Late ‐Night Eating‐Induced Physiological Dysregulation and Circadian Misalignment are Accompanied by Microbial Dysbiosis
ConclusionLate ‐night eating caused physiological dysregulation and misalignment of circadian rhythm, together with microbial dysbiosis.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 19, 2019 Category: Food Science Authors: Yinhua Ni, Lianxin Wu, Jinlu Jiang, Tianqi Yang, Ze Wang, Lingyan Ma, Liujie Zheng, Xin Yang, Zeming Wu, Zhengwei Fu Tags: Research Article Source Type: research

Naringenin Exerts Cardiovascular Protective Effect in a Palmitate ‐Induced Human Umbilical Vein Endothelial Cell Injury Model via Autophagy Flux Improvement
ConclusionThese findings provide a possible mechanism by which naringenin prevents endothelial dysfunction and cardiovascular diseases.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 17, 2019 Category: Food Science Authors: Qiang Zhao, Hongyan Yang, Fen Liu, Junyi Luo, Qian Zhao, Xiaomei Li, Yining Yang Tags: Research Article Source Type: research

Avocatin B Protects Against Lipotoxicity and Improves Insulin Sensitivity in Diet ‐Induced Obesity
Conclusion: Therapeutic agents that are safe and effectively inhibit FAO and improve DIO ‐associated pathologies are currently not available. AvoB's mechanism of action and favorable safety profile highlight its nutritional and clinical importance.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 14, 2019 Category: Food Science Authors: Nawaz Ahmed, Matthew Tcheng, Alessia Roma, Michael Buraczynski, Preethi Jayanth, Kevin Rea, Tariq A. Akhtar, Paul A. Spagnuolo Tags: Research Article Source Type: research

The Janus Face of Cereals: Wheat ‐Derived Prebiotics Counteract the Detrimental Effect of Gluten on Metabolic Homeostasis in Mice Fed a High Fat/High Sucrose Diet
ConclusionWhile gluten may affect metabolic homeostasis, these effects are lessened when gluten is consumed along with cereal ‐derived fibers. If confirmed in humans, we bring new arguments to eat fiber‐rich cereals to promote a healthy diet.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 13, 2019 Category: Food Science Authors: Marta Olivares, Julie Rodriguez, Sarah A. P ötgens, Audrey M. Neyrinck, Patrice D. Cani, Laure B. Bindels, Nathalie M. Delzenne Tags: Research Article Source Type: research

Mastiha (Pistacia Lentiscus) Improves Gut Microbiota Diversity, Hepatic Steatosis and Disease Activity in a Biopsy ‐Confirmed Mouse Model of Advanced Non‐Alcoholic Steatohepatitis and Fibrosis
ConclusionThis is the first study demonstrating an improvement in disease activity in mice with advanced NASH with fibrosis by a diet containing Mastiha.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 10, 2019 Category: Food Science Authors: Aimo Kannt, Efstathia Papada, Claire Kammermeier, Giuseppe D'Auria, Nuria Jim énez‐Hernández, Martin Stephan, Uwe Schwahn, Andreas Nygaard Madsen, Mette Viberg Ostergaard, George Dedoussis, on behalf of the MAST4HEALTH consortium Tags: Food & Function Source Type: research

Dietary Protein Sources Differentially Affect the Growth of Akkermansia muciniphila and Maintenance of the Gut Mucus Barrier in Mice
ConclusionThese findings suggest possible mutually beneficial interactions between the growth and function ofA. muciniphila and host mucus barrier in response to intake of a chicken protein ‐based diet contrasting the intake of a soy protein‐based diet.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 6, 2019 Category: Food Science Authors: Fan Zhao, Guanghong Zhou, Xinyue Liu, Shangxin Song, Xinglian Xu, Guido Hooiveld, Michael M üller, Li Liu, Karsten Kristiansen, Chunbao Li Tags: Research Article Source Type: research

Soy and Isoflavone Consumption and Multiple Health Outcomes: Umbrella Review of Systematic Reviews and Meta ‐Analyses of Observational Studies and Randomised Trials in Humans
ConclusionGenerally, soy and isoflavone consumption was more beneficial than harmful in this review. Our results support that promote soy intake as part of a healthy diet. Randomised controlled trials are necessary to confirm this finding.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 4, 2019 Category: Food Science Authors: Ni Li, Xiaoting Wu, Wen Zhuang, Lin Xia, Yi Chen, Rui Zhao, Mengshi Yi, Qianyi Wan, Liang Du, Yong Zhou Tags: Review Source Type: research

