Risk Factors Associated with Leishmaniasis in the Most Affected Provinces by Leishmania infantum in Morocco.
This study concerned nine provinces located in the extreme and central north of Morocco (Taounate, Taza, Chefchaouen, Al Hoceima, Larache, Tétouane, Tanger-Assilah, M'diq-Fnideq, and Fahs-Anjra Provinces). In this work, leishmaniasis cases (VL and CL) were subjected to an epidemiological study which was performed using a linear regression model to identify the impact as well as the interaction between all predictor variables on the distribution of leishmaniasis in this region. Results: During the period 1997-2018, a total of 6 128 cases of VL and CL were recorded in the study area. Our results showed that among ...
Source: Interdisciplinary Perspectives on Infectious Diseases - July 18, 2020 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Seroprevalence of Leptospirosis among High-Risk Individuals in Morocco.
Conclusion: Individuals engaged in risk activities are often exposed to leptospiral infection. Therefore, control and prevention policies toward these populations are necessary. PMID: 32565788 [PubMed] (Source: Interdisciplinary Perspectives on Infectious Diseases)
Source: Interdisciplinary Perspectives on Infectious Diseases - June 24, 2020 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Coinfection of Strongyloides stercoralis and Aspergillus sp.
Conclusion. The case highlights the features of concomitant infection of S. stercoralis and Aspergillus in immunocompromised patients and the importance of screening patients for strongyloidiasis before initiation of immunosuppressive therapy. PMID: 32565789 [PubMed] (Source: Interdisciplinary Perspectives on Infectious Diseases)
Source: Interdisciplinary Perspectives on Infectious Diseases - June 24, 2020 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

In Search of Risk Factors for Recurrent Erysipelas and Cellulitis of the Lower Limb: A Cross-Sectional Study of Epidemiological Characteristics of Patients Hospitalized due to Skin and Soft-Tissue Infections.
Conclusions: Patients with lymphedema and obesity should be viewed at high risk of developing recurrence of erysipelas and thus should be considered as candidates for antibiotic prophylaxis and other prevention methods. Minor local trauma directly preceding the skin infection does not by itself confer a higher risk for erysipelas recurrence. More research is needed to assess the association of recurrent skin and soft-tissue infection to preceding minor local trauma, individual components of the metabolic syndrome, and COPD. PMID: 32454817 [PubMed] (Source: Interdisciplinary Perspectives on Infectious Diseases)
Source: Interdisciplinary Perspectives on Infectious Diseases - May 28, 2020 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Predictors of Intestinal Parasitic Infection among Food Handlers Working in Madda Walabu University, Ethiopia: A Cross-Sectional Study.
This study was aimed at determining the predictors of intestinal parasitic infection among food handlers working in Madda Walabu University, Ethiopia. Methods: An institution-based cross-sectional study was conducted from 15 May to 10 June 2017 among 198 symptom-free food handlers. Data on sociodemographic variables were collected through face-to-face interview using a structured questionnaire. Stool samples were collected immediately after the interview using labeled wide-mouthed plastic container and clean wooden applicator. Direct wet-mount method and formal-ether concentration techniques were performed to identify ...
Source: Interdisciplinary Perspectives on Infectious Diseases - May 15, 2020 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Cartography and Epidemiological Study of Leishmaniasis Disease in Sefrou Province (2007-2010), Central North of Morocco.
This study presents the epidemiological profile of the provincial population, aims at analyzing the epidemiological profile, and in particular, spatiotemporal follow-up of all cases of leishmaniasis. It is a retrospective analysis of leishmaniasis cases recorded between 2007 and 2010. The data were analyzed by SPSS software (version 20). Over a four-year period, from 2007 to 2010, there were 62 cases of leishmaniasis, 93.12% of cases of cutaneous leishmaniasis and 6.87% of visceral leishmaniasis. The case number of leishmaniasis in the Province of Sefrou varies between 0.165% and 0.0018%. For each type of leishmaniasis, th...
Source: Interdisciplinary Perspectives on Infectious Diseases - May 9, 2020 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Impact of Urbanization and Socioeconomic Factors on the Distribution of Cutaneous Leishmaniasis in the Center of Morocco.
