Comparative analysis of the antimicrobial resistance and virulence traits in ESBL-producing-Klebsiella pneumoniae ST307 strains colonizing the gastrointestinal tract and causing a fatal bloodstream infection in a leukemia patient
Infect Genet Evol. 2024 Apr 21:105598. doi: 10.1016/j.meegid.2024.105598. Online ahead of print.ABSTRACTKlebsiella pneumoniae is an opportunistic pathogen that can colonize the gastrointestinal tract (GIT) of humans. The mechanisms underlying the successful translocation of this pathogen to cause extra-intestinal infections remain unknown, although virulence and antimicrobial resistance traits likely play significant roles in the establishment of infections. We investigated K. pneumoniae strains isolated from GIT colonization (strains Kp_FZcol-1, Kp_FZcol-2 and Kp_FZcro-1) and from a fatal bloodstream infection (strain Kp_...
Source: Infection, Genetics and Evolution - April 23, 2024 Category: Genetics & Stem Cells Authors: Luana Boff Humberl ânia de Sousa Duarte Gabriela Bergiante Kraychete Gabriel Taddeucci-Rocha Bianca Diniz Oliveira Rodolpho Mattos Albano Ana Paula D'Alincourt Carvalho-Assef Silvana Vargas Superti Ianick Souto Martins Renata Cristina Pic ão Source Type: research
Application of Mono and Trinuclear Cyclometalated Iridium (III) Complexes in Differential Bacterial Imaging and Antimicrobial Photodynamic therapy
Chemistry. 2024 Apr 23:e202400646. doi: 10.1002/chem.202400646. Online ahead of print.ABSTRACTThe application of transition metal complexes for antimicrobial photodynamic therapy (PDT) has emerged as an attractive alternative in mitigating a broad range of bacterial pathogens, including multidrug-resistant pathogens. In view of their photostability, long excited-state lifetimes, and tunable emission properties, transition metal complexes also contribute as bioimaging agents. In the present work, we designed mono and trinuclear cyclometalated iridium(III) complexes to explore their imaging application and antibacterial pote...
Source: Chemistry - April 23, 2024 Category: Chemistry Authors: Bishnu Das Prakash Biswas Amirul Islam Mallick Parna Gupta Source Type: research
Development of an efficient liposomal DOX delivery formulation for HCC therapy by targeting CK2 α
Biotechnol J. 2024 Apr;19(4):e2400050. doi: 10.1002/biot.202400050.ABSTRACTHepatocellular carcinoma (HCC) is a digestive tract cancer with high mortality and poor prognosis, especially in China. Current chemotherapeutic drugs lead to poor prognosis, low efficacy, and high side effects due to weak targeting specificity and rapidly formed multidrug resistance (MDR). Based on the previous studies on the doxorubicin (DOX) formulation for cancer targeting therapy, we developed a novel DOX delivery formulation for the targeting chemotherapy of HCC and DOX resistant HCC. HCSP4 was previously screened and casein kinase 2α (CK2α)...
Source: Biotechnology Journal - April 23, 2024 Category: Biotechnology Authors: Ruixia Zhao Sinan Cheng Xue Bai Danying Zhang Hongming Fang Wanlin Che Wenxuan Zhang Yujuan Zhou Wei Duan Qiumin Liang Li Xiao Guochao Nie Yingchun Hou Source Type: research
Recurrent Chagas' disease meningomyelitis in an HIV-infected patient
We report a 59-year-old man native from the Northeast region of Brazil, with a second episode of subacute chagasic meningomyelitis. He had long-term multidrug-resistant HIV and had abandoned combined antiretroviral therapy (CD4+ lymphocyte count, 16 cells/mm³, and HIV viral load 169 403 copies/mL). He initially received benznidazole but switched to nifurtimox after developing myelotoxicity. He was discharged home having made a partial neurological improvement. Chagas' disease should be included in the differential diagnosis of meningomyelitis in people living with HIV/AIDS who are from endemic areas of this parasitic dise...