The Alternaria Mycotoxin Alternariol Triggers the Immune Response of IL ‐1β‐stimulated, Differentiated Caco‐2 Cells
ConclusionThe obtained data indicate that AOH represses immune responses in an inflamed environment, possibly leading to higher susceptibility to diseases. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 4, 2019 Category: Food Science Authors: Cornelia Schmutz, Ebru Cenk, Doris Marko Tags: Research Article Source Type: research

Coenzyme Q10 Upregulates Platelet cAMP/PKA Pathway and Attenuates Integrin αIIbβ3 Signaling and Thrombus Growth
ConclusionThrough upregulating the platelet cAMP/PKA pathway, and attenuating αIIbβ3 signaling and thrombus growth, CoQ10 supplementation may play an important protective role in patients with risks of cardiovascular diseases. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 3, 2019 Category: Food Science Authors: Fuli Ya, Xiaohong Ruby Xu, Yilin Shi, Reid C. Gallant, Fenglin Song, Xiao Zuo, Yimin Zhao, Zezhong Tian, Cheng Zhang, Xiping Xu, Wenhua Ling, Heyu Ni, Yan Yang Tags: Research Article Source Type: research

The Contribution of Lipids to the Interindividual Response of Vitamin K Biomarkers to Vitamin K Supplementation
Contributions of lipids to interindividual variability in biomarkers of vitamin K were examined in a secondary analysis of data from a three ‐year randomized phylloquinone (the major dietary and circulating form of vitamin K) supplementation trial. Plasma triglycerides contributed to the interindividual response of circulating phylloquinone, but interindividual changes in biomarkers of vitamin K carboxylation were not influenced by lip ids. ScopeA better understanding of factors contributing to interindividual variability in biomarkers of vitamin K can enhance the understanding of the equivocal role of vitamin K in cardi...
Source: Molecular Nutrition and Food Research - October 3, 2019 Category: Food Science Authors: Jennifer M. Kelly, Jose M. Ordovas, Gregory Matuszek, Caren E. Smith, Gordon S. Huggins, Hassan S. Dashti, Reiko Ichikawa, Sarah L. Booth Tags: Research Article Source Type: research

Maresin 1 Regulates Hepatic FGF21 in Diet ‐Induced Obese Mice and in Cultured Hepatocytes
ConclusionsThe ability of MaR1 to modulate FGF21 could contribute to its beneficial metabolic effects.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 2, 2019 Category: Food Science Authors: L. Mart ínez‐Fernández, P. González‐Muniesa, N. Sainz, L. M. Laiglesia, X. Escoté, J. A. Martínez, M. J. Moreno‐Aliaga Tags: Research Article Source Type: research

Adzuki Bean Water Extract Attenuates Obesity by Modulating M2/M1 Macrophage Polarization and Gut Microbiota Composition
ConclusionThe results demonstrate that AWE supplementation ameliorates HFD ‐induced obesity and gut microbiota composition and suggest that AWE may have potential to be developed into a functional food to improve metabolic disorders.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 1, 2019 Category: Food Science Authors: Pei ‐Sheng Lee, Chia‐Yi Teng, Kun‐Feng Hsieh, Yi‐Shiou Chiou, Jia‐Ching Wu, Ting‐Jang Lu, Min‐Hsiung Pan Tags: Research Article Source Type: research

Front Cover: Increased Dairy Product Intake Alters Serum Metabolite Profiles in Subjects at Risk of Developing Type 2 Diabetes
Mol. Nutr. Food Res. 2019,63,https://doi.org/10.1002/mnfr.2019001261900126DOI:10.1002/mnfr.201900126In article numberhttps://doi.org/10.1002/mnfr.2019001261900126, Iwona Rudkowska and co ‐workers find that individuals at risk of diabetes who consume four to five portions of dairy products per day show modified levels of specific metabolites (pentadecanoic acid, tyrosine, 1,5‐anhydrosorbitol, beta‐sitosterol, sorbitol, and sucrose) compared to lower dairy product intake. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 1, 2019 Category: Food Science Authors: Sarah O'Connor, Karine Greffard, Mickael Leclercq, Pierre Julien, Stanley John Weisnagel, Claudia Gagnon, Arnaud Droit, Jean ‐François Bilodeau, Iwona Rudkowska Tags: Front Cover Source Type: research