Conclusion: Our results show that the CL affects the majority of the municipalities with predominance of the urban environment, so the distribution of cases of this pathology is not influenced by the poverty; however, the urbanization and the number of inhabitants have a positive impact on the distribution of this scourge. PMID: 32377183 [PubMed] (Source: Interdisciplinary Perspectives on Infectious Diseases)
Source: Interdisciplinary Perspectives on Infectious Diseases - May 9, 2020 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Extended-Spectrum β-Lactamase (ESBL) Genotypes among Multidrug-Resistant Uropathogenic Escherichia coli Clinical Isolates from a Teaching Hospital of Nepal.
In this study, we aimed to investigate the burden of antimicrobial resistance and occurrence of ESBL genes among clinical isolates of uropathogenic Escherichia coli at a tertiary care teaching hospital of Nepal. During the study period, we processed a total of 1,626 urinary tract specimens, isolated significant bacterial pathogens, and investigated their antimicrobial susceptibilities. Escherichia coli (n = 154), the predominant pathogen associated with UTI, was further investigated for the existence of ESBL enzymes by using conventional phenotypic as well as molecular approaches. Among suspected cases of UTI...
Source: Interdisciplinary Perspectives on Infectious Diseases - May 9, 2020 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Modelling the Transmission Dynamics of Tuberculosis in the Ashanti Region of Ghana.
Authors: Mettle FO, Osei Affi P, Twumasi C Abstract Mathematical models can aid in elucidating the spread of infectious disease dynamics within a given population over time. In an attempt to model tuberculosis (TB) dynamics among high-burden districts in the Ashanti Region of Ghana, the SEIR epidemic model with demography was employed within both deterministic and stochastic settings for comparison purposes. The deterministic model showed success in modelling TB infection in the region to the transmission dynamics of the stochastic SEIR model over time. It predicted tuberculosis dying out in ten of twelve high-burd...
Source: Interdisciplinary Perspectives on Infectious Diseases - April 23, 2020 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Effects of Lysozyme, Proteinase K, and Cephalosporins on Biofilm Formation by Clinical Isolates of Pseudomonas aeruginosa.
Authors: Eladawy M, El-Mowafy M, El-Sokkary MMA, Barwa R Abstract Pseudomonas aeruginosa is an opportunistic pathogen that can form biofilms, which confer resistance to immune clearance and antibacterial treatment. Therefore, effective strategies to prevent biofilm formation are warranted. Here, 103 P. aeruginosa clinical isolates were quantitatively screened for biofilm formation ability via the tissue culture plate method. The effects of lysozyme (hydrolytic enzyme) and proteinase K (protease) on biofilm formation were evaluated at different concentrations. Lysozyme (30 μg/mL), but not proteinase K, sig...
Source: Interdisciplinary Perspectives on Infectious Diseases - February 26, 2020 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Prevalence of Escherichia Coli and Its Antimicrobial Susceptibility Profiles among Patients with UTI at Mulago Hospital, Kampala, Uganda.
Conclusion: Escherichia coli, the predominant uropathogen, showed significant multidrug resistance to antibiotics commonly prescribed for the management of UTIs. These findings should form a basis for preliminary decision making on the appropriate line of treatment for UTIs.Escherichia coli isolates were highly susceptible to cefotaxime/clavulanic acid (100%) and nitrofurantoin (70%) but showed high resistance to cefuroxime (100%), ceftazidime (100%), nalidixic acid (90%), and ciprofloxacin (90%). PMID: 32076437 [PubMed] (Source: Interdisciplinary Perspectives on Infectious Diseases)
Source: Interdisciplinary Perspectives on Infectious Diseases - February 22, 2020 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Markov Chain Modeling of HIV, Tuberculosis, and Hepatitis B Transmission in Ghana.
Authors: Twumasi C, Asiedu L, Nortey ENN Abstract Several mathematical and standard epidemiological models have been proposed in studying infectious disease dynamics. These models help to understand the spread of disease infections. However, most of these models are not able to estimate other relevant disease metrics such as probability of first infection and recovery as well as the expected time to infection and recovery for both susceptible and infected individuals. That is, most of the standard epidemiological models used in estimating transition probabilities (TPs) are not able to generalize the transition esti...
Source: Interdisciplinary Perspectives on Infectious Diseases - December 14, 2019 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Risk Factors for Rubella Transmission in Kuyu District, Ethiopia, 2018: A Case-Control Study.
