Analyzing the COVID-19 vaccination behavior based on epidemic model with awareness-information
CONCLUSIONS: The information-driven vaccination is an effective way to curb the COVID-19 spreading. Besides, to solve vaccine hesitancy and free-ride, the government needs to disseminate accurate information about vaccines safety to alleviate public concerns, and provide the widespread public educational campaigns and communication to guide individuals to act in group interests rather than self-interest and reduce the temptation to free-riding, which often results from individuals who are inadequately informed about vaccines and thus blindly imitate free-riding behavior.PMID:35066164 | DOI:10.1016/j.meegid.2022.105218 (Sou...
Source: Infection, Genetics and Evolution - January 23, 2022 Category: Genetics & Stem Cells Authors: Chao Zuo Fenping Zhu Zeyang Meng Yuting Ling Yuzhi Zheng Xueke Zhao Source Type: research

The OH system: A panorama view of the PPV-host interaction
Infect Genet Evol. 2022 Jan 20:105220. doi: 10.1016/j.meegid.2022.105220. Online ahead of print.ABSTRACTPoxviruses are a family of specialized cytoplasm-parasitic DNA viruses that replicate and assembly in virus factory. In Parapoxvirus (PPV) genus, with the orf virus (ORFV) as a representative species of this genus, their behaviors are significantly different from that of Orthopoxvirus, and the plots of viral practical solutions for evading host immunity are intricate and fascinating, particularly to anti-host and host's antiviral mechanisms. In order to protect the virus factory from immune elimination caused by infectio...
Source: Infection, Genetics and Evolution - January 23, 2022 Category: Genetics & Stem Cells Authors: Yongzhong Yu Zhengxing Lian Yudong Cui Source Type: research

Molecular identification of Leishmania RNA virus in cutaneous leishmaniasis patients and rodent reservoirs in Isfahan province, Iran
Infect Genet Evol. 2022 Jan 20:105222. doi: 10.1016/j.meegid.2022.105222. Online ahead of print.ABSTRACTLeishmania RNA virus (LRV) is a double-strand RNA virus that was first detected in members of the Leishmania viannia in the New World. The present study aimed to investigate the presence of LRV in the Leishmania species isolated from cutaneous leishmaniasis (CL) patients and rodents as reservoirs in Isfahan province an old zoonotic CL focus, center of Iran. Totally, 85 samples were collected from CL patients (n = 80) and rodent reservoirs (n = 5) from different regions of Isfahan province. Species identification was dete...
Source: Infection, Genetics and Evolution - January 23, 2022 Category: Genetics & Stem Cells Authors: Mojgan Farrokhi-Karibozorg Zahra Ghayour-Najafabadi Seyed Hossein Hejazi Angila Ataei-Pirkooh Mehdi Mohebali Parvin Teimouri Homa Hajjaran Source Type: research

Prevalence and genotypes/subtypes of Enterocytozoon bieneusi and Blastocystis sp. in different breeds of cattle in Jiangxi Province, southeastern China
Infect Genet Evol. 2022 Jan 20:105216. doi: 10.1016/j.meegid.2022.105216. Online ahead of print.ABSTRACTEnterocytozoon bieneusi and Blastocystis sp. are common zoonotic pathogens that parasitize in the small intestine of humans and animals, posing a threat to public health. However, little information is available on the prevalence and genotypes/subtypes of E. bieneusi and Blastocystis sp. in cattle in Jiangxi Province, southeastern China. In the present study, 556 fecal samples of cattle were collected from Nanchang city, Gao'an city, Xinyu city, and Ji'an city in Jiangxi Province. All samples were examined for the presen...
Source: Infection, Genetics and Evolution - January 23, 2022 Category: Genetics & Stem Cells Authors: Sen Li Ping Wang Xing-Quan Zhu Yang Zou Xiao-Qing Chen Source Type: research

Cassava Brown Streak Viruses express second 6-kilodalton (6K2) protein with varied polarity and three dimensional (3D) structures: Basis for trait discrepancy between the virus species
Infect Genet Evol. 2022 Jan 20:105219. doi: 10.1016/j.meegid.2022.105219. Online ahead of print.ABSTRACTCassava Brown Streak Virus (CBSV) and Ugandan Cassava Brown Streak Virus (UCBSV) are the two among six virus species speculated to cause the most catastrophic Brown Streak Disease of Cassava (CBSD) in Africa and Asia. For unknown reasons, Cassava Brown Streak Virus (CBSV) is hard to breed resistance for compared to Ugandan Cassava Brown Streak Virus (UCBSV) species. This exemplified by incidences of CBSV species rather than UCBSV species in elite breeding line, KBH 2006/0026 at Bagamoyo, Tanzania. It is not yet understoo...
Source: Infection, Genetics and Evolution - January 23, 2022 Category: Genetics & Stem Cells Authors: Herieth Rhodes Mero Sylvester Leonard Lyantagaye Erik Bongcam Rudloff Source Type: research

Analyzing the COVID-19 vaccination behavior based on epidemic model with awareness-information
CONCLUSIONS: The information-driven vaccination is an effective way to curb the COVID-19 spreading. Besides, to solve vaccine hesitancy and free-ride, the government needs to disseminate accurate information about vaccines safety to alleviate public concerns, and provide the widespread public educational campaigns and communication to guide individuals to act in group interests rather than self-interest and reduce the temptation to free-riding, which often results from individuals who are inadequately informed about vaccines and thus blindly imitate free-riding behavior.PMID:35066164 | DOI:10.1016/j.meegid.2022.105218 (Sou...
Source: Infection, Genetics and Evolution - January 23, 2022 Category: Genetics & Stem Cells Authors: Chao Zuo Fenping Zhu Zeyang Meng Yuting Ling Yuzhi Zheng Xueke Zhao Source Type: research