Editorial Board: Mol. Nutr. Food Res. 19'19
Molecular Nutrition&Food Research, Volume 63, Issue 19, October 2019. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 1, 2019 Category: Food Science Tags: Editorial Board Source Type: research

GutSelf: Interindividual Variability in the Processing of Dietary Compounds by the Human Gastrointestinal Tract
Despite numerous examples of interindividual variability in the processing of food by the human gastrointestinal tract, the knowledge on this topic, as illustrated for polymorphisms in mineral absorption, remains fragmented. The GutSelf review sets the base for motivating future research specifically addressing the issue of the interindividual variability in the response of the human organism to the ingestion of foods. AbstractNutritional research is currently entering the field of personalized nutrition, to a large extent driven by major technological breakthroughs in analytical sciences and biocomputing. An efficient lau...
Source: Molecular Nutrition and Food Research - October 1, 2019 Category: Food Science Authors: Barbara Walther, Aaron M. Lett, Alessandra Bordoni, Lidia Tom ás‐Cobos, Juan Antonio Nieto, Didier Dupont, Francesca Danesi, Danit R. Shahar, Ana Echaniz, Roberta Re, Aida Sainz Fernandez, Amélie Deglaire, Doreen Gille, Alexandra Schmid, Tags: Review Source Type: research

Green Tea Extract Treatment in Obese Mice with Nonalcoholic Steatohepatitis Restores the Hepatic Metabolome in Association with Limiting Endotoxemia ‐TLR4‐NFκB‐Mediated Inflammation
ScopeCatechin ‐rich green tea extract (GTE) alleviates nonalcoholic steatohepatitis (NASH) by lowering endotoxin‐TLR4‐NFκB inflammation. We aimed to define altered MS‐metabolomic responses in a high‐fat (HF)‐induced NASH model that are restored by GTE utilizing livers from an earlier study in which G TE decreased endotoxin‐TLR4‐NFκB liver injury.Methods and ResultsMice were fed a low ‐fat (LF) or HF diet for 12‐wk and then randomized to LF or HF diets containing 0% or 2% GTE for an additional 8‐wk. Global MS‐based metabolomics and targeted metabolite profiling of catechins/catechin metab...
Source: Molecular Nutrition and Food Research - October 1, 2019 Category: Food Science Authors: Geoffrey Y. Sasaki, Jinhui Li, Morgan J. Cichon, Ken M. Riedl, Rachel E. Kopec, Richard S. Bruno Tags: Research Article Source Type: research

Integrated Analys of High ‐Fat Challenge‐Induced Changes in Blood Cell Whole‐Genome Gene Expression
ConclusionA general gene expression response to a high ‐fat challenge is identified. Compared to separate analyses, integrated analysis provides added value for the discovery of a consistent gene expression response. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - September 30, 2019 Category: Food Science Authors: Juri C. Matualatupauw, Colm O'Grada, Maria F. Hughes, Helen M. Roche, Lydia A. Afman, Jildau Bouwman Tags: Research Article Source Type: research

ω‐3 PUFAs Alleviate High‐Fat Diet–Induced Circadian Intestinal Microbes Dysbiosis
ConclusionThe data show that FO and AO alleviate circadian gut microbiota dysregulation in mice caused by HFD, and support the further investigation of ω‐3 PUFAs as a dietary intervention strategy for the prevention of hyperlipidemia. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - September 30, 2019 Category: Food Science Authors: Lifeng Gui, Si Chen, Hualin Wang, Mengcheng Ruan, Yang Liu, Na Li, Hongyu Zhang, Zhiguo Liu Tags: Research Article Source Type: research

Abundance of Probiotics and Butyrate ‐Production Microbiome Manages Constipation Via Short‐Chain Fatty Acids Production and Hormones Secretion
ConclusionGut microbiota, characterized with enriched butyrate ‐producing and depressedDesulfovibrionaceae bacteria, attenuated constipation symptom through promoting intestinal hormones secretion and maintaining gut barrier integrity.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - September 25, 2019 Category: Food Science Authors: Min Zhuang, Wenting Shang, Qiuchen Ma, Padraig Strappe, Zhongkai Zhou Tags: Research Article Source Type: research