Authors: Abdulkadir A, Gebrehiwot TT Abstract Background: Rubella is a vaccine-preventable disease associated with a significant morbidity and adverse pregnancy outcomes, mainly if acquired in the first trimester of pregnancy with serious consequences to the fetus. Despite increased episodes of rubella epidemics (127 outbreaks in 2009-2015), rubella national vaccination is not yet introduced in Ethiopia. In January 2018, an increase of fever and rash cases was reported in Kuyu District of Oromia. We investigated the outbreak to confirm rubella, determine risk factors, and guide interventions. Methods: We identi...
Source: Interdisciplinary Perspectives on Infectious Diseases - October 24, 2019 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Predictors of Major Bleeding and Mortality in Dengue Infection: A Retrospective Observational Study in a Tertiary Care Centre in South India.
Authors: John KJ, Gunasekaran K, Prasad JD, Mathew D, Das S, Sultan N, Abraham AM, Iyyadurai R Abstract We conducted a retrospective observational study to describe the clinical profile and outcomes of patients admitted with a diagnosis of dengue fever in a tertiary hospital in South India. A total of 159 patients admitted from April 2014 to October 2018 were included in the study. Vomiting (70.4%), myalgia (60.4%), headache (42.1%), abdominal pain (38.4%), bleeding (38%), and rash (37.1%) were the most common symptoms at presentation. The mean duration of hospital stay was 4.9 days (SD ± 2.4),...
Source: Interdisciplinary Perspectives on Infectious Diseases - October 1, 2019 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Pathology of A(H5N8) (Clade 2.3.4.4) Virus in Experimentally Infected Chickens and Mice.
We report the identification of novel HPAIV A(H5N8) clade 2.3.4.4 virus that was isolated from sick domestic duck at commercial farm during the second wave of spread that began in October and affected poultry (ducks; chiсkens) in several European regions of Russia and Western Siberia in 2016. The strain was highly lethal in experimental infection of chickens and mice with IVPI = 2.34 and MLD50 = 1.3log10⁡ EID50, accordingly. Inoculation of chickens with the HPAIV A/H5N8 demonstrated neuroinvasiveness, multiorgan failure, and death of chickens on the 3rd day post inoculation. Virus replicated in all collected organ sam...
Source: Interdisciplinary Perspectives on Infectious Diseases - July 30, 2019 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Prevalence and Risk Factors of Human Herpes Virus Type 8 (HHV-8), Human Immunodeficiency Virus-1 (HIV-1), and Syphilis among Female Sex Workers in Malindi, Kenya.
Authors: Nzivo MM, Lwembe RM, Odari EO, Kang'ethe JM, Budambula NLM Abstract The prevalence of Human Herpes Virus type 8 (HHV-8), Human Immunodeficiency virus (HIV), and syphilis is high in Sub-Saharan Africa. Studies on HHV-8 in Kenya are few and data on its coinfection with HIV and syphilis scanty. This cross-sectional study among female sex workers (FSWs) in Malindi, Kenya, aimed to determine the prevalence of HHV-8, HIV, and syphilis mono/coinfections and identify associated risk factors. A total of 268 FSWs consented and were administered a structured questionnaire and screened for antibodies against HHV-8, HI...
Source: Interdisciplinary Perspectives on Infectious Diseases - July 20, 2019 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Total Delay in Treatment of Tuberculosis and Associated Factors among New Pulmonary TB Patients in Selected Health Facilities of Gedeo Zone, Southern Ethiopia, 2017/18.
Conclusions: There was higher median total delay in treatment of TB (60 days) and an overall prevalence of 50.9% unacceptable/longer total delay in treatment of TB. Female gender, rural residence, not attending formal education, visiting nonformal health facility as first health care seeking, having poor knowledge of TB, and having antibiotic treatment before TB diagnosis were identified as independent significant associated factors. PMID: 31275370 [PubMed] (Source: Interdisciplinary Perspectives on Infectious Diseases)
Source: Interdisciplinary Perspectives on Infectious Diseases - July 6, 2019 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Awareness and Malaria Prevention Practices in a Rural Community in the Ho Municipality, Ghana.
