Comparative study of susceptibility to methylmercury cytotoxicity in cell types composing rat peripheral nerves: a higher susceptibility of dorsal root ganglion neurons
In this study, we compared cultured these three cell types derived from the rat for susceptibility to methylmercury cytotoxicity, intracellular accumulation of mercury, expression of L-type amino acid transporter 1 (LAT1), which transports methylmercury into cells, and expression of multidrug resistance-associated protein 2 (MRP2), which transports methylmercury-glutathione conjugates into the extracellular space. Of the cells examined, we found that DRG cells were the most susceptible to methylmercury with markedly higher intracellular accumulation of mercury. The constitutive level of LAT1 was higher and that of MRP2 low...
Source: Journal of Toxicological Sciences - May 1, 2024 Category: Toxicology Authors: Eiko Yoshida Kazuhiro Aoki Yu Sasaki Hinako Izuhara Tsutomu Takahashi Yasuyuki Fujiwara Tomoya Fujie Ke Du Komyo Eto Yo Shinoda Toshiyuki Kaji Source Type: research
Photosensitive AIEgens sensitize bacteria to oxidative damage and modulate the inflammatory responses of macrophages to salvage the photodynamic therapy against MRSA
Biomaterials. 2024 Apr 26;309:122583. doi: 10.1016/j.biomaterials.2024.122583. Online ahead of print.ABSTRACTThe urgent need for antimicrobial agents to combat infections caused by multidrug-resistant bacteria facilitates the exploration of alternative strategies such as photosensitizer (PS)-mediated photoinactivation. However, increasing studies have discovered uncorrelated bactericidal activities among PSs possessing similar photodynamic and pathogen-targeted properties. To optimize the photodynamic therapy (PDT) against infections, we investigated three type-I PSs of D-π-A AIEgens TI, TBI, and TTI. The capacities of re...
Source: Biomaterials - May 1, 2024 Category: Materials Science Authors: Yifan Wu Jiangao Li Liwei Zhu Deliang Wang Jiayi Song Xiyong Yu Ying Li Ben Zhong Tang Source Type: research
Mariculture waters as yet another hotbed for the creation and transfer of new antibiotic-resistant pathogenome
Environ Int. 2024 Apr 26;187:108704. doi: 10.1016/j.envint.2024.108704. Online ahead of print.ABSTRACTWith the rapid growth of aquaculture globally, large amounts of antibiotics have been used to treat aquatic disease, which may accelerate induction and spread of antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) in aquaculture environments. Herein, metagenomic and 16S rRNA analyses were used to analyze the potentials and co-occurrence patterns of pathogenome (culturable and unculturable pathogens), antibiotic resistome (ARGs), and mobilome (mobile genetic elements (MGEs)) from mariculture waters ne...
Source: Environment International - May 1, 2024 Category: Environmental Health Authors: Yiwei Cai Chunliang Chen Tong Sun Guiying Li Wanjun Wang Huijun Zhao Taicheng An Source Type: research
Arginine and tryptophan-rich dendritic antimicrobial peptides that disrupt membranes for bacterial infection in vivo
In conclusion, R2(R2)KW4 has the potential to become an antimicrobial regent or adjuvant, and the minimalist design strategy of dendritic peptides provides innovative and encouraging thoughts in designing AMPs.PMID:38691892 | DOI:10.1016/j.ejmech.2024.116451 (Source: European Journal of Medicinal Chemistry)
Source: European Journal of Medicinal Chemistry - May 1, 2024 Category: Chemistry Authors: Yinyin Yang Zhongwei Yu Zufang Ba Xu Ouyang Beibei Li Ping Yang Jingying Zhang Yu Wang Yao Liu Tingting Yang Yuhuan Zhao Xiaoyan Wu Chao Zhong Hui Liu Yun Zhang Sanhu Gou Jingman Ni Source Type: research
Novel Qnr Families as Conserved and Intrinsic Quinolone Resistance Determinants in < em > Aeromonas < /em > spp
In this study, five environmental strains of Aeromonas spp. exhibiting multidrug resistance (MDR) were selected for whole-genome sequencing to ascertain their taxonomic assignment at the species-level and to delineate their ARG repertoires. Analyses of their genomes revealed the presence of one protein almost identical to AhQnr (A. hydrophila Qnr protein) and four novel proteins similar to AhQnr. To scrutinize the classification and taxonomic distribution of these proteins, all Aeromonas genomes deposited in the NCBI RefSeq genome database (1,222 genomes) were investigated. This revealed that these Aeromonas Qnr (AQnr) pro...
