Comparative analysis of the antimicrobial resistance and virulence traits in ESBL-producing-Klebsiella pneumoniae ST307 strains colonizing the gastrointestinal tract and causing a fatal bloodstream infection in a leukemia patient
Infect Genet Evol. 2024 Apr 21:105598. doi: 10.1016/j.meegid.2024.105598. Online ahead of print.ABSTRACTKlebsiella pneumoniae is an opportunistic pathogen that can colonize the gastrointestinal tract (GIT) of humans. The mechanisms underlying the successful translocation of this pathogen to cause extra-intestinal infections remain unknown, although virulence and antimicrobial resistance traits likely play significant roles in the establishment of infections. We investigated K. pneumoniae strains isolated from GIT colonization (strains Kp_FZcol-1, Kp_FZcol-2 and Kp_FZcro-1) and from a fatal bloodstream infection (strain Kp_...
Source: Infection, Genetics and Evolution - April 23, 2024 Category: Genetics & Stem Cells Authors: Luana Boff Humberl ânia de Sousa Duarte Gabriela Bergiante Kraychete Gabriel Taddeucci-Rocha Bianca Diniz Oliveira Rodolpho Mattos Albano Ana Paula D'Alincourt Carvalho-Assef Silvana Vargas Superti Ianick Souto Martins Renata Cristina Pic ão Source Type: research
Comparative analysis of the antimicrobial resistance and virulence traits in ESBL-producing-Klebsiella pneumoniae ST307 strains colonizing the gastrointestinal tract and causing a fatal bloodstream infection in a leukemia patient
Infect Genet Evol. 2024 Apr 21:105598. doi: 10.1016/j.meegid.2024.105598. Online ahead of print.ABSTRACTKlebsiella pneumoniae is an opportunistic pathogen that can colonize the gastrointestinal tract (GIT) of humans. The mechanisms underlying the successful translocation of this pathogen to cause extra-intestinal infections remain unknown, although virulence and antimicrobial resistance traits likely play significant roles in the establishment of infections. We investigated K. pneumoniae strains isolated from GIT colonization (strains Kp_FZcol-1, Kp_FZcol-2 and Kp_FZcro-1) and from a fatal bloodstream infection (strain Kp_...
Source: Infection, Genetics and Evolution - April 23, 2024 Category: Genetics & Stem Cells Authors: Luana Boff Humberl ânia de Sousa Duarte Gabriela Bergiante Kraychete Gabriel Taddeucci-Rocha Bianca Diniz Oliveira Rodolpho Mattos Albano Ana Paula D'Alincourt Carvalho-Assef Silvana Vargas Superti Ianick Souto Martins Renata Cristina Pic ão Source Type: research
KPC-2-producing Enterobacterales from ready-to-eat food to hospitalized patients
Infect Genet Evol. 2024 Apr 19:105596. doi: 10.1016/j.meegid.2024.105596. Online ahead of print.ABSTRACTFoodstuffs are a well-documented source of multidrug-resistant bacteria, and hospitalized patients are usually susceptible to hospital infections owing to their immune status. Therefore, this study aimed to investigate the presence of beta-lactamase-producing Enterobacterales in ready-to-eat foods consumed by hospitalized patients. For this purpose, 51 vegetable and meat samples were collected over 2 months and analyzed. Enterobacterales isolates were identified and subjected to antimicrobial susceptibility testing, foll...
Source: Infection, Genetics and Evolution - April 21, 2024 Category: Genetics & Stem Cells Authors: Bianca Lara Ven âncio de Godoy Marlon do Valle Barroso Yasmin Fontoura de Azeredo Louren ção Let ícia Kellen de Andrade Vit ória Gabriela Tosta Rodrigues Caroline Atu í Ana Caroline do Valle Ta ís Paulino Ferreira Mara Corr êa Lelles Nogueira Tiag Source Type: research
Novel clades of tick-borne pathogenic nairoviruses in Europe
Infect Genet Evol. 2024 Apr 16;121:105593. doi: 10.1016/j.meegid.2024.105593. Online ahead of print.ABSTRACTMembers of the Orthonairovirus genus (family Nairoviridae) include many tick-borne viruses of significant human and animal health impact, with several recently-documented pathogenic viruses lacking sufficient epidemiological information. We screened 215 adult ticks of seven species collected in Bulgaria, Georgia, Latvia and Poland for orthonairoviruses, followed by nanopore sequencing (NS) for genome characterization. Initial generic amplification revealed Sulina virus (SULV, Orthonairovirus sulinaense), for which an...