The OH system: A panorama view of the PPV-host interaction
Infect Genet Evol. 2022 Jan 20:105220. doi: 10.1016/j.meegid.2022.105220. Online ahead of print.ABSTRACTPoxviruses are a family of specialized cytoplasm-parasitic DNA viruses that replicate and assembly in virus factory. In Parapoxvirus (PPV) genus, with the orf virus (ORFV) as a representative species of this genus, their behaviors are significantly different from that of Orthopoxvirus, and the plots of viral practical solutions for evading host immunity are intricate and fascinating, particularly to anti-host and host's antiviral mechanisms. In order to protect the virus factory from immune elimination caused by infectio...
Source: Infection, Genetics and Evolution - January 23, 2022 Category: Genetics & Stem Cells Authors: Yongzhong Yu Zhengxing Lian Yudong Cui Source Type: research

Molecular identification of Leishmania RNA virus in cutaneous leishmaniasis patients and rodent reservoirs in Isfahan province, Iran
Infect Genet Evol. 2022 Jan 20:105222. doi: 10.1016/j.meegid.2022.105222. Online ahead of print.ABSTRACTLeishmania RNA virus (LRV) is a double-strand RNA virus that was first detected in members of the Leishmania viannia in the New World. The present study aimed to investigate the presence of LRV in the Leishmania species isolated from cutaneous leishmaniasis (CL) patients and rodents as reservoirs in Isfahan province an old zoonotic CL focus, center of Iran. Totally, 85 samples were collected from CL patients (n = 80) and rodent reservoirs (n = 5) from different regions of Isfahan province. Species identification was dete...
Source: Infection, Genetics and Evolution - January 23, 2022 Category: Genetics & Stem Cells Authors: Mojgan Farrokhi-Karibozorg Zahra Ghayour-Najafabadi Seyed Hossein Hejazi Angila Ataei-Pirkooh Mehdi Mohebali Parvin Teimouri Homa Hajjaran Source Type: research

Prevalence and genotypes/subtypes of Enterocytozoon bieneusi and Blastocystis sp. in different breeds of cattle in Jiangxi Province, southeastern China
Infect Genet Evol. 2022 Jan 20:105216. doi: 10.1016/j.meegid.2022.105216. Online ahead of print.ABSTRACTEnterocytozoon bieneusi and Blastocystis sp. are common zoonotic pathogens that parasitize in the small intestine of humans and animals, posing a threat to public health. However, little information is available on the prevalence and genotypes/subtypes of E. bieneusi and Blastocystis sp. in cattle in Jiangxi Province, southeastern China. In the present study, 556 fecal samples of cattle were collected from Nanchang city, Gao'an city, Xinyu city, and Ji'an city in Jiangxi Province. All samples were examined for the presen...
Source: Infection, Genetics and Evolution - January 23, 2022 Category: Genetics & Stem Cells Authors: Sen Li Ping Wang Xing-Quan Zhu Yang Zou Xiao-Qing Chen Source Type: research

Cassava Brown Streak Viruses express second 6-kilodalton (6K2) protein with varied polarity and three dimensional (3D) structures: Basis for trait discrepancy between the virus species
Infect Genet Evol. 2022 Jan 20:105219. doi: 10.1016/j.meegid.2022.105219. Online ahead of print.ABSTRACTCassava Brown Streak Virus (CBSV) and Ugandan Cassava Brown Streak Virus (UCBSV) are the two among six virus species speculated to cause the most catastrophic Brown Streak Disease of Cassava (CBSD) in Africa and Asia. For unknown reasons, Cassava Brown Streak Virus (CBSV) is hard to breed resistance for compared to Ugandan Cassava Brown Streak Virus (UCBSV) species. This exemplified by incidences of CBSV species rather than UCBSV species in elite breeding line, KBH 2006/0026 at Bagamoyo, Tanzania. It is not yet understoo...
Source: Infection, Genetics and Evolution - January 23, 2022 Category: Genetics & Stem Cells Authors: Herieth Rhodes Mero Sylvester Leonard Lyantagaye Erik Bongcam Rudloff Source Type: research

Is C ôte D'Ivoire a new high hybridization zone for the two major malaria vectors, Anopheles coluzzii and An. gambiae (Diptera, Culicidae)?
Infect Genet Evol. 2022 Jan 18:105215. doi: 10.1016/j.meegid.2022.105215. Online ahead of print.ABSTRACTAnopheles gambiae and An. coluzzii are very closely related and recently differentiated species representing the main malaria vectors in the Afrotropical region and responsible of up to>3 infective bites/person/night in Côte D'Ivoire, where prevention and control has stagnated in recent years. The aim of the present study was to genetically and ecologically characterize An. gambiae and An. coluzzii populations from two villages of Côte D'Ivoire, lying in the coastal forest belt and 250 km inland in the Gui...
Source: Infection, Genetics and Evolution - January 22, 2022 Category: Genetics & Stem Cells Authors: Beniamino Caputo Naminata Tondossoma Chiara Virgillito Verena Pichler Paola Serini Maria Calzetta Mattia Manica Zanakoungo Ibrahim Coulibaly Ibrahima Dia Maurice Adja Akr é Andre Offianan Alessandra Della Torre Source Type: research

Season, weight, and age, but not transmissible cancer, affect tick loads in the endangered Tasmanian devil
Infect Genet Evol. 2022 Jan 19:105221. doi: 10.1016/j.meegid.2022.105221. Online ahead of print.ABSTRACTThe Tasmanian devil (Sarcophilus harrisii) is a carnivorous marsupial threatened by a transmissible cancer, devil facial tumour disease (DFTD). While we have a good understanding of the effect of the transmissible cancer on its host, little information is available about its potential interactions with ectoparasites. With this study, we aimed to determine the factors driving tick loads in a DFTD affected Tasmanian devil population, using long-term mark-recapture data. We investigated the effect of a range of life history...
Source: Infection, Genetics and Evolution - January 22, 2022 Category: Genetics & Stem Cells Authors: Sophia Belkhir Rodrigo Hamede Fr édéric Thomas Beata Ujvari Antoine M Dujon Source Type: research

