Characterization of genes related to the efflux pump and porin in multidrug-resistant Escherichia coli strains isolated from patients with COVID-19 after secondary infection
This study aimed to determine the antimicrobial resistance profi... (Source: BMC Microbiology)
Source: BMC Microbiology - April 10, 2024 Category: Microbiology Authors: Aryan R. Ganjo, Salah Tofik Jalal Balaky, Ahang Hasan Mawlood, Sakar B. Smail and Nazar P. Shabila Tags: Research Source Type: research
Clinical manifestations, antimicrobial resistance and genomic feature analysis of multidrug-resistant Elizabethkingia strains
Elizabethkingia is emerging as an opportunistic pathogen in humans. The aim of this study was to investigate the clinical epidemiology, antimicrobial susceptibility, virulence factors, and genome features of Eliz... (Source: Annals of Clinical Microbiology and Antimicrobials)
Source: Annals of Clinical Microbiology and Antimicrobials - April 10, 2024 Category: Microbiology Authors: Chongyang Wu, Li Xiong, Quanfeng Liao, Weili Zhang, Yuling Xiao and Yi Xie Tags: Research Source Type: research
Poor performance of paired tests of latent tuberculosis in highly immune-compromised individuals exposed to multidrug-resistant tuberculosis: time for new diagnostic markers
ERJ Open Res. 2024 Apr 8;10(2):00732-2023. doi: 10.1183/23120541.00732-2023. eCollection 2024 Mar.ABSTRACTGuideline-based recommendations for diagnosis of latent TB in highly immune suppressed populations are difficult to interpret and poorly characterised. More accurate biomarkers independent of T-cell functions are urgently required. https://bit.ly/41P8vTa.PMID:38590937 | PMC:PMC11000274 | DOI:10.1183/23120541.00732-2023 (Source: Cell Research)
Source: Cell Research - April 9, 2024 Category: Cytology Authors: Geoffrey Eather Malcolm Wilson Celine Goffinet Elizabeth Ryan Source Type: research
Schiff bases and their metal complexes to target and overcome (multidrug) resistance in cancer
Eur J Med Chem. 2024 Mar 29;270:116363. doi: 10.1016/j.ejmech.2024.116363. Online ahead of print.ABSTRACTOvercoming multidrug resistance (MDR) is one of the major challenges in cancer therapy. In this respect, Schiff base-related compounds (bearing a R1R2CNR3 bond) gained high interest during the past decades. Schiff bases are considered privileged ligands for various reasons, including the easiness of their preparation and the possibility to form complexes with almost all transition metal ions. Schiff bases and their metal complexes exhibit many types of biological activities and are used for the treatment and diagnosis o...
Source: European Journal of Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Ana Podolski-Reni ć Ana Čipak Gašparović Andreia Valente Óscar López Julia H Bormio Nunes Christian R Kowol Petra Heffeter Nenad R Filipovi ć Source Type: research
The virtue of training: extending phage host spectra against vancomycin-resistant < em > Enterococcus faecium < /em > strains using the Appelmans method
Antimicrob Agents Chemother. 2024 Apr 9:e0143923. doi: 10.1128/aac.01439-23. Online ahead of print.ABSTRACTPhage therapy has (re)emerged as a serious possibility for combating multidrug-resistant bacterial infections, including those caused by vancomycin-resistant Enterococcus faecium strains. These opportunistic pathogens belong to a specific clonal complex 17, against which relatively few phages have been screened. We isolated a collection of 21 virulent phages growing on these vancomycin-resistant isolates. Each of these phages harbored a typical narrow plaquing host range, lysing at most 5 strains and covering together...
Source: Antimicrobial Agents and Chemotherapy - April 9, 2024 Category: Microbiology Authors: Julien Lossouarn Elsa Beurrier Astrid Bouteau Elisabeth Moncaut Maria Sir Silmane He ïdi Portalier Asma Zouari Vincent Cattoir Pascale Serror Marie-Agn ès Petit Source Type: research
A Multidrug-Resistant Extended-Spectrum Beta-Lactamase (ESBL)-Producing Enterobacter hormaechei Strain from Mixed Sprouts
Curr Microbiol. 2024 Apr 9;81(5):131. doi: 10.1007/s00284-024-03663-3.ABSTRACTFresh vegetables can harbor antibiotic-resistant bacteria, including extended-spectrum β-lactamase (ESBL)-producing Enterobacterales. Enterobacter hormaechei is a bacterium belonging to the Enterobacterales order and the most commonly identified nosocomial pathogen of Enterobacter cloacae complex. The purpose of this study was to characterize a multi-drug resistant ESBL-producing E. hormaechei strain isolated from a sample of mixed sprouts. Vegetable samples were pre-enriched in buffered peptone water, followed by enrichment in Enterobacteria En...