Source: Journal of Microbiology and Biotechnology - May 1, 2024 Category: Biotechnology Authors: Sang-Gyu Kim Bo-Eun Kim Jung Hun Lee Dae-Wi Kim Source Type: research
Comparative study of susceptibility to methylmercury cytotoxicity in cell types composing rat peripheral nerves: a higher susceptibility of dorsal root ganglion neurons
In this study, we compared cultured these three cell types derived from the rat for susceptibility to methylmercury cytotoxicity, intracellular accumulation of mercury, expression of L-type amino acid transporter 1 (LAT1), which transports methylmercury into cells, and expression of multidrug resistance-associated protein 2 (MRP2), which transports methylmercury-glutathione conjugates into the extracellular space. Of the cells examined, we found that DRG cells were the most susceptible to methylmercury with markedly higher intracellular accumulation of mercury. The constitutive level of LAT1 was higher and that of MRP2 low...
Source: Journal of Toxicological Sciences - May 1, 2024 Category: Toxicology Authors: Eiko Yoshida Kazuhiro Aoki Yu Sasaki Hinako Izuhara Tsutomu Takahashi Yasuyuki Fujiwara Tomoya Fujie Ke Du Komyo Eto Yo Shinoda Toshiyuki Kaji Source Type: research
Photosensitive AIEgens sensitize bacteria to oxidative damage and modulate the inflammatory responses of macrophages to salvage the photodynamic therapy against MRSA
Biomaterials. 2024 Apr 26;309:122583. doi: 10.1016/j.biomaterials.2024.122583. Online ahead of print.ABSTRACTThe urgent need for antimicrobial agents to combat infections caused by multidrug-resistant bacteria facilitates the exploration of alternative strategies such as photosensitizer (PS)-mediated photoinactivation. However, increasing studies have discovered uncorrelated bactericidal activities among PSs possessing similar photodynamic and pathogen-targeted properties. To optimize the photodynamic therapy (PDT) against infections, we investigated three type-I PSs of D-π-A AIEgens TI, TBI, and TTI. The capacities of re...
Source: Biomaterials - May 1, 2024 Category: Materials Science Authors: Yifan Wu Jiangao Li Liwei Zhu Deliang Wang Jiayi Song Xiyong Yu Ying Li Ben Zhong Tang Source Type: research
Arginine and tryptophan-rich dendritic antimicrobial peptides that disrupt membranes for bacterial infection in vivo
In conclusion, R2(R2)KW4 has the potential to become an antimicrobial regent or adjuvant, and the minimalist design strategy of dendritic peptides provides innovative and encouraging thoughts in designing AMPs.PMID:38691892 | DOI:10.1016/j.ejmech.2024.116451 (Source: European Journal of Medicinal Chemistry)
Source: European Journal of Medicinal Chemistry - May 1, 2024 Category: Chemistry Authors: Yinyin Yang Zhongwei Yu Zufang Ba Xu Ouyang Beibei Li Ping Yang Jingying Zhang Yu Wang Yao Liu Tingting Yang Yuhuan Zhao Xiaoyan Wu Chao Zhong Hui Liu Yun Zhang Sanhu Gou Jingman Ni Source Type: research
Novel Qnr Families as Conserved and Intrinsic Quinolone Resistance Determinants in < em > Aeromonas < /em > spp
In this study, five environmental strains of Aeromonas spp. exhibiting multidrug resistance (MDR) were selected for whole-genome sequencing to ascertain their taxonomic assignment at the species-level and to delineate their ARG repertoires. Analyses of their genomes revealed the presence of one protein almost identical to AhQnr (A. hydrophila Qnr protein) and four novel proteins similar to AhQnr. To scrutinize the classification and taxonomic distribution of these proteins, all Aeromonas genomes deposited in the NCBI RefSeq genome database (1,222 genomes) were investigated. This revealed that these Aeromonas Qnr (AQnr) pro...
Source: Journal of Microbiology and Biotechnology - May 1, 2024 Category: Biotechnology Authors: Sang-Gyu Kim Bo-Eun Kim Jung Hun Lee Dae-Wi Kim Source Type: research
Comparative study of susceptibility to methylmercury cytotoxicity in cell types composing rat peripheral nerves: a higher susceptibility of dorsal root ganglion neurons
In this study, we compared cultured these three cell types derived from the rat for susceptibility to methylmercury cytotoxicity, intracellular accumulation of mercury, expression of L-type amino acid transporter 1 (LAT1), which transports methylmercury into cells, and expression of multidrug resistance-associated protein 2 (MRP2), which transports methylmercury-glutathione conjugates into the extracellular space. Of the cells examined, we found that DRG cells were the most susceptible to methylmercury with markedly higher intracellular accumulation of mercury. The constitutive level of LAT1 was higher and that of MRP2 low...