A review of the molecular epidemiology of Cryptosporidium spp. and Giardia duodenalis in the Middle East and North Africa (MENA) region
Infect Genet Evol. 2022 Jan 19:105212. doi: 10.1016/j.meegid.2022.105212. Online ahead of print.ABSTRACTCryptosporidium spp. and Giardia duodenalis are important protozoan parasites which are associated with diarrheal diseases in humans and animals worldwide. Relatively little is known about the molecular epidemiology of Cryptosporidium spp. and Giardia duodenalis in the Middle East Countries and North Africa (MENA region). Therefore, this review aimed to inspect published genotyping and subtyping studies on Cryptosporidium spp. and Giardia duodenalis in the MENA region. These studies indicate that both anthroponotic and z...
Source: Infection, Genetics and Evolution - January 22, 2022 Category: Genetics & Stem Cells Authors: Nawal Hijjawi Alizera Zahedi Mohammed Al-Falah Una Ryan Source Type: research

Threat, challenges, and preparedness for future pandemics: A descriptive review of phylogenetic analysis based predictions
In this study, the evolutionary history of the pathogens was identified by carrying out phylogenetic analysis. The percentage similarity between different infectious diseases is critically analysed for the identification of their correlation using online sequence matcher tools. The Baltimore classification system was used for finding the genomic nature of the viruses. It was observed that most of the infectious pathogens rise from their animal hosts with some mutations in their genome composition. The phylogenetic tree shows that the single-stranded RNA diseases have a common origin and many of them are having high similar...
Source: Infection, Genetics and Evolution - January 22, 2022 Category: Genetics & Stem Cells Authors: Amanpreet Behl Ashrit Nair Sanika Mohagaonkar Pooja Yadav Kirtida Gambhir Nishant Tyagi Rakesh Kumar Sharma Bhupendra Singh Butola Navneet Sharma Source Type: research

Is C ôte D'Ivoire a new high hybridization zone for the two major malaria vectors, Anopheles coluzzii and An. gambiae (Diptera, Culicidae)?
Infect Genet Evol. 2022 Jan 18:105215. doi: 10.1016/j.meegid.2022.105215. Online ahead of print.ABSTRACTAnopheles gambiae and An. coluzzii are very closely related and recently differentiated species representing the main malaria vectors in the Afrotropical region and responsible of up to>3 infective bites/person/night in Côte D'Ivoire, where prevention and control has stagnated in recent years. The aim of the present study was to genetically and ecologically characterize An. gambiae and An. coluzzii populations from two villages of Côte D'Ivoire, lying in the coastal forest belt and 250 km inland in the Gui...
Source: Infection, Genetics and Evolution - January 22, 2022 Category: Genetics & Stem Cells Authors: Beniamino Caputo Naminata Tondossoma Chiara Virgillito Verena Pichler Paola Serini Maria Calzetta Mattia Manica Zanakoungo Ibrahim Coulibaly Ibrahima Dia Maurice Adja Akr é Andre Offianan Alessandra Della Torre Source Type: research

fIdentification of a novel norovirus species in fox
This study identified a new GVII norovirus from wild foxes in China. These findings enrich our understanding of the diversity of NoVs and provide further evidence regarding the genetic heterogeneity of NoVs in carnivores.PMID:35051652 | DOI:10.1016/j.meegid.2022.105214 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - January 20, 2022 Category: Genetics & Stem Cells Authors: Jindong Wang Lili Li Yalong Xu Tongyao Mao Yalin Ma Xiaoman Sun Xiafei Liu Yuanzhi Wang Zhao-Jun Duan Source Type: research

Molecular and pathological screening of canine distemper virus in Asiatic tigers, lions, leopards, snow leopards, clouded leopards, leopard cats, jungle cats, civet cats, fishing cat, and jaguar of different states, India
Infect Genet Evol. 2022 Jan 17:105211. doi: 10.1016/j.meegid.2022.105211. Online ahead of print.ABSTRACTThe present investigation was conducted to rule out canine distemper (CD) diseases in Indian wild felids (Asiatic tigers, lions, leopards, snow leopards, clouded leopards, leopard cats, jungle cats, civet cats, fishing cat, and jaguar). The collected samples were screened for CD virus (CDV) by histopathology (HP), immunohistochemistry (IHC) and reverse transcriptase-polymerase chain reaction (RT-PCR) targeting H gene and N gene. The HP and IHC of suspected samples portrayed that 22 [11 leopards, 6 lions, 3 tigers, 1 snow...
Source: Infection, Genetics and Evolution - January 20, 2022 Category: Genetics & Stem Cells Authors: Rahul Ganpatrao Kadam M Karikalan Chandra Mohan Rajat Varshney Rahul Singh Zahoor Ahemad War Abhijit M Pawde Mayukh Ghosh V Beena K P Singh A K Sharma Source Type: research

fIdentification of a novel norovirus species in fox
This study identified a new GVII norovirus from wild foxes in China. These findings enrich our understanding of the diversity of NoVs and provide further evidence regarding the genetic heterogeneity of NoVs in carnivores.PMID:35051652 | DOI:10.1016/j.meegid.2022.105214 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - January 20, 2022 Category: Genetics & Stem Cells Authors: Jindong Wang Lili Li Yalong Xu Tongyao Mao Yalin Ma Xiaoman Sun Xiafei Liu Yuanzhi Wang Zhao-Jun Duan Source Type: research

Molecular and pathological screening of canine distemper virus in Asiatic tigers, lions, leopards, snow leopards, clouded leopards, leopard cats, jungle cats, civet cats, fishing cat, and jaguar of different states, India
Infect Genet Evol. 2022 Jan 17:105211. doi: 10.1016/j.meegid.2022.105211. Online ahead of print.ABSTRACTThe present investigation was conducted to rule out canine distemper (CD) diseases in Indian wild felids (Asiatic tigers, lions, leopards, snow leopards, clouded leopards, leopard cats, jungle cats, civet cats, fishing cat, and jaguar). The collected samples were screened for CD virus (CDV) by histopathology (HP), immunohistochemistry (IHC) and reverse transcriptase-polymerase chain reaction (RT-PCR) targeting H gene and N gene. The HP and IHC of suspected samples portrayed that 22 [11 leopards, 6 lions, 3 tigers, 1 snow...
Source: Infection, Genetics and Evolution - January 20, 2022 Category: Genetics & Stem Cells Authors: Rahul Ganpatrao Kadam M Karikalan Chandra Mohan Rajat Varshney Rahul Singh Zahoor Ahemad War Abhijit M Pawde Mayukh Ghosh V Beena K P Singh A K Sharma Source Type: research

