Organic Cation Transporter I and Na+/taurocholate Co ‐Transporting Polypeptide are Involved in Retrorsine‐ and Senecionine‐Induced Hepatotoxicity in HepaRG cells
ConclusionOur results confirmed previous findings of active transport mechanisms of PAs into hepatocytes and highlight the importance of toxicokinetic studies for the risk assessment of PAs.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 26, 2021 Category: Food Science Authors: Anne ‐Margarethe Enge, Florian Kaltner, Christoph Gottschalk, Angelina Kin, Michael Kirstgen, Joachim Geyer, Anja These, Helen Hammer, Oliver Pötz, Albert Braeuning, Stefanie Hessel‐Pras Tags: Research Article Source Type: research

Prevention of Atopic Dermatitis in Mice by Lactobacillus Reuteri Fn041 Through Induction of Regulatory T Cells and Modulation of the Gut Microbiota
ConclusionsOur study strengthens the understanding that breast milk-derived sIgA coated potential probiotics are involved in the development of infant intestinal microbiota, thus promoting immune development and preventing allergic diseases, and expanding the knowledge of breast milk sIgA and bacterial interactions on infant immune development.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 26, 2021 Category: Food Science Authors: Yuning Zhao, Ce Qi, Xinyue Li, Mengyao Lu, Haowen Zhang, Jingbo Zhou, Hongyang Dang, Jie Chen, Shuangqi Li, Jin Sun, Renqiang Yu, Duo Li Tags: Research Article Source Type: research

VF ‐4 and DR‐8 derived from salted egg white inhibit inflammatory activity via NF‐κB/PI3K‐Akt/MAPK signal transduction pathways in HT‐29 cells induced by TNF‐α
Conclusion: VF-4 and DR-8 have obvious anti-inflammatory activity, which can reduce intestinal inflammation and inhibit its further development into colon cancer.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 25, 2021 Category: Food Science Authors: Na Zhou, Yao Yao, Na Wu, Huaying Du, Mingsheng Xu, Yan Zhao, Yonggang Tu Tags: Research Article Source Type: research

Ex Vivo Faecal Fermentation of human Ileal Fluid Collected After Wild Strawberry Consumption Modulates Human Microbiome Community Structure and Metabolic Output and Protects Against DNA Damage in Colonic Epithelial Cells
AbstractScopeWild strawberries (Fragaria vesca) are richer in (poly)phenols than common commercial strawberry varieties, e.g.,Fragaria × ananassa. (Poly)phenols and their microbiota-derived metabolites are hypothesised to exert bioactivity within the human gut mucosa. To address this, the effects of wild strawberries were investigated with respect to their bioactivity and microbiota-modulating capacity using both in vitro andex vivo approaches.Methods and resultsIleal fluids collected pre- (0h) and post-consumption (8h) of 225  g wild strawberries by ileostomates (n = 5) and also in vitro digested strawberry var...
Source: Molecular Nutrition and Food Research - November 25, 2021 Category: Food Science Authors: Camilla Diotallevi, Massimiliano Fontana, Cheryl Latimer, Nigel G. Ternan, L. Kirsty Pourshahidi, Roger Lawther, Gloria O'Connor, Lorenza Conterno, Mattia Gasperotti, Andrea Angeli, Cesare Lotti, Martina Bianchi, Urska Vrhovsek, Francesca Fav Tags: Research Article Source Type: research

Imbalanced folate and vitamin B12 in the 3rd trimester of pregnancy and its association with birthweight and child growth up to 2 years
Scope: Folic acid supplementation during pregnancy may lead to an imbalance when vitamin B12 intake is low (folate trap) and may affect child's growth.Methods: We studied the association between 3rd trimester maternal intakes of folate and B12 and birthweight and postnatal growth of 2,632 infants from the KOALA Birth Cohort Study. Plasma vitamin biomarkers were measured in 1219 women.Results: Imbalanced total intakes (folate>  430 μg/d combined with B12  745 nmol/L and plasma B12
Source: Molecular Nutrition and Food Research - November 25, 2021 Category: Food Science Authors: Rima Obeid, Simone JPM Eussen, Monique Mommers, Luc Smits, Carel Thijs Tags: Research Article Source Type: research

Back Cover: Dietary Naringenin Preserves Insulin Sensitivity and Grip Strength and Attenuates Inflammation but Accelerates Weight Loss in a Mouse Model of Cancer Cachexia
Mol. Nutr. Food Res. 2021,65,202100268DOI:10.1002/mnfr.202100268In article number2100268, Martha A. Belury and co-workers found that dietary supplementation of naringenin improves multiple aspects of metabolic disturbance during cancer cachexia progression in the C-26 mouse model. The cover image by graphic designer Pamela Galante is a pattern depicting food sources of naringenin, the metabolic interplay between tumor, adipose, and muscle tissues, inflammation, and the insulin receptor. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 23, 2021 Category: Food Science Authors: Deena B. Snoke, Yuko Nishikawa, Rachel M. Cole, Ai Ni, Austin Angelotti, Yael Vodovotz, Martha A. Belury Tags: Back Cover Source Type: research