In this study, we examined the awareness of malaria prevention practices among indigenes of Godokpe, a rural community in the Ho Municipality of Ghana. Methods: This descriptive cross-sectional survey that used a self-developed questionnaire recruited 246 residents of Godokpe who were aged 18 years and above using a systematic sampling technique. The Statistical Package for Social Sciences (SPSS) was used to analyze data into descriptive and analytical statistics. The descriptive statistics comprised frequency, percentage, and means. Also, analytical statistics of cross tabulation was conducted considering a p
Source: Interdisciplinary Perspectives on Infectious Diseases - June 28, 2019 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Assessing the Impact of Isoniazid Preventive Therapy (IPT) on Tuberculosis Incidence and Predictors of Tuberculosis among Adult Patients Enrolled on ART in Nekemte Town, Western Ethiopia: A Retrospective Cohort Study.
Conclusion: Isoniazid preventive therapy use was associated with significant reduction in tuberculosis incidence, even in the absence of Tuberculin Skin Test (TST). Therefore, isoniazid preventive therapy (IPT) coverage should be used more widely, with special emphasis given to patients at higher risk of tuberculosis. The study shows that the absence of TST testing should not be a limitation. PMID: 31186628 [PubMed] (Source: Interdisciplinary Perspectives on Infectious Diseases)
Source: Interdisciplinary Perspectives on Infectious Diseases - June 13, 2019 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Current Perspectives on Treatment of Gram-Positive Infections in India: What Is the Way Forward?
Authors: Kulkarni AP, Nagvekar VC, Veeraraghavan B, Warrier AR, Ts D, Ahdal J, Jain R Abstract The emerging antimicrobial resistance leading to gram-positive infections (GPIs) is one of the major public health threats worldwide. GPIs caused by multidrug resistant bacteria can result in increased morbidity and mortality rates along with escalated treatment cost and hospitalisation stay. In India, GPIs, particularly methicillin-resistant Staphylococcus aureus (MRSA) prevalence among invasive S. aureus isolates, have been reported to increase exponentially from 29% in 2009 to 47% in 2014. Apart from MRSA, rising preva...
Source: Interdisciplinary Perspectives on Infectious Diseases - May 14, 2019 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Utilization of Insecticide Treated Bed Nets (ITNs) among Caregivers of Children under Five Years in the Ho Municipality.
In this study, we examined the utilisation of ITN among caregivers of children under five years in Ho municipality of Ghana. Methods: This descriptive cross-sectional study recruited 283 household representatives through a multistage sampling method. A questionnaire was used to collect the data and was analyzed using STATA version 14. Descriptive and inferential statistics were adopted in presenting the data. Results: Ownership of ITN was higher (80.7%) than its utilisation (41.7%). The age of caregiver was strongly associated with the utilisation of ITN (AOR=2.00, 95% CI=0.00, 0.02, p
Source: Interdisciplinary Perspectives on Infectious Diseases - May 7, 2019 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Channa striata (Ikan Gabus) Extract and the Acceleration of Tuberculosis Treatment: A True Experimental Study.
The objective of the study is to determine the effect of Channa striata extract toward the acceleration of tuberculosis treatment. The study used true experiment, in which the intervention of the study was Channa striata supplementation to respondent. In addition, Chi-square was used to analyze the data with SPSS version 22. The result is the proportion of respondent classified in negative category in intervention group within week 0, week 1, week 2, week 3, and week 4 being 10.7%, 35.9%, 56.3%, 70.9%, and 90.3%, respectively. Besides, the proportion of respondent classified in negative category in control group within wee...
Source: Interdisciplinary Perspectives on Infectious Diseases - April 26, 2019 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Antibiotic Susceptibility Pattern and Biofilm Formation in Clinical Isolates of Enterococcus spp.
Authors: Shridhar S, Dhanashree B Abstract Enterococcus is a commensal in the intestine and is now emerging as a drug-resistant pathogen. It produces different virulence factors. Enterococcus surface protein (esp) is a virulence factor that helps in the adhesion, but its role in biofilm formation is still contradictory. Moreover, in many bacterial species, strong biofilm producer exhibits multidrug resistance. Hence, this study is done to know the antimicrobial susceptibility pattern of Enterococcus spp. and to correlate the drug resistance with biofilm production and esp gene. Enterococcal isolates were collected ...
Source: Interdisciplinary Perspectives on Infectious Diseases - April 5, 2019 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Daclatasvir and Sofosbuvir Therapy Enhance Monocyte Phenotypic Changes in Naive Chronic Hepatitis C Patients: A Prospective Cohort Study.
