Multidrug Resistance Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Epidemiology, resistance genomics and susceptibility of Acinetobacter species: results from the 2020 Spanish nationwide surveillance study
ConclusionsThe emergence of OXA-23-producing ST1 and ST2, the predominant MDR lineages, shows a pivotal shift in carbapenem-resistant A. baumannii (CRAB) epidemiology in Spain. Coupled with increased colistin resistance, these changes underscore notable alterations in regional antimicrobial resistance dynamics.PMID:38606569 | DOI:10.2807/1560-7917.ES.2024.29.15.2300352 (Source: Euro Surveill)
Source: Euro Surveill - April 12, 2024 Category: Infectious Diseases Authors: Cristina Lasarte-Monterrubio Paula Guijarro-S ánchez Isaac Alonso-Garcia Michelle Outeda Romina Maceiras Lucia Gonz ález-Pinto Marta Mart ínez-Guitián Carlos Fern ández-Lozano Juan Carlos V ázquez-Ucha German Bou Jorge Arca-Su árez Alejandro Beceir Source Type: research

Peptide Extract from Red Kidney Beans, Phaseolus vulgaris (Fabaceae), Shows Promising Antimicrobial, Antibiofilm, and Quorum Sensing Inhibitory Effects
In this study, peptides were extracted from the seeds of Phaseolus vulgaris (Fabaceae), and the antimicrobial activities of the extract were evaluated using microbroth dilution against five different microorganisms. The extract showed antimicrobial activity against all tested organisms with minimum inhibitory concentrations (MIC) of 2.5 mg/mL, except for Candida albicans and Pseudomonas aeruginosa, which had MICs of 1.25 mg/mL. The extract was also bacteriostatic for all tested organisms. The crude peptide extract from Phaseolus vulgaris was further studied for its antibiofilm activity against Pseudomonas aeruginosa, a com...
Source: Cell Research - April 12, 2024 Category: Cytology Authors: Jennifer Tetteh De-Youngster Wereko Brobbey Kofi Junior Osei Azumah Ayamah Michael Konney Laryea Godfred Darko Lawrence Sheringham Borquaye Source Type: research

Epidemiology, resistance genomics and susceptibility of Acinetobacter species: results from the 2020 Spanish nationwide surveillance study
ConclusionsThe emergence of OXA-23-producing ST1 and ST2, the predominant MDR lineages, shows a pivotal shift in carbapenem-resistant A. baumannii (CRAB) epidemiology in Spain. Coupled with increased colistin resistance, these changes underscore notable alterations in regional antimicrobial resistance dynamics.PMID:38606569 | PMC:PMC11010588 | DOI:10.2807/1560-7917.ES.2024.29.15.2300352 (Source: Euro Surveill)
Source: Euro Surveill - April 12, 2024 Category: Infectious Diseases Authors: Cristina Lasarte-Monterrubio Paula Guijarro-S ánchez Isaac Alonso-Garcia Michelle Outeda Romina Maceiras Lucia Gonz ález-Pinto Marta Mart ínez-Guitián Carlos Fern ández-Lozano Juan Carlos V ázquez-Ucha German Bou Jorge Arca-Su árez Alejandro Beceir Source Type: research

A sophisticated virulence repertoire and colistin resistance of Citrobacter freundii ST150 from a patient with sepsis admitted to ICU in a tertiary care hospital in Uganda, East Africa: Insight from genomic and molecular docking analyses
Infect Genet Evol. 2024 Apr 9:105591. doi: 10.1016/j.meegid.2024.105591. Online ahead of print.ABSTRACTSepsis and multidrug resistance comprise a complex of factors attributable to mortality among intensive care unit (ICU) patients globally. Pathogens implicated in sepsis are diverse, and their virulence and drug resistance remain elusive. From a tertiary care hospital ICU in Uganda, we isolated a Citrobacter freundii strain RSM030 from a patient with sepsis and phenotypically tested it against a panel of 16 antibiotics including imipenem levofloxacin, cotrimoxazole and colistin, among others. We sequenced the organism's g...
Source: Infection, Genetics and Evolution - April 11, 2024 Category: Genetics & Stem Cells Authors: Reuben S Maghembe Maximilian A K Magulye Emmanuel Eilu Simon Sekyanzi Abdalah Makaranga Savannah Mwesigwa Eric Katagirya Source Type: research

