Increased prevalence of pretreatment drug resistance mutations in treatment-na ïve people living with HIV-1 in Henan Province, China (2022/23)
Infect Genet Evol. 2023 Oct 26:105520. doi: 10.1016/j.meegid.2023.105520. Online ahead of print.ABSTRACTHuman deficiency virus type 1 (HIV-1) harboring drug resistance mutations (DRMs) before the initiation of antiretroviral therapy (ART) poses a serious threat to the efficacy of current ART regimens. Currently, the prevalence of pre-treatment drug resistance mutations (PDRMs) including transmitted DRMs (TDRMs) is not completely clear. Understanding this prevalence better should offer valuable data for clinical- and government-level decision-making. To closely monitor the PDRM trend in treatment-naïve people living with H...
Source: Infection, Genetics and Evolution - October 28, 2023 Category: Genetics & Stem Cells Authors: Jinjin Liu Chunli Liu Yanli Wang Shuguang Wei Jie Ma Yuanyuan Li Xuhui Chen Qingxia Zhao Yuqi Huo Source Type: research
Invasive non-typhoidal Salmonella (iNTS) aminoglycoside-resistant ST313 isolates feature unique pathogenic mechanisms to reach the bloodstream
In conclusion, we evidenced that S. Typhimurium ST313 strains isolated in Brazil have unique epidemiology. The elevated frequencies of virulence genes such as sseJ, sopD2, and pipB are a major concern in these Brazilian isolates, showing a higher pathogenic potential.PMID:37890808 | DOI:10.1016/j.meegid.2023.105519 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - October 27, 2023 Category: Genetics & Stem Cells Authors: Isabela Mancini Martins Amanda Aparecida Seribelli Tamara R Machado Ribeiro Patrick da Silva Bruna Cardinali Lustri Rodrigo T Hernandes Juliana Pfrimer Falc ão Cristiano Gallina Moreira Source Type: research
Genomic analysis of two rare human G3P[9] rotavirus strains in Ningxia, China
Infect Genet Evol. 2023 Oct 25:105518. doi: 10.1016/j.meegid.2023.105518. Online ahead of print.ABSTRACTG3P (Matthijnssens et al., 2008b [9]) is a rare combination of human rotavirus VP7/VP4 genotypes with a complex evolutionary pattern but limited related studies. Detailed genomic characterisation and genetic evolutionary analyses of G3P (Matthijnssens et al., 2008b [9]) rotaviruses have helped to enhance our understanding of rotavirus diversity. For the first time, we detected two human G3P (Matthijnssens et al., 2008b [9]) Rotavirus A (RVA) strains, RVA/Human-tc/CHN/2020999/2020/G3P (Matthijnssens et al., 2008b [9]) and...
Source: Infection, Genetics and Evolution - October 27, 2023 Category: Genetics & Stem Cells Authors: Min Cao Fang Yuan Wei Zhang Xiuqin Wang Jiangtao Ma Xuemin Ma Wenhe Kuai Xueping Ma Source Type: research
Genomic diversity and natural recombination of equid gammaherpesvirus 5 isolates
CONCLUSION: Genomic diversity and recombination hotspots were identified among EHV5 strains. Recombination can drive genetic diversity, particularly in viruses that have a low rate of nucleotide substitutions. Therefore, the results from this study suggest that recombination is an important contributing factor to EHV5 genomic diversity. The findings from this study provide additional insights into the genetic heterogeneity of the EHV5 genome.PMID:37879385 | DOI:10.1016/j.meegid.2023.105517 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - October 25, 2023 Category: Genetics & Stem Cells Authors: Adepeju E Onasanya Charles El-Hage Andr és Diaz-Méndez Paola K Vaz Alistair R Legione Joanne M Devlin Carol A Hartley Source Type: research
Genomic diversity and natural recombination of equid gammaherpesvirus 5 isolates
CONCLUSION: Genomic diversity and recombination hotspots were identified among EHV5 strains. Recombination can drive genetic diversity, particularly in viruses that have a low rate of nucleotide substitutions. Therefore, the results from this study suggest that recombination is an important contributing factor to EHV5 genomic diversity. The findings from this study provide additional insights into the genetic heterogeneity of the EHV5 genome.PMID:37879385 | DOI:10.1016/j.meegid.2023.105517 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - October 25, 2023 Category: Genetics & Stem Cells Authors: Adepeju E Onasanya Charles El-Hage Andr és Diaz-Méndez Paola K Vaz Alistair R Legione Joanne M Devlin Carol A Hartley Source Type: research