TSS-seq of Toxoplasma gondii sporozoites revealed a novel motif in stage-specific promoters
In this study, we obtained TSS of Sz using an oligo-capping method and RNA-seq analysis. We identified 1,043,503 TSS in the Sz transcriptome. These defined 38,973 TSS clusters, of which, 11,925 were expressed in Sz and 1535 TSS differentially expressed in Sz. Based on these data, we defined promoter regions and novel sporozoite stage-specific motifs using MEME. TGTANNTACA was distributed around -55 to -75 regions from each TSS. Interestingly, the same motif was reported in another apicomplexan, Plasmodium berghei, as a cis-element of female-specific gametocyte genes, implying the presence of common regulatory machinery. Fu...
Source: Infection, Genetics and Evolution - January 18, 2022 Category: Genetics & Stem Cells Authors: Taishi Kidaka Tatsuki Sugi Kyoko Hayashida Yutaka Suzuki Xuenan Xuan Jitender P Dubey Junya Yamagishi Source Type: research

TSS-seq of Toxoplasma gondii sporozoites revealed a novel motif in stage-specific promoters
In this study, we obtained TSS of Sz using an oligo-capping method and RNA-seq analysis. We identified 1,043,503 TSS in the Sz transcriptome. These defined 38,973 TSS clusters, of which, 11,925 were expressed in Sz and 1535 TSS differentially expressed in Sz. Based on these data, we defined promoter regions and novel sporozoite stage-specific motifs using MEME. TGTANNTACA was distributed around -55 to -75 regions from each TSS. Interestingly, the same motif was reported in another apicomplexan, Plasmodium berghei, as a cis-element of female-specific gametocyte genes, implying the presence of common regulatory machinery. Fu...
Source: Infection, Genetics and Evolution - January 18, 2022 Category: Genetics & Stem Cells Authors: Taishi Kidaka Tatsuki Sugi Kyoko Hayashida Yutaka Suzuki Xuenan Xuan Jitender P Dubey Junya Yamagishi Source Type: research

Emerging role of γδ T cells in protozoan infection and their potential clinical application
Infect Genet Evol. 2022 Jan 11:105210. doi: 10.1016/j.meegid.2022.105210. Online ahead of print.ABSTRACTγδ T cells are thymus derived heterogeneous and unconventional T- lymphocyte expressing TCR γ (V γ9) and TCRδ (Vδ2) chain and play an important role in connecting innate and adaptive armaments of immune response. These cells can recognize wide ranges of antigens even without involvement of major histocompatibility complex and exert their biological functions by cytotoxicity or activating various types of immune cells. In recent past; γδ T cells have emerged as an important ...
Source: Infection, Genetics and Evolution - January 15, 2022 Category: Genetics & Stem Cells Authors: Awnish Kumar Bhawana Singh Rahul Tiwari Vishal Kumar Singh Siddharth Sankar Singh Shyam Sundar Rajiv Kumar Source Type: research

Molecular epidemiology of respiratory syncytial virus in hospitalised children in Heidelberg, Southern Germany, 2014-2017
CONCLUSION: Analysis of the molecular epidemiology of RSV from different seasons revealed the cocirculation and diversification of RSV genotypes ON1 and BAIX.PMID:35032683 | DOI:10.1016/j.meegid.2022.105209 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - January 15, 2022 Category: Genetics & Stem Cells Authors: J Tabatabai C M Ihling R M Rehbein S V Schnee J Hoos J Pfeil J Grulich-Henn P Schnitzler Source Type: research

Emerging role of γδ T cells in protozoan infection and their potential clinical application
Infect Genet Evol. 2022 Jan 11:105210. doi: 10.1016/j.meegid.2022.105210. Online ahead of print.ABSTRACTγδ T cells are thymus derived heterogeneous and unconventional T- lymphocyte expressing TCR γ (V γ9) and TCRδ (Vδ2) chain and play an important role in connecting innate and adaptive armaments of immune response. These cells can recognize wide ranges of antigens even without involvement of major histocompatibility complex and exert their biological functions by cytotoxicity or activating various types of immune cells. In recent past; γδ T cells have emerged as an important ...
Source: Infection, Genetics and Evolution - January 15, 2022 Category: Genetics & Stem Cells Authors: Awnish Kumar Bhawana Singh Rahul Tiwari Vishal Kumar Singh Siddharth Sankar Singh Shyam Sundar Rajiv Kumar Source Type: research

Molecular epidemiology of respiratory syncytial virus in hospitalised children in Heidelberg, Southern Germany, 2014-2017
CONCLUSION: Analysis of the molecular epidemiology of RSV from different seasons revealed the cocirculation and diversification of RSV genotypes ON1 and BAIX.PMID:35032683 | DOI:10.1016/j.meegid.2022.105209 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - January 15, 2022 Category: Genetics & Stem Cells Authors: J Tabatabai C M Ihling R M Rehbein S V Schnee J Hoos J Pfeil J Grulich-Henn P Schnitzler Source Type: research

Emerging role of γδ T cells in protozoan infection and their potential clinical application
Infect Genet Evol. 2022 Jan 11:105210. doi: 10.1016/j.meegid.2022.105210. Online ahead of print.ABSTRACTγδ T cells are thymus derived heterogeneous and unconventional T- lymphocyte expressing TCR γ (V γ9) and TCRδ (Vδ2) chain and play an important role in connecting innate and adaptive armaments of immune response. These cells can recognize wide ranges of antigens even without involvement of major histocompatibility complex and exert their biological functions by cytotoxicity or activating various types of immune cells. In recent past; γδ T cells have emerged as an important ...
Source: Infection, Genetics and Evolution - January 15, 2022 Category: Genetics & Stem Cells Authors: Awnish Kumar Bhawana Singh Rahul Tiwari Vishal Kumar Singh Siddharth Sankar Singh Shyam Sundar Rajiv Kumar Source Type: research