Source: Practical Neurology - April 23, 2024 Category: Neurology Authors: Igor Melo de Almeida Aline Borges Moreira da Rocha Jos é Angelo Lauletta Lindoso Vera L úcia Teixeira de Freitas Augusto Cp Oliveira Jose E Vidal Source Type: research
Comparative analysis of the antimicrobial resistance and virulence traits in ESBL-producing-Klebsiella pneumoniae ST307 strains colonizing the gastrointestinal tract and causing a fatal bloodstream infection in a leukemia patient
Infect Genet Evol. 2024 Apr 21:105598. doi: 10.1016/j.meegid.2024.105598. Online ahead of print.ABSTRACTKlebsiella pneumoniae is an opportunistic pathogen that can colonize the gastrointestinal tract (GIT) of humans. The mechanisms underlying the successful translocation of this pathogen to cause extra-intestinal infections remain unknown, although virulence and antimicrobial resistance traits likely play significant roles in the establishment of infections. We investigated K. pneumoniae strains isolated from GIT colonization (strains Kp_FZcol-1, Kp_FZcol-2 and Kp_FZcro-1) and from a fatal bloodstream infection (strain Kp_...
Source: Infection, Genetics and Evolution - April 23, 2024 Category: Genetics & Stem Cells Authors: Luana Boff Humberl ânia de Sousa Duarte Gabriela Bergiante Kraychete Gabriel Taddeucci-Rocha Bianca Diniz Oliveira Rodolpho Mattos Albano Ana Paula D'Alincourt Carvalho-Assef Silvana Vargas Superti Ianick Souto Martins Renata Cristina Pic ão Source Type: research
Application of Mono and Trinuclear Cyclometalated Iridium (III) Complexes in Differential Bacterial Imaging and Antimicrobial Photodynamic therapy
Chemistry. 2024 Apr 23:e202400646. doi: 10.1002/chem.202400646. Online ahead of print.ABSTRACTThe application of transition metal complexes for antimicrobial photodynamic therapy (PDT) has emerged as an attractive alternative in mitigating a broad range of bacterial pathogens, including multidrug-resistant pathogens. In view of their photostability, long excited-state lifetimes, and tunable emission properties, transition metal complexes also contribute as bioimaging agents. In the present work, we designed mono and trinuclear cyclometalated iridium(III) complexes to explore their imaging application and antibacterial pote...
Source: Chemistry - April 23, 2024 Category: Chemistry Authors: Bishnu Das Prakash Biswas Amirul Islam Mallick Parna Gupta Source Type: research
Development of an efficient liposomal DOX delivery formulation for HCC therapy by targeting CK2 α
Biotechnol J. 2024 Apr;19(4):e2400050. doi: 10.1002/biot.202400050.ABSTRACTHepatocellular carcinoma (HCC) is a digestive tract cancer with high mortality and poor prognosis, especially in China. Current chemotherapeutic drugs lead to poor prognosis, low efficacy, and high side effects due to weak targeting specificity and rapidly formed multidrug resistance (MDR). Based on the previous studies on the doxorubicin (DOX) formulation for cancer targeting therapy, we developed a novel DOX delivery formulation for the targeting chemotherapy of HCC and DOX resistant HCC. HCSP4 was previously screened and casein kinase 2α (CK2α)...
Source: Biotechnology Journal - April 23, 2024 Category: Biotechnology Authors: Ruixia Zhao Sinan Cheng Xue Bai Danying Zhang Hongming Fang Wanlin Che Wenxuan Zhang Yujuan Zhou Wei Duan Qiumin Liang Li Xiao Guochao Nie Yingchun Hou Source Type: research
Blockade of neutrophil extracellular trap components ameliorates cholestatic liver disease in Mdr2 (Abcb4) knockout mice
J Autoimmun. 2024 Apr 22;146:103229. doi: 10.1016/j.jaut.2024.103229. Online ahead of print.ABSTRACTPrimary sclerosing cholangitis (PSC) is an (auto)immune-mediated cholestatic liver disease with a yet unclear etiology. Increasing evidence points to an involvement of neutrophils in chronic liver inflammation and cirrhosis but also liver repair. Here, we investigate the role of the neutrophil extracellular trap (NET) component myeloperoxidase (MPO) and the therapeutic potential of DNase I and of neutrophil elastase (NE) inhibitor GW311616A on disease outcome in the multidrug resistance 2 knockout (Mdr2-/-) mouse, a PSC anim...