Front Cover: KFP ‐1, a Novel Calcium‐Binding Peptide Isolated from Kefir, Promotes Calcium Influx Through TRPV6 Channels
Mol. Nutr. Food Res. 2021,65,202100182DOI:10.1002/mnfr.202100182A novel kefir-fermented peptide (KFP-1) is identified as a calcium-binding peptide with the function to enhance intestinal calcium absorption through TRPV6 channels. This KFP-1 peptide exhibits the potential as a nutraceutical additive to alleviate the condition of calcium deficiency and the osteoporosis-related illnesses. This is reported by Hueng-Chuen Fan, Chuan-Mu Chen, and co-workers in article number2100182. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 23, 2021 Category: Food Science Authors: Gary Ro ‐Lin Chang, Min‐Yu Tu, Yu‐Hsuan Chen, Ku‐Yi Chang, Chien‐Fu Chen, Jen‐Chieh Lai, Yu‐Tang Tung, Hsiao‐Ling Chen, Hueng‐Chuen Fan, Chuan‐Mu Chen Tags: Front Cover Source Type: research

Editorial Board: Mol. Nutr. Food Res. 22'21
(Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 23, 2021 Category: Food Science Tags: Editorial Board Source Type: research

Alginate and its two Components Acted Differently Against Dopaminergic Neuronal Loss in Parkinson's Disease Mice Model
ConclusionPM played better than PG to provide neuroprotection, but Alg did not show any neuroprotection against PD. Alg and its two components acted differently in preventing dopaminergic neuronal loss in PD mice.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 23, 2021 Category: Food Science Authors: Zhong ‐Rui Du, Xiong Wang, Xu Cao, Xin Liu, Sai‐Nan Zhou, Hui Zhang, Rui‐Li Yang, Ka‐Hing Wong, Qing‐Juan Tang, Xiao‐Li Dong Tags: Research Article Source Type: research

Comparative Analysis of the Effects of Fish oil and Fenofibrate on Plasma Metabolomic Profiles in Overweight and Obese Individuals
Scope: The drug fenofibrate and dietary fish oils can effectively lower circulating triglyceride (TG) concentrations. However, a detailed comparative analysis of the effects on the plasma metabolome is missing.Methods and resultsTwenty overweight and obese subjects participated in a double-blind, cross-over intervention trial and received in random order 3.7  g/d n-3 fatty acids, 200 mg fenofibrate, or placebo treatment for 6 weeks. 420 plasma metabolites were measured via GC-MS and LC-MS. Among the treatments, 237 metabolites were significantly different, of which 22 metabolites changed in the same direction by ...
Source: Molecular Nutrition and Food Research - November 23, 2021 Category: Food Science Authors: Charlotte C.J.R. Michielsen, Roland W.J. Hangelbroek, Marjolijn C.E. Bragt, Elwin R. Verheij, Suzan Wopereis, Ronald P. Mensink, Lydia A. Afman Tags: Research Article Source Type: research

Effect of Lactobacillus rhamnosus MN ‐431 producing indole derivatives on complementary feeding‐induced diarrhea rat pups through the enhancement of the intestinal barrier function
Conclusion: The results demonstrated thatL. rhamnosus MN-431 can metabolize tryptophan to prevent infantile CFID by promoting the expression of PXR.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 22, 2021 Category: Food Science Authors: Haiyue Niu, Xiaohong Zhou, Pimin Gong, Yuehua Jiao, Jiliang Zhang, Yifan Wu, Linzheng Lyu, Cong Liang, Shiwei Chen, Xue Han, Lanwei Zhang Tags: Research Article Source Type: research

Recent Advances in Research on Polyphenols: Effects on Microbiota, Metabolism and Health
This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 22, 2021 Category: Food Science Authors: Hiba N. Rajha, Armelle Paule, Gerard Aragon ès, Mariana Barbosa, Carla Caddeo, Espérance Debs, Rada Dinkova, Gunter P. Eckert, Ariel Fontana, Prisca Gebrayel, Richard G. Maroun, Alessandra Napolitano, Lucia Panzella, Giulio Maria Pasinetti, Tags: Review Source Type: research

Targeting AMPK Signaling by Dietary Polyphenols in Cancer Prevention
This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 21, 2021 Category: Food Science Authors: Zuomin Hu, Mengyuan Li, Yunyun Cao, Otobong Donald Akan, Tianyi Guo, Feijun Luo Tags: Review Source Type: research

