Development of an efficient liposomal DOX delivery formulation for HCC therapy by targeting CK2 α
Biotechnol J. 2024 Apr;19(4):e2400050. doi: 10.1002/biot.202400050.ABSTRACTHepatocellular carcinoma (HCC) is a digestive tract cancer with high mortality and poor prognosis, especially in China. Current chemotherapeutic drugs lead to poor prognosis, low efficacy, and high side effects due to weak targeting specificity and rapidly formed multidrug resistance (MDR). Based on the previous studies on the doxorubicin (DOX) formulation for cancer targeting therapy, we developed a novel DOX delivery formulation for the targeting chemotherapy of HCC and DOX resistant HCC. HCSP4 was previously screened and casein kinase 2α (CK2α)...
Source: Biotechnology Journal - April 23, 2024 Category: Biotechnology Authors: Ruixia Zhao Sinan Cheng Xue Bai Danying Zhang Hongming Fang Wanlin Che Wenxuan Zhang Yujuan Zhou Wei Duan Qiumin Liang Li Xiao Guochao Nie Yingchun Hou Source Type: research
Recurrent Chagas' disease meningomyelitis in an HIV-infected patient
We report a 59-year-old man native from the Northeast region of Brazil, with a second episode of subacute chagasic meningomyelitis. He had long-term multidrug-resistant HIV and had abandoned combined antiretroviral therapy (CD4+ lymphocyte count, 16 cells/mm³, and HIV viral load 169 403 copies/mL). He initially received benznidazole but switched to nifurtimox after developing myelotoxicity. He was discharged home having made a partial neurological improvement. Chagas' disease should be included in the differential diagnosis of meningomyelitis in people living with HIV/AIDS who are from endemic areas of this parasitic dise...
Source: Practical Neurology - April 23, 2024 Category: Neurology Authors: Igor Melo de Almeida Aline Borges Moreira da Rocha Jos é Angelo Lauletta Lindoso Vera L úcia Teixeira de Freitas Augusto Cp Oliveira Jose E Vidal Source Type: research
Development of an efficient liposomal DOX delivery formulation for HCC therapy by targeting CK2 α
Biotechnol J. 2024 Apr;19(4):e2400050. doi: 10.1002/biot.202400050.ABSTRACTHepatocellular carcinoma (HCC) is a digestive tract cancer with high mortality and poor prognosis, especially in China. Current chemotherapeutic drugs lead to poor prognosis, low efficacy, and high side effects due to weak targeting specificity and rapidly formed multidrug resistance (MDR). Based on the previous studies on the doxorubicin (DOX) formulation for cancer targeting therapy, we developed a novel DOX delivery formulation for the targeting chemotherapy of HCC and DOX resistant HCC. HCSP4 was previously screened and casein kinase 2α (CK2α)...
Source: Biotechnology Journal - April 23, 2024 Category: Biotechnology Authors: Ruixia Zhao Sinan Cheng Xue Bai Danying Zhang Hongming Fang Wanlin Che Wenxuan Zhang Yujuan Zhou Wei Duan Qiumin Liang Li Xiao Guochao Nie Yingchun Hou Source Type: research
Recurrent Chagas' disease meningomyelitis in an HIV-infected patient
We report a 59-year-old man native from the Northeast region of Brazil, with a second episode of subacute chagasic meningomyelitis. He had long-term multidrug-resistant HIV and had abandoned combined antiretroviral therapy (CD4+ lymphocyte count, 16 cells/mm³, and HIV viral load 169 403 copies/mL). He initially received benznidazole but switched to nifurtimox after developing myelotoxicity. He was discharged home having made a partial neurological improvement. Chagas' disease should be included in the differential diagnosis of meningomyelitis in people living with HIV/AIDS who are from endemic areas of this parasitic dise...
Source: Practical Neurology - April 23, 2024 Category: Neurology Authors: Igor Melo de Almeida Aline Borges Moreira da Rocha Jos é Angelo Lauletta Lindoso Vera L úcia Teixeira de Freitas Augusto Cp Oliveira Jose E Vidal Source Type: research
Development of an efficient liposomal DOX delivery formulation for HCC therapy by targeting CK2 α
Biotechnol J. 2024 Apr;19(4):e2400050. doi: 10.1002/biot.202400050.ABSTRACTHepatocellular carcinoma (HCC) is a digestive tract cancer with high mortality and poor prognosis, especially in China. Current chemotherapeutic drugs lead to poor prognosis, low efficacy, and high side effects due to weak targeting specificity and rapidly formed multidrug resistance (MDR). Based on the previous studies on the doxorubicin (DOX) formulation for cancer targeting therapy, we developed a novel DOX delivery formulation for the targeting chemotherapy of HCC and DOX resistant HCC. HCSP4 was previously screened and casein kinase 2α (CK2α)...