Molecular epidemiology of respiratory syncytial virus in hospitalised children in Heidelberg, Southern Germany, 2014-2017
CONCLUSION: Analysis of the molecular epidemiology of RSV from different seasons revealed the cocirculation and diversification of RSV genotypes ON1 and BAIX.PMID:35032683 | DOI:10.1016/j.meegid.2022.105209 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - January 15, 2022 Category: Genetics & Stem Cells Authors: J Tabatabai C M Ihling R M Rehbein S V Schnee J Hoos J Pfeil J Grulich-Henn P Schnitzler Source Type: research

Emerging role of γδ T cells in protozoan infection and their potential clinical application
Infect Genet Evol. 2022 Jan 11:105210. doi: 10.1016/j.meegid.2022.105210. Online ahead of print.ABSTRACTγδ T cells are thymus derived heterogeneous and unconventional T- lymphocyte expressing TCR γ (V γ9) and TCRδ (Vδ2) chain and play an important role in connecting innate and adaptive armaments of immune response. These cells can recognize wide ranges of antigens even without involvement of major histocompatibility complex and exert their biological functions by cytotoxicity or activating various types of immune cells. In recent past; γδ T cells have emerged as an important ...
Source: Infection, Genetics and Evolution - January 15, 2022 Category: Genetics & Stem Cells Authors: Awnish Kumar Bhawana Singh Rahul Tiwari Vishal Kumar Singh Siddharth Sankar Singh Shyam Sundar Rajiv Kumar Source Type: research

Phylogenetic and phenotypic characterization of two novel clade 2.3.2.1 H5N2 subtype avian influenza viruses from chickens in China
Infect Genet Evol. 2022 Jan 5;98:105205. doi: 10.1016/j.meegid.2022.105205. Online ahead of print.ABSTRACTThe extended co-circulation of H5 subtype highly pathogenic avian influenza (HPAI) viruses and H9N2 low pathogenic avian influenza (LPAI) viruses has inevitably facilitated gene reassortment between the two subtypes in fields. And, novel reassortant H5NX viruses harboring partial or even whole sets of H9N2 internal genes have continuously been detected, such as clade 2.3.4.4 H5N2 or H5N6 reassortants. Here, we report two novel H5N2 subtype HPAI isolates of HF9 and QY5 from chickens in live poultry markets during routin...
Source: Infection, Genetics and Evolution - January 9, 2022 Category: Genetics & Stem Cells Authors: Zhichuang Ge Lijun Xu Xiaomiao Hu Shanshan Zhu Ying Zhao Yang Li Kaituo Liu Ruyi Gao Xiaoquan Wang Jiao Hu Xiaowen Liu Shunlin Hu Daxin Peng Min Gu Xiufan Liu Source Type: research

Detection and genetic diversity of Mopeia virus in Mastomys natalensis from different habitats in the Limpopo National Park, Mozambique
In this study, rodents were trapped between March and November 2019in villages, croplands fields and mopane woodland forest. The aim was to assess the potential circulation and to evaluate the genetic diversity of mammarenaviruses in M. natalensis trapped in the Limpopo National Park and its buffer zone in Massingir district, Mozambique. A total of 534 M. natalensis were screened by RT-PCR and the overall proportion of positive individuals was 16.9%. No significant differences were detected between the sampled habitats (χ2 = 0.018; DF = 1; p = 0.893). The Mopeia virus (bootstrap value 91%) was the Mammarenavirus circul...
Source: Infection, Genetics and Evolution - January 9, 2022 Category: Genetics & Stem Cells Authors: Louren ço Mapaco Laurent Crespin D ércio Rodrigues Joelle Gouy de Bellocq Josef Bryja Mathieu Bourgarel Doroth ée Missé Alexandre Caron Jose Fafetine Julien Cappelle Florian Li égeois Source Type: research

Evaluation of miR-200c-3p and miR-421-5p levels during immune responses in the admitted and recovered COVID-19 subjects
Infect Genet Evol. 2022 Jan 5;98:105207. doi: 10.1016/j.meegid.2022.105207. Online ahead of print.ABSTRACTAngiotensin-converting enzyme 2 (ACE2) acts as a key receptor for the spike of SARS-CoV-2. Two main microRNAs (miRs), miR-200c-3p and miR-421-5p, are considered to modulate the expression of ACE2 gene and alterations in the expression of these miRNAs may influence the outcomes of COVID-19 infection. Accordingly, we examined whether miRNAs directing ACE2 expression altered in the SARS-CoV-2 infection. 30 patients with COVID-19 included in the study. At the time of admission and discharge, the expression of miR-200c-3p a...
Source: Infection, Genetics and Evolution - January 9, 2022 Category: Genetics & Stem Cells Authors: Shahrokh Abdolahi Maryam Hosseini Ramazan Rezaei Seyed Reza Mohebbi Mohammad Rostami-Nejad Ehsan Nazemalhosseini Mojarad Hamed Mirjalali Abbas Yadegar Hamid Asadzadeh Aghdaei Mohamad Reza Zali Kaveh Baghaei Source Type: research

The dynamic change of SARS-CoV-2 variants in Sierra Leone
Infect Genet Evol. 2022 Jan 6:105208. doi: 10.1016/j.meegid.2022.105208. Online ahead of print.ABSTRACTSince the beginning of the SARS-CoV-2 pandemic, the emergence of multiple new variants posed an increased risk to global public health. The aim of this study is to investigate SARS-CoV-2 variants and possible transmission of variants of concern (VOCs) in Sierra Leone. A total of 65 nasal swab samples were collected from COVID-19 cases in Sierra Leone, among which 24 samples were collected during the second wave and 41 samples were collected during the third wave. Nanopore sequencing generated 54 SARS-CoV-2 whole genomes. ...
Source: Infection, Genetics and Evolution - January 9, 2022 Category: Genetics & Stem Cells Authors: Lei Lin Juling Zhang James Rogers Allan Campbell Jianjun Zhao Doris Harding Foday Sahr Yongjian Liu Isata Wurie Source Type: research