Lactobacillus rhamnosus strain LRH05 intervention ameliorated body weight gain and adipose inflammation via modulating the gut microbiota in high ‐fat diet‐induced obese mice
ConclusionLRH05 showed a strain-specific effect on ameliorating the pro-inflammatory process by reducing inflammatory macrophage infiltration and the expression of inflammation-related genes in mice. Thus, LRH05 could be considered a potential probiotic strain to prevent obesity. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 19, 2021 Category: Food Science Authors: Yung ‐Tsung Chen, Shiou‐Yun Chiou, Ai‐Hua Hsu, Yu‐Chun Lin, Jin‐Seng Lin Tags: Research Article Source Type: research

Development of a Food Composition Database for Assessing Nitrate and Nitrite Intake from Animal ‐based Foods
ConclusionThis database can now be used to investigate the associations between nitrate and nitrite dietary intake and health outcomes in clinical trials and observational studies.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 18, 2021 Category: Food Science Authors: Liezhou Zhong, Alex H. Liu, Lauren C. Blekkenhorst, Nicola P. Bondonno, Marc Sim, Richard J. Woodman, Kevin D. Croft, Joshua R. Lewis, Jonathan M. Hodgson, Catherine P. Bondonno Tags: Research Article Source Type: research

AKT1/HK2 Axis ‐mediated Glucose Metabolism: A Novel Therapeutic Target of Sulforaphane in Bladder Cancer
ConclusionsSFN down-regulated the unique glucose transport aberrant-independent aerobic glycolysis existed in bladder cancer via blocking the AKT1/HK2 axis and PDH expression.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 18, 2021 Category: Food Science Authors: Lei Huang, Canxia He, Sicong Zheng, Chao Wu, Minghua Ren, Yujuan Shan Tags: Research Article Source Type: research

Impacts of Enriched Human Milk Cells on Fecal Metabolome and Gut Microbiome of Premature Infants with Stage I Necrotizing Enterocolitis: A Pilot Study
ConclusionThese preliminary findings reveal the potential impacts of enriched human milk cells on premature infants with Bell's Stage I NEC and provide insight into the roles of fecal sphingolipid metabolism in the neonates ’ intestinal inflammation. However, the limited sample size of the study indicates the need for further investigation.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 17, 2021 Category: Food Science Authors: Luyang Hong, Lan Zhang, Qi Zhou, Shujuan Li, Junyan Han, Siyuan Jiang, Xiao Han, Yi Yang, Shangyu Hong, Yun Cao Tags: Research Article Source Type: research

Short ‐Chain Fatty Acids Produced by Ruminococcaceae Mediate α‐Linolenic Acid Promote Intestinal Stem Cells Proliferation
Conclusion: These results indicate that SCFAs produced by Ruminococcaceae mediate ALA promote ISCs proliferation by activating the Wnt/ β-catenin signaling pathway, and suggest the possibility of ALA as a prebiotic agent for the prevention and treatment of intestinal mucositis. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 17, 2021 Category: Food Science Authors: Jing Xie, Ling ‐fei Li, Tian‐yi Dai, Xin Qi, Yan Wang, Tiao‐zhen Zheng, Xiao‐yu Gao, Yun‐juan Zhang, Yu Ai, Li Ma, Song‐lin Chang, Feng‐xian Luo, Yang Tian, Jun Sheng Tags: Research Article Source Type: research

Dose Dependent Effects of Fructose and Glucose on de novo Palmitate and Glycerol Synthesis in an Enterocyte Cell Model
ScopeFructose exacerbates post-prandial hypertriacylglycerolaemia. This may be partly due to increased enterocyte de novo lipogenesis (DNL). It is unknown whether this is concentration-dependent or whether fructose has a greater effect on lipid synthesis than glucose. The dose-dependent effects of fructose and glucose on DNL and de novo triacylglycerol (TAG)-glycerol synthesis were investigated in an enterocyte model; Caco-2 cells.Methods and resultsCaco-2 cells were treated for 96h with 5mM,  25mM or 50mM fructose or glucose, or 12.5mM fructose/12.5mM glucose mix. DNL was measured follow...
Source: Molecular Nutrition and Food Research - November 17, 2021 Category: Food Science Authors: Simon Steenson, Fariba Shojaee ‐Moradie, Julie A. Lovegrove, A. Margot Umpleby, Kim G. Jackson, Barbara A. Fielding Tags: Research Article Source Type: research