Source: Biotechnology Journal - April 23, 2024 Category: Biotechnology Authors: Ruixia Zhao Sinan Cheng Xue Bai Danying Zhang Hongming Fang Wanlin Che Wenxuan Zhang Yujuan Zhou Wei Duan Qiumin Liang Li Xiao Guochao Nie Yingchun Hou Source Type: research
Recurrent Chagas' disease meningomyelitis in an HIV-infected patient
We report a 59-year-old man native from the Northeast region of Brazil, with a second episode of subacute chagasic meningomyelitis. He had long-term multidrug-resistant HIV and had abandoned combined antiretroviral therapy (CD4+ lymphocyte count, 16 cells/mm³, and HIV viral load 169 403 copies/mL). He initially received benznidazole but switched to nifurtimox after developing myelotoxicity. He was discharged home having made a partial neurological improvement. Chagas' disease should be included in the differential diagnosis of meningomyelitis in people living with HIV/AIDS who are from endemic areas of this parasitic dise...
Source: Practical Neurology - April 23, 2024 Category: Neurology Authors: Igor Melo de Almeida Aline Borges Moreira da Rocha Jos é Angelo Lauletta Lindoso Vera L úcia Teixeira de Freitas Augusto Cp Oliveira Jose E Vidal Source Type: research
Development of an efficient liposomal DOX delivery formulation for HCC therapy by targeting CK2 α
Biotechnol J. 2024 Apr;19(4):e2400050. doi: 10.1002/biot.202400050.ABSTRACTHepatocellular carcinoma (HCC) is a digestive tract cancer with high mortality and poor prognosis, especially in China. Current chemotherapeutic drugs lead to poor prognosis, low efficacy, and high side effects due to weak targeting specificity and rapidly formed multidrug resistance (MDR). Based on the previous studies on the doxorubicin (DOX) formulation for cancer targeting therapy, we developed a novel DOX delivery formulation for the targeting chemotherapy of HCC and DOX resistant HCC. HCSP4 was previously screened and casein kinase 2α (CK2α)...
Source: Biotechnology Journal - April 23, 2024 Category: Biotechnology Authors: Ruixia Zhao Sinan Cheng Xue Bai Danying Zhang Hongming Fang Wanlin Che Wenxuan Zhang Yujuan Zhou Wei Duan Qiumin Liang Li Xiao Guochao Nie Yingchun Hou Source Type: research
Recurrent Chagas' disease meningomyelitis in an HIV-infected patient
We report a 59-year-old man native from the Northeast region of Brazil, with a second episode of subacute chagasic meningomyelitis. He had long-term multidrug-resistant HIV and had abandoned combined antiretroviral therapy (CD4+ lymphocyte count, 16 cells/mm³, and HIV viral load 169 403 copies/mL). He initially received benznidazole but switched to nifurtimox after developing myelotoxicity. He was discharged home having made a partial neurological improvement. Chagas' disease should be included in the differential diagnosis of meningomyelitis in people living with HIV/AIDS who are from endemic areas of this parasitic dise...
Source: Practical Neurology - April 23, 2024 Category: Neurology Authors: Igor Melo de Almeida Aline Borges Moreira da Rocha Jos é Angelo Lauletta Lindoso Vera L úcia Teixeira de Freitas Augusto Cp Oliveira Jose E Vidal Source Type: research
Molecules, Vol. 29, Pages 1906: Nature-Inspired Micro/Nano-Structured Antibacterial Surfaces
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He Li
The problem of bacterial resistance has become more and more common with improvements in health care. Worryingly, the misuse of antibiotics leads to an increase in bacterial multidrug resistance and the development of new antibiotics has virtually stalled. These challenges have prompted the need to combat bacterial infections with the use of radically different approaches. Taking lessons from the exciting properties of micro-/nano-natural-patterned surfaces, which can destroy cellular integrity, the construction of artificial surfaces to mimic natural functions provides new opportunities for the innovation an...
