)-infected patients with active tuberculosis were analyzed. The clinical data of M. tuberculosis and HIV-coinfected patients treated at the Shanghai Public Health Clinical Center between 2010 and 2022 were collected. The diagnosis of tuberculosis was confirmed by solid or liquid culture. The phenotypic drug susceptibility test was carried out via the proportional method, and the resistance to first-line and second-line drugs was analyzed. Logistic regression an...
Source: Viruses - April 18, 2024 Category: Virology Authors: Xiaoqin Le Xueqin Qian Li Liu Jianjun Sun Wei Song Tangkai Qi Zhenyan Wang Yang Tang Shuibao Xu Junyang Yang Jiangrong Wang Jun Chen Renfang Zhang Zhaoqin Zhu Yinzhong Shen Tags: Article Source Type: research

The emergence of highly resistant and hypervirulent Klebsiella pneumoniae CC14 clone in a tertiary hospital over 8 years
ConclusionsOverall, these results demonstrate the clinical significance of ST2096 clones and illustrate the rapid evolution of an emerging hypervirulent and MDRK. pneumoniae in a clinical setting. (Source: Genome Medicine)
Source: Genome Medicine - April 18, 2024 Category: Genetics & Stem Cells Source Type: research

Megaplasmid Dissemination in Multidrug-Resistant Salmonella Serotypes from Backyard and Commercial Broiler Production Systems in the Southeastern United States
Foodborne Pathogens and Disease, Ahead of Print. (Source: Foodborne Pathogens and Disease)
Source: Foodborne Pathogens and Disease - April 18, 2024 Category: Food Science Authors: Jessica L. Parzygnat Rocio Crespo Mary Fosnaught Muhammed Muyyarrikkandy Dawn Hull Lyndy Harden Siddhartha Thakur Source Type: research

Multidrug-resistant pathogens and ventilator-associated pneumonia in critically ill COVID-19 and non-COVID-19 patients: a prospective observational monocentric comparative study
The COVID-19 pandemic has increased the incidence of ventilator-associated pneumonia (VAP) among critically ill patients. However, a comparison of VAP incidence in COVID-19 and non-COVID-19 cohorts, particular... (Source: Respiratory Research)
Source: Respiratory Research - April 18, 2024 Category: Respiratory Medicine Authors: Giorgia Montrucchio, Eleonora Balzani, Gabriele Sales, Anna Vaninetti, Francesca Grillo, Anna Chiara Trompeo, Marinella Zanierato, Vito Fanelli, Silvia Corcione, Francesco Giuseppe De Rosa, Antonio Curtoni, Cristina Costa and Luca Brazzi Tags: Research Source Type: research