Cysteine exerts an essential role in maintaining intestinal integrity and function independent of glutathione
Conclusion: Adequate dietary cysteine supply is essential for intestinal mucosal integrity, epithelial cell turnover and amino acid sensing as well as optimal individual growth. Cysteine exerts its role independent of glutathione and glutathione restores the impairment of cysteine-deprivation on intestinal mucosal through degrading into cysteine.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 17, 2021 Category: Food Science Authors: Ning Jiao, Lu Wang, Yubo Wang, Doudou Xu, Xin Zhang, Jingdong Yin Tags: Research Article Source Type: research

Oxidized Pork Induces Hepatic Steatosis by Impairing Thyroid Hormone Function in Mice
ConclusionHOP intake could induce hepatic steatosis by impairing TH function. Dityr plays an important role in the HOP-induced harmful effects.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 17, 2021 Category: Food Science Authors: Yueting Ge, Yuhui Yang, Yuge Jiang, Chuanxing Feng, Bowen Li, Jin Sun, Xue Tang, Yonghui Shi, Guowei Le Tags: Research Article Source Type: research

Yellow yeast rice prepared using Aspergillus terreus DSMK01 lowers cholesterol levels by stimulating bile salt export pump in subjects with mild ‐to‐moderate hypercholesterolemia: a randomized controlled trial
Conclusion: These findings suggest that daily YYR supplementation exerted hypocholesterolemic effects in mild-to-moderate hypocholesterolemic subjects by reducing intrahepatic cholesterol availability through stimulating bile salt export pumps and inhibiting cholesterol biosynthesis.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 16, 2021 Category: Food Science Authors: Seunghee Kang, Eunok Lee, Heeyeon Lee, Geum ‐Sook Hwang, Jaekyung Lee, Ji Won Kim, Bumjo Oh, Ji Yeon Kim, Oran Kwon Tags: Research Article Source Type: research

Lycopene Regulates Dietary Dityrosine ‐Induced Mitochondrial‐Lipid Homeostasis by Increasing Mitochondrial Complex Activity
ConclusionLycopene improves DT-mediated myocardial energy homeostasis disorder by promoting the activity of respiratory chain complexes I and IV and alleviates the accumulation of cardiac fatty acids and myocardial hypertrophy. This study will benefit to further clarify the molecular mechanism by which DT affects energy metabolism and the potential intervention of lycopene in reducing health hazards of food oxidized proteins.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 16, 2021 Category: Food Science Authors: Jun Wang, Xue Tang, Yipin Lu, Yingying Zheng, Fanhang Zeng, Wentao Shi, Peng Zhou Tags: Research Article Source Type: research

Effect of Reversal of Whey ‐Protein to Casein Ratio of Cow Milk, on Insulin, Incretin, and Amino Acid Responses in Humans
The reversal of the WP/Cas ratio in cow milk at iso-lactose and isoproteic loads, enhanced insulin and incretin secretion, possibly mediated by plasma total (and branched chain) response(s), and proportionally to the same extent of that of published studies using pure protein preparations, thus excluding a significant protein-to-protein interaction. ScopeMilk-proteins, besides lactose, stimulate insulin and incretin secretion. Although whey-proteins (WP) are more efficient than casein (Cas) in hormone secretion, the effects of reversal of the (WP/Cas) ratio in whole-milk are poorly known.Methods and ResultsHealthy voluntee...
Source: Molecular Nutrition and Food Research - November 15, 2021 Category: Food Science Authors: Alessandro Toffolon, Maurizio Rocco ‐Ponce, Monica Vettore, Elisabetta Iori, Anna Lante, Paolo Tessari Tags: Research Article Source Type: research

Effects of emulsifiers on an in vitro model of intestinal epithelial tight junctions and the transport of food allergens
AbstractScope: Certain food emulsifiers may interfere with gut barrier function in ways correlating to increased exposure to allergens. Understanding the consequences of interactions between these food ingredients and the intestinal epithelium is important for evaluating allergen dose exposure characteristics. Methods and Results: Wechallenged Caco-2 cell monolayers, an in vitromodel of human intestinal epithelial tight junctions with synthetic polysorbate-80 or natural lecithin alone, or in combination with known allergens (egg proteins: ovalbumin, ovomucoid, and ovotransferrin; and a synthetic form of galactose-alpha-1,3...
Source: Molecular Nutrition and Food Research - November 15, 2021 Category: Food Science Authors: Sefat E Khuda, Ann V. Nguyen, Girdhari M. Sharma, Mohammad S. Alam, Kannan V. Balan, Kristina M. Williams Tags: Research Article Source Type: research

Cardiovascular Benefits of Phenol ‐Enriched Virgin Olive Oils: New Insights from the Virgin Olive Oil and HDL Functionality (VOHF) Study
(Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 15, 2021 Category: Food Science Authors: Anna Pedret, Sara Fern ández‐Castillejo, Rosa‐Maria Valls, Úrsula Catalán, Laura Rubió, Marta Romeu, Alba Macià, Maria Carmen López de las Hazas, Marta Farràs, Montse Giralt, Juana I. Mosele, Sandra Martín‐Peláez, Alan T. Remale Tags: Erratum Source Type: research