Source: Infection, Genetics and Evolution - April 18, 2024 Category: Genetics & Stem Cells Authors: Koray Ergunay Brian P Bourke Drew D Reinbold-Wasson Laura Caicedo-Quiroga Nataliya Vaydayko Giorgi Kirkitadze Tamar Chunashvili Cynthia L Tucker Yvonne-Marie Linton Source Type: research
Critically-ill COVID-19 susceptibility gene CCR3 shows natural selection in sub-Saharan Africans
Infect Genet Evol. 2024 Apr 16:105594. doi: 10.1016/j.meegid.2024.105594. Online ahead of print.ABSTRACTThe prevalence of COVID-19 critical illness varies across ethnicities, with recent studies suggesting that genetic factors may contribute to this variation. The aim of this study was to investigate natural selection signals of genes associated with critically-ill COVID-19 in sub-Saharan Africans. Severe COVID-19 SNPs were obtained from the HGI website. Selection signals were assessed in 661 sub-Sahara Africans from 1000 Genomes Project using integrated haplotype score (iHS), cross-population extended haplotype homozygosi...
Source: Infection, Genetics and Evolution - April 18, 2024 Category: Genetics & Stem Cells Authors: Zewen Sun Lin Pan Aowen Tian Peng Chen Source Type: research
Emerging threats of high biofilm formation and antibiotic resistance in clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates from Pakistan
CONCLUSIONS: Clinical MRSA strains exhibit a substantial potential for biofilm formation, contributing to a resistant phenotype. Routine antibiotic testing in clinical settings that overlook the biofilm aspect may lead to the failure of empiric antibiotic therapy.PMID:38614413 | DOI:10.1016/j.meegid.2024.105592 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - April 13, 2024 Category: Genetics & Stem Cells Authors: Asad Ali Saba Riaz Source Type: research
Emerging threats of high biofilm formation and antibiotic resistance in clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates from Pakistan
CONCLUSIONS: Clinical MRSA strains exhibit a substantial potential for biofilm formation, contributing to a resistant phenotype. Routine antibiotic testing in clinical settings that overlook the biofilm aspect may lead to the failure of empiric antibiotic therapy.PMID:38614413 | DOI:10.1016/j.meegid.2024.105592 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - April 13, 2024 Category: Genetics & Stem Cells Authors: Asad Ali Saba Riaz Source Type: research
Emerging threats of high biofilm formation and antibiotic resistance in clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates from Pakistan
CONCLUSIONS: Clinical MRSA strains exhibit a substantial potential for biofilm formation, contributing to a resistant phenotype. Routine antibiotic testing in clinical settings that overlook the biofilm aspect may lead to the failure of empiric antibiotic therapy.PMID:38614413 | DOI:10.1016/j.meegid.2024.105592 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - April 13, 2024 Category: Genetics & Stem Cells Authors: Asad Ali Saba Riaz Source Type: research
Emerging threats of high biofilm formation and antibiotic resistance in clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates from Pakistan
CONCLUSIONS: Clinical MRSA strains exhibit a substantial potential for biofilm formation, contributing to a resistant phenotype. Routine antibiotic testing in clinical settings that overlook the biofilm aspect may lead to the failure of empiric antibiotic therapy.PMID:38614413 | DOI:10.1016/j.meegid.2024.105592 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - April 13, 2024 Category: Genetics & Stem Cells Authors: Asad Ali Saba Riaz Source Type: research
A sophisticated virulence repertoire and colistin resistance of Citrobacter freundii ST150 from a patient with sepsis admitted to ICU in a tertiary care hospital in Uganda, East Africa: Insight from genomic and molecular docking analyses
Infect Genet Evol. 2024 Apr 9:105591. doi: 10.1016/j.meegid.2024.105591. Online ahead of print.ABSTRACTSepsis and multidrug resistance comprise a complex of factors attributable to mortality among intensive care unit (ICU) patients globally. Pathogens implicated in sepsis are diverse, and their virulence and drug resistance remain elusive. From a tertiary care hospital ICU in Uganda, we isolated a Citrobacter freundii strain RSM030 from a patient with sepsis and phenotypically tested it against a panel of 16 antibiotics including imipenem levofloxacin, cotrimoxazole and colistin, among others. We sequenced the organism's g...