Source: Journal of Toxicological Sciences - May 1, 2024 Category: Toxicology Authors: Eiko Yoshida Kazuhiro Aoki Yu Sasaki Hinako Izuhara Tsutomu Takahashi Yasuyuki Fujiwara Tomoya Fujie Ke Du Komyo Eto Yo Shinoda Toshiyuki Kaji Source Type: research
Novel Qnr Families as Conserved and Intrinsic Quinolone Resistance Determinants in < em > Aeromonas < /em > spp
In this study, five environmental strains of Aeromonas spp. exhibiting multidrug resistance (MDR) were selected for whole-genome sequencing to ascertain their taxonomic assignment at the species-level and to delineate their ARG repertoires. Analyses of their genomes revealed the presence of one protein almost identical to AhQnr (A. hydrophila Qnr protein) and four novel proteins similar to AhQnr. To scrutinize the classification and taxonomic distribution of these proteins, all Aeromonas genomes deposited in the NCBI RefSeq genome database (1,222 genomes) were investigated. This revealed that these Aeromonas Qnr (AQnr) pro...
Source: Journal of Microbiology and Biotechnology - May 1, 2024 Category: Biotechnology Authors: Sang-Gyu Kim Bo-Eun Kim Jung Hun Lee Dae-Wi Kim Source Type: research
A review on potential heterocycles for the treatment of glioblastoma targeting receptor tyrosine kinases
Oncol Res. 2024 Apr 23;32(5):849-875. doi: 10.32604/or.2024.047042. eCollection 2024.ABSTRACTGlioblastoma, the most aggressive form of brain tumor, poses significant challenges in terms of treatment success and patient survival. Current treatment modalities for glioblastoma include radiation therapy, surgical intervention, and chemotherapy. Unfortunately, the median survival rate remains dishearteningly low at 12-15 months. One of the major obstacles in treating glioblastoma is the recurrence of tumors, making chemotherapy the primary approach for secondary glioma patients. However, the efficacy of drugs is hampered by the...
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Nilam Bhusare Maushmi Kumar Source Type: research
< em > In vitro < /em > Antibacterial Activity of Ethanolic Tanao Si Kan Dang RD1 ( < em > Cannabis sativa < /em > L.) Extracts Against Human Antibiotic-Resistant Bacteria
Conclusion:</b> This study presents a novel finding regarding the antibacterial activity of ethanolic extracts from the leaves and stems of Tanao Si Kan Dang RD1 against antibiotic-resistant bacteria. The potential application of these cannabis plant extracts in the development of antibiotics capable of combating antibiotic-resistant pathogenic bacteria represents a promising strategy to address a significant global health concern.PMID:38686733 | DOI:10.3923/pjbs.2024.119.124 (Source: Pakistan Journal of Biological Sciences: PJBS)
Source: Pakistan Journal of Biological Sciences: PJBS - April 30, 2024 Category: Biomedical Science Authors: Nipaporn Armassa Duanpen Wongsorn Benya Saenmahayak Somsak Rayan Surachai Rattanasuk Source Type: research
A review on potential heterocycles for the treatment of glioblastoma targeting receptor tyrosine kinases
Oncol Res. 2024 Apr 23;32(5):849-875. doi: 10.32604/or.2024.047042. eCollection 2024.ABSTRACTGlioblastoma, the most aggressive form of brain tumor, poses significant challenges in terms of treatment success and patient survival. Current treatment modalities for glioblastoma include radiation therapy, surgical intervention, and chemotherapy. Unfortunately, the median survival rate remains dishearteningly low at 12-15 months. One of the major obstacles in treating glioblastoma is the recurrence of tumors, making chemotherapy the primary approach for secondary glioma patients. However, the efficacy of drugs is hampered by the...
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Nilam Bhusare Maushmi Kumar Source Type: research
< em > In vitro < /em > Antibacterial Activity of Ethanolic Tanao Si Kan Dang RD1 ( < em > Cannabis sativa < /em > L.) Extracts Against Human Antibiotic-Resistant Bacteria
Conclusion:</b> This study presents a novel finding regarding the antibacterial activity of ethanolic extracts from the leaves and stems of Tanao Si Kan Dang RD1 against antibiotic-resistant bacteria. The potential application of these cannabis plant extracts in the development of antibiotics capable of combating antibiotic-resistant pathogenic bacteria represents a promising strategy to address a significant global health concern.PMID:38686733 | DOI:10.3923/pjbs.2024.119.124 (Source: Pakistan Journal of Biological Sciences: PJBS)
Source: Pakistan Journal of Biological Sciences: PJBS - April 30, 2024 Category: Biomedical Science Authors: Nipaporn Armassa Duanpen Wongsorn Benya Saenmahayak Somsak Rayan Surachai Rattanasuk Source Type: research