Conclusion: CHC infection promotes a proinflammatory and profibrotic monocytes profile. SOF/DCV therapy efficiently decreases viral load, reduces fibrosis potentials, attenuates monocyte activation, normalizes monocytes phenotypic abnormalities, and modulates monocyte subsets recruitment and differentiation later in the liver. PMID: 30941170 [PubMed] (Source: Interdisciplinary Perspectives on Infectious Diseases)
Source: Interdisciplinary Perspectives on Infectious Diseases - April 5, 2019 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Vaccine Prophylaxis of Pneumococcal Infections in Children under Conditions of Severe Flood in the Amur River Basin.
Conclusion: Comparative statistical analysis revealed a high degree of effectiveness of regional programs with the methods of immunoprophylaxis of pneumococcal infections. PMID: 30906320 [PubMed] (Source: Interdisciplinary Perspectives on Infectious Diseases)
Source: Interdisciplinary Perspectives on Infectious Diseases - March 26, 2019 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Current Practice and Barriers to an Early Antimicrobial Conversion from Intravenous to Oral among Hospitalized Patients at Jimma University Specialized Hospital: Prospective Observational Study.
Authors: Beyene Berha A, Kassie GM Abstract Objective: The aim of the present study was to explore the current practice and its barriers to an early antimicrobial conversion from intravenous (IV) to oral (PO) therapy among hospitalized patients. Method: Hospital based prospective observational study was conducted to assess the practice of an early antimicrobial IV to PO conversion and its barriers using medical chart and case-specific physicians' interviews, respectively, from February to September, 2014. Patient charts and medication records were reviewed for appropriateness of IV to PO conversion program ever...
Source: Interdisciplinary Perspectives on Infectious Diseases - March 16, 2019 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Vaginal Dysplasia and HIV: An African American and Caribbean American Cohort Study.
Conclusion: In this cohort of Caribbean American and African American women living with HIV diagnosed with VaIN, Caribbean Americans had the highest grade of VaIN at baseline, but more African Americans progressed to more advanced stages of the disease. PMID: 30693024 [PubMed] (Source: Interdisciplinary Perspectives on Infectious Diseases)
Source: Interdisciplinary Perspectives on Infectious Diseases - January 31, 2019 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Brucella Seroprevalence in a High-Risk Population in Greece: A Cross-Sectional Study.
Conclusions: Healthy livestock farmers may present with positive Rose Bengal test but this translates to true seroprevalence in only a small proportion. Livestock farmers have no significant seroprevalence that may obscure diagnosis of acute brucellosis in clinical settings. PMID: 30675154 [PubMed] (Source: Interdisciplinary Perspectives on Infectious Diseases)
Source: Interdisciplinary Perspectives on Infectious Diseases - January 26, 2019 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

An Examination of Bacterial Contamination of Models Used in Anatomy Laboratories.
Conclusion: The necessity of washing hands before and after working on the models and the necessity of occasionally disinfecting the models have emerged. PMID: 30662459 [PubMed] (Source: Interdisciplinary Perspectives on Infectious Diseases)
Source: Interdisciplinary Perspectives on Infectious Diseases - January 24, 2019 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Effects of UVC Irradiation on Growth and Apoptosis of Scedosporium apiospermum and Lomentospora prolificans.
Authors: Muangkaew W, Suwanmanee S, Singkum P, Pumeesat P, Luplertlop N Abstract Scedosporium apiospermum and Lomentospora prolificans are important fungal species isolated from immunocompromised patients. Previous studies have demonstrated that these filamentous fungi exist as saprophytes in the soil and showed the highest minimum inhibitory concentration to several drugs. We aimed to examine how UVC affects the S. apiospermum and L. prolificans by investigating the role of UVC on growth, induction of apoptosis by ethidium bromide (EB)/acridine orange (AO) staining, and transcriptomic study of caspase recruitment ...
Source: Interdisciplinary Perspectives on Infectious Diseases - January 12, 2019 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

The Role of Pneumococcal Virulence Factors in Ocular Infectious Diseases.