Phylogenetic and phenotypic characterization of two novel clade 2.3.2.1 H5N2 subtype avian influenza viruses from chickens in China
Infect Genet Evol. 2022 Jan 5;98:105205. doi: 10.1016/j.meegid.2022.105205. Online ahead of print.ABSTRACTThe extended co-circulation of H5 subtype highly pathogenic avian influenza (HPAI) viruses and H9N2 low pathogenic avian influenza (LPAI) viruses has inevitably facilitated gene reassortment between the two subtypes in fields. And, novel reassortant H5NX viruses harboring partial or even whole sets of H9N2 internal genes have continuously been detected, such as clade 2.3.4.4 H5N2 or H5N6 reassortants. Here, we report two novel H5N2 subtype HPAI isolates of HF9 and QY5 from chickens in live poultry markets during routin...
Source: Infection, Genetics and Evolution - January 9, 2022 Category: Genetics & Stem Cells Authors: Zhichuang Ge Lijun Xu Xiaomiao Hu Shanshan Zhu Ying Zhao Yang Li Kaituo Liu Ruyi Gao Xiaoquan Wang Jiao Hu Xiaowen Liu Shunlin Hu Daxin Peng Min Gu Xiufan Liu Source Type: research

Detection and genetic diversity of Mopeia virus in Mastomys natalensis from different habitats in the Limpopo National Park, Mozambique
In this study, rodents were trapped between March and November 2019in villages, croplands fields and mopane woodland forest. The aim was to assess the potential circulation and to evaluate the genetic diversity of mammarenaviruses in M. natalensis trapped in the Limpopo National Park and its buffer zone in Massingir district, Mozambique. A total of 534 M. natalensis were screened by RT-PCR and the overall proportion of positive individuals was 16.9%. No significant differences were detected between the sampled habitats (χ2 = 0.018; DF = 1; p = 0.893). The Mopeia virus (bootstrap value 91%) was the Mammarenavirus circul...
Source: Infection, Genetics and Evolution - January 9, 2022 Category: Genetics & Stem Cells Authors: Louren ço Mapaco Laurent Crespin D ércio Rodrigues Joelle Gouy de Bellocq Josef Bryja Mathieu Bourgarel Doroth ée Missé Alexandre Caron Jose Fafetine Julien Cappelle Florian Li égeois Source Type: research

Evaluation of miR-200c-3p and miR-421-5p levels during immune responses in the admitted and recovered COVID-19 subjects
Infect Genet Evol. 2022 Jan 5;98:105207. doi: 10.1016/j.meegid.2022.105207. Online ahead of print.ABSTRACTAngiotensin-converting enzyme 2 (ACE2) acts as a key receptor for the spike of SARS-CoV-2. Two main microRNAs (miRs), miR-200c-3p and miR-421-5p, are considered to modulate the expression of ACE2 gene and alterations in the expression of these miRNAs may influence the outcomes of COVID-19 infection. Accordingly, we examined whether miRNAs directing ACE2 expression altered in the SARS-CoV-2 infection. 30 patients with COVID-19 included in the study. At the time of admission and discharge, the expression of miR-200c-3p a...
Source: Infection, Genetics and Evolution - January 9, 2022 Category: Genetics & Stem Cells Authors: Shahrokh Abdolahi Maryam Hosseini Ramazan Rezaei Seyed Reza Mohebbi Mohammad Rostami-Nejad Ehsan Nazemalhosseini Mojarad Hamed Mirjalali Abbas Yadegar Hamid Asadzadeh Aghdaei Mohamad Reza Zali Kaveh Baghaei Source Type: research

The dynamic change of SARS-CoV-2 variants in Sierra Leone
Infect Genet Evol. 2022 Jan 6:105208. doi: 10.1016/j.meegid.2022.105208. Online ahead of print.ABSTRACTSince the beginning of the SARS-CoV-2 pandemic, the emergence of multiple new variants posed an increased risk to global public health. The aim of this study is to investigate SARS-CoV-2 variants and possible transmission of variants of concern (VOCs) in Sierra Leone. A total of 65 nasal swab samples were collected from COVID-19 cases in Sierra Leone, among which 24 samples were collected during the second wave and 41 samples were collected during the third wave. Nanopore sequencing generated 54 SARS-CoV-2 whole genomes. ...
Source: Infection, Genetics and Evolution - January 9, 2022 Category: Genetics & Stem Cells Authors: Lei Lin Juling Zhang James Rogers Allan Campbell Jianjun Zhao Doris Harding Foday Sahr Yongjian Liu Isata Wurie Source Type: research

Phylogenetic and phenotypic characterization of two novel clade 2.3.2.1 H5N2 subtype avian influenza viruses from chickens in China
Infect Genet Evol. 2022 Jan 5:105205. doi: 10.1016/j.meegid.2022.105205. Online ahead of print.ABSTRACTThe extended co-circulation of H5 subtype highly pathogenic avian influenza (HPAI) viruses and H9N2 low pathogenic avian influenza (LPAI) viruses has inevitably facilitated gene reassortment between the two subtypes in fields. And, novel reassortant H5NX viruses harboring partial or even whole sets of H9N2 internal genes have continuously been detected, such as clade 2.3.4.4 H5N2 or H5N6 reassortants. Here, we report two novel H5N2 subtype HPAI isolates of HF9 and QY5 from chickens in live poultry markets during routine s...
Source: Infection, Genetics and Evolution - January 9, 2022 Category: Genetics & Stem Cells Authors: Zhichuang Ge Lijun Xu Xiaomiao Hu Shanshan Zhu Ying Zhao Yang Li Kaituo Liu Ruyi Gao Xiaoquan Wang Jiao Hu Xiaowen Liu Shunlin Hu Daxin Peng Min Gu Xiufan Liu Source Type: research