Source: Current Microbiology - April 9, 2024 Category: Microbiology Authors: Elizabeth A Leighton Chelsea N Gale En Huang Xu Yang Erin L DiCaprio Xinhui Li Source Type: research
Schiff bases and their metal complexes to target and overcome (multidrug) resistance in cancer
Eur J Med Chem. 2024 Mar 29;270:116363. doi: 10.1016/j.ejmech.2024.116363. Online ahead of print.ABSTRACTOvercoming multidrug resistance (MDR) is one of the major challenges in cancer therapy. In this respect, Schiff base-related compounds (bearing a R1R2CNR3 bond) gained high interest during the past decades. Schiff bases are considered privileged ligands for various reasons, including the easiness of their preparation and the possibility to form complexes with almost all transition metal ions. Schiff bases and their metal complexes exhibit many types of biological activities and are used for the treatment and diagnosis o...
Source: European Journal of Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Ana Podolski-Reni ć Ana Čipak Gašparović Andreia Valente Óscar López Julia H Bormio Nunes Christian R Kowol Petra Heffeter Nenad R Filipovi ć Source Type: research
The virtue of training: extending phage host spectra against vancomycin-resistant < em > Enterococcus faecium < /em > strains using the Appelmans method
Antimicrob Agents Chemother. 2024 Apr 9:e0143923. doi: 10.1128/aac.01439-23. Online ahead of print.ABSTRACTPhage therapy has (re)emerged as a serious possibility for combating multidrug-resistant bacterial infections, including those caused by vancomycin-resistant Enterococcus faecium strains. These opportunistic pathogens belong to a specific clonal complex 17, against which relatively few phages have been screened. We isolated a collection of 21 virulent phages growing on these vancomycin-resistant isolates. Each of these phages harbored a typical narrow plaquing host range, lysing at most 5 strains and covering together...
Source: Antimicrobial Agents and Chemotherapy - April 9, 2024 Category: Microbiology Authors: Julien Lossouarn Elsa Beurrier Astrid Bouteau Elisabeth Moncaut Maria Sir Silmane He ïdi Portalier Asma Zouari Vincent Cattoir Pascale Serror Marie-Agn ès Petit Source Type: research
Schiff bases and their metal complexes to target and overcome (multidrug) resistance in cancer
Eur J Med Chem. 2024 Mar 29;270:116363. doi: 10.1016/j.ejmech.2024.116363. Online ahead of print.ABSTRACTOvercoming multidrug resistance (MDR) is one of the major challenges in cancer therapy. In this respect, Schiff base-related compounds (bearing a R1R2CNR3 bond) gained high interest during the past decades. Schiff bases are considered privileged ligands for various reasons, including the easiness of their preparation and the possibility to form complexes with almost all transition metal ions. Schiff bases and their metal complexes exhibit many types of biological activities and are used for the treatment and diagnosis o...
Source: European Journal of Medicinal Chemistry - April 9, 2024 Category: Chemistry Authors: Ana Podolski-Reni ć Ana Čipak Gašparović Andreia Valente Óscar López Julia H Bormio Nunes Christian R Kowol Petra Heffeter Nenad R Filipovi ć Source Type: research
Genes, Vol. 15, Pages 473: Factors Influencing Mortality in Children with Central Nervous System Tumors: A Cohort Study on Clinical Characteristics and Genetic Markers
This study investigated the clinical characteristics and single nucleotide variant (SNV) in ABCB1, ABCC1, ABCC2, ABCC4, and ABCG2, and their association with mortality in pediatric patients with central nervous system tumors (CNST). Using TaqMan probes, a real-time polymerase chain reaction genotyped 15 SNPs in 111 samples. Patients were followed up until death or the last follow-up day using the Cox proportional hazards model. An association was found between the rs1045642 (ABCB1) in the recessive model (HR = 2.433, 95% CI 1.098&ndash;5.392, p = 0.029), and the ICE scheme in the codominant model (HR = 9.810, 95% C...
