Antibiotics efficacy in clinical and microbiological cure of uncomplicated urinary tract infection: a systematic review and network meta-analysis
ConclusionThe network meta-analysis demonstrated that Fosfomycin is the most effective antibiotic in treating uncomplicated UTIs with respect to clinical cure, microbiological cure, and adverse events profile. (Source: World Journal of Urology)
Source: World Journal of Urology - April 8, 2024 Category: Urology & Nephrology Source Type: research
Molecules, Vol. 29, Pages 1685: Phenylspirodrimane with Moderate Reversal Effect of Multidrug Resistance Isolated from the Deep-Sea Fungus Stachybotrys sp. 3A00409
en
Zhiqiang Zhang
Two new phenylspirodrimanes, stachybotrins K and L (1 and 2), together with eight known analogues (3–10), were isolated from deep-sea-derived Stachybotrys sp. MCCC 3A00409. Their structures were determined by extensive NMR data and mass spectroscopic analysis. Absolute configurations of new compounds were determined through a comparison of their circular dichroism (CD) spectra with other reported compounds. The possible reversal effects of all compounds were assayed in the resistant cancer cell lines. Stachybotrysin B (8) can reverse multidrug resistance (MDR) in ABCB1-overexpression c...
Source: Molecules - April 8, 2024 Category: Chemistry Authors: Xinhua Ma Min Wu Zhenwei Chen Fan Cao Tianhua Zhong Zhuhua Luo Zongze Shao Yonghong Zhang Limin Chen Zhiqiang Zhang Tags: Article Source Type: research
GSE249483 Antibacterial activities of the algal bromophenol methylrhodomelol against Pseudomonas aeruginosa
Contributors : Joshua Jacobtorweihen ; Anja Hartmann ; Stefanie Hofer ; Verena SpieglerSeries Type : Expression profiling by high throughput sequencingOrganism : Pseudomonas aeruginosaMethylrhodomelol (1) is a bromophenol from the red alga Vertebrata lanosa (L.) T.A.Christensen that has been associated with antimicrobial properties. Aim of the current study was therefore, to assess the antimicrobial potential of this compound in more detail against the gram-negative pathogen Pseudomonas aeruginosa. 1 exerted weak bacteriostatic activity against different strains when grown in minimal medium, whereas other phenolics wer...
Source: GEO: Gene Expression Omnibus - April 7, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Pseudomonas aeruginosa Source Type: research
Endophytes: a uniquely tailored source of potential antibiotic adjuvants
Arch Microbiol. 2024 Apr 6;206(5):207. doi: 10.1007/s00203-024-03891-y.ABSTRACTMultidrug microbial resistance is risking an annual loss of more than 10 million people' lives by 2050. Solutions include the rational use of antibiotics and the use of drugs that reduce resistance or completely obliterate them. Here endophytes come to play due to their high-yield production and inherent nature to produce antimicrobial molecules. Around 40%, 45% and 17% of antibacterial agents were obtained from fungi, actinomycetes, and bacteria, respectively, whose secondary metabolites revealed effectiveness against resistant microbes such as...
Source: Archives of Microbiology - April 6, 2024 Category: Microbiology Authors: Ashaimaa Y Moussa Source Type: research
Endophytes: a uniquely tailored source of potential antibiotic adjuvants
Arch Microbiol. 2024 Apr 6;206(5):207. doi: 10.1007/s00203-024-03891-y.ABSTRACTMultidrug microbial resistance is risking an annual loss of more than 10 million people' lives by 2050. Solutions include the rational use of antibiotics and the use of drugs that reduce resistance or completely obliterate them. Here endophytes come to play due to their high-yield production and inherent nature to produce antimicrobial molecules. Around 40%, 45% and 17% of antibacterial agents were obtained from fungi, actinomycetes, and bacteria, respectively, whose secondary metabolites revealed effectiveness against resistant microbes such as...
Source: Archives of Microbiology - April 6, 2024 Category: Microbiology Authors: Ashaimaa Y Moussa Source Type: research
Neonatal < em > Elizabethkingia anophelis < /em > meningitis originating from the water reservoir of an automated infant milk dispenser, the Netherlands, February 2024
We report a Dutch case of E. anophelis meningitis in a neonate, clonally related to samples taken from an automated infant milk dispenser located at the family's residence. We inform about the emergence of E. anophelis and suggest molecular surveillance in hospitals and other health settings. This is the first case connecting an automated formula dispenser to an invasive infection in a neonate.PMID:38577802 | DOI:10.2807/1560-7917.ES.2024.29.14.2400177 (Source: Euro Surveill)
Source: Euro Surveill - April 5, 2024 Category: Infectious Diseases Authors: B Ruben Brandsema Ger-Jan Fleurke Sigrid Rosema Eke Mw Schins Jelte Helfferich Erik Bathoorn Source Type: research
Antimicrobial Resistance Patterns in Patients with Vaginal Discharge: A 2019-2022 Analysis at the National Health Laboratory in Eritrea
CONCLUSION: Most gram-negative bacteria displayed higher resistance of >45% to ampicillin, trimethoprim-sulfamethoxazole, and tetracycline. Among gram-positive bacteria, a higher resistance rate with ampicillin, trimethoprim-sulfamethoxazole, tetracycline, oxacillin, vancomycin, and penicillin G was recorded. S. aureus showed no resistance to rifampicin and clindamycin, and Strep. spp. indicated 100% resistance to rifampicin and vancomycin. This study highlights critical gaps and areas for further exploration. Expanding the spectrum of antibiotics tested and investigating underlying multidrug resistance mechanisms would...
Source: Biomed Res - April 5, 2024 Category: Research Authors: Khalid Hussein Berhe Tesfai Okbu Frezgi Hagos Hayelom Yosan Gebremeskel Azania Werede Hailemichael Gebremariam Fitsum Kibreab Mohammed Elfatih Hamida Source Type: research
Cryo-EM structure of P-glycoprotein bound to triple elacridar inhibitor molecules
In this study, we have obtained a higher resolution (2.5 Å) structure of the P-gp- Fab (UIC2) complex bound by three elacridar molecules. This finding, which exposes a larger space for compound-binding sites than previously acknowledged, has significant implications for the development of more selective inhibitors and enhances our understanding of the compound recognition mechanism of P-gp.PMID:38579618 | DOI:10.1016/j.bbrc.2024.149855 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - April 5, 2024 Category: Biochemistry Authors: Norie Hamaguchi-Suzuki Naruhiko Adachi Toshio Moriya Satoshi Yasuda Masato Kawasaki Kano Suzuki Satoshi Ogasawara Naohiko Anzai Toshiya Senda Takeshi Murata Source Type: research