Lactobacillus and Bifidobacterium Improves Physiological Function and Cognitive Ability in Aged Mice by the Regulation of Gut Microbiota
ConclusionL. casei LC122 andB. longum BL986 might be used as novel and promising anti ‐aging agents in human. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - September 25, 2019 Category: Food Science Authors: Yinhua Ni, Xin Yang, Liujie Zheng, Zhe Wang, Lianxin Wu, Jinlu Jiang, Tianqi Yang, Lingyan Ma, Zhengwei Fu Tags: Research Article Source Type: research

Capsaicin Improves Glucose Tolerance and Insulin Sensitivity Through Modulation of the Gut Microbiota ‐Bile Acid‐FXR Axis in Type 2 Diabetic db/db Mice
ConclusionsCAP ‐induced improvements in BA and glucose metabolism are partially mediated by the gut microbiota‐BA‐enterohepatic FXR axis indb/db mice.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - September 20, 2019 Category: Food Science Authors: Suocheng Hui, Yang Liu, Mengting Chen, Xiaolan Wang, Hedong Lang, Min Zhou, Long Yi, Mantian Mi Tags: Research Article Source Type: research

Back Cover: Physiological Concentrations of Blueberry ‐Derived Phenolic Acids Reduce Monocyte Adhesion to Human Endothelial Cells
Mol. Nutr. Food Res. 2019,63,https://doi.org/10.1002/mnfr.2019004781900478DOI:10.1002/mnfr.201900478In article numberhttps://doi.org/10.1002/mnfr.2019004781900478, Margreet C. M. Vissers and co ‐workers investigate the activity of bioavailable, blueberry‐derived phenolic acid metabolites on the adhesion of monocytes to vascular endothelial cells. This work shows that a physiologically relevant mixture of phenolic acid metabolites, based on those found in plasma following blueberry juic e intake, can reduce monocyte adhesion to endothelial cells. This suggests a mechanism by which blueberry polyphenol metabolites may be...
Source: Molecular Nutrition and Food Research - September 19, 2019 Category: Food Science Authors: Jeffry S. Tang, Stephanie M. Bozonet, Judith L. McKenzie, Robert F. Anderson, Laurence D. Melton, Margreet C. M. Vissers Tags: Back Cover Source Type: research

Front Cover: The Preventative Effects of Procyanidin on Binge Ethanol ‐Induced Lipid Accumulation and ROS Overproduction via the Promotion of Hepatic Autophagy
Mol. Nutr. Food Res. 2019,63,https://doi.org/10.1002/mnfr.2018012551801255DOI:10.1002/mnfr.201801255Owing to their health promotion function, the procyanidins have long been employed as dietary supplements. In article numberhttps://doi.org/10.1002/mnfr.2018012551801255, Kaiping Wang and co ‐workers find that the dimer procyanidin may alleviate acute alcoholic liver disease via the activation of hepatocyte autophagy, providing novel insight into a strategy to fight against alcoholic liver disease. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - September 19, 2019 Category: Food Science Authors: Peng Cao, Yu Zhang, Zi Huang, Mitchell A. Sullivan, Zihao He, Jinglin Wang, Zehong Chen, Huiping Hu, Kaiping Wang Tags: Front Cover Source Type: research

Editorial Board: Mol. Nutr. Food Res. 18'19
Molecular Nutrition&Food Research, Volume 63, Issue 18, September 2019. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - September 19, 2019 Category: Food Science Tags: Editorial Board Source Type: research

The Hypoglycemic Effect of Green Tea Brewed in Cold Water is more Effective
Molecular Nutrition&Food Research, Volume 63, Issue 18, September 2019. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - September 19, 2019 Category: Food Science Authors: Jiayi Jiang Tags: Letter to the Editor Source Type: research

The Contribution of Lipids to the Inter ‐Individual Response of Vitamin K Biomarkers to Vitamin K Supplementation
We examined the association of plasma lipids and 27 lipid ‐related genetic variants with the response of biomarkers of vitamin K metabolism in a secondary analysis of data from a 3‐year phylloquinone supplementation trial in men (n=66) and women (n=85). Year 3 plasma triglycerides (TG), but not total cholesterol, LDL ‐cholesterol, or HDL‐cholesterol, were associated with the plasma phylloquinone response (Men: β=1.01, p
Source: Molecular Nutrition and Food Research - September 18, 2019 Category: Food Science Authors: Jennifer M. Kelly, Jose M. Ordovas, Gregory Matuszek, Caren E. Smith, Gordon S. Huggins, Hassan S. Dashti, Reiko Ichikawa, Sarah L. Booth Tags: Research Article Source Type: research