Source: Genes - April 9, 2024 Category: Genetics & Stem Cells Authors: Luz Mar ía Torres-Espíndola Juan Carlos P érez-De Marcos Manuel Castillejos-L ópez Liliana Velasco-Hidalgo Roc ío Cárdenas-Cardós Armando De U ña-Flores Citlaltepetl Salinas-Lara Silvia Caballero-Salazar Rosario Fern ández-Plata Arnoldo Aqu íno- Tags: Article Source Type: research
Serotype diversity and antimicrobial susceptibility profiles of Actinobacillus pleuropneumoniae isolated in Italian pig farms from 2015 to 2022
AbstractActinobacillus pleuropneumoniae (APP) is a bacterium frequently associated with porcine pleuropneumonia. The acute form of the disease is highly contagious and often fatal, resulting in significant economic losses for pig farmers. Serotype diversity and antimicrobial resistance (AMR) of APP strains circulating in north Italian farms from 2015 to 2022 were evaluated retrospectively to investigate APP epidemiology in the area. A total of 572 strains isolated from outbreaks occurring in 337 different swine farms were analysed. The majority of isolates belonged to serotypes 9/11 (39.2%) and 2 (28.1%) and serotype diver...
Source: Veterinary Research - April 9, 2024 Category: Veterinary Research Source Type: research
Ebselen: A Promising Repurposing Drug to Treat Infections Caused by Multidrug-Resistant Microorganisms
Interdiscip Perspect Infect Dis. 2024 Mar 30;2024:9109041. doi: 10.1155/2024/9109041. eCollection 2024.ABSTRACTBacterial multiresistance to drugs is a rapidly growing global phenomenon. New resistance mechanisms have been described in different bacterial pathogens, threatening the effective treatment of even common infectious diseases. The problem worsens in infections associated with biofilms because, in addition to the pathogen's multiresistance, the biofilm provides a barrier that prevents antimicrobial access. Several "non-antibiotic" drugs have antimicrobial activity, even though it is not their primary therapeutic pu...
Source: Interdisciplinary Perspectives on Infectious Diseases - April 8, 2024 Category: Infectious Diseases Authors: Agostinho Alves de Lima E Silva Andr é Rio-Tinto Source Type: research
Variations in Antimicrobial Resistance Genes Present in the Rectal Faeces of Seals in Scottish and Liverpool Bay Coastal Waters
Environ Pollut. 2024 Apr 6:123936. doi: 10.1016/j.envpol.2024.123936. Online ahead of print.ABSTRACTAntibiotic resistance genes originating from human activity are considered important environmental pollutants. Wildlife species can act as sentinels for coastal environmental contamination and in this study we used qPCR array technology to investigate the variety and abundance of antimicrobial resistance genes (ARGs), mobile genetic elements (MGEs) and integrons circulating within seal populations both near to and far from large human populations located around the Scottish and northwest English coast. Rectal swabs were take...
Source: Environmental Pollution - April 8, 2024 Category: Environmental Health Authors: Eleanor Watson Scott Hamilton Nuno Silva Simon Moss Craig Watkins Johanna Baily Thorsten Forster Ailsa J Hall Mark P Dagleish Source Type: research
Ebselen: A Promising Repurposing Drug to Treat Infections Caused by Multidrug-Resistant Microorganisms
Interdiscip Perspect Infect Dis. 2024 Mar 30;2024:9109041. doi: 10.1155/2024/9109041. eCollection 2024.ABSTRACTBacterial multiresistance to drugs is a rapidly growing global phenomenon. New resistance mechanisms have been described in different bacterial pathogens, threatening the effective treatment of even common infectious diseases. The problem worsens in infections associated with biofilms because, in addition to the pathogen's multiresistance, the biofilm provides a barrier that prevents antimicrobial access. Several "non-antibiotic" drugs have antimicrobial activity, even though it is not their primary therapeutic pu...
Source: Interdisciplinary Perspectives on Infectious Diseases - April 8, 2024 Category: Infectious Diseases Authors: Agostinho Alves de Lima E Silva Andr é Rio-Tinto Source Type: research