Nutritional Sources and Anticancer Potential of Phenethyl Isothiocyanate: Molecular Mechanisms and Therapeutic Insights
Phenethyl Isothiocyanate (PEITC) exhibits its anticancer potential by modulating key signaling pathways, enforcing cell cycle arrest, promoting apoptosis, and enhancing drug efficacy by overcoming multidrug resistance and influencing drug metabolism enzymes. AbstractPhenethyl isothiocyanate (PEITC), a compound derived from cruciferous vegetables, has garnered attention for its anticancer properties. This review synthesizes existing research on PEITC, focusing on its mechanisms of action in combatting cancer. PEITC has been found to be effective against various cancer types, such as breast, prostate, lung, colon, and pancre...
Source: Molecular Nutrition and Food Research - April 11, 2024 Category: Food Science Authors: Shahira M. Ezzat, Rana M. Merghany, Passent M. Abdel Baki, Nariman Ali Abdelrahim, Sohaila M. Osman, Mohamed A. Salem, Sheila I. Pe ña‐Corona, Hernán Cortés, Lashyn Kiyekbayeva, Gerardo Leyva‐Gómez, Javad Sharifi‐Rad, Daniela Calina Tags: Review Source Type: research

Epidemiology, resistance genomics and susceptibility of Acinetobacter species: results from the 2020 Spanish nationwide surveillance study
ConclusionsThe emergence of OXA-23-producing ST1 and ST2, the predominant MDR lineages, shows a pivotal shift in carbapenem-resistantA. baumannii (CRAB) epidemiology in Spain. Coupled with increased colistin resistance, these changes underscore notable alterations in regional antimicrobial resistance dynamics. (Source: Eurosurveillance)
Source: Eurosurveillance - April 11, 2024 Category: Infectious Diseases Authors: Cristina Lasarte-Monterrubio, Paula Guijarro-S ánchez, Isaac Alonso-Garcia, Michelle Outeda, Romina Maceiras, Lucia González-Pinto, Marta Martínez-Guitián, Carlos Fernández-Lozano, Juan Carlos Vázquez-Ucha, German Bou, Jorge Arca-Suárez and Alejand Source Type: research

Crucifer Lesion-Associated Xanthomonas Strains Show Multi-Resistance to Heavy Metals and Antibiotics
In this study, multi-resistance to heavy metals and antibiotics were evaluated in local Xanthomonas campestris pv. campestris (Xcc) and co-isolated Xanthomonas melonis (Xmel) strains from infected crucifer plants in Trinidad. Resistance to cobalt, cadmium, zinc, copper, and arsenic (V) was observed in both Xanthomonas species up to 25 mM. Heavy metal resistance (HMR) genes were found on a small plasmid-derived locus with ~ 90% similarity to a Stenotrophomonas spp. chromosomal locus and a X. perforans pLH3.1 plasmid. The co-occurrence of mobile elements in these regions implies their organization on a composite transposon-l...
Source: Current Microbiology - April 10, 2024 Category: Microbiology Authors: Stephen D B Jr Ramnarine Jayaraj Jayaraman Adesh Ramsubhag Source Type: research

Genome-Wide Investigation Reveals Potential Therapeutic Targets in Shigella spp
In this study, 2,146 ARGs were predicted in 45 genomes (average 47.69 ARGs/genome), of which only 91 ARGs were found to be shared across the genomes. Majority of these ARGs conferred their resistance through antibiotic efflux pump (51.0%) followed by antibiotic target alteration (23%) and antibiotic target replacement (18%). We identified 13 hub proteins, of which four proteins (e.g., tolC, acrR, mdtA, and gyrA) were detected as potential hub proteins to be associated with antibiotic efflux pump and target alteration mechanisms. These hub proteins were significantly (p < 0.05) enriched in biological process, molecular f...
Source: Biomed Res - April 10, 2024 Category: Research Authors: Md Arju Hossain Md Al Amin Md Arif Khan Md Rashedur Rahman Refat Md Sohel Md Habibur Rahman Ariful Islam M Nazmul Hoque Source Type: research