Authors: Benton AH, Marquart ME Abstract Streptococcus pneumoniae is a gram-positive, facultatively anaerobic pathogen that can cause severe infections such as pneumonia, meningitis, septicemia, and middle ear infections. It is also one of the top pathogens contributing to bacterial keratitis and conjunctivitis. Though two pneumococcal vaccines exist for the prevention of nonocular diseases, they do little to fully prevent ocular infections. This pathogen has several virulence factors that wreak havoc on the conjunctiva, cornea, and intraocular system. Polysaccharide capsule aids in the evasion of host complement s...
Source: Interdisciplinary Perspectives on Infectious Diseases - December 13, 2018 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Comparative Antiviral Efficacy of Generic Sofosbuvir versus Brand Name Sofosbuvir with Ribavirin for the Treatment of Hepatitis C.
Conclusion: Generic versions of sofosbuvir reported in this study are safe and efficacious to treat hepatitis C. However, bioequivalency studies of all generic DAAs need to be performed before wider use of such drugs for the treatment of hepatitis C. PMID: 30364048 [PubMed] (Source: Interdisciplinary Perspectives on Infectious Diseases)
Source: Interdisciplinary Perspectives on Infectious Diseases - October 27, 2018 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Corrigendum to "Association between Virulence Factors and Extended Spectrum Beta-Lactamase Producing Klebsiella pneumoniae Compared to Nonproducing Isolates".
Corrigendum to "Association between Virulence Factors and Extended Spectrum Beta-Lactamase Producing Klebsiella pneumoniae Compared to Nonproducing Isolates". Interdiscip Perspect Infect Dis. 2018;2018:1023076 Authors: Gharrah MM, Mostafa El-Mahdy A, Barwa RF Abstract [This corrects the article DOI: 10.1155/2017/7279830.]. PMID: 30344604 [PubMed - in process] (Source: Interdisciplinary Perspectives on Infectious Diseases)
Source: Interdisciplinary Perspectives on Infectious Diseases - October 24, 2018 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Monthly or Weekly Supplementation with Cholecalciferol 20,000 IU in People Living with HIV: Results from a Nested Cohort Study.
Conclusion: A higher rate of 25(OH)D level normalization can be achieved via weekly supplementation. For several PLWH, even a weekly dose of cholecalciferol 20,000 IU might not be adequate to maintain 25(OH)D levels>30 ng/mL without an initial "loading" dose. The response to supplementation is poorly predictable at an individual level. PMID: 30245713 [PubMed] (Source: Interdisciplinary Perspectives on Infectious Diseases)
Source: Interdisciplinary Perspectives on Infectious Diseases - September 26, 2018 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Evaluation of Adverse Drug Reaction Profile of Drugs Used as First-Line Antiretroviral Therapy.
Conclusion: Gastrointestinal effects were the most commonly observed group of ADRs, with nausea being the most common ADR, the others being gastritis and diarrhoea. The other ADRs included rash, hepatotoxicity, blood dyscrasias like anaemia, neutropenia, and thrombocytopenia, and fatigue. Few cases of lactic acidosis, peripheral neuropathy, headache, lipoatrophy, and pancreatitis were reported. PMID: 30174689 [PubMed] (Source: Interdisciplinary Perspectives on Infectious Diseases)
Source: Interdisciplinary Perspectives on Infectious Diseases - September 4, 2018 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Assessment of Knowledge, Attitude, and Practice toward Antibiotic Use among Harar City and Its Surrounding Community, Eastern Ethiopia.
Conclusion: In the present study, widespread use of antibiotics was reported, most of this antibiotics being accessed without prescription. Respondent exhibited poor knowledge and attitude toward antibiotics use. There were also malpractices such as failing to take full dose. Therefore, educational interventions on antibiotics use and its association with drug resistance are needed to promote judicious use of antibiotic. Introducing and enforcing antibiotics regulations should be also considered to reduce antibiotics self-prescription. PMID: 30174690 [PubMed] (Source: Interdisciplinary Perspectives on Infectious Diseases)
Source: Interdisciplinary Perspectives on Infectious Diseases - September 4, 2018 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Predictors of Mortality in Scrub Typhus Infection Requiring Intensive Care Admission in Tertiary Healthcare Centre of Nepal.