ω‐3 PUFAs Alleviate High‐fat Diet Induced Circadian Intestinal Microbes Dysbiosis
ConclusionOur data show that FO and AO alleviate circadian gut microbiota dysregulation in mice caused by HFD, and support the further investigation of ω‐3 PUFAs as a dietary intervention strategy for the prevention of hyperlipidemia.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - September 18, 2019 Category: Food Science Authors: Lifeng Gui, Si Chen, Hualin Wang, Mengcheng Ruan, Yang Liu, Na Li, Hongyu Zhang, Zhiguo Liu Tags: Research Article Source Type: research

Honey Polyphenols Ameliorate DSS ‐induced Ulcerative Colitis Via Modulating Gut Microbiota in Rats
ConclusionsHoney polyphenols improved intestinal inflammation and oxidative stress resistance via modulating gut microbiota, which was conducive to revealing the host ‐microbe interactions.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - September 18, 2019 Category: Food Science Authors: Haoan Zhao, Ni Cheng, Wenqi Zhou, Sinan Chen, Qian Wang, Hui Gao, Xiaofeng Xue, Liming Wu, Wei Cao Tags: Research Article Source Type: research

Wheat Protein Hydrolysate Fortified With L ‐Arginine Enhances Satiation Induced by the Capsaicinoid Nonivamide in Moderately Overweight Male Subjects
ScopeIncreasing the intake of satiety ‐enhancing food compounds represents a promising strategy for maintaining a healthy body weight. We recently demonstrated satiating effects for the capsaicinoid nonivamide. As various proteins and amino acids have also been demonstrated to decrease energy intake, we tested oGTT‐based bolus inter ventions of 75 g glucose + 0.15 mg nonivamide (NV control) with/without combination of a wheat protein hydrolysate (WPH: 2 g) and/or L‐arginine (ARG: 3.2 g) for their satiating effects in 27 moderately overweight male subjects.Methods and ResultsCompared to NV control ...
Source: Molecular Nutrition and Food Research - September 18, 2019 Category: Food Science Authors: Verena Stoeger, Barbara Lieder, Johanna Riedel, Kerstin Schweiger, Julia Hoi, Veronika Ruzsanyi, Martin Klieber, Petra Rust, Joachim Hans, Jakob P Ley, Gerhard E Krammer, Veronika Somoza Tags: Research Article Source Type: research

Dietary Supplementation of Methyl Donor L ‐Methionine Alters Epigenetic Modification in Type 2 Diabetes
ConclusionWe provide the first evidence that dietary supplementation of L ‐Met prevents diabetes‐induced epigenetic alterations and regulating methionine levels can be therapeutically exploited for the treatment of metabolic diseases.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - September 18, 2019 Category: Food Science Authors: Umashanker Navik, Vaibhav G. Sheth, Shaheen Wasil Kabeer, Kulbhushan Tikoo Tags: Research Article Source Type: research

Mannan Oligosaccharide Suppresses Lipid Accumulation and Appetite in Western ‐Diet‐Induced Obese Mice Via Reshaping Gut Microbiome and Enhancing Short‐Chain Fatty Acids Production
ConclusionMOS suppresses the appetite, which results in less lipid deposition. The lower appetite is likely due to an altered gut microbiome and elevated SCFAs production. MOS may be a potential nutraceutical used in body weight management and gut health improvement. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - September 15, 2019 Category: Food Science Authors: Shikai Yan, Renjie Shi, Ling Li, Shaobo Ma, Hongbo Zhang, Jin Ye, Jiamin Wang, Junru Pan, Qianxu Wang, Xiang Jin, Xuebo Liu, Zhigang Liu Tags: Research Article Source Type: research