Genomic diversity and natural recombination of equid gammaherpesvirus 5 isolates
CONCLUSION: Genomic diversity and recombination hotspots were identified among EHV5 strains. Recombination can drive genetic diversity, particularly in viruses that have a low rate of nucleotide substitutions. Therefore, the results from this study suggest that recombination is an important contributing factor to EHV5 genomic diversity. The findings from this study provide additional insights into the genetic heterogeneity of the EHV5 genome.PMID:37879385 | DOI:10.1016/j.meegid.2023.105517 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - October 25, 2023 Category: Genetics & Stem Cells Authors: Adepeju E Onasanya Charles El-Hage Andr és Diaz-Méndez Paola K Vaz Alistair R Legione Joanne M Devlin Carol A Hartley Source Type: research
Detection and genetic evolution analysis of porcine parvovirus type 7 (PPV7) in Fujian Province
This study provides significant insights into the molecular characteristics of PPV7 in Fujian Province and serves as a crucial foundation for further advancements in PPV7 prevention and control strategies.PMID:37866684 | DOI:10.1016/j.meegid.2023.105515 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - October 22, 2023 Category: Genetics & Stem Cells Authors: Zixin Lyu Xinjie Zhang Shaohua Xue Xiaoyan Yang Jiankui Liu Kewei Fan Ailing Dai Source Type: research
Detection and genetic evolution analysis of porcine parvovirus type 7 (PPV7) in Fujian Province
This study provides significant insights into the molecular characteristics of PPV7 in Fujian Province and serves as a crucial foundation for further advancements in PPV7 prevention and control strategies.PMID:37866684 | DOI:10.1016/j.meegid.2023.105515 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - October 22, 2023 Category: Genetics & Stem Cells Authors: Zixin Lyu Xinjie Zhang Shaohua Xue Xiaoyan Yang Jiankui Liu Kewei Fan Ailing Dai Source Type: research
Detection and genetic evolution analysis of porcine parvovirus type 7 (PPV7) in Fujian Province
This study provides significant insights into the molecular characteristics of PPV7 in Fujian Province and serves as a crucial foundation for further advancements in PPV7 prevention and control strategies.PMID:37866684 | DOI:10.1016/j.meegid.2023.105515 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - October 22, 2023 Category: Genetics & Stem Cells Authors: Zixin Lyu Xinjie Zhang Shaohua Xue Xiaoyan Yang Jiankui Liu Kewei Fan Ailing Dai Source Type: research
HIV-1 subtypes maintain distinctive physicochemical signatures in Nef domains associated with immunoregulation
CONCLUSIONS: Recent studies have focused on HIV Nef as a driver of immunoregulatory disease in those HIV infected and on ART. Nef acts through a complex mixture of interactions that are directly linked to the key features of the subtype-specific domains we identified with the ENN. The study supports the hypothesis that varied Nef subtypes contribute to subtype-specific disease progression.PMID:37832752 | DOI:10.1016/j.meegid.2023.105514 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - October 13, 2023 Category: Genetics & Stem Cells Authors: Susanna L Lamers Gary B Fogel Enoch S Liu David J Nolan Rebecca Rose Michael S McGrath Source Type: research
Highly diverse dynamics of Pseudomonas aeruginosa colonization from initial detection in cystic fibrosis patients: A 7-year longitudinal genetic diversity study
Infect Genet Evol. 2023 Oct 11;115:105513. doi: 10.1016/j.meegid.2023.105513. Online ahead of print.ABSTRACTIn cystic fibrosis (CF), Pseudomonas aeruginosa (Pa) is a major pathogen that can persistently colonize patients. Genetic studies showed a high diversity of Pa, the success of widespread or 'international' clones and described epidemic clones in CF and Epidemic High-Risk (ERH) clones. Here, we characterized Pa genetic diversity over time after first colonization in CF patients, with the aim of accurately describing the dynamics of colonization in a context of scarce longitudinal studies including the first isolated P...