This study aimed to explore the predictors of mortality from scrub typhus infection in patients requiring intensive care unit (ICU) admission. Materials and Methods: A retrospective study was conducted on 120 patients with serum ELISA IgM positive for scrub typhus (optical density ≥ 0.5) admitted at the medical ICU of Chitwan Medical College Teaching Hospital between April 2016 and September 2017. Data was extracted from patient medical records and electronic database of the hospital. The outcome measurement was mortality (Yes/No) due to the infection. A multivariate binary logistic regression analysis (p
Source: Interdisciplinary Perspectives on Infectious Diseases - July 5, 2018 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Toxoplasma gondii in Blood Donors: A Study in Boyer-Ahmad County, Southwest Iran.
In this study, consumption of undercooked meats, job, and contact with soil were independent risk factors associated with T. gondii infection, which can be considered as potential sources of T. gondii infection. PMID: 29849610 [PubMed] (Source: Interdisciplinary Perspectives on Infectious Diseases)
Source: Interdisciplinary Perspectives on Infectious Diseases - June 2, 2018 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Transmission Dynamics of Bovine Anaplasmosis in a Cattle Herd.
In this study, an age-structured deterministic model for the transmission dynamics of bovine anaplasmosis was developed; the model incorporates symptomatic and asymptomatic cattle classes. Sensitivity analysis was carried out to determine the parameters with the highest impact on the reproduction number. The dominant parameters were the bovine natural and disease-induced death rates, disease progression rate in adult cattle, the mechanical devices transmission probability and contact rates, the pathogen contamination, and decay rates on the mechanical devices. The result of the sensitivity analysis suggests that control st...
Source: Interdisciplinary Perspectives on Infectious Diseases - June 2, 2018 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Influence of Handprint Culture Training on Compliance of Healthcare Workers with Hand Hygiene.
Authors: Fouad H, Halim MMA, Algebaly HF, Elmallakh NA Abstract Objective: We aimed to study the effect of visual observation of bacterial growth from handprints on healthcare workers' (HCWs) compliance with hand hygiene (HH). Settings: Medical and postoperative cardiac surgery units. Design: Prospective cohort study. Subject: The study included 40 HCWs. Intervention: Each HCW was interviewed on 3 separate occasions. The 1st interview was held to obtain a handprint culture before and after a session demonstrating the 7 steps of HH using alcohol-based hand rub, allowing comparison of results before a...
Source: Interdisciplinary Perspectives on Infectious Diseases - May 2, 2018 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Retrospective Assessment of Antibiotics Prescribing at Public Primary Healthcare Facilities in Addis Ababa, Ethiopia.
Conclusion. There was a high rate of antibiotics prescribing in the health centers often empirically which might exacerbate the antimicrobial resistance situation in the country. Large-scale study should be conducted to fully understand the prescribing pattern and identify the associated factors thereby design and implement appropriate interventions. PMID: 29681933 [PubMed] (Source: Interdisciplinary Perspectives on Infectious Diseases)
Source: Interdisciplinary Perspectives on Infectious Diseases - April 25, 2018 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Prevalence and Associated Symptoms of Helicobacter pylori Infection among Schoolchildren in Kassala State, East of Sudan.
Conclusions. The prevalence of H. pylori infection among schoolchildren in Kassala city has been documented. Although the majority of the disease was associated with several gastrointestinal symptoms, the role of infection in the etiology of abdominal symptoms needs further investigations. PMID: 29568312 [PubMed] (Source: Interdisciplinary Perspectives on Infectious Diseases)
Source: Interdisciplinary Perspectives on Infectious Diseases - March 24, 2018 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Early Human Migrations (ca. 13,000 Years Ago) or Postcontact Europeans for the Earliest Spread of Mycobacterium leprae and Mycobacterium lepromatosis to the Americas.
Authors: Mark S Abstract For over a century, it has been widely accepted that leprosy did not exist in the Americas before the arrival of Europeans. This proposition was based on a combination of historical, paleopathological, and representational studies. Further support came from molecular studies in 2005 and 2009 that four Mycobacterium leprae single-nucleotide polymorphisms (SNPs) and then 16 SNP subtypes correlated with general geographic regions, suggesting the M. leprae subtypes in the Americas were consistent with European strains. Shortly thereafter, a number of studies proposed that leprosy first came to ...
Source: Interdisciplinary Perspectives on Infectious Diseases - December 20, 2017 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Families Living with Blood-Borne Viruses: The Case for Extending the Concept of "Serodiscordance".