Front Cover: A Two ‐Week Treatment with Plant Extracts Changes Gut Microbiota, Caecum Metabolome, and Markers of Lipid Metabolism in ob/ob Mice
Mol. Nutr. Food Res. 2019,63,https://doi.org/10.1002/mnfr.2019004031900403DOI:10.1002/mnfr.201900403In article numberhttps://doi.org/10.1002/mnfr.2019004031900403, Matteo Serino and co ‐workers find that in ob/ob mice, a two week treatment with plant extracts affects gut microbiota, caecum metabolome, markers of plasma lipid metabolism, as well as white adipose tissue and liver gene expression. These findings are depending on both the nature and dose of the tested extract. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - September 12, 2019 Category: Food Science Authors: Amandine Brochot, Vincent Azalbert, Jean ‐François Landrier, Franck Tourniaire, Matteo Serino Tags: Front Cover Source Type: research

Editorial Board: Mol. Nutr. Food Res. 17'19
Molecular Nutrition&Food Research, Volume 63, Issue 17, September 2019. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - September 12, 2019 Category: Food Science Tags: Editorial Board Source Type: research

Potential Interplay between Dietary Saturated Fats and Genetic Variants of the NLRP3 Inflammasome to Modulate Insulin Resistance and Diabetes Risk: Insights from a Meta ‐Analysis of 19 005 Individuals
The NLRP3 inflammasome is a metabolic sensor activated by saturated fatty acids initiating IL ‐1β inflammation and insulin resistance. A genome‐wide candidate meta‐analysis of NLRP3 genetic variants in 19 005 participants highlights two NLRP3 single‐nucleotide polymorphisms that interact with dietary saturated fat to increase insulin concentrations. Identifying inflammatory gene– nutrient interactions may facilitate identification of individuals at high type 2 diabetes risk. ScopeInsulin resistance (IR) and inflammation are hallmarks of type 2 diabetes (T2D). The nod ‐like receptor pyrin domain ...
Source: Molecular Nutrition and Food Research - September 12, 2019 Category: Food Science Authors: Aoife M. Murphy, Caren E. Smith, Leanne M. Murphy, Jack L. Follis, Toshiko Tanaka, Kris Richardson, Raymond Noordam, Rozenn N. Lemaitre, Mika K ähönen, Josée Dupuis, Trudy Voortman, Eirini Marouli, Dennis O. Mook‐Kanamori, Olli T. Raitak Tags: Research Article Source Type: research

Long ‐Chain n‐3 PUFA Content and n‐6/n‐3 PUFA Ratio in Mammal, Poultry, and Fish Muscles Largely Explain Differential Protein and Lipid Oxidation Profiles Following In Vitro Gastrointestinal Digestion
ConclusionsMuscular fatty acid profiles largely explain type and extent of lipid and protein oxidation during gastrointestinal digestion. Red meat only stimulates oxidation when digested with specific fat sources. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - September 12, 2019 Category: Food Science Authors: Thomas Van Hecke, Sophie Goethals, Els Vossen, Stefaan De Smet Tags: Research Article Source Type: research

Coenzyme Q10 up ‐regulates Platelet cAMP/PKA Pathway and Attenuates Integrin αIIbβ3 Signaling and Thrombus Growth
ConclusionThrough up ‐regulating the platelet cAMP/PKA pathway, and attenuating αIIbβ3 signaling and thrombus growth, CoQ10 supplementation may play an important protective role in patients with risks of cardiovascular diseases.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - September 12, 2019 Category: Food Science Authors: Fuli Ya, Xiaohong Ruby Xu, Yilin Shi, Reid C. Gallant, Fenglin Song, Xiao Zuo, Yimin Zhao, Zezhong Tian, Cheng Zhang, Xiping Xu, Wenhua Ling, Heyu Ni, Yan Yang Tags: Research Article Source Type: research

Tomatidine Reduces Palmitate ‐Induced Lipid Accumulation by Activating AMPK via Vitamin D Receptor‐Mediated Signaling in Human HepG2 Hepatocytes
ConclusionThe in vitro study suggests the potential efficacy of tomatidine as a preventive and therapeutic treatment in obesity ‐related fatty liver diseases. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - September 10, 2019 Category: Food Science Authors: Hikari Kusu, Hiroki Yoshida, Michiko Kudo, Mai Okuyama, Naoki Harada, Kentaro Tsuji ‐Naito, Mitsugu Akagawa Tags: Research Article Source Type: research