Source: Infection, Genetics and Evolution - October 13, 2023 Category: Genetics & Stem Cells Authors: Chlo é Dupont Fabien Aujoulat Massilia Benaoudia Estelle Jumas-Bilak Rapha ël Chiron H élène Marchandin Source Type: research
HIV-1 subtypes maintain distinctive physicochemical signatures in Nef domains associated with immunoregulation
CONCLUSIONS: Recent studies have focused on HIV Nef as a driver of immunoregulatory disease in those HIV infected and on ART. Nef acts through a complex mixture of interactions that are directly linked to the key features of the subtype-specific domains we identified with the ENN. The study supports the hypothesis that varied Nef subtypes contribute to subtype-specific disease progression.PMID:37832752 | DOI:10.1016/j.meegid.2023.105514 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - October 13, 2023 Category: Genetics & Stem Cells Authors: Susanna L Lamers Gary B Fogel Enoch S Liu David J Nolan Rebecca Rose Michael S McGrath Source Type: research
Highly diverse dynamics of Pseudomonas aeruginosa colonization from initial detection in cystic fibrosis patients: A 7-year longitudinal genetic diversity study
Infect Genet Evol. 2023 Oct 11;115:105513. doi: 10.1016/j.meegid.2023.105513. Online ahead of print.ABSTRACTIn cystic fibrosis (CF), Pseudomonas aeruginosa (Pa) is a major pathogen that can persistently colonize patients. Genetic studies showed a high diversity of Pa, the success of widespread or 'international' clones and described epidemic clones in CF and Epidemic High-Risk (ERH) clones. Here, we characterized Pa genetic diversity over time after first colonization in CF patients, with the aim of accurately describing the dynamics of colonization in a context of scarce longitudinal studies including the first isolated P...
Source: Infection, Genetics and Evolution - October 13, 2023 Category: Genetics & Stem Cells Authors: Chlo é Dupont Fabien Aujoulat Massilia Benaoudia Estelle Jumas-Bilak Rapha ël Chiron H élène Marchandin Source Type: research
HIV-1 subtypes maintain distinctive physicochemical signatures in Nef domains associated with immunoregulation
CONCLUSIONS: Recent studies have focused on HIV Nef as a driver of immunoregulatory disease in those HIV infected and on ART. Nef acts through a complex mixture of interactions that are directly linked to the key features of the subtype-specific domains we identified with the ENN. The study supports the hypothesis that varied Nef subtypes contribute to subtype-specific disease progression.PMID:37832752 | DOI:10.1016/j.meegid.2023.105514 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - October 13, 2023 Category: Genetics & Stem Cells Authors: Susanna L Lamers Gary B Fogel Enoch S Liu David J Nolan Rebecca Rose Michael S McGrath Source Type: research
Highly diverse dynamics of Pseudomonas aeruginosa colonization from initial detection in cystic fibrosis patients: A 7-year longitudinal genetic diversity study
Infect Genet Evol. 2023 Oct 11:105513. doi: 10.1016/j.meegid.2023.105513. Online ahead of print.ABSTRACTIn cystic fibrosis (CF), Pseudomonas aeruginosa (Pa) is a major pathogen that can persistently colonize patients. Genetic studies showed a high diversity of Pa, the success of widespread or 'international' clones and described epidemic clones in CF and Epidemic High-Risk (ERH) clones. Here, we characterized Pa genetic diversity over time after first colonization in CF patients, with the aim of accurately describing the dynamics of colonization in a context of scarce longitudinal studies. Results represent the first genot...
Source: Infection, Genetics and Evolution - October 13, 2023 Category: Genetics & Stem Cells Authors: Chlo é Dupont Fabien Aujoulat Massilia Benaoudia Estelle Jumas-Bilak Rapha ël Chiron H élène Marchandin Source Type: research