Detection and genetic diversity of Mopeia virus in Mastomys natalensis from different habitats in the Limpopo National Park, Mozambique
In this study, rodents were trapped between March and November 2019in villages, croplands fields and mopane woodland forest. The aim was to assess the potential circulation and to evaluate the genetic diversity of mammarenaviruses in M. natalensis trapped in the Limpopo National Park and its buffer zone in Massingir district, Mozambique. A total of 534 M. natalensis were screened by RT-PCR and the overall proportion of positive individuals was 16.9%. No significant differences were detected between the sampled habitats ((χ2 = 0.018; DF = 1; p = 0.893)). TheMopeia virus (bootstrap value 91%) was the Mammarenavirus circu...
Source: Infection, Genetics and Evolution - January 9, 2022 Category: Genetics & Stem Cells Authors: Louren ço Mapaco Laurent Crespin D ércio Rodrigues Joelle Gouy de Bellocq Josef Bryja Mathieu Bourgarel Doroth ée Missé Alexandre Caron Jose Fafetine Julien Cappelle Florian Li égeois Source Type: research

Evaluation of miR-200c-3p and miR-421-5p levels during immune responses in the admitted and recovered COVID-19 subjects
Infect Genet Evol. 2022 Jan 5;98:105207. doi: 10.1016/j.meegid.2022.105207. Online ahead of print.ABSTRACTAngiotensin-converting enzyme 2 (ACE2) acts as a key receptor for the spike of SARS-CoV-2. Two main microRNAs (miRs), miR-200c-3p and miR-421-5p, are considered to modulate the expression of ACE2 gene and alterations in the expression of these miRNAs may influence the outcomes of COVID-19 infection. Accordingly, we examined whether miRNAs directing ACE2 expression altered in the SARS-CoV-2 infection. 30 patients with COVID-19 included in the study. At the time of admission and discharge, the expression of miR-200c-3p a...
Source: Infection, Genetics and Evolution - January 9, 2022 Category: Genetics & Stem Cells Authors: Shahrokh Abdolahi Maryam Hosseini Ramazan Rezaei Seyed Reza Mohebbi Mohammad Rostami-Nejad Ehsan Nazemalhosseini Mojarad Hamed Mirjalali Abbas Yadegar Hamid Assadzadeh-Aghdaei Mohamad Reza Zali Kaveh Baghaei Source Type: research

The dynamic change of SARS-CoV-2 variants in Sierra Leone
Infect Genet Evol. 2022 Jan 6:105208. doi: 10.1016/j.meegid.2022.105208. Online ahead of print.ABSTRACTSince the beginning of the SARS-CoV-2 pandemic, the emergence of multiple new variants posed an increased risk to global public health. The aim of this study is to investigate SARS-CoV-2 variants and possible transmission of variants of concern (VOCs) in Sierra Leone. A total of 65 nasal swab samples were collected from COVID-19 cases in Sierra Leone, among which 24 samples were collected during the second wave and 41 samples were collected during the third wave. Nanopore sequencing generated 54 SARS-CoV-2 whole genomes. ...
Source: Infection, Genetics and Evolution - January 9, 2022 Category: Genetics & Stem Cells Authors: Lei Lin Juling Zhang James Rogers Allan Campbell Jianjun Zhao Doris Harding Foday Sahr Yongjian Liu Isata Wurie Source Type: research

Phylogenetic and phenotypic characterization of two novel clade 2.3.2.1 H5N2 subtype avian influenza viruses from chickens in China
Infect Genet Evol. 2022 Jan 5:105205. doi: 10.1016/j.meegid.2022.105205. Online ahead of print.ABSTRACTThe extended co-circulation of H5 subtype highly pathogenic avian influenza (HPAI) viruses and H9N2 low pathogenic avian influenza (LPAI) viruses has inevitably facilitated gene reassortment between the two subtypes in fields. And, novel reassortant H5NX viruses harboring partial or even whole sets of H9N2 internal genes have continuously been detected, such as clade 2.3.4.4 H5N2 or H5N6 reassortants. Here, we report two novel H5N2 subtype HPAI isolates of HF9 and QY5 from chickens in live poultry markets during routine s...
Source: Infection, Genetics and Evolution - January 9, 2022 Category: Genetics & Stem Cells Authors: Zhichuang Ge Lijun Xu Xiaomiao Hu Shanshan Zhu Ying Zhao Yang Li Kaituo Liu Ruyi Gao Xiaoquan Wang Jiao Hu Xiaowen Liu Shunlin Hu Daxin Peng Min Gu Xiufan Liu Source Type: research

Detection and genetic diversity of Mopeia virus in Mastomys natalensis from different habitats in the Limpopo National Park, Mozambique
In this study, rodents were trapped between March and November 2019in villages, croplands fields and mopane woodland forest. The aim was to assess the potential circulation and to evaluate the genetic diversity of mammarenaviruses in M. natalensis trapped in the Limpopo National Park and its buffer zone in Massingir district, Mozambique. A total of 534 M. natalensis were screened by RT-PCR and the overall proportion of positive individuals was 16.9%. No significant differences were detected between the sampled habitats ((χ2 = 0.018; DF = 1; p = 0.893)). TheMopeia virus (bootstrap value 91%) was the Mammarenavirus circu...
Source: Infection, Genetics and Evolution - January 9, 2022 Category: Genetics & Stem Cells Authors: Louren ço Mapaco Laurent Crespin D ércio Rodrigues Joelle Gouy de Bellocq Josef Bryja Mathieu Bourgarel Doroth ée Missé Alexandre Caron Jose Fafetine Julien Cappelle Florian Li égeois Source Type: research

Evaluation of miR-200c-3p and miR-421-5p levels during immune responses in the admitted and recovered COVID-19 subjects
Infect Genet Evol. 2022 Jan 5:105207. doi: 10.1016/j.meegid.2022.105207. Online ahead of print.ABSTRACTAngiotensin-converting enzyme 2 (ACE2) acts as a key receptor for the spike of SARS-CoV-2. Two main microRNAs (miRs), miR-200c-3p and miR-421-5p, are considered to modulate the expression of ACE2 gene and alterations in the expression of these miRNAs may influence the outcomes of COVID-19 infection. Accordingly, we examined whether miRNAs directing ACE2 expression altered in the SARS-CoV-2 infection. 30 patients with COVID-19 included in the study. At the time of admission and discharge, the expression of miR-200c-3p and ...
Source: Infection, Genetics and Evolution - January 9, 2022 Category: Genetics & Stem Cells Authors: Shahrokh Abdolahi Maryam Hosseini Ramazan Rezaei Seyed Reza Mohebbi Mohammad Rostami-Nejad Ehsan Nazemalhosseini Mojarad Hamed Mirjalali Abbas Yadegar Hamid Assadzadeh-Aghdaei Mohamad Reza Zali Kaveh Baghaei Source Type: research

