Multidrug Resistance Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A review on potential heterocycles for the treatment of glioblastoma targeting receptor tyrosine kinases
Oncol Res. 2024 Apr 23;32(5):849-875. doi: 10.32604/or.2024.047042. eCollection 2024.ABSTRACTGlioblastoma, the most aggressive form of brain tumor, poses significant challenges in terms of treatment success and patient survival. Current treatment modalities for glioblastoma include radiation therapy, surgical intervention, and chemotherapy. Unfortunately, the median survival rate remains dishearteningly low at 12-15 months. One of the major obstacles in treating glioblastoma is the recurrence of tumors, making chemotherapy the primary approach for secondary glioma patients. However, the efficacy of drugs is hampered by the...
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Nilam Bhusare Maushmi Kumar Source Type: research

 In vitro Antibacterial Activity of Ethanolic Tanao Si Kan Dang RD1 ( Cannabis sativa L.) Extracts Against Human Antibiotic-Resistant Bacteria
Conclusion: This study presents a novel finding regarding the antibacterial activity of ethanolic extracts from the leaves and stems of Tanao Si Kan Dang RD1 against antibiotic-resistant bacteria. The potential application of these cannabis plant extracts in the development of antibiotics capable of combating antibiotic-resistant pathogenic bacteria represents a promising strategy to address a significant global health concern.PMID:38686733 | DOI:10.3923/pjbs.2024.119.124 (Source: Pakistan Journal of Biological Sciences: PJBS)
Source: Pakistan Journal of Biological Sciences: PJBS - April 30, 2024 Category: Biomedical Science Authors: Nipaporn Armassa Duanpen Wongsorn Benya Saenmahayak Somsak Rayan Surachai Rattanasuk Source Type: research

IJERPH, Vol. 21, Pages 574: Surveillance of Bacterial Load and Multidrug-Resistant Bacteria on Surfaces of Public Restrooms
In conclusion, the study underscores the significance of monitoring bacterial contamination in public restrooms and the need for measures to reduce the spread of infectious diseases. Further research is crucial to gain a complete understanding of the bacterial contamination in public restrooms and their resistance patterns, to ensure the safety and health of the public. The implementation of improved cleaning practices and hands-free designs in addition to the installation of antimicrobial surfaces in restrooms can help reduce the risk of cross-contamination and prevent the spread of diseases. (Source: International Journa...
Source: International Journal of Environmental Research and Public Health - April 30, 2024 Category: Environmental Health Authors: Khadega Ibrahim Maisha Tahsin Aninda Rahman Shaikh Mizanoor Rahman Md Mizanur Rahman Tags: Article Source Type: research

Delineating the evolutionary pathway to multidrug-resistant outbreaks of a Mycobacterium tuberculosis L4.1.2.1/Haarlem sublineage
Multidrug-resistant tuberculosis (MDR-TB) is caused by TB bacteria that are resistant to at least isoniazid and rifampicin, the two most potent TB drugs. This form of TB infection remains a major public health concern globally, which has been exacerbated by the HIV epidemic. The recent advent of the COVID-19 pandemic has further severely complicated the situation, by disrupting healthcare systems. Indeed, the burden of MDR-TB increased by 3% between 2020 and 2021, with 450 000 new cases of rifampicin-resistant TB in 2021, thus hampering the global TB control efforts [1]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 30, 2024 Category: Infectious Diseases Authors: Naira Dekhil, Helmi Mardassi Source Type: research

Efficacy of an inulin-based treatment on intestinal colonization by multidrug-resistant E. coli: insight into the mechanism of action
Volume 16, Issue 1, January-December 2024 . (Source: Gut Microbes)
Source: Gut Microbes - April 30, 2024 Category: Microbiology Authors: Murad IshnaiwerQuentin Le BastardMaxime NaourMichal ZemanEric DaillyEmmanuel MontassierEric BatardMichel Diona Nantes Universit é, CHU Nantes, Cibles et médicaments des infections et du cancer, IICiMed, Nantes, Franceb College of Applied Sciences, Pales Source Type: research