Source: Infection, Genetics and Evolution - April 11, 2024 Category: Genetics & Stem Cells Authors: Reuben S Maghembe Maximilian A K Magulye Emmanuel Eilu Simon Sekyanzi Abdalah Makaranga Savannah Mwesigwa Eric Katagirya Source Type: research
A sophisticated virulence repertoire and colistin resistance of Citrobacter freundii ST150 from a patient with sepsis admitted to ICU in a tertiary care hospital in Uganda, East Africa: Insight from genomic and molecular docking analyses
Infect Genet Evol. 2024 Apr 9:105591. doi: 10.1016/j.meegid.2024.105591. Online ahead of print.ABSTRACTSepsis and multidrug resistance comprise a complex of factors attributable to mortality among intensive care unit (ICU) patients globally. Pathogens implicated in sepsis are diverse, and their virulence and drug resistance remain elusive. From a tertiary care hospital ICU in Uganda, we isolated a Citrobacter freundii strain RSM030 from a patient with sepsis and phenotypically tested it against a panel of 16 antibiotics including imipenem levofloxacin, cotrimoxazole and colistin, among others. We sequenced the organism's g...
Source: Infection, Genetics and Evolution - April 11, 2024 Category: Genetics & Stem Cells Authors: Reuben S Maghembe Maximilian A K Magulye Emmanuel Eilu Simon Sekyanzi Abdalah Makaranga Savannah Mwesigwa Eric Katagirya Source Type: research
Relative frequency of genomic mutations in SARS-CoV-2 recovered from southern Brazilian cases of COVID-19 through the Gamma, Delta and Omicron waves
In conclusion, we emphasize that genomic surveillance can be a useful tool to assess how mutations play a key role in virus adaptation, and its process of susceptibility to new hosts showing the possible signs of viral evolution.PMID:38574833 | DOI:10.1016/j.meegid.2024.105590 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - April 4, 2024 Category: Genetics & Stem Cells Authors: Micheli Filippi Meriane Demoliner Juliana Schons Gularte Vyctoria Malayhka de Abreu Goes Pereira Mariana Soares da Silva Viviane Girardi Alana Witt Hansen Fernando Rosado Spilki Source Type: research
Relative frequency of genomic mutations in SARS-CoV-2 recovered from southern Brazilian cases of COVID-19 through the Gamma, Delta and Omicron waves
In conclusion, we emphasize that genomic surveillance can be a useful tool to assess how mutations play a key role in virus adaptation, and its process of susceptibility to new hosts showing the possible signs of viral evolution.PMID:38574833 | DOI:10.1016/j.meegid.2024.105590 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - April 4, 2024 Category: Genetics & Stem Cells Authors: Micheli Filippi Meriane Demoliner Juliana Schons Gularte Vyctoria Malayhka de Abreu Goes Pereira Mariana Soares da Silva Viviane Girardi Alana Witt Hansen Fernando Rosado Spilki Source Type: research
Relative frequency of genomic mutations in SARS-CoV-2 recovered from southern Brazilian cases of COVID-19 through the Gamma, Delta and Omicron waves
In conclusion, we emphasize that genomic surveillance can be a useful tool to assess how mutations play a key role in virus adaptation, and its process of susceptibility to new hosts showing the possible signs of viral evolution.PMID:38574833 | DOI:10.1016/j.meegid.2024.105590 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - April 4, 2024 Category: Genetics & Stem Cells Authors: Micheli Filippi Meriane Demoliner Juliana Schons Gularte Vyctoria Malayhka de Abreu Goes Pereira Mariana Soares da Silva Viviane Girardi Alana Witt Hansen Fernando Rosado Spilki Source Type: research
Relative frequency of genomic mutations in SARS-CoV-2 recovered from southern Brazilian cases of COVID-19 through the Gamma, Delta and Omicron waves
In conclusion, we emphasize that genomic surveillance can be a useful tool to assess how mutations play a key role in virus adaptation, and its process of susceptibility to new hosts showing the possible signs of viral evolution.PMID:38574833 | DOI:10.1016/j.meegid.2024.105590 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - April 4, 2024 Category: Genetics & Stem Cells Authors: Micheli Filippi Meriane Demoliner Juliana Schons Gularte Vyctoria Malayhka de Abreu Goes Pereira Mariana Soares da Silva Viviane Girardi Alana Witt Hansen Fernando Rosado Spilki Source Type: research