Flavonoid ‐like Components of Peanut Stem and Leaf Extract Promote Sleep by Decreasing Neuronal Excitability
ConclusionsDMN and MIL are the active ingredients of PSL that improve sleep quality, suggesting that PSL promotes sleep by regulating the excitability of neurons.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 12, 2021 Category: Food Science Authors: Rui Guo, Ai ‐min Shi, Lei Deng, Lei Li, Lie‐chen Wang, Antwi‐Boaisko Oteng, Meng‐ping Wei, Zhi‐hao Zhao, Guido Hooiveld, Chen Zhang, Qiang Wang Tags: Research Article Source Type: research

Front Cover: Faecalibacterium prausnitzii Attenuates DSS ‐Induced Colitis by Inhibiting the Colonization and Pathogenicity of Candida albicans
Mol. Nutr. Food Res. 2021,65,202100433DOI:10.1002/mnfr.202100433Intestinal commensal microbiota play critical roles in the gut, but little is known about the intestinal bacterial-fungal interactions. In article numbermnfr.202100433, Xinyun Qiu and co-workers observeFaecalibacterium prausnitzii can antagonize hyphal transformation, virulence, and growth ofCandida albicans, promote the production of anti-inflammation cytokines, antibacterial peptides and inhibitC. albicans colonization in the gut, thus improve intestinal inflammation. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 4, 2021 Category: Food Science Authors: Xiaqiong Mao, Jingjing Ma, Chunhua Jiao, Nana Tang, Xiaojing Zhao, Di Wang, Yue Zhang, Ziping Ye, Chenjing Xu, Jingyue Jiang, Shasha Wu, Xiufang Cui, Hongjie Zhang, Xinyun Qiu Tags: Front Cover Source Type: research

Editorial Board: Mol. Nutr. Food Res. 21'21
(Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 4, 2021 Category: Food Science Tags: Editorial Board Source Type: research

Detection of a Hemoglobin Adduct of  the Food Contaminant Furfuryl Alcohol in Humans: Levels of N‐((Furan‐2‐yl)methyl)‐valine in Two Epidemiological Studies
This study analyzed human erythrocyte samples from two studies for the presence of FFA-Val: theRisks and Benefits of a Vegan Diet study (RBVD; 72 adults) and the ENVIRonmental influenceON early AGEing birth cohort study (ENVIRONAGE; 100 mother-newborn pairs). In the RBVD study, FFA-Val levels are lower in vegans compared to omnivores (median 13.0 vs 15.8  pmol g−1 hemoglobin,p = 0.008), and lower in non-smokers compared to smokers (median 14.1 vs 17.0  pmol g−1 hemoglobin,p = 0.003). In the birth cohort, FFA-Val levels are distinctly higher in maternal compared to newborn samples (median 15.2 vs 2.2 &...
Source: Molecular Nutrition and Food Research - November 1, 2021 Category: Food Science Authors: Bernhard H. Monien, Nick Bergau, Janneke G. F. Hogervorst, Tim S. Nawrot, Iris Trefflich, Cornelia Weikert, Klaus Abraham Tags: Research Article Source Type: research

Allulose Attenuated Age ‐Associated Sarcopenia via Regulating IGF‐1 and Myostatin in Aged Mice
ConclusionOur findings suggested that allulose improved the age-associated sarcopenia with enhancing antioxidant properties by altering mRNA and protein expression.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 29, 2021 Category: Food Science Authors: Ji ‐Eun Kim, Eun‐Young Kwon, Youngji Han Tags: Research Article Source Type: research

Short ‐chain fatty acids produced by Ruminococcaceae mediates α‐Linolenic acid promote intestinal stem cells proliferation
Conclusion: These results indicate that SCFAs produced by Ruminococcaceae mediates ALA promote ISCs proliferation by activating Wnt/ β-catenin signaling pathway, and suggest the possibility of ALA as a prebiotic agent for the prevention and treatment of intestinal mucositis.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 28, 2021 Category: Food Science Authors: Jing Xie, Ling ‐fei Li, Tian‐yi Dai, Xin Qi, Yan Wang, Tiao‐zhen Zheng, Xiao‐yu Gao, Yun‐juan Zhang, Yu Ai, Li Ma, Song‐lin Chang, Feng‐xian Luo, Yang Tian, Jun Sheng Tags: Research Article Source Type: research