Families Living with Blood-Borne Viruses: The Case for Extending the Concept of "Serodiscordance". Interdiscip Perspect Infect Dis. 2017;2017:4352783 Authors: Persson A, Newman CE, Hamilton M, Bryant J, Wallace J, Valentine K Abstract The concept of "serodiscordance" (mixed infection status) is primarily associated with epidemiological concerns about HIV transmission risk in couples. We make the case for extending this concept to include families with mixed HIV and viral hepatitis status. Social research on couples with mixed HIV and hepatitis C status has laid an important foundati...
Source: Interdisciplinary Perspectives on Infectious Diseases - December 14, 2017 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Serum Ferritin: A Backstage Weapon in Diagnosis of Dengue Fever.
We examined 30 cases of clinically and serologically confirmed dengue fever and 22 cases of OFI. Ferritin level in dengue cohort was significantly higher than the OFI group (p
Source: Interdisciplinary Perspectives on Infectious Diseases - November 4, 2017 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Local Diversity and Biting Pattern of Anopheles Species in Southern Minahasa.
Authors: Pinontoan OR, Supadmanaba IGP, Manuaba IBA, Sukrama IDM, Manuaba IBP Abstract BACKGROUND: To optimize the preventive measures of malaria, it is important to synchronize the efforts with the behavior of local Anopheles species. However, the data of Anopheles species and their behavior in Indonesia is still lacking. METHOD: Explorative research was conducted from April to September 2016 in Southern Minahasa district. The Anopheles mosquito was baited by using animal and human (indoor or outdoor) from 18.00 to 06.00 hours. Then, the species were identified and Man Biting Rate (MBR) and Man/Animal Biting p...
Source: Interdisciplinary Perspectives on Infectious Diseases - August 29, 2017 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Association between Virulence Factors and Extended Spectrum Beta-Lactamase Producing Klebsiella pneumoniae Compared to Nonproducing Isolates.
In conclusion, this study suggests a correlation between ESBL production and some virulence factors. Therefore, success of treatment depends mainly on increased clinicians awareness and enhanced testing by laboratories to reduce the spread of these isolates. PMID: 28684959 [PubMed - in process] (Source: Interdisciplinary Perspectives on Infectious Diseases)
Source: Interdisciplinary Perspectives on Infectious Diseases - July 9, 2017 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Epidemiological and Clinical Parameters Features of Patients with Clonorchiasis in the Geum River Basin, Republic of Korea.
This study was conducted to evaluate the infection rates of Clonorchis sinensis and laboratory findings in infected people. The 3,167 fecal samples, from nine villages in Okcheon-gun, were examined. PMID: 28529523 [PubMed - in process] (Source: Interdisciplinary Perspectives on Infectious Diseases)
Source: Interdisciplinary Perspectives on Infectious Diseases - May 24, 2017 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Hematological Parameters and Hemozoin-Containing Leukocytes and Their Association with Disease Severity among Malaria Infected Children: A Cross-Sectional Study at Pawe General Hospital, Northwest Ethiopia.
Authors: Birhanu M, Asres Y, Adissu W, Yemane T, Zemene E, Gedefaw L Abstract Hematological parameter changes are the most common complications in malaria. We aimed to determine the hematological parameters and hemozoin-containing leukocytes and their association with disease severity in malaria infected children aged between 1 and 15 years. A facility-based cross-sectional study was conducted at Pawe General Hospital from July 31 to December 30, 2014. Demographic and clinical data were collected using structured questionnaire. Blood specimen was collected from each study participant for hematological investigation...
Source: Interdisciplinary Perspectives on Infectious Diseases - March 19, 2017 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research

Sulfated Glycans and Related Digestive Enzymes in the Zika Virus Infectivity: Potential Mechanisms of Virus-Host Interaction and Perspectives in Drug Discovery.
In this report, the possible mechanisms of action played by glycosaminoglycans (GAGs) displayed at the surface proteoglycans of host cells, and likely in charge of interactions with surface proteins of the ZIKV, are highlighted. As is common for the most viruses, these sulfated glycans serve as receptors for virus attachment onto the host cells and consequential entry during infection. The applications of (1) exogenous sulfated glycans of different origins and chemical structures capable of competing with the virus attachment receptors (supposedly GAGs) and (2) GAG-degrading enzymes able to digest the virus attachment rece...
Source: Interdisciplinary Perspectives on Infectious Diseases - February 20, 2017 Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research