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High Fat Diet –Wheat Gliadin Interaction and its Implication for Obesity and Celiac Disease Onset: In Vivo Studies
Wheat gluten may play a role for development of life-style related diseases in populations on a high fat diet. Mice feed high fat diet show that wheat gliadin consumption affects glucose and lipid metabolic homeostasis, alters the gut microbiota and the immune cell profile in liver. AbstractThe intestinal immune system plays a crucial role in obesity and insulin resistance. An altered intestinal immunity is associated with changes to the gut microbiota, barrier function, and tolerance to luminal antigens. Lipid metabolism and its unbalance can also contribute to acute and chronic inflammation in different conditions. In ce...
Source: Molecular Nutrition and Food Research - April 18, 2024 Category: Food Science Authors: Yuri Haneishi, Lucia Treppiccione, Francesco Maurano, Diomira Luongo, Junki Miyamoto, Mauro Rossi Tags: Review Source Type: research

Molecular Characterization of the Allergenic Arginine Kinase from the Edible Insect Hermetia illucens (Black Soldier Fly)
ConclusionThe results indicate that the possible allergenicity of AK should be taken in consideration when dealing with novel foods containingH. illucens or its derivatives. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 17, 2024 Category: Food Science Authors: Danila Delfino, Barbara Prandi, Luisa Calcinai, Erminia Ridolo, Luca Dellafiora, Lorenzo Pedroni, Francesca Nicoletta, Davide Cavazzini, Tullia Tedeschi, Claudia Folli Tags: Research Article Source Type: research

Front Cover: Profiling of Metabolites in a Fermented Soy Dietary Supplement Reinforces its Role in the Management of Intestinal Inflammation
Mol. Nutr. Food Res. 2024,68,2300770DOI:10.1002/mnfr.202300770The cover image is based on the Research ArticleProfiling of Metabolites in a Fermented Soy Dietary Supplement Reinforces its Role in the Management of Intestinal Inflammation by Richard Ethier et al.,https://doi.org/10.1002/mnfr.202300770 (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 16, 2024 Category: Food Science Authors: Richard Ethier, Arun Krishnamurthy, Michael Jeffrey, Thomas A. Tompkins Tags: Front Cover Source Type: research

Issue Information: Mol. Nutr. Food Res. 7'24
(Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 16, 2024 Category: Food Science Tags: Issue Information Source Type: research

Assessing and Comparing Potential Allergenicity of Two Partially Hydrolyzed Whey ‐Based Formulas for Infants: A Population‐Based Study in China
ConclusionThe two PHF-Ws have notably high intolerance rates, exceeding 10% among infants with CMA. Therefore, suggesting that PHF-Ws may not be suitable for infants and children with CMA in China. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 12, 2024 Category: Food Science Authors: Lijuan Sun, Shiwen Han, Sufang Duan, Like Mao, Fang Li, Zhenhua Tu, Huilian Che Tags: Research Article Source Type: research

Curry ‐Odorants and Their Metabolites Transfer into Human Milk and Urine
ConclusionThe transfer profiles of odorants into milk and urine differ qualitatively, quantitatively, and in temporal aspects. More substances are transferred into urine and the transfer needs a longer period compared with milk. Phase II metabolites are transferred into urine and milk. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 11, 2024 Category: Food Science Authors: Marcel W. Debong, Ines Homm, Michael Gigl, Roman Lang, Thomas Hofmann, Andrea Buettner, Corinna Dawid, Helene M. Loos Tags: Research Article Source Type: research

Polyphenol Extracts from Ziziphus jujuba Mill. “Junzao” Attenuates Ulcerative Colitis by Inhibiting the NLRP3 and MAPKs Signaling Pathways and Regulating Gut Microbiota Homeostasis in Mice
ConclusionPERJ probably inhibits the development of UC by suppressing the NLRP3 and MAPKs signaling pathways and regulating gut microbiota homeostasis, and can be considered as a potential resource for preventing UC. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 11, 2024 Category: Food Science Authors: Xiaobo Wei, Ni Ma, Wen Yang, Jinhu Tian, Huiyan Liu, Haitian Fang Tags: Research Article Source Type: research

Investigation of Antiproliferative Effects of Combinations of White and Black Garlic Extracts with 5 ‐Fluorouracil (5‐FU) on Caco‐2 Colorectal Adenocarcinoma Cells
In conclusion, aqueous black garlic extract may exhibit pro-oxidant activity despite its high antioxidant capacity. It is worth noting that exposure to heat-treated food and increased sugar content may lead to heightened inflammation and adverse health effects. This study is the first to combine garlic with chemo-preventive drugs like 5-FU in Caco-2 cells. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 11, 2024 Category: Food Science Authors: Derya Ozalp Unal, Tevhide Sel Tags: Research Article Source Type: research