Food and Microbiota Metabolites Associate with Cognitive Decline in Older Subjects: A 12 ‐Year Prospective Study
ConclusionThese results provide insight into the early metabolic events that are associated with the later risk to develop cognitive decline within the crosstalk between diet, gut microbiota and the endogenous metabolism, which can help identify potential targets for preventive and therapeutic strategies to preserve cognitive health. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 28, 2021 Category: Food Science Authors: Ra úl González‐Domínguez, Pol Castellano‐Escuder, Francisco Carmona, Sophie Lefèvre‐Arbogast, Dorrain Y. Low, Andrea Du Preez, Silvie R. Ruigrok, Claudine Manach, Mireia Urpi‐Sarda, Aniko Korosi, Paul J. Lucassen, Ludwig Aigner, Me Tags: Research Article Source Type: research

Replacing saturated fat with polyunsaturated fat modulates peripheral blood mononuclear cell gene expression and pathways related to cardiovascular disease risk using a whole transcriptome approach
AbstractScopeThe aim of this study was to explore the molecular mechanisms underlying the effect of replacing dietary saturated fat (SFA) with polyunsaturated fat (PUFA) on cardiovascular disease (CVD) risk using a whole transcriptome approach.Methods and resultsHealthy subjects with moderate hypercholesterolemia (n = 115) were randomly assigned to a control diet (C-diet) group or an experimental diet (Ex-diet) group receiving comparable food items with different fatty acid composition for eight weeks. RNA isolated from peripheral blood mononuclear cells (PBMC) at baseline and after eight weeks of intervention was analyzed...
Source: Molecular Nutrition and Food Research - October 28, 2021 Category: Food Science Authors: Sunniva V. Larsen, Kirsten B. Holven, Jacob J. Christensen, Arnar Flatberg, Amanda Rundblad, Lena Leder, Rune Blomhoff, Vibeke Telle ‐Hansen, Marjukka Kolehmainen, Carsten Carlberg, Mari C. Myhrstad, Magne Thoresen, Stine M. Ulven Tags: Research Article Source Type: research

Acid Hydrolysis of Gluten Enhances the Skin Sensitizing Potential and Drives Diversification of IgE Reactivity to Unmodified Gluten Proteins
ConclusionAcid hydrolysis enhances the skin sensitizing capacity of gluten and drives IgE reactivity to more gluten proteins. This property of acid hydrolyzed gluten may be related to the degree of product deamidation, and could be a strong trigger of wheat allergy in susceptible individuals. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 28, 2021 Category: Food Science Authors: Anne ‐Sofie Ravn Ballegaard, Laure Castan, Jeppe Madura Larsen, Cristian Piras, Clélia Villemin, Daniel Andersen, Charlotte Bernhard Madsen, Paola Roncada, Susanne Brix, Sandra Denery‐Papini, Gabriel Mazzucchelli, Grégory Bouchaud, Katri Tags: Research Article Source Type: research

Applications and Mechanism of 3 ‐Hydroxybutyrate (3HB) for Prevention of Colonic Inflammation and Carcinogenesis as a Food Supplement
This study observes that 3HB cures mouse colitis and reduces their colorectal carcinogenesis. The mechanism was found to relate to 3HB cellular surface receptor GPR109a which can down-regulate NF- κB pathway, so as to decrease the percentage of M1 macrophages from 50% of dextran sulfate sodium salt (DSS) induced acute colitis mouse group to 42% DSS+3HB group mediating the inhibitory effect on the inflammation. The activation of GPR109a was also found to inhibit colonic carcinogenesis, depend ed on reduced myeloid derived suppressor cells (MDSCs) accumulation from 27% of DSS group to 19% of DSS+3HB group. The study co...
Source: Molecular Nutrition and Food Research - October 27, 2021 Category: Food Science Authors: Zihua Li, Shujie Zhang, Yudian Zhang, Jin Chen, Fuqing Wu, Gang Liu, Guo ‐Qiang Chen Tags: Research Article Source Type: research

Cereal Vinegar sediment alleviates spontaneous ulcerative colitis in Il ‐10 deficient mice
Conclusion: This study demonstrated that CVS ameliorates spontaneous ulcerative colitis inIl-10−/− mice, which suggests CVS supplementation may serve as a protective dietary nutrient against colitis.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 26, 2021 Category: Food Science Authors: Yan Geng, Yuanjia Yue, Qijie Guan, Yilin Ren, Lin Guo, Yifei Fan, Zhen ‐Ming Lu, Jin‐Song Shi, Zheng‐Hong Xu Tags: Short Communication Source Type: research

Angiotensin receptor blockers potentiate the protective effect of branched ‐chain amino acids on skeletal muscle atrophy in cirrhotic rats
ConclusionThese results indicate that this regimen could serve as a novel treatment for patients with sarcopenia and liver cirrhosis.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 23, 2021 Category: Food Science Authors: Soichi Takeda, Kosuke Kaji, Norihisa Nishimura, Masahide Enomoto, Yuki Fujimoto, Koji Murata, Hiroaki Takaya, Hideto Kawaratani, Kei Moriya, Tadashi Namisaki, Takemi Akahane, Hitoshi Yoshiji Tags: Research Article Source Type: research

