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Multidrug ‐resistant Stenotrophomonas maltophilia in residential aged care facilities: An emerging threat
This study marks the first assessment of the prevalence, resistome, and genomic characteristics of multidrug-resistant (MDR)Stenotrophomonas maltophilia in residential aged care facilities. MDRS. maltophilia were found in all sampled facilities, with colistin non-wild type and trimethoprim-sulfamethoxazole resistant isolates recovered. Many isolates also exhibited high tolerance to triclosan and benzalkonium chloride. Notably, our findings indicate the continued emergence ofS. maltophilia, with lineages not previously identified in Australia observed in this study. This underscores the urgent need for comprehensive surveil...
Source: MicrobiologyOpen - April 29, 2024 Category: Microbiology Authors: Sylvia A. Sapula, Bradley J. Hart, Naomi L. Siderius, Anteneh Amsalu, Jack M. Blaikie, Henrietta Venter Tags: ORIGINAL ARTICLE Source Type: research

A small step towards an important goal: fragment screen of the c-di-AMP-synthesizing enzyme CdaA
CdaA is the most widespread diadenylate cyclase in many bacterial species, including several multidrug-resistant human pathogens. The enzymatic product of CdaA, cyclic di-AMP, is a secondary messenger that is essential for the viability of many bacteria. Its absence in humans makes CdaA a very promising and attractive target for the development of new antibiotics. Here, the structural results are presented of a crystallographic fragment screen against CdaA from Listeria monocytogenes, a saprophytic Gram-positive bacterium and an opportunistic food-borne pathogen that can cause listeriosis in humans and animals. Two of the ...
Source: Acta Crystallographica Section D - April 29, 2024 Category: Biochemistry Authors: Neumann, P. Heidemann, J.L. Wollenhaupt, J. Dickmanns, A. Agthe, M. Weiss, M.S. Ficner, R. Tags: crystallographic fragment screening CdaA Listeria monocytogenes cyclic di-AMP drug design research papers Source Type: research

Biofilm-disrupting effects of phage endolysins LysAm24, LysAp22, LysECD7, and LysSi3: breakdown the matrix
AbstractThe ability of most opportunistic bacteria to form biofilms, coupled with antimicrobial resistance, hinder the efforts to control widespread infections, resulting in high risks of negative outcomes and economic costs. Endolysins are promising compounds that efficiently combat bacteria, including multidrug-resistant strains and biofilms, without a low probability of subsequent emergence of stable endolysin-resistant phenotypes. However, the details of antibiofilm effects of these enzymes are poorly understood. To elucidate the interactions of bacteriophage endolysins LysAm24, LysAp22, LysECD7, and LysSi3 with bacter...
Source: World Journal of Microbiology and Biotechnology - April 29, 2024 Category: Microbiology Source Type: research

Detection of metallo-beta-lactamase-producing genes bla SPM and bla NDM in Pseudomonas aeruginosa isolated from wastewater in Southern Brazil
The objective of this study was to investigate genes encoding metallo-beta-lactamases (MBLs), which confer resistance to carbapenems, in wastewater. Fifteen isolates of P. aeruginosa were collected for five months from samples obtained from a municipal wastewater treatment plant in Rio Grande do Sul. These isolates were subjected to disk diffusion testing using 10 different antimicrobials. Phenotypic enzymatic tests for MBLs were conducted, and positive isolates underwent DNA extraction and gene detection using the polymerase chain reaction. The resistance rate to ceftazidime was 100%, cefepime 73.3%, piperacillin-tazobact...
Source: Journal of Water and Health - April 28, 2024 Category: Environmental Health Authors: Vin ícius Monteagudo de Barros Bruna Seixas da Rocha Jaqueline Rhoden Jana ína Franciele Stein Simone Ulrich Picoli Caroline Rigotto Source Type: research

Detection of Virulence Genes in Pseudomonas aeruginosa Isolates by Polymerase Chain Reaction and Investigation of High-Risk Clones by Matrix Assisted Laser Desorption/ Ionization Time-of-Flight Mass Spectrometer Method
Mikrobiyol Bul. 2024 Apr;58(2):135-147. doi: 10.5578/mb.202498112.ABSTRACTPseudomonas aeruginosa is a non-fermentative gram-negative bacillus. Many virulence factors play a role in the pathogenesis of P.aeruginosa. The aim of this study was to early detection of ST111, ST175, ST235, ST253, ST395 which are named high-risk clones with increased epidemic potential due to multidrug resistance in P.aeruginosa isolates by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) method and to evaluate the relationship between high-risk clones and the presence of P.aeruginosa virulence factors an...
Source: Mikrobiyoloji Bulteni - April 27, 2024 Category: Microbiology Authors: G ülşah Karacan Temür Yeliz Tanriverdi Çayci Asuman Birinci Source Type: research

Biomedical and Biotechnological Potential of Animal Venoms: Bothrops Snake Venoms and their Antimicrobial Applications
Curr Med Chem. 2024 Apr 26. doi: 10.2174/0109298673290981240416070550. Online ahead of print.ABSTRACTThe pursuit of novel treatment alternatives to address the accumulated resistance to antimicrobials over the years has prompted the scientific community to explore biodiversity, particularly animal venom, as a potential source of new antimicrobial drugs. Snake venoms, with their complex mixtures of components, are particularly promising targets for investigation in this regard. The search for novel molecules exhibiting antimicrobial activity against multidrug-resistant strains is of paramount importance for public health an...
Source: Current Medicinal Chemistry - April 27, 2024 Category: Chemistry Authors: Raissa Reimann Breno Barreto Filippo Romano Jade Medeiros Bruna C Camargo Josiel N da Silva Ana Luiza B Soares Mateus F de Souza Jamile M Macedo Anderson M Kayano Juliana P Zuliani Ana N de Oliveira Saulo L da Silva Rafaela Diniz-Sousa Andreimar M Soares Source Type: research

A Pharmacovigilance Study of adverse events associated with polymyxins based on the U.S. Food and Drug Administration adverse event reporting system (FAERS) database
CONCLUSIONS: Patients treated with colistin displayed a higher potential risk of nephrotoxicity but a lower risk of neurotoxicity when compared to those treated with PMB. Clinicians should be vigilant in monitoring the AEs of hyperpigmentation disorders induced by PMB, as there have been reported cases associated with its use, whereas no instances of this AE were reported among colistin-treated patients. Nevertheless, further research, especially with larger sample sizes, is imperative to validate these findings.PMID:38676603 | DOI:10.1080/14740338.2024.2348610 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - April 27, 2024 Category: Drugs & Pharmacology Authors: Tingxi Wu Yanfeng Shi Chang Xu Bin Zhu Dandan Li Zhe Li Zhigang Zhao Yang Zhang Source Type: research