Nutritional Sources and Anticancer Potential of Phenethyl Isothiocyanate: Molecular Mechanisms and Therapeutic Insights
Phenethyl Isothiocyanate (PEITC) exhibits its anticancer potential by modulating key signaling pathways, enforcing cell cycle arrest, promoting apoptosis, and enhancing drug efficacy by overcoming multidrug resistance and influencing drug metabolism enzymes. AbstractPhenethyl isothiocyanate (PEITC), a compound derived from cruciferous vegetables, has garnered attention for its anticancer properties. This review synthesizes existing research on PEITC, focusing on its mechanisms of action in combatting cancer. PEITC has been found to be effective against various cancer types, such as breast, prostate, lung, colon, and pancre...
Source: Molecular Nutrition and Food Research - April 11, 2024 Category: Food Science Authors: Shahira M. Ezzat, Rana M. Merghany, Passent M. Abdel Baki, Nariman Ali Abdelrahim, Sohaila M. Osman, Mohamed A. Salem, Sheila I. Pe ña‐Corona, Hernán Cortés, Lashyn Kiyekbayeva, Gerardo Leyva‐Gómez, Javad Sharifi‐Rad, Daniela Calina Tags: Review Source Type: research

A New Insight into Fatty Acid Binding Protein 4 Mechanisms and Therapeutic Implications in Obesity ‐Associated Diseases: A Mini Review
FABP4 (Fatty acid binding protein4), a lipid-binding protein, plays a key role in fat metabolism and is linked to obesity, diabetes, and cardiovascular diseases. Its inhibition could benefit obesity-related conditions, particularly insulin resistance and diabetes. FABP4's release from adipose tissue influences lipid metabolism and insulin function, correlating with BMI and metabolic syndrome, making it a potential target for therapeutic intervention. AbstractFatty acid binding proteins (FABPs), such as FABP4 (aP2, A-FABP), are essential for cellular lipid regulation, membrane –protein interactions, and the modulation of ...
Source: Molecular Nutrition and Food Research - April 10, 2024 Category: Food Science Authors: Feyza Nur Ba şarır Sivri, Seda Çiftçi Tags: Review Source Type: research

Naringenin Alleviates Radiation ‐Induced Intestinal Injury by Inhibiting TRPV6 in Mice
ConclusionNAR inhibits the apoptosis pathway by downregulating TRPV6 and reducing calcium ion level, thereby alleviating RIII. Therefore, NAR is a promising therapeutic drug for RIII. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 7, 2024 Category: Food Science Authors: Zhi Ling, Zheng Wang, Lin Chen, Jingxian Mao, Dongmei Ma, Xiao Han, Linlin Tian, Qingtian Zhu, Guotao Lu, Xuebing Yan, Yanbing Ding, Weiming Xiao, Yong Chen, Aijun Peng, Xudong Yin Tags: Research Article Source Type: research

Bcat2 ‐Mediated Branched‐Chain Amino Acid Catabolism Is Linked to the Aggravated Inflammation in Obese with Psoriasis Mice
Conclusion: HFD-induced obesity significantly amplifies IL-17 signaling and exacerbates psoriasis, with a potential role played by Bcat2-mediated BCAAs metabolism. The study suggests that BCAA catabolism and PPAR γ-STAT3 exacerbate inflammation in psoriasis with obesity. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 6, 2024 Category: Food Science Authors: Yazhuo Wang, Ning Zhao, Yujiao Meng, Jia Chen, Cong Qi, Xueqing Hu, Haoyue Zhu, Danyang Yang, Xiawei Zhang, Huike Ma, Jingxia Zhao, Tingting Di, Ping Li, Yan Wang Tags: Research Article Source Type: research

Modifying Effects of Genetic Variations on the Association Between Dietary Isothiocyanate Exposure and Non ‐muscle Invasive Bladder Cancer Prognosis in the Be‐Well Study
ConclusionDespite that genetic variations in ITC-metabolizing/functioning genes may modify the effect of dietary ITCs on NMIBC prognosis, dietary recommendation of CV consumption may help improve NMIBC survivorship. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 6, 2024 Category: Food Science Authors: Zinian Wang, Marilyn L. Kwan, Reina Haque, Prashant K. Singh, Maciej Goniewicz, Rachel Pratt, Valerie S. Lee, Janise M. Roh, Isaac J. Ergas, Kimberly L. Cannavale, Ronald K. Loo, David S. Aaronson, Charles P. Quesenberry, Yuesheng Zhang, Chr Tags: Research Article Source Type: research

Issue Information: Mol. Nutr. Food Res. 6'24
(Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 3, 2024 Category: Food Science Tags: Issue Information Source Type: research

Dietary Supplementation with Nervonic Acid Ameliorates Cerebral Ischemia ‐Reperfusion Injury by Modulating of Gut Microbiota Composition‐Fecal Metabolites Interaction
ConclusionThese comprehensive findings highlight the potential of incorporating NA as a functional component in dietary interventions aimed at targeting cerebral IR injury. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 3, 2024 Category: Food Science Authors: Hui Zhou, Ziyi Chen, Jingbin Li, Rongjin Wang, Hongshi Bu, Chengjiang Ruan Tags: Research Article Source Type: research