Haematococcus pluvialis extends yeast lifespan and improves Slc25a46 gene knockout ‐associated mice phenotypic defects
Conclusions: This work highlights that the mitochondria may be a potential therapeutic target for combating aging, and demonstrated thatH. pluvialis, as a dietary supplement, may potentially be an effective preventive substance that may contribute to the promotion of healthy aging.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 21, 2021 Category: Food Science Authors: Min Wang, Piao Xu, Linfeng Liao, Li Gao, William Kwame Amakye, Ying Zhang, Maojin Yao, Jiaoyan Ren Tags: Research Article Source Type: research

Sex ‐specific Neurotoxicity of Dietary Advanced Glycation end Products in APP/PS1 Mice and Protective Roles of Trehalose by Inhibiting Tau Phosphorylation Via GSK‐3β‐TFEB
Conclusions: Female mice were more susceptible to the deleterious effects of dAGEs on cognitive function, which might be owing to its regulation on ER β. Trehalose could strongly reverse dAGEs-induced tau phosphorylation by potentiating TFEB nuclear translocation via inhibiting GSK-3β.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 20, 2021 Category: Food Science Authors: Huan ‐Huan Zhou, Lan Luo, Xue‐Di Zhai, Liangkai Chen, Guiping Wang, Li‐Qiang Qin, Zengli Yu, Li‐Li Xin, Zhongxiao Wan Tags: Research Article Source Type: research

Front Cover: N ‐3 PUFA‐Deficiency in Early Life Exhibits Aggravated MPTP‐Induced Neurotoxicity in Old Age while Supplementation with DHA/EPA‐Enriched Phospholipids Exerts a Neuroprotective Effect
Mol. Nutr. Food Res. 2021,65,202100339DOI:10.1002/mnfr.202100339Dietary n-3 PUFA-deficiency in early life throughout pregnancy and lactation exacerbates MPTP-induced neurotoxicity of offspring in old age, which showed poor motor performance, the loss of dopaminergic neurons, mitochondrial dysfunction and neurodevelopment delay. Moreover, DHA- and EPA-enriched phospholipids supplementation in old age recovers brain DHA levels and exerts neuroprotective effects in long-term n-3 PUFA-deficient mice. This is reported by Tian-Tian Zhang and co-workers in article number2100339. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 20, 2021 Category: Food Science Authors: Fang Wu, Dan ‐Dan Wang, Hao‐Hao Shi, Cheng‐Cheng Wang, Chang‐Hu Xue, Yu‐Ming Wang, Tian‐Tian Zhang Tags: Front Cover Source Type: research

Back Cover: Dietary Sterols and Sterol Oxidation Products on Atherosclerosis: An Insight Provided by Liver Proteomic and Lipidomic
Mol. Nutr. Food Res. 2021,65,202100516DOI:10.1002/mnfr.202100516Dietary phytosterols and sterol oxidation products exhibit significant different effects on atherosclerosis, and changes in liver lipid metabolism may provide another insight for their effects. As revealed by lipidomes and proteome in this report, besides cholesterol, phytosterols and sterol oxidation products also greatly affected glycerophospholipids& glycerolipids metabolism and sphingolipids metabolism. This is reported by Xuan Yang, Baiyi Lu, and co-workers in article number2100516. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 20, 2021 Category: Food Science Authors: Mengmeng Wang, Yan Liu, Tian Zhao, Fan Xiao, Xuan Yang, Baiyi Lu Tags: Back Cover Source Type: research

Editorial Board: Mol. Nutr. Food Res. 20'21
(Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 20, 2021 Category: Food Science Tags: Editorial Board Source Type: research

Increasing Post ‐Digestive Solubility of Curcumin is the most Successful Strategy to Improve its Oral Bioavailability: A Randomized Cross‐Over Trial in Healthy Adults and In Vitro Bioaccessibility Experiments
AbstractScope: Different mechanistic approaches to improve the low oral bioavailability of curcumin have been developed, but not yet directly compared in humans.Methods and Results: In a randomized, double-blind, cross-over trial with 12 healthy adults, we compared the 24 h pharmacokinetics of a single dose of 207  mg curcumin from the following formulations: native, liposomes, with turmeric oils, with adjuvants (including piperine), submicron-particles, phytosomes, γ-cyclodextrin complexes and micelles. No free, but only conjugated curcumin was detected in all subjects. Compared to native curcumin, a signi fica...
Source: Molecular Nutrition and Food Research - October 19, 2021 Category: Food Science Authors: Sandra Flory, Nadine Sus, Kathrin Haas, Sina Jehle, Eva Kienh öfer, Reinhard Waehler, Günther Adler, Sascha Venturelli, Jan Frank Tags: Research Article Source Type: research