Source: Journal of Autoimmunity - April 23, 2024 Category: Allergy & Immunology Authors: Edith Hintermann Camilla Tondello Sina Fuchs Monika Bayer Josef M Pfeilschifter Richard Taubert Martin Mollenhauer Roland P J Oude Elferink Michael P Manns Urs Christen Source Type: research
Recurrent Chagas' disease meningomyelitis in an HIV-infected patient
We report a 59-year-old man native from the Northeast region of Brazil, with a second episode of subacute chagasic meningomyelitis. He had long-term multidrug-resistant HIV and had abandoned combined antiretroviral therapy (CD4+ lymphocyte count, 16 cells/mm³, and HIV viral load 169 403 copies/mL). He initially received benznidazole but switched to nifurtimox after developing myelotoxicity. He was discharged home having made a partial neurological improvement. Chagas' disease should be included in the differential diagnosis of meningomyelitis in people living with HIV/AIDS who are from endemic areas of this parasitic dise...
Source: Practical Neurology - April 23, 2024 Category: Neurology Authors: Igor Melo de Almeida Aline Borges Moreira da Rocha Jos é Angelo Lauletta Lindoso Vera L úcia Teixeira de Freitas Augusto Cp Oliveira Jose E Vidal Source Type: research
Comparative analysis of the antimicrobial resistance and virulence traits in ESBL-producing-Klebsiella pneumoniae ST307 strains colonizing the gastrointestinal tract and causing a fatal bloodstream infection in a leukemia patient
Infect Genet Evol. 2024 Apr 21:105598. doi: 10.1016/j.meegid.2024.105598. Online ahead of print.ABSTRACTKlebsiella pneumoniae is an opportunistic pathogen that can colonize the gastrointestinal tract (GIT) of humans. The mechanisms underlying the successful translocation of this pathogen to cause extra-intestinal infections remain unknown, although virulence and antimicrobial resistance traits likely play significant roles in the establishment of infections. We investigated K. pneumoniae strains isolated from GIT colonization (strains Kp_FZcol-1, Kp_FZcol-2 and Kp_FZcro-1) and from a fatal bloodstream infection (strain Kp_...
Source: Infection, Genetics and Evolution - April 23, 2024 Category: Genetics & Stem Cells Authors: Luana Boff Humberl ânia de Sousa Duarte Gabriela Bergiante Kraychete Gabriel Taddeucci-Rocha Bianca Diniz Oliveira Rodolpho Mattos Albano Ana Paula D'Alincourt Carvalho-Assef Silvana Vargas Superti Ianick Souto Martins Renata Cristina Pic ão Source Type: research
Development of an efficient liposomal DOX delivery formulation for HCC therapy by targeting CK2 α
Biotechnol J. 2024 Apr;19(4):e2400050. doi: 10.1002/biot.202400050.ABSTRACTHepatocellular carcinoma (HCC) is a digestive tract cancer with high mortality and poor prognosis, especially in China. Current chemotherapeutic drugs lead to poor prognosis, low efficacy, and high side effects due to weak targeting specificity and rapidly formed multidrug resistance (MDR). Based on the previous studies on the doxorubicin (DOX) formulation for cancer targeting therapy, we developed a novel DOX delivery formulation for the targeting chemotherapy of HCC and DOX resistant HCC. HCSP4 was previously screened and casein kinase 2α (CK2α)...