Maternal Overfeeding during Lactation Impairs the Metabolic Response to Fed/Fasting Changing Conditions in the Postweaning Offspring
ConclusionMaternal intake of a cafeteria diet during lactation causes early alterations in the offspring, impairing their metabolic flexibility in response to fed/fasting changing conditions, which may contribute to hindering energy homeostasis maintenance. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - September 6, 2019 Category: Food Science Authors: Catalina Amadora Pomar, Heriberto Castro, Catalina Pic ó, Andreu Palou, Juana Sánchez Tags: Research Article Source Type: research

Mannan Oligosaccharide Suppresses Lipid Accumulation and Appetite in Western Diet ‐Induced Obese Mice Via Reshaping Gut Microbiome and Enhancing Short‐Chain Fatty Acids Production
ConclusionMOS suppressed the appetite, which resulted in less lipid deposition. The lower appetite was likely due to an altered gut microbiome and elevated SCFAs production. MOS might be a potential nutraceutical used in bodyweight management and gut health improvement.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - September 5, 2019 Category: Food Science Authors: Shikai Yan, Renjie Shi, Ling Li, Shaobo Ma, Hongbo Zhang, Jin Ye, Jiamin Wang, Junru Pan, Qianxu Wang, Xiang Jin, Xuebo Liu, Zhigang Liu Tags: Research Article Source Type: research

GutSelf: Inter ‐Individual Variability in the Processing of Dietary Compounds by the Human Gastrointestinal Tract
This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - September 4, 2019 Category: Food Science Authors: Barbara Walther, Aaron M. Lett, Alessandra Bordoni, Lidia Tom ás‐Cobos, Juan Antonio Nieto, Didier Dupont, Francesca Danesi, Danit R. Shahar, Ana Echaniz, Roberta Re, Aida Sainz Fernandez, Amélie Deglaire, Doreen Gille, Alexandra Schmid, Tags: Review Source Type: research

Long Chain n ‐3 PUFA Content and n‐6/n‐3 PUFA Ratio in Mammal, Poultry and Fish Muscles Largely Explain Differential Protein and Lipid Oxidation Profiles Following in vitro Gastrointestinal Digestion
ConclusionsMuscular fatty acid profiles largely explained type and extent of lipid and protein oxidation during gastrointestinal digestion. Red meat only stimulated oxidation when digested with specific fat sources.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - September 4, 2019 Category: Food Science Authors: Thomas Van Hecke, Sophie Goethals, Els Vossen, Stefaan De Smet Tags: Research Article Source Type: research

A Metabolomic Study of Biomarkers of Habitual Coffee Intake in Four European Countries
ScopeThe goal of this work was to identify circulating biomarkers of habitual coffee intake using a metabolomic approach, and to investigate their associations with coffee intake in four European countries.Methods and resultsUntargeted mass spectrometry ‐based metabolic profiling was performed on serum samples from 451 participants of the European Prospective Investigation on Cancer and Nutrition (EPIC) originating from France, Germany, Greece and Italy. Eleven coffee metabolites were found to be associated with self‐reported habitual coffee in take, including 8 more strongly correlated (r = 0.25‐0.51,P
Source: Molecular Nutrition and Food Research - September 4, 2019 Category: Food Science Authors: Joseph A. Rothwell, Pekka Keski ‐Rahkonen, Nivonirina Robinot, Nada Assi, Corinne Casagrande, Mazda Jenab, Pietro Ferrari, Marie‐Christine Boutron‐Ruault, Yahya Mahamat‐Saleh, Francesca Romana Mancini, Heiner Boeing, Verena Katzke, Til Tags: Research Article Source Type: research

Eucalyptol Ameliorates Dysfunction of Actin Cytoskeleton Formation and Focal Adhesion Assembly in Glucose ‐Loaded Podocytes and Diabetic Kidney
ConclusionEucalyptol ameliorated F ‐actin cytoskeleton formation and focal adhesion assembly through blockade of Rho signaling pathway entailing partial involvement of GSK3β, which may inhibit barrier dysfunction of podocytes and resultant proteinuria.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - September 4, 2019 Category: Food Science Authors: Dong Yeon Kim, Min ‐Kyung Kang, Yun‐Ho Kim, Eun‐Jung Lee, Hyeongjoo Oh, Soo‐Il Kim, Su Yeon Oh, Young‐Hee Kang Tags: Research Article Source Type: research