β‐Carotene Bioavailability and Conversion Efficiency Are Significantly Affected by Sex in Rats
Conclusionsβ-Carotene bioavailability and conversion efficiency to VA are affected by the sex of rats. Results of gene expression suggest a hormetic regulation of VA metabolism in female rats. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 19, 2021 Category: Food Science Authors: Patrick Borel, Romane Troadec, Morgane Damiani, Charlotte Halimi, Marion Nowicki, Philippe Guichard, Marielle Margier, Julien Astier, Michel Grino, Emmanuelle Reboul, Jean ‐François Landrier Tags: Research Article Source Type: research

Resveratrol Improves Follicular Development of PCOS Rats by Regulating the Glycolytic Pathway
ConclusionResveratrol suppressed damage to the ovaries in PCOS rats by restoring glycolytic activity, providing potential targets for the treatment of PCOS.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 19, 2021 Category: Food Science Authors: Aihong Liang, Lan'e Huang, Huiqing Liu, Weiguo He, Xiaocan Lei, Meixiang Li, Suyun Li, Hongxing Liang, Gang Chen, Jinru Tang, Fengyu Chen, Xiting Cao, Yiyao Wang, Xiaobu Shen, Xi Chen Tags: Research Article Source Type: research

Food and Microbiota Metabolites Associate with Cognitive Decline in Older Subjects: A twelve ‐Year Prospective Study
Conclusion: These results provide insight into the early metabolic events that are associated with the later risk to develop cognitive decline within the crosstalk between diet, gut microbiota and the endogenous metabolism, which could help identify potential targets for preventive and therapeutic strategies to preserve cognitive health.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 19, 2021 Category: Food Science Authors: Ra úl González‐Domínguez, Pol Castellano‐Escuder, Francisco Carmona, Sophie Lefèvre‐Arbogast, Dorrain Y. Low, Andrea Du Preez, Silvie R. Ruigrok, Claudine Manach, Mireia Urpi‐Sarda, Aniko Korosi, Paul J. Lucassen, Ludwig Aigner, Me Tags: Research Article Source Type: research

Dietary Linalool is Transferred Into the Milk of Nursing Mothers
Conclusion: Ingestion of a customary curry dish can lead to an alteration of the milk aroma, which might be perceived by the infant during breastfeeding. The current study also demonstrates that the extent of aroma transfer differs between both substances and individuals.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 18, 2021 Category: Food Science Authors: Marcel W. Debong, Katharina N'Diaye, Diana Owsienko, Daniela Sch öberl, Tayyaba Ammar, Roman Lang, Andrea Buettner, Thomas Hofmann, Helene M. Loos Tags: Research Article Source Type: research

Detection of a Hemoglobin Adduct of the Food Contaminant Furfuryl Alcohol in Humans: Levels of N ‐((Furan‐2‐yl)methyl)‐valine in two Epidemiological Studies
ScopeFurfuryl alcohol is a heat-induced food contaminant, classified as possibly carcinogenic to humans. The proximal carcinogen 2-sulfoxymethylfuran leads to adduct formation in DNA and proteins (e.g.,N-((furan-2-yl)methyl)-Val (FFA-Val) in hemoglobin).Methods and resultsWe analyzed human erythrocyte samples from two studies for the presence of FFA-Val: theRisks and Benefits of a Vegan Diet study (RBVD; 72 adults) and the ENVIRonmental influenceON early AGEing birth cohort study (ENVIRONAGE; 100 mother-newborn pairs). In the RBVD study, FFA-Val levels were lower in vegans compared to omnivores (median 13.0  versus 15...
Source: Molecular Nutrition and Food Research - October 15, 2021 Category: Food Science Authors: Bernhard H. Monien, Nick Bergau, Janneke G.F. Hogervorst, Tim S. Nawrot, Iris Trefflich, Cornelia Weikert, Klaus Abraham Tags: Research Article Source Type: research

PBK model ‐based prediction of intestinal microbial and host metabolism of zearalenone and consequences for its estrogenicity
Conclusion: It is concluded that combining kinetic data on liver and intestinal microbial metabolism in a PBK model facilitates a holistic view on the role of the intestinal microbiota in the overall metabolism of the foodborne xenobiotic ZEN and its bioactivation to α-ZEL.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - October 15, 2021 Category: Food Science Authors: Diana M. Mendez ‐Catala, Qianrui Wang, Ivonne M.C.M. Rietjens Tags: Research Article Source Type: research