Source: Biotechnology Journal - April 23, 2024 Category: Biotechnology Authors: Ruixia Zhao Sinan Cheng Xue Bai Danying Zhang Hongming Fang Wanlin Che Wenxuan Zhang Yujuan Zhou Wei Duan Qiumin Liang Li Xiao Guochao Nie Yingchun Hou Source Type: research
Recurrent Chagas' disease meningomyelitis in an HIV-infected patient
We report a 59-year-old man native from the Northeast region of Brazil, with a second episode of subacute chagasic meningomyelitis. He had long-term multidrug-resistant HIV and had abandoned combined antiretroviral therapy (CD4+ lymphocyte count, 16 cells/mm³, and HIV viral load 169 403 copies/mL). He initially received benznidazole but switched to nifurtimox after developing myelotoxicity. He was discharged home having made a partial neurological improvement. Chagas' disease should be included in the differential diagnosis of meningomyelitis in people living with HIV/AIDS who are from endemic areas of this parasitic dise...
Source: Practical Neurology - April 23, 2024 Category: Neurology Authors: Igor Melo de Almeida Aline Borges Moreira da Rocha Jos é Angelo Lauletta Lindoso Vera L úcia Teixeira de Freitas Augusto Cp Oliveira Jose E Vidal Source Type: research
Development of an efficient liposomal DOX delivery formulation for HCC therapy by targeting CK2 α
Biotechnol J. 2024 Apr;19(4):e2400050. doi: 10.1002/biot.202400050.ABSTRACTHepatocellular carcinoma (HCC) is a digestive tract cancer with high mortality and poor prognosis, especially in China. Current chemotherapeutic drugs lead to poor prognosis, low efficacy, and high side effects due to weak targeting specificity and rapidly formed multidrug resistance (MDR). Based on the previous studies on the doxorubicin (DOX) formulation for cancer targeting therapy, we developed a novel DOX delivery formulation for the targeting chemotherapy of HCC and DOX resistant HCC. HCSP4 was previously screened and casein kinase 2α (CK2α)...
Source: Biotechnology Journal - April 23, 2024 Category: Biotechnology Authors: Ruixia Zhao Sinan Cheng Xue Bai Danying Zhang Hongming Fang Wanlin Che Wenxuan Zhang Yujuan Zhou Wei Duan Qiumin Liang Li Xiao Guochao Nie Yingchun Hou Source Type: research
Recurrent Chagas' disease meningomyelitis in an HIV-infected patient
We report a 59-year-old man native from the Northeast region of Brazil, with a second episode of subacute chagasic meningomyelitis. He had long-term multidrug-resistant HIV and had abandoned combined antiretroviral therapy (CD4+ lymphocyte count, 16 cells/mm³, and HIV viral load 169 403 copies/mL). He initially received benznidazole but switched to nifurtimox after developing myelotoxicity. He was discharged home having made a partial neurological improvement. Chagas' disease should be included in the differential diagnosis of meningomyelitis in people living with HIV/AIDS who are from endemic areas of this parasitic dise...
Source: Practical Neurology - April 23, 2024 Category: Neurology Authors: Igor Melo de Almeida Aline Borges Moreira da Rocha Jos é Angelo Lauletta Lindoso Vera L úcia Teixeira de Freitas Augusto Cp Oliveira Jose E Vidal Source Type: research
Development of an efficient liposomal DOX delivery formulation for HCC therapy by targeting CK2 α
Biotechnol J. 2024 Apr;19(4):e2400050. doi: 10.1002/biot.202400050.ABSTRACTHepatocellular carcinoma (HCC) is a digestive tract cancer with high mortality and poor prognosis, especially in China. Current chemotherapeutic drugs lead to poor prognosis, low efficacy, and high side effects due to weak targeting specificity and rapidly formed multidrug resistance (MDR). Based on the previous studies on the doxorubicin (DOX) formulation for cancer targeting therapy, we developed a novel DOX delivery formulation for the targeting chemotherapy of HCC and DOX resistant HCC. HCSP4 was previously screened and casein kinase 2α (CK2α)...
Source: Biotechnology Journal - April 23, 2024 Category: Biotechnology Authors: Ruixia Zhao Sinan Cheng Xue Bai Danying Zhang Hongming Fang Wanlin Che Wenxuan Zhang Yujuan Zhou Wei Duan Qiumin Liang Li Xiao Guochao Nie Yingchun Hou Source Type: research