Source: Molecules - April 23, 2024 Category: Chemistry Authors: E Jin Zhijun Lv Yinghao Zhu Hongmei Zhang He Li Tags: Review Source Type: research
Lytic bacteriophages induce the secretion of antiviral and proinflammatory cytokines from human respiratory epithelial cells
by Paula F. Zamora, Thomas G. Reidy, Catherine R. Armbruster, Ming Sun, Daria Van Tyne, Paul E. Turner, Jonathan L. Koff, Jennifer M. Bomberger
Phage therapy is a therapeutic approach to treat multidrug-resistant (MDR) infections that employs lytic bacteriophages (phages) to eliminate bacteria. Despite the abundant evidence for its success as an antimicrobial in Eastern Europe, there is scarce data regarding its effects on the human host. Here, we aimed to understand how lytic phages interact with cells of the airway epithelium, the tissue site that is colonized by bacterial biofilms in numerous chronic respiratory disord...
Source: PLoS Biology: Archived Table of Contents - April 23, 2024 Category: Biology Authors: Paula F. Zamora Source Type: research
Pharmacokinetics and safety of EVER206, a novel polymyxin antimicrobial, in healthy Chinese subjects
This study was registered at the Chinese Clinical Trial Registry under identifier ChiCTR2200056692.PMID:38647294 | DOI:10.1128/aac.01563-23 (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - April 22, 2024 Category: Microbiology Authors: Size Li Xu Zhu Guoying Cao Jufang Shen Xu Zhu Jicheng Yu Xiaojie Wu Jufang Wu Haijing Yang Nanyang Li Yingying Hu Jingjing Wang Haihui Huang Jing Zhang Source Type: research
Biological Synthesis of Silver Nanoparticles from Lavandula mairei Humbert: Antibacterial and Antioxidant Activities
The objective of this study was to synthesize, for the first time, biologically silver nanoparticles (Ag-NPs) from Lavandula mairei Humbert (L. mairei) plant. The biosynthesized Ag-NPs were characterized by UV-visible spectral analysis, X-Ray diffraction Analysis, Fourier transform infrared spectroscopy analysis, scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy. Subsequently, the antibacterial and antioxidant activities of Ag-NPs were assessed using the micro-dilution method, DPPH test and FRAP assay, respectively. The green-synthesized Ag-NPs exhibited high antibacterial activity against ESBL-p...
Source: Current Microbiology - April 22, 2024 Category: Microbiology Authors: Soufiane El Megdar Lahbib Fayzi Raja Elkheloui Asma Laktib Mohamed Bourouache Abdellah El Boulani Hicham Abou Oualid Khalil Cherifi Fouad Msanda Mohamed Hassi Rachida Mimouni Fatima Hamadi Source Type: research
Mitigating antimicrobial resistance, an approach to stewardship in canine urinary tract infection
AbstractUrinary tract infection (UTI) caused by antimicrobial resistant bacteria is common in dogs leading to serious health impact in pet animal as well as on human health. Understanding the prevalent uropathogens and their drug susceptibility is essential for limiting the antimicrobial resistance through implementation of stewardship policies. In view of this, present study was envisaged to determine the prevalent bacterial uropathogens and their antibiogram from clinical cases of canine UTI. Urine samples were collected from 35 dogs presented with clinical signs of UTI and a total of 27 bacterial isolates were recovered...
Source: Veterinary Research Communications - April 22, 2024 Category: Veterinary Research Source Type: research
Unveilling genetic profiles and correlations of biofilm-associated genes, quorum sensing, and antibiotic resistance in Staphylococcus aureus isolated from a Malaysian Teaching Hospital
ConclusionsThe high prevalence of biofilm and slime production among MSSA and MRSA isolates correlates well with the detection of a high prevalence of biofilm-associated genes andagr quorum sensing system. A significant association ofagrI gene was found with cefoxitin, oxacillin, and fluoroquinolone resistance. A more focused approach targeting biofilm-associated and quorum sensing genes is important in developing new surveillance and treatment strategies againstS. aureus biofilm infection. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 22, 2024 Category: Research Source Type: research
Antimicrobial resistance and carbapenemase dissemination in < em > Pseudomonas aeruginosa < /em > isolates from Libyan hospitals: a call for surveillance and intervention
This study aimed to assess resistance of clinical isolates from Libyan hospitals to antipseudomonal antibiotics, the prevalence of selected extended-spectrum β-lactamases and carbapenemase genes among these isolates, and the microorganisms' capacity for alginate and biofilm production. Forty-five isolates were collected from four hospitals in Benghazi and Derna, Libya. Antimicrobial susceptibility was determined using agar disc diffusion. The presence of resistance genes (blaCTXM, blaTEM, blaSHV-1, blaGES-1, blaKPC, and blaNDM) was screened using PCR. Biofilm formation was quantified via the crystal violet assay, while al...
Source: Libyan Journal of Medicine - April 21, 2024 Category: General Medicine Authors: Nasrin K Gadaime Randa N Haddadin Asem A Shehabi Intisar N Omran Source Type: research