The dynamic change of SARS-CoV-2 variants in Sierra Leone
Infect Genet Evol. 2022 Jan 6:105208. doi: 10.1016/j.meegid.2022.105208. Online ahead of print.ABSTRACTSince the beginning of the SARS-CoV-2 pandemic, the emergence of multiple new variants posed an increased risk to global public health. The aim of this study is to investigate SARS-CoV-2 variants and possible transmission of variants of concern (VOCs) in Sierra Leone. A total of 65 nasal swab samples were collected from COVID-19 cases in Sierra Leone, among which 24 samples were collected during the second wave and 41 samples were collected during the third wave. Nanopore sequencing generated 54 SARS-CoV-2 whole genomes. ...
Source: Infection, Genetics and Evolution - January 9, 2022 Category: Genetics & Stem Cells Authors: Lei Lin Juling Zhang James Rogers Allan Campbell Jianjun Zhao Doris Harding Foday Sahr Yongjian Liu Isata Wurie Source Type: research

Genetic association of TMPRSS2 rs2070788 polymorphism with COVID-19 case fatality rate among Indian populations
Infect Genet Evol. 2022 Jan 5;98:105206. doi: 10.1016/j.meegid.2022.105206. Online ahead of print.ABSTRACTSARS-CoV-2, the causative agent for COVID-19, an ongoing pandemic, engages the ACE2 receptor to enter the host cell through S protein priming by a serine protease, TMPRSS2. Variation in the TMPRSS2 gene may account for the disparity in disease susceptibility between populations. Therefore, in the present study, we have used next-generation sequencing (NGS) data of world populations from 393 individuals and analyzed the TMPRSS2 gene using a haplotype-based approach with a major focus on South Asia to study its phylogene...
Source: Infection, Genetics and Evolution - January 7, 2022 Category: Genetics & Stem Cells Authors: Rudra Kumar Pandey Anshika Srivastava Prajjval Pratap Singh Gyaneshwer Chaubey Source Type: research

Genetic association of TMPRSS2 rs2070788 polymorphism with COVID-19 case fatality rate among Indian populations
Infect Genet Evol. 2022 Jan 4;98:105206. doi: 10.1016/j.meegid.2022.105206. Online ahead of print.ABSTRACTSARS-CoV2, the causative agent for COVID-19, an ongoing pandemic, engages the ACE2 receptor to enter the host cell through S protein priming by a serine protease, TMPRSS2. Variation in the TMPRSS2 gene may account for the disparity in disease susceptibility between populations. Therefore, in the present study, we have used next-generation sequencing (NGS) data of world populations from 393 individuals and analyzed the TMPRSS2 gene using a haplotype-based approach with a major focus on South Asia to study its phylogenet...
Source: Infection, Genetics and Evolution - January 7, 2022 Category: Genetics & Stem Cells Authors: Rudra Kumar Pandey Anshika Srivastava Prajjval Pratap Singh Gyaneshwer Chaubey Source Type: research

Effect of PITX2 genetic variants on the susceptibility to stroke in the Chinese Han population
CONCLUSIONS: This study indicated that there was a significant association between the PITX2 gene and stroke risk, and provided some data as far as possible to support the prevention of stroke.PMID:34990849 | DOI:10.1016/j.meegid.2021.105201 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - January 6, 2022 Category: Genetics & Stem Cells Authors: Weiwei Zhao Xiuxia Hu Jie Hao Le Guo Wenjie Zhang Jianfeng Liu Tianbo Jin Dakuan Gao Jin Zhi Source Type: research

Polymorphisms of SLC11A1(NRAMP1) rs17235409 associated with and susceptibility to spinal tuberculosis in a southern Han Chinese population
CONCLUSIONS: Variant genotypes at the rs17235409 locus of the SLC11A1 gene are associated with STB in the southern Han Chinese population. NRAMP1 protein expression is increased in patients with spinal tuberculosis, and the presence of the A allele increases the risk of developing STB.PMID:34990850 | DOI:10.1016/j.meegid.2021.105202 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - January 6, 2022 Category: Genetics & Stem Cells Authors: Tao Li Longjie Wang Chaofeng Guo Hongqi Zhang Peng Xu Shaohua Liu Xiaojiang Hu Qile Gao Source Type: research

Human genetic polymorphism and Leishmaniasis
Infect Genet Evol. 2022 Jan 3:105203. doi: 10.1016/j.meegid.2021.105203. Online ahead of print.ABSTRACTLeishmaniasis is a disease of the subtropical and tropical spheres of the earth and has various clinical manifestations. The different form of leishmaniasis includes cutaneous leishmaniasis, mucocutaneous leishmaniasis, most lethal visceral leishmaniasis and PKDL form. These different forms depend on many factors such as parasite and vector species, geographical, environmental conditions and population ethnicity. Host genetic factors have been widely investigated for their role in developing the disease in various infecti...
Source: Infection, Genetics and Evolution - January 6, 2022 Category: Genetics & Stem Cells Authors: Kavita Bharati Source Type: research

Molecular detection of Mansonella mariae incriminates Simulium oyapockense as a potentially important bridge vector for Amazon-region zoonoses
CONCLUSIONS: Our results show that residents of the periurban regions of São Gabriel da Cachoeira are routinely exposed to the bites of S. oyapockense blackflies which have previously fed on non-human primates.PMID:34990852 | DOI:10.1016/j.meegid.2021.105200 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - January 6, 2022 Category: Genetics & Stem Cells Authors: T úllio Romão Ribeiro da Silva Luiz Henrique de Aquino Narzetti James Lee Crainey Carlos Henrique Costa Yago Vin ícius Serra Dos Santos Lorena Ferreira de Oliveira Leles Felipe Arley Costa Pessoa Ana Carolina Paulo Vicente S érgio Luiz Bessa Luz Source Type: research