Omics Insights into Metabolic Stress and Resilience of Rats in Response to Short ‐term Fructose Overfeeding
ConclusionOur findings indicate that SFO disturbs metabolic homeostasis and that endogenous small molecules positively mediate SFO induced metabolic adaption. Our results also underline that an inherent regulatory mechanism of resilience occurs in response to fructose overconsumption, suggesting that efforts to maintain resilience could be a promising target to prevent and treat metabolic disorder ‐like conditions.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - September 3, 2019 Category: Food Science Authors: Kun ‐Ping Li, Min Yuan, Zhuo‐Ru He, Qi Wu, Chu‐Mei Zhang, Zhi‐Li Lei, Xiang‐Lu Rong, Zebo Huang, Jeremy E. Turnbull, Jiao Guo Tags: Research Article Source Type: research

Glycerol ‐Monolaurate‐Mediated Attenuation of Metabolic Syndrome is Associated with the Modulation of Gut Microbiota in High‐Fat‐Diet‐Fed Mice
ConclusionThe findings identify the links between gut microbiota and GML ‐induced metabolic improvements, suggesting that the attenuation of HFD‐induced metabolic disorders by higher GML supplementation may occur through targeting gut microbiota. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - August 29, 2019 Category: Food Science Authors: Minjie Zhao, Haiying Cai, Zengliang Jiang, Yang Li, Hao Zhong, Hui Zhang, Fengqin Feng Tags: Research Article Source Type: research

Tomatidine, a Steroidal Alkaloid from Green Tomatoes, Reduces Palmitate ‐Induced Lipid Accumulation by Activating AMPK via Vitamin D Receptor‐Mediated Signaling in Human HepG2 Hepatocytes
ConclusionOurin vitro study suggests the potential efficacy of tomatidine as a preventive and therapeutic treatment in obesity ‐related fatty liver diseases.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - August 27, 2019 Category: Food Science Authors: Hikari Kusu, Hiroki Yoshida, Michiko Kudo, Mai Okuyama, Naoki Harada, Kentaro Tsuji ‐Naito, Mitsugu Akagawa Tags: Research Article Source Type: research

Punicalagin, a Pomegranate ‐Derived Ellagitannin, Suppresses Obesity and Obesity‐Induced Inflammatory Responses Via the Nrf2/Keap1 Signaling Pathway
ConclusionsPCG ameliorated obesity and obesity ‐induced inflammatory responses via activation of Nrf2/Keap1 signaling, suggesting that PCG has potential as an oral agent to control obesity‐mediated diseases.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - August 24, 2019 Category: Food Science Authors: Bobin Kang, Chae Young Kim, Jisu Hwang, Kyungae Jo, Singeun Kim, Hyung Joo Suh, Hyeon ‐Son Choi Tags: Research Article Source Type: research

Malvidin 3 ‐Glucoside Modulated Gut Microbial Dysbiosis and Global Metabolome Disrupted in a Murine Colitis Model Induced by Dextran Sulfate Sodium
ConclusionMV ingestion ameliorated intestinal inflammation by modulating colon epithelium integrity, gut microbiome, and key inflammatory mediators.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - August 24, 2019 Category: Food Science Authors: Fang Liu, Thomas T. Y. Wang, Qingjuan Tang, Changhu Xue, Robert W. Li, Vivian C.H. Wu Tags: Research Article Source Type: research

Front Cover: Beneficial Effects of Pomegranate on Lipid Metabolism in Metabolic Disorders
Mol. Nutr. Food Res. 2019,63,https://doi.org/10.1002/mnfr.2018007731800773DOI:10.1002/mnfr.201800773In article numberhttps://doi.org/10.1002/mnfr.2018007731800773, Jianke Li and co ‐workers show that in metabolic‐disorder‐associated diseases the effects of pomegranate extracts on the regulation of lipid metabolism imbalances are most likely achieved by alleviating cellular oxidative and inflammatory damage and improving mitochondrial metabolism. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - August 22, 2019 Category: Food Science Authors: Chen Hou, Weimin Zhang, Jianke Li, Lin Du, Ou Lv, Shengjuan Zhao, Jia Li Tags: Front Cover Source Type: research

Editorial Board: Mol. Nutr. Food Res. 16'19
Molecular Nutrition&Food Research, Volume 63, Issue 16, August 2019. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - August 22, 2019 Category: Food Science Tags: Editorial Board Source Type: research