Multidrug ‐resistant Stenotrophomonas maltophilia in residential aged care facilities: An emerging threat
This study marks the first assessment of the prevalence, resistome, and genomic characteristics of multidrug-resistant (MDR)Stenotrophomonas maltophilia in residential aged care facilities. MDRS. maltophilia were found in all sampled facilities, with colistin non-wild type and trimethoprim-sulfamethoxazole resistant isolates recovered. Many isolates also exhibited high tolerance to triclosan and benzalkonium chloride. Notably, our findings indicate the continued emergence ofS. maltophilia, with lineages not previously identified in Australia observed in this study. This underscores the urgent need for comprehensive surveil...
Source: MicrobiologyOpen - April 29, 2024 Category: Microbiology Authors: Sylvia A. Sapula, Bradley J. Hart, Naomi L. Siderius, Anteneh Amsalu, Jack M. Blaikie, Henrietta Venter Tags: ORIGINAL ARTICLE Source Type: research

A small step towards an important goal: fragment screen of the c-di-AMP-synthesizing enzyme CdaA
CdaA is the most widespread diadenylate cyclase in many bacterial species, including several multidrug-resistant human pathogens. The enzymatic product of CdaA, cyclic di-AMP, is a secondary messenger that is essential for the viability of many bacteria. Its absence in humans makes CdaA a very promising and attractive target for the development of new antibiotics. Here, the structural results are presented of a crystallographic fragment screen against CdaA from Listeria monocytogenes, a saprophytic Gram-positive bacterium and an opportunistic food-borne pathogen that can cause listeriosis in humans and animals. Two of the ...
Source: Acta Crystallographica Section D - April 29, 2024 Category: Biochemistry Authors: Neumann, P. Heidemann, J.L. Wollenhaupt, J. Dickmanns, A. Agthe, M. Weiss, M.S. Ficner, R. Tags: crystallographic fragment screening CdaA Listeria monocytogenes cyclic di-AMP drug design research papers Source Type: research

Biofilm-disrupting effects of phage endolysins LysAm24, LysAp22, LysECD7, and LysSi3: breakdown the matrix
AbstractThe ability of most opportunistic bacteria to form biofilms, coupled with antimicrobial resistance, hinder the efforts to control widespread infections, resulting in high risks of negative outcomes and economic costs. Endolysins are promising compounds that efficiently combat bacteria, including multidrug-resistant strains and biofilms, without a low probability of subsequent emergence of stable endolysin-resistant phenotypes. However, the details of antibiofilm effects of these enzymes are poorly understood. To elucidate the interactions of bacteriophage endolysins LysAm24, LysAp22, LysECD7, and LysSi3 with bacter...
Source: World Journal of Microbiology and Biotechnology - April 29, 2024 Category: Microbiology Source Type: research

Detection of metallo-beta-lactamase-producing genes bla SPM and bla NDM in Pseudomonas aeruginosa isolated from wastewater in Southern Brazil
The objective of this study was to investigate genes encoding metallo-beta-lactamases (MBLs), which confer resistance to carbapenems, in wastewater. Fifteen isolates of P. aeruginosa were collected for five months from samples obtained from a municipal wastewater treatment plant in Rio Grande do Sul. These isolates were subjected to disk diffusion testing using 10 different antimicrobials. Phenotypic enzymatic tests for MBLs were conducted, and positive isolates underwent DNA extraction and gene detection using the polymerase chain reaction. The resistance rate to ceftazidime was 100%, cefepime 73.3%, piperacillin-tazobact...
Source: Journal of Water and Health - April 28, 2024 Category: Environmental Health Authors: Vin ícius Monteagudo de Barros Bruna Seixas da Rocha Jaqueline Rhoden Jana ína Franciele Stein Simone Ulrich Picoli Caroline Rigotto Source Type: research